ES2663724T3 - Dispositivo para reducir los efectos de la absorción de energía por agitación mediante la reducción del flujo sanguíneo desde el cráneo - Google Patents
Dispositivo para reducir los efectos de la absorción de energía por agitación mediante la reducción del flujo sanguíneo desde el cráneo Download PDFInfo
- Publication number
- ES2663724T3 ES2663724T3 ES11834865.5T ES11834865T ES2663724T3 ES 2663724 T3 ES2663724 T3 ES 2663724T3 ES 11834865 T ES11834865 T ES 11834865T ES 2663724 T3 ES2663724 T3 ES 2663724T3
- Authority
- ES
- Spain
- Prior art keywords
- neck
- pressure
- collar
- blood
- agitation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000003625 skull Anatomy 0.000 title claims abstract description 32
- 238000013019 agitation Methods 0.000 title description 39
- 238000010521 absorption reaction Methods 0.000 title description 32
- 230000000694 effects Effects 0.000 title description 15
- 230000017531 blood circulation Effects 0.000 title description 11
- 210000004731 jugular vein Anatomy 0.000 claims abstract description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 140
- 229910002092 carbon dioxide Inorganic materials 0.000 description 70
- 210000003739 neck Anatomy 0.000 description 64
- 230000006835 compression Effects 0.000 description 57
- 238000007906 compression Methods 0.000 description 57
- 210000004369 blood Anatomy 0.000 description 51
- 239000008280 blood Substances 0.000 description 51
- 238000000034 method Methods 0.000 description 41
- 241001465754 Metazoa Species 0.000 description 39
- 206010001497 Agitation Diseases 0.000 description 38
- 238000007917 intracranial administration Methods 0.000 description 38
- 230000009102 absorption Effects 0.000 description 31
- 239000007789 gas Substances 0.000 description 31
- 210000004556 brain Anatomy 0.000 description 26
- 208000027418 Wounds and injury Diseases 0.000 description 25
- 230000004410 intraocular pressure Effects 0.000 description 22
- 210000003462 vein Anatomy 0.000 description 22
- 230000006378 damage Effects 0.000 description 20
- 210000003743 erythrocyte Anatomy 0.000 description 19
- 239000012530 fluid Substances 0.000 description 19
- 208000014674 injury Diseases 0.000 description 19
- 229920006375 polyphtalamide Polymers 0.000 description 19
- 210000003050 axon Anatomy 0.000 description 17
- 239000003570 air Substances 0.000 description 15
- 108010054147 Hemoglobins Proteins 0.000 description 14
- 102000001554 Hemoglobins Human genes 0.000 description 14
- 230000009467 reduction Effects 0.000 description 14
- 208000030886 Traumatic Brain injury Diseases 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 13
- 230000009529 traumatic brain injury Effects 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 12
- 230000002490 cerebral effect Effects 0.000 description 12
- 206010020591 Hypercapnia Diseases 0.000 description 11
- 230000033001 locomotion Effects 0.000 description 11
- 238000009423 ventilation Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 230000001133 acceleration Effects 0.000 description 9
- 230000003376 axonal effect Effects 0.000 description 9
- 230000003902 lesion Effects 0.000 description 9
- 230000007246 mechanism Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000002685 pulmonary effect Effects 0.000 description 9
- 230000000241 respiratory effect Effects 0.000 description 9
- 108010061951 Methemoglobin Proteins 0.000 description 8
- 241000700159 Rattus Species 0.000 description 8
- 206010052428 Wound Diseases 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 238000004891 communication Methods 0.000 description 8
- 230000007423 decrease Effects 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 210000002832 shoulder Anatomy 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 210000002804 pyramidal tract Anatomy 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 206010019196 Head injury Diseases 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 5
- 208000029028 brain injury Diseases 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 210000003128 head Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000000116 mitigating effect Effects 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- -1 progesterone Chemical class 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 230000035939 shock Effects 0.000 description 5
- 206010002091 Anaesthesia Diseases 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 4
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000003727 cerebral blood flow Effects 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 3
- 206010010254 Concussion Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 229920002334 Spandex Polymers 0.000 description 3
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 description 3
