ES2463366A1 - Método para la detección global de ganancias y/o pérdidas cromosómicas y array de búsqueda de alteraciones genéticas - Google Patents

Abstract

Método para la detección global de ganancias y/o pérdidas cromosómicas y array de búsqueda de alteraciones genéticas. La presente invención se refiere a un método in vitro de obtención de datos útiles para la detección y/o cuantificación de ganancias y/o pérdidas cromosómicas en un sujeto con una enfermedad genética. También se refiere a un método in vitro para el diagnóstico o pronóstico de una enfermedad genética o el diseño de tratamiento en un sujeto con una enfermedad genética caracterizado por comprender la detección de cambios en el número de copias de regiones cromosómicas concretas. Además, también se refiere a un array que comprende sondas que detectan cambios en el número de copias de dichas regiones cromosómicas y al uso del array para el diagnóstico o pronóstico de una enfermedad genética o el diseño de tratamiento en un sujeto con una enfermedad genética. También se refiere al uso de determinadas regiones cromosómicas como biomarcador para el mismo fin. La enfermedad genética es cáncer o una enfermedad congénita.

Description

La presente invención se refiere a un método in vitro para el diagnóstico o pronóstico de una enfermedad genética o el diseño de tratamiento en un sujeto con una enfermedad genética caracterizado por comprender la detección de cambios en el número de copias de regiones cromosómicas concretas. Por tanto, la invención se podría encuadrar en el campo del análisis genético.

ANTECEDENTES DE LA INVENCIÓN

La aparición de sistemas de análisis genómico masivo han permitido analizar en un sólo experimento el estado de miles de regiones a lo largo del genoma humano contribuyendo al conocimiento del componente genético de diversas patologías. La miniaturización de los sistemas de hibridación ha convertido a los arrays en una herramienta de alto rendimiento para el estudio de enfermedades congénitas y genéticas con afectación de uno o más cromosomas, con alteraciones de tamaños diversos, conteniendo la mayoría de ellas varias decenas, cientos o incluso miles de genes afectados que ponen de manifiesto la necesidad del uso de herramientas de estudio masivo (Fröhling S et al., 2008, N Engl J Med. 359(7):722-34). Los arrays identifican cambios en el número de copias a lo largo de todo el genoma tanto ganancias como pérdidas incluyendo deleciones homocigotas y amplificaciones génicas. El conocimiento de las alteraciones en el ácido desoxirribonucléico (ADN, cambios significativos, heterogéneos y recurrentes con posiciones concretas en las regiones cromosómicas implicadas) hace necesario su estudio al establecerse su valor diagnóstico y pronóstico, proporcionando factores objetivos para clasificar enfermedades así como para controlar e indicar tratamientos específicos, al descubrirse genes dianas y terapias específicas (Albertson DG et al., 2003, Hum Mol Genet. 12, 2:R145-52; Zhao X et al., 2004, Cancer Res. 64(9):3060-71). Entre los métodos para el análisis del genoma se encuentran la hibridación genómica comparada (CGH), la hibridación in situ (FISH), arrays con cromosomas artificiales de levadura (“Bacterial Artificial Chromosome” BAC arrays), técnicas basadas en la

reacción en cadena de la polimerasa (PCR) y el cariotipo. El conocimiento genético se ha fundamentado en los hallazgos de análisis citogenéticos convencionales y métodos moleculares, que son técnicas con limitaciones y ventajas, que pueden ser complementarias. El cariotipo tiene una baja resolución, es necesario realizar previamente cultivos celulares que alarga el tiempo de diagnóstico, selecciona clones con ventaja proliferativa, analiza un bajo número de células y existe subjetividad en la interpretación pero permite el estudio global del genoma. La CGH convencional informa del contenido del ADN de varios miles o millones de células pero presenta inespecificidad en la hibridación por el tamaño de las sondas. La FISH es muy específica, se puede realizar en interfase y/o metafase pero es parcial, dirigida a zonas del genoma y limitada generalmente a tres fluorocromos y sus combinaciones. Por otra parte, la PCR es económica pero parcial y dirigida a regiones concretas en cada análisis. El uso de arrays resuelve algunas de estas limitaciones al proporcionar mayor resolución, mayor número de regiones en cada estudio y objetividad en el análisis genético.

Existen diversos arrays para estudiar globalmente el genoma que comprenden miles de sondas y la tendencia es aumentar las sondas contenidas en los mismos. Así de arrays que contenían 77 sondas subteloméricas para identificación de retraso mental, se pasó a arrays de expresión con 20.000 a 50.000 sondas y/o arrays que detectan polimorfismos con medio millón ó 1.800.000 sondas. Análisis comparativos de estas plataformas muestran la sensibilidad y especificidad de los distintos arrays (Fadista J et al., 2012, PLoSOne. 7,2:e31025). Los arrays comerciales disponibles en la actualidad tienen en común el elevado número de secuencias pero características diferentes como son: el método de producción, distintos tamaños en las secuencias inmovilizadas (entre 25-80 nucleótidos) y el tipo de marcaje para la hibridación (único

o doble). La fabricación estandarizada de estos arrays ha ido completando y mejorando formatos sucesivos y se han diseñado con fines diferentes: estudio de variaciones génicas, análisis preimplatación de embriones, microdeleciones, genotipado, estudio de neoplasias hematológicas, análisis de genes supresores y oncogenes y análisis de metilación (Curtis C et al., 2009, BMC Genomics. 10:588-610; Miller DT et al., 2010, Am J HumGenet. 286(5):749-64; Crespo I et al., 2011, J Mol Diagn.13(6):634-47 y Tabernero MD et al, 2012, Genes Chromosomes Cancer. 2012,51(6):606-17).

El alto número de sondas inmovilizadas en los distintos arrays diseñados hace imprescindible el uso de herramientas informáticas para obtener la gran cantidad de información contenida. Los análisis matemáticos identifican las variaciones en toda la extensión del genoma, y la dependencia de recursos bioinformáticos tienen un impacto no despreciable en la incorporación al diagnóstico clínico de esta tecnología. Actualmente, los arrays contienen millones de sondas de oligonucleótidos con un importante coste de fabricación y de recursos en el análisis de la información que contienen, pero no existe un array simple y específico para analizar en muestras de ADN el número de copias de los 24 cromosomas en toda su extensión con utilidad en cáncer, enfermedades genéticas y/o hereditarias u otras patologías. Por lo tanto es necesario un array de menor tamaño que los actuales, que siga siendo informativo para detectar el número de copias de todos los cromosomas y las regiones de interés en enfermedades genéticas.

DESCRIPCIÓN DE LA INVENCIÓN

La presente invención se refiere a un método in vitro para el diagnóstico o pronóstico de una enfermedad genética o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética mediante la detección de cambio en el número de copias de regiones cromosómicas concretas que proporcionan información sobre todos los cromosomas. La invención también se refiere a un array de búsqueda de alteraciones útil como herramienta diagnóstica y/o pronostica de alteraciones genéticas y para la individualización de tratamiento en pacientes que proporciona información sobre todos los cromosomas. El método de la invención y el uso del array de la invención también permiten orientar los siguientes pasos diagnósticos con otras técnicas complementarias según la muestra analizada para ser una alternativa a las herramientas existentes de diagnóstico convencional y evaluar la muestra con otros métodos complementarios. El método de la presente invención y el array de la invención permiten, hibridando con secuencias distribuidas en los 24 cromosomas, identificar las alteraciones del número de copias de regiones cromosómicas y obtener información de estado de genes importantes en enfermedades genéticas de manera más sencilla que los métodos actuales manteniendo la especificidad.

Un primer aspecto de la invención se refiere a un método in vitro de obtención de datos útiles para la detección y/o cuantificación de al menos una ganancia y/o pérdida cromosómica en una muestra aislada de un sujeto con una enfermedad genética, donde la detección se realiza en las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23, 1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25, 3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11, 6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14, 11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11, 16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11. En adelante nos referiremos a las regiones cromosómicas aquí descritas como a las “regiones cromosómicas de la invención”.

Un segundo aspecto de la invención se refiere a un método in vitro para el diagnóstico

o pronóstico de una enfermedad genética o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética caracterizado por comprender los siguientes pasos: (a) detectar y/o cuantificar al menos una ganancia

y/o pérdida cromosómica en las regiones cromosómicas de la invención en una muestra aislada de un sujeto; (b) comparar el número de copias de las regiones cromosómicas detectadas y/o cuantificadas en el paso (a) con niveles estándar; (c) encontrar al menos una diferencia significativa en la comparación del paso (b); (d) asociar la diferencia significativa del paso (c) a una ganancia o a una pérdida genética; y (e) asociar las ganancias o pérdidas genéticas del paso (d) a una enfermedad genética.

Un tercer aspecto de la invención se refiere al uso in vitro del número de copias de las regiones cromosómicas de la invención como marcador diagnóstico o pronóstico de enfermedades genéticas o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética.

Un cuarto aspecto de la invención se refiere a un array que comprende sondas que detectan ganancias y/o pérdidas de las regiones cromosómicas de la invención donde el número de dichas sondas se sitúa entre 10.000 y 20.000 sondas.

Un quinto aspecto de la invención se refiere al uso del array del cuarto aspecto de la invención para el diagnóstico o pronóstico de enfermedades genéticas o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética.

DESCRIPCIÓN DETALLADA DE LA INVENCIÓN

La presente invención proporciona un método in vitro de diagnóstico y/o pronóstico de alteraciones cromosómicas que comprende la detección de: pérdidas o ganancias de un cromosoma completo, pérdidas o ganancias parciales, regiones de amplificación génica, regiones de deleción homozigota o de detección de polimorfismos en todos los cromosomas de un individuo.

Por tanto, en un primer aspecto, la presente invención se refiere a un método in vitro de obtención de datos útiles para la detección y/o cuantificación de al menos una ganancia y/o pérdida cromosómica en una muestra aislada de un sujeto con una enfermedad genética, donde la detección se realiza en las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23,

1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25, 3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12,, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11, 6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14, 11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11, 16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11. En adelante nos referiremos a este método como al “método primero de la invención”. Tal y como se ha explicado anteriormente, las regiones cromosómicas (loci) aquí descritas se denominan en la presente invención “regiones cromosómicas de la invención”.

Una realización preferida del primer aspecto de la invención se refiere al método donde la enfermedad genética es cáncer o una enfermedad congénita.

El término cáncer (o tumor) se refiere en la presente invención a la enfermedad que se asocia a la presencia de células que poseen características de células tumorales conocidas por el experto en la materia, como son la proliferación sin control, inmortalidad, inducción de angiogénesis, resistencia a la muerte celular programada y

potencial metastásico (Hanahan D et al. 2011 Cell 144(5):646-74). En la presente invención el término “cáncer” incluye tumores primarios (con células del mismo origen del lugar donde se encuentran) o metastásicos (con células de distinto origen del lugar en el que se encuentran) y también incluye los tumores en cualquiera de sus grados de afectación o estadio.

Una realización aún más preferida del primer aspecto de la invención se refiere al método donde el cáncer es cáncer del sistema nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemias linfáticas crónicas, leucemias linfáticas agudas, mieloma múltiple, síndrome mielodisplásico (por ejemplo, anemia refractaria y síndrome mielodisplasico con deleción 5q). Preferentemente, el cáncer del sistema nervioso central es glioma (bajo y alto grado), meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme. En la presente invención el término “glioma” incluye tumores de bajo y alto grado.

Se entiende como enfermedad congénita aquella enfermedad que se manifiesta desde el nacimiento, ya sea producida por un trastorno durante el desarrollo embrionario o como consecuencia de un defecto hereditario. Preferentemente la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.

El término “in vitro” se refiere a que el método de la invención se realiza fuera del cuerpo del sujeto.

El término “sujeto” se refiere a un individuo, preferentemente humano, que puede presentar una alteración genética y puede haber sido o no diagnosticado de una enfermedad genética. En la presente invención los términos “sujeto” “individuo” y “paciente” se utilizan indistintamente.

En la presente invención se entiende por “ganancia cromosómica” el aumento en el número de copias de material genético en una región cromosómica comparado con un control. Por “pérdida cromosómica” se entiende la disminución del número de copias de una región cromosómica comparada con un control. En la presente invención se entiende como “alteración génica” o “alteración genética” tanto una ganancia como

una pérdida genética. Como “control” se entiende una muestra de un individuo que no presenta alteración genética.

El término “muestra” se refiere a una “muestra biológica” y se refiere a cualquier muestra que permita obtener ADN del individuo del que se ha obtenido dicha muestra, e incluye, pero sin limitarnos, tejidos y/o fluidos biológicos de un individuo, obtenidos mediante cualquier método conocido por un experto en la materia que sirva para tal fin. La muestra biológica podría ser, por ejemplo, pero sin limitarse, un tejido o una muestra de fluido, como sangre, plasma, suero, mucosa oral, lavado broncoalveolar, linfa, fluido ascítico, líquido pleural u orina. Asimismo, la muestra biológica puede ser, por ejemplo, pero sin limitarse, fresca, congelada, fijada o fijada y embebida en parafina.

De una muestra biológica se extrae el material genético mediante cualquier método conocido por el experto en la materia. En la presente invención como material genético se entiende ADN.

Las “regiones cromosómicas de la invención” son regiones que se sitúan en los cromosomas 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, X

o Y, en el brazo corto (p) o en el brazo largo (q) del cromosoma.

Se entiende por enfermedad “genética” aquella que está asociada a una alteración en el material genético presente en un sujeto.

Un segundo aspecto de la invención se refiere a un método in vitro para el diagnóstico

o pronóstico de una enfermedad genética o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética caracterizado por comprender los siguientes pasos: (a). detectar y/o cuantificar al menos una ganancia y/o pérdida cromosómica en las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23, 1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25,

3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11, 6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14, 11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11, 16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11 en una muestra aislada de un sujeto; (b) comparar el número de copias de las regiones cromosómicas detectadas y/o cuantificadas en el paso (a) con niveles estándar; (c) encontrar al menos una diferencia significativa en la comparación del paso (b); (d) asociar las diferencias significativas del paso (c) a una ganancia o a una pérdida genética; y (e) asociar las ganancias o pérdidas genéticas del paso (d) a una enfermedad genética. En adelante nos referiremos a éste como al “segundo método de la invención”.

El término “diagnóstico” en la presente invención se refiere a la capacidad de detectar una enfermedad genética en un sujeto.

El término “pronóstico” en la presente invención se refiere a la capacidad de detectar una alta o baja probabilidad de desarrollar una enfermedad genética aún cuando en el momento del diagnóstico no presenten dicha patología. También se refiere a la capacidad de predecir la evolución de un paciente con una determinada enfermedad (también denominada patología).

Se entiende por “tratamiento” al conjunto de medios que se emplean para curar o aliviar una enfermedad.

Con “diseño de un tratamiento personalizado” se entiende la determinación de la necesidad de un individuo de recibir un determinado tratamiento en base a la detección de una ganancia y/o pérdida cromosómica en las regiones cromosómicas de la invención, es decir, con el método de la invención se clasifica al individuo en un grupo de individuos con necesidad de tratamiento específico para una determinada enfermedad o en un grupo de individuos que no presentan necesidad de tratamiento específico para la misma.

Se entiende por niveles “estándar” aquellos que provienen de una muestra control que no contiene alteración genética en la región cromosómica a comparar.

Una realización preferida del segundo aspecto de la invención se refiere al método donde en el paso (d) y el paso (e) la ganancia o pérdida genética es una pérdida o ganancia de al menos un cromosoma entero, de al menos uno de los brazos de un cromosoma o de al menos una región cromosómica de al menos uno de los brazos de un cromosoma.

Otra realización más preferida se refiere al método del segundo aspecto de la invención donde la detección y/o cuantificación del paso (a) se realiza mediante la detección y/o cuantificación de al menos un gen que se encuentre localizado en las regiones cromosómicas descritas en el paso (a).

Una realización aún más preferida del segundo aspecto de la invención se refiere al método donde los genes son los genes de la tabla 1. En adelante nos referiremos a ellos como a los “genes de la invención”. Los genes de la invención se encuentran localizados en las regiones cromosómicas de la invención.

Tabla 1. Genes localizados en las regiones cromosómicas de la invención: se proporciona el número de identificación de los 3920 genes “Entrez Gene ID” del “National Center for Biotechnology Information (NCBI)” Bethesda, Maryland, USA.

Cromosoma 1:

10905;4853;200162;6913;10352;79679;829;55917;9860;260425;26191;54665;10390;1 28338;2773;57535;56900;10451;22911;1301;94236;118427;8556;51611;148867;5825; 199857;1806;440594;729970;58155;126969;148534;9411;676;284697;388649;1810;2 53152;54874;100131564;79871;56267;2633;2634;2635;163351;2959;23507;84230;55 86;84146;9403;9653;339524;51100;26289;64123;54810;23266;57554;257194;91624;5 567;5733;148418;204962;81849;79739;26009;55635;6121;29929;27329;400757;8544 0;3716;57708;55225;4919;84251;23169;148581;79819;127795;51361;1600;284546;10 31;55268;2060;11124;348378;148979;388633;7804;4898;5865;6342;6512;55706;5106 0;23358;54432;23318;9372;84871;79656;51727;284541;1580;199974;388630;54558;8 891;79033;23139;8503;5052;55182;6487;10420;57643;728621;991;114625;440585;22 887;59269;9132;64175;4802;6018;22955;6513;64744;149465;4904;10269;84970;1441 ;114784;192669;284656;29889;2899;79932;23499;64769;54933;64121;6421;83931;27 285;9967;9202;5928;127544;64766;8565;7579;1307;149086;8073;347735;9410;51538 ;2035;10076;6429;27245;79000;90529;57035;2134;2268;3155;3151;26119;57134;127 294;6006;6007;57190;6548;23585;23038;249;1870;8672;2048;50809;3339;23028;401 944;7798;6920;84196;80818;22977;8659;440574;832;284729;54455;84966;23065;468 1;29943;11240;5081;55920;6390;23013;255104;23352;7709;79814;780789;842;23341 ;114827;23254;126755;10630;65121;390999;400735;440561;7799;378708;100526739 ;148345;284498;54897;1185;56998;5394;26270;9563;23095;10747;9927;2475;64802; 5195;5226;5293;57540;80176;10277;55187;23261;54206;11315;473;11332;26038;557 35;83715;8514;9903;261734;57449;27237;148870;1677;57212;9731;1953;79258;7990 6;55229;63976;127262;2782;85452;100129534;5590;6339;51150;6497;9906;29101;25 4173;2330;8515;128077;9659;5174;27246;9554;647135;10628;51205;607;2702;2703; 440689;54460;56957;51177;11311;405;149428;57530;2029;80308;2312;388698;5745 9;55204;84072;3782;353135;353144;84648;114771;57115;23126;9129;58497;5692;60 97;23248;6282;6278;8991;10500;4184;81609;80222;11022;117145;7286;10485;14909 5;57657;128239;57127;83416;4914;9047;477;1314;50717;23385;26476;114836;22926 ;4009;9722;387597;400794;4259;55732;92342;22920;6401;26052;9910;27;84320;460; 126859;55103;9462;6646;163589;163590;3918;23057;23179;85397;9213;3080;16348 6;140609;51094;134;493;5129;1118;6900;1465;2005;9641;10765;9928;23046;55220;9 3273;148808;89796;23114;2494;64710;8497;4660;254428;9580;23380;127833;92703; 653659;252839;57172;1604;3756;3914;642587;255928;467;51514;28982;4751;5525;2 6750;7188;10380;2058;2104;55699;3776;25782;51018;7042;7399;127602;3707;142;5

6997;8476;2590;79605;5664;128061;54583;440730;128178;56605;7107;359948;9859; 64388;55127;3964;100130331;23596;6000;6262;10806;128025;10000;163882;339529 ;284521;64754;79894.

Cromosoma 2:

645784;200523;129293;1768;9451;7844;22934;150572;51652;6936;1496;3099;80059; 9801;72;1639;6242;10505;200424;10574;23233;26056;94097;27332;22848;200558;99 38;400961;5341;10097;23177;25927;400958;200734;130872;84542;7360;9736;11480 0;400954;400957;400955;64895;150962;98;51130;27248;100302652;23198;6711;937 8;27436;63892;130589;92906;6546;5610;54497;6801;5212;57448;84661;51072;55622 ;84272;238;92291;79623;81606;253558;6716;7498;9577;388939;79745;165186;2355; 9553;5500;245711;23160;54454;10669;1838;3032;9381;9784;84450;338;114818;4148 ;130502;57539;348654;3790;729475;79677;7447;23175;150622;52;285016;339822;26 751;7173;7260;51112;26504;51252;23397;23020;23505;2274;3554;80146;165055;109 13;3987;5903;344558;151011;55289;4867;11159;10096;54520;8886;57628;80255;273 6;274;29798;440915;2863;4249;344148;1615;4175;81615;53353;339745;55843;8942; 26122;3800;130576;55777;5000;130574;27249;114805;90134;10213;85461;10010;80 034;6326;129446;1386;1123;1781;254042;79828;140469;8604;285025;4780;91404;15 1126;151242;10203;142679;165215;2487;3685;10787;129401;5136;116093;51454;53 78;6775;84128;57520;9262;57679;151254;65062;316;843;841;130535;58538;60491;5 334;151246;26010;8745;391475;130752;117583;389072;389073;2066;4133;200576;5 746;79582;26154;729582;55686;55825;92691;7520;2181;130340;10056;116255;5077; 5270;130367;57590;55619;79843;92737;80309;9320;80210;389084;129563;80303;26 058;55355;3769;4691;25791;5147;5707;3431;93349;79054;54575;54576;116987;2367 7;23192;1293;728294;339768;9855;64090;9759;84289;728323;9208;23178;51540;259 92;51078;140739.

Cromosoma 3:

874253559;2632;6091;6092;27086;26018;9223;166336;115286;8618;2272;5793;1322 04;26059;54899;7474;440957;776;55799;25981;55193;1795;51409;7867;80335;72923 0;1232;79443;23395;79442;4134;10180;22908;55129;152206;440952;131375;4336;25 924;4820;22906;7433;11280;23122;10491;10015;7342;114884;201595;339896;15211 0;9497;7048;55768;5915;7068;7324;6304;51244;84077;23473;344875;8292;152273;8 0852;64432;7182;9467;6533;79188;348825;7476;64145;132001;6854;80746;10533;49 1;56852;9901;25917;2917;3708;285362;152330;3568;10752;27255;1371;285220;2550 25;10402;25890;55773;55076;91775;50939;131368;56987;25945;523;91653;79669;10

225;90102;1814;54762;4045;26137;152404;2960;9515;84925;79663;4638;54625;1095 4;54437;57493;3693;8997;114885;84561;7707;10840;348807;55764;54946;644974;84 19;131034;23317;729375;348808;79858;58477;23023;66000;11073;2047;51163;1992 21;83850;22808;347736;64084;55186;92369;253461;205428;5352;285195;116933;11 6931;26084;170506;344758;8833;7881;23007;79674;51319;654502;100505385;15174 2;29970;165679;647107;151790;79740;2122;254827;57552;83893;10242;10057;8893; 54800;89857;55486;7066;55689;1608;1962;23355;51726;3273;3827;253573;5648;648 0;55171;152137;9076;3556;55214;4026;8626;285386;84239;344905;152002;1739;842 48;84223;89782;348840;84859;55341;4976;5062;5504;205564;7037.

Cromosoma 4:

1259;10699;2557;2560;152518;152519;7006;7294;323;389207;386617;22998;116984; 55584;401124;54502;57728;5099;886;80333;55300;3516;51091;55296;683;114905;57 545;645104;84448;60312;84740;116449;152789;5522;54436;56606;57533;9948;3891 97;132884;55351;118;317648;1487;8603;2868;3064;8602;10336;353497;6047;6452;1 0417;10460;100379220;84286;7468;57732;7700;152687;255403;170960;654254;6422 80;132946;9575;23142;55763;81608;57482;3815;84708;644145;132954;5471;5978;15 2579;6443;132671;6731;55858;64854;2044;23284;26228;9407;28983;55236;10941;57 4537;91746;9508;27284;6783;419;3627;25898;55153;57619;84779;153020;84803;834 78;10855;4299;5602;5783;9429;345275;57563;6622;8404;2895;658;285555;10611;56 916;8633;124;125;126;127;128;130;131;84103;27071;79982;1977;8649;23173;4547;5 910;93587;10098;6870;84570;9348;11107;2247;11162;166378;80167;132321;55132;2 56471;10424;79960;10733;132320;25819;1047;1998;255520;100129858;55534;4258; 80155;60592;80854;7350;64399;3600;8821;57484;11157;84068;83894;152485;79658; 166614;4306;90826;55751;54798;55294;2244;152503;51802;2982;6999;55016;55319; 56884;92345;11199;55601;1182;4750;57630;442117;140458;2823;116966;285501;55 247;133121;3660;79682;8470;2195;2483;285441;4543.

Cromosoma 5:

2255;2690;348980;1601;133690;3575;92255;6507;79925;133688;167127;29102;4883; 23037;1008;1007;56979;1010;54463;4651;1767;7204;170690;23379;340094;57491;13 3957;81037;11336;728613;79888;85409;10016;153478;10723;348932;6531;7015;798 44;3001;3672;3673;5144;91942;375449;55814;153562;64087;64283;64924;8507;2604 9;22987;55255;8546;29958;10184;23440;9522;6902;83734;153339;1462;7518;10085; 84059;10622;153396;831;22936;51752;64167;2745;167410;79772;5122;22836;5066;7 903;83594;1946;4124;9315;814;91137;642987;134430;324;64097;4163;64848;5229;1

176;206338;51397;57556;153443;153241;93166;28966;171019;337876;2201;644873; 6558;28965;27125;645121;9547;10111;153328;4090;7045;57113;64374;23092;57528; 80762;2908;815;22993;3360;5145;133522;5521;6534;84651;643394;202374;2196;206 358;153201;11346;10827;55568;2890;8728;147;26999;1879;84868;6444;7265;57451; 5917;662;1794;100131897;8614;92181;10814;253314;23197;3274;57179;285593;643 24;94081;90249;23567;79908;153579;57472;91522;2324;9945;5601;55819.

Cromosoma 6:

5558;653;81578;26268;8521;22858;4172;5314;221395;10231;7021;89845;705;896;98 8;53405;22875;55168;5429;221409;8464;129685;441151;55362;55809;57510;24149;1 14781;646888;2739;221458;266727;221468;60685;64771;2914;11165;29993;8831;79 17;135656;170679;7148;387032;7718;7741;6568;6310;84062;9750;401237;9308;5443 8;23408;84830;1906;3096;221692;51256;54898;2651;4739;51522;100113407;654;183 2;9521;63915;266553;6239;7020;2162;9450;285780;154386;4835;63027;56897;56940 ;55770;642316;577;346007;56479;22999;90025;51167;22832;4199;112609;167681;98 92;1081;9096;23036;57150;206412;2570;84553;51805;84539;85015;10973;2898;5753 1;202;221264;84071;11149;9896;112495;100422737;57107;84816;11231;2444;22255 3;154215;10345;135112;60487;3908;84870;2037;84456;285733;154075;6446;10767;4 217;100131814;167838;3097;9749;8676;7402;389432;9590;2099;25902;57480;23345; 10090;340152;26271;54516;4988;26575;57492;729515;84624;50508;6580;51429;887 1;117289;51106;26230;56995;79683;56895;4216;5071;55780;84498;10846;5689;6196 ;64094;253769.

Cromosoma 7:

346288;1956;2631;55915;81552;222008;349075;23242;1644;2887;100130988;375567 ;11055;154664;136288;80099;3364;168507;256979;64759;54606;23072;4967;5478;83 637;9844;2737;5683;23333;23080;27241;168667;222166;100129460;79017;10392;38 7129;51251;5137;84725;9805;9586;221895;8701;9771;9734;7291;1607;2115;4223;34 0267;3382;221981;221806;221937;9907;55698;401303;84433;2768;221935;155185;9 0639;26173;23288;100128374;8379;64940;7697;340252;442319;26053;83698;64409; 9031;57639;2006;3092;54103;5782;222194;781;9863;57157;53616;54677;55972;5218 ;219578;55971;799;55610;285987;1780;2792;5445;5446;55607;7979;10165;1523;136 227;222234;222235;402569;222236;5701;5649;375612;55973;10135;5172;1738;9398 6;83943;29969;4897;5506;1811;830;1080;4233;7982;93654;22797;7472;83992;51691; 93664;6561;50833;2918;3952;55131;93979;4899;114960;7328;54927;378805;136259; 5420;1129;64764;9162;5764;346673;50617;27147;84255;8805;254048;56829;26047;1

00302191;27010;11194;10061;653857;2636;155038;285972;51422;1804;285888;5748 8;64327;389602;54892;64434;5799;140545;9690;7434;55112.

Cromosoma 8:

286;10947;7994;5423;7419;8749;2515;2260;203100;6867;157855;84750;23303;3084; 11030;1191;51435;286133;10863;51312;55909;9583;4017;4023;10395;23362;137868; 1508;1671;340357;91694;64478;157695;9228;157697;26260;9172;644128;23514;559 1;137902;389658;115294;9821;9705;6917;9760;55636;286183;10987;85479;9650;515 0;10565;116328;57094;1360;80243;100132891;392232;10499;63978;8989;83690;100 192378;79776;51101;3574;759;138046;245972;4325;85481;11059;157657;286148;10 0500773;642924;10404;6788;157680;1807;8323;29967;9699;55074;23414;27012;114 788;8667;2131;169026;401474;4982;9897;286053;93594;22882;50807;51571;114;378 6;51105;6482;169044;575;389690;51305;54742;5747;203062;58500;7553.

Cromosoma 9:

441430;441425;253650;647044;79937;9380;9833;5079;64425;152006;138724;971;25 853;27019;4799;5646;8434;9853;27290;51271;55833;54926;10497;7415;54840;2683; 3301;158038;4712;80173;79817;7010;286319;1029;100048912;54914;554202;4300;4 507;401494;340485;92949;55667;158297;123;25769;54796;54875;6456;100129385;2 03238;158326;389705;4781;11168;6619;158219;340481;8777;5789;7306;55848;5506 4;2731;90865;23081;2315;115426;169792;5991;6505;1761;58524;81704;23189;6595; 320;9413;2395;5239;8395;9414;138255;256691;375743;80036;301;100302287;5125;1 17531;9630;158471;29968;23230;7091;257019;158158;389766;392360;392364;4915; 10927;340515;6850;138649;23299;445577;401541;4920;65268;375748;84909;2176;2 2927;5727;100499483;8555;1306;7464;100499484;57653;4686;9830;19;23446;10592; 11217;652972;23731;158401;8727;54566;8518;23392;1902;100422990;114299;44581 5;22949;5774;64420;7357;158399;80709;85301;25861;114991;23245;1620;10012850 5;5069;727;55755;11064;5082;51552;23637;7185;57706;89853;2649;5695;9649;1759; 23048;57720;28989;114789;25;83543;23404;10319;59335;84726;389799;64794;8328; 9329;9442;84628;8021;2889;23064;7248;11094;1757;774;157922;79813;57582;9919; 643224.

Cromosoma 10:

94134;3799;6935;387647;1326;6840;10006;2572;57512;56243;84930;53904;23590;56 952;5305;100169750;340895;64215;10529;84898;783;9200;221074;338596;8027;571 18;83643;55691;10133;1787;10659;22944;57713;83860;83592;2665;1316;10276;105; 55853;22982;23185;642394;22884;10771;9790;414194;283033;441666;8187;7582;10

0129482;93550;118738;56624;282966;196740;1103;8031;55753;8505;57705;65217;5 592;288;983;9886;22891;29119;26091;221037;84665;23411;84883;219738;1305;5550 6;5464;8879;23555;83938;23522;100288974;650623;8512;219654;57178;92211;8433 2;27069;2894;4143;10718;387694;81619;657;9060;23063;118932;84896;142913;9023 ;9585;3988;643414;643418;5728;55328;54708;9044;22849;100188947;84333;80351;5 5165;1562;1559;118924;338557;26509;64318;51196;29760;100127889;9124;5223;10 580;9849;27291;55118;3257;60495;10613;55719;5076;9033;25956;8945;54805;22978 ;79991;9644;9748;120;80217;159686;22986;7511;282996;26033;2674;255082;196047 ;118987;6001;196051;55717;26098;64077;100169752;7390;8038;4288;5791;1571;253 738;3632;282973;619207;4255;93426;256536.

Cromosoma 11:

441601;221120;60529;9793;1408;2132;2147;51317;56981;55761;51074;341019;4400 34;26298;2001;8050;744;63982;338645;89797;4745;340990;5286;144100;10196;5555 3;55293;10083;84280;797;1315;22800;10418;7003;374378;9645;10335;322;417;5667 2;10527;3784;4004;283104;283299;650368;56547;4676;4928;114879;27315;50862;81 846;6764;6786;23075;143425;338440;51272;81532;6150;171389;113746;6181;1500;9 2292;283194;9404;219527;504189;219956;6947;51338;643680;7439;11145;387775;4 296;23649;5526;7536;55867;4041;55690;51111;1374;8500;116985;9828;408;26005;8 1570;9873;81544;387273;220074;4926;283208;5138;283209;10714;51400;254225;22 941;9789;55331;28971;1740;92105;65987;79731;26011;2915;4544;7299;84441;14387 2;53942;5241;330;4322;64066;4314;4316;60496;834;2893;84437;120400;4684;7704;2 900;25988;10525;100499227;9099;399959;6653;50937;79607;84623;84881;8538;231 3;29068;112937;22997;83700;50863;4978.

Cromosoma 12:

160518;121512;55297;341350;83857;56938;341346;23012;586;55259;55500;2998;98 47;3845;5965;6579;10599;6660;8082;6489;5139;28234;5288;2842;2904;8531;2120;11 8426;50840;2;359787;51348;10219;4074;8076;360030;9918;5858;57494;440077;5710 2;2251;26290;3742;10867;79602;283358;775;93589;196513;23085;144699;440073;57 4538;7004;7289;65125;80070;144402;120892;283463;4753;29951;51535;144165;114 134;84216;54934;8909;91523;3906;29843;7421;466;121006;91010;613227;113251;91 012;25875;51474;255411;25840;27289;65244;7009;283471;401720;9119;283404;546 3;6334;7024;9840;3798;4035;4141;5557;5939;65012;6773;116986;10677;1594;33881 1;121227;10956;9958;115749;57460;29110;11260;400046;23426;8091;23592;253827; 144453;10576;1368;10818;27345;56890;5787;5801;117177;8549;83591;29953;7103;1

96441;89795;6857;8499;144448;80184;8411;55591;144193;56899;374467;120935;40 48;4604;27340;121551;50515;83468;253724;4801;51559;6996;160762;23316;160760; 51699;80724;6311;8550;283450;8437;22895;80024;10906;23389;23014;26259;28345 5;4842;160777;11113;84530;51347;55884;140707;9478;10645;84660;80212;6249;196 385;8655;338442;27198;2967;9735;5027;353116;9921;65117;55206;949;121665;1444 06;55596;100128554;387895;92293;2802;6433;2054;121256;7556;7699;10795.

Cromosoma 13:

51084;8100;53342;26524;100101938;221143;266695;93492;64328;6445;221178;5550 4;1024;10810;255967;51082;145173;3146;10808;84056;51371;5412;116828;9365;104 43;23047;90627;5983;400120;9201;100302239;26960;161003;7223;11215;29103;550 68;94240;2963;26747;23143;10161;5925;81550;79866;11278;10464;4008;1910;64062 ;26050;2262;10082;10257;9071;5911;10160;8428;171425;5095;84899;9358;728215;2 3026;8874;23250;8881;8451;55208;79774;23263.

Cromosoma 14:

1603;23428;9472;25831;80224;29966;55837;64067;58533;11177;84312;9692;55012;2 53959;89874;145282;57697;122773;23588;161357;122769;9147;145447;30001;10979 ;122786;54331;11183;22795;51199;5706;5836;6815;114088;652;23034;22863;3895;3 87332;317761;5583;51804;646113;27133;6617;23224;83851;2342;2530;4149;87;8816 ;55218;57452;9766;5890;161145;8650;9628;64093;53349;55668;2103;399671;122953 ;9870;85457;9369;9517;57156;161436;23768;1112;54207;55812;123016;79882;90141 ;80017;801;440193;8111;55775;55727;79820;3705;57578;123036;79789;23405;25639 4;866;2009;100129345;283600;7443;1778;23186;9895;4140;7187;122622;113146;233 68;388021;100128927.

Cromosoma 15:

23742;23191;727924;8123;6638;8926;7337;2558;2562;2567;100128714;321;23359;89 24;4948;89839;22909;100288637;1139;342184;51621;161725;9716;89978;57099;845 29;1133;161835;4212;6263;9990;7057;11261;161829;729073;11245;3712;56924;8773 ;9333;116179;80021;146057;197131;113201;51496;84978;9836;7158;2200;2585;2625 8;9728;80031;399694;79029;58472;23431;79895;196951;56986;4644;29766;388121;3 66;9236;84952;161582;145781;3990;4734;283659;5873;6938;440279;256764;54629;5 4778;79811;4643;6095;83660;53944;84465;79719;4088;10391;22801;5607;10031388 4;4649;79400;8554;79875;80381;4016;5371;1464;26263;730058;145957;192683;4985 5;2184;3419;283688;646892;400410;23102;54469;57188;8120;79631;283726;648809; 6457;388165;123624;11214;57538;5151;11057;176;290;1106;55215;100144604;5428;

56963;28232;8128;56964;374655;145820;400456;91947;22856;3480;204219;55180;7 9705;5046;123283.

Cromosoma 16:

112869;3683;23214;9726;55114;146395;115584;27327;730094;91949;84516;23062;9 956;5347;5579;57478;146177;116285;123876;6296;57020;400506;9738;55567;11247 9;124274;51704;124152;81691;64131;4363;89927;23042;55313;2072;729993;23274;9 2017;2903;8312;254528;146439;23059;84256;114984;9742;83986;54442;64788;1001 28770;55692;64386;79903;4716;197358;9091;9088;9727;54715;9351;23524;79652;10 131;7752;146434;124149;10294;84706;91807;79801;55737;113;123970;1540;81533;8 1831;85407;5257;27324;23090;390732;80205;79068;283856;54947;4313;5934;23322; 1071;4489;4496;84166;9688;51090;6559;92922;1009;221188;283847;999;1001;64174 ;55282;57610;55512;6645;6483;79613;11060;342371;9785;100130894;342372;83449; 55697;55565;463;10428;11345;2734;55159;79726;162239;84937;124359;83657;1012; 80790;83693;123872;8720;54550;5336;9914;23406;1327;10328;83716;3394;9764;400 550;64779;58189;55625;79791;57338;100288525;124245;29123;27132;54849;9780;2 175;2622;6687;22980.

Cromosoma 17:

388341;25979;284124;83450;23164;9611;125144;9487;5636;10743;7732;55244;9252 1;9706;23326;57336;136;9912;284040;1352;60528;201158;284034;9955;9953;93649; 5376;64518;54902;57335;245;59344;255877;1107;8522;23135;8735;81565;23533;948 2;7157;124739;146845;489;55421;23125;10749;4927;5023;83394;9135;201305;7442; 162514;29;8447;64359;390756;5306;9501;146760;23293;114826;55275;7531;40;5573 1;51379;26284;8844;399687;4642;4763;51701;57532;57649;6147;6830;23512;31;163; 256957;2064;84961;79893;6928;22806;284100;5469;80179;93210;57125;5892;11758 4;146857;342618;162394;11276;8148;146862;22794;284110;9862;339287;7067;47;90 01;317719;162605;125115;284116;81870;6605;6776;6777;1394;80174;1845;23131;28 4058;100128977;4137;4905;113026;6521;7343;124872;124989;996;80279;10642;383 7;100272146;404266;124995;9520;8631;6668;56934;54799;11143;9043;162461;5109 6;162282;339210;124540;22843;252983;1213;51136;51174;54828;84669;10238;1655; 2081;81033;4215;64750;92335;26115;55852;201134;8787;23460;10351;10350;2186;9 931;100499466;26207;5578;400619;100499467;5608;201266;283987;23580;642843;6 4446;3396;3993;9400;114804;54549;55808;10610;146664;6397;146712;84733;55036; 284001;9267;8632;388428;284207;146713;5986;57521;6448;124565;125058;57690;5 7602;56270.

Cromosoma 18:

374860;753;55125;63895;2774;4158;65258;5771;8731;56907;23253;8774;4729;9989; 11031;100192426;5797;79822;9229;23136;91133;284217;339290;642597;56651;2709 8;81035;84034;23347;9984;7298;9097;7525;85019;80000;3909;57534;5932;80816;37 4864;1828;1829;1830;147409;1837;64762;8715;80206;2589;125476;647946;10982;55 197;5289;6014;26040;6563;498;147339;54808;9811;57724;494470;220134;4200;6925 ;5205;23327;9480;147372;89778;5055;8710;79839;643542;220164;29090;1528;64404 1;125704;201456;10194;55628;22850;374868;284274;9150;284241;100130522;4155; 84552;7776.

Cromosoma 19:

388524;90649;148213;100287226;7643;7644;81931;148198;8907;84167;125972;1052 3;27151;199786;26017;54815;79709;93323;9441;4650;115861;80714;25796;23025;11 7286;388512;8529;4051;30817;84658;4218;9524;7171;79173;407018;65249;23370;77 3;1264;1785;1786;1994;1995;326342;115704;84467;3385;7087;3609;3643;80131;510 73;94025;5141;92960;10908;9545;125950;57139;57153;26526;7297;7730;79230;1481 56;115950;729648;81616;8943;1820;85300;997;10036;2527;126326;23030;54531;490 2;23396;5802;8498;84839;5990;6294;9667;8175;6449;360200;9322;115196;83636;87 25;9745;84079;147991;55094;9710;26065;5184;126248;22847;4099;284406;7705;849 24;126231;163115;23094;83889;80776;593;90273;1089;8857;23646;57716;5669;6534 92;57731;125931;388550;23474;3783;284344;5329;5672;5673;5676;5678;7515;7771; 7638;7769;284349;284346;388552;9704;1762;24139;90332;2909;64344;388553;2843 52;57787;80207;8189;84335;587;374920;22900;29998;259307;3748;3978;79784;2363 6;8605;54922;23521;728658;114132;400709;57030;28968;79735;55260;54795;7288;5 1231;25888;3036;5518;8778;946;147660;162966;81856;90321;388558;55769;59283;2 9924;3904;114823;11027;10859;11006;338321;7137;284415;2282;147670;204801;51 78;100169890;10155;140612;23619;7693;7694;57343;147686;79744;388566;27300;1 62972;201514;80095;63934.

Cromosoma 20:

84532;57136;1473;164380;140838;63908;22981;5834;79953;22803;55184;26074;513 40;92675;58495;55857;57186;54453;10483;57419;27131;140836;631;11034;51575;55 614;140733;5126;55304;55617;182;54675;55612;54363;84515;146;8455;25943;11327 8;57593;2280;100289473;57506;5173;149830;5786;642636;343637;128646;9962;705 3;343641;22888;64601;79175;598;51654;84701;245929;22919;5326;51297;9777;1643 95;191;9139;11190;8904;55741;10893;10544;22913;84905;79913;140710;56259;3929

;51230;26051;57148;58490;9675;128434;84181;60625;11122;7150;23051;63916;2139 ;26013;79015;8202;11142;10955;55959;84969;90199;7529;9334;3745;284751;57580; 55905;23315;6780;10079;6790;8537;55816;4773;5203;128553;7764;655;140690;5554 4;81030;116154;55370;11047;128826;60437;1002;11083;3785;63930;4661;10014459 6;128414;4987;9885;55251;51750;63910;140685;57473.

Cromosoma 21:

391267;54033;388815;140578;4685;5651;29761;54072;9510;11096;351;116159;2897; 58494;54148;29104;193629;10600;54067;56245;59271;114036;54065;3455;3460;358 8;64968;54070;6526;8867;140290;7074;757;54102;9980;3753;23515;1827;54093;235 62;84677;3141;3772;6493;10317;25825;54014;1826;2078;150084;5121;9619;104;568 94;54058;85395;80781;23181;29947;11077;8888;114044;378832;54039;5116;5152;53 16;8568;6285;6573;54020;6612;7109;53347;7327;10785.

Cromosoma 22:

23786;128989;8318;27443;54487;84861;5594;51586;57553;5902;7332;29799;7625;27 81;96610;9647;27156;140883;613;23523;85379;644165;91316;440822;646074;9609;1 29049;23384;255349;157;89781;23760;23544;23331;253143;4744;4771;23481;5988;1 0740;266629;8542;254240;114904;51493;339669;150297;10369;1439;9681;8664;257 93;11020;91464;9215;4627;23543;10737;6523;8224;7533;8911;1454;27128;150350;9 402;400927;57591;23467;5435;6122;10454;50;27254;1727;64800;150365;27351;2377 9;9620;55007;2192;10762;29780;112885;55615;553158;25813;25771;25817;284933;3 48645;644186;386593;1375;54456;85358;85378;9889.

Cromosoma X:

158584;550643;169981;10075;23096;347365;9500;57477;28952;50943;2543;643832; 56850;89801;57232;60506;645090;286464;1756;5638;80231;2710;5165;5251;6611;38 9840;5160;6197;6792;4810;6247;8905;2187;4281;8481;3730;57502;416;4267;401577; 207063;8225;55344;28227;142689;55613;1896;1947;27112;9754;6567;9383;7503;340 533;158866;538;546;254065;5230;79983;340562;7552;117154;56062;286499;27328;1 730;695;2717;55998;6173;27286;441509;100302155;51186;1287;1288;2986;26280;18 6;9949;91851;1641;5063;84187;8450;57481;90293;3920;4694;7737;65109;2892;4952; 4068;51114;90167;2719;3251;55796;9459;2258;10479;7547;139081;158521;494119;1 39067;441525;79184;1069;2157;65991;139716;2556;100272228;4204;79057;8277;55 217;7411;7739;10838.

Cromosoma Y:

83259;5616;90665;83866;252951;6192;7544;64595;8287;22829;7404;246126;8284;90 86;159163;140032;246119;83868.

Una realización aún más preferida del segundo aspecto de la invención se refiere al método donde la detección y/o cuantificación del paso (a) se realiza mediante la detección y/o cuantificación de al menos un polimorfismo genético. Una realización aún más preferida se refiere al método donde la detección y/o cuantificación del paso

(a) se realiza mediante la detección y/o cuantificación de los polimorfismos de la tabla

2. En adelante nos referiremos a ellos como a los “polimorfismos de la invención”. Los polimorfismos de la invención se encuentran localizados en las regiones cromosómicas de la invención. Los polimorfismos podrían ser polimorfismos correlativos a los indicados con un intervalo de más menos 200pb.

Tabla 2. Polimorfismos de la invención: polimorfismos de nucleótido único o SNP (n=14933) identificados con las referencias de la base de datos “Single Nucleotide Polymorphism (dbSNP)” del “National Center for Biotecnology (NCBI)”

rs6650104, rs12565286, rs12082473, rs950122, rs4075116, rs9442385, rs10907175, rs2887286, rs6685064, rs1695824, rs7540231, rs3817856, rs2272908, rs12141314, rs7511905, rs2803285, rs7513222, rs3107146, rs1496555, rs2843130, rs10910060, rs2985862, rs10910093, rs6684865, rs10909872, rs729045, rs12063033, rs9782915, rs1338382, rs1109251, rs7525173, rs4648453, rs2376495, rs10492941, rs4648462, rs2455122, rs2500274, rs17399569, rs2487681, rs41495053, rs13375075, rs1128474, rs3903158, rs1181876, rs1891937, rs6663840, rs12734459, rs12079672, rs3935559, rs3856168, rs10492944, rs966321, rs12057139, rs3912752, rs619729, rs13375764, rs780983, rs10489134, rs4475768, rs12724170, rs13376005, rs1418632, rs709184, rs3913319, rs770710, rs1875037, rs17028749, rs4845825, rs806104, rs3789565, rs7531562, rs10864393, rs10489535, rs6682058, rs17361670, rs3789491, rs11801103, rs10864548, rs3007421, rs2986739, rs4908901, rs1556036, rs7549198, rs278020, rs11122119, rs17027008, rs7546903, rs41447147, rs10128022, rs7544004, rs11120896, rs11120902, rs845222, rs10492962, rs9919223, rs227163, rs7516775, rs225100, rs10489450, rs10489451, rs12093176, rs2078288, rs1107284, rs301791, rs172531, rs10492966, rs10492964, rs12024032, rs17032767, rs6577525, rs10864368, rs10489436, rs2268172, rs11121390, rs10492967, rs12405873, rs12561781, rs7413464,

rs9430174, rs6540967, rs11121472, rs6541017, rs10492968, rs935073, rs1372106, rs1220388, rs2890358, rs9430244, rs10492969, rs946503, rs10492970, rs3748578, rs3737155, rs1307494, rs669701, rs622623, rs67969, rs205474, rs10489424, rs2387420, rs1281014, rs12085319, rs11121675, rs7556039, rs1194820, rs2273336, rs41274510, rs12122678, rs7526649, rs11121703, rs2817637, rs2817613, rs2817611, rs10864520, rs9430591, rs6667720, rs2076001, rs873458, rs652284, rs17037861, rs3765339, rs10492976, rs11121906, rs17038046, rs6659122, rs2076216, rs2223390, rs1063776, rs1856638, rs7525044, rs1418856, rs10927559, rs3013086, rs2940305, rs3856278, rs16852000, rs10927910, rs1980472, rs2697967, rs10489147, rs16853528, rs10489144, rs4631686, rs16853880, rs10492984, rs11584308, rs3892594, rs2105239, rs10927460, rs4661291, rs10927468, rs10803289, rs1473680, rs10489353, rs1533980, rs2807562, rs10492985, rs16851160, rs12138732, rs4661327, rs4661614, rs17377023, rs10489961, rs2042370, rs11583306, rs41486146, rs556258, rs848208, rs926619, rs10489599, rs10489598, rs650298, rs2773181, rs1022580, rs2076616, rs2977313, rs10492990, rs6678862, rs4311853, rs223192, rs708087, rs10492995, rs3007734, rs725389, rs10489153, rs2236815, rs4912075, rs1570857, rs2274000, rs951908, rs10489533, rs2223702, rs2013249, rs881246, rs10492997, rs4912106, rs10917469, rs4508039, rs2792029, rs7531524, rs2854108, rs9064, rs16823805, rs660423, rs645496, rs472055, rs10493001, rs2320590, rs10493002, rs1110240, rs7523514, rs6703227, rs6692244, rs1780324, rs7535497, rs950922, rs1384673, rs2315930, rs4654770, rs2445138, rs10493011, rs7516175, rs6692586, rs3845520, rs12135629, rs10489564, rs2235546, rs16827981, rs2806561, rs639802, rs646193, rs716243, rs3218177, rs1579047, rs6679217, rs2902667, rs571479, rs16828744, rs6424140, rs6693386, rs4649175, rs4330872, rs544030, rs10489438, rs1555220, rs966102, rs11547, rs1830962, rs1053359, rs9689, rs1053361, rs926438, rs3924486, rs12075373, rs1267223, rs12043011, rs1044183, rs17163310, rs1938404, rs4585968, rs2045343, rs17162404, rs11247612, rs4596924, rs12752623, rs7516721, rs6598886, rs6598887, rs4908343, rs6658795, rs2985334, rs2153165, rs10493040, rs7548622, rs997550, rs2319403, rs10489445, rs6422671, rs1111382, rs10493041, rs10493042, rs4949522, rs267689, rs370325, rs10489685, rs1406862, rs2142716, rs587527, rs1188414, rs724512, rs4551635, rs7549339, rs4949202, rs4949391, rs1995585, rs4949208, rs10914387, rs1320580, rs10493048, rs10493049, rs10493050, rs620713, rs699004, rs9500, rs1149128, rs7534135, rs10798953, rs10493052, rs11810916, rs16835557, rs1773031, rs7542533, rs481776, rs491586, rs1441523, rs10493054, rs1325245, rs10489913,

rs1108929, rs10489915, rs12025252, rs7340067, rs1382600, rs9286953, rs1771363, rs4653036, rs728449, rs10493059, rs618675, rs10489658, rs10493066, rs3768336, rs10493068, rs606889, rs11263842, rs683622, rs200842, rs408986, rs11263860, rs6425978, rs10796882, rs3917976, rs16823161, rs6425992, rs4653197, rs4652921, rs479714, rs479779, rs6671364, rs1542885, rs1411931, rs9253, rs2360010, rs1010805, rs569791, rs7544568, rs898979, rs2480697, rs1891851, rs10493081, rs2252153, rs1329818, rs3011203, rs11210953, rs10890297, rs716197, rs10493084, rs4360495, rs9438982, rs4418560, rs6422258, rs4475740, rs7554809, rs260970, rs626520, rs16825887, rs4660543, rs16826012, rs7539285, rs6670779, rs16827078, rs7516571, rs12121804, rs375007, rs209583, rs4660408, rs10158384, rs823681, rs12408769, rs7515340, rs2300650, rs213744, rs10493093, rs2363810, rs3845572, rs10493095, rs10493102, rs7527409, rs10493101, rs2148635, rs681511, rs811461, rs189426, rs953194, rs634905, rs1393009, rs6698350, rs10890200, rs2809656, rs12024669, rs10493113, rs12044179, rs16829937, rs11210726, rs1681855, rs5031048, rs841396, rs610200, rs2367190, rs3862227, rs839763, rs7516647, rs9326136, rs10493116, rs3853364, rs6672105, rs3866642, rs17381720, rs272531, rs270754, rs270703, rs263975, rs7519454, rs7535347, rs346732, rs1698295, rs3009974, rs34398124, rs2096437, rs7535487, rs1771551, rs10493120, rs4660306, rs4073846, rs785506, rs2405335, rs2405340, rs1343294, rs2245122, rs6795, rs2622928, rs560540, rs949540, rs10493129, rs10493128, rs6672725, rs12129836, rs10493130, rs10493131, rs41394646, rs2275310, rs10493134, rs10493135, rs1934388, rs3888843, rs17387164, rs3789586, rs10888700, rs17106353, rs11205760, rs12089747, rs2095864, rs11205784, rs6588394, rs6663781, rs1999230, rs17397993, rs10493156, rs11808604, rs10493157, rs1615838, rs2842586, rs2251411, rs10493162, rs1288706, rs10493165, rs10493167, rs10493168, rs6588430, rs17107307, rs10493169, rs1332776, rs1044365, rs7528867, rs7530287, rs6679819, rs17107767, rs1288420, rs3766793, rs1288344, rs869987, rs10493173, rs10493174, rs2316189, rs797910, rs1181204, rs6588494, rs1018402, rs17109656, rs2500332, rs13312, rs207160, rs1499680, rs1695943, rs10493197, rs10493195, rs769979, rs2767512, rs3972660, rs1165520, rs10493191, rs7349129, rs10489776, rs10489774, rs778124, rs522532, rs10489464, rs502350, rs542873, rs2764664, rs1408145, rs2897383, rs722187, rs1202762, rs1202790, rs1325445, rs10493235, rs873989, rs1416347, rs558475, rs2406648, rs10493268, rs1408478, rs1426081, rs10493275, rs642885, rs10493277, rs634125, rs2499509, rs1320529, rs7523497, rs10493324, rs10889332, rs1184865, rs1168013, rs7522249, rs11207995,

rs12563308, rs6693289, rs17124784, rs952998, rs10749738, rs12021563, rs2179811, rs855352, rs10493348, rs2819175, rs1390116, rs673023, rs10493353, rs856283, rs1073712, rs10489902, rs10489900, rs10489899, rs705551, rs705568, rs10493357, rs41507244, rs10158195, rs2274944, rs3790541, rs3014983, rs553002, rs6588109, rs10889522, rs10493415, rs958938, rs1498350, rs1570838, rs4553158, rs1074265, rs10489632, rs1885279, rs1321156, rs2012235, rs3762282, rs11209310, rs2249370, rs17130903, rs288929, rs4649998, rs10889826, rs12035355, rs602495, rs875727, rs622721, rs17090700, rs7540384, rs2007130, rs591031, rs2125775, rs577674, rs2801328, rs10493489, rs11210252, rs11210303, rs17094112, rs1909067, rs10493561, rs627494, rs10493564, rs679018, rs10493567, rs1522621, rs10493604, rs10493605, rs10493606, rs1389789, rs1166704, rs1166700, rs657954, rs10493607, rs10518590, rs10518591, rs12142366, rs10493623, rs10493619, rs7545517, rs1906280, rs10493624, rs7525498, rs228556, rs10489652, rs10493656, rs10493654, rs10493652, rs722589, rs10493650, rs952309, rs2147085, rs4650488, rs10493681, rs1365523, rs1195764, rs535757, rs4362025, rs7543636, rs7548628, rs11163287, rs785579, rs10493716, rs10493714, rs10489861, rs1768737, rs10489507, rs2057084, rs1324485, rs10493742, rs2892811, rs582201, rs316636, rs170278, rs1575178, rs17129446, rs10489890, rs552483, rs507966, rs7515120, rs2764425, rs1419130, rs4655923, rs400666, rs10493813, rs4656049, rs306322, rs10493814, rs10493815, rs10493816, rs10489887, rs10493818, rs10493819, rs10493821, rs3887068, rs10493822, rs7413158, rs2390734, rs2184588, rs972314, rs975977, rs1077538, rs6680212, rs10493829, rs11581245, rs3843306, rs10489799, rs10489800, rs665484, rs6690703, rs10493848, rs7529210, rs6664544, rs17131598, rs10875204, rs2893200, rs12758175, rs17131614, rs11589858, rs2031225, rs12133576, rs1081522, rs1323626, rs6541379, rs11164940, rs2493642, rs2781572, rs7554714, rs1687947, rs11165120, rs2391467, rs10399820, rs4148057, rs2798926, rs10493876, rs2802096, rs3912920, rs10493879, rs7550014, rs1265169, rs6667676, rs7540821, rs4615892, rs4950076, rs6593619, rs2024804, rs676040, rs945826, rs10489560, rs564164, rs3108718, rs3935599, rs7533706, rs161982, rs613721, rs10493885, rs10489741, rs10489742, rs2256459, rs957841, rs1575801, rs3945004, rs10489798, rs3791010, rs10493887, rs10493888, rs2200871, rs1577897, rs10875089, rs2786781, rs10493895, rs10493897, rs1198575, rs10518654, rs10493899, rs2263255, rs10489931, rs7512321, rs2163667, rs17610202, rs12726628, rs1188734, rs10493955, rs396954, rs7514564, rs923697, rs1613556, rs12760689, rs2197445, rs6683989, rs2211295, rs6662872, rs7515984, rs1415092, rs10493979, rs1341899,

