ES374323A1 - Aminopropiophenones with analgetic and sedative - properties - Google Patents

Aminopropiophenones with analgetic and sedative - properties

Info

Publication number
ES374323A1
ES374323A1 ES374323A ES374323A ES374323A1 ES 374323 A1 ES374323 A1 ES 374323A1 ES 374323 A ES374323 A ES 374323A ES 374323 A ES374323 A ES 374323A ES 374323 A1 ES374323 A1 ES 374323A1
Authority
ES
Spain
Prior art keywords
beta
aminopropiophenones
analgetic
sedative
properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES374323A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK120969A external-priority patent/DK125242B/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES374323A1 publication Critical patent/ES374323A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

New aminopropiophenones of formula:- (where R and R' are alkyls with 3 or 4C, or R = H), esp. the beta-butyl-amino or beta-propylamino-propiohenones, are prepared from the corresponding beta-halogeno derivs. and amines RR'NH or the 4-acylamino cpds. are hydrolysed or the related secondary alcohols are oxidised or appropriately substituted acetophenones are condensed with HCHO and bases RR'NH in the presence of an acid or the amine salt. The products have better analgetic and sedative properties than previous cpds. of this type.
ES374323A 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties Expired ES374323A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK120969A DK125242B (en) 1968-03-06 1969-03-04 Analogous process for the preparation of amino ketones.

Publications (1)

Publication Number Publication Date
ES374323A1 true ES374323A1 (en) 1971-12-16

Family

ID=8102199

Family Applications (5)

Application Number Title Priority Date Filing Date
ES374151A Expired ES374151A1 (en) 1969-03-04 1969-12-02 Aminopropiophenones with analgetic and sedative - properties
ES374322A Expired ES374322A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374324A Expired ES374324A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374323A Expired ES374323A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374321A Expired ES374321A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES374151A Expired ES374151A1 (en) 1969-03-04 1969-12-02 Aminopropiophenones with analgetic and sedative - properties
ES374322A Expired ES374322A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties
ES374324A Expired ES374324A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES374321A Expired ES374321A1 (en) 1969-03-04 1969-12-06 Aminopropiophenones with analgetic and sedative - properties

Country Status (9)

Country Link
JP (1) JPS4817266B1 (en)
BG (4) BG17534A3 (en)
DE (1) DE1943777A1 (en)
ES (5) ES374151A1 (en)
HU (1) HU162685B (en)
IL (1) IL33993A (en)
NO (1) NO126617B (en)
RO (1) RO55610A (en)
SU (1) SU364160A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041087A1 (en) * 1980-06-03 1981-12-09 Saunders Transport Limited Wheel cleaner with powered rollers
US4906781A (en) * 1983-02-01 1990-03-06 American Cyanamid Company Method for the preparation of 4'-(substituted)-amino-2-(substituted) amino-3',5'-dichloroacetophenone and salts thereof
FR2626878B1 (en) * 1988-02-10 1990-06-08 Lafon Labor 1- (AMINOPHENYL) -2-DIMETHYLAMINOPROPANONE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE

Also Published As

Publication number Publication date
JPS4817266B1 (en) 1973-05-28
IL33993A0 (en) 1970-05-21
BG18180A3 (en) 1974-09-02
BG17534A3 (en) 1973-11-10
ES374322A1 (en) 1971-12-16
ES374321A1 (en) 1971-12-16
IL33993A (en) 1973-08-29
BG17533A3 (en) 1973-11-10
BG17532A3 (en) 1973-11-10
SU364160A3 (en) 1972-12-25
ES374324A1 (en) 1971-12-16
RO55610A (en) 1973-09-20
HU162685B (en) 1973-03-28
ES374151A1 (en) 1971-12-16
DE1943777A1 (en) 1970-09-24
NO126617B (en) 1973-03-05

Similar Documents

Publication Publication Date Title
GB1525110A (en) Paper manufacture with retention agents
CH534165A (en) Process for the preparation of 2,3,5-trisubstituted-2'-hydroxy-6,7-benzomorphans
ES412387A1 (en) Formulation for oral administration of penicillins having improved taste properties
CH550821A (en) PROCESS FOR THE PREPARATION OF 1,2,3,11B-TETRAHYDROPYRIDO (3,4,5: M, N) THIOXANTHENES AND THEIR ACID ADDITION SALTS.
ES374324A1 (en) Aminopropiophenones with analgetic and sedative - properties
GB1280694A (en) Unsaturated polyamides
CH551506A (en) METHOD OF MANUFACTURING TEXTURED MOLECULAR ORIENTED FEDES.
GB1185618A (en) A Process for the Manufacture of Isoindole Derivatives
CH526608A (en) Process for the production of coatings or moldings which contain polycondensates or mixed polycondensates containing imide groups.
CH555837A (en) PROCESS FOR THE PREPARATION OF SUBSTITUTED 1,2-DIHYDRO1,3,5-TRIAZINES.
CH549581A (en) PROCESS FOR THE PREPARATION OF 4-AMINO-6,7,8-TRIALCOXYCHINAZOLINES.
FR2036989A1 (en) Amidino hydrazone antivirals
AT292700B (en) Process for the preparation of new 1,1'-disubstituted 1,1'-dihydro-4,4'-bipyridyls or 1,1'-disubstituted 1,1'-dihydro-2,2'-bipyridyls
CH534157A (en) Process for the preparation of N-substituted 2,6-diaminopyridines
ES410122A1 (en) Certain 3-amino-prop-1-enes for treating Trypanosoma cruzi infections
BE764558A (en) N, N'-BIS-TRIFLUOROMETHYL-TETRAFLUORETHYLENE DIAMINE
GB1299801A (en) Process for preparing benzodiazepine derivatives and salts thereof
AT321920B (en) PROCESS FOR THE PREPARATION OF NEW 3,6-BIS- (AMINOACYLAMINO) -ACRIDINES AND THEIR ACID-ADDITIONAL SALTS
AT273148B (en) Process for the preparation of new water-soluble or water-dispersible, condensable melamine derivatives
GB1374475A (en) Benzodiazepine derivatives
CH547249A (en) PROCESS FOR THE PREPARATION OF MONOETHERS OF 1,2-DIHYDROXYBENZENE.
AT281839B (en) Process for the preparation of new 2-methyl-3-amidino-quinoxaline-di-N-oxides (1,4) substituted on the amidine nitrogen
FR2215217A1 (en) Ortho thymotic acid di alkyl amines - coronary dilators, anti arrhythmic agents, local anaesthetics and antitussives
CH548372A (en) Process for the preparation of N, N, N'-SUBSTITUTED UREA.
FR2081556A1 (en) N-acyldiarylamidines - useful as diuretics analgesics and hypertensives