Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Laboratories Inc
Original Assignee
Bristol Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Laboratories IncfiledCriticalBristol Laboratories Inc
Priority to ES0251309ApriorityCriticalpatent/ES251309A3/en
Publication of ES251309A3publicationCriticalpatent/ES251309A3/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A process for preparing tetracycline derivatives characterized by the fact that a compound whose formula is ** (See formula) ** in which TC represents the whole, except the carboxamide group of a tetracycline-type antibiotic, and B represents a primary or secondary amino group, is reacted with at least one equivalent of a hydrogen-replacing reagent, making a localized active hydrogen on a carbon atom in a phenolic ring, or on an oxygen atom, it is replaced to produce a substituted N '- (amino-primary or secondary-methyl) -tetracycline and, if desired, reducing the N' - ( amino-primary or secondary-methyl) -tetracycline substituted to produce an anulo-substituted tetracycline. (Machine-translation by Google Translate, not legally binding)
ES0251309A1959-08-061959-08-06A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding)
ExpiredES251309A3
(en)
Procedure for manufacturing and obtaining compounds and derivatives of benzotidyacine-1,1-dioxides (chlorotidates) (Machine-translation by Google Translate, not legally binding)
New procedure for the achievement of a cyanocobalamine association to organic calcium salts (Machine-translation by Google Translate, not legally binding)