ES259632A1 - Esters of cortical steroid hormones - Google Patents
Esters of cortical steroid hormonesInfo
- Publication number
- ES259632A1 ES259632A1 ES0259632A ES259632A ES259632A1 ES 259632 A1 ES259632 A1 ES 259632A1 ES 0259632 A ES0259632 A ES 0259632A ES 259632 A ES259632 A ES 259632A ES 259632 A1 ES259632 A1 ES 259632A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- esters
- ester
- anhydride
- steroid hormones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises esters of 17a -hydroxy- and 17a ,21-dihydroxy-3,20-diketo-4-pregnenes and the corresponding 1,4-pregnadienes with b -(p-alkoxyphenyl)-propionic acids of the general formula <FORM:0919830/IV (b)/1> wherein R represents an alkyl group containing 1 to 12 carbon atoms, and the preparation thereof by reacting the required steroid with the anhydride or the acid chloride of an acid of the above formula in a solvent such as pyridine, benzene, toluene, ether or chloroform at a temperature between 0 DEG C. and the boiling point of the reaction mixture, for a period between half an hour and 72 hours. When an acid anhydride is used as the esterifying agent, the reaction may be carried out in the presence of an acid catalyst such as p-toluenesulphonic acid. Thus the product may be a 17-ester of 17a -hydroxyprogesterone or a 21-ester of 11-desoxycorticosterone, cortisone, hydrocortisone, prednisone or prednisolone. Therapeutic compositions having hormonal activity suitable for injection contain as the active ingredient the esters defined above, e.g. dissolved in sesame or peanut oil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2452359A GB919830A (en) | 1959-07-16 | 1959-07-16 | Esters of cortical steroid hormones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES259632A1 true ES259632A1 (en) | 1960-12-01 |
Family
ID=10212996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0259632A Expired ES259632A1 (en) | 1959-07-16 | 1960-07-13 | Esters of cortical steroid hormones |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE593077A (en) |
| ES (1) | ES259632A1 (en) |
| GB (1) | GB919830A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1036870B (en) * | 1975-02-13 | 1979-10-30 | Acraf | STEROID DERIVATIVES OF BENDAZOLIC ACID |
-
1959
- 1959-07-16 GB GB2452359A patent/GB919830A/en not_active Expired
-
1960
- 1960-07-13 ES ES0259632A patent/ES259632A1/en not_active Expired
- 1960-07-15 BE BE593077A patent/BE593077A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB919830A (en) | 1963-02-27 |
| BE593077A (en) | 1960-10-31 |
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