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Daiichi Pharmaceutical Co Ltd
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Daiichi Pharmaceutical Co Ltd
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Application filed by Daiichi Pharmaceutical Co LtdfiledCriticalDaiichi Pharmaceutical Co Ltd
Priority to ES367574ApriorityCriticalpatent/ES367574A1/en
Publication of ES367574A1publicationCriticalpatent/ES367574A1/en
Preparation method of pyrazine derivatives, and more particularly for the preparation of the compound of the formula: **(See formula)** wherein X is selected from the group consisting of alkoxy, piperidino, morpholino and oxazolidino and Y is selected from the group consisting of hydrogen and alkoxy, said alkoxy group containing from 1 to 5 carbon atoms, characterized in that it comprises reacting a derivative of pyrazine-2-carboxylic acid represented by the formula: **(See formula)** wherein Y has the same value as defined above, with alkyl alcohol containing 1 to 5 carbon atoms in the presence of a catalyst chosen from the group consisting of mineral acids and thionyl chloride to produce the ester represented by the following formula : **(See formula)** wherein Y has the same value as defined above and R represents a C1-C5 alkyl radical, and then reacting the ester with an amine chosen from the group consisting of piperidine, morpholine and oxazolidine. (Machine-translation by Google Translate, not legally binding)
ES367574A1969-05-091969-05-09Method of preparation of piracine derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES367574A1
(en)