rs2375899, rs1935268, rs2791997, rs1856778, rs1934699, rs1934710, rs10493982, rs512945, rs1415349, rs17017787, rs1176950, rs6693617, rs10494018, rs10494020, rs10494025, rs1710807, rs10494030, rs777057, rs6703921, rs790972, rs7526090, rs17017153, rs4915129, rs10881424, rs17017313, rs6697697, rs345277, rs1219776, rs1777463, rs10494087, rs1012840, rs536912, rs578262, rs616378, rs10494103, rs2359246, rs577953, rs10494109, rs9726866, rs1282314, rs325906, rs2278578, rs1043096, rs680025, rs2995765, rs1759687, rs2932529, rs10494148, rs17031214, rs1886503, rs1088716, rs699670, rs1342652, rs12049447, rs12030900, rs41469244, rs3765598, rs1217414, rs7539947, rs17035658, rs11812016, rs1325510, rs1937956, rs35575576, rs10494199, rs10494200, rs953119, rs1289944, rs3820500, rs17037839, rs17037856, rs1573160, rs17037870, rs10923496, rs1146333, rs1359384, rs1779414, rs12757149, rs1779453, rs10923698, rs10494217, rs2799757, rs1409158, rs10494218, rs17023211, rs10923748, rs4387216, rs10923759, rs10923767, rs593911, rs10494231, rs17024340, rs2994815, rs947268, rs10923915, rs835571, rs10923922, rs3795666, rs17024559, rs4659250, rs7532615, rs1832558, rs6600671, rs12033387, rs10494236, rs6692726, rs4106410, rs3103458, rs6700467, rs2660543, rs745937, rs2653711, rs10494237, rs1778121, rs2762736, rs10494238, rs1625255, rs2799304, rs10494239, rs2596289, rs2603881, rs856478, rs7211, rs10494241, rs2282014, rs2318300, rs1284300, rs6665580, rs2354432, rs7553950, rs17160448, rs867270, rs33965274, rs1417280, rs791272, rs10793705, rs17160783, rs11588570, rs9659102, rs7517103, rs3767628, rs3736082, rs11205331, rs6681679, rs1776273, rs17648533, rs11588221, rs12116970, rs7517, rs7529194, rs12063547, rs16827741, rs3768015, rs771197, rs4970989, rs6694158, rs6674970, rs10788804, rs2495391, rs10736380, rs16833336, rs7533032, rs12031503, rs1196351, rs3204344, rs3923394, rs868867, rs2280471, rs3811417, rs1003107, rs16833797, rs3814299, rs6679449, rs4845313, rs1888964, rs11801996, rs2771112, rs3014863, rs3006432, rs12032914, rs1218585, rs7525580, rs4845406, rs11264355, rs7522860, rs2985714, rs16837380, rs1171564, rs2150906, rs2274497, rs16838717, rs1633149, rs432611, rs10489824, rs1112915, rs7512592, rs11265187, rs4492615, rs4656236, rs2501330, rs10494336, rs10494338, rs10494341, rs2274185, rs10494343, rs12076318, rs1041067, rs1265883, rs6413899, rs412965, rs2070151, rs10494357, rs1394070, rs924777, rs10494364, rs10494365, rs10494442, rs6666930, rs2485399, rs2485404, rs10800114, rs16848502, rs4575063, rs1343295, rs10494460, rs10494461, rs12562144, rs11582457, rs10494464, rs17427767, rs1583978, rs505012, rs579100, rs858817, rs926265, rs3917406, rs10489180,

rs10489177, rs10489175, rs546894, rs951490, rs983118, rs2250471, rs1332966, rs1113231, rs10489248, rs10489249, rs10489252, rs1980488, rs7513103, rs2038479, rs10489299, rs2181624, rs10489298, rs2757506, rs10489287, rs7533968, rs41397546, rs12077529, rs6664864, rs333422, rs7523516, rs913687, rs10912843, rs10912847, rs10489305, rs227521, rs10489219, rs10489224, rs2862033, rs1252070, rs1885646, rs3131326, rs4072161, rs3856043, rs579474, rs10047059, rs963607, rs10913522, rs10913531, rs11805590, rs1510266, rs4342816, rs722321, rs6693257, rs3922812, rs2773080, rs10489860, rs1856968, rs10494521, rs2209922, rs10494522, rs3737813, rs10494525, rs10494527, rs7536470, rs7544774, rs10494535, rs10494537, rs998378, rs6686466, rs3814337, rs472193, rs4652791, rs10494563, rs10489762, rs1184639, rs10494564, rs2148620, rs3820689, rs1285511, rs2154386, rs16827144, rs2891285, rs6687201, rs10494616, rs10494620, rs4845303, rs1935654, rs10494627, rs9287136, rs1438523, rs1185678, rs6683411, rs10494647, rs997973, rs10489877, rs1933703, rs10489519, rs6657407, rs10489515, rs1231746, rs10494678, rs6686086, rs10489941, rs10489781, rs41516151, rs16835796, rs10489782, rs866059, rs1331126, rs10801371, rs727954, rs6661271, rs12139828, rs10494718, rs1542731, rs672727, rs613595, rs17667796, rs7538519, rs3904951, rs449847, rs6428369, rs1886627, rs1421387, rs16841846, rs1747823, rs2065150, rs2146334, rs10494765, rs10494768, rs2816987, rs10494808, rs10494809, rs1524161, rs10494811, rs16846446, rs2790114, rs10494815, rs9287107, rs10494822, rs10494821, rs7519783, rs10494828, rs6703834, rs832177, rs10494830, rs603836, rs1327017, rs654631, rs239978, rs676270, rs2361453, rs10494835, rs4072661, rs10494836, rs7541392, rs4245713, rs2298261, rs10920514, rs4950894, rs6688148, rs10494839, rs11584217, rs10494840, rs722915, rs2244783, rs7547716, rs6665383, rs10494841, rs10920635, rs6670438, rs1541252, rs2236552, rs11240620, rs6700051, rs10458591, rs6674877, rs3753855, rs3862948, rs1105386, rs10736841, rs10494861, rs12741494, rs1928442, rs16855560, rs1338623, rs10494870, rs7513290, rs10494871, rs7539751, rs10494872, rs4245717, rs7520276, rs16856186, rs10494873, rs823123, rs708726, rs1891092, rs12096500, rs7364618, rs10494875, rs10494876, rs3849276, rs7552033, rs10494878, rs10494879, rs2135923, rs2940252, rs1762467, rs17012379, rs12408989, rs10494914, rs9308407, rs10494915, rs1330232, rs4844763, rs1933612, rs10494918, rs10494919, rs1157819, rs2884066, rs7535955, rs10489339, rs10489340, rs3753513, rs724054, rs1413698, rs10489346, rs2130627, rs6540630, rs1343144, rs1160575, rs2047708, rs10494932, rs4951522, rs1361031, rs753647, rs894853, rs785318, rs10494942, rs4951434, rs10494947, rs10494949,

rs10494950, rs2358452, rs1389371, rs10019, rs585428, rs493894, rs2137424, rs4951630, rs17724965, rs3768548, rs2291772, rs1391550, rs1187780, rs10494958, rs2165131, rs4342822, rs853753, rs11120420, rs9429920, rs12087246, rs10494992, rs1339405, rs10494996, rs10494998, rs10495003, rs2364861, rs10495018, rs3767681, rs378340, rs1512581, rs1606357, rs4078266, rs4360581, rs2813675, rs2576262, rs8179298, rs1816565, rs867409, rs1416531, rs10495040, rs2815211, rs2646828, rs2810777, rs1933642, rs3902857, rs3892225, rs6658473, rs725033, rs1603059, rs259479, rs2788271, rs1546207, rs10495117, rs10495129, rs17048992, rs1764850, rs1625084, rs1256633, rs1256616, rs17049050, rs7539768, rs3748633, rs1524632, rs6669007, rs3767661, rs11118490, rs34406824, rs2808022, rs2789792, rs4142940, rs6541127, rs6541172, rs7511784, rs9431455, rs3923935, rs3890717, rs10495176, rs11118750, rs17010438, rs12036305, rs2090649, rs10916301, rs1506073, rs1805409, rs10495248, rs6684472, rs10495250, rs6759, rs2313007, rs1892490, rs10495264, rs4500280, rs1495852, rs4306097, rs7543551, rs10495278, rs4581279, rs241305, rs241360, rs9726077, rs1998068, rs16851620, rs11577278, rs12138442, rs9431663, rs16854007, rs6676401, rs9725346, rs16856539, rs14739, rs17563158, rs2812482, rs630891, rs613126, rs10489788, rs10489789, rs2243963, rs3738541, rs965399, rs10925310, rs2819770, rs1891246, rs7525233, rs7520520, rs811545, rs531322, rs2499573, rs923554, rs10495409, rs688278, rs1340465, rs1416385, rs1338927, rs6687490, rs1287293, rs10495406, rs1564505, rs10495441, rs1912231, rs1112902, rs2105233, rs2790645, rs4570412, rs10495471, rs10495472, rs10495473, rs4659986, rs6696418, rs10495474, rs4628499, rs9287251, rs646355, rs615141, rs7419051, rs7367532, rs12043626, rs1333691, rs4412580, rs10926897, rs6679275, rs6429388, rs2491853, rs7549760, rs6429411, rs4469702, rs4658558, rs6702201, rs10803140, rs2039839, rs897959, rs1379700, rs2881274, rs1319790, rs6696289, rs11807869, rs1317297, rs1416089, rs12404212, rs12038162, rs1197650, rs10924692, rs3124089, rs9426209, rs6693529, rs3844079, rs2892054, rs1192832, rs946187, rs1306161, rs1175996, rs3862188, rs841170, rs1552818, rs2184991, rs2387370, rs1933162, rs10888356, rs946767, rs1544176, rs7418152, rs1416991, rs7415479, rs3114107, rs2387786, rs2892355, rs12748771, rs11205411, rs2511, rs12043949, rs11127467, rs300735, rs3791220, rs7573495, rs1511324, rs907302, rs1316288, rs6712649, rs6746997, rs13401599, rs4561699, rs7420683, rs10519477, rs7582140, rs4854183, rs4854187, rs4482520, rs2315626, rs9287671, rs10495525, rs10495527, rs10495529, rs2882452, rs10519719, rs4669048, rs306163, rs4318360, rs10495577, rs10520062,

rs10495579, rs10520085, rs10520098, rs10495585, rs2033875, rs10495638, rs1871616, rs1897912, rs715121, rs1529596, rs7586537, rs10490481, rs2080807, rs6733850, rs7595922, rs2380707, rs10495647, rs1427682, rs6716843, rs10495650, rs4832591, rs7591938, rs1850147, rs1474007, rs871360, rs6721286, rs10495655, rs287302, rs10495663, rs1401705, rs10495666, rs951376, rs421302, rs4038130, rs10495667, rs1991315, rs9306855, rs9306858, rs300179, rs11096490, rs9306861, rs3788961, rs6705213, rs6750415, rs10514631, rs10490753, rs877830, rs1370587, rs7563410, rs1191778, rs10495701, rs973128, rs2072464, rs10514649, rs2289084, rs16988102, rs12713600, rs570877, rs7575840, rs312952, rs312970, rs447986, rs10490609, rs7579766, rs10490611, rs918897, rs10495719, rs4666171, rs1022378, rs4541280, rs2338780, rs6718867, rs6743484, rs1509384, rs10495731, rs6544021, rs6735643, rs1449965, rs10495743, rs10495745, rs4665606, rs7560892, rs2551321, rs10490752, rs6748701, rs9309386, rs9309437, rs10495756, rs10495760, rs1275963, rs1866559, rs1528533, rs1881396, rs7592580, rs1395324, rs2337699, rs10204081, rs10495765, rs10495766, rs4549034, rs7475, rs6737027, rs7589735, rs4577244, rs13426140, rs11683284, rs11694452, rs2339420, rs1104869, rs1528424, rs6750752, rs11691898, rs10495772, rs4075920, rs3886106, rs1447522, rs6709171, rs10495774, rs829584, rs829562, rs829655, rs829620, rs10495776, rs6742360, rs10514772, rs2280404, rs1474194, rs10495778, rs9308914, rs2365200, rs1530394, rs644736, rs207403, rs932559, rs9308919, rs206847, rs2208532, rs599300, rs546935, rs564310, rs10490357, rs10490359, rs458628, rs3769598, rs2710630, rs17429446, rs10490457, rs2710605, rs17012044, rs2052998, rs11675822, rs7605928, rs17014494, rs10495815, rs10495816, rs10495819, rs10495821, rs1519922, rs10495823, rs10495825, rs4670089, rs2049638, rs10495830, rs7570109, rs10495832, rs4670433, rs10495841, rs1439685, rs10490664, rs964853, rs10490656, rs17020164, rs2307472, rs6724418, rs13431551, rs4670265, rs4952490, rs2217363, rs2374345, rs750651, rs10205005, rs11891490, rs10490553, rs2286702, rs4953697, rs9309098, rs10495900, rs7561287, rs10495903, rs6705604, rs17503541, rs10495971, rs10495973, rs1882345, rs10495974, rs10495977, rs10495980, rs9752624, rs3842845, rs3901491, rs6545274, rs4364055, rs724860, rs17043794, rs1510107, rs10490577, rs10496013, rs1374251, rs10490468, rs10490469, rs2949813, rs9309251, rs805351, rs10496028, rs10496029, rs843666, rs4131218, rs10496030, rs10496031, rs1367295, rs2271329, rs2248749, rs354200, rs17046310, rs6545452, rs10490399, rs1001471, rs17190226, rs10490403, rs6738570, rs10490410, rs9309285, rs10490248, rs6757755, rs10490087, rs10490092, rs10490094, rs10490096,

rs10490107, rs10490109, rs5008666, rs10490113, rs10490114, rs4672289, rs10490055, rs10490068, rs48314, rs9309326, rs10496088, rs1344915, rs10496089, rs702873, rs9309333, rs1177280, rs1729659, rs1059541, rs777587, rs10496092, rs17008940, rs6755646, rs13020375, rs10180228, rs6738590, rs13022034, rs4671638, rs6712836, rs17030062, rs10496124, rs268131, rs10496125, rs840970, rs10496126, rs9309375, rs897875, rs4671137, rs10490194, rs10490195, rs10490196, rs10519071, rs4671761, rs10519088, rs10519090, rs12465866, rs4671784, rs10496156, rs10496158, rs964450, rs2122128, rs10496161, rs10496162, rs1016350, rs7420089, rs13415752, rs4441525, rs2312207, rs357764, rs2542532, rs11126328, rs41398, rs17570040, rs6736153, rs3820701, rs831537, rs4331526, rs13416427, rs11885178, rs205648, rs6546923, rs681900, rs10490314, rs10490316, rs4853154, rs6759991, rs9284780, rs10489975, rs988989, rs439012, rs985343, rs971120, rs872174, rs17013313, rs10520170, rs10520177, rs1922808, rs10496232, rs1434114, rs9309553, rs482533, rs410532, rs1484464, rs1867806, rs7605086, rs17040804, rs10496311, rs10496312, rs10496314, rs1192266, rs1192316, rs1192368, rs4831984, rs10520428, rs894202, rs894197, rs7581571, rs4490185, rs9309645, rs1258439, rs11890178, rs4449134, rs1913671, rs9309647, rs6747173, rs7596685, rs7572313, rs2628473, rs11904280, rs1074883, rs4079660, rs11127111, rs1874940, rs17704088, rs17620193, rs2449367, rs4907301, rs772178, rs17633463, rs2579503, rs10520527, rs6732237, rs10496325, rs6745653, rs1562293, rs10520549, rs953320, rs298900, rs2287049, rs13382661, rs10496365, rs13430096, rs6753046, rs1669536, rs725217, rs6543376, rs10514793, rs2125907, rs1398132, rs1469964, rs10496423, rs826690, rs1724204, rs7591305, rs10496426, rs45479, rs389653, rs1469529, rs12613362, rs10496432, rs3789736, rs6542248, rs793079, rs3762491, rs17045861, rs6724855, rs6542396, rs1559500, rs6720819, rs11122814, rs17005297, rs17390274, rs6736968, rs2278741, rs10496656, rs2083414, rs10496658, rs2404175, rs880436, rs873270, rs10496660, rs2056281, rs7605316, rs10179536, rs10188978, rs7585022, rs4954322, rs9287421, rs10496691, rs10496694, rs997377, rs6713545, rs10496696, rs10496712, rs1562345, rs10496715, rs4954095, rs10172395, rs3896753, rs1564935, rs10496720, rs10496722, rs3791264, rs3814023, rs3791289, rs1344975, rs579670, rs4988172, rs834734, rs6740372, rs2380765, rs2030954, rs13034290, rs7606534, rs2176548, rs2714188, rs2714212, rs6715533, rs10496905, rs2278587, rs827229, rs354728, rs10176394, rs10496948, rs10496949, rs7560928, rs952200, rs1986535, rs2077724, rs3768684, rs1404184, rs13015372, rs6750265, rs4667363, rs6725457, rs17348064, rs6707487, rs4299305, rs10211034,

rs12472472, rs9288298, rs6714832, rs6738659, rs843205, rs707120, rs10497152, rs10497151, rs10497176, rs10497173, rs10497172, rs9288568, rs998273, rs1065594, rs6749926, rs1722663, rs1516105, rs10490561, rs10490564, rs979415, rs2358017, rs1111417, rs10166699, rs6736615, rs608665, rs6739611, rs722944, rs2451280, rs10497232, rs1587805, rs1965757, rs6743067, rs10497260, rs10497261, rs13413326, rs2292609, rs10930170, rs6432836, rs6708364, rs12618634, rs9287860, rs10497266, rs699482, rs9287874, rs6755015, rs7596044, rs10497302, rs2063437, rs10497306, rs10497370, rs1816669, rs10515938, rs741283, rs17702120, rs16859371, rs11683762, rs7606149, rs2356800, rs2102738, rs10497375, rs1400816, rs2357206, rs10497377, rs2171319, rs4427989, rs6755520, rs13005010, rs6730483, rs2580422, rs552685, rs1117725, rs1355880, rs7578920, rs1367224, rs9287977, rs1376874, rs10497430, rs10497431, rs212368, rs1153717, rs1153679, rs10497434, rs6748275, rs10497436, rs2461759, rs10497442, rs4072816, rs35066829, rs6706678, rs10497472, rs9287995, rs10497467, rs4894241, rs894994, rs10497462, rs2364722, rs10497527, rs10497529, rs10497530, rs3731739, rs930620, rs1158872, rs1400826, rs1517709, rs7597936, rs868271, rs17824564, rs10497588, rs10497590, rs16822453, rs10497591, rs7603587, rs9288078, rs10497594, rs17649232, rs3769789, rs7597921, rs10497603, rs16823319, rs10182788, rs715365, rs1527878, rs1527880, rs2368331, rs10497612, rs288264, rs288249, rs2368351, rs3748880, rs10497620, rs7603511, rs16824219, rs6434040, rs4666933, rs826142, rs1817567, rs10497642, rs10497651, rs1526212, rs10497667, rs2370672, rs2029085, rs10497672, rs3795865, rs718259, rs840583, rs3821181, rs10497683, rs1520482, rs10497687, rs7604258, rs10497692, rs7425417, rs16830548, rs6434343, rs5743022, rs3024894, rs41376050, rs41478846, rs2198962, rs10204445, rs12619354, rs6725289, rs6737044, rs2884207, rs2060798, rs2360090, rs10197869, rs17772345, rs4850585, rs16844649, rs1568366, rs3792231, rs9288255, rs767620, rs4241188, rs6738407, rs6708080, rs16826873, rs11903129, rs13031577, rs1369845, rs10497864, rs10497849, rs10497866, rs10497855, rs3851976, rs3754934, rs2080326, rs1112961, rs888013, rs1209409, rs2597900, rs2540427, rs4365446, rs863603, rs231725, rs1465538, rs10497874, rs10497875, rs6743771, rs10490274, rs6718456, rs10497880, rs10497881, rs1468997, rs2336413, rs1113314, rs2113379, rs2300965, rs10490744, rs10490747, rs2359720, rs952242, rs13006150, rs2123294, rs10497891, rs11891423, rs796267, rs10497896, rs10497898, rs920218, rs1347664, rs1259699, rs1057392, rs1036014, rs10497925, rs1473332, rs10497928, rs9288406, rs10490754, rs10514642, rs6727289, rs10497974, rs9283525, rs6731193, rs931217, rs10497983,

rs10514628, rs10490500, rs2032780, rs1023609, rs2970963, rs41329246, rs4452139, rs16853697, rs4674009, rs934152, rs17295848, rs1344600, rs3770497, rs2113828, rs7596562, rs1583151, rs1436786, rs10498139, rs10498142, rs4674696, rs10498144, rs1579694, rs1961637, rs6719826, rs16864505, rs11679834, rs1371540, rs966414, rs4674807, rs1006212, rs10498155, rs717610, rs6436459, rs958380, rs10498159, rs10490512, rs12992690, rs16866170, rs13406583, rs1443670, rs10498195, rs1446461, rs10498196, rs7562564, rs2140239, rs964818, rs1515113, rs7340134, rs7574255, rs12464933, rs7605783, rs1881281, rs7559216, rs1528216, rs10490597, rs10498226, rs6729922, rs10498229, rs1469837, rs7603424, rs1881025, rs9288639, rs7605059, rs2091782, rs999019, rs207671, rs10519380, rs2216531, rs7591410, rs4973230, rs10498242, rs1004868, rs10498248, rs4973317, rs1074886, rs10498256, rs6753112, rs4973397, rs7598759, rs1584460, rs10498258, rs838446, rs4479418, rs1982474, rs896990, rs12694913, rs7565128, rs1973675, rs6437074, rs809639, rs4973591, rs2219067, rs2741034, rs554699, rs6727154, rs4663341, rs1441613, rs1822180, rs1529413, rs2195195, rs737711, rs1865944, rs2316431, rs952608, rs2317299, rs6749436, rs1037397, rs4060591, rs1344766, rs1368202, rs1368208, rs30105, rs2043571, rs10170141, rs4129307, rs2316146, rs1826873, rs3754728, rs903371, rs1446924, rs1374386, rs878133, rs2305174, rs103718, rs1397328, rs6431621, rs4241228, rs4241230, rs843462, rs2412029, rs2352852, rs4129624, rs4130554, rs4676002, rs2120853, rs3821285, rs6717283, rs6747185, rs4247179, rs6437282, rs4073277, rs6733823, rs9973663, rs11691410, rs6738966, rs7424996, rs4973649, rs9683305, rs4685448, rs17019407, rs330893, rs6763169, rs13066393, rs4280626, rs6803398, rs17050649, rs9839671, rs10510170, rs17039609, rs1384224, rs2731522, rs9878112, rs6442751, rs6442753, rs967643, rs2290611, rs9861982, rs1471965, rs2034162, rs1899780, rs1242808, rs964403, rs10510292, rs304073, rs1038639, rs6800071, rs11716050, rs7638397, rs1568170, rs9824458, rs786185, rs10514661, rs10510340, rs10490892, rs345200, rs7650728, rs9876724, rs4441639, rs9823281, rs17049528, rs443537, rs1714303, rs688523, rs447423, rs10510395, rs487865, rs2292250, rs7636823, rs2648550, rs17032440, rs11719939, rs7349536, rs9874535, rs2454512, rs4684782, rs2454513, rs17661459, rs1498091, rs4684814, rs2119812, rs17036842, rs17037981, rs10510424, rs7651599, rs13326583, rs2733584, rs2164576, rs2241780, rs2139505, rs10510428, rs3773491, rs7620594, rs755098, rs903056, rs10510431, rs731578, rs1389300, rs10510433, rs10510434, rs10510437, rs746665, rs2306855, rs2129947, rs6800785, rs10510436, rs2345106, rs3905491, rs4685279,

rs2730363, rs11128782, rs842261, rs9840966, rs7635386, rs9284843, rs9284845, rs6550850, rs17029286, rs2175817, rs2886233, rs6779573, rs1667743, rs6768285, rs9845432, rs1021795, rs17019338, rs10510590, rs7653480, rs4973868, rs1445115, rs7617308, rs953663, rs1434009, rs10510633, rs1495576, rs7653262, rs4131727, rs1367610, rs1393749, rs9854271, rs10222558, rs2305610, rs17028011, rs9843448, rs12630254, rs7634861, rs4074415, rs4678476, rs10514687, rs3736563, rs590711, rs6550222, rs4504126, rs9817221, rs7641020, rs9851801, rs13072205, rs2200675, rs13072328, rs7636049, rs4076478, rs7651646, rs7621085, rs2649747, rs2039845, rs816491, rs541692, rs2137562, rs10510704, rs1590010, rs1527554, rs7621402, rs1598990, rs10510705, rs7637811, rs6779490, rs10510708, rs2371319, rs9311297, rs7633017, rs2029127, rs10490787, rs7623466, rs26349, rs1508207, rs1511955, rs342508, rs2302352, rs10490794, rs6805075, rs10510734, rs4432612, rs6796417, rs9836310, rs7637852, rs6808533, rs7614280, rs7611175, rs6794135, rs4234443, rs7618961, rs2014378, rs2742424, rs2742393, rs4683139, rs10490770, rs17280623, rs17330872, rs10510750, rs4987053, rs6441959, rs6441961, rs3918386, rs3092957, rs3136536, rs11575818, rs10514713, rs9311391, rs10514714, rs7643276, rs319686, rs2247510, rs17787569, rs11130253, rs10510757, rs411457, rs7615736, rs13060192, rs1961958, rs6763768, rs6794085, rs1530733, rs10510778, rs815541, rs1914865, rs2316483, rs6763223, rs9311599, rs6777792, rs11708590, rs11917591, rs1393516, rs10510811, rs1504913, rs1735454, rs9917837, rs9311832, rs10490776, rs10490774, rs4688284, rs2366687, rs7631948, rs9813294, rs486854, rs6792744, rs2020075, rs704398, rs10510946, rs264712, rs6795228, rs10510952, rs332364, rs10510955, rs2871629, rs716189, rs4855418, rs9310167, rs2597312, rs17008045, rs9845197, rs17008142, rs2322168, rs1995453, rs17010909, rs3845867, rs1374871, rs4131575, rs1405663, rs10511038, rs6785246, rs10222634, rs4677461, rs6549701, rs4677483, rs7623707, rs7621729, rs9837203, rs1489103, rs3892905, rs673642, rs959028, rs9867723, rs9812736, rs11925923, rs17016830, rs17395825, rs6769328, rs1387667, rs17017114, rs843940, rs694795, rs7646952, rs1389709, rs2642318, rs11917983, rs1509776, rs1567405, rs1489781, rs959132, rs16840111, rs1584929, rs4317101, rs897185, rs1598221, rs9289735, rs2087734, rs1388639, rs10511148, rs1826349, rs1492009, rs1868203, rs2121826, rs9288770, rs9866279, rs4642127, rs7626615, rs1897462, rs300301, rs3913807, rs9288838, rs9867698, rs17383917, rs1453614, rs10511153, rs9289152, rs813513, rs1352293, rs1911569, rs1586471, rs9878083, rs9810090, rs3886994, rs1458303, rs2317212, rs301956, rs719278, rs1546223,

rs1826351, rs1024055, rs6771271, rs7621627, rs924226, rs11928290, rs11708509, rs7640341, rs10511167, rs1675520, rs9289628, rs1350791, rs10804679, rs6439994, rs2333905, rs1440156, rs278373, rs115931, rs278384, rs10511169, rs2454687, rs1383911, rs10511171, rs4928169, rs10936221, rs17338068, rs1857975, rs518813, rs4683856, rs9838540, rs1479372, rs7636808, rs1440784, rs7640570, rs1584440, rs2895256, rs10511214, rs7628767, rs10511217, rs10511220, rs1457839, rs1172261, rs10511221, rs1612989, rs6783422, rs2921253, rs1373733, rs9845005, rs11927739, rs1875461, rs709532, rs11917650, rs17204920, rs17231712, rs162074, rs2701063, rs7340726, rs16855863, rs4682223, rs9836371, rs10511289, rs7623003, rs10511291, rs1477847, rs10511292, rs2958089, rs17281304, rs1282970, rs173108, rs972553, rs1553191, rs12695295, rs10511327, rs226082, rs1354348, rs10511333, rs2718425, rs7644183, rs12487346, rs6438214, rs1274269, rs1295764, rs10511337, rs10804520, rs13083779, rs4518124, rs4831224, rs9852860, rs17646747, rs1432364, rs13077521, rs6788352, rs11707363, rs16828916, rs12054067, rs35860, rs16829334, rs4687973, rs17471, rs1270209, rs9289146, rs1007068, rs10511398, rs2292170, rs408561, rs10511405, rs9289151, rs3914745, rs13062151, rs6438759, rs4678209, rs4678210, rs9289204, rs10511415, rs725404, rs1470400, rs13434289, rs2717235, rs836846, rs3804755, rs4677905, rs16835592, rs589663, rs2291079, rs1574130, rs10512635, rs2168238, rs9289250, rs10512657, rs2365012, rs4234272, rs1055451, rs1525855, rs4974455, rs6789079, rs809213, rs784736, rs1708232, rs4688838, rs9880759, rs9811418, rs7644173, rs34158162, rs12631517, rs6783392, rs10512820, rs10512813, rs10512817, rs938241, rs938243, rs6439359, rs2133692, rs10512862, rs10512863, rs1839942, rs6806298, rs6439381, rs1201674, rs2078262, rs7628262, rs10512905, rs1534166, rs719893, rs1399706, rs10512935, rs983401, rs36117, rs2400445, rs4678285, rs6807138, rs7614568, rs1371907, rs10935230, rs329384, rs811811, rs6790428, rs1201763, rs6782181, rs6768963, rs4683778, rs6769310, rs4312621, rs6795843, rs3773837, rs1047306, rs13100444, rs890528, rs9838625, rs1344672, rs13074801, rs17638168, rs838621, rs9289666, rs10513212, rs10513215, rs10513220, rs10513233, rs10513234, rs10513235, rs10513238, rs10513236, rs7644767, rs6775253, rs12152433, rs856792, rs856787, rs730837, rs1178895, rs16855622, rs7651550, rs9835556, rs2889113, rs6440272, rs7610711, rs7618904, rs4592991, rs1398776, rs629017, rs9289711, rs1170391, rs2055978, rs7634946, rs13070811, rs1606264, rs12374006, rs16859472, rs9848851, rs2124730, rs7645488, rs9874416, rs1403424, rs1522949, rs275678, rs275667, rs2013929, rs1602827, rs10513378, rs580631,

rs10513380, rs2904301, rs6780053, rs10513385, rs4680474, rs9289863, rs191758, rs1025197, rs10513436, rs10513438, rs6809045, rs6799829, rs2687880, rs579522, rs528581, rs17468698, rs10513447, rs611553, rs1402584, rs10935975, rs1405894, rs1727947, rs357484, rs400529, rs184825, rs9289940, rs16823820, rs355786, rs10490843, rs355756, rs2037580, rs10513457, rs7639012, rs7630004, rs13081372, rs1402731, rs10513465, rs41467345, rs12489430, rs11708859, rs16827388, rs2062608, rs16828468, rs10936112, rs1533401, rs12107104, rs7634185, rs10513542, rs1497763, rs3911714, rs2121721, rs10513560, rs1580254, rs10513564, rs336583, rs464766, rs336556, rs16832385, rs6441379, rs1588020, rs12486357, rs1399898, rs1399900, rs1955090, rs1488175, rs2114547, rs1478007, rs1495046, rs2722638, rs1112188, rs282224, rs6799419, rs17717909, rs12486752, rs13082560, rs12493595, rs6776030, rs4599308, rs3924284, rs9829009, rs1513424, rs1362523, rs4311258, rs10513668, rs41495746, rs7638569, rs7631580, rs10513676, rs6803541, rs507759, rs10513702, rs2286983, rs234040, rs234006, rs10513703, rs10513706, rs6445094, rs1402215, rs1879370, rs12632659, rs41393347, rs4894468, rs7614469, rs10513727, rs9290541, rs9290548, rs10490874, rs9290552, rs10490876, rs10513747, rs28711160, rs6443485, rs9868594, rs1421165, rs1837789, rs9290644, rs920607, rs1372397, rs7621881, rs7647897, rs904241, rs1805644, rs9858365, rs4855022, rs2567660, rs2567644, rs7616477, rs1518922, rs9879880, rs1996547, rs733422, rs1979407, rs1158707, rs766741, rs6793883, rs10513780, rs10513781, rs10513782, rs10513784, rs10451928, rs9843433, rs7633306, rs10513786, rs17217643, rs10513788, rs6773839, rs17289855, rs1457570, rs9842478, rs2049284, rs6788905, rs1879784, rs10513793, rs7639440, rs16857726, rs10513794, rs262983, rs9290776, rs2872249, rs3792583, rs1879259, rs10513797, rs727272, rs725656, rs7625123, rs17205271, rs2268835, rs4686761, rs16860724, rs7628341, rs6782743, rs3935586, rs6444138, rs1868156, rs7623621, rs2280391, rs3846211, rs6787877, rs2228243, rs2378121, rs10513803, rs1624230, rs10513811, rs4686450, rs6781114, rs3892779, rs3901490, rs849752, rs2016011, rs17040, rs850303, rs3914757, rs10513815, rs2123174, rs9830088, rs3907008, rs10513817, rs10513820, rs9842232, rs2030516, rs710506, rs10513832, rs10513833, rs10513836, rs1399614, rs1364593, rs17429491, rs3966009, rs1920241, rs16864641, rs1464117, rs710537, rs9290911, rs837678, rs41488048, rs10513845, rs1374922, rs893054, rs573533, rs472966, rs10513846, rs1425101, rs876234, rs4687139, rs9834809, rs10937436, rs10222616, rs6764850, rs3821740, rs7652346, rs4624606, rs1501603, rs11714258, rs188384, rs9283662, rs2367478, rs2037427, rs281817,

rs753815, rs280543, rs2173796, rs587612, rs612815, rs724767, rs1463697, rs1037928, rs823025, rs952482, rs6437456, rs7628680, rs1961324, rs3796161, rs9825185, rs11918729, rs823511, rs3107727, rs2284890, rs3804138, rs7626440, rs4916561, rs1602, rs17597256, rs3856757, rs7624859, rs1356612, rs10489880, rs338186, rs338203, rs1073726, rs1741949, rs732190, rs2256194, rs6583253, rs635652, rs9325407, rs3749254, rs9873100, rs6605313, rs6763543, rs1320403, rs9325418, rs4097878, rs4497085, rs9884834, rs11735742, rs6826124, rs6599319, rs3946, rs1822345, rs718429, rs6848767, rs1811560, rs10516157, rs935970, rs1904931, rs17164384, rs900019, rs1960426, rs13117476, rs10516159, rs10488835, rs2022303, rs3135095, rs3749467, rs707341, rs17824073, rs2213316, rs382379, rs2051560, rs16843629, rs2857839, rs9291159, rs7440822, rs3025851, rs363098, rs2073503, rs41461548, rs16835627, rs16836016, rs2019908, rs6839872, rs34526488, rs2968669, rs10516170, rs1077365, rs722867, rs10516175, rs726111, rs10516179, rs9291117, rs724858, rs10033106, rs6819148, rs4689160, rs4689860, rs2386113, rs7660416, rs2631723, rs3976518, rs7435086, rs998675, rs7680126, rs10516199, rs734122, rs4697710, rs16870613, rs2109603, rs10516242, rs10516247, rs10516248, rs1842160, rs4698316, rs10516284, rs10021583, rs2041673, rs16892270, rs16892289, rs2247952, rs1075227, rs1477901, rs716985, rs2320983, rs10516328, rs6845544, rs7694311, rs207389, rs207295, rs16871892, rs34833395, rs6839776, rs17542763, rs9998680, rs769273, rs6835555, rs2175068, rs1038821, rs16876760, rs6448334, rs13123844, rs1909475, rs7661189, rs10939045, rs1033102, rs16878322, rs4642237, rs915889, rs6857426, rs4234981, rs1026944, rs6820355, rs17616611, rs292071, rs292084, rs1510715, rs4362890, rs11734446, rs12498151, rs12639959, rs1121414, rs7676021, rs10517209, rs720394, rs10517212, rs9291549, rs6812005, rs4128784, rs954103, rs2221128, rs6818974, rs17081340, rs9685804, rs7689329, rs9306912, rs10517323, rs1459458, rs1160207, rs10517333, rs1714933, rs9306919, rs921853, rs7679959, rs1480972, rs7686175, rs9306924, rs1372156, rs11096802, rs11945469, rs16992035, rs2375951, rs16992389, rs4619901, rs1473364, rs4444866, rs13105969, rs6829898, rs2437357, rs10021613, rs17660729, rs17628224, rs11933196, rs7692356, rs6447336, rs6839710, rs4456994, rs9291300, rs10517176, rs3934674, rs1866989, rs7680746, rs10517188, rs4254743, rs7679148, rs4695256, rs4131134, rs10517195, rs10517198, rs3886429, rs10517200, rs10517201, rs1812964, rs9291318, rs10517202, rs10517203, rs6447614, rs3792623, rs1008277, rs2089509, rs10517213, rs6554058, rs6852236, rs1519586, rs178724, rs784942, rs17657848, rs1903222, rs1459817, rs238312,

rs17051547, rs11939490, rs12513298, rs3733503, rs17675997, rs936690, rs10026162, rs2930103, rs301088, rs2062185, rs17082398, rs10517283, rs7688646, rs6826467, rs17082563, rs1481816, rs6828559, rs4864768, rs6827952, rs10488846, rs2276949, rs4563545, rs2173229, rs904141, rs904130, rs6816309, rs7680283, rs4864540, rs491381, rs7692461, rs2130040, rs962354, rs1387200, rs4272068, rs4865033, rs2726736, rs2899039, rs2412692, rs7671338, rs17797113, rs976640, rs41335053, rs6837469, rs753255, rs956275, rs17086804, rs6554358, rs4865115, rs6856683, rs10006458, rs6855851, rs720429, rs6821445, rs4864596, rs10222715, rs1708768, rs1105434, rs2215480, rs2041436, rs6813346, rs1524690, rs991920, rs1829982, rs2691390, rs2140704, rs2204370, rs9312686, rs17081954, rs10517389, rs343528, rs6554499, rs10517418, rs10517424, rs10517430, rs270226, rs166583, rs10517434, rs3891409, rs2570100, rs2166997, rs2412933, rs951104, rs9312080, rs1502787, rs2137022, rs1511398, rs10517535, rs11938177, rs335339, rs335273, rs335288, rs41357748, rs1565901, rs2343249, rs1462598, rs13105340, rs12644315, rs11728612, rs4320186, rs2046601, rs354875, rs719391, rs1038428, rs10518042, rs6828855, rs17088752, rs17089252, rs17592868, rs969114, rs11942157, rs988671, rs13133166, rs1220703, rs41411545, rs11730719, rs1155690, rs1351094, rs17001289, rs8878, rs17002091, rs11937061, rs4241605, rs17003697, rs17494639, rs10004440, rs6534350, rs6850811, rs723243, rs6847612, rs41470244, rs10033652, rs4128522, rs10516659, rs479065, rs567671, rs11940883, rs4693571, rs12649079, rs4591595, rs11099581, rs11099592, rs3733329, rs2665876, rs11724577, rs9884770, rs9307016, rs9992507, rs2125787, rs236985, rs967552, rs6531975, rs6850409, rs4148150, rs2583984, rs7699688, rs2124622, rs17020802, rs2099701, rs12505322, rs899132, rs11097407, rs4693381, rs8336, rs3805298, rs2438144, rs1043862, rs11723423, rs1444922, rs11097457, rs11097458, rs9996009, rs11097470, rs12642926, rs11097592, rs17027229, rs2034677, rs12650841, rs6831386, rs17027607, rs4374629, rs12507328, rs17028238, rs11727079, rs10516438, rs10035037, rs7683532, rs17216446, rs1803037, rs17595424, rs17028505, rs1154410, rs1042365, rs6855482, rs13110176, rs1893883, rs17028743, rs1229977, rs931635, rs1042026, rs2066702, rs1693457, rs2298753, rs1693476, rs1631460, rs284787, rs971074, rs1154468, rs1979894, rs10021082, rs10516442, rs10030937, rs11935423, rs17029142, rs10516445, rs1032355, rs2282588, rs6813099, rs17029601, rs11945303, rs7684872, rs7676564, rs6828260, rs10516504, rs10516506, rs10488858, rs10488857, rs2189164, rs10488856, rs1973857, rs7654953, rs7654883, rs1392939, rs1425357, rs1405154, rs10516554, rs3108932, rs4956247,

rs17581668, rs2374223, rs10012179, rs4077692, rs1604227, rs4129117, rs6534006, rs717904, rs10516633, rs10516634, rs298923, rs6811017, rs6847160, rs41520948, rs10518369, rs937354, rs1390559, rs10518375, rs1868715, rs991062, rs6854081, rs11944526, rs9999551, rs307022, rs10003186, rs6845502, rs3811741, rs11941857, rs2169270, rs4834226, rs11735810, rs4975180, rs12505447, rs6855813, rs318509, rs11940367, rs2068136, rs337263, rs10034027, rs13435210, rs16998184, rs41425947, rs2939616, rs10519420, rs10519425, rs2406756, rs1526248, rs3849640, rs1112266, rs1124791, rs17050678, rs1112828, rs11733790, rs3796635, rs4863646, rs998310, rs1026048, rs2725778, rs2132845, rs8192100, rs17050877, rs11735182, rs1521496, rs7655290, rs6825404, rs358310, rs3805317, rs1473239, rs3097594, rs3104104, rs12502572, rs2071416, rs3796699, rs2042629, rs6831717, rs10519598, rs1057260, rs10519612, rs7668411, rs17015108, rs1497391, rs1822363, rs7668552, rs1510139, rs10519675, rs2019159, rs4285038, rs1828504, rs970022, rs17516, rs3891822, rs6842889, rs2575572, rs1812175, rs4835265, rs6839123, rs891382, rs7686137, rs2356822, rs6854020, rs10519911, rs17023581, rs2718453, rs7687368, rs4835093, rs4835111, rs17676286, rs3884525, rs5534, rs10021848, rs2070949, rs11099754, rs7340876, rs12374344, rs7668154, rs6535852, rs1552638, rs4585279, rs2227424, rs7690230, rs4696627, rs1002098, rs727773, rs2170646, rs7676346, rs4370087, rs1399044, rs1841272, rs34403855, rs4691370, rs4499662, rs9985638, rs9308019, rs6855620, rs10517740, rs10517743, rs2872528, rs2872527, rs11100372, rs4501178, rs10517748, rs7685984, rs10025949, rs936565, rs17574812, rs4023, rs4691896, rs1441718, rs2276978, rs719307, rs6818281, rs9308066, rs6536755, rs1343754, rs4132054, rs418488, rs390012, rs9312228, rs10517963, rs304359, rs1910881, rs10517976, rs2292734, rs574336, rs719898, rs497179, rs1507167, rs12501568, rs4410489, rs7655924, rs2877448, rs2661925, rs2877579, rs2178300, rs17057767, rs1711989, rs2459617, rs661027, rs10213204, rs17062338, rs7675676, rs7665552, rs1963008, rs2128423, rs11942500, rs3828488, rs17739461, rs10520381, rs1993278, rs6853065, rs6855992, rs4416520, rs17067919, rs4861798, rs4241710, rs17068092, rs6828052, rs1435495, rs1574518, rs4862334, rs10520560, rs17584650, rs2175293, rs793810, rs4862374, rs10520564, rs12498890, rs6843640, rs2306707, rs1376534, rs2130910, rs325032, rs1431935, rs1583219, rs167721, rs322401, rs1158815, rs1352276, rs976000, rs2163398, rs1367555, rs11734306, rs4863348, rs10024926, rs1448742, rs958367, rs4012731, rs722595, rs1982949, rs6812295, rs1496939, rs1566100, rs1037644, rs1869946, rs1350180, rs1993084, rs6849237, rs2318228,

rs7684487, rs1879724, rs2411530, rs11132784, rs7704488, rs6869386, rs10065373, rs9312845, rs7717734, rs9312964, rs1574220, rs1913574, rs2672734, rs2335619, rs6555496, rs1009117, rs16903688, rs16868701, rs4975533, rs10071261, rs4975569, rs4975552, rs12653975, rs6892881, rs6554677, rs4246742, rs2853668, rs401681, rs10052016, rs2937649, rs36987, rs1827192, rs1875194, rs10512651, rs10512645, rs17610178, rs901505, rs16869802, rs16869827, rs16869878, rs13183111, rs1971938, rs160770, rs1215658, rs10512733, rs1864217, rs11134059, rs16874637, rs890768, rs10512779, rs10512787, rs2913363, rs10512795, rs153264, rs6555368, rs2561855, rs950651, rs1826378, rs181971, rs4235565, rs10462830, rs13160842, rs12516822, rs327581, rs10513154, rs990154, rs10513161, rs1866836, rs10513166, rs445553, rs2289849, rs30609, rs27111, rs7706559, rs41502749, rs995765, rs9312913, rs9312916, rs10520839, rs2290993, rs10520841, rs334487, rs248917, rs256893, rs410112, rs31314, rs253341, rs10520844, rs17708295, rs10941533, rs10520851, rs1542127, rs10520853, rs2652571, rs10520855, rs608206, rs448745, rs1857707, rs1394215, rs7730429, rs9885272, rs6891920, rs10941887, rs1987208, rs7445285, rs1685222, rs1707062, rs16900519, rs10520883, rs11746394, rs9293044, rs1829467, rs16891846, rs13164921, rs10520888, rs10520891, rs7715803, rs10520892, rs437652, rs2319567, rs16893488, rs988765, rs2331930, rs2087, rs10520933, rs6859841, rs10520935, rs16896665, rs4132433, rs10051873, rs7448986, rs6450556, rs4128881, rs9292230, rs2548006, rs1363873, rs2554910, rs383528, rs9283723, rs1392445, rs10520976, rs10520975, rs2047725, rs573156, rs7719497, rs6862543, rs10520995, rs1919253, rs696831, rs3811966, rs10521001, rs10521002, rs16873579, rs284766, rs2361391, rs716302, rs1353252, rs1025039, rs700174, rs3756669, rs10512634, rs267769, rs10512648, rs1030239, rs3903407, rs16903276, rs6869867, rs210540, rs3849765, rs10491480, rs10491482, rs2939330, rs905165, rs10512712, rs638563, rs635912, rs4410646, rs16872913, rs10805673, rs10512844, rs2973646, rs1482684, rs10512854, rs2118763, rs10512865, rs10512876, rs1483306, rs1384732, rs10214369, rs10512880, rs1819031, rs7711240, rs4541666, rs6451828, rs11954885, rs6896294, rs1834259, rs16879639, rs1871186, rs246409, rs3212539, rs254487, rs10513012, rs3091252, rs3899797, rs10074134, rs10940509, rs10461609, rs733250, rs2168649, rs6870632, rs16889904, rs1382914, rs329614, rs295561, rs2591786, rs4700036, rs1514578, rs16891519, rs11950223, rs10038179, rs6449683, rs1478490, rs6863215, rs29456, rs16895069, rs3111630, rs7705086, rs12055346, rs281455, rs10515064, rs10515068, rs440292, rs10515081, rs697621, rs16898515, rs2561159, rs6872235, rs282357, rs4354016,

rs399778, rs4704104, rs1500134, rs6453086, rs6453104, rs7703461, rs163026, rs2279010, rs2662378, rs252788, rs1019803, rs163633, rs9637824, rs2195447, rs4703882, rs256810, rs6871340, rs1382375, rs2292013, rs1445748, rs1500226, rs41509548, rs16901059, rs7718617, rs1500620, rs1604089, rs2974088, rs2918440, rs893554, rs17285524, rs16902072, rs13181836, rs12516449, rs4920774, rs7717290, rs13182221, rs2929617, rs2544688, rs2544677, rs4272164, rs1816740, rs357509, rs7716599, rs1560208, rs1645410, rs16868120, rs702844, rs2910779, rs2973403, rs10514324, rs2562515, rs655939, rs1394639, rs6891645, rs10514334, rs2161219, rs13358266, rs1363289, rs10042155, rs17084316, rs3852192, rs3777217, rs248342, rs2161317, rs10515232, rs903380, rs4869279, rs10515235, rs10515236, rs10515237, rs2611742, rs261996, rs261202, rs11960506, rs1421912, rs26504, rs28096, rs151940, rs709668, rs10515251, rs2247650, rs6884540, rs11958159, rs432482, rs1429864, rs11958522, rs278497, rs2548261, rs2400313, rs1833862, rs1588625, rs7447076, rs1993653, rs10515308, rs348405, rs17154752, rs7723689, rs984288, rs12523170, rs17338777, rs1990745, rs17433854, rs7707185, rs34590, rs3797510, rs152608, rs250253, rs975690, rs10515374, rs11951703, rs11952230, rs1015976, rs724784, rs2218071, rs1981815, rs10035116, rs17132176, rs456236, rs10045255, rs450315, rs560063, rs4957631, rs10515446, rs878073, rs10519348, rs17332053, rs3891925, rs1356826, rs285886, rs6885946, rs289026, rs10519398, rs1869280, rs9326938, rs3805586, rs10519432, rs17138670, rs4920906, rs6864548, rs640121, rs4312911, rs7726915, rs193539, rs30058, rs335212, rs10519720, rs337098, rs1428397, rs2081914, rs10519723, rs17764418, rs7725021, rs4835938, rs3805606, rs28114, rs4835964, rs17673487, rs7717696, rs10520116, rs2522393, rs803054, rs10491282, rs10491280, rs997633, rs9327712, rs2260940, rs10515470, rs3860106, rs2237061, rs916803, rs10515474, rs6883335, rs2526150, rs2526152, rs4976360, rs2072239, rs6596289, rs6596299, rs1469067, rs10491247, rs7706155, rs2188468, rs28063, rs2157916, rs10515482, rs9327764, rs10515486, rs6421910, rs11956089, rs7731574, rs10900858, rs13160445, rs17131963, rs891989, rs11739961, rs712166, rs11167798, rs7734364, rs10060327, rs1438733, rs258759, rs853184, rs852980, rs9324918, rs11167810, rs17100309, rs246432, rs9285657, rs312636, rs974692, rs7704225, rs10477239, rs9324949, rs17101780, rs10515541, rs248012, rs11167885, rs192202, rs2190792, rs10491317, rs6890604, rs6580355, rs6897242, rs10515549, rs6863915, rs2839745, rs319217, rs4705449, rs1383167, rs9325031, rs1156700, rs39598, rs10515579, rs10515581, rs4705167, rs7709159, rs3749690, rs9325093, rs10515615, rs9325102,

rs1368384, rs7738035, rs368337, rs10515634, rs10491360, rs10515636, rs10515635, rs216130, rs2240786, rs6876869, rs882663, rs12520101, rs9324647, rs246497, rs3905908, rs998076, rs2304054, rs1529691, rs7349809, rs7702336, rs1824612, rs10515692, rs720985, rs10796, rs6873648, rs10515734, rs10515743, rs3913482, rs17053943, rs3909320, rs10515746, rs884623, rs868988, rs11134778, rs10866659, rs9313633, rs11744800, rs6890471, rs955967, rs1541649, rs11742073, rs10070745, rs6874816, rs4921106, rs2271944, rs2964638, rs2926053, rs12108998, rs17065834, rs13169858, rs1895207, rs10035923, rs4868974, rs1422530, rs1030669, rs2098651, rs1024994, rs10516035, rs10516037, rs2878866, rs4479863, rs7725644, rs2432644, rs2546700, rs764146, rs262880, rs261612, rs261597, rs261056, rs67777, rs1553298, rs4868027, rs10491493, rs891999, rs1347155, rs10516133, rs2002387, rs2249619, rs12517663, rs11134760, rs2004997, rs3805463, rs4868257, rs12153774, rs41408753, rs7736275, rs10516113, rs17064468, rs1363688, rs2381989, rs10516128, rs1422914, rs10516130, rs4868513, rs10516131, rs157474, rs2259307, rs686874, rs2382120, rs9313729, rs871853, rs2241577, rs10516139, rs729423, rs1872895, rs10079303, rs555668, rs691268, rs1000144, rs9313748, rs6887893, rs244730, rs12716329, rs10035180, rs1363405, rs461259, rs2913838, rs10491478, rs190328, rs10516141, rs4129403, rs9605, rs6601105, rs3828686, rs10516145, rs10516143, rs10516142, rs1038143, rs2279231, rs6601146, rs2892344, rs3885614, rs3901874, rs2387724, rs2770994, rs1418707, rs742767, rs6926902, rs2181107, rs7754000, rs950286, rs2493036, rs17239807, rs4959455, rs1932635, rs4997129, rs6908826, rs2210370, rs349098, rs9503145, rs6915706, rs167555, rs4149367, rs9405193, rs4959823, rs2810797, rs4960167, rs10900986, rs742341, rs3804481, rs1286045, rs10719150, rs1285873, rs9392904, rs6923462, rs2815143, rs11962455, rs760892, rs3798696, rs9366500, rs9467011, rs6916198, rs41463746, rs6457200, rs7765241, rs6903357, rs7756513, rs9394270, rs6932389, rs6922296, rs10478723, rs6458503, rs6919577, rs7760579, rs4145562, rs6458814, rs4712047, rs2804921, rs3799924, rs9296921, rs2743870, rs10949309, rs742206, rs13199398, rs1927583, rs16878431, rs236949, rs6931635, rs16878668, rs12198838, rs1413809, rs9358215, rs9366294, rs16882159, rs728285, rs952579, rs1928176, rs10484390, rs4583980, rs2474149, rs216257, rs393228, rs303031, rs186237, rs4464787, rs1165157, rs1165151, rs3830054, rs933199, rs721600, rs10484399, rs9295740, rs10484401, rs200995, rs9295753, rs149971, rs202906, rs10484404, rs1150712, rs1150726, rs742107, rs2157605, rs3095330, rs2517451, rs3131009, rs3130048, rs3096695, rs3130180, rs9277194, rs211456,

rs10807124, rs411136, rs3846852, rs2772376, rs1755044, rs9296092, rs747694, rs4713701, rs2274154, rs9469693, rs2499690, rs2499726, rs12654, rs6691, rs10484268, rs3800472, rs2814983, rs6909637, rs262908, rs10223418, rs262925, rs1541227, rs708024, rs6458008, rs6919087, rs10485029, rs259690, rs10498740, rs4714173, rs6932648, rs12206647, rs303702, rs302617, rs1475114, rs9296318, rs10485042, rs10485043, rs9296320, rs9369213, rs12662449, rs2479723, rs11970772, rs6933895, rs4607417, rs7753265, rs4714560, rs1065236, rs10452607, rs6920611, rs967033, rs16896453, rs2396004, rs1772665, rs831312, rs1096699, rs9296416, rs16896641, rs752073, rs10948112, rs4513773, rs9357428, rs4711764, rs6934989, rs1411904, rs525043, rs618263, rs1021129, rs524492, rs10498757, rs3799979, rs490515, rs1388244, rs16873760, rs1980530, rs9357499, rs995564, rs2143747, rs1867016, rs1345062, rs1442212, rs4714924, rs571247, rs10948378, rs4144559, rs1388930, rs2225204, rs280290, rs2397011, rs1569777, rs10948634, rs1266912, rs16882270, rs2235714, rs426169, rs17672049, rs222455, rs222451, rs16883429, rs9474394, rs2518579, rs2817101, rs9474643, rs3813850, rs7768280, rs228139, rs10484724, rs1925178, rs1925141, rs1925151, rs1988981, rs1321555, rs1964875, rs962515, rs1123892, rs926279, rs726783, rs1224703, rs1224802, rs3902449, rs4928463, rs4928465, rs9342982, rs10498821, rs2782383, rs2843124, rs4496775, rs4552710, rs7750310, rs6453965, rs9353364, rs1482443, rs9353441, rs3003679, rs11965478, rs11965177, rs9362943, rs10944599, rs9453679, rs6916097, rs4580841, rs6940958, rs897405, rs701665, rs9294789, rs2786574, rs4708047, rs2038998, rs6934160, rs779455, rs10485253, rs2225220, rs1768946, rs2153276, rs701697, rs720741, rs829471, rs1410676, rs9293853, rs9293854, rs502046, rs566957, rs6912022, rs617464, rs9343143, rs9447978, rs4706646, rs11752111, rs12206214, rs818290, rs10498917, rs1452528, rs9294111, rs941684, rs625065, rs9448480, rs689389, rs1454455, rs9359426, rs13193950, rs501424, rs1373361, rs16893125, rs16893155, rs9449400, rs7767369, rs169789, rs1180241, rs504593, rs217319, rs2223629, rs2497139, rs2875397, rs9362054, rs6910673, rs9449971, rs12209001, rs7774683, rs1621530, rs9450018, rs2224213, rs7742109, rs9294315, rs7751732, rs9294321, rs10485069, rs6155, rs41398947, rs9362399, rs6926831, rs6910863, rs17453041, rs1746444, rs16879089, rs9450833, rs10944335, rs662847, rs7760757, rs6454669, rs9444679, rs6454749, rs13362816, rs6906855, rs1593659, rs1896234, rs10498980, rs964287, rs1878071, rs9294536, rs1416017, rs7742301, rs783073, rs10485371, rs9294560, rs694537, rs7449883, rs1463675, rs10806484, rs11964667, rs1538283, rs681531,

