ES2541787A1 - Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents (Machine-translation by Google Translate, not legally binding) - Google Patents

Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents (Machine-translation by Google Translate, not legally binding) Download PDF

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Publication number
ES2541787A1
ES2541787A1 ES201400058A ES201400058A ES2541787A1 ES 2541787 A1 ES2541787 A1 ES 2541787A1 ES 201400058 A ES201400058 A ES 201400058A ES 201400058 A ES201400058 A ES 201400058A ES 2541787 A1 ES2541787 A1 ES 2541787A1
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ES
Spain
Prior art keywords
compounds
carbon nanotubes
contrast agents
formula
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201400058A
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Spanish (es)
Other versions
ES2541787B1 (en
Inventor
Paloma Ballesteros García
Viviana NEGRI
Daniel CALLE HERNÁNDEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Nacional de Educacion a Distancia UNED
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Nacional de Educacion a Distancia UNED
Universidad Autonoma de Madrid
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Priority to ES201400058A priority Critical patent/ES2541787B1/en
Publication of ES2541787A1 publication Critical patent/ES2541787A1/en
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Publication of ES2541787B1 publication Critical patent/ES2541787B1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/20—Polycyclic condensed hydrocarbons
    • C07C15/38—Polycyclic condensed hydrocarbons containing four rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents. Compounds comprising carbon nanotubes and paramagnetic gadolinium chelates (III), derivatives of 1,4,7,10-tetraaza-1,4,7,10-cyclododecanotetraacetic acid (dota). These compounds are useful as contrast agents for nuclear magnetic resonance, a technique used to obtain images for clinical diagnosis and to provide alternative anisotropic contrast agents to those commonly used. The present invention relates to compounds comprising carbon nanotubes and compounds of formula (I), where the presence of a pyrene ring is indispensable for the formation of adducts through bonds π - π with carbon nanotubes, mono or multilayer and of length between 150 and 300 nm. R is selected, inter alia, by aliphatic amides, diamino derivatives, polyethylene glycol, alkyl squarate, and polyethylene glycol derivatives linked to dota monoamide. Their pharmaceutical compositions are used as contrast agents in anisotropic magnetic resonance imaging. (Machine-translation by Google Translate, not legally binding)

Description

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Claims (1)

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ES201400058A 2014-01-23 2014-01-23 Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents Active ES2541787B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201400058A ES2541787B1 (en) 2014-01-23 2014-01-23 Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201400058A ES2541787B1 (en) 2014-01-23 2014-01-23 Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents

Publications (2)

Publication Number Publication Date
ES2541787A1 true ES2541787A1 (en) 2015-07-24
ES2541787B1 ES2541787B1 (en) 2016-05-03

Family

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ES201400058A Active ES2541787B1 (en) 2014-01-23 2014-01-23 Compounds and compositions comprising carbon nanotubes and compounds of formula (I) and their use as contrast agents

Country Status (1)

Country Link
ES (1) ES2541787B1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019160419A1 (en) * 2018-02-16 2019-08-22 Universiteit Leiden Tripodal squaramide-based monomers
NL2020453B1 (en) * 2018-02-19 2019-08-27 Univ Leiden Tripodal squaramide-based monomers
CN113527167A (en) * 2020-04-14 2021-10-22 威智医药有限公司 Production method of vildagliptin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006051142A1 (en) * 2004-11-08 2006-05-18 Universidad Nacional De Educación A Distancia (U.N.E.D.) 1-pyrazolylethyl-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acids and application of the gadolinium (iii) complexes thereof in clinical diagnosis
US20130079503A1 (en) * 2011-09-08 2013-03-28 Research & Business Foundation Sungkyunkwan University Go-gd-dtpa complex, preparation method thereof, and mri contrast agent comprising the same
US20130231475A1 (en) * 2010-09-30 2013-09-05 Kyungpook National University Industry-Academic Cooperation Foundation Mri contrast agent having gadolinium complex

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006051142A1 (en) * 2004-11-08 2006-05-18 Universidad Nacional De Educación A Distancia (U.N.E.D.) 1-pyrazolylethyl-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acids and application of the gadolinium (iii) complexes thereof in clinical diagnosis
US20130231475A1 (en) * 2010-09-30 2013-09-05 Kyungpook National University Industry-Academic Cooperation Foundation Mri contrast agent having gadolinium complex
US20130079503A1 (en) * 2011-09-08 2013-03-28 Research & Business Foundation Sungkyunkwan University Go-gd-dtpa complex, preparation method thereof, and mri contrast agent comprising the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
M. F. FERREIRA et al., ¿Ln[DO3A-N-a-(pyrenebutanamido)propionate] complexes: Optimized relaxivity and NIR optical properties¿, Dalton Transactions, 2014 (accesible en linea 17-12-2013), vol. 43, páginas 3162-3173, ver Fig. 1 *
P. K. AVTI et al., ¿Toward single-walled carbon nanotube-gadolinium complex as advanced MRI contrast agents: Pharmacodynamics and global genomic response in small animals¿, Journal of Biomedical Materials Research Part B, 2013, vol. 101B, páginas 1039-1049 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019160419A1 (en) * 2018-02-16 2019-08-22 Universiteit Leiden Tripodal squaramide-based monomers
NL2020453B1 (en) * 2018-02-19 2019-08-27 Univ Leiden Tripodal squaramide-based monomers
CN113527167A (en) * 2020-04-14 2021-10-22 威智医药有限公司 Production method of vildagliptin

Also Published As

Publication number Publication date
ES2541787B1 (en) 2016-05-03

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