ES352202A1 - Procedimiento para la preparacion de derivados de tebaina yoripavina. - Google Patents
Procedimiento para la preparacion de derivados de tebaina yoripavina.Info
- Publication number
- ES352202A1 ES352202A1 ES352202A ES352202A ES352202A1 ES 352202 A1 ES352202 A1 ES 352202A1 ES 352202 A ES352202 A ES 352202A ES 352202 A ES352202 A ES 352202A ES 352202 A1 ES352202 A1 ES 352202A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- alkyl
- methyl
- bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 239000002585 base Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 methylallyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000003944 tolyl group Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 125000005394 methallyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002900 organolithium compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB04948/67A GB1164672A (en) | 1967-03-31 | 1967-03-31 | Novel Derivatives of Thebaine and Oripavine, their Pharmaceutically Acceptable Salts, and to processes of their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES352202A1 true ES352202A1 (es) | 1969-07-01 |
Family
ID=10050373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES352202A Expired ES352202A1 (es) | 1967-03-31 | 1968-03-30 | Procedimiento para la preparacion de derivados de tebaina yoripavina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3464993A (forum.php) |
| AT (1) | AT281305B (forum.php) |
| BE (1) | BE712960A (forum.php) |
| DE (1) | DE1770106A1 (forum.php) |
| DK (1) | DK119012B (forum.php) |
| ES (1) | ES352202A1 (forum.php) |
| FR (2) | FR8376M (forum.php) |
| GB (1) | GB1164672A (forum.php) |
| LU (1) | LU55799A1 (forum.php) |
| NL (1) | NL6804426A (forum.php) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421026A1 (fr) * | 1978-03-28 | 1979-10-26 | Glaenzer Spicer Sa | Dispositif de support de pieces destinees a subir une operation de brochage ou analogue |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3285914A (en) * | 1964-06-11 | 1966-11-15 | Smith Kline French Lab | 3-n-substituted derivatives of oripavine and thebaine |
| GB1116595A (en) * | 1964-07-08 | 1968-06-06 | Reckitt & Sons Ltd | Codeine and morphine derivatives |
| GB1146272A (en) * | 1966-01-17 | 1969-03-26 | Reckitt & Sons Ltd | Novel thebaine and oripavine derivatives |
-
1967
- 1967-03-31 GB GB04948/67A patent/GB1164672A/en not_active Expired
-
1968
- 1968-03-25 US US715498A patent/US3464993A/en not_active Expired - Lifetime
- 1968-03-29 LU LU55799D patent/LU55799A1/xx unknown
- 1968-03-29 BE BE712960D patent/BE712960A/xx unknown
- 1968-03-29 DK DK137968AA patent/DK119012B/da unknown
- 1968-03-29 FR FR146442A patent/FR8376M/fr not_active Expired
- 1968-03-29 AT AT311168A patent/AT281305B/de not_active IP Right Cessation
- 1968-03-29 FR FR1583792D patent/FR1583792A/fr not_active Expired
- 1968-03-29 NL NL6804426A patent/NL6804426A/xx unknown
- 1968-03-30 ES ES352202A patent/ES352202A1/es not_active Expired
- 1968-04-01 DE DE19681770106 patent/DE1770106A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| LU55799A1 (forum.php) | 1968-07-30 |
| AT281305B (de) | 1970-05-11 |
| BE712960A (forum.php) | 1968-07-31 |
| DE1770106A1 (de) | 1971-09-23 |
| NL6804426A (forum.php) | 1968-10-01 |
| US3464993A (en) | 1969-09-02 |
| FR1583792A (forum.php) | 1969-12-05 |
| DK119012B (da) | 1970-11-02 |
| FR8376M (forum.php) | 1971-02-22 |
| GB1164672A (en) | 1969-09-17 |
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