ES2571933T3 - Improved method to synthesize modeled molecules - Google Patents

Improved method to synthesize modeled molecules

Info

Publication number
ES2571933T3
ES2571933T3 ES08169346T ES08169346T ES2571933T3 ES 2571933 T3 ES2571933 T3 ES 2571933T3 ES 08169346 T ES08169346 T ES 08169346T ES 08169346 T ES08169346 T ES 08169346T ES 2571933 T3 ES2571933 T3 ES 2571933T3
Authority
ES
Spain
Prior art keywords
monofunctional
trifunctional
heterocycles
difunctional
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES08169346T
Other languages
Spanish (es)
Inventor
Henrik Pedersen
Anette Holtmann
Thomas Franch
Alex Haahr Gouliaev
Jakob Felding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuevolution AS
Original Assignee
Nuevolution AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2002/000419 external-priority patent/WO2002103008A2/en
Priority claimed from US10/175,539 external-priority patent/US7727713B2/en
Application filed by Nuevolution AS filed Critical Nuevolution AS
Application granted granted Critical
Publication of ES2571933T3 publication Critical patent/ES2571933T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Control Of Eletrric Generators (AREA)

Abstract

Una biblioteca de diferentes complejos bifuncionales, donde cada complejo bifuncional comprende a una molécula portada que está adherida covalentemente a una plantilla de nucleótidos y que está adherida covalentemente a una plantilla complementaria de nucleótidos, Donde el número de diferentes complejos bifuncionales en la biblioteca es de por lo menos 103, Donde las moléculas portadas son seleccionadas de un grupo que consiste de policiclos alifáticos; policiclos aromáticos; poliheterociclos; hidrocarbonos de cadena abierta monofuncionales, difuncionales, o trifuncionales; carbociclos no aromáticos monofuncionales, difuncionales o trifuncionales; hidrocarbonos monocíclicos, bicíclicos o tricíclicos; hidrocarbonos policíclicos conectados; heterociclos no aromáticos monofuncionales, difucnioanles, o trifuncionales; heterociclos monocíclicos, bicíclicos o tricíclicos; heterociclos policíclicos conectados; carbociclos aromáticos monofuncionales, difuncionales o trifuncionales; carbociclos aromáticos monocíclicos, bicíclicos o tricíclicos; heterociclos monofuncionales, difuncionales o trifuncionales; heterociclos monocíclicos, bicíclicos o tricíclicos; quelatos; fullerenos; esteroides; y análogos de ciclosporina, y Donde una plantilla de nucleótidos enlazada a una molécula portada permite una identificación de la molécula portada por medio de una determinación de la secuencia de nucleótidos de la plantilla de nucleótidos.A library of different bifunctional complexes, where each bifunctional complex comprises a cover molecule that is covalently adhered to a nucleotide template and that is covalently adhered to a complementary nucleotide template, where the number of different bifunctional complexes in the library is per at least 103, where the carrier molecules are selected from a group consisting of aliphatic polycycles; aromatic polycycles; polyheterocycles; monofunctional, difunctional, or trifunctional open chain hydrocarbons; monofunctional, difunctional or trifunctional non-aromatic carbocycles; monocyclic, bicyclic or tricyclic hydrocarbons; connected polycyclic hydrocarbons; monofunctional, difucnioanles, or trifunctional non-aromatic heterocycles; monocyclic, bicyclic or tricyclic heterocycles; connected polycyclic heterocycles; monofunctional, difunctional or trifunctional aromatic carbocycles; monocyclic, bicyclic or tricyclic aromatic carbocycles; monofunctional, difunctional or trifunctional heterocycles; monocyclic, bicyclic or tricyclic heterocycles; chelates; fullerenes; steroids; and cyclosporine analogs, and Where a nucleotide template linked to a carrier molecule allows identification of the carrier molecule through a determination of the nucleotide sequence of the nucleotide template.

ES08169346T 2002-03-15 2003-03-14 Improved method to synthesize modeled molecules Expired - Lifetime ES2571933T3 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US36405602P 2002-03-15 2002-03-15
DKPA200200415 2002-03-15
US38988502P 2002-06-20 2002-06-20
PCT/DK2002/000419 WO2002103008A2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules
US10/175,539 US7727713B2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules
DKPA200200952 2002-06-20
US40996802P 2002-09-12 2002-09-12
DKPA200201347 2002-09-12

Publications (1)

Publication Number Publication Date
ES2571933T3 true ES2571933T3 (en) 2016-05-27

Family

ID=44541444

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08169346T Expired - Lifetime ES2571933T3 (en) 2002-03-15 2003-03-14 Improved method to synthesize modeled molecules

Country Status (5)

Country Link
JP (1) JP4738741B2 (en)
DK (1) DK2186897T3 (en)
ES (1) ES2571933T3 (en)
HU (1) HUE027365T2 (en)
SI (1) SI2186897T1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7479472B1 (en) * 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
WO2000061775A1 (en) * 1999-04-08 2000-10-19 Pavel Sergeev Synthesis of biologically active compounds in cells
IL159268A0 (en) * 2001-06-20 2004-06-01 Nuevolution As Templated molecules and methods for using such molecules

Also Published As

Publication number Publication date
SI2186897T1 (en) 2016-06-30
HUE027365T2 (en) 2016-09-28
JP2005521365A (en) 2005-07-14
DK2186897T3 (en) 2016-05-30
JP4738741B2 (en) 2011-08-03

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