rs1750603, rs1548760, rs41447444, rs6919139, rs3125567, rs2572106, rs9402648, rs7755791, rs4448102, rs4840109, rs2474254, rs6570772, rs240783, rs12206564, rs1875400, rs240154, rs239243, rs17672397, rs705607, rs626120, rs642398, rs9390754, rs599545, rs7767001, rs176435, rs9285557, rs522447, rs17716287, rs10484477, rs1341126, rs271858, rs4132193, rs6942231, rs7759427, rs10485311, rs964730, rs10499042, rs10484470, rs2066202, rs9320182, rs10499046, rs2024741, rs10872009, rs10485220, rs741314, rs13190753, rs655758, rs911475, rs377436, rs884366, rs1406899, rs10499052, rs3899233, rs829816, rs3823234, rs9398214, rs10499054, rs9374216, rs9400435, rs10485396, rs774568, rs813505, rs2637524, rs9320437, rs2637526, rs4090284, rs9374461, rs13191722, rs1324443, rs786146, rs786147, rs17804066, rs195484, rs195531, rs496311, rs1193609, rs17079625, rs7741789, rs4946322, rs2883773, rs763098, rs9489314, rs1288075, rs10499091, rs807317, rs1417842, rs6899335, rs10499092, rs9320713, rs2606629, rs2816142, rs7741540, rs10499122, rs10499123, rs6929965, rs1535355, rs10485416, rs2611436, rs342655, rs9490991, rs1490359, rs1337868, rs9401780, rs781769, rs752292, rs17751311, rs9388465, rs11963634, rs1262476, rs4895815, rs1262548, rs2503320, rs17056470, rs1508453, rs11751015, rs7454382, rs7740188, rs11154532, rs2064873, rs4897412, rs6908659, rs3777435, rs1931004, rs9493157, rs170881, rs10484630, rs10499190, rs6569943, rs7743107, rs9321460, rs6935311, rs958747, rs962190, rs10484496, rs7757915, rs6905874, rs7751818, rs927330, rs9389405, rs17723608, rs6922031, rs9494711, rs9321711, rs3924016, rs2080112, rs10484819, rs10499212, rs10499213, rs10484810, rs1452989, rs966996, rs9399359, rs1932189, rs961938, rs12206385, rs17071147, rs17071153, rs7743862, rs9791312, rs198669, rs4896601, rs6570534, rs12194883, rs2179409, rs17073506, rs2473138, rs7744950, rs960335, rs543638, rs1972364, rs1970317, rs472577, rs6904516, rs9322102, rs9403988, rs11962206, rs9485394, rs7452369, rs10046456, rs9322290, rs712209, rs2295084, rs12210297, rs3020348, rs6916835, rs9371557, rs3853250, rs1884052, rs722208, rs3798573, rs2813563, rs6940741, rs575649, rs9285536, rs1712, rs9322407, rs7768164, rs10499270, rs1281971, rs1281967, rs4869783, rs317089, rs524731, rs617648, rs10485356, rs10485357, rs4869843, rs6930662, rs170843, rs721101, rs2073012, rs4128674, rs10499297, rs10499295, rs7773053, rs921298, rs6922110, rs10499283, rs10499282, rs10485201, rs1885625, rs9322596, rs4386836, rs4128492, rs1394887, rs1505561, rs589588, rs168455, rs11963688, rs2273070, rs9346973, rs9458974, rs9459141, rs7774394, rs2502618, rs6920842, rs585078, rs2235824, rs2016588,

rs9295089, rs169858, rs2485367, rs294884, rs1394235, rs4709294, rs1890581, rs240854, rs406228, rs16890597, rs1853748, rs1158619, rs6901166, rs622342, rs2144723, rs2465836, rs1782634, rs1488, rs9458141, rs9456641, rs3798940, rs6920768, rs9295148, rs12191995, rs6936525, rs9458419, rs6455790, rs1893895, rs1954926, rs713055, rs951196, rs2000753, rs732434, rs12192200, rs6455821, rs2205624, rs2056907, rs9355431, rs9347780, rs1874403, rs2063428, rs979515, rs2758936, rs559156, rs495725, rs220793, rs697491, rs777191, rs1445288, rs1998167, rs2235280, rs6934309, rs3799594, rs3799570, rs963302, rs6928848, rs845671, rs2749257, rs10484535, rs2342646, rs599957, rs9455701, rs716292, rs7764680, rs6928867, rs17182135, rs1998041, rs9455845, rs10485331, rs911839, rs9295002, rs9295018, rs2011670, rs725239, rs10484503, rs9295396, rs2103816, rs6456222, rs9460029, rs2076319, rs2206285, rs12666071, rs9642256, rs11764261, rs4075778, rs10499317, rs2251235, rs2895215, rs9648148, rs10234557, rs10275045, rs10244946, rs1403174, rs951694, rs1637750, rs1002170, rs10488611, rs10488610, rs809547, rs798528, rs2258960, rs11765726, rs1182175, rs7783400, rs6948739, rs17132849, rs10248838, rs7793634, rs10242793, rs10951005, rs11773639, rs7801254, rs9771086, rs6965800, rs7803625, rs10267496, rs955194, rs17135035, rs10261971, rs17135109, rs7341401, rs17187114, rs17322650, rs7793374, rs10486158, rs10237013, rs10278724, rs37965, rs6960154, rs3823820, rs293185, rs293136, rs12699238, rs7803002, rs847992, rs12699560, rs9792016, rs7808321, rs7800171, rs10499450, rs10499453, rs10254418, rs1464822, rs10499461, rs10242014, rs4448156, rs1540880, rs10499515, rs1178363, rs1178328, rs2529749, rs587325, rs2240279, rs2905456, rs994823, rs10486333, rs1541357, rs11975573, rs1730922, rs6945209, rs1815976, rs7779545, rs10499557, rs2961296, rs208543, rs10486407, rs87, rs886836, rs10486410, rs10486417, rs286698, rs4722534, rs4719839, rs38517, rs7778639, rs744500, rs17156863, rs917275, rs16874676, rs1955083, rs17810895, rs10499587, rs929359, rs10488084, rs10488086, rs2893363, rs10259972, rs9639615, rs1558068, rs38410, rs10951293, rs7780078, rs10487734, rs7785412, rs10487739, rs722271, rs30586, rs715455, rs10486500, rs1349401, rs1580019, rs4636106, rs2392209, rs10486512, rs4723261, rs10486615, rs10486616, rs10486622, rs7802225, rs1365889, rs7789889, rs1592418, rs987479, rs10486659, rs329244, rs1425143, rs343039, rs10242913, rs2718007, rs6952488, rs10488028, rs7785477, rs2541086, rs1420426, rs2287126, rs9655380, rs1986567, rs1882074, rs1524075, rs1717746, rs1113136, rs2037602, rs757906, rs10267118, rs29696, rs1013789, rs2108179, rs10486730, rs846301, rs846329, rs846319, rs2116648,

rs1917213, rs1524594, rs952890, rs10499629, rs7809051, rs611546, rs10486744, rs2288354, rs590246, rs4724155, rs1006108, rs6957566, rs12112386, rs10486737, rs6972794, rs886552, rs11772689, rs10487680, rs10232587, rs6957651, rs217377, rs740094, rs3735478, rs3735481, rs1011874, rs17172636, rs7781943, rs12702227, rs740098, rs17172713, rs41516647, rs856563, rs6944447, rs10487776, rs10250146, rs7792919, rs2728489, rs834608, rs953264, rs2348460, rs10499669, rs2348669, rs17132044, rs17547209, rs9639018, rs17712043, rs717707, rs10499681, rs1030708, rs10499682, rs885685, rs6583479, rs993873, rs10485949, rs12718166, rs10485944, rs10240495, rs6955728, rs1905272, rs2124803, rs10245556, rs7805656, rs1456893, rs10261822, rs10499695, rs956117, rs2190501, rs6963498, rs6943901, rs2189817, rs10486746, rs1074571, rs10486749, rs10248051, rs10488355, rs10499698, rs1917286, rs4947617, rs6967900, rs10243862, rs6592947, rs736248, rs665087, rs10488565, rs10488563, rs4292640, rs10488561, rs10488559, rs7776883, rs2191715, rs2006709, rs2041562, rs10488331, rs10488329, rs2215660, rs956089, rs10215607, rs1661605, rs2330177, rs1230521, rs2913022, rs7806295, rs1357963, rs10224754, rs6593078, rs7786939, rs10488322, rs6973726, rs7777919, rs2098460, rs2042539, rs17622602, rs2113757, rs6593093, rs10267614, rs17135947, rs7799773, rs17669013, rs12536631, rs10499719, rs1405424, rs956316, rs6954302, rs1965518, rs6946553, rs4245562, rs12536678, rs10259525, rs10499738, rs472724, rs480777, rs964823, rs331827, rs7788137, rs7806148, rs10216072, rs2709322, rs4947480, rs881055, rs2067536, rs763317, rs4140770, rs17172446, rs6593211, rs17172458, rs6943149, rs6958884, rs10499755, rs4948044, rs10245396, rs4948073, rs11981883, rs872294, rs2304376, rs816417, rs698650, rs1387068, rs10499762, rs2634083, rs10499764, rs4870653, rs10499766, rs6976658, rs12539799, rs2966455, rs4870626, rs4870684, rs10256786, rs10232967, rs10866816, rs12669739, rs6974091, rs1842999, rs11249871, rs8188441, rs9719005, rs2382591, rs10240351, rs4310100, rs2119448, rs1583872, rs2119445, rs1595989, rs1579723, rs1533823, rs6956675, rs6965334, rs4585626, rs3923004, rs2871906, rs17174613, rs7797441, rs1153014, rs9654806, rs3751565, rs12112450, rs10949856, rs6954679, rs7783518, rs4717979, rs10499770, rs13241939, rs17139313, rs2199662, rs6955211, rs11764842, rs11981820, rs1608900, rs4718112, rs6460190, rs41474947, rs13229816, rs4718222, rs887715, rs41464249, rs2714613, rs2530433, rs12669859, rs4527771, rs7796950, rs7782732, rs4718769, rs10230101, rs10224955, rs10486869, rs719114, rs1859530, rs10266886, rs17141924, rs6957958, rs10486861, rs6958850, rs6460557, rs1881014, rs1464848, rs10272163, rs17142989, rs1950148,

rs4129606, rs1404955, rs2079961, rs1203458, rs2270209, rs10243317, rs10487618, rs10487619, rs844699, rs6955049, rs844762, rs4577845, rs10486883, rs4719222, rs2944839, rs2944825, rs2860506, rs956422, rs2074755, rs2286257, rs2240134, rs17148570, rs10488497, rs17720563, rs7810561, rs10499833, rs1582304, rs10237942, rs17156247, rs10499835, rs10488040, rs1544459, rs848481, rs6466236, rs7804616, rs727200, rs2627539, rs17154933, rs10485966, rs10485970, rs10486940, rs7341478, rs258716, rs42237, rs17286384, rs6977205, rs17148193, rs17217554, rs302101, rs17157992, rs10954734, rs12536761, rs1346686, rs10499885, rs1403786, rs10499889, rs2372910, rs4386910, rs3810885, rs6943724, rs802062, rs31651, rs10239908, rs1688886, rs2282948, rs2282952, rs12539024, rs2299199, rs17150307, rs10243541, rs10486888, rs1859425, rs10486894, rs10486895, rs10486902, rs2214339, rs719372, rs10274783, rs1468136, rs17476298, rs10224911, rs2041349, rs2724355, rs4316081, rs34899057, rs404, rs11766251, rs723668, rs10488535, rs10488537, rs10488538, rs10243420, rs10488544, rs1541433, rs2528530, rs2528552, rs10487230, rs7779653, rs2106299, rs2677056, rs10252856, rs10244480, rs854730, rs2214082, rs17166735, rs705382, rs10953143, rs7785039, rs7778623, rs2106511, rs340, rs854075, rs1227519, rs940424, rs1922335, rs319333, rs42064, rs7806412, rs10486030, rs10486029, rs2158329, rs9656040, rs10261833, rs1375670, rs10486860, rs1207731, rs10499934, rs1405860, rs953686, rs10485998, rs2394717, rs4729368, rs41375946, rs12537233, rs4729690, rs6943474, rs6963365, rs10252737, rs3987966, rs11981980, rs2411081, rs10486852, rs2109697, rs2017179, rs3808024, rs720078, rs10435337, rs2299379, rs634500, rs2384982, rs4729959, rs2385173, rs2193204, rs4727605, rs4338031, rs10447822, rs997980, rs7806955, rs2395911, rs2269778, rs3847084, rs2237682, rs4564, rs10953569, rs7792321, rs211793, rs396911, rs1508183, rs12705695, rs1508203, rs1404917, rs956407, rs4376443, rs4730462, rs10500002, rs1525804, rs10953726, rs6947946, rs13240515, rs10500024, rs4730593, rs1548395, rs10500036, rs10500037, rs1901186, rs10500038, rs10486026, rs6466487, rs10486023, rs1229762, rs650512, rs6961343, rs10487154, rs6973150, rs2709474, rs6973168, rs12706029, rs10267100, rs6956440, rs7790613, rs12672066, rs2401958, rs1986912, rs12706043, rs10282130, rs10255641, rs11764997, rs17138391, rs2157799, rs1918923, rs10228039, rs7795356, rs714180, rs2299436, rs41775, rs10487355, rs3864652, rs17139387, rs718737, rs39311, rs1896887, rs2188150, rs1429568, rs4730795, rs6971495, rs10487377, rs2402267, rs10487382, rs2215628, rs4370471, rs10279382, rs2251761, rs10487754, rs17144752, rs13232111, rs17683741, rs1204014, rs10500089,

rs10487980, rs10246506, rs10487974, rs10487971, rs723444, rs10500100, rs662165, rs607260, rs10500106, rs1526411, rs10239010, rs2022072, rs1419449, rs953016, rs2188187, rs2299539, rs10487472, rs6960826, rs10487478, rs10487482, rs10954158, rs954007, rs6976221, rs4731420, rs10954174, rs4731441, rs6467173, rs4469397, rs1464972, rs1544705, rs7776820, rs17164992, rs12113044, rs3909553, rs17133193, rs4593472, rs1643263, rs998827, rs7808136, rs718870, rs12707223, rs1562028, rs2349193, rs322220, rs10488401, rs834767, rs10270360, rs4142167, rs10271343, rs1986722, rs1115781, rs1424574, rs889934, rs1424543, rs324582, rs832997, rs1725021, rs322236, rs270895, rs7457119, rs1424372, rs3800652, rs2009990, rs3778819, rs3800672, rs10228244, rs10227148, rs6977910, rs2297240, rs2288071, rs12667471, rs2293177, rs17170146, rs10268498, rs7786717, rs10952611, rs10487514, rs996343, rs12535047, rs369723, rs2172722, rs10487921, rs10487920, rs10487919, rs10487918, rs4537227, rs10500168, rs1880317, rs1024676, rs2372810, rs903900, rs1496541, rs6943628, rs10500174, rs2204412, rs10952685, rs4726875, rs6944301, rs10488347, rs2373690, rs952827, rs952642, rs1558479, rs1006581, rs2303928, rs768403, rs7812088, rs13239239, rs7801616, rs11981567, rs4530949, rs10280781, rs12703305, rs7807331, rs3778738, rs306293, rs10264222, rs765588, rs7803500, rs2158813, rs288749, rs2007015, rs10265650, rs724410, rs10487557, rs2365273, rs2365281, rs10488069, rs737982, rs2365509, rs7793618, rs2024265, rs3802129, rs6943921, rs221289, rs1733133, rs2141739, rs877279, rs2336802, rs262144, rs2730257, rs6459928, rs427231, rs6975106, rs428495, rs6948121, rs1126338, rs7808791, rs2178820, rs2906360, rs10503145, rs10488370, rs1542221, rs10503146, rs1075035, rs906892, rs1703946, rs10503149, rs6985628, rs17754389, rs1019023, rs733597, rs1468416, rs2214861, rs17064201, rs4379476, rs2977186, rs1542067, rs13258860, rs4875793, rs2930379, rs2554728, rs2688388, rs10503226, rs10503331, rs2725653, rs1635627, rs1512804, rs2738159, rs712276, rs2945886, rs9987311, rs2929470, rs17656431, rs7006947, rs7018002, rs10503380, rs998019, rs10503396, rs10503398, rs10503400, rs814359, rs1478900, rs17814360, rs4831795, rs4831817, rs6530637, rs17120202, rs2256311, rs11203672, rs2115697, rs1464997, rs7009933, rs17123148, rs4461937, rs1816422, rs1541933, rs916552, rs2012328, rs2898455, rs6586725, rs10503612, rs10503614, rs2410561, rs958891, rs2029832, rs17126870, rs1441771, rs261, rs2410616, rs17489268, rs7017244, rs10503680, rs4244463, rs9325872, rs1376013, rs2260614, rs10503690, rs7018332, rs2410675, rs10217040, rs4445224, rs4455836, rs2280832, rs10503725, rs1355600, rs218872, rs10099040,

rs1436147, rs819188, rs1631550, rs7007223, rs3106317, rs7819362, rs10503764, rs9331926, rs568610, rs11780263, rs6989077, rs1563940, rs11993943, rs2279445, rs1463362, rs10503851, rs480951, rs10503840, rs11989668, rs10111941, rs13254365, rs17628307, rs1599676, rs10503929, rs9297197, rs10503931, rs4486154, rs6995454, rs10503948, rs4733171, rs10503951, rs7462610, rs4612298, rs7463344, rs10503956, rs2729985, rs716225, rs10503970, rs10503988, rs2703872, rs10503989, rs7816204, rs4739323, rs4739326, rs10503994, rs16885501, rs2067886, rs6468383, rs933115, rs10503999, rs581187, rs6995379, rs4733946, rs1471009, rs6998357, rs4733963, rs9657175, rs7830439, rs1455362, rs1378417, rs10504020, rs10504044, rs10504047, rs10504048, rs997437, rs4131874, rs10504050, rs3136748, rs3136791, rs6773, rs7813173, rs10504060, rs10504061, rs7830743, rs10504062, rs10504063, rs955467, rs11786138, rs10504064, rs10110839, rs6991400, rs16937605, rs10504065, rs6471945, rs11990662, rs1467089, rs341817, rs1606133, rs1509088, rs1458574, rs1598951, rs2956830, rs10092696, rs1219680, rs10435583, rs16916405, rs16916660, rs11990522, rs7816661, rs10504130, rs890328, rs2360281, rs17252559, rs7018154, rs10504283, rs10504284, rs10504285, rs10504288, rs10504294, rs10504296, rs1626773, rs16925594, rs6995588, rs2030378, rs1520273, rs16926421, rs4500113, rs6984890, rs12545275, rs2978513, rs16927138, rs4739003, rs4524781, rs899676, rs10504357, rs1367807, rs720864, rs1217091, rs1402381, rs7013560, rs9886369, rs41343545, rs7001138, rs4308714, rs6472266, rs1138476, rs10105795, rs2553664, rs6472357, rs7824298, rs11994968, rs1517114, rs16936670, rs4364664, rs3763523, rs2977984, rs17689776, rs10105141, rs16937300, rs11784872, rs4434651, rs11989499, rs13274765, rs3735942, rs2701455, rs10504531, rs276650, rs1991644, rs830490, rs41425545, rs2980221, rs10504622, rs10504626, rs10504628, rs10504630, rs10504636, rs4143529, rs10504643, rs2626349, rs723086, rs16939476, rs11992049, rs7833808, rs10087223, rs11998154, rs10109106, rs7462026, rs4739744, rs1382611, rs10958135, rs7823907, rs785965, rs952017, rs921145, rs7004770, rs1374609, rs10504786, rs12548900, rs4132243, rs16912774, rs1496531, rs16914040, rs6997845, rs16895942, rs4961068, rs12056435, rs4584126, rs7018101, rs1996638, rs472039, rs1431564, rs6992217, rs4492337, rs10504946, rs2055052, rs10504942, rs3133724, rs7836535, rs9297966, rs9297261, rs10504957, rs1421222, rs532398, rs6994748, rs10282845, rs2438225, rs13252978, rs7812789, rs10504987, rs3134170, rs1979115, rs10505042, rs827584, rs3098230, rs10505043, rs10505045, rs1116623, rs2511587, rs10505058, rs10505059, rs10505062, rs2959028, rs1383589, rs16874487, rs2920090,

rs2920067, rs2000481, rs981735, rs16880151, rs7832016, rs6994689, rs7844769, rs755136, rs7827891, rs4734218, rs16880299, rs16880319, rs921382, rs2350884, rs1949756, rs10505144, rs7008289, rs10505145, rs10505147, rs9297451, rs988647, rs1904371, rs4876877, rs1912509, rs10505163, rs10505164, rs320528, rs10505171, rs4263796, rs10505191, rs4876294, rs16892637, rs11778755, rs10095641, rs720406, rs7828293, rs10505232, rs10505240, rs10505246, rs953578, rs16887028, rs16887184, rs1401436, rs4145787, rs1356642, rs16887282, rs702770, rs4876620, rs16887929, rs5021979, rs799850, rs799864, rs10505279, rs1918715, rs2316692, rs4129295, rs1550162, rs1898287, rs4129066, rs10505288, rs13281298, rs2036241, rs2635123, rs987087, rs1508566, rs2451160, rs10505328, rs10505329, rs10505330, rs2451171, rs10505334, rs4876853, rs10505338, rs1353171, rs4130891, rs10505344, rs11573870, rs16893258, rs6469994, rs1394426, rs10505396, rs10505397, rs10505399, rs10505400, rs1565033, rs7846624, rs10505402, rs6980813, rs9297663, rs998358, rs10505426, rs7812931, rs4871345, rs10505431, rs2385167, rs4458896, rs7844497, rs16893118, rs41524549, rs1487237, rs10505509, rs759944, rs6990893, rs837224, rs921693, rs16904220, rs16904230, rs3829032, rs7461848, rs13278912, rs930896, rs2673588, rs2553600, rs2553593, rs16904954, rs6471156, rs6471212, rs9657442, rs4472559, rs7812588, rs12679411, rs4552942, rs2610108, rs2649129, rs13282991, rs10505678, rs6991509, rs1949141, rs9324463, rs2705302, rs2705278, rs10505687, rs12674545, rs9324496, rs5019355, rs12155960, rs4736221, rs2318346, rs1395316, rs2873891, rs10505707, rs10505709, rs10505711, rs10505712, rs2045856, rs2467193, rs1008055, rs4484675, rs4380912, rs4736080, rs2261824, rs747132, rs199214, rs1397381, rs6578184, rs307401, rs935461, rs4130074, rs3923878, rs11990344, rs6583636, rs2082801, rs2717594, rs9004, rs2722487, rs1209857, rs2976464, rs2975282, rs7011719, rs13279170, rs2811026, rs16921804, rs7028352, rs10491692, rs10733508, rs10491600, rs10491597, rs16921577, rs10491591, rs749427, rs1885775, rs166788, rs867622, rs10809101, rs10733226, rs10511426, rs10491874, rs7875774, rs10961305, rs10491697, rs7044370, rs942399, rs2376218, rs4741690, rs7020186, rs962606, rs577299, rs10511447, rs4008948, rs10511449, rs7035633, rs1360433, rs1455177, rs1445336, rs572491, rs10491899, rs4741905, rs16921510, rs301468, rs2146040, rs2224572, rs2181146, rs1331380, rs1094328, rs10975417, rs343493, rs340913, rs996029, rs16924243, rs7041863, rs6477071, rs401733, rs2773502, rs7872937, rs1658957, rs4537355, rs818889, rs1407856, rs2148347, rs10976262, rs2930735, rs328851, rs16926594, rs2381665, rs10511487, rs10491571, rs10491572, rs10514819,

rs1416589, rs1768571, rs1344183, rs4084051, rs995336, rs10511491, rs10511494, rs1323591, rs2296101, rs10511502, rs10511504, rs1337808, rs1434262, rs2033554, rs10511507, rs10511519, rs1331660, rs324481, rs557369, rs9299087, rs10511521, rs4742577, rs1412887, rs2802280, rs1333107, rs867980, rs1332203, rs1412398, rs1323802, rs1570591, rs10491918, rs10978082, rs10491911, rs1343535, rs1238877, rs440764, rs16925807, rs1535661, rs7023488, rs10511557, rs954492, rs2183381, rs10959437, rs1591240, rs2151667, rs10511560, rs1577120, rs1889340, rs1931382, rs2200787, rs1931391, rs10118338, rs1580540, rs2130125, rs10491953, rs4297124, rs1446262, rs1416572, rs7859262, rs6474694, rs10511572, rs950850, rs12348188, rs962298, rs995263, rs1590485, rs2762462, rs1086377, rs10511575, rs1331673, rs1185261, rs725741, rs17190837, rs10491750, rs10491752, rs8192981, rs1590405, rs16930854, rs726353, rs1359847, rs10511584, rs7869774, rs512477, rs10125346, rs6474827, rs10491777, rs1108676, rs7875762, rs10491773, rs10491772, rs10511594, rs7865184, rs2131882, rs10511597, rs923918, rs2818939, rs10511603, rs10511608, rs1590349, rs612183, rs10511609, rs7867510, rs2804996, rs2382529, rs16933320, rs12336509, rs811282, rs451878, rs1396705, rs1417974, rs7019851, rs1341737, rs1891212, rs1536687, rs3008746, rs10511612, rs10511613, rs10511614, rs1108491, rs1029081, rs1360548, rs1105208, rs3885908, rs4075177, rs1927625, rs7863925, rs1927628, rs1927626, rs1003069, rs10511625, rs5015540, rs10810681, rs10962747, rs263631, rs427659, rs10511633, rs2197154, rs10511634, rs7851369, rs7025690, rs1467546, rs3780231, rs10491540, rs2209432, rs10511639, rs1343844, rs884098, rs7856201, rs10511650, rs1411248, rs1892917, rs2819206, rs10511643, rs9298791, rs1340044, rs10810961, rs1329726, rs1832746, rs10511660, rs1999489, rs1412672, rs530120, rs7862903, rs2082580, rs10811058, rs945444, rs10511668, rs10511669, rs2229536, rs4977501, rs2451653, rs2175379, rs10511672, rs2772407, rs10123805, rs10964136, rs1887489, rs7862398, rs10514826, rs7870850, rs999399, rs10514825, rs2148791, rs1327398, rs755108, rs2000309, rs12057044, rs10511676, rs2184198, rs1889246, rs403468, rs4977408, rs7851959, rs7858673, rs7042746, rs1111766, rs668703, rs7019271, rs7859334, rs10511689, rs7851363, rs2039390, rs10511691, rs6475483, rs2383162, rs6475490, rs10964771, rs2275883, rs10511695, rs10964882, rs2015345, rs10964938, rs10811523, rs1330314, rs10122473, rs667214, rs16938373, rs16938360, rs10491567, rs991793, rs1351077, rs12115422, rs16938493, rs6475567, rs10757257, rs7039105, rs7865071, rs10811638, rs4382559, rs3731232, rs4074785, rs3731213, rs3731201, rs3731194, rs2811710, rs7044859, rs10965212, rs662463,

rs10120688, rs10965228, rs1333042, rs4977772, rs10511702, rs10965404, rs7872081, rs7857348, rs10511719, rs10511711, rs2789476, rs1339182, rs10511720, rs9298846, rs10511721, rs2210292, rs1111767, rs274915, rs274956, rs6475747, rs10965969, rs10811985, rs896085, rs2218805, rs7032113, rs10115719, rs10217373, rs7852216, rs17254830, rs7044136, rs17771607, rs7036633, rs10117626, rs7039851, rs1984582, rs10812056, rs10491830, rs4977950, rs10511745, rs1041178, rs1318995, rs12238740, rs17773648, rs10511754, rs1106840, rs1318664, rs1758726, rs1576033, rs13301991, rs10511762, rs1128957, rs4978011, rs10491876, rs1231355, rs2383548, rs1220052, rs1023974, rs1219935, rs541805, rs7859385, rs10511768, rs934523, rs629448, rs589411, rs1414925, rs434468, rs10511772, rs16910463, rs2383698, rs2383700, rs10511784, rs1434492, rs10511781, rs2383713, rs10511797, rs10511798, rs10511802, rs655880, rs4878454, rs2783011, rs590299, rs10511813, rs944183, rs951970, rs12000381, rs7020001, rs7018499, rs10968251, rs10491826, rs10511820, rs10511823, rs10812745, rs981864, rs953924, rs10491897, rs10491893, rs2183829, rs10968623, rs1949664, rs939697, rs1438472, rs10491619, rs2383778, rs824257, rs1389728, rs10491627, rs11998784, rs10491645, rs10491656, rs10491657, rs10491658, rs10491659, rs10491660, rs10491665, rs1324608, rs7872330, rs10813115, rs621809, rs10969401, rs9406932, rs4242678, rs7029617, rs10511841, rs2884927, rs1633501, rs7873396, rs10511847, rs3853264, rs10511860, rs6476200, rs3844512, rs3853276, rs2151271, rs7858279, rs17178103, rs1361917, rs10511862, rs3914504, rs16916281, rs10969893, rs7868409, rs7857535, rs10511872, rs10511873, rs16916466, rs10511874, rs1041680, rs10511876, rs10511879, rs3900585, rs727293, rs10970372, rs2026978, rs2375601, rs780754, rs10511888, rs7024321, rs16917512, rs441091, rs10511891, rs10813717, rs1411870, rs1112019, rs1411866, rs10511903, rs597131, rs671018, rs10971037, rs750969, rs10813853, rs1329009, rs4879613, rs2031675, rs2119823, rs10511912, rs10971256, rs4879658, rs10511909, rs9298950, rs10511908, rs10491617, rs1856190, rs10491618, rs855451, rs855438, rs862979, rs855554, rs706138, rs216353, rs912732, rs1785512, rs10511914, rs10511916, rs4319185, rs10511918, rs10972129, rs10511917, rs16931582, rs16931802, rs183239, rs277583, rs13290746, rs2252749, rs2074549, rs1930359, rs7851161, rs3780727, rs10972434, rs9987526, rs10511923, rs10758315, rs869487, rs10972540, rs1885373, rs10491555, rs6476493, rs6476508, rs7035468, rs7847459, rs2381412, rs10972865, rs10972875, rs10511928, rs41449047, rs7865090, rs16933342, rs12346671, rs10511931, rs10511932, rs9298971, rs10511934, rs17391491, rs3824342, rs1888018, rs1010194, rs1411064, rs7023441, rs10814520,

rs10814529, rs309455, rs7045332, rs10814588, rs4878192, rs7862494, rs4400475, rs10814706, rs4440700, rs10511949, rs10973939, rs10758522, rs1758386, rs10974141, rs9407154, rs3119287, rs2500696, rs7858200, rs2321345, rs10907668, rs3007557, rs3007456, rs2874557, rs11263386, rs10115274, rs11263422, rs11263287, rs35882728, rs7848562, rs2217821, rs11262013, rs10908850, rs11262292, rs11262473, rs11265739, rs4308847, rs7041252, rs10118213, rs1810554, rs10908094, rs4111290, rs11141314, rs1887889, rs10511957, rs424970, rs10511959, rs4744668, rs953644, rs12552784, rs11143602, rs1537885, rs10511963, rs10511962, rs3763607, rs1056266, rs12551921, rs10511960, rs998215, rs1045632, rs2309425, rs11145746, rs7868867, rs6559488, rs7870154, rs1331977, rs10481751, rs6559643, rs888601, rs12341262, rs11139997, rs9314727, rs10511972, rs10511980, rs11142465, rs17055851, rs4493964, rs962001, rs509603, rs541326, rs662975, rs1329766, rs2134861, rs716387, rs1367629, rs1857068, rs10512003, rs12552056, rs2795114, rs378941, rs10512022, rs156764, rs10512027, rs2375759, rs10781180, rs2376972, rs518417, rs7039981, rs10512051, rs1340503, rs10521467, rs10512058, rs10512056, rs1888025, rs6560578, rs10521477, rs2022443, rs10491843, rs1934728, rs716080, rs7857901, rs7028509, rs1027765, rs4077632, rs234791, rs722642, rs9314675, rs1341086, rs1873738, rs2769965, rs10512085, rs10512087, rs10512089, rs10491785, rs2027005, rs971259, rs7851908, rs1572148, rs10491946, rs2378482, rs2082708, rs2149341, rs1410550, rs10512110, rs10491944, rs17084413, rs4877199, rs7853963, rs10512114, rs10512116, rs1329387, rs10514830, rs4385545, rs4146960, rs6559697, rs1323763, rs10512138, rs9314735, rs10512157, rs4877892, rs1948308, rs534196, rs665889, rs10512164, rs10512166, rs895606, rs3849873, rs7049108, rs10512169, rs10512173, rs10512176, rs1331444, rs732973, rs10491605, rs1328175, rs10512177, rs10512178, rs9285055, rs2814829, rs6560086, rs10512194, rs7047627, rs10511956, rs11265836, rs721833, rs528191, rs997759, rs1412128, rs951018, rs874977, rs1343100, rs1889205, rs883922, rs2386533, rs17450776, rs10512200, rs1338381, rs528454, rs4744000, rs1360470, rs2126054, rs1172918, rs2780711, rs1172991, rs10993693, rs167078, rs2991215, rs10512203, rs1675305, rs1585459, rs4744064, rs10512218, rs1121979, rs1980848, rs10491805, rs10491804, rs1810687, rs10512222, rs3001450, rs9409699, rs10739959, rs10761288, rs7852292, rs10512236, rs10512252, rs3802458, rs10514835, rs356666, rs10512249, rs4742763, rs589458, rs3824492, rs963150, rs10512244, rs10512243, rs4743556, rs10512241, rs10512240, rs10512239, rs10512237, rs10759417, rs16918797, rs12378350, rs10512254, rs7357631, rs1588636, rs973473, rs7033315, rs7040232,

rs10760120, rs41409644, rs16918167, rs186630, rs7029604, rs1360260, rs10989207, rs10512291, rs4742834, rs2795379, rs2756916, rs1418237, rs7857876, rs10512295, rs10521062, rs1924001, rs7048350, rs718857, rs515821, rs2149816, rs10512325, rs7872034, rs966390, rs1507508, rs10512324, rs4743707, rs1425567, rs2274871, rs3818688, rs10512334, rs10512335, rs995653, rs41393944, rs16924597, rs10739214, rs2417654, rs2417661, rs10521075, rs973915, rs1110960, rs2222133, rs1489666, rs10512345, rs817844, rs1538985, rs10512381, rs2104759, rs10512378, rs10512377, rs10521087, rs1554279, rs10512370, rs10512368, rs10512366, rs7042864, rs10512365, rs593924, rs10512361, rs1323374, rs1407846, rs1188242, rs589105, rs10512360, rs1953054, rs10512356, rs7034647, rs7872727, rs947196, rs2275635, rs2417959, rs10979650, rs1333344, rs10512391, rs7027512, rs6477689, rs1982226, rs10512228, rs10512393, rs881660, rs1407392, rs3902539, rs1590718, rs545955, rs7847333, rs41506255, rs1000115, rs2282181, rs10512410, rs7038720, rs9299199, rs7020283, rs10491726, rs3818295, rs16916245, rs10491725, rs945849, rs823638, rs667463, rs1813202, rs1037182, rs718834, rs814683, rs1408113, rs2418264, rs1490741, rs2636864, rs16928312, rs1249724, rs10513245, rs10739415, rs10513247, rs11787667, rs10513248, rs1073292, rs982463, rs998743, rs1450194, rs10513270, rs10513271, rs2418444, rs3747831, rs1118059, rs7856625, rs2900131, rs1596101, rs803925, rs4837863, rs1113793, rs7850478, rs10491854, rs10491852, rs10491851, rs10513308, rs1927921, rs2048741, rs10513316, rs2809397, rs2722869, rs12684036, rs2806093, rs2809381, rs2809393, rs2806117, rs2769187, rs10513326, rs4836716, rs1418505, rs7037164, rs7860560, rs10513341, rs10513343, rs2274157, rs1221139, rs1359358, rs9299266, rs7031873, rs1468719, rs2416758, rs954214, rs2416804, rs1035029, rs9299273, rs2057471, rs4836897, rs10513408, rs7044945, rs6478571, rs2416894, rs16912237, rs7024546, rs667057, rs591883, rs631086, rs700059, rs803717, rs7874087, rs1888027, rs6478626, rs7027523, rs12336857, rs7022212, rs1857393, rs10818868, rs656906, rs660534, rs7042608, rs953471, rs1041012, rs2282089, rs10513435, rs6478734, rs1317309, rs569313, rs16928937, rs10491513, rs7044613, rs7875644, rs6478813, rs3814524, rs7019045, rs7875406, rs3003615, rs883335, rs1721643, rs10819541, rs2900277, rs10491512, rs3814544, rs11789529, rs1557123, rs894242, rs2269337, rs7027136, rs915398, rs353533, rs353524, rs967174, rs10512414, rs3765542, rs7047157, rs10512417, rs7467576, rs7026497, rs12340081, rs7025, rs12340860, rs3780825, rs882709, rs10901188, rs306549, rs462791, rs1073123, rs17408598, rs7035308, rs7037915, rs608604, rs509064, rs756820, rs129925,

rs2427995, rs521446, rs1105176, rs964138, rs1891987, rs1891996, rs7043655, rs10512419, rs3884535, rs4842251, rs9410019, rs1412933, rs1165017, rs7035330, rs7034337, rs2077581, rs4979643, rs7023287, rs7389298, rs7859352, rs2278975, rs10867107, rs2914521, rs1820789, rs11252546, rs10904561, rs11250718, rs1105116, rs10736957, rs4488125, rs11252332, rs7077209, rs816627, rs2209625, rs816314, rs2790381, rs11815869, rs12249828, rs10508208, rs10508206, rs4519019, rs11250266, rs3793735, rs10903412, rs17156306, rs4347306, rs4880863, rs10794768, rs10794773, rs11250839, rs2452199, rs10508237, rs7097880, rs11251447, rs10508243, rs10904001, rs518246, rs10508254, rs4881171, rs767385, rs835954, rs705468, rs10508257, rs10508261, rs10508263, rs2279419, rs3750860, rs11599077, rs4339941, rs4881437, rs1858447, rs420336, rs11255061, rs2026612, rs10508335, rs1244471, rs10508338, rs265934, rs1887582, rs877345, rs430753, rs500238, rs10508349, rs1415880, rs7079888, rs2646387, rs2025667, rs11256166, rs10508388, rs1538608, rs10508381, rs1339692, rs12263577, rs4509669, rs10490998, rs11256530, rs6602413, rs10795769, rs10508412, rs10508415, rs2224673, rs10508418, rs1570438, rs10490950, rs7894864, rs1291821, rs2768447, rs4747989, rs10508445, rs2399864, rs10508447, rs963336, rs10508449, rs281846, rs10508451, rs10508453, rs11258186, rs17512962, rs2610814, rs7080831, rs1340137, rs7902512, rs10508504, rs12217463, rs10795455, rs10904930, rs12268826, rs17141450, rs7904112, rs2488114, rs7083373, rs17610159, rs10828545, rs12356676, rs11013850, rs10828616, rs16917281, rs10437417, rs10508586, rs10494869, rs7921915, rs16919556, rs2148299, rs1926204, rs719041, rs11011734, rs10508623, rs10508626, rs10508631, rs10508633, rs1925547, rs1590567, rs3758601, rs6482190, rs4024198, rs2066270, rs1409397, rs1778329, rs997650, rs7078244, rs7074731, rs1417374, rs1579131, rs10508655, rs1398024, rs949636, rs10508659, rs10508663, rs12247225, rs11013778, rs1938044, rs1138000, rs10490899, rs220343, rs10508673, rs10508674, rs2150651, rs1045873, rs2220708, rs902903, rs10508681, rs2807238, rs10508690, rs1094830, rs1760767, rs10508694, rs1361636, rs824588, rs1329253, rs4747530, rs976361, rs1402437, rs10508713, rs1999240, rs7073119, rs1335546, rs10508718, rs10508720, rs1998633, rs7073300, rs7091723, rs3818968, rs651134, rs10490914, rs10490915, rs7901884, rs10508742, rs1014083, rs10490902, rs16930161, rs1041218, rs16930212, rs7097877, rs2478831, rs303426, rs11008501, rs16932398, rs11008512, rs10508766, rs10508767, rs10508769, rs211259, rs1775715, rs10508771, rs1108187, rs708408, rs10508823, rs10508824, rs7073673, rs10508832, rs10508841, rs2796806, rs2384598, rs10508845, rs2151173, rs10508850, rs7098998,

rs7076335, rs10508856, rs1578792, rs1192643, rs10508857, rs1321965, rs7915791, rs4934592, rs9703043, rs10908961, rs1589592, rs10160147, rs11239623, rs11239843, rs2505830, rs4409777, rs9326541, rs210236, rs1255396, rs10490937, rs158391, rs7075936, rs2505895, rs10508868, rs624804, rs17158149, rs9326544, rs2078397, rs788272, rs2185792, rs17432763, rs2082106, rs1879316, rs1856398, rs9326506, rs41422044, rs10508869, rs10508876, rs17155285, rs2154401, rs4948995, rs7091141, rs2040078, rs2999451, rs11204208, rs7074427, rs11599914, rs2943244, rs2663018, rs17009410, rs10508909, rs2244967, rs2466750, rs12269023, rs10508911, rs7912808, rs1917800, rs7072155, rs7898545, rs3810950, rs1917810, rs1258265, rs7100934, rs11101224, rs7904589, rs7921218, rs4935162, rs10994675, rs11597667, rs2247033, rs7091407, rs10508946, rs10508948, rs10508949, rs10508961, rs1937658, rs2226253, rs10508956, rs10508955, rs10508952, rs10509028, rs1073665, rs1900474, rs1900493, rs7908118, rs2050318, rs10509034, rs1413668, rs10509035, rs7084992, rs7069064, rs2893700, rs10509056, rs10509058, rs10509074, rs7098459, rs1876129, rs1505918, rs10509080, rs10509135, rs7919724, rs1904406, rs1871445, rs10509140, rs2393702, rs2279942, rs10509171, rs4746447, rs2393904, rs224053, rs224278, rs10509172, rs949566, rs7920310, rs2893914, rs973577, rs906934, rs10509185, rs1009984, rs10509188, rs10509189, rs10509191, rs10509190, rs10761796, rs2140390, rs10509198, rs884243, rs2924307, rs1786912, rs3858138, rs10509255, rs1471383, rs4514303, rs10762050, rs10822809, rs1948944, rs7085996, rs7902091, rs7921788, rs10509286, rs1904620, rs2394381, rs6480263, rs10509290, rs932656, rs7096385, rs597889, rs542411, rs10509293, rs10509294, rs2033372, rs989485, rs10509320, rs931028, rs1132075, rs2704523, rs3847356, rs2394654, rs10509321, rs16927648, rs10509323, rs946749, rs7083883, rs7900440, rs2456251, rs1323075, rs10824347, rs7090986, rs10509377, rs3740242, rs1080874, rs2395419, rs10491078, rs2588329, rs846604, rs10491077, rs10824456, rs7067683, rs4520538, rs1559990, rs2574690, rs10509397, rs2019080, rs288444, rs1655627, rs6480902, rs997888, rs7914988, rs1866159, rs749821, rs4980075, rs3824720, rs2475643, rs10509413, rs2066167, rs10509414, rs1870141, rs2343527, rs1911445, rs10883706, rs11191280, rs17712988, rs10490935, rs973634, rs1739775, rs17100710, rs10509485, rs7076846, rs10509490, rs2350104, rs7576, rs10509491, rs5029676, rs6585956, rs4933370, rs1912303, rs10509522, rs2356728, rs17105842, rs2949385, rs25435, rs2153828, rs10509527, rs10509531, rs2607839, rs2217224, rs2114829, rs4310527, rs2248101, rs10491066, rs10509407, rs2147287, rs11202449, rs7894717, rs10509409, rs7893652, rs10509410,

rs10509411, rs10887759, rs12569998, rs11202600, rs12357281, rs9783238, rs701848, rs637101, rs7070722, rs2162361, rs10509543, rs3891323, rs10509546, rs2209554, rs7899358, rs814633, rs1888606, rs10509562, rs432950, rs444764, rs418276, rs11202852, rs10509556, rs1147604, rs9420506, rs2801527, rs17382301, rs1556478, rs7074555, rs1120669, rs12414170, rs2418929, rs2148277, rs7902947, rs10509582, rs1274143, rs10509589, rs7900020, rs1329165, rs17130391, rs10458740, rs9325455, rs3910156, rs3816565, rs893586, rs7071503, rs12264143, rs2297960, rs2252200, rs1539468, rs11186926, rs2140553, rs956070, rs11187515, rs10509661, rs4917948, rs2042615, rs4918043, rs4918082, rs2860749, rs7919320, rs4394764, rs1678, rs816278, rs7896133, rs4110517, rs2901822, rs10509679, rs1934975, rs10509685, rs10509694, rs6583995, rs7080061, rs1001875, rs1327559, rs533480, rs943345, rs17458865, rs10509699, rs2446024, rs10509701, rs10491070, rs953097, rs10509713, rs764223, rs1112707, rs872570, rs10509715, rs928577, rs1334461, rs6584171, rs1408943, rs4919185, rs7915743, rs701801, rs6584206, rs1925647, rs10509723, rs500028, rs483952, rs1159006, rs474898, rs1336509, rs7070112, rs1266165, rs9325491, rs10509727, rs10509728, rs1578636, rs10509729, rs4129552, rs2862554, rs12253348, rs495734, rs2273695, rs12769518, rs10509745, rs10509748, rs644633, rs6584424, rs10509750, rs10509757, rs10509763, rs7897663, rs879543, rs10490951, rs9325510, rs805650, rs1265004, rs471247, rs11191942, rs7907367, rs10509769, rs10491046, rs10509770, rs280838, rs2864022, rs10509773, rs4350297, rs4918126, rs2491380, rs7085888, rs3862006, rs867975, rs12359907, rs9971359, rs1417637, rs4917621, rs10509947, rs10509949, rs7085622, rs1923655, rs10509953, rs644420, rs10509954, rs2419600, rs4336963, rs10490988, rs180645, rs7070763, rs2420245, rs758576, rs7100905, rs10787774, rs703424, rs3009922, rs3009929, rs12569630, rs3847496, rs10788072, rs1575915, rs4372362, rs17101435, rs7895870, rs10902895, rs4100700, rs1898458, rs2438123, rs4357644, rs2176138, rs11245061, rs4027454, rs3886847, rs10510143, rs10510145, rs9422897, rs6597725, rs10510149, rs3781001, rs1926147, rs1410062, rs1327560, rs1335009, rs2251104, rs11591969, rs12358786, rs782391, rs10829484, rs559109, rs2039547, rs1886380, rs10491028, rs4750727, rs2039371, rs871029, rs3858300, rs551491, rs1120982, rs4142058, rs4751145, rs7086460, rs7084453, rs900912, rs10491065, rs1655154, rs2136298, rs2005299, rs1122111, rs748265, rs2118637, rs3922590, rs4074863, rs4077516, rs9419659, rs3935000, rs1491192, rs11146353, rs945942, rs2252728, rs1576301, rs10857731, rs2031920, rs8181436, rs3802985, rs4758635, rs7394810, rs7924341, rs4131364, rs6578288,

rs10768947, rs217238, rs2106465, rs1971929, rs63934, rs234873, rs10488671, rs2071114, rs10833326, rs11025773, rs7105143, rs7123164, rs4575303, rs7101445, rs11029779, rs16929738, rs1026231, rs4910584, rs7113845, rs894457, rs7935375, rs2034836, rs11040813, rs10500661, rs1079199, rs10500672, rs1960352, rs1506972, rs2200651, rs4351800, rs10500701, rs10500702, rs1528125, rs3849994, rs1079452, rs16905816, rs1560569, rs1967655, rs11604121, rs12574246, rs41369549, rs10840262, rs10500708, rs10743113, rs4243950, rs389534, rs3763862, rs10500721, rs1372809, rs10500724, rs4444073, rs896043, rs10500725, rs10500728, rs16908086, rs3993279, rs719152, rs10500738, rs10500740, rs10500742, rs4334005, rs1994399, rs10500744, rs4128873, rs4078145, rs7106832, rs2013486, rs4129145, rs10500766, rs10500767, rs10500771, rs10500773, rs10500777, rs307207, rs307253, rs1459011, rs9299927, rs1609339, rs3900595, rs2597199, rs10500805, rs1496162, rs3884537, rs2282653, rs7113987, rs2196961, rs10500819, rs1065024, rs3922559, rs10500822, rs10500823, rs10500827, rs2043736, rs1347677, rs4757391, rs7931794, rs1471980, rs16934376, rs2240491, rs9988866, rs11024717, rs1503501, rs1502976, rs11025280, rs2585768, rs11025346, rs10833331, rs7129522, rs10500908, rs4128394, rs10500910, rs963497, rs7129096, rs10500913, rs1350657, rs2156818, rs10500919, rs1487827, rs428209, rs7933496, rs2468600, rs10500949, rs1381710, rs10500959, rs4922663, rs7926262, rs12292038, rs11027430, rs10500995, rs10500997, rs1031209, rs1365075, rs12271990, rs10501051, rs10501064, rs1450202, rs2122455, rs959044, rs10501071, rs10501078, rs10501080, rs10501082, rs1478690, rs10501084, rs1038101, rs2172225, rs1231600, rs322626, rs1570337, rs4408284, rs1425170, rs489883, rs509774, rs506725, rs3781849, rs8181580, rs4922844, rs768734, rs1806156, rs16922544, rs11822986, rs7941147, rs3751076, rs1048904, rs286873, rs11032839, rs1553761, rs1571134, rs1326941, rs2986429, rs10488801, rs10488805, rs1425806, rs10836893, rs10768344, rs7130373, rs821038, rs326568, rs10501209, rs2945552, rs432248, rs330948, rs1498450, rs4128862, rs769820, rs10501240, rs10501242, rs7102885, rs10837555, rs1462216, rs10501249, rs10501251, rs11036306, rs10501261, rs12295644, rs1900525, rs1354777, rs10501267, rs10501268, rs7944242, rs899033, rs7126881, rs4545541, rs10501275, rs10501276, rs1531932, rs10501277, rs1840741, rs4405294, rs10501279, rs1488616, rs7358511, rs884597, rs10501285, rs2101816, rs10501296, rs10501299, rs10501302, rs1518813, rs178505, rs7108467, rs2013594, rs9300049, rs10082687, rs10501305, rs6485566, rs923312, rs966905, rs3758729, rs10501313, rs2044874, rs901902, rs4755997, rs10501314, rs728516, rs17786364, rs10742764, rs724759, rs9300053,

rs17787136, rs11600112, rs7926314, rs10838551, rs10501317, rs2070852, rs11822959, rs1007738, rs11040226, rs7935661, rs4881692, rs16906441, rs11245629, rs11245639, rs3904271, rs692726, rs1589629, rs1608272, rs1833261, rs4417255, rs8189140, rs1580785, rs1939284, rs17570016, rs483011, rs521874, rs10902354, rs12805992, rs2078611, rs7482339, rs10501342, rs10501343, rs10501344, rs10501347, rs1842692, rs1871848, rs1026866, rs10501349, rs10501350, rs1080800, rs10501358, rs737368, rs1793425, rs1942609, rs540505, rs524288, rs10501363, rs612688, rs2441987, rs1451319, rs11229371, rs17474904, rs10750900, rs10792172, rs11229695, rs476776, rs11229933, rs11600743, rs1879929, rs17153714, rs11229957, rs1042613, rs558788, rs1303617, rs576483, rs11230161, rs632185, rs589688, rs1426247, rs962813, rs11230589, rs683193, rs195157, rs10501391, rs1939768, rs513338, rs4102214, rs4405320, rs483515, rs1207462, rs1783811, rs474707, rs10488702, rs527039, rs10501396, rs507005, rs1787666, rs1151488, rs603645, rs669371, rs528736, rs10488727, rs4930352, rs962297, rs4988300, rs312781, rs11602256, rs2513272, rs3763831, rs4495899, rs4131929, rs559664, rs10501400, rs1463618, rs1112008, rs9736587, rs3867286, rs10501401, rs2087774, rs624765, rs10501403, rs4945013, rs9651754, rs6592326, rs11235093, rs1548348, rs493065, rs12416741, rs17162133, rs4944477, rs6592474, rs163609, rs7950814, rs7123616, rs341066, rs577536, rs4944584, rs341053, rs11235577, rs7936751, rs672660, rs826047, rs10501413, rs10488771, rs3741130, rs10793085, rs1303475, rs7943085, rs10501420, rs537054, rs7952096, rs7106757, rs4456280, rs11236393, rs11236415, rs534179, rs11236683, rs7118970, rs7943913, rs3740765, rs1790246, rs947841, rs1790256, rs1823508, rs7110670, rs7931417, rs10793285, rs579711, rs4945276, rs7128417, rs10793324, rs7936011, rs10501429, rs2051454, rs10899587, rs2463810, rs7104390, rs4118071, rs1917873, rs4945441, rs4387371, rs2514489, rs12361324, rs7924334, rs10501568, rs1940078, rs10501571, rs1943714, rs10501576, rs12787519, rs2212406, rs1346264, rs2386580, rs10501665, rs308815, rs308793, rs3816649, rs17191474, rs1569182, rs10830963, rs11021370, rs600873, rs12800440, rs1939478, rs10734174, rs10501882, rs1482220, rs1073756, rs2435576, rs334265, rs17133310, rs17133326, rs922264, rs10501968, rs577251, rs10501969, rs582691, rs12285135, rs17352054, rs11225385, rs639752, rs3819089, rs601592, rs1944908, rs11226609, rs41443752, rs1938958, rs4363555, rs1939148, rs528205, rs2508467, rs556968, rs1043144, rs7928790, rs1396915, rs1605891, rs1396918, rs17109177, rs17109237, rs17110093, rs1618597, rs226109, rs170486, rs120434, rs7123425, rs10488719, rs10488716, rs10502123,

rs7111960, rs12279296, rs10502124, rs10502125, rs321344, rs574568, rs2518387, rs2853126, rs873411, rs10891403, rs12802504, rs897691, rs1784684, rs238922, rs2250728, rs420234, rs578014, rs10502193, rs10502195, rs4109748, rs1648355, rs491198, rs10502212, rs12419815, rs12293413, rs7117546, rs1984973, rs1440189, rs17119495, rs10502215, rs556727, rs4245167, rs496547, rs4936451, rs673768, rs512703, rs2241646, rs667775, rs4354701, rs1789792, rs10502232, rs7129717, rs10502233, rs3901285, rs2852212, rs11218067, rs477389, rs10502248, rs726601, rs1131497, rs1503420, rs474441, rs1219410, rs10502263, rs511514, rs516415, rs4121693, rs485139, rs17126374, rs500334, rs655283, rs559453, rs1216554, rs1901183, rs964661, rs507800, rs555397, rs1368863, rs10501858, rs2276312, rs618176, rs588974, rs3926407, rs2226935, rs1946052, rs1940007, rs1939990, rs631562, rs1944627, rs1944807, rs2013156, rs985474, rs1528611, rs1560493, rs356242, rs2042599, rs1364772, rs1364780, rs1863372, rs1940751, rs1477577, rs476994, rs1940356, rs535908, rs510628, rs970924, rs618441, rs11221707, rs10488778, rs858696, rs10791112, rs1368850, rs1793823, rs12226862, rs10791130, rs1628402, rs908147, rs931859, rs1857922, rs1527780, rs748807, rs649928, rs560905, rs4572146, rs2163561, rs528190, rs515478, rs10894663, rs2078454, rs3924072, rs4128621, rs11223544, rs11223560, rs715797, rs329669, rs585166, rs639165, rs11223704, rs514417, rs1146195, rs4132239, rs2000862, rs2156707, rs1944872, rs1892988, rs1944892, rs1039778, rs10750585, rs11821080, rs1904226, rs11224201, rs1500095, rs953385, rs11064561, rs9651889, rs4980854, rs797754, rs2286781, rs740890, rs10505718, rs2051852, rs7954090, rs1073939, rs10491954, rs10491955, rs10491956, rs1859390, rs7135327, rs2240506, rs7296858, rs2058112, rs4766415, rs758166, rs763385, rs10491961, rs2429142, rs2370251, rs2238083, rs16929388, rs2041310, rs11062425, rs10848757, rs10082968, rs537136, rs1860392, rs1000823, rs11062643, rs626979, rs11062948, rs10774187, rs2724240, rs7132832, rs10505729, rs929710, rs7961645, rs10492053, rs7299185, rs997868, rs11063326, rs2286580, rs965185, rs10492060, rs2109419, rs10492068, rs1558278, rs7963105, rs11064153, rs7960757, rs999075, rs7975939, rs2110067, rs6486850, rs6486903, rs10505737, rs10505735, rs6487333, rs10505738, rs1000824, rs1805731, rs3026252, rs4882978, rs2889717, rs7964970, rs10492111, rs10772060, rs3176778, rs4418897, rs4764015, rs10845065, rs765790, rs11838144, rs33018, rs7316817, rs1972571, rs10492099, rs11054078, rs10845256, rs7315843, rs1451770, rs2111048, rs4262801, rs2416946, rs7301588, rs6488519, rs10743998, rs3851600, rs10492123, rs10492127, rs1805237,

