ES2550105B2 - Lentes de contacto para conjuntivitis alérgica - Google Patents

Lentes de contacto para conjuntivitis alérgica Download PDF

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Publication number
ES2550105B2
ES2550105B2 ES201530906A ES201530906A ES2550105B2 ES 2550105 B2 ES2550105 B2 ES 2550105B2 ES 201530906 A ES201530906 A ES 201530906A ES 201530906 A ES201530906 A ES 201530906A ES 2550105 B2 ES2550105 B2 ES 2550105B2
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ES
Spain
Prior art keywords
allergic conjunctivitis
contact lenses
hydrogels
olopatadine
hema
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ES201530906A
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English (en)
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ES2550105A1 (es
Inventor
Carmen ÁLVAREZ LORENZO
Clara GONZÁLEZ CHOMON
Ángel CONCHEIRO NINE
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Universidade de Santiago de Compostela
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Universidade de Santiago de Compostela
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Priority to ES201530906A priority Critical patent/ES2550105B2/es
Publication of ES2550105A1 publication Critical patent/ES2550105A1/es
Priority to PCT/ES2016/070466 priority patent/WO2016207460A1/es
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1807—C7-(meth)acrylate, e.g. heptyl (meth)acrylate or benzyl (meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/10—Homopolymers or copolymers of methacrylic acid esters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Lentes de contacto para conjuntivitis alérgica. La presente invención se refiere a hidrogeles, sistemas de liberación y dispositivos ópticos adecuados para el tratamiento o prevención de la conjuntivitis alérgica, en particular, la conjuntivitis alérgica estacional. Los hidrogeles de la invención son útiles en lentes de contacto blandas, y para cargar principios activos antihistamínicos como olopatadina, ketotifeno o azelastina en una cantidad suficiente para provocar una respuesta de eficacia adecuada.

Description

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durante 24 horas y finalmente en agua otra semana. Finalmente, los discos se secaron a 70 ºC durante 12 h.
Tabla 1. Composición de los hidrogeles imprinted (hidrogeles con números pares) y no imprinted (hidrogeles con números impares). A todas las mezclas de monómeros se les incorporó 1 mL de DMSO y 0.00821 g de AIBN.
Hidrogel
HEMA (mL) Fármaco (g) AAc (µL) BzMA (µL) AAm (g) AMPSA (g) EGDMA (µL)
1
4 0 0 0 0 0 188.6
3
4 0 68.6 0 0.072 0 188.6
17
4 0 68.6 338.9 0 0 188.6
23
4 0 137.2 0 0.144 0 188.6
25
4 0 68.6 338.9 0 0.207 188.6
29
4 0 68.6 338.9 0.072 0.207 377.2
2
4 0.1869 0 0 0 0 188.6
4
4
0.1869 68.6 0 0.072 0 188.6
18
4 0.1869 68.6 338.9 0 0 188.6
24
4 0.1869 137.2 0 0.144 0 188.6
26A
4 0.1869 68.6 338.9 0 0.207 188.6
26B
4 0.0935 68.6 338.9 0 0.207 188.6
30A
4 0.1869 68.6 338.9 0.072 0.207 377.2
30B
4 0.0935 68.6 338.9 0.072 0.207 377.2
10 2. Caracterización de los hidrogeles A continuación se recogen los métodos empleados en la caracterización de los hidrogeles preparados, y los resultados.
2.1 Calorimetría diferencial de barrido (DSC)
15 Se llevaron a cabo análisis de DSC en un DSC Q-100 (TA Instruments, USA) equipado con un sistema de refrigeración. Fragmentos de discos secos (4-6 mg) se colocaron en cápsulas de aluminio y se sometieron a calefacción hasta 150ºC, se mantuvieron 5
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20 días. Los discos preparados con HEMA sin monómeros funcionales (hidrogeles 1 y 2) fueron capaces de incorporar 30 mg/g en los primeros 5 días y hasta 38 mg/g cuando alcanzaron el equilibrio. La cantidad de olopatadina que estos discos de HEMA fueron capaces de alojar en fase acuosa fue de 0.1 mg/g lo que significa que el coeficiente de 5 reparto de olopatadina entre la red polimérica y el agua es de 188 (tabla 3). La cantidad de olopatadina cargada por el hidrogel 1 está en concordancia con los datos publicados para Acuvue (J&J) sumergidas en Patanol (hidrocloruro de olopatadina disolución oftálmica al 0.1%) (N.L. Dassanayake, T. C. Carey, G. R. Owen. A Laboratory Model to Determine the Uptake and Release of Olopatadine by Soft Contact Lenses. Acta
10 Ophthalmol. Scand. 2000: 78: 16–17). Los hidrogeles que combinan AAc, BzMA y AMPSA (hidrogel 25) cargan olopatadina más rápido y en una cantidad dos veces mayor que los hidrogeles preparados solamente con HEMA (figura 3). Tabla 3. Datos de carga de olopatadina y coeficiente de reparto de olopatadina entre la
15 red polimérica y el agua.
Hidrogel
Olopatadina incorporada (mg/g) KN/W
1
38.51 188
3
39.34 192
17
52.05 255
23
52.27 255
25
79.42 389
29
87.22 427
2
37.25 182
4
46.39 227
18
41.87 205
24
50.64 248
26A
59.51 291
26B
69.15 339
30A
56.70 277
30B
85.64 420
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Claims (1)

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ES201530906A 2015-06-25 2015-06-25 Lentes de contacto para conjuntivitis alérgica Active ES2550105B2 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201530906A ES2550105B2 (es) 2015-06-25 2015-06-25 Lentes de contacto para conjuntivitis alérgica
PCT/ES2016/070466 WO2016207460A1 (es) 2015-06-25 2016-06-20 Lentes de contacto para conjuntivitis alérgica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201530906A ES2550105B2 (es) 2015-06-25 2015-06-25 Lentes de contacto para conjuntivitis alérgica

Publications (2)

Publication Number Publication Date
ES2550105A1 ES2550105A1 (es) 2015-11-04
ES2550105B2 true ES2550105B2 (es) 2016-10-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES201530906A Active ES2550105B2 (es) 2015-06-25 2015-06-25 Lentes de contacto para conjuntivitis alérgica

Country Status (2)

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ES (1) ES2550105B2 (es)
WO (1) WO2016207460A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106084116B (zh) * 2016-06-17 2019-02-05 宁波国际材料基因工程研究院有限公司 水凝胶及其制备方法，水凝胶的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123407A (en) * 1976-11-26 1978-10-31 American Optical Corporation Hydrophilic contact lens
MX2007009417A (es) * 2005-02-04 2007-08-17 Univ Auburn Sistema de suministro de farmaco de contacto.
US9389336B2 (en) * 2013-08-02 2016-07-12 Bausch & Lomb Incorporated Hydrogel monomer mix containing added water

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ES2550105A1 (es) 2015-11-04

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