ES367376A1 - Un procedimiento para la preparacion de derivados de benzo-diacepina. - Google Patents
Un procedimiento para la preparacion de derivados de benzo-diacepina.Info
- Publication number
- ES367376A1 ES367376A1 ES367376A ES367376A ES367376A1 ES 367376 A1 ES367376 A1 ES 367376A1 ES 367376 A ES367376 A ES 367376A ES 367376 A ES367376 A ES 367376A ES 367376 A1 ES367376 A1 ES 367376A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- methylide
- general formula
- benzodiazepines
- methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 230000011987 methylation Effects 0.000 title 1
- 238000007069 methylation reaction Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- GZRYBYIBLHMWCD-UHFFFAOYSA-N dimethyl(methylidene)-$l^{4}-sulfane Chemical compound CS(C)=C GZRYBYIBLHMWCD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- LGRLWUINFJPLSH-UHFFFAOYSA-N methanide Chemical compound [CH3-] LGRLWUINFJPLSH-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- GRKWHXNAHIMNJD-UHFFFAOYSA-N methoxysulfanyloxymethane Chemical compound COSOC GRKWHXNAHIMNJD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73063868A | 1968-05-20 | 1968-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES367376A1 true ES367376A1 (es) | 1971-04-16 |
Family
ID=24936167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES367376A Expired ES367376A1 (es) | 1968-05-20 | 1969-05-19 | Un procedimiento para la preparacion de derivados de benzo-diacepina. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3534021A (es) |
| AT (1) | AT285616B (es) |
| BR (1) | BR6908925D0 (es) |
| CH (1) | CH510034A (es) |
| ES (1) | ES367376A1 (es) |
| FI (1) | FI50123C (es) |
| NO (1) | NO122248B (es) |
| SE (1) | SE365516B (es) |
| YU (1) | YU34202B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1433103A (en) * | 1974-03-20 | 1976-04-22 | Lepetit Spa | Pharmacologically active pyrrolodiazepines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3371085A (en) * | 1959-12-10 | 1968-02-27 | Hoffmann La Roche | 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones |
-
1968
- 1968-05-20 US US730638A patent/US3534021A/en not_active Expired - Lifetime
-
1969
- 1969-04-25 CH CH631669A patent/CH510034A/de not_active IP Right Cessation
- 1969-05-19 AT AT473669A patent/AT285616B/de not_active IP Right Cessation
- 1969-05-19 ES ES367376A patent/ES367376A1/es not_active Expired
- 1969-05-19 BR BR208925/69A patent/BR6908925D0/pt unknown
- 1969-05-19 YU YU1240/69A patent/YU34202B/xx unknown
- 1969-05-19 NO NO2033/69A patent/NO122248B/no unknown
- 1969-05-20 FI FI691517A patent/FI50123C/fi active
- 1969-05-20 SE SE07109/69A patent/SE365516B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE365516B (es) | 1974-03-25 |
| AT285616B (de) | 1970-11-10 |
| YU34202B (en) | 1979-02-28 |
| US3534021A (en) | 1970-10-13 |
| FI50123C (fi) | 1975-12-10 |
| BR6908925D0 (pt) | 1973-01-09 |
| CH510034A (de) | 1971-07-15 |
| YU124069A (en) | 1978-06-30 |
| FI50123B (es) | 1975-09-01 |
| NO122248B (es) | 1971-06-07 |
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