rs6488611, rs10492131, rs7970144, rs7955617, rs7305447, rs951378, rs10505804, rs1163787, rs7305694, rs10841271, rs4564400, rs2694978, rs2579260, rs1444628, rs1304608, rs3829310, rs10743408, rs964615, rs2900478, rs10505872, rs1860949, rs10492116, rs1871136, rs3782525, rs10505877, rs10505882, rs932055, rs11046525, rs7979865, rs10505888, rs10842074, rs4553417, rs7484363, rs1463438, rs7316738, rs7971353, rs7955257, rs10505932, rs10505934, rs10505936, rs10505937, rs4131756, rs2728842, rs10505938, rs1357250, rs4963750, rs579556, rs4963776, rs10505943, rs10505947, rs10505948, rs11047723, rs17376782, rs12424711, rs7315339, rs4963606, rs11048055, rs10505981, rs10505983, rs853516, rs10505985, rs829830, rs10505991, rs1531649, rs1480039, rs10842853, rs7955286, rs10506018, rs10506019, rs722135, rs306637, rs10843059, rs10506031, rs10506034, rs10506036, rs10506039, rs7296538, rs10506040, rs1512559, rs10506043, rs11050234, rs12307336, rs822875, rs16934426, rs2033028, rs7312849, rs10506052, rs10506056, rs10506059, rs1531949, rs977925, rs7962896, rs2799985, rs16919217, rs1995227, rs10506101, rs2133675, rs10506102, rs721046, rs3910795, rs4129033, rs2387809, rs11181601, rs3908192, rs8189525, rs7312700, rs11182231, rs11831227, rs4002321, rs11182473, rs2387836, rs1843892, rs1825806, rs10506123, rs2730913, rs2653740, rs864324, rs2388059, rs17126850, rs11170782, rs10876547, rs11171127, rs2293810, rs11173862, rs11174115, rs6581439, rs10506140, rs11174609, rs10506142, rs11174732, rs4611275, rs10506143, rs7971218, rs11564215, rs2131081, rs10878356, rs10506153, rs10506160, rs17589334, rs10506164, rs17128301, rs7975790, rs2197356, rs17128396, rs1465072, rs10491999, rs10492000, rs752767, rs1669891, rs1626507, rs10506209, rs2406862, rs1922761, rs4590937, rs10506212, rs1514675, rs1080902, rs4768491, rs1399380, rs10506226, rs10506227, rs2132091, rs10506230, rs1731442, rs1675764, rs10506232, rs10506233, rs10506235, rs10506242, rs10506243, rs10506248, rs10506249, rs10506250, rs10506251, rs1450538, rs11183067, rs11183114, rs4516050, rs3989940, rs2250490, rs727363, rs10506272, rs952968, rs214664, rs215357, rs1233062, rs2189480, rs10492082, rs10492081, rs10506278, rs2450994, rs2087342, rs4760707, rs2731071, rs2071380, rs7980489, rs3741628, rs4132370, rs953673, rs2453481, rs1565933, rs10506283, rs2694841, rs10506285, rs10506286, rs4133070, rs10506287, rs296763, rs17124448, rs2277355, rs10506291, rs7132551, rs11169348, rs17124613, rs7312252, rs4348979, rs10506293, rs7970694, rs7299901, rs6580767, rs10783388, rs10735827, rs11169561, rs10876096, rs11169567, rs829112, rs17124979, rs2230674, rs17291650, rs829125, rs4768924, rs4768925, rs11169578, rs10876099, rs1583697, rs1659375,

rs1362964, rs10876100, rs861204, rs17125002, rs10459239, rs4768937, rs1631348, rs2579072, rs829127, rs829131, rs844175, rs829141, rs829143, rs4768934, rs7957749, rs17125064, rs6580775, rs12830125, rs11169607, rs11169610, rs11514118, rs764606, rs2359006, rs2359005, rs7306330, rs7306441, rs1362965, rs17125088, rs7965566, rs12317171, rs11169625, rs17125111, rs319938, rs319936, rs11169634, rs2046498, rs7978723, rs7978782, rs2228250, rs1586098, rs4761997, rs2271086, rs4761828, rs6580842, rs303817, rs303818, rs6580868, rs10495312, rs949387, rs1573514, rs10506306, rs401926, rs2737309, rs10506329, rs998401, rs10506336, rs11171228, rs10506340, rs11171271, rs10506342, rs7962641, rs7975545, rs3947764, rs3922689, rs10783719, rs12579915, rs4575375, rs3923056, rs10506345, rs3858536, rs772923, rs2066812, rs10450, rs2035081, rs10506349, rs11834021, rs7358723, rs1466535, rs537161, rs1284467, rs2054515, rs1871417, rs1050045, rs12368653, rs8176351, rs2277326, rs10877029, rs1395513, rs17491714, rs10506392, rs982492, rs1032946, rs265595, rs2135639, rs10506391, rs17120463, rs7307220, rs10506382, rs782118, rs10506375, rs3913094, rs1512830, rs10506364, rs1471063, rs10506362, rs17121357, rs2712516, rs17121475, rs10506359, rs10506358, rs2197334, rs10506356, rs907344, rs10506353, rs7952875, rs1500038, rs12308619, rs10877232, rs10506352, rs7975333, rs1996199, rs17122488, rs276070, rs10877300, rs908095, rs17559210, rs4760293, rs17122830, rs11173188, rs9325169, rs17123194, rs903033, rs10506406, rs2364149, rs7300515, rs4619187, rs2723729, rs4758876, rs10877483, rs7305965, rs987985, rs1349795, rs10784238, rs7296247, rs7484716, rs2360681, rs7960162, rs7959668, rs7134845, rs851911, rs17125610, rs11174282, rs1440723, rs10506435, rs17125738, rs10506432, rs11174296, rs11174379, rs7972031, rs10506440, rs12310616, rs2167287, rs716552, rs342155, rs668562, rs10506453, rs772556, rs17098575, rs699619, rs10506470, rs10506458, rs1495028, rs962862, rs10506439, rs7962346, rs1250680, rs722919, rs11174963, rs11175003, rs11609829, rs6581563, rs7303577, rs2141764, rs41391745, rs269804, rs1445441, rs1373877, rs10506531, rs1344945, rs1370941, rs997718, rs10506526, rs10506525, rs11175978, rs1168330, rs10506483, rs17102565, rs10506486, rs10506488, rs7310442, rs17102805, rs716226, rs7958887, rs10506494, rs10506500, rs10506507, rs1252271, rs2174294, rs17247855, rs17836619, rs4471523, rs10506550, rs10506552, rs17103904, rs1731773, rs2700146, rs11176976, rs10878718, rs6581805, rs1038164, rs10506559, rs2701085, rs2013072, rs1152937, rs1144965, rs2870827, rs3922594, rs683713, rs317689, rs7979636, rs221083, rs518634, rs710780, rs710765, rs1373453, rs775450, rs10506570, rs10506571, rs1531302, rs1870419,

rs10506581, rs10506582, rs7967279, rs1495345, rs796845, rs635461, rs11178246, rs10879157, rs1431257, rs10506596, rs17108407, rs2439732, rs4351856, rs11178351, rs2089975, rs10506606, rs11833635, rs7955573, rs10506613, rs7302918, rs10784885, rs7959895, rs983168, rs4760786, rs937322, rs11178647, rs1877120, rs7487664, rs7956954, rs1136025, rs11178806, rs17109757, rs1316998, rs1298467, rs1149000, rs10506639, rs4146372, rs10506655, rs12311646, rs12424413, rs17744331, rs9652041, rs12311315, rs12813018, rs11179583, rs1356198, rs7136447, rs17787103, rs12427058, rs10859738, rs10859789, rs12308978, rs10506793, rs1546590, rs10506802, rs10506804, rs10506806, rs10506807, rs10506813, rs7133394, rs7132962, rs1922404, rs2103393, rs10506846, rs10506853, rs10506854, rs10506856, rs10506902, rs11116201, rs7979024, rs17011669, rs728084, rs2947136, rs1118069, rs10506905, rs10506906, rs2468284, rs2468304, rs10506907, rs7976271, rs1670003, rs10506910, rs10506926, rs2203199, rs17015421, rs11104726, rs2471507, rs2471503, rs2468257, rs2471517, rs17837082, rs7966281, rs4842769, rs10745558, rs4842776, rs11106205, rs11106224, rs17019519, rs10745617, rs10777442, rs17790352, rs1488643, rs10507051, rs10507052, rs1565216, rs10507055, rs11108115, rs7311009, rs2043608, rs2660896, rs1093240, rs10507075, rs10431437, rs10492270, rs2372643, rs10507108, rs4764641, rs7972264, rs11110867, rs7958578, rs2373584, rs1520223, rs1607693, rs4764695, rs10860860, rs7978742, rs10492320, rs35749, rs10507148, rs7306268, rs7976027, rs11111496, rs3751204, rs4964820, rs3829300, rs2700517, rs2722171, rs10507174, rs1704908, rs10507198, rs4600310, rs10507202, rs1345542, rs10507203, rs10507204, rs10507206, rs1362978, rs11113353, rs6606687, rs3825391, rs850511, rs10492013, rs732166, rs3809283, rs7300082, rs7311116, rs7972340, rs627308, rs4767068, rs2056698, rs2106970, rs6489847, rs2891405, rs10492022, rs10492024, rs10492028, rs10492029, rs10507237, rs7966103, rs11615214, rs2195222, rs2114865, rs11067031, rs10507244, rs10774838, rs10507266, rs11067898, rs10507269, rs10507270, rs952417, rs6490059, rs1796018, rs885397, rs1472768, rs10507272, rs16946926, rs748380, rs10507275, rs4767476, rs1051879, rs2062530, rs10507279, rs3887055, rs10507280, rs1580855, rs4767550, rs708857, rs10638, rs1726393, rs2682733, rs1528847, rs716331, rs1948694, rs1997111, rs3884577, rs10732607, rs1426622, rs11064746, rs4129281, rs4128321, rs1520760, rs2239902, rs7953072, rs606443, rs2280168, rs1168067, rs11065286, rs4454799, rs523581, rs1718133, rs1169722, rs2252304, rs11065507, rs1720037, rs7311062, rs11058062, rs7311573, rs11058480, rs11058797, rs11059258, rs2549, rs10847749, rs6488868, rs9739142,

rs3087496, rs11572916, rs1882488, rs11057394, rs11057401, rs1317291, rs11057825, rs11057970, rs12424188, rs10847054, rs7304203, rs2347027, rs4765395, rs2215396, rs2137202, rs1194050, rs2001789, rs1147251, rs1166226, rs1344361, rs1960368, rs906724, rs1910770, rs2248017, rs1879390, rs2171115, rs701069, rs11059784, rs11059814, rs7967621, rs11060224, rs7975245, rs708356, rs7962972, rs1587235, rs975144, rs1881062, rs1195576, rs1236, rs1405525, rs3782288, rs10751695, rs4964941, rs2875200, rs10870520, rs1278607, rs905226, rs905224, rs7298102, rs9317778, rs10507291, rs1947012, rs7996323, rs2209511, rs1459623, rs12870953, rs557381, rs1537922, rs3002104, rs2932165, rs7981959, rs10492508, rs2225275, rs9315569, rs17305480, rs7987204, rs9509275, rs2480432, rs2442449, rs6490605, rs4769128, rs9509372, rs499577, rs17060654, rs9509468, rs1199734, rs7999825, rs9509580, rs261422, rs185482, rs261376, rs17282465, rs1885891, rs10507304, rs17076715, rs292462, rs9317008, rs9506855, rs9317020, rs4340166, rs1572088, rs9580524, rs4536325, rs6490814, rs9318385, rs7327336, rs9512183, rs10507366, rs17539697, rs667208, rs7328925, rs10507367, rs502028, rs567242, rs10507372, rs715958, rs10507373, rs9319327, rs2182929, rs880214, rs10492485, rs2386932, rs9582006, rs7328732, rs17555469, rs17086900, rs1754954, rs731966, rs6490428, rs1747060, rs17631397, rs1073229, rs10488670, rs200505, rs2892545, rs7997142, rs1570613, rs1556428, rs17074898, rs9600625, rs4942614, rs9315107, rs10492599, rs7981822, rs3827693, rs10507401, rs9315120, rs10507402, rs7984972, rs10507403, rs1613660, rs9315132, rs2025908, rs2149079, rs207632, rs1952994, rs7328733, rs718444, rs9591185, rs9315177, rs1924605, rs9315188, rs17078015, rs731088, rs1207573, rs7982726, rs684492, rs9315202, rs536850, rs9315205, rs10492404, rs4943084, rs9597227, rs2147552, rs7981602, rs9315223, rs7319222, rs7333602, rs4350461, rs9542804, rs17051492, rs41341247, rs17775856, rs17051872, rs17197481, rs41339148, rs10507426, rs10507430, rs2225046, rs10507434, rs1171090, rs1170994, rs10514840, rs1927552, rs10507440, rs673064, rs1517885, rs9315443, rs9566247, rs9315508, rs1333363, rs1570607, rs7990029, rs933006, rs10507459, rs4941882, rs10492688, rs1409438, rs1409440, rs1333441, rs9315663, rs10507477, rs7323831, rs7323337, rs2122242, rs9315908, rs10507507, rs727243, rs720824, rs912423, rs10507510, rs9594831, rs2181725, rs9315980, rs1359182, rs9533377, rs9525817, rs9285153, rs1175207, rs2093939, rs1175191, rs7983067, rs1886662, rs963569, rs2760379, rs10492743, rs10492741, rs3783151, rs9316119, rs4942400, rs2405414, rs9316219, rs17068501, rs842365, rs1216987, rs2039095, rs9595589, rs4151423,

rs198618, rs4151509, rs17071716, rs41425345, rs449268, rs753139, rs694322, rs1924372, rs1410113, rs10492411, rs149873, rs1262781, rs1343609, rs7984449, rs7994915, rs2806957, rs10507576, rs1418617, rs964027, rs1550669, rs2408930, rs9316628, rs7319020, rs9316631, rs7338636, rs9316643, rs952811, rs632059, rs7335975, rs2785949, rs1591606, rs796031, rs1010947, rs10444649, rs6561952, rs1417316, rs1340570, rs41526253, rs9527936, rs777776, rs10507651, rs7332781, rs10507652, rs1407575, rs4886250, rs6562127, rs9539011, rs6562153, rs2090139, rs3102213, rs2329302, rs9317195, rs2497629, rs4886367, rs1417460, rs2151037, rs310920, rs10507679, rs1499486, rs1909489, rs9285243, rs10507689, rs1577485, rs17087803, rs1851213, rs269606, rs2136227, rs9317527, rs1343930, rs914840, rs1380888, rs9317546, rs10492541, rs9317555, rs288783, rs7331213, rs7320523, rs1146808, rs2325123, rs727573, rs7334183, rs1009408, rs7328973, rs17084895, rs10507765, rs2039057, rs17087584, rs9529819, rs9317976, rs2202562, rs1041082, rs17620171, rs10162271, rs9542666, rs7326857, rs17089801, rs1029093, rs1333100, rs1410102, rs9565045, rs7321748, rs1983816, rs17065542, rs9573762, rs7320337, rs681020, rs9544627, rs4885491, rs3027096, rs7333867, rs9544636, rs4885499, rs4884077, rs10507878, rs944379, rs2585483, rs9318516, rs2254690, rs980622, rs2265776, rs9318545, rs10507888, rs2001582, rs10507890, rs9318582, rs7327514, rs1417675, rs646679, rs610695, rs4255666, rs1007569, rs1408658, rs9318623, rs314690, rs12858106, rs1023293, rs7985554, rs9318984, rs1334851, rs10492564, rs9319017, rs9319021, rs9319023, rs9531565, rs1928925, rs10507939, rs17078129, rs1888241, rs9319044, rs2149266, rs994126, rs10507954, rs10507955, rs915050, rs10507956, rs10507959, rs2168982, rs9524405, rs9582391, rs9520554, rs4773045, rs7317275, rs7998727, rs9589136, rs17643188, rs7987869, rs1541138, rs828803, rs9589297, rs9523367, rs6492597, rs1180898, rs9523782, rs12431222, rs10492623, rs160149, rs10492622, rs9301850, rs959898, rs701604, rs1328362, rs2057524, rs7981910, rs7992422, rs878765, rs644025, rs1555596, rs9561551, rs9524716, rs3864995, rs9524861, rs1766908, rs4238314, rs962320, rs10161685, rs2173954, rs7319368, rs9556684, rs16954076, rs962586, rs2389910, rs9516953, rs2769285, rs2770222, rs787468, rs9300422, rs4771276, rs7328068, rs10492663, rs9300447, rs536288, rs10508033, rs190788, rs285097, rs7981744, rs7985565, rs10508036, rs9554620, rs9582387, rs1283279, rs1283293, rs1283202, rs2786953, rs16957649, rs1283144, rs10508045, rs915340, rs7336705, rs10508068, rs9557704, rs1898203, rs10508069, rs1436261, rs10508088, rs17690743, rs943669, rs9586171, rs16962475,

rs16963261, rs323480, rs1430957, rs1855661, rs3916951, rs1536360, rs7993755, rs2038899, rs35775092, rs2181302, rs1853518, rs2391465, rs1935132, rs4113422, rs10508187, rs10508191, rs9284241, rs10492420, rs10492419, rs1337930, rs10492412, rs1929293, rs1001843, rs1025410, rs9301375, rs943769, rs1927673, rs1541110, rs831145, rs9324315, rs282606, rs946006, rs10492684, rs1579041, rs561241, rs8001506, rs4907606, rs3168760, rs12584436, rs2259620, rs9590464, rs9562142, rs723395, rs11617448, rs9525207, rs4983173, rs10498263, rs4394996, rs1780870, rs4473104, rs4981655, rs1686549, rs2318502, rs1780909, rs9323233, rs6572904, rs2635568, rs884451, rs10484227, rs2318888, rs17106687, rs2873979, rs1547396, rs8011308, rs10141478, rs17182761, rs3817625, rs7143791, rs12897764, rs2007939, rs17113353, rs3811312, rs1016745, rs4517706, rs11625840, rs5742847, rs7152605, rs17110034, rs10498283, rs10498285, rs1959792, rs2614517, rs2332634, rs910333, rs10483310, rs4981791, rs12432689, rs8014942, rs7155894, rs442149, rs12435286, rs4261436, rs2748829, rs9322914, rs7151730, rs1279323, rs4982057, rs10483431, rs7141967, rs2274511, rs1315146, rs10483440, rs8019556, rs7149200, rs2383678, rs8009854, rs10483452, rs10140985, rs10138222, rs1958075, rs2415317, rs12433852, rs1766120, rs7140243, rs11624944, rs17176845, rs995943, rs7148646, rs17106785, rs11156961, rs7147379, rs177852, rs12882123, rs1885140, rs34664345, rs2749483, rs10483504, rs9323017, rs8007192, rs10483503, rs10483500, rs10483499, rs17110823, rs10483498, rs1958882, rs1185821, rs11629375, rs6572042, rs41502150, rs766582, rs2415722, rs725996, rs2256697, rs1483912, rs2062472, rs1353844, rs8018324, rs12891750, rs8015068, rs8018748, rs1698507, rs2022784, rs921315, rs2044747, rs1449834, rs2246576, rs17113932, rs10498379, rs2415799, rs12879964, rs17114076, rs1021485, rs8020694, rs17114666, rs17212883, rs4906516, rs11624198, rs17309337, rs17648719, rs10149060, rs229734, rs1424886, rs10483549, rs2033385, rs1957396, rs17116036, rs10133001, rs17116137, rs7155417, rs2415899, rs1906809, rs1266217, rs10483584, rs8005375, rs2415975, rs2415990, rs17117516, rs10140329, rs10483573, rs4638482, rs8019096, rs10483569, rs10483567, rs7157951, rs2022694, rs7146384, rs8016865, rs17119697, rs1959541, rs2790587, rs2354445, rs10146912, rs8011961, rs4284545, rs4363775, rs3100919, rs7145997, rs11157746, rs10483610, rs1014990, rs764964, rs7145411, rs17122988, rs17123103, rs8006455, rs10483609, rs9323202, rs10483608, rs1956575, rs9671722, rs11157868, rs2357307, rs11623414, rs10483613, rs10144318, rs722290, rs11624787, rs2884345, rs1952089, rs1112777, rs8009114, rs210368, rs2183511, rs4027004, rs2067562, rs2071047, rs9671848, rs8015211,

rs17128455, rs946065, rs4143891, rs10483644, rs10498477, rs10498478, rs7146449, rs1033732, rs1262174, rs8008796, rs4901985, rs1950312, rs1955694, rs7144582, rs17097755, rs17098514, rs10483743, rs17098848, rs10483747, rs2274070, rs1660647, rs217692, rs8005321, rs7160998, rs10498492, rs17735411, rs17099628, rs4899071, rs8007070, rs10483752, rs2220530, rs2101552, rs10483755, rs10483756, rs9323422, rs8013931, rs1271565, rs7146821, rs1255986, rs8012652, rs1256542, rs7147624, rs10483776, rs10483778, rs10483779, rs10483780, rs1113962, rs10483781, rs7142317, rs13353130, rs8021730, rs2478037, rs7160601, rs6573776, rs12879200, rs17835428, rs8015876, rs2001355, rs1275408, rs11622889, rs7157772, rs2096023, rs4902702, rs11620883, rs12433032, rs1954119, rs2184599, rs11626232, rs41420146, rs12436698, rs149667, rs17117326, rs2333021, rs177369, rs1014087, rs4899530, rs1569328, rs1110985, rs12433257, rs951304, rs4903393, rs12590670, rs1676235, rs7160845, rs1642873, rs4903435, rs11159220, rs850746, rs17783450, rs17105180, rs2655995, rs158120, rs2017792, rs17751406, rs17105954, rs10483892, rs4899701, rs10483896, rs2063985, rs10483897, rs4903741, rs10483899, rs10483901, rs10483905, rs7144011, rs221486, rs11845389, rs221440, rs10141508, rs12895242, rs8011971, rs8020755, rs2372469, rs10146565, rs17119298, rs7157884, rs10138991, rs856692, rs709857, rs10484113, rs10498577, rs10498578, rs10498580, rs1767410, rs1767418, rs10498581, rs2069144, rs2057115, rs4904262, rs10483981, rs10483982, rs9323778, rs10498594, rs10498597, rs7492316, rs17258847, rs2185461, rs1954096, rs10484095, rs10484099, rs10484100, rs2022643, rs10484102, rs2022773, rs1769455, rs10498610, rs917608, rs1756650, rs437381, rs1430561, rs10483994, rs3850388, rs2295135, rs2297124, rs1152383, rs1956410, rs10484010, rs9323834, rs10484008, rs41463644, rs762017, rs8006542, rs10147606, rs11627126, rs2001834, rs10498620, rs10484025, rs2018796, rs10498621, rs384740, rs10484012, rs10484014, rs2181663, rs10484016, rs1952774, rs8015271, rs2300502, rs7146008, rs2401980, rs11159995, rs2540860, rs4900075, rs3814837, rs10498630, rs10498631, rs10498632, rs4904828, rs2749509, rs2402277, rs7151015, rs10146795, rs11626422, rs12437224, rs17825343, rs17826032, rs997280, rs1955649, rs9323914, rs1243516, rs2983478, rs10498640, rs7147709, rs2282265, rs10498642, rs7149029, rs748839, rs8010752, rs1209080, rs17828361, rs17092581, rs7147447, rs17093106, rs2145632, rs941774, rs1998245, rs2093274, rs1951801, rs2369540, rs10498648, rs965950, rs1570558, rs234565, rs9323947, rs2025357, rs912346, rs11625059, rs2224442, rs9285600, rs17094510, rs4905564, rs10484164, rs10484166, rs1569802, rs1683147, rs10484167, rs10484169, rs2129022, rs922966,

rs8011773, rs3850417, rs41507344, rs234443, rs1552126, rs17095552, rs17095553, rs17095591, rs17095597, rs17095742, rs8017411, rs8021134, rs1350275, rs897713, rs10484131, rs1461575, rs4900386, rs1381281, rs17096574, rs10484128, rs17775184, rs17775588, rs17096700, rs1257939, rs11850908, rs17595072, rs1956837, rs4905752, rs8014257, rs10484060, rs10484061, rs2400464, rs1957509, rs10144242, rs7149242, rs10142873, rs7150269, rs7154697, rs7148324, rs2274045, rs2277471, rs7154538, rs941725, rs2144826, rs10484072, rs10484071, rs962230, rs1951389, rs7155822, rs941475, rs722637, rs1040812, rs4906451, rs11160805, rs7146045, rs10146433, rs4465541, rs7146030, rs6644, rs4983387, rs2841245, rs1048257, rs2338192, rs10484074, rs2027912, rs7150731, rs17113284, rs2097579, rs7146073, rs9324094, rs10129255, rs4773949, rs4774028, rs41504149, rs12594669, rs17134298, rs4247069, rs6600090, rs2343648, rs4984083, rs2626269, rs7166137, rs1346662, rs2077885, rs1303908, rs10519379, rs711864, rs2289818, rs7174982, rs4410051, rs1405186, rs10519440, rs850814, rs10519450, rs3858933, rs1846338, rs1119458, rs11161080, rs7495302, rs7496441, rs9920573, rs11854962, rs12908526, rs11636117, rs17114602, rs11161135, rs11161154, rs220027, rs1991274, rs2732036, rs17115060, rs4274409, rs8030752, rs12592517, rs17115725, rs2175462, rs10519542, rs10519533, rs7167382, rs920114, rs10519545, rs1346263, rs17116950, rs4906676, rs7164232, rs8027455, rs4906680, rs10519563, rs17646555, rs2873027, rs6606854, rs17561681, rs4887532, rs10519582, rs1382061, rs1947744, rs10519611, rs768547, rs4778140, rs10438451, rs12324794, rs4603522, rs4779952, rs12101510, rs8027951, rs8028519, rs11852466, rs798087, rs7171208, rs7174166, rs7174211, rs11852488, rs4354896, rs11071016, rs6493668, rs2338684, rs7178180, rs16956838, rs908001, rs6494216, rs11852956, rs35057608, rs8041763, rs286095, rs921511, rs16959625, rs10519760, rs544432, rs3829481, rs11855526, rs2928021, rs343916, rs237746, rs10519771, rs10519780, rs10519789, rs3850097, rs11853646, rs655501, rs636842, rs10519916, rs16959391, rs1521849, rs1402861, rs1901417, rs3858931, rs10519967, rs41473046, rs318360, rs877163, rs10519999, rs1822533, rs2256109, rs10520033, rs10520038, rs6495808, rs7169565, rs1517867, rs4924055, rs10518873, rs768952, rs10518883, rs2034705, rs2890806, rs723831, rs10518905, rs1901127, rs10518924, rs10518928, rs8039802, rs10518931, rs603575, rs1840904, rs8037685, rs1379351, rs4128139, rs10520089, rs1498418, rs7167587, rs11073342, rs2929639, rs2929660, rs4924304, rs7497788, rs1368801, rs967498, rs2082584, rs1470148, rs724098, rs1382445, rs753599, rs7168755, rs10520153, rs275754, rs1836847, rs275737, rs3959527, rs4924437,

rs1075505, rs10518693, rs896797, rs11852419, rs8039934, rs8034073, rs6493050, rs16957168, rs4924705, rs8040769, rs502157, rs17779494, rs514438, rs13380265, rs533143, rs16953895, rs12594110, rs8023453, rs2123148, rs4774542, rs2433625, rs2467861, rs1442797, rs2218309, rs16946803, rs651990, rs11070471, rs932080, rs1918505, rs4363807, rs11070502, rs10519050, rs10519055, rs1385080, rs10519057, rs10519059, rs551562, rs652281, rs16960413, rs10519171, rs10519174, rs10519184, rs668842, rs10519193, rs2009404, rs11638981, rs10519206, rs685172, rs11858114, rs2086255, rs2059935, rs8024102, rs10519234, rs10519238, rs1484555, rs8034382, rs6493399, rs10744956, rs6493470, rs1124769, rs7170736, rs1111266, rs2554355, rs1811326, rs940973, rs2165991, rs17545090, rs513117, rs560728, rs17198145, rs2711584, rs1159883, rs9302181, rs1818704, rs2078426, rs6493709, rs10518778, rs2681992, rs7163282, rs10518808, rs8041885, rs2447713, rs1075938, rs4774777, rs10518817, rs2414428, rs2303580, rs7174459, rs2962994, rs10518898, rs935329, rs978274, rs10518904, rs17820119, rs8034843, rs10518909, rs2431016, rs7177670, rs4774941, rs10518922, rs7181170, rs937250, rs527693, rs2249783, rs2017566, rs10518968, rs261264, rs402345, rs10518976, rs10518982, rs16940810, rs7162584, rs7496680, rs2414613, rs6494052, rs10518995, rs10519000, rs2306786, rs725463, rs173036, rs8026117, rs338415, rs10519017, rs10519012, rs7172438, rs11854222, rs8037796, rs17271535, rs8032921, rs1836541, rs16945335, rs10519173, rs486073, rs16946127, rs6494466, rs11855072, rs8031061, rs10444844, rs16949590, rs12438505, rs266370, rs7170443, rs371302, rs33983186, rs12907457, rs10518705, rs11634686, rs10851772, rs731874, rs12595334, rs10518716, rs12593640, rs2448137, rs1489595, rs10518758, rs7172828, rs3784334, rs964691, rs3816612, rs2018282, rs736172, rs615188, rs1565563, rs897001, rs2958394, rs905614, rs10518889, rs9744287, rs907555, rs11632910, rs1983033, rs954458, rs7169459, rs8033100, rs8027192, rs17737742, rs10518970, rs9302260, rs7176701, rs10519014, rs1349642, rs1440101, rs11072468, rs893814, rs10519048, rs2198843, rs7342601, rs11072528, rs10851883, rs10519109, rs2648435, rs1503954, rs2046416, rs12914345, rs12916973, rs9920633, rs8040813, rs10519182, rs11072726, rs11630776, rs10519268, rs282802, rs10519247, rs10519277, rs10519281, rs2866592, rs10519286, rs10519291, rs4778908, rs7176423, rs949898, rs8024021, rs1045508, rs1846911, rs12443224, rs11073036, rs3973890, rs17158372, rs10520577, rs10520581, rs2562772, rs2895931, rs17158772, rs2244838, rs1117097, rs2554382, rs10520575, rs10520571, rs2010790, rs1849287, rs17532346, rs2879828, rs1429444, rs289386, rs2174218, rs49363, rs10520601, rs10520606,

rs7167642, rs4506862, rs10520610, rs9302343, rs1433453, rs10520647, rs11632912, rs953065, rs10520679, rs2351254, rs10520681, rs293385, rs875390, rs718457, rs2882557, rs2351002, rs11633274, rs10584, rs1269077, rs2970359, rs1877782, rs1125314, rs4509991, rs7182301, rs4932597, rs11638063, rs2215084, rs10520704, rs10520709, rs10520710, rs1455780, rs1826853, rs426191, rs285723, rs881268, rs2387916, rs4381546, rs10520718, rs3887013, rs10520720, rs4396488, rs733036, rs723033, rs4777858, rs8034122, rs10520729, rs10520730, rs2388299, rs7182433, rs10520737, rs10520738, rs10520739, rs1573086, rs1351306, rs10520742, rs724408, rs10520769, rs1448646, rs2125310, rs290674, rs16949858, rs725250, rs10520775, rs10520777, rs8039182, rs10520780, rs1834213, rs9302333, rs2639187, rs725213, rs10520802, rs9302334, rs4984419, rs10520809, rs2049167, rs1503353, rs992171, rs234513, rs1398961, rs1043374, rs1491187, rs7172170, rs9920491, rs1442799, rs1837993, rs1372847, rs1867156, rs1543106, rs1966764, rs2411838, rs894316, rs1551466, rs936111, rs2012387, rs1947942, rs963172, rs1994967, rs714647, rs8038697, rs1984528, rs12900200, rs516667, rs7172905, rs1052887, rs2456491, rs352735, rs352716, rs41340949, rs1203957, rs13339109, rs1203981, rs11248914, rs2885415, rs2301487, rs1045274, rs1544799, rs591332, rs2281236, rs10500322, rs758335, rs8051877, rs3211995, rs10500324, rs2107321, rs4785913, rs2285826, rs757166, rs4149782, rs2526270, rs2526275, rs7199221, rs224199, rs7187479, rs11077325, rs1231089, rs3848356, rs4786421, rs2074523, rs13332500, rs1859379, rs740862, rs11541712, rs231619, rs17256406, rs514346, rs4786684, rs12930683, rs12149334, rs4420530, rs9646295, rs2795546, rs41530250, rs9302828, rs6500906, rs1478715, rs11077135, rs10500348, rs9936520, rs8051751, rs2346606, rs7196063, rs28405182, rs726475, rs9940403, rs4787048, rs7205010, rs10521084, rs8055847, rs1074042, rs8052454, rs8062216, rs1833167, rs1833161, rs10500369, rs10500371, rs2352740, rs4780892, rs12924729, rs9746695, rs6498169, rs166054, rs168716, rs181578, rs830723, rs13335852, rs1641882, rs2115105, rs16960309, rs2865630, rs1846900, rs2134036, rs1501315, rs276603, rs1230896, rs1898680, rs10521099, rs10521098, rs2078954, rs916069, rs179620, rs1424278, rs231128, rs2903407, rs3136094, rs7192563, rs2071332, rs924136, rs4148343, rs4148353, rs7202970, rs1909090, rs1008955, rs2311139, rs722074, rs2059283, rs9936172, rs2361778, rs11865355, rs10492785, rs7190644, rs1548447, rs2074037, rs8055485, rs1292641, rs1925485, rs727590, rs10521114, rs2221448, rs163235, rs163260, rs163250, rs764138, rs1027457, rs2245256, rs16970847, rs11649675, rs7191119, rs11862108, rs2283526,

rs10492789, rs2369690, rs8047644, rs756813, rs250584, rs30012, rs4968005, rs16940361, rs35635, rs152041, rs196008, rs886116, rs8059655, rs10492798, rs10521128, rs16974119, rs8051759, rs13338696, rs17624477, rs7205696, rs17702912, rs6497852, rs9302435, rs182678, rs4787386, rs474503, rs16976493, rs7184516, rs7201146, rs12443684, rs17706614, rs245744, rs10521144, rs715337, rs3922800, rs16939923, rs8054903, rs10521145, rs1627843, rs166152, rs1364182, rs6565189, rs3751853, rs8050193, rs8057877, rs10492807, rs12444740, rs4990678, rs4106863, rs1911064, rs4090952, rs7500098, rs7500645, rs9939624, rs11149544, rs2404337, rs4581708, rs7197337, rs16945380, rs1436435, rs4967156, rs4966571, rs7186662, rs794558, rs370159, rs36469, rs10492855, rs734309, rs1362406, rs9328700, rs10518838, rs10518841, rs9328592, rs10521162, rs1011532, rs10521163, rs9328600, rs876258, rs16945553, rs16945613, rs16945662, rs10492847, rs9926879, rs1004704, rs1968903, rs1420718, rs2058816, rs1420595, rs1362587, rs3944008, rs7191243, rs12598711, rs2216263, rs152650, rs747762, rs9924026, rs9926131, rs16948672, rs4785450, rs7205760, rs12927486, rs16949757, rs2379053, rs1477012, rs16951021, rs4784221, rs7206384, rs10521275, rs9937509, rs1549041, rs1894904, rs1833202, rs8045574, rs2110844, rs16952242, rs10521289, rs10521293, rs12597471, rs12444305, rs7202836, rs1108102, rs16953604, rs10521316, rs12051467, rs4293375, rs11647177, rs11639960, rs12708952, rs8182127, rs4479219, rs258094, rs10521334, rs2175244, rs1548918, rs8056599, rs963300, rs4784708, rs2118017, rs891139, rs2303790, rs27193, rs9922349, rs11076193, rs8055133, rs4783997, rs17241313, rs11862843, rs7187710, rs11076300, rs8047476, rs8047336, rs11076347, rs1550498, rs9889057, rs1155406, rs2407318, rs1510213, rs765883, rs4329932, rs2098721, rs9302558, rs6498937, rs520153, rs10500496, rs1074651, rs716079, rs10492856, rs9302565, rs4578668, rs8056507, rs1879261, rs7204297, rs2061787, rs16956948, rs10500541, rs16957524, rs10500542, rs12927428, rs4783633, rs4783665, rs4783573, rs10500544, rs10500546, rs10500549, rs728546, rs8045482, rs9921696, rs1551528, rs236000, rs12447045, rs7205297, rs2287998, rs16973636, rs8059437, rs150617, rs3812985, rs11648624, rs7184508, rs1001722, rs2127740, rs7191369, rs12445942, rs4329938, rs8058922, rs889694, rs3743921, rs13337868, rs10514390, rs1559361, rs10514393, rs9319484, rs11149841, rs6564297, rs13337655, rs9922157, rs4888050, rs7191101, rs6564763, rs2316157, rs17823453, rs4889213, rs3751858, rs11866488, rs8047817, rs6564958, rs10514554, rs1462035, rs7185386, rs10492858, rs4783294, rs10492864, rs10492865, rs10492869, rs3935907, rs4075464, rs10514587, rs10514585, rs1424185, rs1125292,

rs6563911, rs10514596, rs433325, rs10514600, rs395111, rs8053461, rs2136665, rs1364256, rs10514603, rs8063197, rs4782607, rs962877, rs2966312, rs1429264, rs774310, rs2646128, rs721004, rs16975059, rs9319454, rs4072154, rs8587, rs2599084, rs9308363, rs10514611, rs908979, rs7184268, rs10514613, rs276992, rs717482, rs10514616, rs13334640, rs1918829, rs889594, rs2306967, rs3866634, rs10514617, rs387953, rs11863161, rs8062287, rs3887300, rs8059887, rs3849247, rs16942711, rs10514620, rs1862788, rs10514621, rs1366521, rs9922572, rs8047318, rs2879906, rs8062916, rs2019604, rs659974, rs2238527, rs7184960, rs9302773, rs2302513, rs6565733, rs9896436, rs4617924, rs4556857, rs11868422, rs2360735, rs10521109, rs561261, rs2586274, rs2259992, rs2258130, rs4318271, rs9303097, rs10521113, rs7216863, rs12952857, rs744400, rs4525525, rs4061659, rs231678, rs1601909, rs151130, rs661835, rs224551, rs16953498, rs1558294, rs2325788, rs1062683, rs9890496, rs7211542, rs11078512, rs1038121, rs7221907, rs733099, rs2243100, rs4790719, rs1056626, rs6502832, rs3026105, rs1806261, rs11652873, rs4790796, rs10852880, rs952849, rs930526, rs10491082, rs10491084, rs8076947, rs10521149, rs374177, rs1443419, rs10521152, rs8067500, rs2078486, rs3736306, rs9895704, rs7218733, rs3027209, rs9899533, rs1024067, rs9303230, rs10491087, rs10521155, rs2315141, rs10521157, rs2125348, rs6503235, rs10521159, rs4791858, rs531437, rs16959287, rs2240577, rs11869220, rs6503352, rs11867580, rs7225328, rs9913094, rs237259, rs10491191, rs237302, rs1401539, rs4791505, rs10491101, rs10521199, rs2215053, rs10521204, rs10521207, rs2159040, rs764191, rs2521892, rs10521211, rs1541350, rs10521215, rs10521217, rs4792359, rs3859253, rs2996026, rs10521223, rs7210104, rs726799, rs9915220, rs1860124, rs8068052, rs7222384, rs10521248, rs10852820, rs9901800, rs9891988, rs3785658, rs10521268, rs10521269, rs10521272, rs2080115, rs471792, rs7219146, rs12450400, rs11868091, rs11657710, rs9303127, rs231008, rs230947, rs55568, rs973761, rs433068, rs2323659, rs3803842, rs716389, rs163372, rs859232, rs859245, rs859264, rs17715109, rs758853, rs8076864, rs4791662, rs764984, rs941411, rs10491105, rs10491106, rs1005369, rs4985741, rs12449964, rs11653424, rs4584886, rs8080951, rs4924758, rs2649485, rs2530005, rs4924941, rs7211239, rs4924785, rs2240096, rs7211758, rs8080953, rs205111, rs17686622, rs2703813, rs2703815, rs2158473, rs12603372, rs10512426, rs10512425, rs1856276, rs899342, rs3744227, rs9889237, rs9906072, rs1975974, rs6565381, rs8073228, rs4889736, rs4889705, rs33962847, rs11150730, rs2008032, rs2948532, rs747959, rs6505524, rs10512428, rs8069132, rs11871640, rs12051648, rs8068628, rs10512430,

rs1023682, rs9303621, rs9895443, rs7221773, rs6505097, rs1319486, rs7208383, rs6505114, rs3785961, rs10491212, rs16964983, rs1061342, rs7215506, rs7502260, rs7503395, rs12603885, rs1124918, rs2952989, rs10512433, rs10512435, rs4795616, rs8072678, rs223128, rs17181735, rs223154, rs11080162, rs16972368, rs9893975, rs16966835, rs10512436, rs15654, rs2078406, rs1034593, rs2032753, rs10512439, rs10512440, rs2466830, rs2470209, rs4795746, rs319771, rs423022, rs16968180, rs11651326, rs17836785, rs2347154, rs6505339, rs12602581, rs3892103, rs17191701, rs3115684, rs17836917, rs7215199, rs7214667, rs317370, rs4795858, rs10491110, rs1080327, rs1860182, rs442319, rs9889895, rs11652590, rs10512466, rs16970611, rs8071313, rs7225958, rs1994089, rs10512467, rs16970764, rs1480945, rs12601614, rs10512468, rs772104, rs10512469, rs1531057, rs9303689, rs226088, rs226437, rs7209512, rs4239252, rs2306630, rs2526333, rs854633, rs1015673, rs8072238, rs17560870, rs17138364, rs10512480, rs9286331, rs9330249, rs2017571, rs2305098, rs9330250, rs763512, rs6607284, rs34557151, rs1985643, rs17705177, rs1989668, rs10512474, rs2677185, rs1733805, rs3785744, rs4511574, rs7226222, rs4239222, rs2941504, rs2517956, rs4252612, rs907092, rs9941360, rs9303277, rs8077456, rs2302775, rs8078399, rs10512481, rs17678694, rs16965666, rs803125, rs1048572, rs10512483, rs4132126, rs2469828, rs16966398, rs2023873, rs10491139, rs10491134, rs9303301, rs8072687, rs401645, rs2191377, rs10512484, rs10512485, rs10491132, rs2106852, rs11870552, rs7213435, rs7406717, rs9903086, rs1529933, rs9912300, rs6503675, rs7218653, rs8067443, rs12601982, rs7214981, rs2269906, rs5027, rs12603993, rs7502443, rs11867692, rs4793124, rs12450654, rs9902879, rs16970963, rs739454, rs4792855, rs2693371, rs17760577, rs17649162, rs17334894, rs12944712, rs10491140, rs17770337, rs17564223, rs17651213, rs1981998, rs17574228, rs17575556, rs17659881, rs3912061, rs10514901, rs2077551, rs1528072, rs2696440, rs2532418, rs2732706, rs2732613, rs199449, rs197912, rs9303532, rs2317996, rs3883305, rs2873131, rs1634271, rs11570508, rs221599, rs11570441, rs9895150, rs1912481, rs10514925, rs12452315, rs10514928, rs11869926, rs7214799, rs4239162, rs8068453, rs727972, rs17774144, rs4793688, rs7207225, rs9895863, rs16949784, rs2525088, rs2525100, rs41429650, rs10491182, rs1316657, rs11868509, rs7218848, rs12452773, rs6504404, rs1320283, rs8073244, rs1523135, rs11653468, rs2091040, rs6504600, rs4438351, rs2411899, rs8077603, rs11868965, rs1319888, rs16948381, rs8079058, rs7221526, rs3098956, rs17714590, rs10491150, rs3815377, rs11650549, rs2318782, rs9910086, rs4794220, rs2073866, rs1263951, rs1263962, rs203042,

rs8065627, rs1393735, rs2970052, rs2931364, rs4605214, rs10514998, rs10515001, rs1034038, rs1352192, rs1486747, rs7226036, rs10515009, rs10515012, rs16951593, rs1492219, rs8073239, rs7221303, rs1858465, rs1398514, rs807140, rs1074075, rs9303613, rs806920, rs7207189, rs7224597, rs11079107, rs7220060, rs17672190, rs9904757, rs1366901, rs1835221, rs8075693, rs8068574, rs12936957, rs958556, rs244308, rs244293, rs7219986, rs10515098, rs10515101, rs986959, rs10515104, rs16956222, rs9904246, rs7225836, rs16957057, rs9303385, rs929585, rs10515125, rs10515131, rs10515133, rs10491159, rs227698, rs227683, rs963292, rs10515134, rs6503766, rs7209070, rs7216334, rs3853825, rs2586063, rs16942693, rs4372750, rs7212825, rs1292042, rs41363245, rs180511, rs41458547, rs237969, rs8064423, rs9897885, rs1197065, rs10491184, rs8075512, rs930528, rs10506521, rs10491167, rs9906747, rs17631783, rs8081612, rs11658329, rs721575, rs6504177, rs196922, rs10512499, rs10512502, rs9303474, rs9906016, rs16960282, rs1036893, rs10514869, rs2292593, rs4791131, rs9894598, rs7206972, rs7222710, rs16959238, rs7221805, rs3848418, rs4622543, rs7219499, rs17686174, rs9303511, rs4644888, rs3848417, rs973075, rs10491170, rs10512516, rs2706682, rs3935969, rs6504564, rs6504573, rs7213585, rs1860040, rs7215687, rs7222649, rs2952280, rs4254382, rs8078836, rs11077860, rs17684521, rs11650025, rs2302133, rs333916, rs707246, rs9302900, rs8078890, rs763698, rs2157988, rs6501346, rs1858964, rs10512533, rs4328485, rs1514238, rs10512538, rs723498, rs312732, rs312691, rs12603464, rs2366790, rs10491172, rs16976050, rs437518, rs7208743, rs17763885, rs41473444, rs8065724, rs1114982, rs10512544, rs917345, rs9302935, rs9893719, rs17766990, rs8081586, rs10512577, rs2253624, rs10512578, rs10512579, rs34001630, rs11652803, rs759492, rs918080, rs11650866, rs7220150, rs12939271, rs1029648, rs10512584, rs7224570, rs10512588, rs2713960, rs10512589, rs10512590, rs10512591, rs10512594, rs17781867, rs9302960, rs4969097, rs12601153, rs1872083, rs7207590, rs2586835, rs12938663, rs508255, rs4789114, rs10852758, rs12952277, rs16967770, rs1671035, rs820211, rs10512605, rs7221225, rs11077829, rs9898576, rs12450896, rs7220258, rs8069820, rs8079872, rs869693, rs11658050, rs10512614, rs8080475, rs16970482, rs1965780, rs10512615, rs16970689, rs17639052, rs16970803, rs9302881, rs11654527, rs1384367, rs6501252, rs9302889, rs2045660, rs4789960, rs2377402, rs872276, rs8070170, rs7216806, rs4074469, rs4313838, rs8076446, rs9897213, rs745570, rs1115834, rs2361701, rs6565651, rs12942637, rs1126064, rs7208502, rs3898096, rs2333990, rs8072124, rs4129124, rs2271090, rs1017800, rs4077056, rs12449687,

rs9916764, rs7226049, rs3935402, rs9271, rs2306755, rs9898649, rs7221423, rs7406561, rs7235612, rs2847035, rs7234528, rs655781, rs600220, rs644438, rs1006487, rs722725, rs2341746, rs615572, rs508969, rs485373, rs2244500, rs1051527, rs572600, rs2846599, rs2846581, rs4798777, rs1085998, rs715647, rs1821619, rs16977062, rs1995715, rs1146069, rs1018197, rs10513945, rs10513938, rs10513935, rs10513934, rs11877976, rs1365237, rs7235479, rs17552342, rs568289, rs1791118, rs7228082, rs10513868, rs10513866, rs4798124, rs10502314, rs3915772, rs10502319, rs8084562, rs10502320, rs6506242, rs1501044, rs2202067, rs1501040, rs291641, rs1395064, rs454592, rs727616, rs10502330, rs1719976, rs1785394, rs1719939, rs9960907, rs11081211, rs10502334, rs1940622, rs601748, rs4798427, rs541088, rs10502340, rs10502344, rs10502341, rs528801, rs7232015, rs10493576, rs341184, rs7504263, rs1941491, rs1941507, rs8091694, rs10502351, rs3865406, rs508366, rs1831779, rs10502348, rs484528, rs450015, rs10502354, rs333106, rs2007808, rs1018250, rs918213, rs7237402, rs477445, rs16952004, rs10502357, rs640128, rs10502359, rs8091461, rs331415, rs2099790, rs10502364, rs10502365, rs9949799, rs8089170, rs674823, rs619957, rs7240104, rs10513899, rs10502368, rs10502369, rs2242148, rs10502370, rs727368, rs1372778, rs690336, rs1481042, rs595107, rs2377959, rs2377961, rs4148967, rs1443597, rs3898762, rs1787166, rs2124297, rs8099036, rs2267568, rs688248, rs9304048, rs29064, rs29027, rs541164, rs1861156, rs1893211, rs10513906, rs10502395, rs3865365, rs16974765, rs10502394, rs553331, rs539632, rs674698, rs1189850, rs3898148, rs10502402, rs1385740, rs7244525, rs754969, rs3975417, rs9303722, rs1119362, rs10502411, rs10502409, rs1477940, rs1551898, rs12967203, rs2161961, rs9303749, rs10083973, rs1787988, rs649039, rs4797619, rs7243316, rs533683, rs10502414, rs16940004, rs562151, rs550315, rs1540079, rs7241109, rs10502420, rs4797775, rs1559865, rs4796997, rs8091911, rs1940906, rs7233911, rs10502425, rs9303798, rs4797859, rs8088014, rs507579, rs576952, rs6505882, rs3905904, rs10502427, rs1846090, rs4086824, rs4584916, rs786064, rs786038, rs2945660, rs10502428, rs4085410, rs12605904, rs7237967, rs4096978, rs7227666, rs7235880, rs4800741, rs11083186, rs10502435, rs2276157, rs1871510, rs1871508, rs10502434, rs8099549, rs10502432, rs4072873, rs10502431, rs494470, rs12958098, rs4264496, rs7236387, rs3844227, rs16973631, rs965578, rs4474794, rs7226453, rs4800467, rs12607475, rs12454564, rs1945154, rs9951762, rs16940996, rs7227028, rs1668834, rs8093520, rs1971613, rs1786725, rs2851752, rs12954176, rs9956258, rs8085190, rs7232841, rs1504107, rs1618992, rs1692491,

rs10502513, rs7229680, rs4505413, rs2418844, rs10502540, rs8087497, rs10502544, rs1372943, rs10502568, rs3859362, rs7240789, rs10502571, rs34530749, rs9963036, rs12608432, rs4799325, rs7232848, rs10502600, rs12454779, rs10502612, rs9956150, rs462998, rs271452, rs4799697, rs6507033, rs6507051, rs10502625, rs1389535, rs16964887, rs9304128, rs17753785, rs10502621, rs8098255, rs10502619, rs10502615, rs4413039, rs2177073, rs6507093, rs10502629, rs1439128, rs10502635, rs4799780, rs949216, rs10502641, rs10502655, rs878971, rs7227862, rs10502652, rs10502651, rs3826600, rs10502657, rs1893271, rs1398952, rs10502662, rs1076993, rs7238909, rs10502691, rs10502698, rs1893661, rs10502703, rs1943413, rs10502708, rs9304196, rs10502709, rs7243290, rs10502717, rs9961264, rs954106, rs1943152, rs2163544, rs12963887, rs2043186, rs2589035, rs478003, rs2670569, rs1513679, rs1437010, rs2469872, rs10502746, rs10502747, rs10502748, rs591011, rs4506998, rs8087566, rs2848768, rs10502766, rs2612333, rs10502770, rs2587613, rs10502774, rs970238, rs10502775, rs9304254, rs2334943, rs52911, rs11874830, rs1941538, rs10502779, rs10502781, rs8095186, rs9304270, rs421138, rs1594436, rs8091090, rs538445, rs10502799, rs10502802, rs17635858, rs473329, rs9958995, rs10502807, rs4132437, rs4890428, rs10502824, rs2359882, rs978490, rs10502827, rs9304310, rs10502831, rs10502849, rs10502851, rs10502853, rs1450805, rs10502858, rs10502860, rs16978318, rs2885618, rs2612545, rs2612581, rs1362832, rs12455090, rs1075906, rs1800639, rs7235500, rs8086956, rs11082521, rs1470324, rs16952734, rs7506314, rs8094592, rs1011420, rs357897, rs7238988, rs8085780, rs7236575, rs1943000, rs12606493, rs2044012, rs1822460, rs9958074, rs1261085, rs2276195, rs2924329, rs2958188, rs17597288, rs7236100, rs9955956, rs784237, rs1978503, rs4940770, rs10503013, rs576678, rs624961, rs11659760, rs317809, rs17064158, rs4941229, rs520210, rs6567020, rs2564486, rs2851843, rs1864309, rs7229174, rs9950483, rs12458380, rs17700028, rs10515983, rs7243575, rs10503046, rs1497965, rs720261, rs7239405, rs10503083, rs1395266, rs1522722, rs1506430, rs9320032, rs12971105, rs41324847, rs1907415, rs8091655, rs11151296, rs17076659, rs10516001, rs9945435, rs2045262, rs8099629, rs9319742, rs1551739, rs6566339, rs10503129, rs10503139, rs951666, rs1573400, rs11877565, rs11660282, rs7243624, rs11663149, rs12607448, rs2034022, rs1017512, rs7230674, rs10513969, rs7506960, rs10514077, rs4892123, rs4132122, rs7227420, rs10514094, rs10514113, rs1943933, rs1113144, rs10514110, rs8095376, rs17088860, rs10514116, rs4891538, rs1861923, rs9959340, rs9319907, rs3794941, rs494721, rs8087967, rs17055816, rs8099215, rs7226800, rs7238886,

rs2452654, rs925144, rs6566067, rs10514165, rs10514166, rs7407139, rs9319680, rs10514172, rs10514176, rs2584505, rs4522494, rs1943212, rs1943196, rs2612362, rs9319636, rs10514190, rs10514194, rs10514196, rs1702498, rs7242772, rs8096972, rs11150978, rs17060158, rs470144, rs3794832, rs7242877, rs1944550, rs2027742, rs948720, rs1506260, rs1587893, rs1944014, rs11081609, rs626549, rs646700, rs3859327, rs668335, rs1942310, rs589394, rs70198, rs673590, rs632281, rs2126083, rs612913, rs2176729, rs4799135, rs1064059, rs1879105, rs2139393, rs8100066, rs11883060, rs3915789, rs7408247, rs6510799, rs8107361, rs758207, rs17684904, rs10500203, rs2385821, rs10518240, rs12610522, rs759071, rs6510699, rs9304898, rs6510704, rs1860192, rs10518241, rs8109485, rs11668329, rs8110283, rs2060247, rs350825, rs3760905, rs243359, rs10518242, rs10518243, rs10518244, rs1384936, rs809374, rs10518245, rs952435, rs3763046, rs3760776, rs11881470, rs639251, rs1110624, rs9304930, rs348384, rs339408, rs460698, rs6510942, rs966591, rs16994131, rs2860173, rs4804596, rs6603060, rs12979990, rs1549257, rs2161568, rs501580, rs10518270, rs568356, rs11260036, rs552797, rs14394, rs10416634, rs17261689, rs1582532, rs1895364, rs17000819, rs11666596, rs9305056, rs10500207, rs1583295, rs1820114, rs7255032, rs10407514, rs6511677, rs7254567, rs17000211, rs2569702, rs3745264, rs3176768, rs12720305, rs11670504, rs10409101, rs10439163, rs10405617, rs10419865, rs2738042, rs892086, rs399878, rs317915, rs431144, rs311784, rs2302972, rs8105597, rs6511739, rs2161250, rs7249531, rs10411270, rs895819, rs3803894, rs12979318, rs11669213, rs10426847, rs6511939, rs2396225, rs9305046, rs2045912, rs17275290, rs10419425, rs2524359, rs41360944, rs8105431, rs16980016, rs10518246, rs1290624, rs718258, rs2886474, rs10518252, rs1558139, rs10518254, rs4442930, rs4808025, rs745811, rs3826721, rs12710303, rs285233, rs3752797, rs2262138, rs4299271, rs728117, rs17029, rs754292, rs773901, rs16981567, rs7259348, rs17527173, rs10423232, rs10424129, rs12984915, rs4450527, rs2375636, rs3848643, rs7254508, rs10418441, rs16981892, rs10416963, rs952609, rs4808957, rs10500212, rs765051, rs836896, rs808372, rs4932976, rs2033494, rs1692597, rs10422124, rs892049, rs289296, rs421458, rs295403, rs1038142, rs1842221, rs10500221, rs6511593, rs4932927, rs723352, rs10500222, rs17206080, rs9305015, rs6511686, rs1821303, rs10500233, rs724637, rs4806230, rs4804845, rs6508962, rs9304626, rs6509109, rs16962344, rs950024, rs1433114, rs7248438, rs10516718, rs10500237, rs10518258, rs9304664, rs877836, rs10853820, rs4805443, rs1048123, rs7250389, rs966462, rs12972995, rs9630882, rs8111792, rs10405711, rs1821274,

rs33430, rs1030687, rs965945, rs2195956, rs892095, rs2867469, rs1604432, rs1077644, rs7343067, rs1846999, rs10425253, rs2903611, rs1580756, rs10425081, rs2867574, rs1074607, rs10518285, rs278275, rs10415954, rs16966885, rs12985626, rs2868083, rs1468496, rs10500261, rs1862214, rs2903752, rs7250780, rs8112647, rs7247748, rs1981818, rs11881580, rs8101468, rs16967984, rs8103773, rs3786922, rs529579, rs10500271, rs682977, rs629018, rs16969156, rs1669261, rs379862, rs10500273, rs10500275, rs967987, rs888861, rs720309, rs2432055, rs2972533, rs4806292, rs2271844, rs17206393, rs2912422, rs7254360, rs3108167, rs2909109, rs856300, rs241958, rs3894129, rs705495, rs16978759, rs833923, rs12462587, rs3745945, rs4803284, rs10409279, rs7248018, rs1053686, rs10853730, rs12052169, rs4490097, rs4803330, rs1981958, rs4622626, rs4803342, rs17656504, rs2241713, rs1473248, rs10407348, rs8107333, rs16975329, rs2317314, rs1860256, rs929502, rs2109075, rs10500285, rs9304608, rs2353125, rs2159027, rs9304618, rs2355416, rs7249791, rs2190843, rs11083698, rs12976706, rs2682578, rs2261316, rs2854508, rs1402326, rs3046, rs4251855, rs4802190, rs346522, rs670950, rs10500286, rs16976816, rs239943, rs1073653, rs462723, rs9304639, rs984117, rs2571081, rs204541, rs644148, rs718087, rs11670955, rs17727898, rs846848, rs1661197, rs3760626, rs10417618, rs6509200, rs346750, rs345419, rs11879934, rs2116891, rs16979989, rs3760843, rs8106841, rs4803866, rs10500293, rs2216346, rs1990765, rs1989583, rs10153467, rs8100021, rs12459321, rs4803953, rs6509283, rs3848534, rs311365, rs2341877, rs10518277, rs1019786, rs16981560, rs274875, rs2008521, rs10500300, rs17295412, rs10401192, rs10405073, rs2638283, rs41347145, rs3826818, rs1175804, rs171342, rs3826718, rs3786567, rs731826, rs17668162, rs6509448, rs12609054, rs10500303, rs9304701, rs582078, rs1559133, rs1506684, rs1654520, rs9304710, rs6509546, rs4802803, rs2124909, rs11084095, rs11084109, rs11667868, rs8100600, rs41497444, rs329939, rs2617795, rs10401904, rs12980672, rs11084178, rs10853854, rs7252818, rs9304745, rs1293700, rs1865046, rs3902016, rs950798, rs10500316, rs4022320, rs741584, rs10426462, rs8109349, rs11084341, rs3813148, rs11672056, rs6509880, rs1469335, rs2241524, rs3843752, rs10411948, rs3729841, rs553947, rs11882031, rs2287832, rs17634917, rs299165, rs7258501, rs2074941, rs3752180, rs10403522, rs10416972, rs1080049, rs12462745, rs9967637, rs1055359, rs2870477, rs8102497, rs1368467, rs892167, rs2361128, rs862703, rs6510084, rs11084504, rs10410631, rs2885007, rs964795, rs10518271, rs2229375, rs260424, rs260445, rs260454, rs260472, rs11084544, rs3794970, rs11669127, rs6510156, rs7249714, rs4814683, rs6055084,

