ES2978413T3 - Condiciones determinantes para la purificación de proteínas - Google Patents
Condiciones determinantes para la purificación de proteínas Download PDFInfo
- Publication number
- ES2978413T3 ES2978413T3 ES19710843T ES19710843T ES2978413T3 ES 2978413 T3 ES2978413 T3 ES 2978413T3 ES 19710843 T ES19710843 T ES 19710843T ES 19710843 T ES19710843 T ES 19710843T ES 2978413 T3 ES2978413 T3 ES 2978413T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- proteins
- stationary phase
- data
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8658—Optimising operation parameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8693—Models, e.g. prediction of retention times, method development and validation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/20—Probabilistic models
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/889—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 monitoring the quality of the stationary phase; column performance
Landscapes
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Probability & Statistics with Applications (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862633584P | 2018-02-21 | 2018-02-21 | |
| PCT/US2019/019050 WO2019165148A1 (en) | 2018-02-21 | 2019-02-21 | Determining conditions for purification of proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2978413T3 true ES2978413T3 (es) | 2024-09-12 |
Family
ID=65763767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19710843T Active ES2978413T3 (es) | 2018-02-21 | 2019-02-21 | Condiciones determinantes para la purificación de proteínas |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200408728A1 (https=) |
| EP (2) | EP3755447B1 (https=) |
| JP (1) | JP7332610B2 (https=) |
| CA (1) | CA3091905C (https=) |
| ES (1) | ES2978413T3 (https=) |
| WO (1) | WO2019165148A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| MX2022013313A (es) * | 2020-04-23 | 2022-11-30 | Amgen Inc | Seleccion de parametros de cromatografia para la fabricacion de proteinas terapeuticas. |
| CA3195893A1 (en) * | 2020-09-21 | 2022-03-24 | Bayer Healthcare Llc | Pathogen clearance system and method |
| WO2025064403A2 (en) * | 2023-09-18 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| CN121075496B (zh) * | 2025-11-05 | 2026-03-27 | 鲁东大学 | 一种基于特征工程与集成学习的蛋白质盐敏感性预测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020010566A1 (en) * | 2000-04-11 | 2002-01-24 | Chester Thomas Lee | Methods for modeling, predicting, and optimizing high performance liquid chromatography parameters |
| US20040034477A1 (en) * | 2002-08-19 | 2004-02-19 | Mcbrien Michael | Methods for modeling chromatographic variables |
| EP1539321A1 (de) * | 2002-09-19 | 2005-06-15 | MERCK PATENT GmbH | Verfahren zum auffinden geeigneter chromatographiebedingungen zur trennung biologischer moleküle |
| DE102006027496B3 (de) * | 2006-06-14 | 2008-01-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Optimierung chromatographischer Reinigungsverfahren für Biomoleküle |
| US11460455B2 (en) * | 2014-11-12 | 2022-10-04 | Cytiva Sweden Ab | Method and system for determining the influence of experimental parameters on a liquid chromatography protocol |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
-
2019
- 2019-02-21 JP JP2020544212A patent/JP7332610B2/ja active Active
- 2019-02-21 ES ES19710843T patent/ES2978413T3/es active Active
- 2019-02-21 EP EP19710843.4A patent/EP3755447B1/en active Active
- 2019-02-21 WO PCT/US2019/019050 patent/WO2019165148A1/en not_active Ceased
- 2019-02-21 EP EP24161128.4A patent/EP4372376B1/en active Active
- 2019-02-21 US US16/969,522 patent/US20200408728A1/en active Pending
- 2019-02-21 CA CA3091905A patent/CA3091905C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019165148A1 (en) | 2019-08-29 |
| JP7332610B2 (ja) | 2023-08-23 |
| EP4372376A3 (en) | 2024-07-17 |
| CA3091905A1 (en) | 2019-08-29 |
| EP3755447B1 (en) | 2024-03-06 |
| EP4372376B1 (en) | 2026-04-01 |
| EP4372376A2 (en) | 2024-05-22 |
| EP3755447A1 (en) | 2020-12-30 |
| US20200408728A1 (en) | 2020-12-31 |
| CA3091905C (en) | 2023-03-21 |
| JP2021521412A (ja) | 2021-08-26 |
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