ES376066A3 - A procedure for the preparation of a benzymidazole 2- substituted. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of a benzymidazole 2- substituted. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Merck and Co Inc
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Merck and Co Inc
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Publication date
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Priority to ES376066ApriorityCriticalpatent/ES376066A3/en
Publication of ES376066A3publicationCriticalpatent/ES376066A3/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Plural Heterocyclic Compounds
(AREA)
Nitrogen Condensed Heterocyclic Rings
(AREA)
Abstract
A process for the preparation of a 2-substituted benzimidazole of formula Bz-r Where bz represents the benzimidazole nucleus and r is selected from the group consisting of aryl, heteroaryl, aralkyl and alkyl, which process consists in treating an amidine of formula ** (see formula) ** Wherein r is as defined above and p represents a monocyclic aryl radical, with a halogenating agent, in the absence of remarkable amounts of base, to form an N-halo-n'-phenyl (r-amidine) in which the halogen substituent is selected from the group consisting of chlorine and bromine and then contacting said N-haloamidine with an equimolar amount of at least base. (Machine-translation by Google Translate, not legally binding)
ES376066A1970-01-301970-01-30A procedure for the preparation of a benzymidazole 2- substituted. (Machine-translation by Google Translate, not legally binding)
ExpiredES376066A3
(en)
Procedure for the obtaining of new derivatives of heterocyclic hydrazines and their salts (Machine-translation by Google Translate, not legally binding)