- 210000005013 brain tissue Anatomy 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 230000009514 concussion Effects 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000013013 elastic material Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 150000003278 haem Chemical class 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
- 229960000907 methylthioninium chloride Drugs 0.000 description 3
- 238000012806 monitoring device Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 230000000472 traumatic effect Effects 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- XOHUEYCVLUUEJJ-UHFFFAOYSA-I 2,3-Diphosphoglycerate Chemical compound [O-]P(=O)([O-])OC(C(=O)[O-])COP([O-])([O-])=O XOHUEYCVLUUEJJ-UHFFFAOYSA-I 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 102000016899 Cytochrome-B(5) Reductase Human genes 0.000 description 2
- 108010028689 Cytochrome-B(5) Reductase Proteins 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229930040373 Paraformaldehyde Natural products 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000000133 brain stem Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229940090949 docosahexaenoic acid Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000002055 immunohistochemical effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000395 magnesium oxide Substances 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 210000000944 nerve tissue Anatomy 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000003961 neuronal insult Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920002866 paraformaldehyde Polymers 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 229920001084 poly(chloroprene) Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 210000001147 pulmonary artery Anatomy 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 235000019192 riboflavin Nutrition 0.000 description 2
- 239000002151 riboflavin Substances 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000004759 spandex Substances 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 238000013222 sprague-dawley male rat Methods 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 description 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 1
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
- 101100243025 Arabidopsis thaliana PCO2 gene Proteins 0.000 description 1
- 208000013883 Blast injury Diseases 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 235000015842 Hesperis Nutrition 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 235000012633 Iberis amara Nutrition 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 229920000271 Kevlar® Polymers 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 229920002396 Polyurea Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 206010038687 Respiratory distress Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229960000571 acetazolamide Drugs 0.000 description 1
- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 description 1
- 210000001361 achilles tendon Anatomy 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000004760 aramid Substances 0.000 description 1
- 229920003235 aromatic polyamide Polymers 0.000 description 1
- 230000008321 arterial blood flow Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000007844 axonal damage Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 210000001608 connective tissue cell Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 208000029039 cyanide poisoning Diseases 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 1
- 229960003933 dorzolamide Drugs 0.000 description 1
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000002518 glial effect Effects 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000037183 heart physiology Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000004761 kevlar Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 238000009593 lumbar puncture Methods 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 210000005171 mammalian brain Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- 229960004083 methazolamide Drugs 0.000 description 1
- FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 description 1
- 208000005135 methemoglobinemia Diseases 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 description 1
- 229960004023 minocycline Drugs 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000008518 non respiratory effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920002113 octoxynol Polymers 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 230000002746 orthostatic effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- CMFNMSMUKZHDEY-UHFFFAOYSA-N peroxynitrous acid Chemical compound OON=O CMFNMSMUKZHDEY-UHFFFAOYSA-N 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229940063222 provera Drugs 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 210000003492 pulmonary vein Anatomy 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010245 stereological analysis Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008718 systemic inflammatory response Effects 0.000 description 1
