ES2581480T3 - Compuestos inhibidores de crecimiento tumoral y métodos de uso de los mismos - Google Patents
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US92758407P | 2007-05-04 | 2007-05-04 | |
| US927584P | 2007-05-04 |
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| ES2581480T3 true ES2581480T3 (es) | 2016-09-06 |
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| EP2656850B1 (en) * | 2007-10-05 | 2016-07-27 | InDex Pharmaceuticals AB | Oligonucleotides for the treatment or alleviation of edema |
| US20110182880A1 (en) * | 2008-06-18 | 2011-07-28 | Oliver Von Stein | Combination Therapies Against Cancer |
| JP5749651B2 (ja) | 2008-11-04 | 2015-07-15 | インデックス・ファーマシューティカルズ・アクチエボラーグ | 多形核細胞の動員および／または遊走を減少させる化合物および方法 |
| AU2009311753B2 (en) * | 2008-11-04 | 2015-01-15 | Index Pharmaceuticals Ab | Compounds and methods for the treatment of inflammatory diseases of the CNS |
| US9157919B2 (en) * | 2010-12-21 | 2015-10-13 | Index Pharmaceuticals Ab | Method for identifying biologically active oligonucleotides capable of modulating the immune system |
| WO2018174140A1 (ja) * | 2017-03-23 | 2018-09-27 | ナパジェン ファーマ，インコーポレテッド | 癌細胞の接着活性阻害剤 |
| EP3967307A1 (en) | 2020-09-15 | 2022-03-16 | Instytut Hematologii I Transfuzologii | Use of pim kinase inhibitors to augment the efficacy of anti-cd20 antibody-based therapies in hematologic malignancies and non-malignant conditions |
| KR20240006547A (ko) * | 2021-05-04 | 2024-01-15 | 주식회사 애스톤사이언스 | Her2 백신 조성물 |
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| US6498147B2 (en) | 1992-05-22 | 2002-12-24 | The Scripps Research Institute | Suppression of nuclear factor-κb dependent processes using oligonucleotides |
| EP0772619B2 (en) * | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| WO2000061151A2 (en) * | 1999-04-12 | 2000-10-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US7534772B2 (en) * | 2000-06-22 | 2009-05-19 | University Of Iowa Research Foundation | Methods for enhancing antibody-induced cell lysis and treating cancer |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| BRPI0416079A (pt) * | 2003-10-30 | 2007-01-02 | Coley Pharm Gmbh | análogos de oligonucleotìdeos de classe c com uma potência imunoestimuladora aumentada |
| MY159370A (en) * | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| EP2656850B1 (en) * | 2007-10-05 | 2016-07-27 | InDex Pharmaceuticals AB | Oligonucleotides for the treatment or alleviation of edema |
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Also Published As
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| JP5844779B2 (ja) | 2016-01-20 |
| EP2573176B1 (en) | 2016-04-06 |
| WO2008136748A1 (en) | 2008-11-13 |
| EP2160465A4 (en) | 2011-04-13 |
| EP2573176A1 (en) | 2013-03-27 |
| JP5346923B2 (ja) | 2013-11-20 |
| DK2573176T3 (en) | 2016-08-01 |
| US20100196356A1 (en) | 2010-08-05 |
| JP2013255508A (ja) | 2013-12-26 |
| EP2160465A1 (en) | 2010-03-10 |
| EP2160465B1 (en) | 2013-01-02 |
| US8309529B2 (en) | 2012-11-13 |
| WO2008136748A8 (en) | 2009-07-23 |
| JP2010525811A (ja) | 2010-07-29 |
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