ES386652A1 - A procedure for preparation of 1,2,5-benzotriazepin carboxamides. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for preparation of 1,2,5-benzotriazepin carboxamides. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Sanofi Aventis France
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Roussel Uclaf SA
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Priority claimed from FR6945445Aexternal-prioritypatent/FR2029746B1/fr
Application filed by Roussel Uclaf SAfiledCriticalRoussel Uclaf SA
Publication of ES386652A1publicationCriticalpatent/ES386652A1/en
A process for the preparation of carboxamides of 1,2,5-benzotriazepines, of general formula I **(See formula)** as well as its quaternary ammonium salts, in which R represents a hydrogen atom, a halogen atom, a hydroxyl radical, a methoxy radical or a nitro group; R1 and R2, identical or different, represent an alcohol radical containing from 1 to 4 carbon atoms, R1 and R2 being able to form, together with the nitrogen atom that is attached to them, a nitrogenous heterocycle, capable of carrying another heteroelement; R3 represents a hydrogen atom or an alcohol radical containing from 1 to 4 carbon atoms; m and n represent, independently of each other, the values 0, 1, 2 or 3, and the sum of m and n cannot be less than 1, nor greater than 3, which is characterized by reacting, in the presence of an organic solvent, a 3 -carbalkoxy-1H-4,5-dihydro-l, 2,5-benzotriazepine, of general formula **(See formula)** wherein R has the same meaning as set out above, and R4 represents an alcohol radical containing 1 to 4 carbon atoms, with an alcohol ethylene diamine of general formula: **(See formula)** wherein R1, R2, R3, m and n have the same meaning as above, to obtain a carboxamide of general formula I: **(See formula)** in which R1, R2, R3, m and n retain the aforementioned meanings and values, which is transformed, if necessary, into a quaternary ammonium salt. (Machine-translation by Google Translate, not legally binding)
ES386652A1969-12-301970-12-19A procedure for preparation of 1,2,5-benzotriazepin carboxamides. (Machine-translation by Google Translate, not legally binding)
ExpiredES386652A1
(en)
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