ES2545929B2 - Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme - Google Patents

Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme Download PDF

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Publication number
ES2545929B2
ES2545929B2 ES201401058A ES201401058A ES2545929B2 ES 2545929 B2 ES2545929 B2 ES 2545929B2 ES 201401058 A ES201401058 A ES 201401058A ES 201401058 A ES201401058 A ES 201401058A ES 2545929 B2 ES2545929 B2 ES 2545929B2
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sod
enzyme
antibodies
antibody
inhibition
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ES201401058A
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Spanish (es)
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ES2545929A1 (en
Inventor
Juan Antonio GARCÍA RANEA
Miguel MEDINA TORRES
Javier Alejandro GARCÍA-VILAS GARCÍA
Juan Francisco MORILLA DOMÍNGUEZ
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Universidad de Malaga
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Universidad de Malaga
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Uso de anticuerpos frente a la enzima SOD-3 para la inhibición del proceso de la angiogénesis y aplicaciones de dichos anticuerpos y de dicha enzima SOD-3. La presente invención se refiere al uso de la enzima SOD-3 como nueva diana molecular en prevención, terapia y/o tratamiento de patologías que cursan con angiogénesis, como por ejemplo degeneración macular asociada a la edad, artritis reumatoide o psoriasis; así como al uso en prevención, terapia y/o tratamiento de dichas patologías de anticuerpos que se unen, reaccionan o reconocen específicamente a SOD-3, y que modulan, preferentemente que inhiben, la actividad de dicha enzima, particularmente la actividad de SOD-3 humana.Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme. The present invention relates to the use of the SOD-3 enzyme as a new molecular target in prevention, therapy and / or treatment of pathologies that occur with angiogenesis, such as age-related macular degeneration, rheumatoid arthritis or psoriasis; as well as the use in prevention, therapy and / or treatment of said antibody pathologies that bind, react or specifically recognize SOD-3, and that modulate, preferably that inhibit, the activity of said enzyme, particularly the activity of SOD- 3 human.

Claims (6)

REIVINDICACIONES 1. Uso de un anticuerpo que se une, reacciona o reconoce específicamente a la enzima SOD-3 que inhibe su actividad en prevención, terapia y/o tratamiento de patologías que cursan con angiogénesis. 5 1. Use of an antibody that specifically binds, reacts or recognizes the SOD-3 enzyme that inhibits its activity in prevention, therapy and / or treatment of pathologies that occur with angiogenesis. 5 2. Uso según la reivindicación anterior caracterizado por que el anticuerpo se une, reacciona o reconoce específicamente a la enzima SOD-3 humana. 2. Use according to the preceding claim characterized in that the antibody binds, reacts or specifically recognizes the human SOD-3 enzyme. 3. Uso según la reivindicación anterior caracterizado por que el anticuerpo se une, reacciona o reconoce específicamente el péptido WTGEDSAEPNSDSAEWIRD (SEQ ID NO:1), correspondiente a los aminoácidos 19-37 aminoterminales. 10 3. Use according to the preceding claim characterized in that the antibody specifically binds, reacts or recognizes the WTGEDSAEPNSDSAEWIRD peptide (SEQ ID NO: 1), corresponding to amino-terminal amino acids 19-37. 10 4. Uso según la reivindicación anterior caracterizado por que el anticuerpo es isotipo inmunoglobulina G. 4. Use according to the preceding claim characterized in that the antibody is immunoglobulin G isotype. 5. Uso según la reivindicación anterior caracterizado por que el anticuerpo es policlonal. 5. Use according to the preceding claim characterized in that the antibody is polyclonal. 6. Uso según la reivindicación anterior caracterizado por que el anticuerpo se ha producido en conejo. 15 6. Use according to the preceding claim characterized in that the antibody has been produced in rabbit. fifteen
ES201401058A 2014-12-23 2014-12-23 Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme Active ES2545929B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201401058A ES2545929B2 (en) 2014-12-23 2014-12-23 Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201401058A ES2545929B2 (en) 2014-12-23 2014-12-23 Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme

Publications (2)

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ES2545929A1 ES2545929A1 (en) 2015-09-16
ES2545929B2 true ES2545929B2 (en) 2016-07-15

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ES201401058A Active ES2545929B2 (en) 2014-12-23 2014-12-23 Use of antibodies against the SOD-3 enzyme for the inhibition of the angiogenesis process and applications of said antibodies and said SOD-3 enzyme

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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5581485B2 (en) * 2007-03-22 2014-09-03 インダストリーアカデミック コーポレーション ファンデーション， ザ カトリックユニバーシティ オブ コリア New use of EC-SOD and manufacturing method thereof

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