ES279152A1 - A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES279152A1 ES279152A1 ES279152A ES279152A ES279152A1 ES 279152 A1 ES279152 A1 ES 279152A1 ES 279152 A ES279152 A ES 279152A ES 279152 A ES279152 A ES 279152A ES 279152 A1 ES279152 A1 ES 279152A1
- Authority
- ES
- Spain
- Prior art keywords
- oxo
- translation
- convert
- primary
- legally binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D459/00—Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A process for producing 17-oxo-yohimban derivatives or alloyohimban derivatives having a methylene group substituted at the 16 or 18 position of the E-ring, said methylene group being of the formula ** (See formula) ** wherein Y is OH, OR, OC-R, OC-aryl, SR, a primary or secondary amine, in which R is a lower alkyl group and the aryl group is a phenyl or naphthyl radical with the proviso that when the substituted methylene group is in position 16, the hydrogen of C20 has the alpha configuration, and its pharmaceutically acceptable salts, characterized in that (a) a yohimban-17-one or alloyohimban-17-one is condensed with an alkyl formate lower in the presence of a Claisen-type condensation reagent to form the corresponding 16- and/or 18-hydroxymethylene derivative (in which Y is OH) and (b) if desired, the hydroxymethylene derivative thus formed is condensed from the lower way (RSH) in the presence of an acid catalyst to convert Y to -OR or -SR; (2) a primary or secondary amine to convert Y to a primary or secondary amine radical; (3) a group capable of providing the radicals (see formula) to convert Y into (see formula) (o) and, furthermore, if desired, the acid addition salts of the above are formed. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15725161A | 1961-12-05 | 1961-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES279152A1 true ES279152A1 (en) | 1962-11-01 |
Family
ID=22562952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES279152A Expired ES279152A1 (en) | 1961-12-05 | 1962-07-12 | A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT260428B (en) |
| BE (1) | BE620499A (en) |
| BR (1) | BR6241303D0 (en) |
| CH (1) | CH415659A (en) |
| DE (1) | DE1445411A1 (en) |
| DK (2) | DK107230C (en) |
| ES (1) | ES279152A1 (en) |
| GB (1) | GB1001346A (en) |
-
1962
- 1962-07-10 GB GB2643062A patent/GB1001346A/en not_active Expired
- 1962-07-12 ES ES279152A patent/ES279152A1/en not_active Expired
- 1962-07-19 DE DE19621445411 patent/DE1445411A1/en active Pending
- 1962-07-20 CH CH875562A patent/CH415659A/en unknown
- 1962-07-20 BE BE620499A patent/BE620499A/en unknown
- 1962-07-23 AT AT593862A patent/AT260428B/en active
- 1962-07-24 DK DK554463A patent/DK107230C/en active
- 1962-07-24 DK DK330262A patent/DK108792C/en active
- 1962-07-25 BR BR14130362A patent/BR6241303D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR6241303D0 (en) | 1973-06-14 |
| AT260428B (en) | 1968-03-11 |
| BE620499A (en) | 1963-01-21 |
| DK107230C (en) | 1967-05-08 |
| CH415659A (en) | 1966-06-30 |
| DK108792C (en) | 1968-02-12 |
| DE1445411A1 (en) | 1968-10-31 |
| GB1001346A (en) | 1965-08-18 |
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