rs6109597, rs2077713, rs6037460, rs10485820, rs4813750, rs1114734, rs2317024, rs6140882, rs6086841, rs651329, rs4813115, rs1294690, rs10485823, rs715217, rs2246154, rs1438106, rs202520, rs1347741, rs593095, rs1012780, rs127903, rs2206698, rs10485703, rs7269557, rs4814966, rs4239736, rs6082408, rs1610302, rs3895160, rs84825, rs10485600, rs1008405, rs6083460, rs1810636, rs2875803, rs6084154, rs6132976, rs6084231, rs999409, rs1056881, rs4611719, rs2236122, rs16988566, rs235577, rs235519, rs6115970, rs2326369, rs16989217, rs6052350, rs1741344, rs835882, rs6084677, rs8123338, rs6116326, rs531043, rs4141626, rs2326536, rs1981105, rs16989992, rs12625444, rs7264576, rs968432, rs6116566, rs1715372, rs12625764, rs6107609, rs927103, rs6116754, rs10485486, rs10485489, rs6085231, rs805751, rs16991606, rs6139898, rs6085382, rs16991821, rs6038520, rs1411296, rs2423161, rs1576448, rs6107847, rs967417, rs4456770, rs235713, rs2224191, rs723511, rs6140226, rs724084, rs2224053, rs2326931, rs6086141, rs6086149, rs2143197, rs6140387, rs2423290, rs2423311, rs2205824, rs2223276, rs941426, rs2229895, rs10485741, rs3790158, rs7269017, rs6040067, rs6077869, rs2327327, rs2144148, rs6040435, rs6040484, rs982210, rs715370, rs9305124, rs6041636, rs433279, rs360526, rs6109675, rs6033617, rs6134850, rs6042222, rs6042313, rs6042334, rs65567, rs6043088, rs17272483, rs10485517, rs4813172, rs458032, rs6079817, rs8121515, rs6034213, rs10485530, rs6110695, rs463020, rs10485558, rs926773, rs10485559, rs6105644, rs3761296, rs10485562, rs7274195, rs6135981, rs964957, rs852105, rs2208199, rs6080717, rs2235586, rs6034860, rs6111621, rs725711, rs10485573, rs6105861, rs6105916, rs2273525, rs6045491, rs6045570, rs6132107, rs731667, rs10485587, rs874468, rs6514960, rs1074615, rs3790209, rs6046148, rs2328411, rs3790272, rs728173, rs2145104, rs808704, rs927113, rs6046326, rs10485595, rs199577, rs16981473, rs6046575, rs1040564, rs2273123, rs2424300, rs6112858, rs3748446, rs6137130, rs1536340, rs953363, rs963487, rs6082269, rs2145966, rs8120377, rs763798, rs1546996, rs202838, rs2424376, rs2328682, rs201561, rs422913, rs2424475, rs1338945, rs844867, rs2096253, rs6137917, rs2281428, rs2983301, rs16985458, rs10485645, rs1884861, rs3901412, rs2071443, rs4815252, rs6114415, rs761870, rs7268544, rs487665, rs2206648, rs10485832, rs722834, rs1326298, rs6049811, rs226693, rs1029033, rs727964, rs1985485, rs2387577, rs2224072, rs8115729, rs3787078, rs2387881, rs402120, rs8120594, rs11906382, rs1811868, rs2379750, rs6060436, rs1474945,

rs6058491, rs4911202, rs6057603, rs721220, rs1484998, rs6119651, rs10485497,

rs1205843, rs10485498, rs17293048, rs242535, rs6059183, rs291700, rs6120314, rs6120328, rs17124851, rs2626555, rs2626536, rs742614, rs6120487, rs1205350, rs6088728, rs2069940, rs6060341, rs6060435, rs6060526, rs11907811, rs6121100, rs6121201, rs2057145, rs1146251, rs717599, rs6126457, rs4811354, rs6022147, rs8122010, rs6097732, rs10485481, rs4809987, rs1780615, rs6123629, rs11536959, rs805556, rs6015693, rs2144538, rs10485651, rs731459, rs6028156, rs4812348, rs16987827, rs6028762, rs2223745, rs4142394, rs1018389, rs4810321, rs6072427, rs2143233, rs10485680, rs3091599, rs6029839, rs6029893, rs4812571, rs6102688, rs761011, rs6030435, rs6030447, rs6103041, rs208243, rs4812655, rs6130232, rs1397853, rs926293, rs6103249, rs6103265, rs6124562, rs4810385, rs2867725, rs619289, rs3127065, rs6124593, rs10485701, rs6017247, rs1040546, rs10485702, rs2269598, rs2425648, rs244090, rs2868116, rs2868161, rs12481468, rs6017513, rs6032344, rs4810480, rs6094286, rs465431, rs6066122, rs6063050, rs3787265, rs1417450, rs2903925, rs6066324, rs4809636, rs12480081, rs10485463, rs6018630, rs1591168, rs1815969, rs2426052, rs852341, rs852350, rs10485606, rs421630, rs6019015, rs6095069, rs6063312, rs2180982, rs6066975, rs6122763, rs237475, rs803193, rs6125758, rs17786105, rs2235617, rs944932, rs6091131, rs6122964, rs230032, rs7270033, rs6067689, rs6067704, rs6067803, rs2273090, rs6126321, rs17793245, rs6096689, rs6091499, rs6096889, rs2904155, rs4811337, rs2078577, rs4811374, rs2247273, rs2256452, rs1936958, rs10485451, rs200641, rs10485447, rs16998010, rs3748501, rs10485443, rs6022863, rs7272436, rs6091785, rs458990, rs209960, rs2616277, rs1555439, rs10485794, rs292123, rs4811500, rs41398245, rs2180462, rs2143708, rs6014159, rs2065042, rs1016884, rs6023940, rs4493333, rs2870619, rs211922, rs6092111, rs214389, rs2770377, rs1437211, rs6024612, rs6092248, rs10485804, rs16979664, rs6127723, rs1047972, rs8125124, rs2870758, rs6025096, rs6014814, rs10485807, rs1276336, rs230206, rs162315, rs10485809, rs2865382, rs4811868, rs6025653, rs4239677, rs205794, rs326832, rs10485811, rs6026023, rs614507, rs3761258, rs6026674, rs171839, rs2053780, rs6064822, rs6128657, rs1980599, rs1182484, rs746219, rs10485817, rs10485464, rs10485466, rs6092877, rs1201879, rs2144880, rs10485470, rs2017286, rs2024677, rs6101183, rs6129032, rs817686, rs1970546, rs1328760, rs1001583, rs2225224, rs1112041, rs1740362, rs6121489, rs6089701, rs3088238, rs8122282, rs708629, rs3746765, rs2295001, rs2427462, rs2277769, rs1406961, rs3787131, rs10485825, rs186332, rs2777938, rs6089982, rs816937, rs6011286, rs573217, rs6512308, rs2427625,

rs17491728, rs10485816, rs4293623, rs457323, rs2847443, rs2801294, rs3869758, rs4036510, rs2821826, rs3117284, rs432575, rs469000, rs3892597, rs2262214, rs1888394, rs2822302, rs2822335, rs423169, rs2110153, rs11911176, rs2823041, rs10482868, rs2823172, rs10482876, rs434246, rs373182, rs2823525, rs2823527, rs9305760, rs2823736, rs2823738, rs7278719, rs239021, rs2823753, rs3737408, rs2823895, rs2018708, rs7283241, rs2154727, rs7364073, rs9979358, rs2824571, rs149786, rs440624, rs4818400, rs2824643, rs2824702, rs2824720, rs2824751, rs2824809, rs978422, rs426803, rs7281316, rs10482900, rs2825470, rs2825513, rs2825531, rs2825546, rs2825568, rs2825583, rs2825601, rs2825610, rs555174, rs2244367, rs2825673, rs2825681, rs2825713, rs2825745, rs952125, rs468280, rs10482909, rs2826366, rs2826450, rs2826879, rs2827012, rs2027715, rs2226657, rs2017712, rs189900, rs9680422, rs17572439, rs1040086, rs2828492, rs2829252, rs2829282, rs2051276, rs2829741, rs2829750, rs2829787, rs1783012, rs2829811, rs2829843, rs2154471, rs2829874, rs2829961, rs2830031, rs731524, rs2830092, rs469220, rs462840, rs2830182, rs219676, rs219664, rs2830244, rs222972, rs222949, rs2830322, rs9984081, rs229042, rs229093, rs162526, rs233598, rs13048092, rs2830660, rs235925, rs1376922, rs239724, rs242326, rs242310, rs10482985, rs10482986, rs2831057, rs2831617, rs2831700, rs2409302, rs719025, rs10482990, rs2832073, rs1048546, rs2832153, rs4817276, rs2249140, rs455683, rs2833312, rs4816397, rs11700615, rs2833462, rs7280442, rs11700761, rs9982003, rs2833846, rs2833864, rs2833867, rs1015047, rs844998, rs10483014, rs2013329, rs2834010, rs2834036, rs2834076, rs2409470, rs2252639, rs8178522, rs17644622, rs1044218, rs2211793, rs11088274, rs1119396, rs8134365, rs2247946, rs2834402, rs9284457, rs16991374, rs2834428, rs2834448, rs723548, rs10483018, rs2834495, rs7280739, rs2300391, rs12482676, rs766427, rs2154444, rs2834596, rs975297, rs2834929, rs2142101, rs2835154, rs2835173, rs915742, rs2835214, rs2835229, rs2835248, rs2835287, rs885808, rs1573305, rs2246810, rs7280997, rs10854376, rs9978611, rs395383, rs377239, rs914147, rs2000548, rs1984020, rs10483036, rs2245353, rs2836168, rs2836222, rs10483043, rs928772, rs2065306, rs2836328, rs2836400, rs10483044, rs2836466, rs2836805, rs760152, rs2037922, rs2836933, rs2836941, rs2836966, rs7275773, rs2836974, rs7281853, rs2776307, rs2836994, rs2837100, rs10483055, rs2837115, rs10483058, rs4816657, rs2837258, rs1011037, rs720566, rs2837367, rs2249498, rs2410212, rs451518, rs2837452, rs2410218, rs2837574, rs10483070, rs2837813, rs2837821, rs1012854, rs988630, rs744549, rs2837965,

rs914183, rs2837997, rs183436, rs3788010, rs2839511, rs10483087, rs1399925, rs10483088, rs2269128, rs2300957, rs2839569, rs12626774, rs1029332, rs967445, rs2839590, rs1009829, rs234693, rs2212838, rs2838242, rs501228, rs162367, rs162400, rs10483077, rs1598206, rs1537118, rs6518340, rs2277805, rs2838534, rs235288, rs2838681, rs9637166, rs453176, rs2838845, rs2838886, rs9637198, rs2838917, rs10483080, rs10483081, rs725930, rs420270, rs2839168, rs2839210, rs9980536, rs2839235, rs2839281, rs2330591, rs2070435, rs2839315, rs9983698, rs9722, rs9984765, rs2839367, rs10483083, rs9306194, rs10483095, rs2401169, rs2075446, rs9618586, rs5746770, rs6518565, rs13055644, rs455049, rs2269724, rs175162, rs16982973, rs175200, rs9605086, rs737811, rs165889, rs2014654, rs2269833, rs2098295, rs400946, rs181360, rs861817, rs7284924, rs2099792, rs1016548, rs7288332, rs5756725, rs5756727, rs6519111, rs5750467, rs7291954, rs5756807, rs2876995, rs2014748, rs5995601, rs11574468, rs1541312, rs5758009, rs10483112, rs9306362, rs715591, rs2854097, rs10483114, rs10483115, rs882512, rs6519411, rs1807460, rs762601, rs10483116, rs140154, rs7290879, rs140152, rs4822418, rs17543753, rs140156, rs2330578, rs2877178, rs176157, rs5751838, rs1041748, rs3896622, rs5760590, rs41458046, rs5760596, rs6004247, rs5996751, rs5751975, rs139652, rs737769, rs139753, rs5760748, rs17668150, rs2008244, rs6004433, rs713989, rs5760932, rs10483119, rs10483120, rs4820649, rs10483121, rs505497, rs12158587, rs16980525, rs5761162, rs134710, rs2205980, rs2223338, rs17299838, rs3747129, rs10483126, rs9306427, rs9306430, rs5761848, rs5761875, rs6005257, rs2007727, rs13055147, rs4820736, rs5761963, rs5752494, rs8143105, rs543123, rs569626, rs10483135, rs5762164, rs7290269, rs1885359, rs715559, rs738451, rs720621, rs10483141, rs10483144, rs10483145, rs134187, rs9306454, rs10483148, rs1297607, rs738199, rs10483149, rs465736, rs5763240, rs5763241, rs13340033, rs13053817, rs174649, rs165734, rs16987928, rs2530678, rs2267151, rs1009147, rs5753152, rs11089450, rs4820849, rs4820851, rs5749102, rs2072196, rs737952, rs7364237, rs4820018, rs5753220, rs4820869, rs16988803, rs140078, rs10483161, rs4820997, rs3747158, rs4821018, rs5998221, rs10483163, rs5753878, rs136458, rs1467388, rs738202, rs1961908, rs7286017, rs2294311, rs2076045, rs715542, rs739008, rs739104, rs5754223, rs2899194, rs10483165, rs25112, rs78506, rs10483168, rs1981469, rs7292645, rs713697, rs5998768, rs9306274, rs2001070, rs5998889, rs715487, rs8141158, rs5999013, rs5749679, rs130461, rs10483176, rs2019466, rs204434, rs10483177, rs4820149, rs2103554, rs5749913, rs10483185, rs8139897,

rs10483186, rs10483187, rs713708, rs362019, rs134410, rs713819, rs10483192, rs6000040, rs10483193, rs713929, rs1557540, rs739096, rs739097, rs9607337, rs136213, rs713797, rs933224, rs2294357, rs2076083, rs5750269, rs140022, rs7284729, rs9622421, rs738977, rs2252055, rs715582, rs5750303, rs4820261, rs5995370, rs10483196, rs5756540, rs16997923, rs13053175, rs4821623, rs5756601, rs1981476, rs1008184, rs2899293, rs713991, rs196105, rs5757091, rs10483198, rs126230, rs5750816, rs5757659, rs6001585, rs17001093, rs7292457, rs713865, rs5995756, rs136817, rs5750871, rs17001426, rs5995773, rs7291427, rs6001679, rs5757798, rs3021213, rs6001911, rs12157495, rs17001993, rs9607730, rs17002034, rs133054, rs12168697, rs6519257, rs12157559, rs9619990, rs8190407, rs135095, rs130388, rs5764280, rs16991000, rs7291445, rs738494, rs7289308, rs16991369, rs5766418, rs138603, rs738361, rs6007211, rs5764957, rs132450, rs1557558, rs1001728, rs7289868, rs41441149, rs136687, rs10483224, rs9306489, rs226524, rs738177, rs2014661, rs713896, rs2337049, rs9616036, rs5767240, rs4823849, rs3788727, rs5767385, rs4431, rs5767968, rs7292036, rs5768001, rs5768271, rs133633, rs713923, rs6520008, rs739155, rs131958, rs12158344, rs13055655, rs13054888, rs10212077, rs34189568, rs13054207, rs6009503, rs7288176, rs2091051, rs17245306, rs17245482, rs10483246, rs7292943, rs860236, rs1807472, rs738415, rs10483250, rs4624, rs713809, rs909693, rs7364173, rs6009921, rs5770916, rs3091400, rs6009945, rs8135777, rs9628187, rs6608411, rs6603172, rs11019, rs1140798, rs6603201, rs7472503, rs5950843, rs5950775, rs5950790, rs4911922, rs3995646, rs4078358, rs7066322, rs1470876, rs1349787, rs2045059, rs6588897, rs7061181, rs1921964, rs17842863, rs1343925, rs5939084, rs5982788, rs2316853, rs311060, rs311063, rs5939342, rs10522044, rs5983044, rs5982666, rs2694742, rs2704864, rs5939515, rs12391688, rs12398801, rs1038342, rs5916402, rs5916449, rs5916481, rs6639933, rs16992231, rs5916702, rs10081857, rs16997514, rs1921946, rs16984757, rs6640068, rs16985029, rs16992194, rs7064826, rs6654876, rs5933676, rs1236387, rs741500, rs7357916, rs7882261, rs7063844, rs10521613, rs12014127, rs2238910, rs5979959, rs6633319, rs16979182, rs16979187, rs2283707, rs5935816, rs764990, rs798180, rs798168, rs4830998, rs2040722, rs11094730, rs6632983, rs12836443, rs7878756, rs6633014, rs12557777, rs17274190, rs17274225, rs4342750, rs17320935, rs7876407, rs12012448, rs763051, rs10465354, rs4825231, rs3788809, rs7877399, rs7055605, rs16981096, rs5955761, rs1042456, rs12010722, rs7892835, rs6418737, rs4129871, rs5909364, rs5955898, rs41388452, rs4824213, rs16981696, rs732946, rs7891381, rs5951678,

rs2071201, rs6629448, rs9306764, rs5904511, rs16981858, rs5951738, rs7891653, rs4828840, rs5926022, rs2002062, rs2051845, rs7065749, rs7883926, rs5944691, rs17217647, rs1212068, rs5944611, rs5944633, rs5926904, rs1351260, rs6526585, rs5926561, rs6630351, rs5926659, rs221408, rs5971410, rs221373, rs2012966, rs1012186, rs2001510, rs5971488, rs16989088, rs12014280, rs12010301, rs728149, rs5972213, rs10522011, rs10522016, rs4829129, rs10522018, rs5928154, rs4829131, rs2897445, rs10522020, rs3910698, rs4829160, rs1571475, rs2204667, rs10522033, rs10522034, rs1344031, rs5973634, rs5929034, rs9284567, rs1541165, rs1393533, rs10521418, rs4827147, rs206037, rs958642, rs4472657, rs6610585, rs4986505, rs5952688, rs1207315, rs5906072, rs12558883, rs6609614, rs11091237, rs3027475, rs6520412, rs3761547, rs41513244, rs5906782, rs7060479, rs5953333, rs1997608, rs5915254, rs2382659, rs41493148, rs2382920, rs1276800, rs5945596, rs4457126, rs1992271, rs4131729, rs942926, rs1409117, rs7880223, rs6638366, rs721003, rs17002591, rs5914323, rs942846, rs1332730, rs5960186, rs5914799, rs10521485, rs10521486, rs2116364, rs717848, rs2060113, rs2043183, rs2982263, rs2982255, rs5961017, rs5961031, rs2227151, rs5989026, rs4571900, rs6521663, rs2179580, rs2206164, rs6612882, rs6624652, rs5964719, rs3892372, rs16990512, rs17301157, rs2092459, rs6524883, rs7878693, rs10521490, rs6653202, rs7059376, rs649946, rs1601458, rs521362, rs938058, rs5919287, rs2221799, rs10521339, rs5980854, rs6653263, rs5980736, rs16990746, rs7887530, rs2214067, rs17174152, rs16992436, rs5982487, rs1620574, rs16992443, rs1009948, rs1894271, rs17312542, rs538732, rs511721, rs4892511, rs4892385, rs16991762, rs6647531, rs16991813, rs2798171, rs6647074, rs6647579, rs6647582, rs7052314, rs2181550, rs9887743, rs5937392, rs11796028, rs4826225, rs743074, rs4826262, rs3027544, rs3027550, rs2013015, rs10521358, rs2227291, rs17139617, rs6622665, rs17139585, rs2284753, rs4826248, rs717689, rs2073178, rs2063579, rs16979519, rs6616697, rs3106407, rs17281713, rs12688645, rs16980111, rs2032572, rs6653047, rs17004159, rs12557215, rs12012004, rs6653069, rs6653071, rs7066658, rs5923573, rs2858684, rs1845306, rs17279128, rs4240069, rs12391207, rs11797296, rs1987332, rs1402079, rs10126690, rs7890975, rs213698, rs12013210, rs2782710, rs6619783, rs5949671, rs233655, rs7877636, rs877358, rs1204408, rs17329105, rs2022475, rs4828039, rs1057403, rs2071223, rs3027641, rs3027615, rs2238984, rs2238982, rs3027588, rs1023431, rs5944869, rs6621219, rs7886058, rs5945088, rs5945089, rs5944873, rs5945908, rs87951, rs7057844, rs5987554, rs17340370, rs2239814, rs510819, rs1407804, rs5962948,

rs7890281, rs4826961, rs5916789, rs2344911, rs2064722, rs3788922, rs1563315, rs1936495, rs1936492, rs5942793, rs10521523, rs615213, rs484369, rs10521525, rs5943394, rs4129094, rs5942852, rs2106685, rs4421522, rs6642761, rs10521529, rs1538181, rs1556804, rs1856514, rs1339301, rs5985590, rs16986439, rs1156613, rs17222328, rs7880069, rs16986482, rs5943145, rs4893490, rs5190, rs16994864, rs1933688, rs2336396, rs2041633, rs16992817, rs2048637, rs7892463, rs2496203, rs17261236, rs2239963, rs17327123, rs16995673, rs2428212, rs1800823, rs1541341, rs2285553, rs10127182, rs8160, rs5957385, rs14410, rs42896, rs16995860, rs6603633, rs2285549, rs12396563, rs12393998, rs2106543, rs12007747, rs2157272, rs16997304, rs682478, rs503118, rs35601010, rs12164382, rs5956646, rs7054346, rs1883252, rs17304776, rs2076076, rs6529391, rs7065704, rs41482049, rs1538973, rs5932692, rs10521757, rs12007681, rs2275604, rs3764771, rs17000937, rs5933109, rs5977655, rs6637998, rs1866940, rs1441624, rs17277749, rs7052366, rs17251516, rs926596, rs2267519, rs1150185, rs17000619, rs17324664, rs6634993, rs12007717, rs6654310, rs12689820, rs978789, rs7881802, rs12012108, rs10126722, rs4439284, rs5974618, rs5930985, rs4829846, rs2306223, rs5931174, rs17001833, rs4825223, rs367697, rs7064707, rs5955457, rs458668, rs6634158, rs2208255, rs203644, rs16979898, rs12689545, rs11797945, rs1120947, rs5907189, rs16979902, rs12389918, rs5955057, rs851100, rs2719868, rs7063331, rs5951757, rs5980399, rs10449049, rs6649480, rs4111115, rs9803181, rs5970097, rs722351, rs16996206, rs10521896, rs1844894, rs1009387, rs5970304, rs6526113, rs6627606, rs3088344, rs10521897, rs10521898, rs6627785, rs6627788, rs928952, rs4328010, rs5987201, rs2239468, rs5945195, rs4898348, rs5945109, rs5945122, rs1448032, rs895744, rs41362344, rs547956, rs693771, rs35296872, rs6420603, rs5940513, rs479901, rs672932, rs4518813, rs2075640, rs17276393, rs34742138, rs9786252, rs2134267, rs3962903, rs2882458, rs450234, rs4099885, rs4030616, rs2573946, rs4029075, rs4029051, rs4028931, rs17276777, rs4028041, rs4028025, rs7067316, rs4121530, rs768983, rs16981311, rs3096835, rs4589048, rs9786105, rs7892900, rs17250740, rs9786904, rs9786279, rs1367252, rs1864469, rs895530, rs17250803, rs9786291, rs9785740, rs3901597, rs9786140, rs17250887, rs11096453, rs957431, rs13305612, rs9786194, rs4119074, rs11096435, rs13304447, rs17306657, rs17316007, rs17306671, rs4141886, rs9786819, rs17269396, rs17306762, rs13304202, rs9786712, rs13304168, rs9786634, rs9786191, rs2032595, rs2032596, rs2032598, rs34790845, rs2032605, rs9786043, rs9786581, rs891234, rs1971755, rs17222244, rs16980457, rs9786824, rs17222412, rs7067512,

rs35516764, rs9786479, rs16980391, rs7067458, rs16980396, rs17315912, rs1833407, rs966239, rs1479913, rs17250114, rs17250121, rs16980401, rs9786101, rs11096432, rs11096433, rs3904, rs3900, rs2032621, rs4116821, rs16980561, rs7893064, rs17323322, rs34194308, rs17250535, rs9785974, rs3859997, rs1276034, rs4025796, rs3951517, rs324937, rs9786095, rs9786258, rs17316910,

Otra realización preferida del segundo aspecto de la invención se refiere al método donde la enfermedad genética es cáncer o una enfermedad congénita. Preferentemente el cáncer es cáncer del sistema nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemia linfática crónica, leucemia linfática aguda, mieloma múltiple o un síndrome mielodisplásico. Más preferentemente el cáncer del sistema nervioso central es glioma (bajo y alto grado), meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme. Preferentemente la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.

Una realización preferida del método primero o del método segundo de la invención se refiere al método donde la detección de la ganancia y/o pérdida cromosómica se realiza mediante hibridación con sondas de ácido desoxirribonucleico (ADN). Preferentemente el número de sondas se sitúa entre 10.000 y 20.000 sondas diferentes, más preferentemente el número de sondas se sitúa entre 14.000 y 15.000 sondas diferentes. En otra realización aún más preferida las sondas tienen entre 20 y 200 pares de bases (pb). Las sondas pueden ser sondas polimórficas o sondas no polimórficas. El término “sondas polimórficas” se refiere a sondas que detectan polimorfismos del tipo “single nucleotide polymorphism” o SNP. Por lo tanto, una realización aún más preferida del método primero o del método segundo de la invención se refiere a los métodos donde las sondas detectan al menos un polimorfismo genético, preferiblemente detectan los polimorfismos señalados en la tabla 2. Las sondas no polimórficas detectan material genético que no comprende polimorfismos. Las sondas pueden estar repetidas.

El término “polimorfismo genético” se refiere a una variación en la secuencia de nucleótidos de la cadena de ácido desoxirribonucleico (ADN o DNA, “desoxirribonucleic acid”) que tiene al menos una frecuencia del 1% en los individuos

de una población. Los polimorfismos genéticos pueden ser variaciones de uno o varios nucleótidos. El polimorfismo de un solo nucleótido, “single nucleotide polymorphism” o SNP, generalmente da lugar a dos alelos distintos. Los SNPs o polimorfismos pueden contener información sobre la variación de un solo polimorfismo o la información de un haplotipo si son SNP etiquetas o “tag-SNP”. En la presente invención los términos “polimorfismo” y “SNP” se utilizan de manera indistinta.

Los polimorfismos Tag-SNPs son polimorfismos marcadores de una región genómica que se encuentra dentro de un determinado bloque haplotípico. Cualquier variante genética que se encuentre dentro del mismo bloque haplotípico que los Tag-SNPs se heredará conjuntamente con éstos con una alta probabilidad. Es decir, los polimorfismos dentro de un bloque haplotípico están en desequilibrio de ligamiento (de Bakker, P.I.W., y cols. 2005. Nature Genetics, 37(11):1217-1223).

En la presente invención nos referimos a “haplotipo” como un conjunto de polimorfismos (SNPs) que se heredan en bloque.

Los términos “polinucleótido”, “secuencia nucleotídica”, “secuencia de nucleótidos”, “ácido nucleico” y “oligonucleótido” se usan aquí de manera intercambiable, y se refieren a una forma polimérica de nucleótidos de cualquier longitud, que pueden estar, o no, química o bioquímicamente modificados.

Otra realización aún más preferida se refiere a los métodos donde las sondas se sitúan en un soporte sólido. Los soportes sólidos que se pueden utilizar son los conocidos por el experto en la materia, por ejemplo vidrio, nitrocelulosa o nylon.

Con el método de la invención, se puede realizar el análisis de no sólo una única muestra, sino de varias muestras en un mismo soporte sólido debido a la menor densidad (se pueden incluir varias muestras entre 2 a 10 pacientes en un mismo soporte o portaobjetos) pero manteniendo la capacidad de análisis global del genoma, siendo posible el análisis de cada muestra de forma individual. La presente invención constituye por lo tanto una mejora y una simplificación con respecto a los métodos conocidos hasta ahora.

Las sondas se pueden modificar posteriormente a su fijación al soporte sólido mediante la adición de fluorocromos o moléculas quimioluminiscentes por los métodos conocidos por cualquier experto en la materia. Por este motivo, otra realización aún más preferida del método primero y segundo de la invención se refiere a ambos métodos donde las sondas están marcadas con fluorocromos, por ejemplo como biotina, estreptavidina-ficoeritrina.

El término “hibridación”, tal y como se utiliza en la presente descripción, se refiere al apareamiento de dos moléculas de ADN de cadena simple complementarias para dar una molécula de doble cadena. Preferiblemente, la complementariedad es del 100%. Esto es, en la región de complementariedad cada nucleótido de una de las dos moléculas de ácido nucleico puede formar enlaces de hidrógeno con un nucleótido presente en la otra molécula de ácido nucleico. Sin embargo, aquéllos con una experiencia normal en el campo reconocerán que dos moléculas de ácido nucleico que posean una región con complementariedad menor al 100% también pueden hibridar.

El término “nucleótido”, tal y como se utiliza en la presente descripción se refiere a un molécula orgánica formada por la unión covalente de una pentosa, una base nitrogenada y un grupo fosfato. El término nucleótido incluye desoxirribonucleósidos trifosfato como, por ejemplo, pero sin limitarse, dATP, dCTP, dITP, dUTP, dGTP, dTTP, o derivados de los mismos. El término nucleótido incluye también dideoxirribonucleósidos trifosfato (ddNTPs), como por ejemplo, ddATP, ddCTP, ddGTP, ddITP, ddTTP o derivados de los mismos.

De acuerdo con la presente invención un “nucleótido” puede ser marcado o etiquetado mediante técnicas bien conocidas en el estado de la técnica. Etiquetas detectables incluyen, por ejemplo, isótopos radiactivos, etiquetas fluorescentes, etiquetas quimioluminiscentes, etiquetas bioluminiscentes o etiquetas enzimáticas.

Las sondas deben respetar las posiciones físicas que se muestran la tabla 3 en cada cromosoma, con un intervalo de ± entre 80 a 200 pares de bases (es decir que la distancia entre una sonda y otra similar es de 100 pares de bases). Las posiciones físicas se señalan a continuación (“Cr” se refiere a “cromosoma”):

Tabla 3. Posiciones físicas que deben cubrir las sondas empleadas en el array con un intervalo de más menos 200pb (Cr.: cromosoma).

Cr1:564477,721290,740857,846864,1003629,1097335,1130727,1156131,1211292,13 65570,1506035,1663831,1721479,1753686,1793786,1888369,2027901,2047584,223 4251,2283313,2302911,2452569,2505713,2546229,2723552,2754406,2793232,2841 880,2925539,2973576,2996196,3025712,3095126,3127137,3165267,3188143,32372 09,3278959,3377343,3420135,3474777,3545612,3655536,3681681,3694647,374331 9,3792801,4003894,4066680,4116604,4171786,4315204,4340991,4377032,4521736, 4580135,4586606,4652005,5312165,5493392,5582558,5612956,5709833,5743737,5 750582,5785135,5817265,5904744,6042934,6103047,6177202,6211964,6343825,63 44153,6360147,6376222,6395591,6501796,6530189,6548056,6568950,6651728,670 9610,6764643,6768856,6817343,6936272,6990491,7055326,7314529,7361338,7391 983,7429092,7770132,7812398,7961206,8032576,8066914,8079301,8100140,81192 62,8242487,8372536,8468372,8495590,8598005,8629380,8808185,8828250,885710 4,8918313,9285721,9300747,9427796,9431223,9489406,9538654,9556061,9647137, 9677002,9733221,9771564,9900163,9923741,9964708,9973928,10027540,10155283 ,10286358,10308631,10338598,10420918,10459779,10509703,10544725,10555257, 10749197,10832861,10867074,10956645,11009543,11029478,11060075,11093741,1 1129259,11151314,11181985,11248237,11278163,11293792,11567190,11607224,11 613163,11633982,11727678,11831615,11879267,12046089,12218812,12281273,123 29295,12458797,12488475,12559766,12615069,12836442,12852872,12854530,1291 0136,12998268,13488491,13775026,13793392,13837629,13859570,13920167,13948 765,14117876,14150032,14386963,14388300,14495003,14577474,14620369,148046 54,14805993,14849088,14857643,14870568,14888753,14901191,14934220,1510605 7,15140362,15206049,15234029,15288789,15354296,15377554,15548673,15566349 ,15631649,15635500,15841742,15860803,15900517,15920454,16255644,16279386, 16585818,16619350,16665608,17029714,17359676,17412501,17569949,17611288,1 7744852,18475441,18611016,18678758,18707373,18803022,18881980,19032248,19 049946,19215418,19365346,19471388,19499835,19564846,19590393,19614064,197 33255,19769371,19808828,19843576,19876025,19899537,19945857,19973920,2000 8880,20615501,20865703,20866735,20893965,21100916,21155195,21213367,21324 933,21355220,21374810,21396886,21821757,21840709,21880068,22068259,221100 72,22147077,22208864,22475816,23096818,23299906,23301943,23338899,2337192

1,23409538,23435538,23504795,23606001,23688178,23746625,23845288,23997195 ,23998136,24025181,24053465,24148988,24335967,24385330,24406647,24476370, 24639413,24705688,25337587,25402705,25570830,25623967,25628073,25688276,2 5717308,25753638,25892880,25936250,26053997,26106769,26144545,26171473,26 358202,26535146,26801290,27327432,27475489,27556381,27628545,27728040,278 49300,27872827,27931698,27960011,29345027,29385486,29477472,29579157,2958 0348,29620756,29655746,29868794,30061852,30232687,30373814,30420739,30465 852,30521571,30619406,30710855,30739134,30862620,31099929,31147858,313114 18,31722166,31736800,31833706,31855474,31883475,31909124,31973873,3199387 0,32168879,32378540,33136120,33247797,33324136,33408138,33888370,33937135 ,33945685,33968896,34002142,34046034,34071898,34205859,34225784,34250446, 34265969,34267707,34282417,34332933,34396943,34479434,34523870,34574691,3 4605279,34659609,34916121,35057999,35079328,35150174,35185845,35646125,35 862656,35923471,36118089,36404949,36443569,36497349,36551895,36601368,367 54467,36818066,36937614,37001212,37021076,37041069,37174773,37240038,3725 6063,37278577,37725041,37782874,37958813,38046920,38189142,38507495,38639 208,38666914,38733788,38816241,38885449,38919423,38936584,38967983,390099 96,39029775,39120658,39164153,39322323,39358143,39387607,39406644,3942548 9,39503878,39551242,39620619,39643382,39678990,39719519,40594472,40657449 ,40702570,40733658,40761848,40799989,40847491,40864296,41225520,41231424, 41270163,41386871,41538787,41619894,41702186,41783873,41864364,41881922,4 2008521,42033410,42054782,42082452,42301301,42360713,42465728,42517167,42 666646,42777024,42962221,42999787,43049903,43073464,43158510,43163546,432 15178,43299121,43357600,43406154,43508705,43616753,43669055,43720994,4382 5644,44237465,44390392,44530354,44771485,44856843,44885922,44954764,44988 433,45006764,45060687,45358527,45431617,45466511,45585348,45635802,456659 39,45697068,45748381,45791189,45883643,45903488,45978675,46462881,4654065 2,47272185,47549519,47604752,47645995,47844464,47862686,47983283,48036324 ,48071985,48110751,48215610,48308457,48341005,48387427,48467450,48917016, 49042952,49222528,49325748,50935622,51017469,51054322,51086337,51137380,5 1174330,51246155,51299597,51319883,51427562,51580637,51635557,51931124,51 955737,51964705,52015111,52276898,52345760,52391592,52518993,52754871,527 87309,52939479,52955458,53021961,53039246,53104038,53189816,53361928,5345 3930,53458199,53476970,53517997,53569399,53590630,53621345,53723190,53771

202,54038536,54053788,54198206,54300245,54330717,54349366,54476147,554601 91,55532742,55803411,55937664,55979499,56011258,56053042,56077367,5615823 6,56196127,56237428,56287632,56320873,56490778,56517950,56606206,57580829 ,57643701,57677559,57714529,57741163,58251802,58313180,58339643,58392765, 58417348,58467375,58504160,58556598,58574925,58601866,58750637,60326947,6 0343060,60423407,60455797,60489941,60506744,60535093,61972244,62018791,62 853146,62898142,62950858,62973795,62996838,63020286,63049551,63069711,636 68754,63694121,63743891,63793155,63812269,63844453,64126081,64146390,6419 8563,64278166,64330964,64415575,64502595,64560089,64607328,64646624,64688 073,64737015,64770542,64789908,65200667,65249690,65301765,65341567,654606 91,65494438,65516055,65583499,67168024,67273910,67294143,67403315,6743644 6,67491264,67544234,67564281,67604702,68912755,68944792,68980738,69714617 ,69743627,69830980,69871685,69889880,70460238,70517191,71373738,71413324, 71439528,71454810,72061784,72120873,72238379,72309009,72416284,72438466,7 3919673,74074004,74107645,74170011,75675142,75686746,75699646,75717432,75 761077,77392005,77826732,77870324,77886499,78094779,78366894,78393621,785 48411,78642473,79354088,79374579,79380170,79504061,79521232,79541316,7957 4011,79577450,79608929,79650782,79676823,80054163,80115353,80133090,80174 338,80207928,80238627,81259137,81283728,81370944,81453818,81518295,815679 79,81796081,81829470,81870753,81890633,82756272,82863160,82887784,8295712 1,83014892,84279930,84296525,84384549,84419125,84527394,84640691,84752466 ,84813535,87000308,87208221,87211940,87326018,87370074,87460023,87548759, 87576481,87608062,88855885,88871260,88944894,88961409,88983827,89016499,8 9125840,89246897,89333557,89413835,89475135,89509723,89529680,89580696,89 779655,89807854,89842042,89950773,90013233,90045922,90117833,91102694,912 88130,91432361,91474382,91663930,91902838,91961203,92478130,92524193,9254 4692,92579675,92608029,92670857,92710039,92786742,93786714,93816400,93843 898,93863897,93896765,93954301,93995470,94614025,94688051,94711524,947993 63,94850443,94876282,94917402,95022160,95160537,95184309,95207183,9532820 7,95352756,95394535,95421315,95486751,95547223,95577297,95656508,95910930 ,95940864,95984156,96052746,96076587,96171796,96217531,96248530,96805998, 96867208,96882971,96942406,96965079,96985039,97052366,97135618,97168255,9 7245046,97262716,97410506,97434827,97492705,97867198,97906874,97969298,98 271226,98540146,98562260,98578860,98598452,98621723,98741424,100862989,10

0916183,101429724,101446276,101457021,101922436,101964376,101972838,1019 77598,101985781,102199395,102209045,102217181,102338678,102377028,102395 220,102462156,102579234,102740645,102763046,102783372,102828823,10285038 0,102887960,102955343,103171983,103231447,103526030,104605726,104679191,1 04846483,105080325,105189711,105259338,106029078,106060598,106091316,106 214306,106251529,107009801,107042850,107113504,107144758,107172324,10721 3171,108492712,108532862,108557527,108616600,108658838,109514347,1095663 88,109634341,109674281,109737063,110095897,110192484,111545087,111611837, 111638095,111659792,111682307,111704797,112886545,112951819,113193364,11 3663927,113752432,113789136,113815518,113834428,113874491,113922845,1139 74263,114337695,114394463,114412667,116907359,116988030,117030719,117653 503,117687125,117693094,117791156,117892516,117929099,117962929,11801332 2,118571089,118578942,118610623,118627449,118662302,119005483,119071352,1 19382227,119392815,119422913,119458234,119469188,119489098,119538890,119 562557,119624967,119647946,119680296,119692194,119732347,120288463,12032 4319,120358925,120365519,120376477,120404592,120424247,120425982,1204589 24,120491301,120498086,121172840,121177380,121200490,121212743,121217233, 143458436,143507432,143755797,144048591,144538748,144865627,144889465,14 4908589,144920927,144945033,144998180,144999676,145047396,145073859,1450 99495,145146031,145205541,145441620,145491909,145542281,145651409,145747 463,146667795,146693229,147016409,147044855,147096794,147130661,14713790 2,147235595,147240307,147379941,149040317,149114629,149771890,149938745,1 50055021,150104039,150130526,150270209,150316576,150387870,150466925,150 596411,150622620,150674053,150796816,150812954,150981620,151003600,15101 4134,151116279,151337788,151373200,151428605,151496718,151526841,1515507 61,151600441,151669555,151748425,151761865,151783736,151804907,151862296, 152007714,152275453,152328411,152552461,152750506,152856084,153277660,15 3315579,153431622,153886762,154832661,154959882,155008610,155257492,1562 75281,156340618,156394131,156498673,156785356,156836838,157490666,158192 745,158215299,158354780,158444447,158489945,159378594,159391863,15941097 5,159840541,160107588,160226971,160298390,160321180,160402539,160427778,1 60457127,160464911,160500865,161500364,161748056,161788348,161814020,161 848904,162010160,162083989,165255228,165283682,165505749,165542180,16557 2150,165608441,166271612,166306753,166319377,166342155,166367325,1663876

33,166390153,166403074,166551300,166598088,166674289,166773547,166903040, 169702278,169719429,169762807,169800062,169956450,170107782,170206902,17 0229218,170286749,170343289,171645589,171714521,171748145,171858076,1719 17875,171939290,172101666,172119582,172148538,172253585,172300124,172375 387,174476714,174519012,174592050,174633305,174714883,174775131,17480360 6,174868824,176966824,177089162,177326069,177416897,177583180,177600210,1 77652462,177724272,177769687,177839093,177867184,178142196,178180257,178 206628,178269664,178308911,178346771,178374117,178420220,178450304,17865 9933,178696750,178887563,179100045,179263332,179499839,179606157,1798300 12,180278683,180362527,180473153,180757628,180858459,181120126,181176704, 182631167,183188062,183211634,183246066,183376980,183570545,183623619,18 3654232,183694787,183711483,187334380,187384821,187467969,187522674,1876 28314,188828300,188909060,189152343,189221139,189501812,189543413,190800 133,190843209,190977609,191015089,191117598,192570150,192664972,19269094 3,192758083,192785957,192854674,192882100,193635400,193683743,193754519,1 93754806,193778000,193824544,194946012,194975941,195002837,195011645,195 022967,195040903,195042273,195082738,195108488,195135737,195298550,19538 6897,195438036,196731148,196844335,197557484,197587740,197614046,1977556 46,197977954,198026675,198215042,198252452,200071636,200089872,200132084, 200153210,200247702,200285297,200308474,200412089,200438701,200575256,20 0642485,200685057,200957032,201108930,201248200,201415592,201465839,2015 52769,201658449,201729910,201759349,202336314,202602197,202674197,202696 878,202739895,202778261,202826538,202847929,202904528,202906644,20292219 4,202982240,203030642,203087657,203188093,203209481,203299849,203328740,2 03371408,203508174,203651927,203680420,203881082,204071890,204792210,204 826114,205040726,205099959,205308347,205311261,205331874,205337514,20536 9075,205389460,205389878,205476189,205517610,205552864,205560119,2055692 47,205595753,205659491,205678126,205694363,205725346,205762139,205785485, 205841620,205857654,206589888,206610118,206633762,206664396,206915809,20 6952204,207526593,207573387,208447215,208497118,209007778,209197139,2092 21480,209241880,209265152,209317935,209342622,209363016,209414886,209604 734,209628819,209723311,209781828,209798068,209999790,210109286,21021735 5,210235308,210291309,211014671,211043895,211085683,211143054,211188102,2 11527481,211645082,211686020,211807505,211846415,211916142,212049349,212

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Cr2:12994,167739,227066,276942,454860,480776,574307,584523,788807,830765,86 9616,918533,1431590,3326203,3369049,3384196,3447827,4986720,5167107,59871 78,6056567,6081810,6200130,6216990,6388090,6606470,6657035,11123515,11150

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Cr3:66866,252344,325068,372448,409160,729510,979343,1007443,1048972,133197 5,1374976,1500532,1671466,1691434,2074515,2783715,2801981,2812572,3116438, 3232895,3673641,3971603,4223269,4272940,4432033,4467286,4536386,4562667,4 856087,5069843,5316622,5965594,6030755,6500083,6551066,6594461,6738287,68 01391,6863092,7152640,7179682,7229104,8812862,8822352,8853177,8934518,897 5742,8989152,9041094,9089178,9339759,9421187,10169819,10457572,11442503,1 1463730,11487506,11518755,11549596,11791277,11833473,11835243,12131687,12 539837,13295019,13875328,14010974,14143915,14168288,14476457,14520164,145 72596,14617925,14712042,14715887,14747000,14810290,14829166,14857093,1488 6796,14905426,15020349,15091248,15118733,15119804,15222262,15294134,15349 125,15509028,15932911,15965489,16093323,16185588,16285941,18384497,184002 03,18439595,18479770,18507382,18538587,18575971,19813302,23900401,2426398 2,25543168,25783711,26396178,27120082,27180143,27229286,27316919,27345381 ,27462460,30117400,30156873,30334755,30367264,30443869,30476636,30697330, 30848365,31535760,31606780,31705649,31741926,31774450,31981227,32016209,3 3161745,33185798,33432542,33458266,33514498,33534885,33600582,33660724,33 751018,33853747,34810784,34860208,36154647,38972592,38995532,39011226,393 40346,39357305,39463986,39555497,39604285,39640995,39705709,39734054,3980 3906,39832158,39924901,39987108,40096412,40247820,40404770,40726944,42179 870,42212734,42311742,42376356,42414904,42451412,42503482,42551595,425807 06,42684133,42752872,43263863,43281151,43700292,43795592,43884505,4404177

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5447,122529035,122566972,122738004,122792686,122822294,122838999,1228578 49,123524834,124284458,124345910,124483089,124772591,124826039,124979215, 125067174,125283184,125817204,125875313,126155325,127548479,127609937,12 9180589,129606827,129652185,129673392,129707351,129730719,129775801,1298 08755,129828454,131049511,131117193,131330902,131375324,131406519,131514 365,131559574,132223229,132255721,132492942,132510239,132570070,13268386 6,132736382,133084602,133172374,133189192,133340961,133537067,134508571,1 34589973,134625255,134661430,134698777,134892600,136781083,136808022,136 845647,136876849,136893356,137819499,137890750,138037429,138076206,13810 5054,138176934,139709617,139766782,139935751,140114298,140675313,1406957 90,140751864,140778763,141063953,141125705,143043702,143072873,143188053, 143244982,143314564,143388586,143431563,143602369,143670957,143698664,14 3736271,143757050,143803092,143836193,143848820,144078842,144098196,1441 01799,144240563,144269422,144497412,144520806,144538795,144569896,145504 527,145608291,145628903,145653627,145683128,145722272,145864179,14589329 1,145988445,146015386,146032307,146099485,147187590,147774712,147868063,1 47927668,148048835,148251516,148252757,148368341,148392710,149034081,149 054892,150508140,150601959,150643373,150760010,150867063,150899859,15120 7768,151818618,151862947,151878714,152653668,152672738,152679601,1527353 03,152775129,152796282,152805309,152831259,153178746,153487397,153688694, 153846481,153862719,153879467,153889601,153910995,153931342,153950471,15 3967013,153990749,153991100,154021063,154076157,154134232,154215107,1542 87700,154491076,154501571,154551639,155230888,155601378,156097836,156986 945,157005789,157585240,157633907,157657630,158126327,159184569,15937720 7,159448714,159500613,160685788,160710798,160767278,161059762,161081981,1 61087592,161139356,161170505,161213573,161320364,161396686,161416296,161 446446,162698133,162724877,162997216,164340363,164361707,164380864,16443 0644,165671506,165728468,165772299,166972974,167047721,167079380,1672750 87,167318873,167339911,167364471,168556901,168739827,169142103,169159380, 169185517,169212367,169226611,169281513,169316020,172153341,172186953,17 2292484,172314324,172357499,172448784,172626270,172770280,172979174,1730 02125,173029873,173058921,174023682,174058551,174680966,174874675,174909 418,175056030,175105816,175151789,177422783,177434128,177449803,17755374 2,177633633,178091742,178139482,178189976,178223739,178360740,180244097,1

80264743,180772475,180813165,180879878,180912675,180938727,180961383,180 995609,181053190,181098512,181122050,181176295,181221339,181248125,18147 5226,181504668,181633934,181649517,181737682,181877714,181944239,1819626 08,182019942,182043275,182121573,182124101,182150906,182179748,182183458, 182464883,182497683,183203034,183224103,183253444,183278844,183363538,18 3452014,183597998,183636273,183683938,183730116,184092481,184467570,1845 26208,184532028,184968088,185977310,185990417,186056554,186107980,186159 130,186174630,186200898,186236833,186273839,186293588,186306541,18631030 1,186395113,186396537,186428061,186438935,186699283,186713924,186734447,1 86748887,186801412,186822641,186906479,186937568,187020200,187045616,187 172954,187251280,187309934,187351077,187384786,187533092,188080163,18810 1739,188723077,188928248,188989795,189049191,189067066,189230204,1892501 28,189269997,189294159,189332748,189506531,189666680,189674483,189685881, 189728634,189746461,189767334,189874202,189875918,189894494,190030989,19 0070235,190090661,190093573,190182345,190200163,190214948,190243453,1902 78885,190312433,190354246,190667550,190789312,191074873,192758191,193015 642,193082557,193270477,193359205,193432412,193488071,193537559,19359267 7,193722330,193795801,194375013,194689413,194821939,194832855,194885959,1 94903701,194930028,194934634,194941433,195262872,195382307,195788147,195 807688,196504890,196576109,196656772,196767854,196798783,196837717,19683 8486,196961186,196963612,196980594,197001008,197019935,197063308,1972152 30,197480213,197522139,197575361,197639827,197672751,197737818,197766946, 197790192,197832937.

Cr4:29099,61981,102571,142550,200631,244361,367927,384533,408952,469347,763 229,942190,1045323,1113257,1161480,1222836,1274365,1334721,1732734,194732 4,2176026,2389800,2499117,2572279,2631009,2631895,2806909,2912140,2946481, 3036630,3066932,3116788,3142182,3174256,3536176,3699663,4346538,4659267,4 682768,4732750,4772796,4889866,4945172,5165055,5207139,5671477,5911983,60 86752,6447607,6671959,6773847,7007461,7746820,7778663,8107054,8222157,850 6340,9209010,9381818,9948829,9985596,10072255,10089865,10122649,10615417, 11372956,12089666,12125813,12186445,12246716,15123155,15206338,15348129,1 5552423,15725867,15732303,17520776,18512526,18573316,18627512,18647515,18 702355,18863913,18924948,18995419,19101216,21769481,21802323,21870453,229

38869,22995433,23018748,23274625,23311156,23703647,25082590,25143231,2517 3286,25200584,25250165,25268398,25295270,26425851,26441362,26486194,26580 072,26758118,27836263,27879272,27909413,28456089,28489008,28533928,290475 85,29091405,29124082,29139929,30508208,30533007,30577159,30611689,3068959 8,30762911,30811774,30872650,31071934,31095678,31154580,32407720,32434561 ,34461823,34489231,34541332,34602273,34700735,34848964,34871497,34910052, 34984841,35100007,35176401,35248847,35269594,35360452,36203250,36251380,3 6285777,36519732,36536225,36576067,39212879,40307533,40343424,40589717,40 864067,41201819,41203914,41400873,41660445,43000505,44446104,44995780,450 33142,46959282,46990395,47013138,47101105,47129258,47168972,47385771,4741 6819,47614900,47654509,47682174,47705578,47739193,47820959,47849766,47895 466,47937727,47983731,48035646,48067957,48114027,48138535,48176203,481957 00,52770125,52784678,52846029,52896651,52921454,52964094,53259081,5335120 5,53382829,53421172,53523832,53539692,53611701,53642124,53691035,53718375 ,53773371,53830757,53895208,53987764,54051213,54100965,54139334,54172210, 54218672,54235363,54376506,54637201,55542828,55593865,55610418,55656500,5 5684081,55775474,56027518,56068411,56180224,56274764,56326166,56430203,56 519722,56522570,56609540,56629407,56664054,56702299,56718312,56734161,567 80354,56980231,56995602,57014876,57092646,57267406,57339031,57372576,5739 7910,57441957,57457048,57506571,57556631,57576203,57596913,57614160,57690 713,57793751,58139397,58146234,58154685,58172459,58178960,58195063,582108 14,58249211,58264562,58290890,58296037,58413195,58553108,58743266,5876845 4,58835871,58914057,58929121,58933336,59000569,59026993,59071485,59632883 ,59666030,60002819,60062685,60118445,60204636,60263338,62295270,62309781, 62330872,62360062,62373180,62384375,62407327,62419426,64262262,64295154,6 6420825,66442069,66483593,68429049,68467653,68511502,68539771,68602903,68 665458,68747036,69176962,69214926,69338311,70489419,70506828,70600199,707 12161,71142577,73363929,76254746,76410420,76889348,76942300,77500947,7813 6933,78161506,80189105,80218062,80272792,80305179,80344129,80425343,82361 296,82445907,82493067,82616821,82680686,82716312,82716380,84059844,840920 69,84124240,84124440,84142634,84230619,84518558,86885907,86912850,8701923 8,87182436,87718790,87996623,88008782,88087440,88238448,88439367,89062189 ,90754153,93704900,93834946,94501546,94651669,94692346,95040022,95146135, 95206855,95211610,95436626,95441162,95588823,95732301,95912221,96076813,9

6099367,96360886,96467503,98489368,98927532,99029356,99187874,99240231,99 357999,99392101,99411783,99573350,99821464,99828327,99846115,99918661,999 44057,99976646,99993151,99993869,100006184,100006645,100045500,100056959, 100062430,100124716,100139595,100202414,100210847,100228466,100229017,10 0236762,100257907,100260274,100264620,100333556,100341861,100354257,1004 32841,100444178,100458721,100473723,100477462,100486651,100524679,100539 896,100738397,100755107,100774638,100810611,100827622,100829746,10086264 8,104553419,104595253,104656783,104679531,104725088,104763912,104905481,1 04947474,104968433,105031750,109880796,109901424,109922064,110028577,110 077762,114912239,114942909,114981272,117623903,117770644,117815990,11784 8472,117868882,117884876,117945256,117960646,118018861,118896969,1191790 95,121554459,121570638,121610489,121637960,121747970,123596522,123816707, 123845439,123898865,124017656,124100260,124397928,128803159,128842074,12 8947875,128986874,129086464,129198402,129760450,129792873,129815411,1299 83811,130016193,130033665,135535856,135594747,135622676,135651995,135679 163,138313173,138369786,138390066,138591243,138619836,138642592,13865828 4,139945108,139956970,139981027,140057416,140225440,140308984,140429555,1 40472281,140587125,140616983,140639055,140695059,141069147,141185602,141 247756,141298609,141310226,141346268,141449737,141466478,141485134,14148 8732,141787735,141957840,142278557,142331044,142352369,142653701,1426825 03,142777555,143346040,143593960,143733966,143839525,143885371,144635129, 144684790,144914361,145293039,145392979,145449746,145479880,145552729,14 5574844,146821410,147105438,147152340,147206465,147240069,147779721,1485 50590,148555860,148574703,148599631,148655276,148848283,148928719,148991 514,149001085,149210464,149358504,151005404,151080475,151126725,15206641 0,153425886,155402365,155432172,155492720,155792767,155825382,155848688,1 56550942,156618092,156669340,156737385,156787214,156805766,157512737,157 589751,160557053,160591060,161873925,161903944,162159361,162308134,16235 0342,162365413,162422830,162477082,162545702,163962148,163980821,1639997 55,164025528,164064190,164085425,164325423,164415792,164462787,164489699, 164668080,164765095,164790517,164813522,167205606,167235209,168788598,16 8804924,168883172,168921708,169019867,169085593,169101158,169173391,1692 37664,170154798,170186544,170229933,170345893,170635197,171889963,171948 042,172534290,172880610,176091232,176116034,176156361,176601113,17689902

5,176918741,176956797,177015194,177165002,178203533,178273030,178296647,1 78532041,178643884,178660759,179920127,179936956,180608623,180624051,180 639279,180668626,182199033,182393462,185087846,185119684,185142255,18516 0596,185175571,185356896,185436378,185489572,185636096,186522524,1865591 09,187390861,187586210,187701692,187717917,187751154,187779541,187825303, 187857192,188040020,188227951,188401975,188420909,188973194,189120984,18 9557313,189824882,189841021,189859009,189875591,189951863,189958158,1900 06281,190028108,190290460,190307263,190336803,190427510,190604047,190626 099,190690945,190711136,190862182,190903289.

