ES375520A1 - Epoxyethylphosphonic acid derivatives - Google Patents

Epoxyethylphosphonic acid derivatives

Info

Publication number
ES375520A1
ES375520A1 ES375520A ES375520A ES375520A1 ES 375520 A1 ES375520 A1 ES 375520A1 ES 375520 A ES375520 A ES 375520A ES 375520 A ES375520 A ES 375520A ES 375520 A1 ES375520 A1 ES 375520A1
Authority
ES
Spain
Prior art keywords
see formula
derivatives
distereoisomeric
distereoisomer
epoxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES375520A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES375520A1 publication Critical patent/ES375520A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6587—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having two phosphorus atoms as ring hetero atoms in the same ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

A method of obtaining enantiomers of (1-R6-epoxyethyl) phosphonic acid or one of its derivatives, characterized in that it consists of separating a distereoisomeric salt from a mixture of distereoisomeric salts of (1-R6-epoxyethyl) phosphoric acid or of one of its derivatives, recovering the distereoisomer of the antibacterially active enantiomer and converting said distereoisomer into an enantiomeric derivative of the formula **(See formula)** where R6 represents hydrogen or lower alkyl; X represents oxygen or sulfur; Y and Z each represent the same or different radicals selected from -OR, -SR, -NR1R2, (see formula), -NR-OR, -NR-NR1R2, -NR-N = CR1R2, (see formula), -N = C = X, (see formula), N3 or halogen. (Machine-translation by Google Translate, not legally binding)
ES375520A 1969-01-21 1970-01-16 Epoxyethylphosphonic acid derivatives Expired ES375520A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79392569A 1969-01-21 1969-01-21

Publications (1)

Publication Number Publication Date
ES375520A1 true ES375520A1 (en) 1972-05-16

Family

ID=25161171

Family Applications (1)

Application Number Title Priority Date Filing Date
ES375520A Expired ES375520A1 (en) 1969-01-21 1970-01-16 Epoxyethylphosphonic acid derivatives

Country Status (14)

Country Link
AT (1) AT306742B (en)
BE (1) BE744653A (en)
BR (1) BR6914880D0 (en)
CA (1) CA985692A (en)
CH (1) CH542162A (en)
DE (1) DE2002415A1 (en)
ES (1) ES375520A1 (en)
FR (1) FR2034476B1 (en)
GB (1) GB1282672A (en)
HU (1) HU164087B (en)
IE (1) IE33941B1 (en)
IL (1) IL33686A0 (en)
NL (1) NL7000224A (en)
ZA (1) ZA698597B (en)

Also Published As

Publication number Publication date
BE744653A (en) 1970-07-20
IL33686A0 (en) 1970-03-22
IE33941L (en) 1970-07-21
FR2034476A1 (en) 1970-12-11
FR2034476B1 (en) 1973-08-10
HU164087B (en) 1973-12-28
CA985692A (en) 1976-03-16
BR6914880D0 (en) 1973-04-19
IE33941B1 (en) 1974-12-11
AT306742B (en) 1973-04-25
CH542162A (en) 1973-09-30
GB1282672A (en) 1972-07-19
NL7000224A (en) 1970-07-23
ZA698597B (en) 1971-07-28
DE2002415A1 (en) 1970-11-26

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