ES312499A1 - Procedure for the obtaining of diazacicloalcanos. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining (See formula) -N'-Z-diazacycloalkanes, in which the nitrogen atoms of the diazacycloalkane are separated from each other, by at least 2 carbon atoms, and where Pyr- (4) represents a pyrazolyl radical (4), X is oxygen or a hydrogen atom together with free or substituted hydroxy radical, Z an aromatic moiety and Alk a lower alkylidene- (1,1) moiety, characterized in that a 4-lower alkanoyl-pyrazole is reacted with formaldehyde and an N-unsubstituted N'-Z-diazacycloalkane, whose nitrogen atoms are each time separated from each other by at least 2 carbon atoms, or an amine compound, containing at least one atom in the nitrogen atom of hydrogen, and which allows the synthesis of a N'-Z-diazacycloalkanic ring, or a (see formula) -pyrazole, where Y is an esterified hydroxyl radical, capable of reaction, is reacted with the aforementioned N'-Z-diazacycloalkane or the amine compound and, in the compounds obtained with the mentioned radical, which allows the synthesis of a N'-Z-diazacycloalkanic ring, the synthesis of the N'-Z-diazacycloalkanic ring is made and, at any stage of the process, if desired, the oxo radical is reduced to the hydroxy radical and, if desired, this is it replaces and/or the nitro radicals existing in the obtained compounds are reduced to amine radicals and/or the free bases obtained are transformed into their salts or the salts obtained in the free bases and/or, if desired, the obtained racemates are dissociated to the optical antipodes. (Machine-translation by Google Translate, not legally binding)