Cr5:28949,81437,106819,155367,181463,207504,314518,339014,455696,742603,792 362,810636,946680,964250,988510,1013694,1054831,1094389,1124046,1156794,12 36291,1267356,1300025,1322087,1428111,1457317,1499175,1621184,1671278,176 3661,1850220,1944487,1959810,2474681,2491676,2523761,2930485,3076318,3107 861,3170878,4557280,4578107,4639570,5051784,5226842,5281408,5324373,54162 77,5480946,5585343,5740248,5857394,5876623,5916626,5979848,7001842,705437 2,7072724,7178103,7914554,13780601,13860020,13913171,13952047,13993495,14 210865,14387813,14413452,14450135,14483164,14534618,16224737,16245900,163 08247,16405957,16442795,16472881,16529556,16578422,16614242,16651045,1668 9462,16798640,16856100,16969440,17784226,17830992,17891044,17912219,17975 670,18035899,18092424,18133879,18277597,18323781,18377909,21257902,212951 37,21319693,21386097,21904526,22723454,22869771,22907824,22920932,2294074 1,22974392,23035295,23196434,23236207,23280539,23458289,23521958,23587658 ,24382182,24398596,24525859,24631334,25615591,27062023,27088529,27135699, 27258700,27324221,27416907,27584310,27617185,27652143,27875591,27906291,2 8732126,28786844,28829938,28857557,30787271,30831977,30857762,30886586,31 343574,31453849,31520709,32107084,32491730,32509774,32725531,32766822,328 10791,32937723,35315199,35477712,35793042,35810268,35857177,35901857,3593 3203,35965970,35987551,36064642,36141604,36629258,36656953,36705875,36739 499,36804365,39412798,39478776,39502211,39541408,39639421,39692332,398534 57,41600407,42569642,42917656,43348023,44338759,44387537,44478742,4451109 7,44787546,44823367,45249604,45477103,45553387,45638511,45676114,45766853 ,45831550,45857129,45888504,46097647,51554332,51605054,51642594,52234615, 52275103,52356701,52448212,52479728,54402403,55136432,55899739,55929388,5

5958617,57431053,58689866,58753267,58782840,60266666,60304171,60400217,62 069552,62349368,62402611,62456798,62903235,63004339,63069082,63114407,631 89582,65539847,65589994,65611873,65900819,65949060,67288272,67349096,6745 0499,67609408,67660640,67860025,68409803,68725130,70857393,70923358,71135 107,73219525,73340806,73933978,74107614,74289069,75493412,76784453,769287 57,77018388,77351559,77739154,77940652,78359271,81489088,81715365,8226043 4,82359674,82391341,82792625,83580303,83616403,83639762,83659833,84121068 ,84164538,85108200,85194347,85211913,85232203,85416393,85439039,85467970, 86176744,86194028,86293796,86311455,86331061,86378336,86399262,86464504,8 7434077,87487942,87525513,89286254,89318626,89334249,89375079,89396619,89 460396,89650677,89792508,89840934,89881551,90009941,90039078,92131648,921 77618,92218464,92269214,94269133,94473569,95116543,95199932,95272012,9531 0985,95400064,95628918,95659056,95726863,95751549,95856501,95897835,95945 319,95964055,96000795,96079027,96109244,96147777,96174186,96204899,962297 50,96417188,96440195,96488207,97067334,97125963,100100201,100127247,10022 6669,100243505,100433570,100557497,100611159,100787438,100830395,1021669 04,102895124,103013291,103292985,103309671,103381922,104436713,106585208, 106634782,106725331,106771209,106852966,106931806,106980183,107854230,10 8018395,109036234,109053335,109087037,109134291,109610053,109843757,1100 87158,110438357,110701527,111305878,111517294,112069946,112370311,112601 878,112916596,113085577,113972739,114043349,114103316,114108659,11414184 2,114265992,114293855,114567027,115223504,115353277,115480986,115879836,1 15940549,121320464,122169545,122257617,122297703,122501620,122524977,122 569516,122635531,122673622,122711641,127043842,127235153,127377031,12747 0813,127674204,128338984,128962064,129500954,131927748,131943615,1320859 77,132174296,132196383,132219304,134589943,134611275,134633657,134844589, 134912330,134974943,135059269,135212187,135296362,135313033,135354324,13 5392507,135487408,135570567,135687759,135789965,135959445,135999048,1360 64362,136114752,136140776,136180077,136201487,136221763,138394604,138454 192,138487253,138517235,138545458,141475178,141508488,142298353,14238822 5,142436152,142477096,142529381,142556593,142640901,142700856,142767160,1 42804687,142849609,142980766,143097138,143399676,143473699,143527974,143 643808,143670079,143700859,143758198,144342253,144379757,144415600,14447 0265,144491607,144541531,144585367,144661130,144697489,144744479,1447599

60,146253893,146339841,146398383,146415167,146457870,146600210,146630049, 146722479,146743222,147675836,147693826,147703361,147829441,147875751,14 7894948,148128331,148815759,149082878,149197815,149273254,149402113,1494 30915,149581731,149596379,149634268,149810923,149996589,150704724,150825 329,150924769,150943085,150999990,152096727,152137936,152721475,15293541 0,153412529,153798368,154969053,155694257,156156421,156191515,156250595,1 56283415,156536568,156809094,156934387,156936729,156937043,156955806,156 982059,157024032,157047715,158186302,159375408,159394869,159412615,15944 5829,159463556,161684570,162384064,162997771,165181241,165206198,1652252 55,165284983,165752915,166793586,166881177,166991270,167006676,167086901, 167131327,167170084,167174799,167276307,167925551,168943227,169078402,16 9153750,169218841,169243842,169327620,169364817,169518170,170209983,1716 56863,171912928,171969348,172017130,172035404,172205000,172222345,172245 572,172403528,172590025,172749522,173007591,173052331,173067686,17366318 9,174496838,174609731,174632624,174672156,174706084,174769272,174784676,1 74816335,174948557,174969133,175109645,175231947,175262638,175282310,175 774865,175936317,176067604,176096489,176177522,176219297,176263550,17628 4713,176482545,176493263,176539212,176567230,176598502,176636882,1770020 89,177705831,179369288,179398318,179440358,179476610,179663251,179698554, 179751111,179951574,179980302,180071163,180213878,180264448,180293505,18 0365313,180482795,180577677,180603691,180663700.

Cr6:205800,227752,252005,269735,303017,429457,531112,784680,827388,855877,9 11832,1134294,1154945,1174727,2344622,2625744,2781931,3015865,3348816,339 5546,4221686,6150763,6423694,6541883,6632399,6836121,7086072,7115116,7555 854,7801112,8043632,9989601,10058811,10403650,10567115,10627779,10723995, 10983568,11255358,11316111,11324111,11572817,11721301,12131467,12223689,1 2295461,12859556,13313777,13385108,13422966,13423292,13590185,13594666,14 128341,14129538,15624762,15650884,15669298,15713820,15746339,16539641,165 68173,16598133,16623694,16639979,18916565,19375199,19398138,19423005,2168 4936,21884440,21968899,22073654,24846263,24885379,24934664,24962428,25036 980,25066059,25733558,25792250,25821616,26033828,26112893,27298905,275345 28,27689502,27746590,27813694,27928445,27982152,28011652,28055495,2821323 9,28243042,28290714,30454076,30693633,30914751,31098832,31613739,32069806

,33020286,33023894,33389381,33404064,33408542,33413007,33416111,33416818, 33478496,33736490,33834387,33857525,34013250,34041418,34087636,34250202,3 4252352,34292986,34481092,34591207,34613630,37130282,37145523,37204540,37 501866,37549344,37634335,37699156,37799704,37888035,37911030,38602272,386 58883,38680402,39681702,39742387,39916614,39953931,40004040,40019311,4011 8298,40602450,40644699,41890835,41925290,41945550,41978274,41993861,42026 190,42167888,42190446,42235419,43295762,43327117,43355851,43386553,434055 25,43528441,43552097,43644800,43682990,43910164,43925526,43979409,4407422 9,44119145,44318072,44403900,44568765,44627544,44796596,44823127,44845514 ,44860667,45650154,45729389,46040887,46057309,46082810,46105419,46225754, 46228180,46259716,46304015,46826844,47695002,50348137,50406575,50479739,5 0564505,50744317,50808745,51448806,51813614,52122884,52138226,52839888,52 881818,52896371,52909609,52957090,52988956,53004835,53095563,53613433,536 58211,55538659,55628283,55930612,56016116,56075487,56100790,57282076,5735 0216,57473339,57525720,58014243,58298846,58332861,58404018,58465552,58542 355,58652437,58674430,63319877,63327975,63350106,63352863,63362485,633940 10,63709959,63755400,64642871,64677266,64731015,64763756,64797827,6483633 2,65241867,65292620,67002189,67122454,67562566,68649501,68810538,68894710 ,68920300,68951501,69075243,69913427,69932797,69954857,69994045,70144323, 70216262,70235763,72169372,72321961,72437420,72472449,72560565,72589696,7 2707881,72727044,73856921,74258195,75060947,77843106,77859890,77877447,77 914024,79020439,79071443,79098360,79154067,79231334,79268815,79289091,792 91942,81388499,81442039,81536714,81632422,82093974,82123865,82155864,8280 1519,82847936,83652997,83932070,84233831,84356242,84669284,84790544,84888 122,85178268,85260404,85288212,85374255,85417846,85442211,85466187,855341 01,85557927,85585389,85631995,85688966,85734752,87797904,87834989,8787438 9,87938363,87962572,87991925,88039868,88058575,88628864,88657347,88674171 ,88691312,88720739,89953183,89994977,90030081,90070795,93161185,93182761, 93252132,93366692,93476681,93520257,93618316,93643091,93688978,93758592,9 3823182,93843248,94660447,94676283,94720340,94739486,94767468,94869613,94 901399,94922112,98781880,98849613,98870602,99507658,99750162,99824405,999 26169,100429341,100592868,100936361,100968737,100987009,101020968,101065 792,101092265,101288160,101323061,101351896,101398354,101964914,10202940 9,103477530,103530152,103583379,103612659,103704599,103783258,104925175,1

04951875,105168358,105191814,105274546,105338796,105565429,105706581,105 952072,107003810,107019287,107059153,107178396,107178504,107197039,10751 9644,108170043,108200300,109263187,109527104,109574095,109816305,1098854 75,109976994,109997143,110023673,110039740,110106234,111250448,111288020, 113463061,113515814,113557311,113592268,113614992,113657311,114716486,11 4751611,114782400,114817483,114881318,114900110,114919559,116234968,1162 52551,116274730,116298479,118326206,118364263,118410266,118439794,118481 215,118498708,119774300,119876669,119933611,119990080,120056818,12010089 5,120121530,122480322,122498799,123695681,123740996,123786365,123843083,1 23873477,123910357,124016259,124037521,124214281,124236221,125116245,125 167716,125192629,126129256,126207186,126308553,126442383,126986996,12709 0469,127125330,127464754,129076520,129130271,129173746,129293743,1303461 05,130525375,130604227,130653745,131149902,131189517,132262314,132289157, 132316561,132998348,134570331,134730255,134786462,134831205,134911038,13 5089554,135210375,135299682,135543927,136011324,136054819,136131756,1368 91074,136947540,136969614,137612601,139563622,139624008,139802205,139857 691,140027475,140058844,140284677,141562759,141599463,141630096,14170942 2,141971907,142025756,142057468,142074315,142123546,143142313,143188746,1 43210234,143239870,144030149,144443301,144512377,144620145,145191775,145 551698,145582616,145669711,145703134,147836218,147870251,147898333,14914 5124,149601605,149783445,150419115,151125251,151197501,151228071,1512432 34,151639691,152057914,152090024,152140209,152159900,152291366,152322885, 152389362,152446487,152662520,153215558,153274321,153291865,153316775,15 3384664,153405328,153423571,153446191,153499921,153521354,154375092,1544 36236,155230594,155307236,155407983,155551221,155613732,155632844,155758 235,156126988,156161092,156223473,156394361,156415989,156504386,15652533 4,156552638,157321061,157336065,157368518,157744058,157768581,157970668,1 58018340,158087124,158194153,158286695,158349893,158367105,158388948,158 440141,158455488,158473387,158870547,158886991,159393101,159425707,15946 3964,159484776,159518664,159681390,159728693,159730544,159779440,1599233 34,159954098,160003558,160271392,160293151,160368209,160572866,161121390, 161187044,161248137,161538250,161571560,161628111,161657187,161681007,16 1870030,161919214,162293344,162344712,162418447,162440687,162516620,1625 71323,162661990,162752050,162775841,162804945,162825102,162844466,162880

494,164026762,164140691,165067294,165247866,165443820,165542686,16566379 2,165789306,165807502,166441028,166461499,166517538,166718436,166886496,1 66917340,167010782,167030620,167052048,167129002,167223262,168911301,168 955628,169033082,169104792,169134801,169168468,169267697,169290332,16940 5314,169421061,169435682,169474667,169853296,169899731,169992310,1701572 88,170588390,170620474,170657593,170676013,170782396,170842081,170858045, 170904958.

Cr7:43259,62643,85111,155066,1012103,1533788,1837636,1841891,1886333,19208 26,1921068,2032865,2065126,2227811,2252986,2519809,2606934,2739017,277243 1,2827276,2850878,2875026,2894434,2933195,2979033,3006221,3025151,3054314, 3071115,3091530,3117801,3437219,4011331,4658048,4698771,4726232,4743715,4 776547,4816574,4892027,5853557,5885326,7088289,7399404,7577175,7929851,80 05568,8183320,8243040,9161403,9218021,11610592,12306738,12441838,13835262 ,13857235,14013452,14212738,14587889,14608542,14666659,14705656,14756021, 15662321,18085022,18122596,18154506,18178410,18233458,18253060,18335683,1 9018009,19103905,19165264,19200132,21816411,21877962,22093379,22108531,22 131326,22169041,22250323,22702344,25618760,25655051,25699861,25728484,257 61835,25812068,25842636,25919798,25986573,28030486,28370567,28455313,2861 9038,28658522,28796256,29593125,29614491,29635105,29981780,30083021,30117 417,30179054,30280959,30428312,30503363,30540399,31491943,31533455,318915 98,31946837,31962380,32021588,32093651,32114906,32151370,32398147,3249316 9,32679502,33059407,33084992,33187796,33759569,33785578,33931825,33950201 ,33992983,34143118,34911343,34956424,35040453,35060312,35339492,35505204, 35521863,36140226,36173281,37063557,37125017,37169397,37227330,37256750,3 7347318,37386650,37435223,38067509,38095734,38130659,38208359,41193548,41 246700,41838649,41864241,41973344,42019870,42054047,42073962,42081102,425 33375,42577872,42614219,42642367,42714928,42791227,42867796,42894554,4294 8774,42968260,43026915,43162622,43201282,43210211,43227648,43265851,43336 907,43384505,43435783,43493657,43530080,44609852,44669698,44800176,448373 22,44906439,46199404,46519469,46553371,46574023,46590935,46667873,4672351 0,46804456,46994486,47014724,47141339,47210140,47451918,47495614,47846770 ,48022274,48058920,48076228,48092601,48117684,48265705,48429429,48481370, 48508819,48544211,48928297,48959625,48993663,49297925,49309611,49414950,4

9821411,49961246,50050077,50138799,50176409,50178216,50269672,50312167,50 618604,50725685,50767072,50855509,50871909,50963460,50984149,51016458,510 77711,51119353,51253943,51435267,51569418,51629362,51657940,51719272,5175 5663,51845731,51936695,51952912,52020304,52035335,52052863,52114795,52309 976,52316623,52382969,52426894,52473720,52528988,52584551,52611144,527076 09,52723335,52782466,52823317,52842990,53157261,53214671,53333318,5336531 7,53405036,53417302,53436568,53503144,53520457,53538304,53622957,53654357 ,53690391,53702725,53758476,53795785,53843394,53915850,53922431,54008615, 54137295,54157045,54177071,54216020,54403985,54418258,54471184,54497328,5 4551310,54558397,54621134,54660258,54702179,54751606,54796500,54857434,54 912828,55022238,55035100,55095197,55141476,55202598,55277964,55301203,553 49464,55494008,55618515,55668480,55705566,55848150,55891766,55956468,5604 9019,56187107,56224386,56596683,56671381,56700186,57363606,57435577,57488 596,57566930,57589980,57612544,57655358,57699151,57732222,57749918,578008 75,57820282,57878853,57914385,61815780,61846306,61888128,62076963,6210337 8,62190868,62377384,62380543,62413547,62429441,62439281,62533565,62577770 ,62645446,62671592,62678022,62706186,62836933,63156419,63273551,63339807, 63385883,63431014,63464342,63496664,63518993,63542779,63571516,63635126,6 3734787,63836658,63872340,64005228,64073026,64225506,64256482,64286239,64 323552,64417052,64768741,66786384,66786758,67141076,67163495,67859172,678 84287,67934228,67955951,68002819,69926089,69997575,70017184,70047583,7006 2735,70073764,70107873,70138345,70152637,70166762,70241298,70325955,70399 417,70642427,70707766,70778156,70960893,71096691,71154683,71198882,712472 51,71358914,71376375,71400759,71449469,71497708,71521799,71647996,7172687 4,71751116,71770703,71793386,71825161,71851586,72877166,73455384,75317281 ,76270287,76342579,76417575,76903217,76947092,77217474,77239456,77297541, 77303479,77365365,77417584,77545104,78093859,78121590,78170588,78219049,8 0842889,81422425,81500438,81601759,81754449,81771456,81964857,82820881,82 837717,82889177,82909782,83312959,83349707,83385765,83407838,84956802,849 99253,85014355,85121064,85420056,85491228,85512604,86977648,87004281,8702 9287,87497323,87603743,87633251,87698037,87715958,87741514,87796266,88540 145,88595238,88627970,88661182,88684280,88783122,88813289,88917152,889419 44,88958525,90523079,90539427,90592147,90812330,90851761,90904993,9154431 6,92645780,92648340,92873343,92900159,92965784,93066173,93122696,93225118

,93233270,93279482,93314127,93315106,93357691,93360031,94563289,94588970, 94630628,94679562,94891985,94955221,94992244,95060242,95078296,95191102,9 5263221,95298755,95318200,95436905,95455621,95543624,95719257,95756472,95 968489,96011048,96065153,96288964,96323925,96521942,96598826,96649356,967 37576,96859115,96969088,97099739,97199410,97285625,97949641,98792078,1009 95632,101001016,101009715,101699764,102358320,102464620,102770880,102992 221,103233209,103255144,103274567,103283013,103330684,103373051,10339140 9,103706400,103735755,104167099,104222268,104257737,104359226,105906370,1 05951509,107258367,107324113,107408870,107509412,107535236,107559911,108 017930,108070955,110071514,110096685,110126445,110129145,110149864,11023 6681,110318450,110391589,110424487,110441855,112823086,112848629,1129240 68,112948157,112969420,113326339,113353572,113640883,113707787,113757176, 113788156,114080435,114105453,114178653,114218582,114352394,114566269,11 4680186,114703853,114721177,114963829,114988956,115026740,115076372,1151 74007,115195992,115232006,115270621,115300183,115317805,115626289,115648 220,115811852,116003990,116044566,116067175,116217029,116319002,11634138 3,116478649,116547015,116716598,116781278,116883591,116954117,117200481,1 17274256,117305816,117337912,117442260,117460254,117497811,117640657,117 827631,118733415,119073398,122303321,122324387,122359692,122386967,12244 0239,122634843,122745653,122766270,122811327,122848616,122876418,1246592 24,124683042,124734218,124759848,124992215,125064358,126458354,126533117, 126595354,126671542,126696612,126781784,126866037,126943826,126995414,12 7073959,127114139,127139208,127833995,127863295,127896536,127956258,1279 65359,129265143,129556013,130002317,130100262,130117211,130366668,130417 814,130649606,130667121,131201814,132486996,132512535,134924788,13500686 9,135553732,135693594,135728243,135825524,135845461,135949778,136019524,1 36272383,136357434,136477714,136549033,136577349,136632003,136650607,136 838997,136893320,136954899,137366798,137383606,137414396,137431422,13745 3994,137493809,137521033,137567807,138264800,138397297,138740240,1389436 51,140076938,140244560,144279128,144328453,144889286,144946432,145003322, 145018517,146275420,146292805,146385209,146430441,146458079,146483410,14 6536229,146569874,146597313,146620375,146715861,146743131,146871913,1469 04131,146934096,147011388,147053771,147169275,147185337,148243464,149948 084,150137868,150176107,150271050,150412291,150511923,150739330,15086024

6,150919829,151423196,151452628,151477618,151506985,152902332,153147715,1 53607045,154656966,154806052,155212392,155230341,155278197,155577275,155 620122,155755826,155928606,155968611,155996594,156197332,156236883,15638 0932,156407224,156463980,156516951,156757619,156965297,157001161,1573576 71,158265190,158393107,158430907,158545156,158747514,158851804,158928569, 158966658,158983969,159007339,159046427,159055169,159072828,159105036.

Cr8:161222,263427,281424,348138,415401,458148,549908,660032,804885,1218533, 1268027,1359035,1408448,1426857,1490604,1614159,1633653,1679685,2055095,2 732044,3747899,3757091,3842999,3874384,3897678,5540656,5588901,5607156,56 66362,6749175,6782271,8148270,8476219,9062490,9100576,9175706,9205584,941 0495,9692541,9780861,9814486,9861916,9883132,11347660,11713158,12609117,1 2659206,13365378,14602827,14630927,14860953,16188798,16323545,16359222,16 388425,16416409,16444612,16534197,17954504,17964255,17987012,18099877,181 25297,18150293,18266774,18289671,18355089,18443369,19757300,19812620,1982 8679,19852045,20323527,20381967,20434567,20480271,20516522,20534957,20609 416,20707612,20871460,22507632,22555069,23210906,23298835,23396537,234501 67,23655784,23686374,23718328,23753451,23786381,24092942,24123239,2416440 3,24849522,27461095,27527995,27823832,28099429,28124555,28157200,29004182 ,29050079,29108379,29226940,29254901,30124685,30141920,30165168,30367601, 31903405,32613983,32633549,32700343,32765511,33303493,33592302,33615617,3 3665680,33693318,33713451,33863527,33941001,33975605,34146302,34866368,36 274953,36377899,36410427,36427107,36544713,36618088,36647519,36700905,367 16863,36762472,36882044,36958821,37000735,37551354,38319349,38447349,3866 8319,38840364,39573068,39678723,40037749,40085156,40111561,41683624,41716 363,41805249,41894717,41931966,42027264,42208797,42225183,42263157,424281 22,48281478,48344391,48710955,48737224,49289257,49307381,49341418,4935803 3,49382276,49412101,49427509,49484905,49563320,49895660,49960530,50023600 ,50052500,50093422,50379250,50402075,50445456,52218327,52254067,52326245, 52413558,52564548,52598769,52620150,52757093,53068163,53470313,53603859,5 4893121,59976810,59996443,60021779,60096342,60445244,60600118,60938950,60 957750,61003897,61029788,61090895,61620632,61679949,61770964,61807123,621 06911,62195360,63659635,63691194,63737308,63773093,64382112,64431251,6452 7399,64719311,64784507,66019046,66566490,66712108,66995147,67227072,67974

280,68201031,68657031,68821800,69142887,69150048,69389217,70976653,710050 97,71033469,71073672,71832012,71849895,71910655,71932086,71947187,7207002 4,72349490,72965973,72998638,73048372,73136960,73196418,73295585,75923235 ,76307739,77435207,77490525,77517422,77536510,77643468,77651637,77740781, 77756635,77786531,78330761,78906008,79285778,79586852,79713245,80096130,8 0266489,81312920,83317817,83779800,83808210,84219940,84279884,84325274,84 351219,84412991,84548554,84625566,84732202,85296965,86254062,86535486,868 78142,86956925,87077530,87149808,87163357,87459349,89158079,93507443,9437 0461,95789620,96266941,96301075,96392380,96415229,96481671,96705572,96763 232,96937768,96959458,97000663,97079072,97095890,97870282,98762701,995681 99,99905169,99945447,100521588,100819776,104323576,104358312,104382151,10 4521542,104581151,104717305,105256285,105431528,105547976,105594436,1056 63853,106421083,107397659,108064086,108083632,108116513,109685636,110895 169,110914474,110941659,110968544,110984072,111004997,111023423,11104787 8,111067399,111167038,111237710,111297957,111362541,111438792,111645187,1 11664368,112642674,112690532,112716380,112768322,112790283,112830632,112 899056,112960176,113643701,113721943,113749310,113770743,114323049,11433 8429,114353649,114372243,114397765,115890504,115948442,116120763,1161431 49,116166199,116231094,116247616,116267167,116271575,116299188,116853988, 116879432,116930921,116956810,117218624,117236393,117301701,117335399,11 7351973,117475597,117563532,117579970,117735592,117753791,118054014,1183 28115,118385218,118472329,118701450,119075100,119150458,119181046,119199 943,119227240,119428764,119696605,119755490,119872998,119921354,11994554 6,119952820,120884734,122175814,122200459,122244303,122268963,122314537,1 22367142,122421226,122442106,122467605,123375645,123728686,123772952,123 810167,123993063,124096227,124120097,124140634,126088512,126353584,12638 5095,126734459,128048974,129148754,129787426,129988219,130971985,1310050 11,131235188,131276836,131833036,131878480,132002770,133366597,133402654, 133782186,133798919,134580038,134826789,135293704,136748778,136772300,13 6803830,136836216,136874323,137810466,137814742,138239862,138455566,1385 05069,138881439,138883146,138915718,138950191,138975228,139725781,139764 396,139785792,139816905,139903723,139910597,140073693,140217584,14024465 7,140286104,140342891,140375282,140409588,140478586,140484717,140531786,1 40545742,140579392,140607542,140669274,140734056,142002897,142453003,142

609665,142980434,143042604,143270729,143390615,143567926,143786461,14390 5696,146068322,146069161,146099851,146128340,146195832,146233070,1462551

29.

Cr9:46431,242797,315185,346887,439102,582347,626876,641609,731332,864122,90 5584,983255,1037639,1058914,1124027,1231372,1261602,1325139,1402080,21774 92,2205924,2261944,2347968,2382247,2422654,2442052,3267584,3364535,347336 0,3671251,3701629,3749196,3792613,3893764,3927738,3946659,4176285,4573299, 4645935,5260039,5288707,5360293,5900426,6029644,6052609,6071061,6127330,6 222302,6257054,6327690,6358849,6455048,6624259,6638114,6672097,6963469,69 94399,7046901,7334464,7356144,7660299,7683175,7705368,7838621,7895438,791 5577,7931125,7978514,8127420,8231617,8253019,8290220,8313393,8345923,8416 196,8456020,8489006,8573166,8593619,8621368,8703733,8741389,8759490,90012 07,9039222,9072730,9089643,9109538,9133196,9238714,9295281,9316533,945900 9,9484236,9506817,9599213,9801153,9831068,9867271,9913373,9939880,1001414 3,10038041,10061829,10318849,10369368,10408395,10874781,10880887,10917810 ,10987774,11015952,11066050,11087447,11108586,11150966,11168364,11187028, 11213674,11236474,11308220,11331346,11355275,12031984,12071175,12187104,1 2212956,12272705,12301585,12347681,12503842,12588950,12654578,12666562,12 699776,12834688,12924111,13171577,13337242,13356342,13401548,13444553,135 45200,13681648,13701927,13771048,13832491,13899978,13972307,14044105,1406 7281,14237389,14286126,14352001,14379104,14422035,14472090,14550138,14649 846,14687867,14716849,14753463,14779526,14826616,15016475,15078990,151412 49,15282158,15335996,15353410,15394347,15426765,15486265,15501753,1557801 7,15636260,15732332,15755257,15769551,15808216,15900771,15919694,15974495 ,16066169,16083133,16102414,16200331,16257601,16289143,16320127,16347590, 16395204,16439783,16456242,16516026,16587758,16640702,16693969,16757041,1 6929803,16942642,17002171,17121228,17161527,17375677,17418788,17465228,17 487139,17627331,17690387,17760097,17782120,17870918,17907828,17948527,179 89790,18005255,18042702,18110746,18254023,18291898,18318754,18362105,1837 1966,18430742,18499087,18530100,18651931,18680679,18717903,18862658,18878 842,18903750,18936179,19022470,19052562,19116543,19151703,19176273,192785 26,19296871,19345647,19414902,19434980,19530883,19582630,19634699,1964973 8,19736356,19754476,19798344,19825627,19876496,19917291,19982455,20115657

,20138514,20180680,20209017,20270743,20308166,20355885,20481818,20553571, 20601177,20648805,20670966,20737847,20758306,20801991,20873922,20882525,2 0908513,20945207,20971343,21011287,21045062,21174141,21214877,21258474,21 281544,21316649,21338145,21362014,21391231,21435859,21510160,21551566,215 92004,21606656,21652666,21733644,21806564,21855096,21890326,21923279,2194 4818,21978443,21981583,21986218,21988896,21991752,21991923,22018781,22023 795,22030438,22056499,22082380,22103813,22283153,22529329,22622698,227402 32,22856899,22947998,23123107,23161189,23182584,23197592,23226243,2334164 4,23361805,23380965,23513235,23552388,23571926,23612260,23859980,23912009 ,23938481,23971815,24020817,24048247,24131844,24161849,24215545,24260531, 24289551,24332192,24399969,24477128,24514390,24713105,24732482,24786754,2 4836170,24911674,25028231,25242181,25302474,25334073,25349769,25352201,25 384487,25486469,25631130,25677257,25719953,25743020,25749735,25809071,258 30763,25864831,25902763,25934932,25953799,26211082,26235839,26273322,2629 6370,26326539,26382217,26419301,26444299,26555763,26581766,26647389,26690 350,26710092,26773231,26955661,27067529,27168315,27201459,27436033,275829 31,27601570,27664162,27704877,27722059,27839691,27915216,27980241,2798331 4,28025818,28055603,28144832,28152658,28303495,28323673,28339748,28379412 ,28399778,28500104,28560130,28587774,28652515,28683511,28753170,28775262, 28817957,28851011,28875332,29112844,29162253,29180721,29198885,29244165,2 9295756,29411568,29473445,29509448,29524697,29574626,29834371,29887375,29 928566,29961076,30019155,30040145,30115718,30146063,30222869,30326115,303 81063,30398367,30435441,30451024,30497203,30531968,30552008,30580708,3069 6182,30748943,30768128,30846226,30868163,30899622,30967379,31024265,31051 186,31077301,31098614,31149228,31234959,31312460,31359923,31470280,316150 43,31655727,31822262,31872062,31894764,31912729,31970533,32005635,3206837 8,32246514,32301073,32316967,32344825,32537141,32564749,32590578,32618915 ,32670725,32690443,32737092,32873872,32895426,32938186,32976520,33029015, 33132518,33222318,33309913,33514843,33608615,33634591,33659570,33703234,3 3718793,33751720,33782141,33804167,33852474,34026538,34107232,34124312,34 210872,34365357,34467119,34504634,34537277,34718166,34771534,34823809,348 68377,35039598,35061503,35234309,35244061,35300109,35329331,35394747,3553 9444,35599966,35615896,35641859,35696802,35858543,35894737,36034570,36060 451,36116440,36323752,36351074,36372416,36437700,36448070,36499448,365304

04,36576342,36697735,36718368,36739451,36856268,36867495,36936389,3700898 4,37010448,37033361,37034617,37364675,37390630,37432264,37490577,37621667 ,38298804,38459763,38503875,38528531,38567913,38599297,38626309,38733080, 38994130,39104547,39213995,40560848,41480523,42373963,43315546,43437359,4 3445985,43518651,44466205,44768659,44785108,44804679,44827045,44864688,44 900526,45088879,45435888,65596318,66457322,66837485,67333677,68176152,682 98352,68320859,69452041,69827539,71000301,71015733,71045958,71072760,7111 3835,71210894,71243824,71281701,71304246,71364351,71372114,71421359,71458 420,71489662,71558545,71607398,71612379,71633113,71693777,71806130,718343 80,71888362,71974700,72067786,72100569,72134376,72196579,72286253,7231312 4,72338610,72417239,72442540,72738339,73090916,73416273,73597458,73636237 ,73691918,73706951,73742312,73798690,73844875,73900251,74049608,74066260, 74153929,75316142,75771314,76162902,76184785,76227478,76248227,76376222,7 6615662,78155352,78322176,78340884,78536862,78571504,78651491,79506554,79 605586,79698931,79776237,79829575,79869852,79980974,79998112,80196611,808 29568,80932789,81117824,81163473,81241721,81295919,81371636,81673370,8177 7861,81819044,81924713,81944626,82020541,82074708,82275591,82729822,82750 359,82931247,82977316,83119757,83142033,83166656,83210614,83253807,835535 17,83580505,83651505,83718911,83786452,83874778,83998047,85451828,8560179 6,85627408,85715943,85799271,85883879,87445656,87533427,87560461,87616257 ,87678382,87782211,87915557,87983311,88003668,88093033,88128438,88540410, 88837481,89252706,89311754,89337524,89374205,89402721,89519033,89573470,9 0390559,90813464,91036902,91076863,91261952,91535461,92216384,92723877,92 779249,92814783,92898806,93059277,93111241,93139004,93148187,93181424,932 11947,93240694,93299691,93303146,93344537,93418243,93436884,93464770,9349 6948,93520363,93529779,93557698,93587682,93628105,93659034,93697190,93752 143,94342486,94646318,95140218,95248571,95347484,95487407,95588200,959533 41,96085370,96541517,96578495,96609363,96648085,97630451,97714914,9774127 4,97855643,98010529,98256309,98558855,98640671,98685797,98724671,98748034 ,98775459,98884945,98937662,98956488,99247012,99322245,99815929,100059075 ,100089171,100422326,100528320,100537763,100620730,100636240,100664194,10 0868900,100931899,101815339,102064139,102127680,102222771,103432451,1046 03846,104649651,104675628,104677951,104728250,104965863,104974365,104989 486,105055257,105110755,106675148,106759839,106776192,106861191,10689680

9,106944031,107024516,107040713,107076147,107476188,107549593,107580657,1 07651232,107680639,107801093,107975595,108181778,108620961,108643176,108 681246,108777642,108834044,108848288,108917072,109190126,109233625,11010 1440,110131397,110511053,110535984,110606016,110687961,110709587,1107292 37,110752789,110783036,110850146,110872307,110911118,110929785,110974998, 111037829,111145453,111172451,111203318,111256032,111309301,111365050,11 1429924,111626090,111655932,111688767,111714038,111766659,111776224,1118 09530,111864802,111880693,112025473,112042039,112153156,112282070,112388 459,112511426,112572791,112824301,112852335,113779436,113794500,11413363 2,114154827,114184108,114287275,114332765,114342146,114348193,114374729,1 14438945,114505919,114542761,114567760,114688103,114707908,114844799,116 720998,116742833,116807848,117032340,117032448,117101725,117112633,11720 5332,117214592,117231191,117242845,117278844,118332524,118506991,1185918 70,118731773,119033334,119057131,119105667,119186027,119289274,119345083, 119346694,119401227,119402951,119544212,120234269,120286838,120374480,12 0401869,120444525,120462253,120565315,120637262,120682548,120737051,1207 66554,120789229,120813098,120852000,120891637,120913104,120933677,120978 387,121010987,121068327,121291744,121416241,121467481,121500340,12200100 0,122033554,122073899,122574569,122642456,122932339,123293510,123313246,1 23676396,123742818,123858430,123944635,125328476,125367694,125436147,125 506352,125517348,125566096,125696946,125764108,125789160,125789907,12582 4055,125868610,126249761,126303371,126394539,126423340,126453684,1264794 71,126497262,126520497,126590959,126618581,126951284,126984182,127125029, 127140634,127317473,129037386,129056597,129072443,129141054,129157541,12 9909750,130822871,130843282,130870258,130898480,130971018,130997892,1320 85965,132270020,132319215,132394270,132785906,132899394,132926691,133003 158,133553287,133572684,133668039,133955154,133985840,133987861,13400390 0,134335407,134458378,134513578,134889005,134912614,135082979,135110884,1 35138258,135151461,135156270,135205006,135420847,135470176,135564734,135 786904,135796608,135822290,135838089,135902962,135954310,136326857,13652 9766,136566959,136618314,137828650,137903343,138074968,138093775,1381257 63,138131005,138197209,138219743,138275622,138539219,138602228,138718813, 139376599,139736198,140638607,140689373,140755119,140935622,140952916,14 1001866,141054761,141087366.

Cr10:104427,135656,224961,240788,315525,437940,467318,484159,618409,747115, 762872,803721,824693,894838,910983,1075777,1116294,1155767,1282828,131454 8,1469237,1507705,1588114,1648439,1665029,1902367,2537042,2589776,2729830, 2757337,2944715,3310298,3378262,3444489,3492888,3536211,3590948,3658434,3 699729,3733731,3785605,3802761,3823636,3947069,4884322,5465671,5852230,67 75928,7297757,7805481,7851414,7866557,7935761,7955720,8003333,8053776,807 4437,8209817,8298964,8377252,8498892,8561880,8579463,9399010,9807832,9931 024,9963634,9980705,10077215,10136339,10175411,10249897,10268682,10273752 ,10673076,10707944,10754532,10904090,10936611,10960923,11076046,11133823, 12549961,12590175,12702818,12743642,12802455,12924440,12969666,12985325,1 3004213,13089766,13145649,13169066,13962897,16175957,16257742,16281080,16 299970,16318694,17224358,17372524,17640913,17683974,17733927,18309005,185 79862,18617051,18629603,18647504,18652290,18670017,18697682,19534443,1971 6489,19788266,19811754,20206652,20225654,20243642,20267492,20298442,20698 518,20717789,20912974,20955050,20973723,21020221,21097769,22037809,220923 10,22147332,22900143,22926034,22986018,23044757,23102588,23128475,2318147 1,23204803,23665438,23701100,23846857,24034646,24165775,24187867,24193273 ,24542427,24595720,24633773,24688985,24720825,24789485,25137772,25251124, 25270441,25396749,25508037,25556034,25650034,25668632,25702280,25717911,2 5753080,25791570,25836449,25873385,26398386,26424996,26463130,26557610,26 643533,26695288,27014467,27047640,27132992,27466165,27534596,27549961,276 33772,27667087,29399839,29424176,29446722,29481569,29603620,29616766,2971 0788,29763659,30377448,30740379,31742176,31772454,31796855,31985404,32085 338,32161486,32281199,32309005,32492092,36186557,36236775,36283010,363107 50,36342038,36403422,36605398,36644263,36666512,36700944,36871896,3691086 4,37047826,37068075,37088576,37143261,37214613,37304120,37722354,37840199 ,37908262,42433540,42469894,42502346,42523461,42636467,42682133,42835341, 42897610,42952225,43012693,43039187,43086992,43143078,43172941,43201033,4 3224701,43253587,43271778,43280580,43291861,43434154,43460874,43531949,43 532031,43769444,44008335,44068558,44180511,44194617,44454186,44627467,446 55275,45820136,46148326,47080907,47619848,48367621,48421175,48423374,5010 0889,50147024,50179201,50183502,50224766,50240165,50293456,50306386,50435 876,50750917,50768232,50793321,50824619,50870071,50895334,50932371,509509

76,51015644,51110279,51525699,51563993,51586514,51785326,52007988,5326145 1,53333524,53392384,53470001,53547402,53573969,53634419,53686204,53711220 ,57003629,57061057,57095400,57113620,57213026,57264740,57292460,57315135, 57345779,58417350,58434359,58461075,58510079,58538600,59378572,59434527,5 9484738,59565128,59731111,62424459,62495842,62519029,62548674,62577107,62 604856,62634621,64306881,64321478,64379326,64494790,64580575,64603279,646 31605,64671276,64702183,64725175,64759410,64859984,64916469,65218797,6526 4126,65402586,65437155,65562475,65593561,65625589,65651104,67679146,67721 480,67794995,67821123,67964463,67999246,68054025,68085325,68128645,685756 38,68598292,68613351,69005799,69051544,69141544,69281294,69302485,6953067 8,69664881,69724433,69772560,69805786,69880519,71212333,71343400,71351011 ,71373767,71393025,71632466,71828837,71870114,71985733,72207860,72350779, 72567044,72593611,76716281,77052632,77622586,77645229,77845917,78198749,7 8218575,78265129,78449312,78533060,78552782,78569223,78586317,78615458,79 840993,80097033,80130592,80217168,80235368,80281736,80348121,80410110,804 87312,80586918,80870324,80883083,80919442,81163159,81443896,81682470,8203 3008,82082340,82125104,82227630,82301802,82518789,83507636,83542467,83589 134,83853792,83871324,83918548,84509461,85775232,85802933,85845488,858703 25,85912606,85977175,87189235,87209524,87251999,87290114,87373863,8749441 7,87517613,87543396,87672793,87715154,87779870,87898003,87991916,88069416 ,88145546,88242825,88306141,88595559,89262987,89318334,89327658,89363781, 89368910,89431060,89440001,89519376,89603424,89674157,89682833,89700671,8 9719447,89726745,90008047,90014221,90047709,90072352,90131045,90211653,90 334179,90373845,90416756,90457633,90459352,90487339,90497588,90524543,905 44073,90599996,90620192,90880457,90904076,90966393,90983629,91000601,9103 0016,91450380,91501477,91539579,91585078,91617124,91677407,91814165,91824 299,91855665,91860600,92299184,92766878,92791166,92821721,92862763,929847 83,93127873,93604600,93730058,93867230,94098321,95196853,95262497,9532742 9,95439373,95606355,95634154,95806981,95859929,95985995,96010981,96061793 ,96093632,96117560,96464730,96650328,96684436,96708226,96769769,97021389, 97066807,97110879,97112861,97144833,97168140,97232205,97250630,97296254,9 7792923,97893426,97923821,97953286,98981914,99115709,99191935,99558310,99 600367,99734191,99825756,99868267,99898133,99931546,99958168,100036209,10 0176869,100225657,100250186,100278623,100330535,100383999,100406283,1004

23861,100480890,100533143,100572781,100592316,100759697,100778221,100804 071,100858626,100976829,101049048,101934936,102088001,102259568,10256659 1,102639518,102691412,103050571,103249036,103284070,104752960,104776391,1 04905604,105500857,105662633,105729887,105760075,105859279,105875326,105 941240,105966362,106028070,106071001,106152899,106234646,106311310,10642 3746,106473048,106521003,106623425,111713930,111750764,111834579,1124313 20,112490002,112511155,113414787,113472173,113495569,113519938,113565450, 113593116,113623742,113668388,113697068,115107210,117702645,117767890,11 7830114,117935335,118047582,119108811,119262900,119949748,121287250,1213 07428,121362660,121719580,122128358,122244308,122644992,122871745,123098 249,124503149,124884868,124912115,124965296,125979434,126003257,12615791 0,127060486,127136511,127155823,127263351,127296145,127419237,127495807,1 27706028,129566093,129663158,129773196,129921652,130113916,130347000,130 383831,130466291,130546521,130566523,130689796,130706844,130802451,13083 3721,130900206,131293025,131342129,131397821,131620714,131679393,1317044 34,132171541,132194172,132253874,132488870,132674609,132736937,132839043, 132982455,133006115,133098703,133231622,133298189,133347957,133598112,13 3658347,133942779,134199587,134441569,135275358,135322976,135328360,1353 39845,135371105.

Cr11:198510,283928,366710,440343,812188,1386069,1653505,1982318,2637318,27 73371,2789062,2807522,2896783,2980831,3158634,3197290,3403060,3678446,370 6446,3768301,3815536,3840691,3865786,3908522,3989226,4081504,4923182,5060 791,6272677,6273744,6428106,6464912,6721560,6761413,7329474,7489819,78759 84,7895876,8200216,8262401,8779172,8798853,8939887,9034960,9133745,941641 4,9462534,9589840,9615083,9648324,9666472,9745836,9802952,10203610,102441 05,10302016,10331664,10346994,10537721,10628786,10646522,10670992,1070848 9,11068686,11211122,11272817,11317490,11399692,11486502,11543021,11663893 ,12087993,12149531,12721053,12919909,12962397,13146238,13172227,13276311, 13475725,13509617,13573554,14104256,14138673,14313329,14486039,14969562,1 5003073,15063638,15098718,15816567,15899824,15936479,15989350,16008235,16 047917,16117179,16224375,16254820,16296412,16302939,16983977,17179440,175 43203,17593115,18392983,18591571,19198018,19351515,19855544,19960024,1998 5372,20490704,20557535,21460878,21540432,21605151,21639207,21653988,21657

218,21698550,21726703,21795849,21854771,22025121,22081211,23118296,232941 83,23447962,23524897,23598742,23628562,23679716,23699667,25101510,2513577 5,25158340,25199969,26001261,26573752,26762635,26849848,26876180,26970603 ,27025520,27152921,27224249,27270978,27295878,27323139,27385939,29166202, 29501022,29730932,29776537,29800878,29964840,30453413,30479945,30496760,3 0566372,30653670,30741502,31362651,31840416,31901999,33697591,34503469,34 666850,34684543,34702158,34777725,34862655,34910077,34916710,34918375,349 40737,34971368,35036398,37949787,37983342,38025396,38060818,38826255,3890 6438,38955541,39144078,39182880,39406233,39439184,39734682,40695479,40946 450,40965828,41059281,41096261,41119492,41257018,41260962,41343906,414236 19,41449038,41472394,41532609,41554480,41605715,41636673,41687702,4172027 1,41781591,41808035,41824482,41843324,41874054,41908482,41919836,42202424 ,42279825,42378027,42461917,43390132,43406806,43451457,43551540,43928297, 44084849,44158153,44302154,44381044,44396024,44519978,44737646,45042443,4 5105041,45208835,45313545,45447995,45486373,45517386,45527856,45600806,45 620673,45701802,45707560,45878876,45894636,45931019,46027176,46073113,462 02305,46744925,46806553,46849360,49038852,50182364,50218185,50250131,5027 8170,50297005,50344991,50440270,50474459,50490256,50629395,51205141,51228 126,51293595,51401453,51428310,51446822,51462934,51489207,51518519,515267 55,51563131,55710184,55759573,55787658,55839633,55891082,55920262,5596631 6,56021284,56058690,56311090,56616915,56669830,56702462,56771412,56865255 ,56905911,56952632,57577096,57918692,57951574,58111700,58202974,58286886, 58318056,58687627,58704232,59129579,59156405,59184192,59205263,59220879,5 9623433,59852078,59884241,59893606,59920231,59951433,59976502,60049173,60 110542,60858487,60942716,61727791,62838511,62914709,63067138,63212720,633 67058,64151812,64188789,64333296,64544135,64700976,64832496,64885445,6504 5615,65249089,65371604,65533000,65674153,65705108,65928342,66066993,67961 959,68088831,68113724,68144283,68474169,68540316,68958660,69012138,693322 60,69350646,69351721,69566488,69569224,69806270,69834983,69851304,7014907 4,70552397,71236763,71279222,71492618,71523318,71750917,71796929,72023828 ,72090536,72115610,72184290,72215952,72227849,72248366,72268801,72291927, 72332931,72390640,72451380,72720199,73023353,73768225,73885140,73994285,7 4057931,74153008,74257489,74330208,74496037,74689372,74744502,74763783,74 781124,75028785,75085790,75147661,75996547,76660780,76684046,76731050,775

55356,77592909,77620340,77670263,77697251,77727129,77811196,77856177,7816 4984,78205974,78251485,78275931,78279790,78374914,78791341,79949070,80399 615,80425472,80462334,80558166,80788640,80865359,81179117,84176261,842471 23,84353294,84493679,84558671,84576644,87460664,87519529,87913325,8795122 1,88105220,88147213,88283890,88338165,88957047,90882169,92708710,95726855 ,95762965,95795807,95817904,95847064,98221812,98406907,98423911,98582997, 98677844,99097199,99097699,99187652,100813264,100857442,100890819,100994 866,102196550,102393055,102572794,102707339,102822733,102877651,10478896 2,104937459,105395532,105641981,105660692,105686636,105719522,105758104,1 05834124,105878844,105950806,108914383,108937676,108964399,108986095,109 035215,109620874,110177824,110666608,110696964,110697305,110721187,11074 8070,110776537,110836077,110855294,110871107,110894702,110917563,1109431 36,111977919,112142799,112163817,112208482,112480094,113075938,113919675, 113939539,113978028,114008823,114107966,114410662,114664651,114704292,11 4720633,115937231,115982197,116045865,116055191,116092778,116116828,1161 60176,116176971,116224775,116233398,116250285,116269448,118576463,118852 137,118920453,119005088,119229964,119256775,119488812,119696100,11979006 8,119853069,119893752,120733435,120791311,120815567,120850185,121122197,1 21481407,121502745,121565897,121691425,121789249,121942321,121993580,122 051699,122108709,122188447,122230221,122235623,122267336,122289272,12231 7996,122367644,122394829,125806101,125836330,125969698,126030615,1260741 92,126100932,126489863,126596817,126630431,126648140,126754451,126809014, 126852438,126892213,127018573,127170773,127262822,127329093,127396651,12 7484644,127730607,127775080,127838942,127890990,127941828,128020368,1280 57483,128079701,128126292,128148128,128187902,128597015,129290180,130156 997,130173995,130870215,130928308,131018917,131046160,131085110,13109979 8,131461896,131499381,131520368,131677667,131727426,131841267,131916978,1 32824474,133026354,133044380,133069420,133091458,133120937,133439342,133 477595,133521666,133561399,133696584,133795017,133931013,133981405,13399 7052,134136920,134159467,134438991,134496459,134555214,134577633,1346182 53,134638254,134668665,134824671,134861391,134888574,134921483.

Cr12:161382,223422,225655,257060,261784,325433,628090,633417,791210,100201 9,1163896,1286177,1354345,1382293,1399443,1525353,1543590,1698010,1765933,

1862158,1878154,1948947,2087045,2115710,2133967,2172291,2487001,2535417,3 021182,3050936,3077219,3099291,3364800,3438710,3461462,3531775,4070332,40 97468,4119409,4164716,4365949,4416085,4521900,4543487,4644782,4672394,469 9232,4852662,4869928,4924301,4947598,5044426,5065107,5105597,5142865,6488 450,6605105,7865803,7918460,8268997,8311376,8368213,8804572,8841741,88489 29,8896714,9064374,9095226,9160234,9250601,9286801,9321267,9408619,986208 2,9914889,9967813,9991096,10356914,10402627,10857611,10876337,10909412,11 003454,11043932,11074915,11120139,11164751,11380187,11828062,12058411,120 78816,12106783,12532984,12827764,13040944,13514069,13631960,13711376,1372 6492,13804375,13832945,17182120,17206210,17339078,17486045,17743848,18748 350,19733745,19859178,20009962,20238866,20563643,21000586,21292056,212967 07,21329424,21368797,21472254,21587314,21627525,21712545,22438082,2264548 7,22684090,22700388,22817625,22868165,22945808,22971779,23024430,23330149 ,23404163,23423470,23440634,23485126,24237747,24254842,24273423,24295482, 24313569,24381902,24400957,24417553,24436868,24471760,24779491,24861033,2 4920666,24935692,25101572,25154495,25275497,25401701,25471480,25622352,25 821922,25971898,25992543,26035842,26085053,26245910,26358930,26422648,272 60414,27433752,27495857,27511513,27578912,27620727,28173195,28531994,2859 5296,28650565,28687331,28711783,28734570,28768139,29003597,29597846,29650 232,29654944,29691138,29820400,29859352,30170229,30235421,30295781,303411 90,30391184,31579078,32020369,32218288,32769632,32930378,33195214,3321403 7,33252082,38205610,38301897,38363338,38373794,38410687,38424982,38442948 ,38482543,38502841,38544100,38544863,38560070,38616965,38692547,38881918, 38989405,39017083,39122853,39187660,39432943,39510383,39536022,39595245,4 0016168,40236374,40274325,40321846,40350374,40380763,40380789,40405868,40 433169,40454645,40460527,40550073,40586631,40709957,40725571,40825715,408 41832,40857620,40872856,40892329,40893988,40912212,41755156,42362561,4239 4365,42762714,42824944,42874403,42934089,43006387,43055117,43071393,43096 024,43563127,43597913,43628705,43650836,43769228,43794431,43918532,440337 69,44262606,44285480,44316485,44376031,44511487,44641138,44715810,4478423 1,44852066,44981990,45001363,45057396,45894373,45959370,47234813,47282531 ,47356272,47494129,47523745,47548076,47636185,47737447,48110551,48263828, 48426295,48474853,48687362,48721832,48763234,48848640,48917007,48962131,4 9012916,49048738,49070469,49149597,49248614,49255798,49328962,49356534,49

750588,49892151,50078124,50156640,50363014,50514478,50537060,50592492,506 46754,50665946,50733938,50744171,50763415,50796319,50797431,51161969,5117 1224,51181699,51182412,51185950,51203953,51204938,51207704,51207733,51208 122,51213433,51214327,51218114,51218323,51219701,51231061,51232590,512326 15,51233408,51236802,51237816,51239247,51242403,51243077,51243411,5124358 0,51244702,51250037,51253683,51254774,51256065,51272984,51278067,51281977 ,51282518,51301431,51301627,51304259,51312472,51313531,51314760,51319346, 51320290,51320334,51321994,51326702,51331164,51337669,51338350,51343660,5 1349426,51350285,51353830,51365312,51448918,51504799,51584147,52047306,52 062088,52078101,52078924,52095370,52176235,52216897,52612993,52674709,526 91103,52719253,52751660,52822258,53347273,55126225,55355233,55399467,5544 3874,55448392,55508087,55520676,55562613,55583243,55616089,55647750,55677 756,55696789,55721803,55837986,56015768,56048203,56404566,56749494,569846 06,57125879,57306412,57313770,57329260,57534470,57891804,57905687,5794517 8,58018979,58115271,58133256,58156510,58202419,58256010,58386125,58402479 ,58417789,58459066,58476065,58498414,58520735,58537716,58584148,58597570, 58776258,58843966,58872839,58911415,58970816,58997192,59079775,59117994,5 9120377,59152365,59196859,59275720,59301570,59411981,59455437,59469315,59 495114,59507893,59542155,59560439,59578868,59659532,59677228,59773458,598 00581,59843473,59893825,59913846,59950966,59974930,60073240,60240700,6038 3069,60401689,60469422,60503434,60559070,60644877,60880558,61037727,61088 474,61315588,61353702,61821052,61899005,61994195,62038300,62135592,621907 88,62211858,62238511,62275812,62334359,62392548,62408708,62411401,6243890 5,62442788,62470897,62471458,62617630,62658228,62707586,62757863,62782467 ,62826100,63158712,63238592,63266211,63304447,63314504,63379516,63418786, 63445092,63515014,63535191,63644334,63666496,63714496,63777954,63816174,6 3894818,64732294,64830566,64874102,64918752,65296837,65322994,65345345,65 376522,65576219,65675628,65703184,65730190,65768375,65783378,66342868,667 63167,66863126,66895088,66943690,66993205,67069003,67077836,67089330,6710 1940,67106233,67224990,67247949,67284509,67362612,67390923,67428740,67628 049,67845462,67894648,67904658,67920566,67983377,68356383,68371541,686540 84,68698086,68716067,69279736,69284268,69305458,69339043,69407331,6960246 8,69669446,69727190,69851374,69876959,69925695,69962044,69991627,70054910 ,70117246,70195669,70219408,70258672,70367631,70561178,70619275,70751275,

70776876,70795615,70832580,70858756,70906359,70964750,70991337,71013052,7 1015131,71047735,71054305,71095451,71151654,71155921,71180750,71276015,71 311248,71387093,71387774,71402356,71446789,71490437,71530221,71577302,716 25607,71822686,71842390,71848921,71891958,71905410,71936611,71994082,7205 7731,72131620,72793036,72831177,72908245,73343329,73503472,73521180,73553 998,73603758,73637835,73667060,74995475,76054123,78367551,78395973,784437 00,79320270,79380878,79398101,79424761,79454982,79481297,79554633,7959238 5,79640736,81969530,82076776,82107268,82257310,82338356,82388868,84204724 ,84479494,84506012,84540934,84668342,84699375,84739181,84802297,84831860, 84892620,84919733,84943930,85153119,85185474,85427691,85766847,85805982,8 8445889,88446029,88459665,88463451,88507732,88531716,91829323,91849339,91 882496,91910183,91938831,91987882,92031586,92085045,93084997,93111001,931 76205,95616085,95681597,95703034,95735183,95777318,95956830,96335003,9635 4455,96423782,96991874,97042907,97078099,99273975,99486038,99595289,10168 5691,101951390,101975140,101990394,102607604,102726338,102730068,1027571 13,102780833,102891752,102917436,102940183,102996899,103036915,103563024, 103605121,104171455,104182857,104370850,104406187,104449487,104522080,10 4935835,106101178,106162405,106247887,106273523,106294933,106314703,1063 48964,106366532,107895812,110939421,110973846,111239821,111319724,111541 901,111707754,111737115,111889541,112009414,112146555,112281013,11256910 3,112674357,112958713,113152097,113223989,113269412,113337163,113458677,1 13538033,113740467,114487020,114553298,114571705,114732927,114738893,116 372003,116452575,116503797,116560327,116631646,116785387,116809145,11687 6272,116927066,116954032,117123376,117130846,117138820,117294504,1173736 18,117467125,117597460,117780274,117873951,117898620,117914894,117951150, 117991547,118471760,118598903,119157263,119206300,119223227,119284639,11 9387918,119561170,119677569,119709079,119764430,119764943,119831929,1198 63359,119934630,120228703,120910630,121008958,121082469,121271734,121317 075,121549483,121607861,121641625,121673600,121687174,122382229,12288796 3,122903468,122974833,122991279,123062594,123141687,123186215,123291506,1 23799974,123840588,123956749,124119388,124373456,124407676,124427306,124 582715,125302400,125486750,126269750,126550167,126833826,126935177,12695 3511,127016183,127182117,127225781,127339997,127385250,127402901,1274569 57,127508631,127677897,127807757,127832192,127918132,127993192,128026678,

129075202,129148984,129230513,129738566,130020047,130473914,130614785,13 0808545,130868486,131186232,131216574,131274394,132022207,132206589,1322 91061,132349736,133008572,133403334,133490463,133683261,133684321,133726

337.

