ES398029A1 - Un procedimiento para la produccion de una sal farmaceuti- camente aceptable de una bis-cromona. - Google Patents

Un procedimiento para la produccion de una sal farmaceuti- camente aceptable de una bis-cromona.

Info

Publication number
ES398029A1
ES398029A1 ES398029A ES398029A ES398029A1 ES 398029 A1 ES398029 A1 ES 398029A1 ES 398029 A ES398029 A ES 398029A ES 398029 A ES398029 A ES 398029A ES 398029 A1 ES398029 A1 ES 398029A1
Authority
ES
Spain
Prior art keywords
substituted
alkoxy
compounds
alkyl
aminoalkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES398029A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Pharmaceuticals Ltd
Original Assignee
Fisons Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Pharmaceuticals Ltd filed Critical Fisons Pharmaceuticals Ltd
Publication of ES398029A1 publication Critical patent/ES398029A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES398029A 1968-10-30 1971-12-16 Un procedimiento para la produccion de una sal farmaceuti- camente aceptable de una bis-cromona. Expired ES398029A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51421/68A GB1292601A (en) 1968-10-30 1968-10-30 Bis-(2-carboxy-chromone) compounds, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES398029A1 true ES398029A1 (es) 1974-07-01

Family

ID=10459955

Family Applications (2)

Application Number Title Priority Date Filing Date
ES372916A Expired ES372916A1 (es) 1968-10-30 1969-10-27 Un procedimiento para preparar un compuesto de bis-cromona.
ES398029A Expired ES398029A1 (es) 1968-10-30 1971-12-16 Un procedimiento para la produccion de una sal farmaceuti- camente aceptable de una bis-cromona.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES372916A Expired ES372916A1 (es) 1968-10-30 1969-10-27 Un procedimiento para preparar un compuesto de bis-cromona.

Country Status (17)

Country Link
US (1) US3673218A (es)
AT (3) AT303037B (es)
BE (1) BE740548A (es)
BR (1) BR6913699D0 (es)
CA (1) CA948202A (es)
CH (2) CH527181A (es)
DE (1) DE1954266A1 (es)
DK (1) DK128005B (es)
ES (2) ES372916A1 (es)
FR (1) FR2021874B1 (es)
GB (1) GB1292601A (es)
IL (1) IL33189A (es)
IT (1) IT1035510B (es)
LU (1) LU59707A1 (es)
NL (1) NL6916387A (es)
OA (1) OA03859A (es)
SE (1) SE367403B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
GB1410588A (en) * 1971-08-10 1975-10-22 Fisons Ltd Composition
US3953604A (en) * 1972-01-14 1976-04-27 Miles Laboratories, Inc. 1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
SU469247A3 (ru) * 1972-01-14 1975-04-30 Майлз Лабораториз Инк (Фирма) Способ получени производных хромона
US4239748A (en) * 1977-11-30 1980-12-16 Fisons Limited Inorganic salts of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran useful for the treatment of asthma and hay fever
ZA786650B (en) * 1977-11-30 1980-07-30 Fisons Ltd Insoluble salts of benzodipyrans
US4447449A (en) * 1981-11-16 1984-05-08 The Upjohn Company Methods of treating ischemic states
US4584315A (en) * 1981-11-16 1986-04-22 The Upjohn Company Method of treating ischemic states
JP2868183B2 (ja) * 1988-02-29 1999-03-10 株式式社三和化学研究所 光学活性を有する４−オキソ−１−ベンゾピラン−２−カルボン酸誘導体の製法、その合成用中間体並びに該中間体の製法
EP0909258A1 (en) * 1996-06-21 1999-04-21 Syntroleum Corporation Synthesis gas production system and method
PE17599A1 (es) 1996-07-09 1999-02-22 Syntroleum Corp Procedimiento para convertir gases a liquidos
US5950732A (en) * 1997-04-02 1999-09-14 Syntroleum Corporation System and method for hydrate recovery
AU9690298A (en) 1997-10-10 1999-05-03 Syntroleum Corporation System and method for converting light hydrocarbons to heavier hydrocarbons withseparation of water into oxygen and hydrogen
US6794417B2 (en) 2002-06-19 2004-09-21 Syntroleum Corporation System and method for treatment of water and disposal of contaminants produced by converting lighter hydrocarbons into heavier hydrocarbon
US8754151B2 (en) 2010-12-21 2014-06-17 Basf Se Multistage polymer dispersions, processes for preparing them, and use thereof
TW201412727A (zh) * 2012-08-24 2014-04-01 Daiichi Sankyo Co Ltd 具有鏈狀側鏈之色酮衍生物
WO2014098597A1 (en) * 2012-12-21 2014-06-26 Rijksuniversiteit Groningen Novel bis-chromone derivatives, methods for their preparation and uses thereof
JP6266940B2 (ja) * 2013-10-07 2018-01-24 マナック株式会社 アリーレンジオキシ−ビス（無水コハク酸）及びその製造方法
WO2019054386A1 (ja) * 2017-09-12 2019-03-21 学校法人工学院大学 複素環化合物又はその塩、ｇｐｒ３５作動薬及び医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1144905A (en) * 1965-03-25 1969-03-12 Fisons Pharmaceuticals Ltd Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof
FR1489749A (fr) * 1965-03-25 1967-07-28 Fisons Pharmaceuticals Ltd Procédé de préparation de composés bis-chromonylés et leurs dérivés
GB1190194A (en) * 1966-07-05 1970-04-29 Fisons Pharmaceuticals Ltd Bis-Phenoxy Compounds and Chromanone and Chromone Derivatives

Also Published As

Publication number Publication date
ES372916A1 (es) 1972-03-01
AT303037B (de) 1972-11-10
IL33189A0 (en) 1969-12-31
FR2021874A1 (es) 1970-07-24
CH560210A5 (es) 1975-03-27
FR2021874B1 (es) 1974-08-09
NL6916387A (es) 1970-05-04
CH527181A (fr) 1972-08-31
LU59707A1 (es) 1970-05-04
SE367403B (es) 1974-05-27
IL33189A (en) 1974-01-14
US3673218A (en) 1972-06-27
AT301544B (de) 1972-09-11
DE1954266A1 (de) 1970-05-27
SU365068A3 (es) 1972-12-28
BE740548A (es) 1970-04-20
GB1292601A (en) 1972-10-11
AT302299B (de) 1972-10-10
IT1035510B (it) 1979-10-20
OA03859A (fr) 1971-12-24
CA948202A (en) 1974-05-28
BR6913699D0 (pt) 1973-02-13
DK128005B (da) 1974-02-18

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