ES381597A1 - ESTERS OF 3-HYDROXY- alpha -(1-AMINOETHYL)-BENZYL ALCOHOL - Google Patents

ESTERS OF 3-HYDROXY- alpha -(1-AMINOETHYL)-BENZYL ALCOHOL

Info

Publication number
ES381597A1
ES381597A1 ES381597A ES381597A ES381597A1 ES 381597 A1 ES381597 A1 ES 381597A1 ES 381597 A ES381597 A ES 381597A ES 381597 A ES381597 A ES 381597A ES 381597 A1 ES381597 A1 ES 381597A1
Authority
ES
Spain
Prior art keywords
aminoethyl
alpha
hydroxy
benzyl alcohol
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES381597A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES381597A1 publication Critical patent/ES381597A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel derivatives of 3-hydroxy- alpha -(1-aminoethyl)-benzyl alcohol, particularly ester derivatives of erythro or threo 3-hydroxy- alpha -(1-aminoethyl)-benzyl alcohol and the corresponding 3-ether and 3-ester derivatives thereof, are described. Processes for preparing such novel compounds are also described. The novel compounds are useful as antihypertensive agents and inhibitors of gastric secretion.
ES381597A 1969-07-10 1970-07-09 ESTERS OF 3-HYDROXY- alpha -(1-AMINOETHYL)-BENZYL ALCOHOL Expired ES381597A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84512069A 1969-07-10 1969-07-10

Publications (1)

Publication Number Publication Date
ES381597A1 true ES381597A1 (en) 1973-04-16

Family

ID=25294452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES381597A Expired ES381597A1 (en) 1969-07-10 1970-07-09 ESTERS OF 3-HYDROXY- alpha -(1-AMINOETHYL)-BENZYL ALCOHOL

Country Status (14)

Country Link
US (1) US3714229A (en)
JP (1) JPS5220463B1 (en)
AU (1) AU1710070A (en)
BE (1) BE753237A (en)
BR (1) BR6914798D0 (en)
CH (1) CH565138A5 (en)
DK (1) DK138418B (en)
ES (1) ES381597A1 (en)
FR (1) FR2059503B1 (en)
GB (1) GB1273653A (en)
IL (1) IL34831A0 (en)
NL (1) NL7009390A (en)
SE (1) SE383511B (en)
ZA (1) ZA704157B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4336400A (en) * 1969-04-01 1982-06-22 Sterling Drug Inc. 3-(Hydroxy or hydroxymethyl)-4-hydroxy-alpha(aminomethyl)benzyl alcohols and methods of use
US4138581A (en) * 1969-04-01 1979-02-06 Sterling Drugs Inc. 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols
GB1346401A (en) * 1971-05-12 1974-02-13 Lepetit Spa Cardioactive arylaminobutanols
US3928426A (en) * 1972-01-28 1975-12-23 Robins Co Inc A H 1-Cyclopropyl-1-phenyl-omega-amino-1-lower alkanoyloxyalkanes
US4001429A (en) * 1974-04-01 1977-01-04 A. H. Robins Company, Incorporated 1-Cyclopropyl-1-phenyl-ω-amino-1-alkanols and 1-lower-alkylacyl derivatives as analgetics
JPS556625B2 (en) * 1974-05-16 1980-02-18
JPS52171571U (en) * 1976-06-16 1977-12-27
JPS53114564U (en) * 1977-02-16 1978-09-12
DE2817494A1 (en) * 1977-05-03 1978-11-09 Continental Pharma AMINO ALCOHOL DERIVATIVE
JPS6210048A (en) * 1985-07-04 1987-01-19 Microbial Chem Res Found Novel physiologically active substance mh435
US5220063A (en) * 1991-05-10 1993-06-15 Hoechst Celanese Corporation Method for the preparation of arylalkanolacylamides
CN116332774A (en) * 2023-03-29 2023-06-27 成都瑞尔医药科技有限公司 Preparation method of high chiral purity meta-hydroxylamine bitartrate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2442797A (en) * 1943-10-05 1948-06-08 Sharp & Dohme Inc Para-amino benzoic acid esters
FR1537803A (en) * 1966-07-14 1968-08-30 Diwag Chemische Fabriken Gmbh Process for making acylaminophenolalkanols

Also Published As

Publication number Publication date
IL34831A0 (en) 1970-09-17
CH565138A5 (en) 1975-08-15
JPS5220463B1 (en) 1977-06-03
AU1710070A (en) 1972-01-06
FR2059503B1 (en) 1973-07-13
DK138418C (en) 1979-02-12
DE2034139A1 (en) 1971-02-04
US3714229A (en) 1973-01-30
DK138418B (en) 1978-09-04
BR6914798D0 (en) 1973-03-08
BE753237A (en) 1971-01-11
FR2059503A1 (en) 1971-06-04
SE383511B (en) 1976-03-15
NL7009390A (en) 1971-01-12
ZA704157B (en) 1972-01-26
GB1273653A (en) 1972-05-10

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