Cr13:19527192,19557336,19580972,19621073,19702686,19745141,19839674,19844 711,19923557,20060963,20091266,20784332,20829582,20943224,21004618,210386 47,21086558,21116541,21168493,21206911,21285009,21322682,21355927,2142440 4,21494842,21525603,21570246,21627855,21753803,21779035,21801853,21822031 ,21866840,22768194,22788029,22961376,23014551,23039928,23040698,23061547, 23070641,23318543,23614167,23814442,24249957,24767989,24786047,26881949,2 6963698,26984194,27009440,27066253,27078719,27124201,27160941,27323607,27 403324,27458308,27489315,27522676,28198414,28232538,28262660,28736167,288 16278,29149430,29187988,29235883,30304716,30337216,30407398,30453522,3074 3469,30874175,30900868,30971421,31036365,31132712,31134432,31285532,31470 643,31588273,31642858,31664469,31688396,31713522,31806884,31823589,318593 78,32008008,32027764,32066605,32093710,32226399,32289705,33083371,3310287 6,33126737,33147052,33201966,33270351,33355337,33434913,33472683,33498170 ,33543287,33610711,33624345,33642016,33677971,33708662,33760818,33819325, 33907949,34043030,34061575,34117743,34423487,35288452,35495393,35540726,3 5571323,35590440,35681380,35709447,35748755,35766256,36196326,36377977,36 401731,36440404,36510728,36581177,37031396,37068104,37098420,37172926,372 55803,37311331,38233370,38269944,38275877,38305325,38347467,38350193,3843 6648,38562000,39544697,39649659,39685567,39751273,39783130,39810475,39891 818,40827346,42848853,42890109,42969646,42995262,43018177,43051804,430731 57,43488448,43518987,43574028,43603093,43644493,44225189,44812570,4487341 6,44876701,44899028,44911556,44984861,45242379,45384736,45463147,45528505 ,45544325,45696862,45895601,47116951,47212520,47215907,47252379,47342773, 47618634,47640810,48879935,48935423,48945148,49011087,49019389,49048757,4 9474722,49503260,50945600,50963551,50990737,51041227,51066171,53700585,53 743442,53759006,53790479,53853726,53915021,53962961,53986261,54045968,540 99849,54125392,54149773,54169824,54213345,54243889,54754531,54816106,5490 8675,54978163,55004448,55023669,58608409,58645129,59510412,59528155,59548 491,59648355,60766196,60977086,61150555,61187199,61226586,61251217,612737

88,61600357,61652128,61687150,61746802,62191363,62223560,62273122,6229823 8,62360366,62393583,63083359,63145579,63225163,63245011,63400527,63433191 ,63456730,63491298,63510449,64665185,64717517,66230607,66289335,66357648, 66440558,66494364,66533890,66613571,68465475,68595370,68654773,68790607,6 8858046,68921095,68942289,69789325,69805731,69845481,69907131,71362818,71 416511,71476541,71509401,71545354,71568719,71585114,71871605,71936872,733 15266,73418040,73575455,73691303,73857881,74396997,76362739,76467628,7661 5971,76653895,76672849,78403195,78461008,78470350,78472844,78491534,78499 569,78543721,78543895,78568738,78605431,78648023,78710028,78741620,789074 26,78951704,78984530,79012700,79039962,79109080,79354197,79436099,7954165 0,79651740,79756659,79839878,79880887,79903429,79921048,80008957,80046996 ,80054420,81009171,84438318,84490356,84521635,84654641,84703610,84705506, 84742185,84744158,84799548,84976063,85006611,85047253,86358118,86435490,8 6492492,86528417,86634242,86694993,86732433,87101629,87713434,88326177,89 053321,89259700,89839415,89999352,91856423,92053646,92134219,92152381,921 59443,92226609,92242350,92964282,93162061,93354092,93512943,93661774,9367 1514,93679183,93696337,93736849,93797347,93887975,93958432,94014625,94256 526,94589164,94798137,94981553,95053560,95618150,95794873,95894120,960051 28,96018546,96193889,97668063,97713383,97733272,97807422,98054592,9806120 7,98117164,98172508,98177939,98194569,98199525,98223320,98230575,98271386 ,98354891,98492934,98727052,98737123,98789027,98826997,99073062,99113471, 99157398,100286646,101041352,101065084,101101463,101321956,101368732,101 402878,101434042,101479359,102096574,102115620,102164566,102227495,10226 2930,102286595,102290452,103141574,103170387,103219191,104058106,1041182 82,104389933,105379728,105412886,105478259,105521735,105614657,105728682, 106872975,106893628,107044360,108233741,108264771,108327953,108360217,10 8393903,108458968,109282302,109300307,109326984,109432737,109500003,1096 46746,109679358,109783579,110012382,110054960,110076658,111702204,111771 371,113247331,113339761,113496566,113513682,113576453,113760034,11386715 3,113944932,113978690,114004301,114133640,114923885,114963757,115022014,1 15025398,115106996.

Cr14:20203125,20215448,20264019,20292485,20310923,20317747,20332855,20370 166,20374645,20409499,20417394,20419259,20467330,20515023,20669240,206942

72,21214023,22048414,22096824,22155396,22176920,22205447,22238121,2232832 1,22377373,22487698,22533887,22562282,22605746,22627848,23037397,23616784 ,25988491,26273882,26296706,26346323,26465052,26533549,26554990,26594900, 31293900,31316654,31343135,31465241,31584245,32245939,33299482,33445453,3 3502199,33531585,33585159,33607945,33681464,33746372,33829320,33846790,33 863165,34991625,35048345,35315334,35451365,35556498,35742486,36066989,363 27430,36609678,36632401,36664828,36899965,37016789,37190298,37350812,3740 7036,37963104,38032513,38074137,38111870,38174458,39316396,39691728,40163 510,40731102,40752906,40780715,40833156,40915940,40951650,40963604,409715 72,40997312,41288782,41327640,41372086,41408273,42728452,42743586,4283749 7,42871886,42892891,42934134,42966360,42986168,43051500,43072132,43122091 ,43152763,43219635,43307590,43324206,43399544,43546816,43611756,43617133, 43663316,43686961,43755602,43865089,44448083,44506760,44523467,44560198,4 4597628,44613305,44716083,44736406,45218049,45246155,45334026,45605818,45 755083,45834141,45870920,45940866,45962978,46050874,46173863,46218290,462 79473,46320159,46837139,46882764,47093881,47481897,47862477,47905339,4796 3471,47985282,48006709,48051690,48171330,48197659,48304718,48581065,49072 089,49718040,50074014,50164452,50204073,50237341,50254304,50357416,504041 82,50947548,51225724,51245120,51254908,51263413,51312785,51368495,5140016 0,51433884,51434056,51458728,52082136,52127059,52425639,52494707,52653889 ,53150374,53189731,53216723,53288450,53323211,53339777,53407575,53629907, 54136008,54313655,54331231,54348710,54418411,55149063,55841447,55881018,5 5932919,56026175,56101879,56180099,56246041,56419859,60829564,60887194,60 927248,60948318,60989784,61020617,61066248,61181894,61952839,62010799,620 33081,62259060,62361500,62386520,62403249,62458832,62482468,62562167,6259 0175,62727000,62777098,62796720,63164649,63169714,63192948,63213675,63288 002,63315265,63338563,64044097,64328776,64655161,65480197,65769417,658656 25,65914867,65934905,65960026,65980170,66005798,66076530,66403148,6689662 6,67886781,67943370,67964098,67979352,69068110,69190163,69422865,69561193 ,69594182,69610478,69641740,69664129,69681718,69721780,69752984,69771130, 70151933,70487396,71624424,71691495,72635437,73017126,73484384,73760442,7 3965574,75165825,75741751,75906938,76653626,76705850,76734188,76867629,77 018566,77038124,77039168,77061503,77094853,77116963,77132552,77490669,775 78367,77616002,77651418,77935940,78011994,78623134,78653922,78704596,7874

3322,78747216,78766644,78841183,78898025,78974225,79940383,80094078,80095 328,80128753,80914628,83153368,83176692,83607373,84098370,84338626,844055 96,84672038,84899437,85367699,85448621,85477753,85541011,85588026,8562049 9,85675016,85709382,85736868,85784598,86020289,86064367,86119802,86152846 ,86207490,86333324,86427943,86472124,86536505,86588032,86625952,86720031, 86799697,86817096,86875320,86898200,86923106,87468178,87508843,87552696,8 7741025,87769405,87795892,88715733,88777888,88894210,89063167,89105287,89 230364,89298288,89335613,89376563,89411434,89449492,89664199,89697121,897 14777,89722699,89745615,89834351,89904152,89926511,89952501,90002230,9004 6125,90123507,90190564,90288971,90427091,90868442,91593301,91608588,91657 549,91704722,91751274,92191350,92248885,92268531,92290744,92427126,935281 14,93788250,94000120,94076885,94121770,94773395,94916315,95011913,9510134 3,95126980,95157346,95299457,95364090,95426850,95480924,95559858,95588539 ,95748774,95792722,95820298,95846542,95871904,95967396,96091516,96116283, 96380651,96411518,96428578,96444081,96490610,96600631,96645037,97034805,9 7071607,97107157,97136353,97197783,97248740,97257326,97272382,97279220,97 301247,97365090,97419645,97446843,97480744,97522254,97554597,97571437,977 98875,97814106,97857732,97864929,97905325,97910897,97994090,98018394,9801 8493,98051842,98061173,98130071,98196333,98239057,98489306,98545464,98548 890,98576141,98591696,98615771,98631959,98642572,98647550,98654324,986581 19,98700611,98995186,99003134,99041675,99165987,99252003,99280484,9932254 0,99363644,100333862,100794404,101159416,102003172,102034366,102061858,10 2484565,102875200,103024387,103068112,103111823,103291031,103626006,1038 24721,103857537,103898525,103922390,104240618,104261723,104393932,104805 532,104866687,104915383,104978460,105016847,105067373,105213343,10526822 8,105365156,105404384,106760328,107003598,107045318,107070228,107140493,1 07154998,107160654,107170472,107176213,107216306,107263150.

Cr15:20851594,20871836,21200251,21895838,21924962,21950342,21973587,22041 650,22150464,22320057,22340626,22351239,22441711,22486763,22960868,229656 58,23701107,23755713,23868061,23894967,24036909,24446780,24470734,2454742 1,24647994,24666506,24727231,24788341,24846587,24897228,24927773,24958504 ,24991944,25137963,25196960,25230402,25254957,25279862,25295837,25355468, 25676467,25759391,26203835,26316806,26428488,26453592,26532333,26614810,2

6635248,26667141,26681670,26721087,26738785,26816588,26823404,26837651,26 867409,27159196,27178475,27220622,27279014,27756585,27866196,27970119,281 00943,28376910,28408573,29238339,29339947,29515658,30303775,30930500,3096 6896,31060003,31129630,31198929,31572976,31637996,31670675,31706775,31722 729,31745368,31764399,31791463,31819695,32324067,32387848,32403330,324035 31,32418291,32458661,33117280,33133073,33154897,33171372,33202425,3321856 1,33270370,33287881,33303405,33306560,33362646,33386299,33417073,34147309 ,34213394,34268616,34533980,34963375,35061777,35093043,35124070,35152649, 35177507,35326490,35608732,35686267,35706112,35812247,36039864,36158662,3 6235746,36251261,36291705,36553907,36605870,36656703,36741119,36784720,36 832625,36868112,36929369,37072299,37137376,37301565,37353240,37464467,374 94741,37675662,37742904,37778364,37822562,37923257,37962429,37985841,3811 3558,38909801,39034588,39065424,39099848,39146147,39227595,39248959,39282 766,39657646,39772759,39820603,39878275,39922086,40080692,40116727,401761 96,40179013,40199688,40519708,40556503,40700022,40841782,41456374,4149742 7,41545613,42816601,43090520,43380260,43473153,43528573,43579223,43620443 ,43772943,44188854,44272769,44620129,44756718,45018735,45526026,45731665, 45761193,45884854,45938661,45965441,46006320,46036121,46058488,46212872,4 6509229,46574981,46586343,46657050,46726707,46797725,46845278,46939780,48 039088,48261419,48688799,48734624,48856119,48891965,49162953,49216723,493 21529,49350419,49460463,49538159,49557933,49593733,49639468,49933144,4996 9299,50014077,50272085,50354578,51269629,51284680,51352249,51384194,51422 090,52144168,52175536,52713184,53101700,53406393,54020728,54041154,541046 09,54120538,54247196,54841874,54892404,54953104,54997299,55097497,5511348 6,55443674,55562142,55665089,55768094,55790691,55805122,55953600,56007695 ,56152872,56207983,57342699,57490605,57509961,57528500,57530475,57555798, 57581309,57604579,57608692,57659000,57733394,57782249,57868448,57898192,5 8070807,58471368,58505040,58592926,58614934,58645206,58751201,58799754,59 115159,59151010,59189972,59202217,59295925,59296076,59457376,59487930,601 43079,60358227,60444722,60462011,60489830,60546166,60549835,61436990,6239 4385,62445526,62709647,62862138,62872171,63056292,63164033,63213506,64508 763,64538524,64587735,64627303,66465264,67213830,67224701,67247947,672563 36,67287373,67299573,67363283,67382051,67401588,67446831,67485156,6749482 3,68079088,68183170,68377126,68467093,68566757,68610384,68626542,68651180

,68780263,68826856,68869582,68885583,69121107,69178312,69275988,70550428, 70578782,70611215,70626389,71909490,71952053,71958996,71977446,72006540,7 2022755,72119569,72174611,73989821,74125618,74143620,74224631,74312794,74 334038,74465548,75001230,75306795,75436455,75991451,76051706,76219765,762 42523,77085283,77670401,77808099,77986268,78073289,78304736,78374509,7844 7790,79924428,80072820,80208164,80373688,80405996,80470834,80583930,80627 908,81845153,81904379,82039728,82256077,82449906,82468650,82495610,825233 58,82573833,83346998,84027538,84201063,84225035,84254639,84273405,8429859 8,84321048,84362391,84563031,84616332,84779738,85103071,85171495,85361977 ,85379278,85581389,85624656,86230029,86358201,86390763,86606890,86676871, 86701116,87437869,87591686,87617527,87846085,89402925,89477225,89580299,8 9611160,89652552,89735248,89785811,89820514,89869329,90250479,90328551,90 461129,90619154,90703836,91882374,92088041,92115780,92537617,92665728,926 92946,92720600,92834585,92887994,92985006,93111587,93200452,93221596,9324 5099,93267336,93345092,93538430,93614127,93634724,93653581,93689193,93759 213,93930871,93932747,94007036,94009184,94029616,94063295,94142090,942106 45,94252515,94391572,94587417,94613425,94667872,95382263,95430965,9566664 8,95685639,95771824,95795765,95826797,95851099,95917000,96008531,96073547 ,96090152,96403310,96430634,96474791,96511463,96543074,96648248,97109503, 97356348,97475257,97546353,97732589,98516622,98539489,98583617,98599761,9 8772469,98801086,98876458,98896126,99266526,100974315,101110356,10130601 3,101527096,101559136,101734080,101869051,101903337,101955680,102052634,1 02101758,102104694,102153804,102204031,102243354,102277480,102305129,102 334857,102338427.

Cr16:86671,241210,262299,265159,293562,395396,547297,630902,985717,1045384, 1603576,1904239,2011126,2062065,2089006,2741812,2807263,2920764,2947014,2 963261,3027296,3056563,3084109,3101639,3225869,3274857,3277251,3391086,34 88773,3522303,3556484,3575270,3608256,3689678,3724352,4184764,4215719,546 6095,5483427,5571609,6016237,6059745,6170093,6481458,6659273,6758434,7102 285,7132999,7149352,7166948,7177220,7188323,7251807,7458329,7497460,75089 58,7527197,7664102,7695012,7716356,8304755,9654056,9684985,9808497,982164 1,9885027,10037474,10107669,10157081,10311067,11187783,11207894,11249329, 11285202,11309751,11337805,12301684,12357735,12482789,12708681,12718266,1

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Cr17:6689,73422,114669,173906,198072,503759,613501,719452,879151,948290,100 6446,1104720,1280195,1433758,1684953,1732300,1813900,1866892,1997444,3214 181,3279446,3312387,3449442,3475985,3719620,3763574,3818830,3839685,43233 36,4374569,4398442,4475244,4571939,4658971,4839033,4881434,4931553,495659 2,5281758,5317008,5529525,5555319,6297942,6421449,6473353,6557587,6575115, 6795648,6932140,6935261,6967051,7001578,7172631,7583083,7754460,7801082,7 888971,8014416,8068045,8347389,8630396,8850988,9157242,9233113,9336370,94 08609,9515777,9562546,9584146,9652499,9989937,10219366,10942098,10976886, 11017171,11073009,11101422,12380155,12399717,12436485,12531983,12549476,1 2589427,12625578,12713416,12868660,12918980,12993369,13039792,13097490,13 129143,13168040,13208676,13279256,13324290,13326466,13345571,13413641,134 36558,13500396,13689978,13727391,13790382,13845441,13867878,13964644,1400 4595,14024479,14221092,14311113,14336980,14366291,14404666,14420055,14450 777,14457283,14481709,14512525,15059318,15097156,15137606,15167975,151919 21,15225643,15296936,15382788,15399737,15614822,15798595,15810562,1582477 8,15869557,15903602,15936270,16008872,16216988,16357086,16383013,16454911 ,16509917,17087880,17544704,17646776,17896205,18278517,18367378,18532233, 18548418,18804199,19320495,19353378,19399223,19417728,19441220,19675104,2 0020364,20115315,20118499,20139090,20181566,20522444,20623988,20734795,20 924620,21087615,21133335,21245687,21707060,21845701,21909838,22019967,220 26080,22084950,22145506,25826128,25869008,26002324,26197769,26268925,2629 1904,26462138,27009749,27047489,27091951,27114600,27161138,27182944,27202 888,27249438,27361383,27409738,27499140,27591325,27596206,27610862,291144 63,29360004,29378892,29440554,29466722,29492423,29516113,29600564,2965288

4,29868140,29868448,29909428,29920940,29928083,29936995,29976650,30001953 ,30036578,30062860,30326360,30445984,30861865,31000816,31107845,31165058, 31201983,31239329,31443047,31493802,31541319,31567604,31640430,31676363,3 1703323,31735245,31773453,31805960,31857088,32001745,32047282,32102794,32 139062,32311028,32397162,32548517,32591666,32617437,32675472,32822378,331 79962,33205885,33392276,33433705,33485928,33516594,33539437,33539937,3356 7457,33574253,33600952,33641950,33770802,33876129,33940215,34017344,34040 786,34144460,34163565,34182341,34286745,34374462,34477386,34816256,348651 31,34910539,35237981,35444733,35460410,35491553,35550416,35577350,3588953 1,36026335,36059747,36078502,36123526,36170543,36223325,36234106,37150505 ,37273765,37532916,37583872,37696235,37830900,37843859,37863708,37922259, 37959598,37976469,38128765,38182844,38224498,38258246,38287070,38303547,3 8737379,38797242,38928456,38952254,39004460,39051261,39076616,39103542,39 139729,39154763,39185798,39323275,39409070,39441989,39470631,39487517,395 61910,39788675,39874075,39908770,39949516,39998141,40025264,40085665,4042 5320,40441819,40461674,41846582,42294337,42327556,42486973,42546874,42570 346,42647427,42754777,42774693,42814018,43195205,43459697,43655688,437414 52,43810371,43827209,43871147,43950976,43969779,43997520,44051924,4405683 3,44104509,44135827,44157597,44165098,44194735,44214888,44236725,44274560 ,44288579,44351686,44364829,44808902,44989888,45034002,45063349,45095678, 45166056,45187429,45228560,45264380,45267985,45307928,45416997,45444868,4 5479446,45503539,45683125,45702099,45755810,45852354,45872929,45904886,45 948412,45985414,46007029,46035930,46056995,46077882,46097878,46120767,462 51391,46318175,46418589,46568155,46668002,46807134,47115038,47183320,4719 2620,47208076,47218999,47240493,47270109,47278643,47279762,47547111,47880 427,47942375,48356996,48411972,48445192,49051851,49108661,49147686,492276 06,49291302,49363547,49738719,49760728,49777513,50072245,50113517,5017318 4,50224898,50255488,50282834,50299809,50328457,50354558,50375597,50393377 ,50444405,50494613,50530213,50602800,50728873,50923040,50996022,51142920, 51181879,51218910,51253765,51271626,51377020,51537585,51862803,52089407,5 2308825,52529201,52560339,52565704,52595418,52634726,52972247,53058202,53 063743,53212053,53230722,53263207,53419715,53514532,53665805,53696402,537 55360,54048741,54334732,54370517,54408083,54449676,54484989,54612445,5469 5401,54744011,54789359,54792751,54842555,54863448,54899945,54946194,55501

831,55697803,55886840,56192845,57013803,57769198,57934995,57938499,580324 48,58251249,58325868,58361274,58409634,58636463,59098340,59150233,6132627 1,61341314,61426698,61639694,61687600,61724695,61763031,61782920,61812655 ,62124998,62286590,62495009,62541309,62569580,62939167,63059721,63101258, 63197920,63794795,63835541,63853790,64200241,64419349,64454960,64481524,6 4510410,64567162,64600459,64727631,64745690,64808303,64922656,65082019,65 422143,65554289,65881959,65994679,66015963,66062316,66108989,66144402,661 54676,66478633,66812495,66870230,66971898,67017930,67043636,67081732,6735 1565,67403192,67481984,67482314,67636858,67714270,67810141,67876646,67972 672,68177765,68195046,68237670,68275532,68309320,68326338,68342647,684309 39,68447186,68657824,68668429,68695559,68707044,68723263,68784626,6879996 9,68825084,69395444,69435663,69482953,69535201,69628549,69689109,69732081 ,69757690,69783856,69856464,69979807,70058872,70130892,70161079,70208672, 70243611,70258662,70292762,70445988,70599924,70708074,70751444,70802589,7 0879560,71065399,71256018,71298458,71316114,71429361,71467391,71500251,71 889255,72278798,72600004,72950927,72981775,73011567,73302323,73553928,736 50686,74212382,74466973,74568507,74601276,74629867,74926605,75077220,7511 5626,75156011,75220287,75596112,75671260,75720303,75734511,75922557,75961 513,75998236,76087178,76564311,76703516,76729757,76813382,77160151,771763 51,77229462,77331446,77411247,77489075,77538517,77654711,77698582,7772358 4,77756364,77781725,77950014,78066617,78193252,78583871,78610388,78670328 ,78726575,78784925,79001300,79156551,79246605,79323081,79641486,79693136, 80008392,80071049,80114252,80573272,80588575,80937305,80958632,81045722.

Cr18:11543,86693,136305,196829,218285,252038,341466,415105,505472,527473,56 5414,628980,661005,668376,774499,877772,902328,933680,983188,1017892,13242 88,1344802,1391570,1414472,1441750,1476737,1587735,1660497,1722427,218748 9,2266977,2463095,2778382,2873900,3321039,3406933,3497714,3539135,3746998, 3840072,3848826,4019209,4125708,4147742,4749982,4951802,4976160,4979713,5 091704,5145389,5156040,5233414,5417253,5533188,5560258,5592779,5645281,56 75166,5903698,5955181,5976903,6008734,6043257,6079587,6107709,6155114,626 4811,6300697,6330902,6365614,6517834,6603954,6629449,6737787,6815657,6884 050,6936251,7027977,7063196,7146454,7164754,7166681,7202739,7221729,72559 21,7366642,7396038,7452614,7507983,7589318,7699817,7734378,7758916,781888

7,7851245,7870864,7909131,7930834,7990780,8035339,8078390,8166237,8204982, 8297998,8344040,8361185,8454501,8523943,8540316,8854219,8869780,8892906,9 015886,9099554,9121883,9244546,9575419,9621305,9661222,9756056,9800264,98 48613,9869865,9963086,9994685,10041354,10117473,10148722,10197500,1049202 3,10525480,10539774,10557670,10645713,10662515,10680810,10827974,10853771 ,10914871,10970976,11034100,11057865,11086602,11244106,11290068,11373580, 11412212,11546096,11553842,11671934,11774500,11802991,11884937,11930945,1 1945481,12080173,12400284,12486158,12802416,12998355,13066123,13133577,13 221234,13313114,13433610,13450974,13503887,13744968,13810828,13882198,139 31827,13982999,14021962,14055454,14144777,14183414,14205995,14227620,1434 8756,14376731,14583728,14715283,14829008,14888726,14938839,14961870,15028 265,15049329,15069726,15138031,15182454,15215871,19025501,19073953,190988 94,19107091,19423003,19589336,19627126,19670146,19826742,19827473,1985265 9,20015975,20079239,20145379,20188237,20263988,20451030,20490087,20544971 ,20566973,20647291,20904406,20946796,21350435,22159375,22330670,22371153, 22437188,22476929,23286020,23335325,23352995,25350685,25408173,25986410,2 6008276,26127280,26225084,26246051,26344393,26361906,27549306,27616586,27 783263,27844056,27987508,28025804,28054109,28936833,28964668,29038536,290 83016,29274349,29548754,29554990,29665712,29768913,30030522,30084085,3045 6257,30479190,30670021,30769471,31009751,31023564,31208453,31239694,31310 416,31324056,31343347,31374094,31383571,31401850,31426113,31599259,316625 06,32054724,32092922,32108520,32151415,32325314,32344890,32422326,3272195 1,33018819,33046674,33153396,33227581,33244028,33609053,33920063,33950996 ,33987212,34143431,34204260,35933124,36026976,36078516,36142935,36195762, 36237678,36422503,36451018,36469450,36536712,36569997,36598772,36610569,3 6860189,36885075,36924065,36946528,36964398,37259837,37292998,37346404,38 242063,38269498,38368254,38422096,38460348,38482815,38643072,38792674,391 13436,39121488,39130908,39163072,39164485,39254020,39334341,39398768,3942 6922,39502404,39554939,39576105,39740339,39811517,39880530,39913180,39937 509,40058893,40179527,40282106,40365619,40391686,40409146,40431879,404835 81,40503298,40548004,40674541,40697340,41762591,41904325,41924037,4203401 8,42055610,42099187,42612091,42629067,42677600,42709943,42751809,42799809 ,42855384,42990841,43033662,43084185,43133412,43313367,43502190,43671240, 43718658,43773903,43911448,43958173,44951355,45016669,46222342,46282982,4

6584184,46608271,46634754,46653380,46695549,46750593,47917735,48374186,48 472082,52889967,52896509,53135894,53165959,53177208,53302321,53303142,534 16114,53664282,55143279,55148861,55172294,55188918,55350459,55358917,5562 4434,55645543,55808073,56479000,57246293,57263048,57309059,57519110,57537 943,57649538,57775684,58426332,58477361,58570226,58589127,58613447,586610 59,61243483,61390332,61421541,61528848,61561211,63895063,63908561,6391214 2,64313945,64346592,64455253,64480206,64999149,65043085,65119714,65562335 ,65597922,65699571,65865039,66700252,66803950,66926506,67016267,67054127, 67073366,67111228,67133452,67190086,67209779,67260035,67286974,67304536,7 1259068,71332360,71400075,71501992,71520398,71574366,71727606,71774786,71 800264,71808829,71816411,71837113,71937252,72004071,72104182,72143386,723 44223,72395492,72483828,72594505,72774528,72777472,72874304,72887112,7289 7846,72975955,73044411,73063474,73089860,73131476,73236124,73311602,73358 207,73437873,73442451,73471051,73531933,73548125,73598516,73658936,736800 98,73753411,73961500,74381141,74441415,74678490,74701642,74722703,7490446 1,75015563,75081290,75185389,75541168,75938925,76025123,76055908,76059948 ,76097610,76652426,76735000,76886701,77413729,77455690,77485167,77521740, 77585701,77845882,77859855,77882568,77893683,77927028,77967972.

Cr19:260912,335055,389397,415294,482221,538160,939673,1933930,1937178,2120 154,2239966,2413228,2728577,2754548,2754840,2823269,3481578,3589074,36640 94,3705660,3877749,3902722,4140563,4182939,4416411,5039135,5235958,530834 7,5423643,5609257,5625802,5671821,5823903,5839746,5865837,5962530,6059840, 6158492,6552386,6742864,6961182,7011766,7083629,7103316,7129086,7480701,7 499771,7520217,7544588,7574918,7608428,7781435,7852337,7905019,7954240,80 28544,8096158,8136027,8921486,9057687,9075021,9110979,9379628,9474633,950 8228,9805692,10194884,10255112,10277799,10318080,10369086,10403947,104295 66,10449665,10467744,10546771,10621208,10645495,10752968,10772685,1079014 3,10837677,11434505,11476784,11498174,11568611,11596297,11657059,11697411 ,13564865,13584855,13940838,13947292,13996587,14624213,14644804,14664144, 14684425,14701093,14742924,14743902,14770671,14796884,14838552,14884841,1 4934891,14985805,15159981,15756971,15766419,15824071,15859629,15997564,16 022000,16051902,16167963,16184052,16234537,16282131,16300299,16339715,163 52403,16399051,16612011,16628850,16699813,17003789,17152552,17182017,1722

4329,17246212,17261240,17571138,17628352,17660608,17667970,17670975,17680 101,17713515,17762890,19519568,19567248,19723215,20209589,20291263,224703 68,22494878,22600546,22634929,22688517,22718556,23176271,23495001,2351704 6,23562729,23640795,23923949,24006274,24045852,24079561,24175078,24241624 ,24340502,24342584,24372161,28614693,28701767,28796676,29083784,29106772, 29320254,29382978,29460240,29482011,29514227,29551610,29556972,29587469,2 9676774,29697907,29762562,30071287,30090883,30192505,30325332,30495535,30 741623,30779475,30843906,30875521,30880839,30939443,31078219,31094463,311 15081,31137636,31243102,31261801,31279584,31292818,31314256,31346535,3165 4211,31689154,31734701,31890250,31932602,32003668,32361431,32761461,32781 705,32828993,32864565,32952454,33028014,33035849,33049943,33123576,331543 11,33594023,33615122,33647379,33680782,33848777,33899909,34006380,3466829 4,34682013,34704129,34723732,34775453,34808949,34844563,35130121,35278667 ,35338256,35381852,35797916,36721368,36739067,36758897,36901010,36938594, 36964781,36979961,37123595,38169355,38250824,38282158,38384421,38426985,3 8476683,38500703,38587463,38673298,40162593,40200508,40245690,40360928,40 404633,40443858,40861724,40880127,40907408,40933981,40982375,41006426,418 69468,41923314,41953430,41987873,42036793,42062307,42095969,42130776,4215 2229,42672760,43197581,43351164,43432017,43471565,43670595,43703455,43731 159,43753478,43937240,44012880,44030998,44076164,44105462,44124735,441639 54,44196226,44262545,44281562,44331613,44339377,44374716,44411543,4448270 7,44670302,44847800,44875317,44955113,44970935,45009690,45022697,45042516 ,45074177,45098531,45457105,45603936,45683448,45737218,45770763,46045905, 46117413,46244168,46288706,46327709,46334955,46431638,46616909,46640551,4 6674011,46782577,46806630,46906997,46959007,47020564,47393792,47470536,47 853157,48162750,48581142,48656624,48680524,48715269,48748003,48841185,490 39803,49191800,49241151,49307848,49388654,49701980,49801506,49940131,4999 1789,50380858,50417490,50456518,50477675,50512033,50550811,50742242,50820 795,51371419,51491029,51748103,52018474,52027587,52037704,52127030,522200 19,52259571,52724027,52784905,53015742,53041995,53120559,53147770,5321236 1,53232128,53271005,53809034,54145953,54205234,54256959,54489487,54553697 ,54797055,54815093,54851922,54902385,54950224,54965860,54988060,55017416, 55042628,55098667,55142930,55157930,55665410,56139679,56193662,56220245,5 6265664,56319525,56976711,57060573,57088850,57162101,57184833,57215173,57

218918,57250898,57324340,57344913,57370055,57436396,57497927,57739247,578 65082,58002665,58025651,58058739,58134272,58337365,58495059,58578578,5872 6569,58745931,58767168,58807757,58940127,58986260,59003830,59039699,59058

083.

Cr20:61795,134476,188107,218783,356785,598278,598427,694894,743220,967957,9 83957,1233837,1364154,1371697,1419846,1472408,1528038,1659461,1675292,169 8963,1728718,1754969,1786726,1937475,1960313,2025036,2074922,2165326,2192 516,2196559,2284440,2300608,2400503,2417085,2476631,2654925,2713665,27463 54,2825051,2990206,3102998,3169729,3228423,3305240,3447224,3541633,360505 9,3614336,3842984,4073305,4085669,4101800,4209772,4247774,4289066,4352738, 4387440,4544193,4562141,4614486,4654135,4682507,4717456,4742282,4862642,4 910589,5039659,5262119,5279335,5332049,5378152,5428300,5608428,5647738,59 39727,6014954,6049356,6073493,6463617,6489010,6509880,6528208,6584196,662 0893,6652150,6711863,6807276,6838358,7226483,7275683,7306965,7447191,7622 826,7638703,7656210,7679577,7818261,7834237,7849927,7882106,7905050,10622 258,10637057,10639841,10640444,10644614,10650510,10973258,11100677,111999 73,11238791,11299789,11336439,12769934,12796624,12944539,13000057,1303996 2,13087735,13320424,13557267,13691562,13727864,15041361,15070049,15086442 ,15103600,15143806,15219500,15410067,15434681,15510929,15560116,15603872, 15638912,16532251,16559508,16609087,16630329,16709662,16740575,17017199,1 7111709,17128722,17154897,17339774,17474791,17504907,17568891,17682288,17 757315,17934321,18021459,18405681,18522933,18575417,18704367,18706738,188 85682,18950921,18968197,18988095,19184044,19421642,19481841,19547213,1958 2308,19602042,19698783,19726798,19752844,19774604,19861017,19958303,20026 994,20034495,20082067,20147304,20238950,20289413,20371406,20715617,207320 33,20753683,20821624,20964485,20980253,21168361,21196012,21302327,2131265 3,21554860,21918288,21999213,22296079,22766828,23099869,23100202,23259778 ,23360369,23400050,23486589,23521388,23591837,23647482,23812545,23859753, 23939277,24013201,24121103,24145613,24174028,24382313,24398140,24423416,2 4532613,24589790,24778455,24890945,24964722,25015492,25048940,25082256,25 130395,25232406,25378172,25506582,25599655,29437204,29529825,29560603,298 46303,29846402,29874664,29904145,29942695,30006309,30232289,30259246,3046 9970,30742996,30791341,31211735,31433190,31826027,31981849,32175836,32199

872,32218613,32318760,32339799,32482632,32622608,32898339,33713674,337592 72,33863633,34069370,34225302,34428078,34539327,34885607,35189175,3547071 6,36500313,36521569,36561196,36604698,36660832,36716942,36818329,36823666 ,36971119,36987660,36988354,37145104,37330809,37368269,37394032,37419415, 37460462,37620888,37796786,38611514,39713869,39736722,39910104,40120211,4 0199925,40229720,40355087,40396811,40464214,40585492,40678430,40768673,41 316491,41344789,41360964,41412265,41421036,41441873,41458371,41465142,419 44207,41965936,42012125,42049249,42074998,42171482,42294613,42357295,4242 4236,42452777,42657841,42668388,43095497,43141375,43180615,43234090,43287 105,43477423,43532438,43835232,44204771,44554686,45005430,45110957,455585 73,45604240,45637163,45673584,46061099,46061286,46086478,46108458,4623352 4,46302940,46327442,46539487,46566768,46810358,46828160,46863384,46887655 ,46911291,46965442,47343059,47430328,47750377,47797653,48049506,48266292, 48383859,48466885,48554977,48874377,48915780,49313194,49761134,49839890,4 9861609,49884094,50131999,50223975,50337509,50355633,50591183,50933737,50 957837,50963243,51005684,51007824,51279104,51518982,51632942,51730252,517 63765,51944661,51990379,51997277,52199495,52480975,52556423,52558687,5256 2178,52673296,52716084,52745040,52809296,52835292,52872692,52900152,52960 064,53256245,53319721,53380907,53448625,53485263,53805994,53829332,538960 38,53915234,53960021,54086996,54147848,54539547,54663195,54686017,5480570 4,54839262,54873707,54961463,55174841,55265904,55286814,55329376,55370853 ,55586326,55791938,55808880,55978998,56061854,56093335,56180563,56202047, 56373388,56519045,56570841,56658315,56814892,57618596,57652124,57726029,5 8080635,58215137,58236938,58265626,58344353,58399419,58414699,58577671,58 695025,58712457,59246260,59285178,59394915,59469127,59493703,59591960,596 38856,59753312,59853938,60040600,60057411,60087082,60400835,60467252,6048 6498,60815446,60880653,61152322,61406884,61520794,61541028,61591049,61666 805,61895920,62044369,62137648,62159468,62306208,62401143,62664636,627137 40,62776135,62841074,62872259,62894380,62906514.

Cr21:14369207,14410171,14595264,14635153,14652908,14691367,14739464,14756 361,14784285,14827698,14849628,14907589,15238121,15322836,15331425,155943 71,15644351,16079616,16457917,16545758,16596103,17121639,17305004,1732047 5,17344553,17348568,17410409,17658262,17661163,17685246,17701226,17718964

,17791751,17953516,17973030,18001143,18017766,18633839,18836059,19315942, 19338037,19365349,19388413,19504855,19563036,19668977,19713821,19780074,1 9842577,20303819,20407327,20546596,20645238,20685393,20722633,20743097,20 787303,20812503,20844749,20871584,20923493,20945097,20966716,20988681,210 23831,21058174,21098201,21162674,21835927,21911414,22047521,22904009,2313 0518,23615954,23775045,23831817,24400257,24590183,24638617,24987949,25114 927,26052171,26077616,26729539,26795758,26825565,26882706,26919416,269656 79,27023673,27043584,27084965,27241995,27429317,27450255,27520277,2764681 8,27663523,27720663,27729997,27806191,27847264,27878577,27911995,28026499 ,28058794,28210657,28258853,28282020,28330838,28383999,28446323,28632360, 28675757,28700828,28827690,28897174,28953657,29022289,29043216,29559644,2 9679687,29730039,29753011,29792118,30140178,30244877,30409057,30576097,31 017340,31270167,32528597,32844542,32908593,32961623,33490504,33537853,338 16589,33852188,33888393,33910122,33949423,34038983,34185288,34277208,3429 9157,34344133,34417101,34459394,34617729,34660192,34788686,34821570,35471 878,35476029,35481423,35535850,35539892,35559911,35585080,35611109,356399 74,35700484,35726226,35751241,35858654,35904697,35969900,35970712,3600379 8,36053643,36077744,36726236,36775722,36828384,37229724,37315979,37346157 ,37361113,37389617,37417489,37521278,37554341,37557870,37575535,37658509, 37705393,37807318,37936655,37938729,37987916,38092700,38184059,38223407,3 8297650,39515091,39601127,39626576,39663827,39679445,39722818,39815212,39 844982,39896856,40354444,40379489,40486507,40564202,40590899,40637521,406 46090,40663181,40693490,40713833,40748006,40997309,41016536,41053509,4108 2179,41146835,41224073,41268738,41326577,41382211,41431874,41464281,41479 698,41515029,41562848,41725303,42079067,42140070,42161844,42253585,422741 23,42462562,42567637,42586495,42629652,43677831,43716022,43848521,4392694 3,43991942,44039013,44078102,44092603,44098625,44139048,44142979,44196394 ,44286190,44306885,44432880,44618563,44703410,44730807,44934857,44950305, 45021210,45058776,45216987,45386559,45494183,45673649,46139210,46200581,4 6362483,46583016,46670812,46768492,46820082,46839904,46926002,47133983,47 190214,47369190,47661615,47735735,47762374,47800592,47897967,47927424,479 61711,47962186,48018543,48019239,48021655,48050388,48100155.

Cr22:17915430,18131431,18205430,18389082,19486600,19544112,19632365,19690 656,20031964,20068556,20113253,20140295,20168509,20199579,20758954,208218 74,20872855,20891928,21017884,21431054,21928916,22054607,22155119,2228451 3,22355496,22416664,22417696,22417829,22424302,22427560,22428873,22437655 ,22451477,22474910,22524871,22601814,22670081,22718635,22726968,22840280, 22917025,23255556,23300887,23335700,23363429,23430410,23505934,23568858,2 3666929,23826675,23826866,23827304,23829461,23834889,23835039,24022975,24 251517,24503987,24681579,24700854,25045872,25090768,25090811,25103024,251 05347,25106411,25158326,25234014,25275393,25304473,25334977,25468830,2547 3526,25488365,25506779,25630597,25707443,25878363,25905464,25919492,25936 299,26019540,26058622,26126903,26504002,26532347,26557486,26578221,268620 41,27038299,27252454,27316435,27332590,27360964,27380730,27444882,2745921 0,27491699,27492536,27523485,27584291,27715293,27747270,27814210,27862191 ,27962231,28011067,28075879,28293980,28313583,28461138,28490418,28576960, 28641134,28663405,28696368,28719656,28756581,28811488,29834766,29836926,2 9839168,29846339,29847722,29868855,29881828,30076720,30081715,30088039,30 088257,30846623,30846644,30854360,30854663,30855674,30975513,30978073,309 80922,30986172,30986350,30986565,30987960,32110163,32210763,32324140,3234 2976,32403318,32442261,32459451,32552082,32584710,32607057,32665789,32683 496,32761715,32793269,32812543,32875871,32963295,32987955,33104058,331678 51,33187342,33332712,33414164,33440219,33471598,33542464,33549485,3356096 0,33616088,33631908,33738865,33791374,33834668,33960548,34229105,34409899 ,34441926,34561720,34794787,34840736,34909613,34988577,35038036,35274183, 35292292,35339852,35371223,35412768,35465085,35580597,35595720,36272637,3 6334261,36572515,36657596,36732537,36741740,36746079,36758849,36759815,36 764534,36766003,36771232,36912724,36941065,36947624,36962766,36978325,370 08928,37085935,37117084,37166674,37316949,37366826,37400084,37582205,3759 8826,37613309,37668578,37692938,37717819,37720268,38242813,38426043,38787 939,38820595,39230064,39712314,39810379,39812409,39812986,39813948,398247 81,39997630,40000313,40034609,40069449,40086013,40105781,40124946,4016992 6,40208454,40351438,40825193,40873576,40900077,40971703,40996367,41050608 ,41107688,41889402,42005365,42163259,43040434,43064857,43082826,44163393, 44185977,44216801,44370439,44418039,44442441,44816607,44975456,45003878,4 5007348,45065866,45156255,45177040,45192660,45253872,45297719,45325461,45

331853,45525484,45577231,45731539,45865055,45908895,46891143,46919761,469 19906,46926482,46928266,47293288,47338438,48145834,48177285,48198112,4840 9068,48708059,48891519,48921825,48942566,49145300,49214032,49336433,49364 245,49380270,49398026,49506256,49532043,49568462,49613009,49650548,496812 55,49683905,49710060,49732073,49928589,50095813,50152568,50281917,5053259 8,50556736,50681029,50991205,51016098,51059118,51089213,51134186,51156666 .

CrX:156874,202439,219978,229542,296985,342775,403881,524464,547183,643862, 707050,920485,930802,1833138,1867483,1901503,2034752,2320028,2325651,2381 922,2452432,2492302,2535285,2565296,2627829,2628776,2735539,3030426,30665 05,3084785,3127322,3174698,3308214,3369880,3414710,3692817,3948553,398665 6,4053502,4306331,4426238,4647962,5201137,5819590,5992923,7784077,8313473, 8497324,8503491,8539504,8581060,8629668,8696916,10417020,10424485,1046778 8,10514451,10595454,10835429,13766163,13769452,13775368,13775930,13781774 ,13783934,14883948,15847887,15856587,15863296,15868480,15869313,17408971, 17471904,17573239,17597275,17692151,17729022,18453257,18494669,18498229,1 8585510,18592147,18666766,18673707,18678690,18679263,18686136,19368769,19 369095,19371862,19378385,19378784,20170527,20184037,20221809,20225193,202 33538,20275312,21962149,21972154,21984235,21985964,22004719,22008984,2205 6132,22092532,22142354,22227480,22235220,22265789,22325710,22504251,22656 818,22983765,23165329,23213761,23303624,24414279,24529193,24564100,268234 84,26883478,26913250,26948596,26988681,27046007,27105085,27241550,2755458 3,27594340,27612576,27935971,28141218,30459513,30480171,30526305,30592925 ,30622922,30673869,30724326,32757752,32785461,32941330,32993146,33041454, 33127746,33162533,33216851,35428941,35570398,35823308,35921591,36121706,3 6162480,36185269,36298580,36499315,36725214,37274356,39066324,39179872,39 249366,39493720,39514486,40427482,41329484,43045692,44988420,45574041,456 40507,46152647,47886996,48391429,48838445,49096067,49118461,49144114,4917 3299,49372144,49401262,49439482,50244281,50528333,50745333,50811387,50962 415,50999987,51317899,51609873,51697194,53256211,53302495,53687348,537441 16,54454152,54778440,55382061,55841702,56496191,56595791,56824154,5701986 2,57095458,57395124,57433303,57478582,57526389,57581725,57615050,57665107 ,57702973,57758527,57794329,57851350,57938692,57991672,58058877,58081014,

63242059,63316076,63395675,63548938,63570024,63617307,63635815,63811315,6 3916972,63970932,64072122,65535945,65765407,66238345,66337100,66360614,66 376616,66508386,67794536,67875148,68029074,68057610,68747247,68982626,704 03144,73042316,73042916,73043817,73046557,73053673,73066439,73655100,7366 5248,73679419,73699631,73718552,73747833,73988338,74007221,74048289,74100 589,74135172,74138231,74589117,74598687,74602347,74739847,74743194,767932 72,76802778,76843057,76848940,76875358,76877877,77231335,77268502,7727485 9,77277268,77360724,77371470,77372275,77379935,77381014,79925246,79940623 ,79966341,79994465,80033232,80058474,84360359,84409583,84465109,84523972, 84582791,84695468,84802575,84818371,84847413,85882350,86208976,86473035,8 6600304,86689560,86811800,88518437,91854274,92517724,92947672,93087238,93 481037,93569541,93734657,94453780,95094488,96060368,99902121,99903031,999 05245,99914295,99919733,99921385,100604681,100609547,100616989,100634252, 100639801,100640802,100656518,100657809,101090243,101090953,101091904,10 1099547,101100989,101102435,102191327,102524477,102611468,102897842,1029 75153,102979992,103246635,103682868,103754890,103931695,106573149,106947 997,107209879,107611024,107685542,108075242,108392551,108414092,10849919 8,108516163,108607079,108682301,108731203,108824447,108996570,109094393,1 09129790,109369916,109603183,109984315,110188612,110251592,110324989,110 359070,110395354,110459955,110540503,110575995,110581554,110616702,11062 1812,110632488,115304031,116906901,116960816,116978819,117043122,1170963 92,118089843,118275512,118968191,118968402,118969075,118985395,118985422, 118985598,119005587,119009236,119010427,119562718,119564881,119571058,11 9571073,119591135,119601053,119664787,119677888,119685868,119700082,1197 04083,122321206,122393107,122447489,122540205,122594223,122622851,123480 147,123488238,128676814,128702767,128708910,128721193,128725857,12872605 2,128938677,128959846,128960230,128967480,128970690,128975722,131211235,1 31236984,131305766,131333070,131543140,131617620,131636787,132693782,132 781982,132839999,132926592,133016268,133112360,133597240,133600986,13362 9514,135102090,135104864,135107008,135114785,135124043,135128488,1357528 08,135779440,135785119,135831361,135843880,135862727,136655146,137988003, 139265489,139288359,139405595,139441060,139507948,139542740,139597127,13 9615664,140943665,140945609,140948079,140953078,140953758,140953783,1421 14266,142600669,142802673,146607388,146666759,147085619,148268603,149182

284,149270442,149295271,149313435,150868017,150897049,151061939,15115267 7,151262143,151521271,151594821,151617341,151706961,151995786,152131542,1 52508909,152616701,152631557,152699719,152877997,153330042,153555386,153 725343,153886394,153907749,154173907,154280805,154345791,154375072,15441 7368,154435537,154454087,154752980,154789496,154844287,154915975,1551959

00.

CrY:2722506,2815303,2846401,2911033,3116790,3347234,3546605,3797733,40114 88,5171850,5272378,5560349,5586370,5677713,5950884,6039663,6073852,642252 5,6661973,6818291,6965215,7073423,7188146,7401836,7628484,7642823,7658027, 7714986,7835840,7891188,7963031,8046731,8214827,8334875,8360818,8502236,8 558969,8667179,8906357,9131385,9170545,9171683,13887941,13939607,13992338 ,14001232,14031334,14197867,14197977,14288981,14345705,14416216,14577177, 14641193,14664631,14804077,14813991,14838700,14850341,14901633,14924869,1 5472863,15983014,16301305,16578072,16699334,16713318,16773870,17495914,17 559652,17570599,18561042,18578476,18596847,19349615,19372700,19443641,195 63894,20804835,20834703,20837553,21086211,21528257,21604901,21674068,2172 2098,21730257,21872738,22072340,22672031,22725379,22746786,22928344,23473 201,23631629,23749182,23984056,24069943,24069946,24070105,24359931,244019 40,24475669,

Otra realización aún más preferida del método primero y segundo de la invención se refiere a ambos métodos donde la muestra se selecciona de la lista que comprende tejido, líquido cefalorraquídeo, mucosa oral, sangre, plasma, suero, linfa, liquido pleural y orina.

Otra realización aún más preferida del método primero y segundo de la invención se refiere a ambos métodos donde el sujeto es un humano.

Un tercer aspecto de la invención se refiere al uso in vitro del número de copias de las regiones cromosómicas de la invención como marcador diagnóstico o pronóstico de enfermedades genéticas o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética. Preferentemente, la enfermedad genética es cáncer o una enfermedad congénita. Más preferentemente, el cáncer es cáncer del sistema

nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemia linfática crónica, leucemia linfática aguda, mieloma múltiple o un síndrome mielodisplásico. Aún más preferentemente, el cáncer del sistema nerviosos central es glioma (bajo y alto grado), meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme. Preferentemente, la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.

Un cuarto aspecto de la invención se refiere a un array que comprende sondas que detectan ganancias y/o pérdidas de las regiones cromosómicas de la invención donde el número de dichas sondas diferentes se sitúa entre 10.000 y 20.000. Preferentemente, el número de las sondas diferentes se sitúa entre 14.000 y 15.000. Una realización más preferida se refiere al array donde las sondas se sitúan en un soporte sólido. El soporte sólido se refiere a cualquier soporte sólido conocido por el experto en la materia, por ejemplo de vidrio, nitrocelulosa o nylon; puede referirse, por ejemplo, a un portaobjetos de laboratorio. Las sondas pueden ser sondas polimórficas

o no polimórficas. Las sondas polimórficas también pueden ser sondas que detectan polimorfismos que están en el mismo bloque haplotípico. Una realización más preferida del cuarto aspecto de la invención se refiere a un array donde las sondas detectan los genes descritos en la tabla 1. Otra realización más preferida del cuarto aspecto de la invención se refiere al array donde las sondas detectan los polimorfismos descritos en la tabla 2. Los polimorfismos podrían ser polimorfismos correlativos a los indicados con un intervalo de más menos 200pb. Las sondas pueden estar repetidas en el array. El array del cuarto aspecto de la invención es un array de oligonucleótidos.

Un quinto aspecto de la invención se refiere al uso del array del cuarto aspecto de la invención para el diagnóstico o pronóstico de enfermedades genéticas o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética. Preferentemente la enfermedad genética es cáncer o una enfermedad congénita. El cáncer, preferentemente es cáncer del sistema nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemia linfática crónica, leucemia linfática aguda, mieloma múltiple o un síndrome mielodisplásico. El cáncer del sistema nervioso central es preferentemente glioma

(bajo o alto grado), meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme. La enfermedad congénita es preferentemente síndrome de Down, síndrome de Edwards o síndrome de Patau.

A lo largo de la descripción y las reivindicaciones la palabra "comprende" y sus variantes no pretenden excluir otras características técnicas, aditivos, componentes o pasos. Para los expertos en la materia, otros objetos, ventajas y características de la invención se desprenderán en parte de la descripción y en parte de la práctica de la invención. Los siguientes ejemplos y figuras se proporcionan a modo de ilustración, y no se pretende que sean limitativos de la presente invención.

DESCRIPCIÓN DE LAS FIGURAS

Fig. 1. Ideograma de cada cromosoma con el número de sondas totales de la invención en la parte superior y el número de sondas en cada banda cromosómica.

Fig. 2. Esquema del proceso de selección de las sondas para el array diseñado que incluye sondas que identifican los distintos segmentos afectados: A) con deleción homocigota y amplificación génica (densidad elevada de sondas en dichas zonas marcadas con círculos). B) sondas en las zonas de deleción heterocigota y/o ganancias recurrentes y C) sondas en las regiones proximales y distales de cada brazo cromosómico. Las flechas indican a modo de ejemplo regiones afectadas por alteraciones en el número de copias en distintos puntos a lo largo de ambos brazos cromosómicos. Las líneas paralelas en los extremos del idiograma de cada cromosoma y en la zona centromérica indican que se excluyeron dichas zonas.

Fig. 3. Detección de alteraciones que afectan a diferentes cromosomas en un meningioma realizado con el método de la invención: perdidas completas de los cromosomas 11 (A) y 22 (B), perdidas de un brazo de los cromosomas 1 (C) y 7 (D), y pérdida parcial en 18q (E).

Fig. 4. Detección de alteraciones heterogéneas del cromosoma 22 en meningiomas. En el panel A, pérdida del cromosoma 22 entero (monosomía 22) que puede aparecer como una perdida aislada, o en otros meningiomas aparece junto alteraciones de

varios cromosomas. En el Panel B, una pequeña ganancia a nivel de 22q (marcada con un rectángulo), y los paneles C, D y E muestran deleciones de gran tamaño y pequeños segmentos a nivel de 22q con dos copias (marcadas con un circulo).

Fig. 5. Detección de pérdidas homocigotas del gen CDKN2A en glioblastomas multiformes en el cromosoma 9p indicadas con flechas.

Fig. 6. Detección de amplificaciones (AMP) génicas en gliomas. Panel A: muestra AMP de EGFR sin ganancias del cromosoma 7. Panel B: AMP de EGFR junto a ganancia de cromosoma 7. En el Panel C: la AMP de EGFR aparece con ganancia de 7q. Panel D: presenta ganancias intersticiales a lo largo del cr7 junto AMP EGFR. Panel E: varias amplificaciones a nivel de 7p y ganancia del cromosoma 7 y panel F: muestra ganancias del cromosoma 7, sin AMP de EGFR y una AMP a nivel de 7q.

Fig. 7. Detección de patrones típicos de ganancias y pérdidas en los cromosomas 7, 9 y 10 en glioblastoma multiforme. Ganancias del cromosoma 7 sin amplificación del gen EGFR (paneles A, B, C y D) y con amplificación (paneles E y F) junto a deleciones del brazo corto del cromosoma 9 y perdidas a nivel del cromosoma 10 (observadas en todos los paneles).

Fig. 8. Detalles de la heterogeneidad de los cromosomas 7 (columna A), 9 (columna B) y 10 (columna C) en glioblastomas, con ganancias a nivel del cromosoma 7 (con dos subgrupos de tumores: los que no amplifican EGFR –subpaneles 1 al 4-y los que si presentan amplificación génica -paneles 5 y 6-), deleciones a nivel de 9p y pérdidas a nivel del cromosoma 10 (generalmente monosomía 10).

Fig. 9. Esquema de los pasos seguidos en el diseño de la invención.

Fig. 10. Comparación de los perfiles del cromosoma 7 con arrays comerciales frente al array de la invención. A, C, array de la invención; B, array comercial GeneChip Human Mapping 500K set de Affymetrix; D, Genome-Wide Human SNP Array 6.0 de Affymetrix. Detección de una deleción parcial del cromosoma 7 (A y B). Detección de una ganancia del cromosoma 7 junto amplificación del gen EGFR (C y D)

EJEMPLO

A continuación se ilustrará la invención mediante unos ensayos realizados por el inventor, que demuestran la eficacia del método de la invención la identificación de alteraciones en el número de copias en los 24 cromosomas

Ejemplo 1: Obtención del método de la invención de detección de cambio de número de copias en todos los cromosomas en tumores del sistema nervioso central.

Se estableció el número de copias y los perfiles de cada cromosoma (Figura 1 y 2) en tumores del sistema nervioso central, meningiomas benignos y malignos, y glioblastomas multiformes (GBM) detectando las pérdidas (Figuras 3 y 4) de material genético de distintos tamaños que van desde la afectación de la totalidad de un cromosoma, uno de sus brazos afectados, o deleciones intersticiales, así como información de genes afectados por deleciones (homocigotas y/o heterocigotas) (Figura 5), amplificaciones génicas (Figura 6) y ganancias (Figuras 7 y 8).

Se fijaron las posiciones físicas para los 24 cromosomas, utilizando las regiones distales y proximales de ambos brazos de cada cromosoma excluyendo las regiones pericentroméricas y microsatelites que permiten detectar monosomias y poliploidias que afectan a un cromosoma completo o a un brazo entero (brazo p o q del cromosoma) (Figura 2).

Para las pérdidas y ganancias intersticiales de gran tamaño (que afectan a la mitad del brazo, a una cuarta parte, o a tres cuartas partes de cada brazo del cromosoma se identifican en cada brazo las zonas afectadas y se utilizan sondas en esas posiciones físicas), así como en las regiones (perdidas y/o ganadas) de tamaño pequeño, regiones comunes y recurrentes detectadas en cada cromosoma que han sido identificadas en diversos tipos de tumores.

Las regiones de amplificación génica y deleción homocigota llevan una mayor cobertura, aumentando la densidad de las sondas en las posiciones físicas que ocupan y cubriendo los distintos tamaños de estas alteraciones (Figura 2).

El array se estabiliza con sondas en todas las bandas cromosómicas (pueden ser varias sondas). Se seleccionaron 14.933 sondas repartidas en los 24 cromosomas, que son suficientes para identificar las alteraciones del número de copias (Tabla 4)

Tabla 4. Número de sondas utilizadas en el nuevo array objeto de la invención y su distribución en los 24 cromosomas comparado con dos arrays comerciales. (--) significa que no hay sondas para ese cromosoma o ADN y MT significa mitocondrial.

Cromosoma

Nuevo array Arrays comerciales

Secuencias

Genes Secuencias Genome-Wide Human SNP Array 6.0 array Secuencias GeneChip Human Mapping 500K

1

1519 459 71.312 40.203

2

890 260 73.937 41.395

3

848 214 60.685 33.792

4

675 204 55.995 32.316

5

611 168 56.416 32.053

6

665 170 56.271 31.466

7

786 175 47.056 25.830

8

494 113 48.608 27.454

9

1045 192 41.442 22.859

10

683 172 48.195 28.497

11

624 150 44.539 26.269

12

857 205 42.555 24.948

13

472 71 34.283 19.184

14

504 106 28.065 15.717

15

510 143 26.074 14.349

16

428 156 27.716 15.309

17

666 207 20.658 11.277

18

518 92 26.529 14.880

19

430 210 11.929 6.396

20

480 137 22.843 12.398

21

290 76 12.579 7.124

22

324 99 11.537 6.206

X

511 123 36.886 10.525

MT

- - 119 --

TOTAL

14.933 3920 906.487 500.447

El array se compone de un total de 14933 sondas de las cuales 7201 son secuencias en el interior de 3920 genes.

