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Merck and Co Inc
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Merck and Co Inc
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Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Priority to ES0295106ApriorityCriticalpatent/ES295106A1/en
Publication of ES295106A1publicationCriticalpatent/ES295106A1/en
Process for the preparation of dibenzo [b, c] tiepine, and especially compounds of structural formula ** (See formula) ** where R is a levyalkyl radical, and X, X 'are each selected from the group consisting of hydrogen, halogens, levyalkyl, perfluorolevialkyl, levialkoxyl, levialkylmercapto, levyalkylsulfonyl, sulfamoyl, levyalkylsulphamoyl, dilevialkylsufamoyl or acyl, which comprises the following steps: 1) Reaction of a compound of formula ** (See formula) ** where X, X 'are as defined, with a Grignard reagent of formula HalMgCH2CH2CH2N (R) 2, where Hal denotes a halogen and R is as defined, in the presence of an inert organic solvent. 2) Hydrolysis of the Grignard derivative resulting from step 1), to form the corresponding 11-hydroxy-11- (3-tertiaryminopropyl) derivative. 3) Reduction of the derivative obtained in step 2), to form the corresponding 11- (3-tertiaryminopropyl) -derived; Y 4) Dealkylation of the derivative obtained in step 3). (Machine-translation by Google Translate, not legally binding)
ES0295106A1963-12-241963-12-24Procedure for the preparation of dibenzo (b, e) tiepinas (Machine-translation by Google Translate, not legally binding)
ExpiredES295106A1
(en)
A procedure for the preparation of a substantially hollow-free structure from a 1-olefin polymer (Machine-translation by Google Translate, not legally binding)