ES387605A1 - Procedure for the obtaining of 17-alpha (lower rent) alenil-carbinols. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining 17α- (lower alkyl) alenyl-carbinoles of formula Iq: **(See formula)** wherein R1 represents an alkyl group containing 1 to 3 carbon atoms, R4 represents hydrogen, a hydroxy group or an alkanoyloxy group containing 2 to 4 carbon atoms, Z, encompassing rings A and B and the substituents on them. themselves represents **(See formula)** where R5 represents hydrogen, an alkyl group containing from 1 to 3 carbon atoms, a cycloalkyl group containing from 5 to 7 carbon atoms, or an alkanoyl group containing from 2 to 4 carbon atoms, R6 represents hydrogen, a 6α-methyl group or a 7α-methyl group, R7 represents hydrogen or a methyl group, and R8 represents hydrogen, halogen with an atomic weight of 19 to 36, or a methyl group and i) when rings A and B are represented by Z4, Z6, Z7 or Z8, where R6 represents hydrogen, R5 represents hydrogen or an alkanoyl group containing 2 to 4 carbon atoms, then R4 represents hydrogen, ii) when rings A and B are represented by Z1, in where R6 represents hydrogen, and R5 represents hydrogen, a methyl group or an alkanoyl group containing from 2 to 4 carbon atoms, R4 represents hydrogen, then R1 represents an alkyl group containing 1 or 2 carbon atoms, iii) when the Rings A and B are represented by Z1, then is R4 and R6 each represent hydrogen, characterized in that it comprises treating a corresponding compound containing an anion, of formula In: **(See formula)** where R1, R4 and Z are as defined above, with the additional restriction that Z is in protected form when necessary, with a methylating agent, preferably an excess methyl halide, and, when in the resulting product Z it is in protected form, thus unprotecting. (Machine-translation by Google Translate, not legally binding)