- 230000004873 systolic arterial blood pressure Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229960004394 topiramate Drugs 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/0512—Neck or shoulders area
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/132—Tourniquets
- A61B17/1322—Tourniquets comprising a flexible encircling member
- A61B17/1325—Tourniquets comprising a flexible encircling member with means for applying local pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/132—Tourniquets
- A61B17/135—Tourniquets inflatable
-
- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B2225/00—Miscellaneous features of sport apparatus, devices or equipment
- A63B2225/62—Inflatable
-
- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B71/00—Games or sports accessories not covered in groups A63B1/00 - A63B69/00
- A63B71/08—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions
- A63B71/081—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions fluid-filled, e.g. air-filled
-
- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B71/00—Games or sports accessories not covered in groups A63B1/00 - A63B69/00
- A63B71/08—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions
- A63B71/10—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions for the head
-
- A—HUMAN NECESSITIES
- A63—SPORTS; GAMES; AMUSEMENTS
- A63B—APPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
- A63B71/00—Games or sports accessories not covered in groups A63B1/00 - A63B69/00
- A63B71/08—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions
- A63B71/12—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions for the body or the legs, e.g. for the shoulders
- A63B71/1291—Body-protectors for players or sportsmen, i.e. body-protecting accessories affording protection of body parts against blows or collisions for the body or the legs, e.g. for the shoulders for the neck
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Physical Education & Sports Medicine (AREA)
- Textile Engineering (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Instructional Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Percussion Or Vibration Massage (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US931415 | 1978-08-07 | ||
| US12/931,415 US9168045B2 (en) | 2009-09-11 | 2011-02-01 | Device to reduce SLOSH energy absorption and its damaging effects through the reduction of the flow of one or more outflow vessels of the cranium |
| US201161518117P | 2011-04-29 | 2011-04-29 | |
| US201161518117P | 2011-04-29 | ||
| PCT/US2011/055783 WO2012054262A1 (en) | 2010-09-10 | 2011-10-11 | Methods and device to reduce slosh energy absorption effects by reducing blood flow from the cranium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2663724T3 true ES2663724T3 (es) | 2018-04-16 |
Family
ID=45975561
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11834865.5T Active ES2663724T3 (es) | 2011-02-01 | 2011-10-11 | Dispositivo para reducir los efectos de la absorción de energía por agitación mediante la reducción del flujo sanguíneo desde el cráneo |
| ES22211562T Active ES3031699T3 (en) | 2011-02-01 | 2011-10-11 | Device to reduce slosh energy absorption effects by reducing blood flow from the cranium |
| ES12840429T Active ES2804673T3 (es) | 2011-02-01 | 2012-06-06 | Dispositivo para reducir los efectos dañinos de fuerzas de ondas expansivas de explosiones o que provoquen conmoción cerebral en un sujeto |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES22211562T Active ES3031699T3 (en) | 2011-02-01 | 2011-10-11 | Device to reduce slosh energy absorption effects by reducing blood flow from the cranium |
| ES12840429T Active ES2804673T3 (es) | 2011-02-01 | 2012-06-06 | Dispositivo para reducir los efectos dañinos de fuerzas de ondas expansivas de explosiones o que provoquen conmoción cerebral en un sujeto |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP2637927B1 (https=) |
| AU (3) | AU2011318427B2 (https=) |
| CA (1) | CA2823184C (https=) |
| DK (1) | DK2637927T3 (https=) |
| EA (1) | EA025570B1 (https=) |
| ES (3) | ES2663724T3 (https=) |
| IN (1) | IN2015DN00008A (https=) |
| NZ (1) | NZ613566A (https=) |
| PL (1) | PL2637927T3 (https=) |
| PT (1) | PT2637927T (https=) |
| WO (1) | WO2012054262A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10842502B2 (en) * | 2009-09-11 | 2020-11-24 | Tbi Innovations, Llc | Devices and systems to mitigate traumatic brain and other injuries caused by concussive or blast forces |
