ES359536A1 - Antibacterial epoxypropylphosphonic acid and esters - as an antibiotic - Google Patents

Antibacterial epoxypropylphosphonic acid and esters - as an antibiotic

Info

Publication number
ES359536A1
ES359536A1 ES359536A ES359536A ES359536A1 ES 359536 A1 ES359536 A1 ES 359536A1 ES 359536 A ES359536 A ES 359536A ES 359536 A ES359536 A ES 359536A ES 359536 A1 ES359536 A1 ES 359536A1
Authority
ES
Spain
Prior art keywords
esters
antibiotic
antibacterial
epoxypropylphosphonic acid
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES359536A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES359536A1 publication Critical patent/ES359536A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826Acyclic unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505Phosphonic acids containing oxirane groups; esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(+-) (Trans-1,2-epoxypropyl)phosphonic acid and esters (I) and salts R = h or hydrocarbyl, e.g. lower alkyl/alkenyl/alkynyl, cycloalkyl, aralkyl, aryl, heteroaryl. - Active against Bacillus, Escherichia, Staphylococcus, Salmonella and Proteus spp. including antibiotic-resistant strains.
ES359536A 1968-05-15 1968-10-25 Antibacterial epoxypropylphosphonic acid and esters - as an antibiotic Expired ES359536A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72942168A 1968-05-15 1968-05-15

Publications (1)

Publication Number Publication Date
ES359536A1 true ES359536A1 (en) 1970-08-16

Family

ID=24930945

Family Applications (1)

Application Number Title Priority Date Filing Date
ES359536A Expired ES359536A1 (en) 1968-05-15 1968-10-25 Antibacterial epoxypropylphosphonic acid and esters - as an antibiotic

Country Status (8)

Country Link
BE (1) BE723077A (en)
DE (1) DE1805685A1 (en)
ES (1) ES359536A1 (en)
IL (1) IL30916A0 (en)
LU (1) LU57185A1 (en)
MT (1) MTP585B (en)
NL (1) NL6814976A (en)
ZM (1) ZM13668A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2522081A1 (en) * 1975-05-17 1976-11-25 Boehringer Mannheim Gmbh ANTIBIOTICALLY EFFECTIVE PREPARATION
CN113522269B (en) * 2021-08-20 2023-05-02 四川大学华西医院 Based on Zn 2 V 2 O 7 Nanocrystalline biocatalysts and their use in the preparation of enzyme-like preparations and antibacterial agents
CN117964661A (en) * 2024-04-01 2024-05-03 深圳创元生物医药科技有限公司 Preparation method of fosfomycin genotoxic impurity C

Also Published As

Publication number Publication date
BE723077A (en) 1969-04-29
MTP585B (en) 1970-05-18
IL30916A0 (en) 1968-12-26
NL6814976A (en) 1969-11-18
DE1805685A1 (en) 1970-05-27
ZM13668A1 (en) 1970-06-18
LU57185A1 (en) 1969-05-16

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