ES364636A1 - Procedure for the preparation of new derivatives of 5h-dibenz (b, f) azepine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new 5h-dibenz [b, f] azepine derivatives of the general formula i ** (see formula) ** In which R1 means hydrogen or a lower alkyl group with at most 3 carbon atoms, R2 means hydrogen or a lower alkyl group with at most 4 carbon atoms, R3 signifies hydrogen or chlorine, as well as the salts of the carboxylic acids falling under the general formula i, characterized in that a compound of the general formula ii ** (see formula) ** In which R1 means an alkyl group with at most 3 carbon atoms; A1 means a lower alkoxycarbonyl group (-co-o-alkyl) or the cyano group and a2 means a lower alkoxycarbonyl group, a lower alkoxyalkyl group (-co-co-o-alkyl), the cyano group or the acetyl group and r2 and r3 have the significance indicated under formula i, It is allowed to react in an organic or aqueous-organic medium with an alkaline hydroxide or, if neither a, nor a2 is a cyano group, in water-free medium also with an alkaline alkanolate or, in case a2 is not a acetyl radical, in organic-aqueous medium also with a mineral acid, of the alkali salt of a dicarboxylic acid optionally obtained first in the use of an alkaline hydroxide the acid is released and heated until splitting of the equimolar dose of carbon dioxide and eventually carbon monoxide, and if desired a free monocarboxylic acid obtained is transformed into a salt with an inorganic or organic base or a salt obtained from a monocarboxylic acid of the general formula i the latter is released. (Machine-translation by Google Translate, not legally binding)