| US9168045B2 (en) | 2009-09-11 | 2015-10-27 | Tbi Innovations, Llc | Device to reduce SLOSH energy absorption and its damaging effects through the reduction of the flow of one or more outflow vessels of the cranium |
| US8985120B2 (en) | 2009-09-11 | 2015-03-24 | Tbi Innovations, Llc | Method to reduce SLOSH energy absorption and its damaging effects through the reduction of inelastic collisions in an organism |
| US9173660B2 (en) | 2009-09-11 | 2015-11-03 | Tbi Innovations, Llc | Methods and devices to reduce the likelihood of injury from concussive or blast forces |
| US11696766B2 (en) | 2009-09-11 | 2023-07-11 | Tbi Innovations, Llc | Methods and devices to reduce damaging effects of concussive or blast forces on a subject |
| US10004515B2 (en) | 2009-09-11 | 2018-06-26 | Tbi Innovations, Llc | Methods and devices to reduce damaging effects of concussive or blast forces on a subject |
| US8900169B2 (en) | 2013-03-15 | 2014-12-02 | Tbi Innovations, Llc | Methods and devices to reduce the likelihood of injury from concussive or blast forces |
| US10188159B2 (en) | 2013-10-25 | 2019-01-29 | Armour Technologies, Inc. | Apparatus, system, and method for reducing head or neck trauma |
| US9901722B2 (en) | 2014-06-01 | 2018-02-27 | White Swell Medical Ltd | System and method for treatment of pulmonary edema |
| IL294513B2 (en) | 2015-05-11 | 2024-10-01 | White Swell Medical Ltd | Systems and methods for reducing pressure at an outflow of a duct |
| AU2016355540B2 (en) | 2015-11-16 | 2021-02-18 | Q30 Sports Science, Llc | Traumatic brain injury protection devices |
| CA3016454A1 (en) | 2016-03-02 | 2017-09-08 | Q30 Sports Science, Llc | Methods and devices to reduce damaging effects of concussive or blast forces on a subject |
| AU2017353938B2 (en) | 2016-11-01 | 2022-10-20 | White Swell Medical Ltd | Systems and methods for treatment of fluid overload |
| WO2018158636A1 (en) | 2017-03-02 | 2018-09-07 | White Swell Medical Ltd | Systems and methods for reducing pressure at outflow of a duct |
| US11406393B2 (en) | 2017-03-19 | 2022-08-09 | White Swell Medical Ltd | Methods and devices for reducing pressure |
| EP3752237A4 (en) | 2018-02-13 | 2021-11-17 | White Swell Medical Ltd | INTRAVASCULAR CATHETERS |
| US11660426B2 (en) | 2019-02-26 | 2023-05-30 | White Swell Medical Ltd | Devices and methods for treating edema |
| US11717652B2 (en) | 2019-02-26 | 2023-08-08 | White Swell Medical Ltd | Devices and methods for treating edema |
| US11931560B2 (en) | 2019-02-26 | 2024-03-19 | White Swell Medical Ltd | Devices and methods for treating edema |
| US11793996B2 (en) | 2019-02-26 | 2023-10-24 | White Swell Medical Ltd | Devices and methods for treating edema |
| US11724095B2 (en) | 2019-02-26 | 2023-08-15 | White Swell Medical Ltd | Devices and methods for treating edema |
| EP4034219B1 (en) | 2019-09-25 | 2025-11-19 | White Swell Medical Ltd | Devices and methods for interstitial decongestion |
| US20210378678A1 (en) | 2020-06-08 | 2021-12-09 | White Swell Medical Ltd | Non-thrombogenic devices for treating edema |
| IL301495A (en) | 2020-10-01 | 2023-05-01 | White Swell Medical Ltd | Intravascular devices that limit flow to treat edema |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR719730A (fr) * | 1931-07-08 | 1932-02-09 | Appareil compressif contre le mal de mer | |
| US2271927A (en) | 1938-06-16 | 1942-02-03 | Edward S Saighman | Tourniquet |
| US2676586A (en) * | 1942-06-24 | 1954-04-27 | Jr Charles A Coakwell | Blackout-preventing device |
| US3628536A (en) * | 1969-08-15 | 1971-12-21 | Otto N Glesne | Tourniquet |
| US3765412A (en) * | 1971-12-23 | 1973-10-16 | Department Of Health Education | Inflatable cervical collar for prevention of head and neck injury |
| US4204547A (en) * | 1978-11-13 | 1980-05-27 | Allocca John A | Method and apparatus for noninvasive monitoring of intracranial pressure |
| US4628926A (en) * | 1982-12-28 | 1986-12-16 | Products For Health And Industry, Inc. | Carbon dioxide rebreathing apparatus |
| US5584853A (en) * | 1990-01-29 | 1996-12-17 | Mcewen; James A. | Tourniquet cuff apparatus |
| US5403266A (en) * | 1993-07-06 | 1995-04-04 | United States Manufacturing Company | Inflatable cervical traction collar |
| US5413582A (en) * | 1993-11-03 | 1995-05-09 | Electromedics, Inc. | Inflatable tourniquet cuff and method of making same |
| US5643315A (en) | 1994-09-22 | 1997-07-01 | Daneshvar; Yousef | Device for wound therapy and prevention of bleeding |
| WO1998046144A1 (en) | 1997-04-14 | 1998-10-22 | Advanced Closure Systems, Inc. | Feedback controlled disposable hemostasis device |
| GB9802588D0 (en) * | 1998-02-07 | 1998-04-01 | Fisher Peter | Inflatable collar |
| US7100251B2 (en) * | 2002-03-21 | 2006-09-05 | Iilinois Tool Works, Inc. | Breakaway buckle |
