ES2514165B1 - ANTI-FACTOR B ANTIBODY, PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF COMPLEMENT DISEASES AND THEIR APPLICATIONS - Google Patents
ANTI-FACTOR B ANTIBODY, PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF COMPLEMENT DISEASES AND THEIR APPLICATIONS Download PDFInfo
- Publication number
- ES2514165B1 ES2514165B1 ES201330452A ES201330452A ES2514165B1 ES 2514165 B1 ES2514165 B1 ES 2514165B1 ES 201330452 A ES201330452 A ES 201330452A ES 201330452 A ES201330452 A ES 201330452A ES 2514165 B1 ES2514165 B1 ES 2514165B1
- Authority
- ES
- Spain
- Prior art keywords
- antibody
- factor
- complement
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 230000000295 complement effect Effects 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 abstract 2
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 abstract 2
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 abstract 2
- 208000035913 Atypical hemolytic uremic syndrome Diseases 0.000 abstract 1
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 abstract 1
- 108010067641 Complement C3-C5 Convertases Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 230000024203 complement activation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002949 hemolytic effect Effects 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
Anticuerpo anti-factor B, composición farmacéutica útil para el tratamiento de enfermedades del complemento y sus aplicaciones.#La presente invención describe un anticuerpo anti-factor B que bloquea la generación de la convertasa del C3 de la vía alternativa útil para prevenir o modular la activación o amplificación de la activación del complemento. Una forma concreta de este anticuerpo es el anticuerpo monoclonal anti-factor B producido por el hibridoma FB-28.4.2 depositado en ACECC el 13 de noviembre de 2012 con la referencia 12111301. Además, proporciona una composición farmacéutica útil para el tratamiento de enfermedades asociadas del complemento como por ejemplo, el síndrome hemolítico urémico atípico (aHUS) o la hemoglobinuria paroxística nocturna (HPN). Igualmente, se proporciona un complejo biotecnológico útil para la realización de ensayos para la identificación y diseño de medicamentos o composiciones farmacéuticas inhibidoras del complemento.Anti-factor B antibody, pharmaceutical composition useful for the treatment of complement diseases and their applications. # The present invention describes an anti-factor B antibody that blocks the generation of C3 convertase from the alternative route useful for preventing or modulating the activation or amplification of complement activation. A specific form of this antibody is the anti-factor B monoclonal antibody produced by hybridoma FB-28.4.2 deposited at ACECC on November 13, 2012 with reference 12111301. In addition, it provides a pharmaceutical composition useful for the treatment of associated diseases. of the complement such as, for example, atypical uremic hemolytic syndrome (aHUS) or paroxysmal nocturnal hemoglobinuria (PNH). Likewise, a useful biotechnological complex is provided for carrying out tests for the identification and design of drugs or pharmaceutical compositions that inhibit complement.
Description
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201330452A ES2514165B1 (en) | 2013-03-27 | 2013-03-27 | ANTI-FACTOR B ANTIBODY, PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF COMPLEMENT DISEASES AND THEIR APPLICATIONS |
| PCT/ES2014/070236 WO2014154930A1 (en) | 2013-03-27 | 2014-03-27 | Anti-factor b antibody, pharmaceutical composition that can be used for the treatment of diseases of the complement system, and uses thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201330452A ES2514165B1 (en) | 2013-03-27 | 2013-03-27 | ANTI-FACTOR B ANTIBODY, PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF COMPLEMENT DISEASES AND THEIR APPLICATIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2514165A1 ES2514165A1 (en) | 2014-10-27 |
| ES2514165B1 true ES2514165B1 (en) | 2015-09-09 |
Family
ID=51622475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201330452A Withdrawn - After Issue ES2514165B1 (en) | 2013-03-27 | 2013-03-27 | ANTI-FACTOR B ANTIBODY, PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF COMPLEMENT DISEASES AND THEIR APPLICATIONS |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2514165B1 (en) |
| WO (1) | WO2014154930A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1007092T3 (en) * | 1997-08-26 | 2006-10-02 | Amgen Fremont Inc | A method for inhibiting complement activation via the alternative pathway |
| PT1054693E (en) * | 1998-02-20 | 2009-01-22 | Genentech Inc | Inhibitors of complement activation |
| ITMI20021527A1 (en) * | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | C5 COMPONENT ANTIBODIES OF COMPLEMENT AND THEIR USE |
| AU2005212369B2 (en) * | 2004-02-10 | 2011-06-23 | Musc Foundation For Research Development | Inhibition of factor B, the alternative complement pathway and methods related thereto |
-
2013
- 2013-03-27 ES ES201330452A patent/ES2514165B1/en not_active Withdrawn - After Issue
-
2014
- 2014-03-27 WO PCT/ES2014/070236 patent/WO2014154930A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014154930A1 (en) | 2014-10-02 |
| ES2514165A1 (en) | 2014-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2514165 Country of ref document: ES Kind code of ref document: B1 Effective date: 20150909 |
|
| FA2A | Application withdrawn |
Effective date: 20160210 |