ES2822349T3 - Potenciador de la conservación - Google Patents
Potenciador de la conservación Download PDFInfo
- Publication number
- ES2822349T3 ES2822349T3 ES17205658T ES17205658T ES2822349T3 ES 2822349 T3 ES2822349 T3 ES 2822349T3 ES 17205658 T ES17205658 T ES 17205658T ES 17205658 T ES17205658 T ES 17205658T ES 2822349 T3 ES2822349 T3 ES 2822349T3
- Authority
- ES
- Spain
- Prior art keywords
- weight
- range
- erythrulose
- phytantriol
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000003623 enhancer Substances 0.000 title claims description 10
- 239000000203 mixture Substances 0.000 claims abstract description 89
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 claims abstract description 44
- CGIHFIDULQUVJG-VNTMZGSJSA-N phytantriol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(O)[C@H](O)CO CGIHFIDULQUVJG-VNTMZGSJSA-N 0.000 claims abstract description 42
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 claims abstract description 39
- 230000000699 topical effect Effects 0.000 claims abstract description 28
- 239000002537 cosmetic Substances 0.000 claims description 34
- 238000002360 preparation method Methods 0.000 claims description 31
- 241000588724 Escherichia coli Species 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 12
- 239000002453 shampoo Substances 0.000 claims description 12
- 238000004321 preservation Methods 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 239000000839 emulsion Substances 0.000 claims description 9
- 210000004761 scalp Anatomy 0.000 claims description 8
- 244000005714 skin microbiome Species 0.000 claims description 8
- 230000013632 homeostatic process Effects 0.000 claims description 6
- 230000036074 healthy skin Effects 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- -1 softeners Substances 0.000 description 18
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 14
- 239000003755 preservative agent Substances 0.000 description 14
- 239000000499 gel Substances 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 239000000194 fatty acid Substances 0.000 description 11
- 239000004480 active ingredient Substances 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 150000004665 fatty acids Chemical class 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000003995 emulsifying agent Substances 0.000 description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 8
- 230000002335 preservative effect Effects 0.000 description 8
- 238000011109 contamination Methods 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 239000006210 lotion Substances 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000002562 thickening agent Substances 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
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- 229920002545 silicone oil Polymers 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- UPOYFZYFGWBUKL-UHFFFAOYSA-N amiphenazole Chemical compound S1C(N)=NC(N)=C1C1=CC=CC=C1 UPOYFZYFGWBUKL-UHFFFAOYSA-N 0.000 description 4
- 229950001798 amiphenazole Drugs 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000007764 o/w emulsion Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000008491 skin homeostasis Effects 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000007762 w/o emulsion Substances 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- UQPHVQVXLPRNCX-VKHMYHEASA-N L-erythrulose Chemical compound OC[C@H](O)C(=O)CO UQPHVQVXLPRNCX-VKHMYHEASA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- OPVLOHUACNWTQT-UHFFFAOYSA-N azane;2-dodecoxyethyl hydrogen sulfate Chemical compound N.CCCCCCCCCCCCOCCOS(O)(=O)=O OPVLOHUACNWTQT-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
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- 150000001875 compounds Chemical class 0.000 description 2
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- 229920006037 cross link polymer Polymers 0.000 description 2
- 229940120503 dihydroxyacetone Drugs 0.000 description 2
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 description 2
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 229940075529 glyceryl stearate Drugs 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- ZUVCYFMOHFTGDM-UHFFFAOYSA-N hexadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(O)=O ZUVCYFMOHFTGDM-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
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- 230000000670 limiting effect Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Veterinary Medicine (AREA)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17205658.2A EP3494958B1 (en) | 2017-12-06 | 2017-12-06 | Preservation booster |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2822349T3 true ES2822349T3 (es) | 2021-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES17205658T Active ES2822349T3 (es) | 2017-12-06 | 2017-12-06 | Potenciador de la conservación |
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| EP (1) | EP3494958B1 (enExample) |
| JP (1) | JP7343089B2 (enExample) |
| KR (1) | KR102698105B1 (enExample) |
| CN (1) | CN109875906B (enExample) |
| ES (1) | ES2822349T3 (enExample) |
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| JP7114847B2 (ja) * | 2017-07-06 | 2022-08-09 | ディーエスエム アイピー アセッツ ビー．ブイ． | 新規な使用 |
| EP3735958A1 (en) * | 2019-05-10 | 2020-11-11 | DSM IP Assets B.V. | Topical compositions with preservation system |
| JP2021161046A (ja) * | 2020-03-31 | 2021-10-11 | 株式会社 資生堂 | 化粧料 |
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| DE3686022D1 (de) * | 1985-10-22 | 1992-08-20 | Silvetti Sen | Monosaccharide enthaltende zusammensetzung zum heilen von wunden. |
| AU4647300A (en) | 1999-04-19 | 2000-11-02 | Procter & Gamble Company, The | Skin care compositions containing combination of skin care actives |
| FR2809954B1 (fr) | 2000-06-08 | 2004-03-12 | Oreal | Utilisation du phytantriol comme agent anti-pollution, notamment dans une composition cosmetique |
| EP1407757A1 (en) * | 2002-10-09 | 2004-04-14 | Ciba SC Holding AG | Preparation of micronised UV absorbers |
| FR2861989B1 (fr) * | 2003-11-07 | 2005-12-30 | Oreal | Utilisation cosmetique du phytantriol comme agent empechant ou reduisant l'adhesion des microorganismes sur la surface de la peau et/ou des muqueuses |
| US20050131077A1 (en) | 2003-11-07 | 2005-06-16 | L'oreal | Preventing or reducing the adhesion of microorganisms with phytanetriol |
| FR2927801B1 (fr) * | 2008-02-22 | 2010-03-05 | Sederma Sa | Composition cosmetique hydratante comprenant une combinaison d'homarine et d'erythritol |
| EP2320915B1 (en) | 2008-08-15 | 2014-04-23 | Xttrium Laboratories, Inc. | Gentle, non-irritating, non-alcohoholic skin disinfectant |
| US20120128602A1 (en) | 2010-11-19 | 2012-05-24 | Kao Corporation | Skin compositions containing low levels of colorants |
| JP6196235B2 (ja) * | 2011-12-21 | 2017-09-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 抗菌活性化合物としてのシクロヘキサノール誘導体の使用 |
| EP2846763B1 (de) * | 2012-05-08 | 2017-02-08 | Merck Patent GmbH | Verwendung von cyclohexanolethern mit antimikrobiellen eigenschaften |
| WO2012143576A2 (en) * | 2012-08-23 | 2012-10-26 | Symrise Ag | Compounds for preventing, reducing and/or alleviating itchy skin condition(s) |
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Also Published As
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| JP2019108325A (ja) | 2019-07-04 |
| EP3494958B1 (en) | 2020-07-29 |
| US20190167549A1 (en) | 2019-06-06 |
| KR20190067102A (ko) | 2019-06-14 |
| KR102698105B1 (ko) | 2024-08-23 |
| US10933002B2 (en) | 2021-03-02 |
| EP3494958A1 (en) | 2019-06-12 |
| JP7343089B2 (ja) | 2023-09-12 |
| BR102018075165A2 (pt) | 2019-06-25 |
| CN109875906B (zh) | 2023-03-31 |
| CN109875906A (zh) | 2019-06-14 |
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