| US8357831B2 (en) * | 2003-02-04 | 2013-01-22 | Buckman Robert F | Surgical packing devices |
| US7048705B2 (en) * | 2004-07-13 | 2006-05-23 | Bala Hari Pillai | Traction adjustable cervical collar for transferring weight of the head of a wearer from the cervical spine of the wearer to the shoulders of the wearer |
| US20060200195A1 (en) * | 2005-02-25 | 2006-09-07 | Chang-Ming Yang | Aspiration and delivery safety system |
| WO2007074350A1 (en) * | 2005-12-28 | 2007-07-05 | Andrea Marinello | Device for the treatment of carotid artery diseases |
| US20100318114A1 (en) * | 2007-10-31 | 2010-12-16 | The Regents Of The University Of California | Venous Modulation of Collateral Perfusion of Cerebral Ischemia |
| US8191553B2 (en) * | 2008-06-30 | 2012-06-05 | Randal Haworth | Jaw thrust device |
-
2011
- 2011-10-11 PT PT118348655T patent/PT2637927T/pt unknown
- 2011-10-11 EA EA201391070A patent/EA025570B1/ru not_active IP Right Cessation
- 2011-10-11 WO PCT/US2011/055783 patent/WO2012054262A1/en not_active Ceased
- 2011-10-11 DK DK11834865.5T patent/DK2637927T3/en active
- 2011-10-11 ES ES11834865.5T patent/ES2663724T3/es active Active
- 2011-10-11 EP EP11834865.5A patent/EP2637927B1/en active Active
- 2011-10-11 AU AU2011318427A patent/AU2011318427B2/en active Active
- 2011-10-11 EP EP17208282.8A patent/EP3338574B1/en active Active
- 2011-10-11 ES ES22211562T patent/ES3031699T3/es active Active
- 2011-10-11 NZ NZ61356611A patent/NZ613566A/en unknown
- 2011-10-11 EP EP22211562.8A patent/EP4179904B1/en active Active
- 2011-10-11 CA CA2823184A patent/CA2823184C/en active Active
- 2011-10-11 PL PL11834865T patent/PL2637927T3/pl unknown
-
2012
- 2012-06-06 ES ES12840429T patent/ES2804673T3/es active Active
- 2012-06-06 IN IN8DEN2015 patent/IN2015DN00008A/en unknown
-
2016
- 2016-12-29 AU AU2016277766A patent/AU2016277766B2/en active Active
-
2019
- 2019-04-17 AU AU2019202685A patent/AU2019202685B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4179904A1 (en) | 2023-05-17 |
| PT2637927T (pt) | 2018-04-02 |
| AU2019202685B2 (en) | 2021-05-20 |
| ES2804673T3 (es) | 2021-02-09 |
| EP4179904B1 (en) | 2025-03-12 |
| EA201391070A1 (ru) | 2014-01-30 |
| EP2637927B1 (en) | 2018-01-03 |
| AU2016277766B2 (en) | 2019-01-31 |
| WO2012054262A1 (en) | 2012-04-26 |
| EP2637927A1 (en) | 2013-09-18 |
| EA025570B1 (ru) | 2017-01-30 |
| AU2016277766A1 (en) | 2017-02-02 |
| EP3338574B1 (en) | 2022-12-07 |
| AU2011318427A1 (en) | 2013-08-15 |
| CA2823184C (en) | 2015-09-22 |
| EP3338574A3 (en) | 2018-09-12 |
| ES3031699T3 (en) | 2025-07-10 |
| NZ613566A (en) | 2015-04-24 |
| AU2011318427B2 (en) | 2016-09-29 |
| EP2637927A4 (en) | 2014-10-15 |
| AU2019202685A1 (en) | 2019-05-09 |
| EP3338574A2 (en) | 2018-06-27 |
| DK2637927T3 (en) | 2018-04-16 |
| PL2637927T3 (pl) | 2018-07-31 |
| IN2015DN00008A (https=) | 2015-05-22 |
| CA2823184A1 (en) | 2012-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2663724T3 (es) | Dispositivo para reducir los efectos de la absorción de energía por agitación mediante la reducción del flujo sanguíneo desde el cráneo | |
| CA2966110C (en) | Methods and device to reduce slosh energy absorption effects by reducing blood flow from the cranium | |
| ES2851676T3 (es) | Dispositivos y sistemas para mitigar traumatismos craneoencefálicos y otras lesiones causadas por fuerzas de concusión o de explosión | |
| ES2716804T3 (es) | Procedimiento de oxigenación para recién nacidos y dispositivos para su uso | |
| ES2431013T3 (es) | Potenciación del rendimiento | |
| Beecher | Preparation of battle casualties for surgery | |
| Lee et al. | Caudal ropivacaine and ketamine for postoperative analgesia in children | |
| US9987020B2 (en) | Method to reduce SLOSH energy absorption and its damaging effects through the reduction of inelastic collisions in an organism | |
| BR112014030559B1 (pt) | Dispositivo para reduzir os efeitos prejudiciais de forças de concussão em um indivíduo | |
| ES2939818T3 (es) | Dispositivo para reducir los efectos de absorción de energía por agitación reduciendo el flujo sanguíneo procedente del cráneo | |
| Shaaban Ali et al. | Early release pattern of S100 protein as a marker of brain damage after warm cardiopulmonary bypass | |
| Turner et al. | Emergencies, Trauma, and Poisonings | |
| Haider et al. | 7.8 Abnormal cerebral blood flow regulation during 6o head-down tilt after sport-related concussion | |
| Horn et al. | 7.9 Central respiratory physiological dysfunction after clinical recovery in sport-related concussion | |
| Fyffe et al. | 7.6 The female athlete: a miserable minority or a missed opportunity? | |
| Wallis et al. | BEEN THERE, DONE THAT… | |
| Griswold | Traumatic causes of altered mental status | |
| Holleran et al. | NEUROLOGIC TRAUMA | |
| Manthey et al. | Scope of the problem |