ES279152A1 - A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES279152A1
ES279152A1 ES279152A ES279152A ES279152A1 ES 279152 A1 ES279152 A1 ES 279152A1 ES 279152 A ES279152 A ES 279152A ES 279152 A ES279152 A ES 279152A ES 279152 A1 ES279152 A1 ES 279152A1
Authority
ES
Spain
Prior art keywords
oxo
translation
convert
primary
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES279152A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES279152A1 publication Critical patent/ES279152A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D459/00Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A process for producing 17-oxo-yohimban derivatives or alloyohimban derivatives having a methylene group substituted at the 16 or 18 position of the E-ring, said methylene group being of the formula ** (See formula) ** wherein Y is OH, OR, OC-R, OC-aryl, SR, a primary or secondary amine, in which R is a lower alkyl group and the aryl group is a phenyl or naphthyl radical with the proviso that when the substituted methylene group is in position 16, the hydrogen of C20 has the alpha configuration, and its pharmaceutically acceptable salts, characterized in that (a) a yohimban-17-one or alloyohimban-17-one is condensed with an alkyl formate lower in the presence of a Claisen-type condensation reagent to form the corresponding 16- and/or 18-hydroxymethylene derivative (in which Y is OH) and (b) if desired, the hydroxymethylene derivative thus formed is condensed from the lower way (RSH) in the presence of an acid catalyst to convert Y to -OR or -SR; (2) a primary or secondary amine to convert Y to a primary or secondary amine radical; (3) a group capable of providing the radicals (see formula) to convert Y into (see formula) (o) and, furthermore, if desired, the acid addition salts of the above are formed. (Machine-translation by Google Translate, not legally binding)
ES279152A 1961-12-05 1962-07-12 A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding) Expired ES279152A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15725161A 1961-12-05 1961-12-05

Publications (1)

Publication Number Publication Date
ES279152A1 true ES279152A1 (en) 1962-11-01

Family

ID=22562952

Family Applications (1)

Application Number Title Priority Date Filing Date
ES279152A Expired ES279152A1 (en) 1961-12-05 1962-07-12 A procedure for producing derivatives of 17-oxo-yohim-bano or aloyohimbano (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
AT (1) AT260428B (en)
BE (1) BE620499A (en)
BR (1) BR6241303D0 (en)
CH (1) CH415659A (en)
DE (1) DE1445411A1 (en)
DK (2) DK107230C (en)
ES (1) ES279152A1 (en)
GB (1) GB1001346A (en)

Also Published As

Publication number Publication date
BR6241303D0 (en) 1973-06-14
AT260428B (en) 1968-03-11
BE620499A (en) 1963-01-21
DK107230C (en) 1967-05-08
CH415659A (en) 1966-06-30
DK108792C (en) 1968-02-12
DE1445411A1 (en) 1968-10-31
GB1001346A (en) 1965-08-18

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