ES374371A2 - A procedure for the preparation of new substitute indoles. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of new substitute indoles. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES374371A2
ES374371A2 ES374371A ES374371A ES374371A2 ES 374371 A2 ES374371 A2 ES 374371A2 ES 374371 A ES374371 A ES 374371A ES 374371 A ES374371 A ES 374371A ES 374371 A2 ES374371 A2 ES 374371A2
Authority
ES
Spain
Prior art keywords
chloroindole
alpha
methyl
translation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES374371A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES374371A2 publication Critical patent/ES374371A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)

Abstract

Improvements introduced in the object of the main patent nº 371,374, requested on 10.9.69, by: "a process for the preparation of new substituted indoles", in particular racemic or optically active 1- (alpha-carboxyethyl) 2-methyl-3-para-chlorobenzoyl-6-chloroindole, and its esters or salts, characterized by reacting an alkaline agent with 2-methyl-3-parachlorobenzoyl-6-chloroindole to form an alkaline derivative of the latter, said alkaline derivative is condensed with a lower alkyl ester of the alpha-halogenated propionic acid, in which the term halogen represents an atom of chlorine, bromine or iodine, to obtain a lower alkyl ester of 1- (alpha-carboxyethyl) 2-methyl-3-parachlorobenzoyl 6-chloroindole, which is saponified to obtain 1- (alpha-carboxyethyl) 2-methyl 3-para-chlorobenzoyl 6-chloroindole which, if appropriate, is subjected to an esterification or salification agent, or is cleaved by means of an optically active base in its optical antipodes. (Machine-translation by Google Translate, not legally binding)
ES374371A 1968-12-10 1969-12-09 A procedure for the preparation of new substitute indoles. (Machine-translation by Google Translate, not legally binding) Expired ES374371A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR75177431A FR8439M (en) 1968-12-10 1968-12-10

Publications (1)

Publication Number Publication Date
ES374371A2 true ES374371A2 (en) 1972-01-01

Family

ID=8658089

Family Applications (1)

Application Number Title Priority Date Filing Date
ES374371A Expired ES374371A2 (en) 1968-12-10 1969-12-09 A procedure for the preparation of new substitute indoles. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES374371A2 (en)
FR (1) FR8439M (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2554819B1 (en) * 1983-11-10 1986-05-16 Adir NOVEL THIENO (2,3-B) PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2564467B1 (en) * 1984-05-21 1987-08-21 Adir NOVEL THIENO (2,3-B) PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2565981B1 (en) * 1984-06-15 1986-09-19 Adir NOVEL THIENO (2,3-B) PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
FR8439M (en) 1971-07-15

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