Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Priority to ES0255029ApriorityCriticalpatent/ES255029A1/es
Publication of ES255029A1publicationCriticalpatent/ES255029A1/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procedimiento para la preparación de derivados de 16alfa-metiloprogesterona, que comprende hacer reaccionar 11alfa-hidroxy-16 alfa-metiloprogesterona con un agente dehidratante para producir incremento elevado a 9 (11)-16alfa-metiloprogesterona, tratando este compuesto con un ácido hipohaloso en donde el halógeno tiene un peso atómico entre 35 y 80 para producir el correspondiente 9alfa-halo-11ß-hidroxy-16alfa-metiloprogesterona; poner en contacto interno este compuesto con un álkali para producir 9ß-11ß-óxido-16alfa-metiloprogesterona, y hacer reaccionar este compuesto con fluoruro de hidrógeno para producir 9alfa-fluoro-11ß-hidroxy-16alfa-metiloprogesterona.
ES0255029A1959-01-081959-01-08Procedimiento para la preparaciën de derivados de 16 alfa-metilo-progesterona
ExpiredES255029A1
(es)