ES2529369B2 - Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia - Google Patents
Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia Download PDFInfo
- Publication number
- ES2529369B2 ES2529369B2 ES201300662A ES201300662A ES2529369B2 ES 2529369 B2 ES2529369 B2 ES 2529369B2 ES 201300662 A ES201300662 A ES 201300662A ES 201300662 A ES201300662 A ES 201300662A ES 2529369 B2 ES2529369 B2 ES 2529369B2
- Authority
- ES
- Spain
- Prior art keywords
- calcium
- dihydroxybenzenesulfonate
- achondroplasia
- dobesilate
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención describe la aplicación del 2,5-dihidroxibencenosulfonato de calcio (calcio dobesilato) para el tratamiento de la acondroplasia (enanismo). La aplicación del 2,5-dihidroxibencenosulfonato de calcio (calcio dobesilato) es capaz de reducir el nivel de fosforilación de las proteínas ERK1/2 que están anormalmente elevadas en la acondroplasia y causa los efectos característicos del enanismo. El efecto del 2,5-dihidroxibencenosulfonato de calcio (calcio dobesilato) reduciendo la fosforilación de ERK1/2 está relacionado con la disminución de los efectos patológicos asociados a esta enfermedad.The present invention describes the application of calcium 2,5-dihydroxybenzenesulfonate (calcium dobesilate) for the treatment of achondroplasia (dwarfism). The application of calcium 2,5-dihydroxybenzenesulfonate (calcium dobesilate) is able to reduce the level of phosphorylation of ERK1 / 2 proteins that are abnormally elevated in achondroplasia and cause the characteristic effects of dwarfism. The effect of calcium 2,5-dihydroxybenzenesulfonate (calcium dobesilate) reducing the phosphorylation of ERK1 / 2 is related to the decrease in the pathological effects associated with this disease.
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201300662A ES2529369B2 (en) | 2013-07-09 | 2013-07-09 | Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201300662A ES2529369B2 (en) | 2013-07-09 | 2013-07-09 | Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2529369A1 ES2529369A1 (en) | 2015-02-19 |
ES2529369B2 true ES2529369B2 (en) | 2015-10-14 |
Family
ID=52469462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201300662A Expired - Fee Related ES2529369B2 (en) | 2013-07-09 | 2013-07-09 | Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2529369B2 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0203172B8 (en) * | 2001-09-28 | 2021-05-25 | Nakao Kazuwa | pharmaceutical composition for achondroplasia |
ES2286933B1 (en) * | 2006-01-11 | 2009-10-02 | Fundacion Lopez Hidalgo | TREATMENT OF ACONDROPLASIA THROUGH THE ADMINISTRATION OF PIRIDOXAL AND ITS DERIVATIVES. |
US9198886B2 (en) * | 2006-08-16 | 2015-12-01 | Pedro Cuevas Sánchez | Use of 2,5-dihydroxybenzene for the treatment of ocular diseases |
ES2315117B1 (en) * | 2006-08-16 | 2009-12-30 | Action Medicines, S.L. | USE OF 2,5-DIHYDROXIBENCENIC DERIVATIVES IN THE PREPARATION OF USEFUL MEDICATIONS IN THE TREATMENT OF ASTHMA. |
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2013
- 2013-07-09 ES ES201300662A patent/ES2529369B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2529369A1 (en) | 2015-02-19 |
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