ES2525072B1 - Rodent model for fibromyalgia and chronic pain - Google Patents

Rodent model for fibromyalgia and chronic pain Download PDF

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Publication number
ES2525072B1
ES2525072B1 ES201300574A ES201300574A ES2525072B1 ES 2525072 B1 ES2525072 B1 ES 2525072B1 ES 201300574 A ES201300574 A ES 201300574A ES 201300574 A ES201300574 A ES 201300574A ES 2525072 B1 ES2525072 B1 ES 2525072B1
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ES
Spain
Prior art keywords
fibromyalgia
pain
rodent model
chronic pain
evaluation
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES201300574A
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Spanish (es)
Other versions
ES2525072A1 (en
Inventor
Mario David Cordero Morales
Manuel DE MIGUEL RODRÍGUEZ
Ángel Manuel CARRIÓN RODRÍGUEZ
José Antonio SÁNCHEZ ALCAZAR
Ángela FONTÁN LOZANO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Universidad Pablo de Olavide
Original Assignee
Universidad de Sevilla
Universidad Pablo de Olavide
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Publication date
Application filed by Universidad de Sevilla, Universidad Pablo de Olavide filed Critical Universidad de Sevilla
Priority to ES201300574A priority Critical patent/ES2525072B1/en
Publication of ES2525072A1 publication Critical patent/ES2525072A1/en
Application granted granted Critical
Publication of ES2525072B1 publication Critical patent/ES2525072B1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

El objeto de la presente invención se refiere a un modelo de roedor para fibromialgia y dolor crónico, inducido por tratamientos farmacológicos y nutricionales, así como la evaluación de la respuesta mediante pruebas de imagen cerebral. Se ha demostrado que mediante la inhibición parcial de los niveles de Coenzima Q en roedores, se reproducen los síntomas más comunes de la fibromialgia como son dolor, depresión, ansiedad, trastorno de la memoria y del sueño así como todas las alteraciones biológicas descritas en la enfermedad como inflamación, estrés oxidativo, déficit de serotonina. Por otro lado, así mismo se demuestra la sobreexpresión de un gen marcador del dolor, lo que nos aporta una herramienta molecular para la evaluación y control del dolor.The object of the present invention relates to a rodent model for fibromyalgia and chronic pain, induced by pharmacological and nutritional treatments, as well as the evaluation of the response by brain imaging tests. It has been shown that by partially inhibiting Coenzyme Q levels in rodents, the most common symptoms of fibromyalgia are reproduced, such as pain, depression, anxiety, memory and sleep disorders, as well as all the biological alterations described in the disease such as inflammation, oxidative stress, serotonin deficiency. On the other hand, the overexpression of a pain marker gene is also demonstrated, which gives us a molecular tool for pain evaluation and control.

Description



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Claims (1)



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ES201300574A 2013-06-14 2013-06-14 Rodent model for fibromyalgia and chronic pain Active ES2525072B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201300574A ES2525072B1 (en) 2013-06-14 2013-06-14 Rodent model for fibromyalgia and chronic pain

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201300574A ES2525072B1 (en) 2013-06-14 2013-06-14 Rodent model for fibromyalgia and chronic pain

Publications (2)

Publication Number Publication Date
ES2525072A1 ES2525072A1 (en) 2014-12-17
ES2525072B1 true ES2525072B1 (en) 2015-09-29

Family

ID=52016890

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201300574A Active ES2525072B1 (en) 2013-06-14 2013-06-14 Rodent model for fibromyalgia and chronic pain

Country Status (1)

Country Link
ES (1) ES2525072B1 (en)

Also Published As

Publication number Publication date
ES2525072A1 (en) 2014-12-17

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