Las sondas comerciales que se utilizaron se señalan a continuación (tabla 5):

SNP_A-8575395, SNP_A-8709646, SNP_A-8497791, SNP_A-1677174, SNP_A-2116190, SNP_A-4291020, SNP_A-1902458, SNP_A-2131660, SNP_A-4277872, SNP_A-2118217, SNP_A-1884606, SNP_A-2169457, SNP_A-2235839, SNP_A-2218153, SNP_A-2223642, SNP_A-1799863, SNP_A-1908463, SNP_A-1955996, SNP_A-1718890, SNP_A-2082194, SNP_A-2135694, SNP_A-1789472, SNP_A-1934233, SNP_A-4207031, SNP_A-2179242, SNP_A-1783583, SNP_A-2115409, SNP_A-2116785, SNP_A-1678466, SNP_A-1681384, SNP_A-1879486, SNP_A-1897613, SNP_A-1668776, SNP_A-1642581, SNP_A-1723597, SNP_A-1718237, SNP_A-1828771, SNP_A-1895403, SNP_A-1930492, SNP_A-2237566, SNP_A-2258506, SNP_A-1701872, SNP_A-1930718, SNP_A-1705537, SNP_A-2278622, SNP_A-1960639, SNP_A-2022696, SNP_A-2262266, SNP_A-1670878, SNP_A-2212837, SNP_A-1646481, SNP_A-1666738, SNP_A-2181437, SNP_A-1686722, SNP_A-1705703, SNP_A-4282340, SNP_A-1749896, SNP_A-1714480, SNP_A-1667950, SNP_A-2129718, SNP_A-2175833, SNP_A-1745466, SNP_A-1739955, SNP_A-1743804, SNP_A-1952660, SNP_A-2223437, SNP_A-2224099, SNP_A-2170486, SNP_A-1743594, SNP_A-1676349, SNP_A-2058862, SNP_A-4224138, SNP_A-1656665, SNP_A-2050345, SNP_A-1873575, SNP_A-1673751, SNP_A-1879594, SNP_A-2100113, SNP_A-1796045, SNP_A-2220372, SNP_A-4242443, SNP_A-2243080, SNP_A-1842009, SNP_A-1699284, SNP_A-1891001, SNP_A-1924336, SNP_A-1643131, SNP_A-4278685, SNP_A-8470497, SNP_A-1818172, SNP_A-4250097, SNP_A-2207883, SNP_A-1868600, SNP_A-1684527, SNP_A-2165491, SNP_A-1666985, SNP_A-2185717, SNP_A-2251186, SNP_A-1652193, SNP_A-4230374, SNP_A-4194252, SNP_A-1683825, SNP_A-1691698, SNP_A-1687843, SNP_A-1687400, SNP_A-1671386, SNP_A-1671445, SNP_A-1808066, SNP_A-4274938, SNP_A-2167266, SNP_A-2095667, SNP_A-1711211, SNP_A-1711739, SNP_A-2300181, SNP_A-1681341, SNP_A-2113625, SNP_A-2111308, SNP_A-1881321, SNP_A-2057029, SNP_A-2042477, SNP_A-2314431, SNP_A-2236812, SNP_A-1750171, SNP_A-2188347, SNP_A-1661146, SNP_A-2233462, SNP_A-2287787, SNP_A-2187559, SNP_A-1718632, SNP_A-1929772, SNP_A-1726085, SNP_A-1948295,

SNP_A-1654229, SNP_A-2255111, SNP_A-2185703, SNP_A-1686500, SNP_A-1717751, SNP_A-1697953, SNP_A-1664654, SNP_A-1756835, SNP_A-2298894, SNP_A-2176916, SNP_A-2025605, SNP_A-1852210, SNP_A-1945628, SNP_A-2151539, SNP_A-2259810, SNP_A-1813299, SNP_A-1959830, SNP_A-2263001, SNP_A-2173869, SNP_A-2300283, SNP_A-1646710, SNP_A-1782600, SNP_A-1960638, SNP_A-1781313, SNP_A-2121430, SNP_A-8298421, SNP_A-1754728, SNP_A-2115002, SNP_A-1799366, SNP_A-1706913, SNP_A-2250990, SNP_A-1815621, SNP_A-4300773, SNP_A-1909176, SNP_A-1677240, SNP_A-4194375, SNP_A-4207490, SNP_A-8367856, SNP_A-4196950, SNP_A-1798804, SNP_A-8443077, SNP_A-2264437, SNP_A-1845603, SNP_A-1939799, SNP_A-2059135, SNP_A-1895449, SNP_A-2218894, SNP_A-1652320, SNP_A-1963782, SNP_A-1682449, SNP_A-1723002, SNP_A-2312971, SNP_A-1693483, SNP_A-1964871, SNP_A-1999893, SNP_A-1687849, SNP_A-1937874, SNP_A-1693165, SNP_A-1795578, SNP_A-1841240, SNP_A-1683515, SNP_A-1726304, SNP_A-1744558, SNP_A-1705081, SNP_A-1674190, SNP_A-2278487, SNP_A-1782464, SNP_A-1956385, SNP_A-1801052, SNP_A-2048263, SNP_A-1691431, SNP_A-1665880, SNP_A-1856143, SNP_A-1872931, SNP_A-1734347, SNP_A-1723341, SNP_A-1726821, SNP_A-1697551, SNP_A-1726011, SNP_A-1673750, SNP_A-1895297, SNP_A-4282720, SNP_A-1741853, SNP_A-1712561, SNP_A-1669999, SNP_A-1674383, SNP_A-1673838, SNP_A-1752247, SNP_A-1749256, SNP_A-1673926, SNP_A-1709273, SNP_A-1655289, SNP_A-1723021, SNP_A-1728312, SNP_A-1666311, SNP_A-1646335, SNP_A-1703512, SNP_A-1728267, SNP_A-1757692, SNP_A-1650897, SNP_A-1678616, SNP_A-1755243, SNP_A-1662223, SNP_A-4236362, SNP_A-2235940, SNP_A-2037804, SNP_A-2300090, SNP_A-1915583, SNP_A-2121853, SNP_A-1892255, SNP_A-4273111, SNP_A-1653089, SNP_A-4211081, SNP_A-1660258, SNP_A-1701699, SNP_A-1715345, SNP_A-1699617, SNP_A-1745139, SNP_A-4251587, SNP_A-8291532, SNP_A-1746524, SNP_A-4202677, SNP_A-2236414, SNP_A-4211511, SNP_A-1731929, SNP_A-1792267, SNP_A-4295032, SNP_A-1819207, SNP_A-1757353, SNP_A-2186095, SNP_A-2308314, SNP_A-1708186, SNP_A-2039420, SNP_A-1652606, SNP_A-2128216, SNP_A-2213242,

SNP_A-2163486, SNP_A-1704403, SNP_A-1697051, SNP_A-1740568, SNP_A-1678809, SNP_A-2069878, SNP_A-1657323, SNP_A-1665257, SNP_A-2125613, SNP_A-2282881, SNP_A-1658232, SNP_A-1999950, SNP_A-1758455, SNP_A-1718217, SNP_A-1657166, SNP_A-1680027, SNP_A-1642665, SNP_A-1687098, SNP_A-8659701, SNP_A-1643473, SNP_A-8572253, SNP_A-8526670, SNP_A-8531792, SNP_A-1958834, SNP_A-1934733, SNP_A-2051598, SNP_A-4238296, SNP_A-4226678, SNP_A-2300840, SNP_A-1993283, SNP_A-1652712, SNP_A-1669337, SNP_A-1671442, SNP_A-2200991, SNP_A-2255710, SNP_A-2228635, SNP_A-1920964, SNP_A-4213904, SNP_A-2247903, SNP_A-1999970, SNP_A-2212290, SNP_A-4283138, SNP_A-1720070, SNP_A-1722275, SNP_A-1725943, SNP_A-1893286, SNP_A-1658147, SNP_A-1997445, SNP_A-1666641, SNP_A-1831518, SNP_A-2116452, SNP_A-1698274, SNP_A-1683105, SNP_A-1823937, SNP_A-2200065, SNP_A-1808252, SNP_A-1653165, SNP_A-1831333, SNP_A-2251227, SNP_A-1711805, SNP_A-1684602, SNP_A-1659931, SNP_A-1749045, SNP_A-4194567, SNP_A-1701720, SNP_A-1752726, SNP_A-1655991, SNP_A-2105042, SNP_A-2067488, SNP_A-4224911, SNP_A-1750225, SNP_A-1682872, SNP_A-1707710, SNP_A-1751754, SNP_A-1741706, SNP_A-1752286, SNP_A-1683393, SNP_A-1757722, SNP_A-4249452, SNP_A-1688881, SNP_A-2224354, SNP_A-2121225, SNP_A-1744850, SNP_A-1752120, SNP_A-2118379, SNP_A-2069002, SNP_A-1704069, SNP_A-1673699, SNP_A-2064092, SNP_A-1680369, SNP_A-1706077, SNP_A-1672650, SNP_A-4257891, SNP_A-4251958, SNP_A-1680196, SNP_A-1691785, SNP_A-1661175, SNP_A-1705109, SNP_A-1664811, SNP_A-1668237, SNP_A-1724643, SNP_A-1660594, SNP_A-1749956, SNP_A-1735403, SNP_A-1743516, SNP_A-1725807, SNP_A-2036213, SNP_A-2003050, SNP_A-2260782, SNP_A-4230632, SNP_A-2252959, SNP_A-2163195, SNP_A-1846284, SNP_A-2216152, SNP_A-1793126, SNP_A-2299988, SNP_A-1887977, SNP_A-4214300, SNP_A-4229541, SNP_A-2109120, SNP_A-1870994, SNP_A-1729743, SNP_A-1663743, SNP_A-1654542, SNP_A-1700078, SNP_A-1753902, SNP_A-1702410, SNP_A-1658183, SNP_A-1666859, SNP_A-1714169, SNP_A-1659133, SNP_A-1702918, SNP_A-4214434, SNP_A-1716820, SNP_A-1895715, SNP_A-2286111,

SNP_A-2175629, SNP_A-1702044, SNP_A-1750774, SNP_A-1699224, SNP_A-4196087, SNP_A-2301448, SNP_A-1927163, SNP_A-4194961, SNP_A-2090623, SNP_A-1654970, SNP_A-2073220, SNP_A-2099928, SNP_A-2066744, SNP_A-1888278, SNP_A-2054976, SNP_A-2030310, SNP_A-1928430, SNP_A-1791265, SNP_A-2092973, SNP_A-2100843, SNP_A-1870760, SNP_A-1929756, SNP_A-2224458, SNP_A-1700353, SNP_A-1845608, SNP_A-1692103, SNP_A-1742688, SNP_A-1703549, SNP_A-1655443, SNP_A-1752123, SNP_A-1689046, SNP_A-1718064, SNP_A-1697744, SNP_A-1752193, SNP_A-1706392, SNP_A-1711735, SNP_A-1702729, SNP_A-1742263, SNP_A-1659290, SNP_A-1712691, SNP_A-1744013, SNP_A-1696646, SNP_A-1795031, SNP_A-1851177, SNP_A-1935474, SNP_A-2220624, SNP_A-1679946, SNP_A-2215216, SNP_A-4200283, SNP_A-2026522, SNP_A-4202310, SNP_A-2299484, SNP_A-1699453, SNP_A-1741393, SNP_A-1691438, SNP_A-2297092, SNP_A-1653604, SNP_A-1754998, SNP_A-1646440, SNP_A-1657251, SNP_A-1748950, SNP_A-1687377, SNP_A-1692553, SNP_A-4259028, SNP_A-2261657, SNP_A-1681124, SNP_A-1740913, SNP_A-1757507, SNP_A-1738709, SNP_A-1918147, SNP_A-1950140, SNP_A-2009621, SNP_A-1749078, SNP_A-2009660, SNP_A-1731927, SNP_A-1797657, SNP_A-1729559, SNP_A-1659084, SNP_A-1741686, SNP_A-1690765, SNP_A-1647892, SNP_A-1736862, SNP_A-1671313, SNP_A-1658373, SNP_A-1670587, SNP_A-1653923, SNP_A-1658987, SNP_A-1642350, SNP_A-1694620, SNP_A-1702162, SNP_A-1709072, SNP_A-1934790, SNP_A-2237762, SNP_A-1715170, SNP_A-1722617, SNP_A-2032090, SNP_A-1707022, SNP_A-1645089, SNP_A-1665341, SNP_A-1643853, SNP_A-2012607, SNP_A-2262626, SNP_A-2012637, SNP_A-1945210, SNP_A-1929283, SNP_A-4294891, SNP_A-2147347, SNP_A-4269830, SNP_A-2132446, SNP_A-2000050, SNP_A-2130913, SNP_A-2189026, SNP_A-4200188, SNP_A-1755845, SNP_A-2155380, SNP_A-1681555, SNP_A-1735714, SNP_A-2124612, SNP_A-1747588, SNP_A-1670090, SNP_A-1657356, SNP_A-1659125, SNP_A-1711289, SNP_A-1713573, SNP_A-4274072, SNP_A-2204193, SNP_A-1653229, SNP_A-1707120, SNP_A-1685111, SNP_A-4198459, SNP_A-1693838, SNP_A-4233965, SNP_A-2168928, SNP_A-1687655, SNP_A-1709030, SNP_A-1719830,

SNP_A-1847785, SNP_A-2014008, SNP_A-1682351, SNP_A-1685909, SNP_A-1676201, SNP_A-1732042, SNP_A-1737765, SNP_A-1740996, SNP_A-1905798, SNP_A-4258631, SNP_A-2312597, SNP_A-1715020, SNP_A-1756776, SNP_A-1695106, SNP_A-1747536, SNP_A-1680837, SNP_A-1731302, SNP_A-1678179, SNP_A-1729383, SNP_A-1659976, SNP_A-1668381, SNP_A-1714067, SNP_A-1661227, SNP_A-1666483, SNP_A-1692863, SNP_A-1739863, SNP_A-1671430, SNP_A-1742977, SNP_A-1704287, SNP_A-1663474, SNP_A-1727194, SNP_A-1729926, SNP_A-1682158, SNP_A-1656576, SNP_A-1680166, SNP_A-1643092, SNP_A-1693954, SNP_A-1709948, SNP_A-1653894, SNP_A-1723188, SNP_A-1690261, SNP_A-1758702, SNP_A-1718627, SNP_A-1690053, SNP_A-1657726, SNP_A-1673942, SNP_A-1643738, SNP_A-1727915, SNP_A-2120975, SNP_A-2188704, SNP_A-1878738, SNP_A-4221854, SNP_A-4207592, SNP_A-2156545, SNP_A-2087719, SNP_A-1892171, SNP_A-2119888, SNP_A-2088122, SNP_A-1881439, SNP_A-4260409, SNP_A-2094866, SNP_A-4257793, SNP_A-2144607, SNP_A-2095254, SNP_A-1722941, SNP_A-1731428, SNP_A-1667743, SNP_A-1652869, SNP_A-1705164, SNP_A-1653741, SNP_A-1658328, SNP_A-1694535, SNP_A-1644014, SNP_A-1656608, SNP_A-1651298, SNP_A-1732399, SNP_A-1657931, SNP_A-1645074, SNP_A-2109180, SNP_A-4281161, SNP_A-1901401, SNP_A-4281863, SNP_A-2138326, SNP_A-2231431, SNP_A-2111636, SNP_A-1835626, SNP_A-1718433, SNP_A-1750561, SNP_A-1730082, SNP_A-1747775, SNP_A-1752941, SNP_A-1755724, SNP_A-1649860, SNP_A-1675127, SNP_A-1700155, SNP_A-2136346, SNP_A-1894643, SNP_A-2089088, SNP_A-2282544, SNP_A-1866729, SNP_A-4291390, SNP_A-2178338, SNP_A-2311800, SNP_A-1949730, SNP_A-2158719, SNP_A-2168769, SNP_A-2198220, SNP_A-2060775, SNP_A-4198498, SNP_A-1652870, SNP_A-1753085, SNP_A-1688718, SNP_A-1673856, SNP_A-1647912, SNP_A-1717853, SNP_A-1899194, SNP_A-1786747, SNP_A-2144638, SNP_A-2277303, SNP_A-1744709, SNP_A-2121569, SNP_A-1651248, SNP_A-1688976, SNP_A-1674227, SNP_A-4233328, SNP_A-1724014, SNP_A-1668276, SNP_A-1732826, SNP_A-1730206, SNP_A-1736387, SNP_A-1664370, SNP_A-1671324, SNP_A-1668512, SNP_A-1730968, SNP_A-1736080, SNP_A-2290213,

SNP_A-1656108, SNP_A-1661012, SNP_A-4253798, SNP_A-4243053, SNP_A-1713272, SNP_A-4294121, SNP_A-2280976, SNP_A-2235561, SNP_A-1705619, SNP_A-1658714, SNP_A-1657443, SNP_A-1660037, SNP_A-1701423, SNP_A-1734912, SNP_A-1644962, SNP_A-1659756, SNP_A-1754063, SNP_A-1685178, SNP_A-1739341, SNP_A-1739893, SNP_A-4298222, SNP_A-2180125, SNP_A-4283318, SNP_A-1844477, SNP_A-1707738, SNP_A-1708870, SNP_A-1753896, SNP_A-1645039, SNP_A-1699076, SNP_A-1678935, SNP_A-1686149, SNP_A-1742040, SNP_A-1747286, SNP_A-1723905, SNP_A-1732390, SNP_A-1719466, SNP_A-1743968, SNP_A-2131045, SNP_A-2230640, SNP_A-1645207, SNP_A-1702498, SNP_A-1752942, SNP_A-1651183, SNP_A-1699904, SNP_A-1703572, SNP_A-1645511, SNP_A-1697876, SNP_A-1738105, SNP_A-1748132, SNP_A-1752288, SNP_A-1679719, SNP_A-1690134, SNP_A-1680601, SNP_A-1756220, SNP_A-1677078, SNP_A-1664920, SNP_A-1743158, SNP_A-1716141, SNP_A-1755447, SNP_A-1700664, SNP_A-1723092, SNP_A-1673357, SNP_A-1642277, SNP_A-1733149, SNP_A-1668778, SNP_A-1677865, SNP_A-1656358, SNP_A-2076585, SNP_A-1730239, SNP_A-1675050, SNP_A-1680439, SNP_A-1714794, SNP_A-1666233, SNP_A-1726261, SNP_A-2130990, SNP_A-2000195, SNP_A-4304476, SNP_A-2202858, SNP_A-1857771, SNP_A-2146348, SNP_A-1954668, SNP_A-4282356, SNP_A-2197613, SNP_A-2160729, SNP_A-1825054, SNP_A-4246668, SNP_A-1800772, SNP_A-1797786, SNP_A-4298188, SNP_A-4247398, SNP_A-4292326, SNP_A-4247469, SNP_A-1954356, SNP_A-1833666, SNP_A-4278274, SNP_A-1954511, SNP_A-2250378, SNP_A-1679197, SNP_A-2027544, SNP_A-1736878, SNP_A-1701538, SNP_A-1858176, SNP_A-2152127, SNP_A-2108706, SNP_A-2052826, SNP_A-4268074, SNP_A-1843390, SNP_A-4259881, SNP_A-1678313, SNP_A-1685397, SNP_A-1734093, SNP_A-1673701, SNP_A-1679079, SNP_A-4248590, SNP_A-2056345, SNP_A-2044041, SNP_A-1675216, SNP_A-1732907, SNP_A-1738586, SNP_A-1756361, SNP_A-1655990, SNP_A-1699162, SNP_A-1751548, SNP_A-1686331, SNP_A-1692951, SNP_A-1709077, SNP_A-1660863, SNP_A-1702151, SNP_A-1694042, SNP_A-1673538, SNP_A-1857766, SNP_A-1813635, SNP_A-1953075, SNP_A-1708050, SNP_A-1682368, SNP_A-1668030,

SNP_A-1754540, SNP_A-1707257, SNP_A-1757755, SNP_A-1687478, SNP_A-1949760, SNP_A-4205945, SNP_A-1921188, SNP_A-1950527, SNP_A-2255937, SNP_A-1888880, SNP_A-2136403, SNP_A-2100447, SNP_A-2209817, SNP_A-2044588, SNP_A-4216796, SNP_A-1892614, SNP_A-2000251, SNP_A-1710913, SNP_A-1645603, SNP_A-2273100, SNP_A-1642684, SNP_A-1691841, SNP_A-1652907, SNP_A-1661971, SNP_A-1706884, SNP_A-1652461, SNP_A-1704642, SNP_A-1755423, SNP_A-1648525, SNP_A-1643943, SNP_A-1689203, SNP_A-1654668, SNP_A-4198961, SNP_A-4233881, SNP_A-4217709, SNP_A-1751235, SNP_A-1653316, SNP_A-1655253, SNP_A-4257409, SNP_A-1924073, SNP_A-1838336, SNP_A-2263183, SNP_A-1783953, SNP_A-1888079, SNP_A-2128035, SNP_A-1932666, SNP_A-2227781, SNP_A-4293971, SNP_A-2255466, SNP_A-1709279, SNP_A-1657926, SNP_A-1703889, SNP_A-1663212, SNP_A-1650992, SNP_A-1733711, SNP_A-1662725, SNP_A-1664717, SNP_A-1713883, SNP_A-1655682, SNP_A-1648139, SNP_A-1676645, SNP_A-2220134, SNP_A-2226112, SNP_A-4292437, SNP_A-2083762, SNP_A-4242255, SNP_A-1863192, SNP_A-1648593, SNP_A-1702426, SNP_A-1696555, SNP_A-1735974, SNP_A-2194203, SNP_A-1962585, SNP_A-2191538, SNP_A-1873631, SNP_A-1962613, SNP_A-4298682, SNP_A-4257903, SNP_A-4206346, SNP_A-1962697, SNP_A-2216347, SNP_A-2165553, SNP_A-1876354, SNP_A-2046638, SNP_A-1715681, SNP_A-1687952, SNP_A-2229738, SNP_A-1673914, SNP_A-1725660, SNP_A-1716585, SNP_A-1719137, SNP_A-1664506, SNP_A-1949671, SNP_A-2267899, SNP_A-4203757, SNP_A-4261033, SNP_A-2255564, SNP_A-2303006, SNP_A-2050497, SNP_A-1688495, SNP_A-2089496, SNP_A-1708349, SNP_A-4195181, SNP_A-1645027, SNP_A-1652047, SNP_A-1964247, SNP_A-1711145, SNP_A-2206120, SNP_A-1802119, SNP_A-1649469, SNP_A-4273010, SNP_A-1870923, SNP_A-1686862, SNP_A-1755998, SNP_A-1699066, SNP_A-2273168, SNP_A-1701010, SNP_A-1959060, SNP_A-1711495, SNP_A-1928285, SNP_A-1748753, SNP_A-2030294, SNP_A-1695923, SNP_A-2026531, SNP_A-1692411, SNP_A-1730977, SNP_A-4281880, SNP_A-1687449, SNP_A-8525735, SNP_A-8534435, SNP_A-8657325, SNP_A-1940848, SNP_A-8298181, SNP_A-4238570, SNP_A-2150864, SNP_A-1684015,

SNP_A-2030917, SNP_A-4239468, SNP_A-1709371, SNP_A-4195473, SNP_A-4273324, SNP_A-1656538, SNP_A-1746809, SNP_A-1746967, SNP_A-1648386, SNP_A-1672630, SNP_A-1750441, SNP_A-1660339, SNP_A-1731656, SNP_A-1654623, SNP_A-1754563, SNP_A-1650693, SNP_A-8647704, SNP_A-8448712, SNP_A-1895400, SNP_A-8454210, SNP_A-1966041, SNP_A-1933213, SNP_A-2297422, SNP_A-1810661, SNP_A-8607368, SNP_A-8706696, SNP_A-8693205, SNP_A-1966410, SNP_A-8586568, SNP_A-1827567, SNP_A-2000354, SNP_A-8537289, SNP_A-8432668, SNP_A-8496440, SNP_A-8354055, SNP_A-2261531, SNP_A-1885870, SNP_A-2123011, SNP_A-1966534, SNP_A-2127936, SNP_A-2197541, SNP_A-1886660, SNP_A-2234086, SNP_A-1806941, SNP_A-2293305, SNP_A-2251617, SNP_A-4298215, SNP_A-2212321, SNP_A-1782105, SNP_A-2104960, SNP_A-8658765, SNP_A-8545494, SNP_A-8577429, SNP_A-2132898, SNP_A-8383343, SNP_A-2271973, SNP_A-4257979, SNP_A-8697360, SNP_A-8479314, SNP_A-8363245, SNP_A-8288815, SNP_A-8577917, SNP_A-8452601, SNP_A-2231086, SNP_A-1835677, SNP_A-2128246, SNP_A-8501801, SNP_A-2141975, SNP_A-8301895, SNP_A-2254479, SNP_A-8538251, SNP_A-2000368, SNP_A-2042485, SNP_A-2150361, SNP_A-2115525, SNP_A-1780893, SNP_A-1886171, SNP_A-1858247, SNP_A-1678992, SNP_A-1686546, SNP_A-1701209, SNP_A-1660255, SNP_A-1688018, SNP_A-2067390, SNP_A-2231975, SNP_A-4213944, SNP_A-4291882, SNP_A-1691779, SNP_A-1680263, SNP_A-1729757, SNP_A-1735059, SNP_A-1655528, SNP_A-1662331, SNP_A-1704148, SNP_A-4229977, SNP_A-4268105, SNP_A-1652430, SNP_A-1700787, SNP_A-1705023, SNP_A-1757887, SNP_A-1677810, SNP_A-1669645, SNP_A-1667278, SNP_A-4148259, SNP_A-1896029, SNP_A-1939568, SNP_A-2274238, SNP_A-1861176, SNP_A-1970666, SNP_A-4213949, SNP_A-2225920, SNP_A-1652699, SNP_A-1659495, SNP_A-2178738, SNP_A-1970740, SNP_A-1703148, SNP_A-4221873, SNP_A-1703730, SNP_A-1641910, SNP_A-1749720, SNP_A-1652759, SNP_A-1712148, SNP_A-1688317, SNP_A-1732276, SNP_A-1740888, SNP_A-1668695, SNP_A-1684238, SNP_A-1665254, SNP_A-1731945, SNP_A-1712325, SNP_A-1720023, SNP_A-1659128, SNP_A-1649495, SNP_A-1667413, SNP_A-1674396, SNP_A-1663175,

SNP_A-1675498, SNP_A-1713783, SNP_A-1660612, SNP_A-1664205, SNP_A-1713010, SNP_A-1658015, SNP_A-1705060, SNP_A-1645385, SNP_A-4257816, SNP_A-2309849, SNP_A-2172905, SNP_A-4243419, SNP_A-4286536, SNP_A-4256497, SNP_A-4254984, SNP_A-2130594, SNP_A-1756215, SNP_A-1703078, SNP_A-1743566, SNP_A-1687087, SNP_A-1691473, SNP_A-1693568, SNP_A-1705778, SNP_A-1756338, SNP_A-1684611, SNP_A-1698664, SNP_A-1743536, SNP_A-4249444, SNP_A-2309078, SNP_A-4254761, SNP_A-4247915, SNP_A-4245265, SNP_A-4245886, SNP_A-4302836, SNP_A-1662111, SNP_A-2000502, SNP_A-1745593, SNP_A-1756235, SNP_A-1691023, SNP_A-1677755, SNP_A-1733715, SNP_A-1724645, SNP_A-1664135, SNP_A-1751480, SNP_A-1723141, SNP_A-1731536, SNP_A-1662733, SNP_A-1663381, SNP_A-1686527, SNP_A-1681945, SNP_A-1732997, SNP_A-4194471, SNP_A-1662261, SNP_A-1667613, SNP_A-1716512, SNP_A-1708710, SNP_A-1702752, SNP_A-1644471, SNP_A-1686079, SNP_A-1694612, SNP_A-1696713, SNP_A-1976339, SNP_A-1643426, SNP_A-1702754, SNP_A-1746549, SNP_A-1691819, SNP_A-1710402, SNP_A-1723009, SNP_A-1734581, SNP_A-1745933, SNP_A-1715076, SNP_A-1725965, SNP_A-1716408, SNP_A-1650973, SNP_A-1748734, SNP_A-1754175, SNP_A-1665973, SNP_A-1645211, SNP_A-1695720, SNP_A-1701184, SNP_A-1754785, SNP_A-1644461, SNP_A-1737152, SNP_A-1743558, SNP_A-1661711, SNP_A-1719006, SNP_A-1661134, SNP_A-1978070, SNP_A-1955831, SNP_A-1694278, SNP_A-1744753, SNP_A-4264421, SNP_A-1834736, SNP_A-1676802, SNP_A-4246844, SNP_A-1806577, SNP_A-1731131, SNP_A-1751323, SNP_A-2237649, SNP_A-4243123, SNP_A-1978568, SNP_A-2225722, SNP_A-2030756, SNP_A-2114090, SNP_A-1786975, SNP_A-1690664, SNP_A-1697820, SNP_A-1739832, SNP_A-1686721, SNP_A-1702990, SNP_A-1750482, SNP_A-1745483, SNP_A-1752710, SNP_A-1717372, SNP_A-1725025, SNP_A-1745581, SNP_A-1756163, SNP_A-1734607, SNP_A-1932532, SNP_A-1744656, SNP_A-1676089, SNP_A-1679733, SNP_A-1735601, SNP_A-1664835, SNP_A-1673911, SNP_A-1713144, SNP_A-1699680, SNP_A-1740694, SNP_A-1667581, SNP_A-1722067, SNP_A-1663341, SNP_A-1740108, SNP_A-1680021, SNP_A-1690432, SNP_A-1656046, SNP_A-1681673,

SNP_A-1732689, SNP_A-1739464, SNP_A-1742590, SNP_A-2181500, SNP_A-1674097, SNP_A-1802871, SNP_A-8392252, SNP_A-1701633, SNP_A-1727055, SNP_A-2118555, SNP_A-1713477, SNP_A-1642993, SNP_A-1667362, SNP_A-1709895, SNP_A-2093242, SNP_A-1719353, SNP_A-8557339, SNP_A-1707749, SNP_A-1713195, SNP_A-1676308, SNP_A-2039942, SNP_A-4264765, SNP_A-2117900, SNP_A-4287786, SNP_A-1980957, SNP_A-4259031, SNP_A-1651787, SNP_A-2165339, SNP_A-1662031, SNP_A-2252512, SNP_A-2219866, SNP_A-4290355, SNP_A-1709512, SNP_A-1689224, SNP_A-2203419, SNP_A-1698148, SNP_A-2078017, SNP_A-1695449, SNP_A-2225453, SNP_A-2188960, SNP_A-1893051, SNP_A-1642764, SNP_A-2124212, SNP_A-1981071, SNP_A-2212684, SNP_A-4271296, SNP_A-2298986, SNP_A-1698640, SNP_A-1739028, SNP_A-1754368, SNP_A-1752794, SNP_A-1684372, SNP_A-1718287, SNP_A-1837584, SNP_A-4206789, SNP_A-2056231, SNP_A-1886311, SNP_A-1948181, SNP_A-1756238, SNP_A-1695480, SNP_A-1708304, SNP_A-1696412, SNP_A-1751358, SNP_A-1677425, SNP_A-1680887, SNP_A-1656827, SNP_A-1752459, SNP_A-1726105, SNP_A-1670519, SNP_A-1725019, SNP_A-1652307, SNP_A-1729858, SNP_A-1752197, SNP_A-1669375, SNP_A-1668504, SNP_A-1669419, SNP_A-2219058, SNP_A-2217774, SNP_A-4265092, SNP_A-2174865, SNP_A-1727706, SNP_A-1643885, SNP_A-1657847, SNP_A-1703298, SNP_A-1648209, SNP_A-1691911, SNP_A-1716838, SNP_A-1727718, SNP_A-1730940, SNP_A-1711025, SNP_A-1722039, SNP_A-1650733, SNP_A-1663129, SNP_A-1642918, SNP_A-1808458, SNP_A-1913335, SNP_A-1645515, SNP_A-1689515, SNP_A-4265148, SNP_A-1653903, SNP_A-1896705, SNP_A-1643937, SNP_A-1707094, SNP_A-1692233, SNP_A-1745713, SNP_A-4220891, SNP_A-1983393, SNP_A-1983714, SNP_A-4284153, SNP_A-2258999, SNP_A-1744808, SNP_A-1682793, SNP_A-1737356, SNP_A-1669886, SNP_A-1750462, SNP_A-1644803, SNP_A-1717952, SNP_A-1730844, SNP_A-1748402, SNP_A-1755225, SNP_A-1684627, SNP_A-1694912, SNP_A-1741986, SNP_A-4198927, SNP_A-1693968, SNP_A-1744102, SNP_A-1683205, SNP_A-1693668, SNP_A-1751206, SNP_A-1687589, SNP_A-1984562, SNP_A-2310305, SNP_A-1984587, SNP_A-1730260, SNP_A-1686436, SNP_A-1685610,

SNP_A-1738629, SNP_A-1692262, SNP_A-1647290, SNP_A-1697120, SNP_A-1679114, SNP_A-2213852, SNP_A-1701185, SNP_A-1744651, SNP_A-2117489, SNP_A-1654243, SNP_A-1985056, SNP_A-1663103, SNP_A-1714192, SNP_A-2166427, SNP_A-2125040, SNP_A-1721098, SNP_A-1653273, SNP_A-1647269, SNP_A-1874057, SNP_A-4237529, SNP_A-4218102, SNP_A-4216284, SNP_A-2259932, SNP_A-4192586, SNP_A-2224322, SNP_A-1696741, SNP_A-1700637, SNP_A-1658133, SNP_A-1661843, SNP_A-1705408, SNP_A-1721374, SNP_A-2092005, SNP_A-2127351, SNP_A-2171102, SNP_A-1821861, SNP_A-8556471, SNP_A-4245708, SNP_A-1881227, SNP_A-1690224, SNP_A-2000739, SNP_A-1670098, SNP_A-1679207, SNP_A-1722897, SNP_A-4223946, SNP_A-1651575, SNP_A-1676059, SNP_A-1732531, SNP_A-1670158, SNP_A-1660552, SNP_A-1718824, SNP_A-1662873, SNP_A-1657090, SNP_A-1712880, SNP_A-4284343, SNP_A-1987681, SNP_A-2286411, SNP_A-4224894, SNP_A-2290493, SNP_A-1857287, SNP_A-1988051, SNP_A-4205454, SNP_A-1829734, SNP_A-4226476, SNP_A-8443475, SNP_A-4193643, SNP_A-8387636, SNP_A-8290909, SNP_A-2024454, SNP_A-1722309, SNP_A-1725651, SNP_A-1665117, SNP_A-1728674, SNP_A-1659187, SNP_A-1887852, SNP_A-1646483, SNP_A-1700546, SNP_A-2073852, SNP_A-1643432, SNP_A-1685343, SNP_A-1743521, SNP_A-1681285, SNP_A-1684609, SNP_A-1642785, SNP_A-1990023, SNP_A-1647585, SNP_A-2243229, SNP_A-1704499, SNP_A-2061724, SNP_A-1680822, SNP_A-1990030, SNP_A-1651978, SNP_A-1645696, SNP_A-1678950, SNP_A-1670674, SNP_A-1642483, SNP_A-1733702, SNP_A-1740937, SNP_A-1668438, SNP_A-1676524, SNP_A-1658622, SNP_A-2247577, SNP_A-4281317, SNP_A-1653484, SNP_A-1720807, SNP_A-1716175, SNP_A-4299504, SNP_A-2133734, SNP_A-4296508, SNP_A-2096983, SNP_A-1903969, SNP_A-1805469, SNP_A-2199903, SNP_A-2305561, SNP_A-2295204, SNP_A-2000854, SNP_A-1954976, SNP_A-1810069, SNP_A-2136114, SNP_A-2107567, SNP_A-2171001, SNP_A-2069019, SNP_A-1787691, SNP_A-1808393, SNP_A-1816242, SNP_A-2091911, SNP_A-2155593, SNP_A-1934649, SNP_A-4279940, SNP_A-4286451, SNP_A-1746228, SNP_A-1730703, SNP_A-1838932, SNP_A-2137263, SNP_A-1991467, SNP_A-1783354, SNP_A-1746510,

SNP_A-2197362, SNP_A-8423663, SNP_A-1740417, SNP_A-1643641, SNP_A-1694939, SNP_A-1714213, SNP_A-1727959, SNP_A-1693290, SNP_A-1701080, SNP_A-1704404, SNP_A-1644399, SNP_A-1651773, SNP_A-1696726, SNP_A-1732496, SNP_A-2206572, SNP_A-1867982, SNP_A-1702412, SNP_A-1905524, SNP_A-1700861, SNP_A-8612771, SNP_A-8686718, SNP_A-4289125, SNP_A-2065319, SNP_A-2105213, SNP_A-4200262, SNP_A-4223408, SNP_A-8475206, SNP_A-1852536, SNP_A-1672296, SNP_A-2178141, SNP_A-1687456, SNP_A-1654446, SNP_A-1659331, SNP_A-1710204, SNP_A-1947396, SNP_A-4233330, SNP_A-2245231, SNP_A-2006081, SNP_A-4226179, SNP_A-1723914, SNP_A-4256057, SNP_A-1803954, SNP_A-1852491, SNP_A-2047816, SNP_A-8678676, SNP_A-8656924, SNP_A-1661361, SNP_A-1715716, SNP_A-1723261, SNP_A-1681893, SNP_A-1687161, SNP_A-1726693, SNP_A-2253519, SNP_A-4229178, SNP_A-1705312, SNP_A-1747222, SNP_A-1692325, SNP_A-1687939, SNP_A-1676475, SNP_A-1681823, SNP_A-1737937, SNP_A-1711525, SNP_A-1716606, SNP_A-1702254, SNP_A-1694774, SNP_A-1739926, SNP_A-1746906, SNP_A-1683423, SNP_A-1706152, SNP_A-1690688, SNP_A-1734321, SNP_A-1741282, SNP_A-1746007, SNP_A-1727015, SNP_A-1741942, SNP_A-1704780, SNP_A-1753496, SNP_A-1720419, SNP_A-1703465, SNP_A-1750249, SNP_A-1661562, SNP_A-1700600, SNP_A-1700498, SNP_A-1727533, SNP_A-1746341, SNP_A-1715575, SNP_A-1675979, SNP_A-1678080, SNP_A-1730462, SNP_A-1739661, SNP_A-1688114, SNP_A-1663662, SNP_A-1720569, SNP_A-1725901, SNP_A-1745344, SNP_A-1670725, SNP_A-1712956, SNP_A-1721853, SNP_A-1717876, SNP_A-1733549, SNP_A-1720246, SNP_A-1672115, SNP_A-1714321, SNP_A-4223551, SNP_A-1654246, SNP_A-8538750, SNP_A-1704548, SNP_A-1652877, SNP_A-1750314, SNP_A-1647429, SNP_A-1668355, SNP_A-2286020, SNP_A-2146127, SNP_A-1671516, SNP_A-2202577, SNP_A-1740723, SNP_A-4207944, SNP_A-1714451, SNP_A-1738841, SNP_A-2257569, SNP_A-1682836, SNP_A-1962409, SNP_A-1652899, SNP_A-1661961, SNP_A-1706998, SNP_A-1693742, SNP_A-1699524, SNP_A-1665501, SNP_A-2308103, SNP_A-1721877, SNP_A-1659567, SNP_A-1704656, SNP_A-2138234, SNP_A-8627781, SNP_A-1654686, SNP_A-1703612,

SNP_A-1652371, SNP_A-1687807, SNP_A-1692881, SNP_A-1698672, SNP_A-1702070, SNP_A-1753326, SNP_A-1741816, SNP_A-1703192, SNP_A-1648343, SNP_A-1751070, SNP_A-1679279, SNP_A-1738842, SNP_A-1689685, SNP_A-1698667, SNP_A-1643003, SNP_A-1651798, SNP_A-2312250, SNP_A-1745739, SNP_A-1647968, SNP_A-1727411, SNP_A-1741618, SNP_A-2087248, SNP_A-1799010, SNP_A-2006240, SNP_A-2118044, SNP_A-1877841, SNP_A-2240912, SNP_A-1680065, SNP_A-2237310, SNP_A-1950443, SNP_A-1670002, SNP_A-2221970, SNP_A-1741022, SNP_A-1749822, SNP_A-1751768, SNP_A-1682975, SNP_A-1689599, SNP_A-1667993, SNP_A-1731064, SNP_A-1658351, SNP_A-1670839, SNP_A-1715904, SNP_A-1721785, SNP_A-1725505, SNP_A-1659315, SNP_A-1736728, SNP_A-2224921, SNP_A-1679909, SNP_A-1726637, SNP_A-1664317, SNP_A-1711655, SNP_A-1710587, SNP_A-1643653, SNP_A-1652353, SNP_A-1669877, SNP_A-1656051, SNP_A-1698643, SNP_A-1699679, SNP_A-1676960, SNP_A-1661139, SNP_A-1661041, SNP_A-1756883, SNP_A-1673338, SNP_A-1748441, SNP_A-1846619, SNP_A-2285638, SNP_A-1664330, SNP_A-1956840, SNP_A-1853072, SNP_A-2141464, SNP_A-4231570, SNP_A-2006280, SNP_A-4199489, SNP_A-1686581, SNP_A-1697375, SNP_A-1742454, SNP_A-1751464, SNP_A-1651807, SNP_A-1709288, SNP_A-1717804, SNP_A-1645645, SNP_A-1642658, SNP_A-1682083, SNP_A-1692263, SNP_A-1748074, SNP_A-1701958, SNP_A-1752430, SNP_A-1746547, SNP_A-1740902, SNP_A-1690144, SNP_A-1673175, SNP_A-1683683, SNP_A-1734827, SNP_A-8430570, SNP_A-8572867, SNP_A-2143602, SNP_A-2095357, SNP_A-4208034, SNP_A-1661570, SNP_A-1819309, SNP_A-2046915, SNP_A-2234273, SNP_A-1694996, SNP_A-1742177, SNP_A-1706144, SNP_A-1683323, SNP_A-1690204, SNP_A-1739068, SNP_A-1682339, SNP_A-1962999, SNP_A-1849209, SNP_A-1660716, SNP_A-1644277, SNP_A-1691607, SNP_A-1755741, SNP_A-1712158, SNP_A-1658887, SNP_A-2130369, SNP_A-1798288, SNP_A-2223600, SNP_A-1786665, SNP_A-1740803, SNP_A-1662812, SNP_A-1725170, SNP_A-1690167, SNP_A-1696172, SNP_A-1690996, SNP_A-1697983, SNP_A-1712136, SNP_A-1715772, SNP_A-1723133, SNP_A-1705884, SNP_A-1714886, SNP_A-1680649, SNP_A-1694772, SNP_A-1672815,

SNP_A-1676782, SNP_A-1719243, SNP_A-1740451, SNP_A-1721127, SNP_A-1677116, SNP_A-1696374, SNP_A-1664422, SNP_A-1729186, SNP_A-1710600, SNP_A-1662701, SNP_A-1706560, SNP_A-1655210, SNP_A-1700495, SNP_A-1641848, SNP_A-1703372, SNP_A-1719586, SNP_A-1650917, SNP_A-1659974, SNP_A-1708842, SNP_A-1691995, SNP_A-1747860, SNP_A-1644351, SNP_A-1644837, SNP_A-1648269, SNP_A-1704006, SNP_A-1707845, SNP_A-1687489, SNP_A-1692981, SNP_A-1698410, SNP_A-1753462, SNP_A-1735137, SNP_A-1679761, SNP_A-1717626, SNP_A-1728376, SNP_A-1747130, SNP_A-1755969, SNP_A-1685543, SNP_A-1690818, SNP_A-8383306, SNP_A-1742506, SNP_A-4240418, SNP_A-1674025, SNP_A-1963532, SNP_A-1939090, SNP_A-2185952, SNP_A-4282841, SNP_A-1855024, SNP_A-2175394, SNP_A-1721286, SNP_A-1656856, SNP_A-2290075, SNP_A-1680091, SNP_A-1740758, SNP_A-1744520, SNP_A-1678883, SNP_A-1733285, SNP_A-1664251, SNP_A-1672899, SNP_A-1730814, SNP_A-1641758, SNP_A-1647287, SNP_A-1666585, SNP_A-1723109, SNP_A-1728342, SNP_A-1667747, SNP_A-1716528, SNP_A-1860555, SNP_A-1963628, SNP_A-1750140, SNP_A-1642518, SNP_A-1684825, SNP_A-1740826, SNP_A-1666815, SNP_A-1714271, SNP_A-2170974, SNP_A-8296057, SNP_A-8392479, SNP_A-2006459, SNP_A-1963696, SNP_A-1963762, SNP_A-8535650, SNP_A-2038405, SNP_A-8680380, SNP_A-8680010, SNP_A-2116367, SNP_A-8692709, SNP_A-8687775, SNP_A-4269001, SNP_A-8332952, SNP_A-8330304, SNP_A-8470351, SNP_A-1942930, SNP_A-1963806, SNP_A-1724209, SNP_A-1654888, SNP_A-1662143, SNP_A-1665661, SNP_A-1753294, SNP_A-1691145, SNP_A-1738636, SNP_A-1672837, SNP_A-1722573, SNP_A-1734269, SNP_A-1667061, SNP_A-1721543, SNP_A-1652173, SNP_A-1717154, SNP_A-8509335, SNP_A-1707989, SNP_A-1644393, SNP_A-1693195, SNP_A-1680169, SNP_A-4259088, SNP_A-1744532, SNP_A-1749872, SNP_A-1681297, SNP_A-1868001, SNP_A-1740628, SNP_A-1683595, SNP_A-1729499, SNP_A-1672417, SNP_A-1725465, SNP_A-1730668, SNP_A-1661553, SNP_A-1672881, SNP_A-1736714, SNP_A-1756685, SNP_A-1745109, SNP_A-1717099, SNP_A-1734218, SNP_A-1642213, SNP_A-2060297, SNP_A-2035064, SNP_A-2076764, SNP_A-1964170, SNP_A-2268044,

SNP_A-1905825, SNP_A-4198857, SNP_A-2241614, SNP_A-2230135, SNP_A-1656673, SNP_A-2189269, SNP_A-2297248, SNP_A-4233836, SNP_A-4298862, SNP_A-2181489, SNP_A-2139762, SNP_A-2051223, SNP_A-2106372, SNP_A-2292639, SNP_A-2299279, SNP_A-1685913, SNP_A-1693047, SNP_A-1711122, SNP_A-1705118, SNP_A-1654251, SNP_A-1656407, SNP_A-1698895, SNP_A-1728457, SNP_A-2072410, SNP_A-2111424, SNP_A-4208267, SNP_A-1964319, SNP_A-4249959, SNP_A-1690504, SNP_A-1685937, SNP_A-1691061, SNP_A-1698394, SNP_A-1732621, SNP_A-1742362, SNP_A-1722239, SNP_A-1651263, SNP_A-1654768, SNP_A-1747600, SNP_A-1642388, SNP_A-1744806, SNP_A-1752408, SNP_A-1690184, SNP_A-1709888, SNP_A-8700617, SNP_A-8531724, SNP_A-4294470, SNP_A-2006605, SNP_A-8557769, SNP_A-2039178, SNP_A-2205163, SNP_A-8528923, SNP_A-2313759, SNP_A-4278248, SNP_A-2184292, SNP_A-8690418, SNP_A-8688491, SNP_A-8390787, SNP_A-8525651, SNP_A-4232860, SNP_A-1712161, SNP_A-1718935, SNP_A-1660279, SNP_A-1758983, SNP_A-1646702, SNP_A-1723668, SNP_A-1755792, SNP_A-8328397, SNP_A-8496797, SNP_A-8656136, SNP_A-4291317, SNP_A-2036441, SNP_A-8303974, SNP_A-1683469, SNP_A-1665087, SNP_A-1671999, SNP_A-1713200, SNP_A-1716914, SNP_A-1757144, SNP_A-1746504, SNP_A-1738250, SNP_A-1745752, SNP_A-1670706, SNP_A-1704253, SNP_A-1694857, SNP_A-1731519, SNP_A-1707619, SNP_A-1735013, SNP_A-1747414, SNP_A-1650783, SNP_A-8358465, SNP_A-1711908, SNP_A-1964966, SNP_A-1840279, SNP_A-2070746, SNP_A-8495133, SNP_A-1923122, SNP_A-1965097, SNP_A-2309841, SNP_A-2197368, SNP_A-1898229, SNP_A-2217700, SNP_A-2292482, SNP_A-8563389, SNP_A-1965153, SNP_A-2296061, SNP_A-1731123, SNP_A-1658506, SNP_A-8587498, SNP_A-1743041, SNP_A-1699841, SNP_A-1669159, SNP_A-1658966, SNP_A-1690637, SNP_A-1649838, SNP_A-2246252, SNP_A-2229491, SNP_A-1855088, SNP_A-1808044, SNP_A-4250615, SNP_A-4207299, SNP_A-8675647, SNP_A-2006780, SNP_A-8562682, SNP_A-8711650, SNP_A-1888459, SNP_A-1965456, SNP_A-4198574, SNP_A-1829553, SNP_A-1658433, SNP_A-1667469, SNP_A-1737340, SNP_A-1675691, SNP_A-1673057, SNP_A-1678863, SNP_A-1680625, SNP_A-1733221,

SNP_A-4214613, SNP_A-2158064, SNP_A-1719644, SNP_A-1645369, SNP_A-1650599, SNP_A-1699454, SNP_A-1713333, SNP_A-1642706, SNP_A-1646381, SNP_A-1745813, SNP_A-2272588, SNP_A-4192979, SNP_A-2226302, SNP_A-1708063, SNP_A-1647915, SNP_A-1693458, SNP_A-1742306, SNP_A-1680367, SNP_A-1664765, SNP_A-1722471, SNP_A-1750390, SNP_A-1755647, SNP_A-1935556, SNP_A-1691809, SNP_A-1965696, SNP_A-1859881, SNP_A-1732222, SNP_A-1843497, SNP_A-1745881, SNP_A-1670555, SNP_A-1677297, SNP_A-1656096, SNP_A-1708245, SNP_A-1712118, SNP_A-1714019, SNP_A-1718980, SNP_A-1657432, SNP_A-1681564, SNP_A-1681590, SNP_A-1642087, SNP_A-1753353, SNP_A-1825366, SNP_A-2022566, SNP_A-1928312, SNP_A-4230842, SNP_A-1748922, SNP_A-1752738, SNP_A-1647279, SNP_A-1697806, SNP_A-1701766, SNP_A-1745062, SNP_A-1689986, SNP_A-2157052, SNP_A-1820355, SNP_A-1862814, SNP_A-1673141, SNP_A-1687103, SNP_A-1736010, SNP_A-1719382, SNP_A-1728542, SNP_A-1661192, SNP_A-1743226, SNP_A-1672693, SNP_A-1727249, SNP_A-1663251, SNP_A-1670318, SNP_A-1725005, SNP_A-1659087, SNP_A-1711571, SNP_A-1718520, SNP_A-1682837, SNP_A-1686383, SNP_A-1739002, SNP_A-1730836, SNP_A-1731100, SNP_A-1661887, SNP_A-1745307, SNP_A-1680105, SNP_A-1742768, SNP_A-1668972, SNP_A-1719564, SNP_A-1727017, SNP_A-1733635, SNP_A-1669892, SNP_A-1642540, SNP_A-1698104, SNP_A-1752198, SNP_A-1757742, SNP_A-1659787, SNP_A-1717192, SNP_A-1657078, SNP_A-1665985, SNP_A-1713066, SNP_A-1647839, SNP_A-1749738, SNP_A-1674982, SNP_A-1680347, SNP_A-1966140, SNP_A-1687355, SNP_A-2186661, SNP_A-1734815, SNP_A-1741640, SNP_A-1672779, SNP_A-1727137, SNP_A-1681649, SNP_A-1691925, SNP_A-2243812, SNP_A-2225800, SNP_A-1750052, SNP_A-1901448, SNP_A-1672513, SNP_A-1684665, SNP_A-1728538, SNP_A-1739064, SNP_A-1731305, SNP_A-1707275, SNP_A-1688892, SNP_A-1668805, SNP_A-2106711, SNP_A-4232664, SNP_A-1649442, SNP_A-1715505, SNP_A-1651866, SNP_A-1653650, SNP_A-1688794, SNP_A-1657425, SNP_A-1701067, SNP_A-1697819, SNP_A-1653166, SNP_A-1646292, SNP_A-1654885, SNP_A-1659640, SNP_A-1656537, SNP_A-1724531, SNP_A-1667365, SNP_A-1725423,

SNP_A-1651229, SNP_A-1654800, SNP_A-1703274, SNP_A-1705282, SNP_A-2198004, SNP_A-2172064, SNP_A-1881185, SNP_A-1919864, SNP_A-2024775, SNP_A-4248053, SNP_A-1842862, SNP_A-2181061, SNP_A-2114716, SNP_A-2222564, SNP_A-1874361, SNP_A-1834909, SNP_A-1966327, SNP_A-4208579, SNP_A-1846522, SNP_A-1833768, SNP_A-1842674, SNP_A-4233043, SNP_A-1858844, SNP_A-2255162, SNP_A-1683445, SNP_A-1691695, SNP_A-1733813, SNP_A-1742776, SNP_A-1655318, SNP_A-1712700, SNP_A-2072285, SNP_A-1821497, SNP_A-2128287, SNP_A-2006944, SNP_A-1671569, SNP_A-1715584, SNP_A-1651981, SNP_A-1658445, SNP_A-1736962, SNP_A-1664411, SNP_A-1730981, SNP_A-1705307, SNP_A-1668616, SNP_A-1673692, SNP_A-1706641, SNP_A-1666678, SNP_A-1644118, SNP_A-1703208, SNP_A-1756942, SNP_A-1664597, SNP_A-1674640, SNP_A-1716664, SNP_A-1747381, SNP_A-1696716, SNP_A-1645084, SNP_A-1708096, SNP_A-1682232, SNP_A-1675419, SNP_A-1675227, SNP_A-1697100, SNP_A-1700077, SNP_A-1658630, SNP_A-1654721, SNP_A-1710293, SNP_A-1739513, SNP_A-1712759, SNP_A-1806288, SNP_A-1956683, SNP_A-4208639, SNP_A-2299082, SNP_A-1758596, SNP_A-1717827, SNP_A-1727096, SNP_A-1646632, SNP_A-2313693, SNP_A-1966670, SNP_A-1953021, SNP_A-2208938, SNP_A-1717798, SNP_A-1723511, SNP_A-1747264, SNP_A-1756205, SNP_A-1687563, SNP_A-1696193, SNP_A-1695932, SNP_A-1724519, SNP_A-1729825, SNP_A-1733301, SNP_A-1720498, SNP_A-1661875, SNP_A-1681262, SNP_A-1685142, SNP_A-1699049, SNP_A-1708458, SNP_A-1815589, SNP_A-1812790, SNP_A-2230971, SNP_A-1816885, SNP_A-8508933, SNP_A-1725592, SNP_A-1700849, SNP_A-1753955, SNP_A-1758557, SNP_A-4281494, SNP_A-1754299, SNP_A-1673267, SNP_A-1719072, SNP_A-1658681, SNP_A-1672853, SNP_A-1727039, SNP_A-1703036, SNP_A-1713823, SNP_A-1695224, SNP_A-1710931, SNP_A-4304691, SNP_A-1821913, SNP_A-1700598, SNP_A-1756264, SNP_A-1690769, SNP_A-1750867, SNP_A-1752579, SNP_A-1677994, SNP_A-1707533, SNP_A-1646706, SNP_A-1649632, SNP_A-4262589, SNP_A-8315839, SNP_A-1828193, SNP_A-1831595, SNP_A-4277932, SNP_A-1677775, SNP_A-1679399, SNP_A-1681717, SNP_A-1685471, SNP_A-1739654, SNP_A-1744294,

SNP_A-1754749, SNP_A-2060530, SNP_A-1795096, SNP_A-2182741, SNP_A-1719458, SNP_A-1726335, SNP_A-1652023, SNP_A-1657501, SNP_A-1680503, SNP_A-1669126, SNP_A-1681671, SNP_A-1725709, SNP_A-1739186, SNP_A-1677011, SNP_A-1719016, SNP_A-1660604, SNP_A-1711125, SNP_A-1667893, SNP_A-1671731, SNP_A-1713427, SNP_A-1722607, SNP_A-1665555, SNP_A-1647139, SNP_A-1751438, SNP_A-1756862, SNP_A-1665326, SNP_A-1739031, SNP_A-1681562, SNP_A-1689184, SNP_A-1732438, SNP_A-1672173, SNP_A-1728532, SNP_A-1731502, SNP_A-1655524, SNP_A-1664045, SNP_A-1720280, SNP_A-1725879, SNP_A-1706796, SNP_A-1708726, SNP_A-1788671, SNP_A-2306918, SNP_A-4298782, SNP_A-4300949, SNP_A-1897402, SNP_A-8329508, SNP_A-4301020, SNP_A-4294672, SNP_A-2101733, SNP_A-2075635, SNP_A-2007107, SNP_A-8576840, SNP_A-1697170, SNP_A-1749600, SNP_A-1657248, SNP_A-1758238, SNP_A-1650965, SNP_A-1692667, SNP_A-1734878, SNP_A-1646759, SNP_A-4223701, SNP_A-1734887, SNP_A-1683036, SNP_A-1742824, SNP_A-1668873, SNP_A-1688398, SNP_A-1672343, SNP_A-1682955, SNP_A-8638036, SNP_A-1665344, SNP_A-1709406, SNP_A-1668757, SNP_A-1642069, SNP_A-1718535, SNP_A-1647472, SNP_A-1758503, SNP_A-1681506, SNP_A-1675440, SNP_A-1738177, SNP_A-1679783, SNP_A-8628746, SNP_A-2294252, SNP_A-4303109, SNP_A-1743250, SNP_A-1677650, SNP_A-1754047, SNP_A-1648538, SNP_A-1677230, SNP_A-1795341, SNP_A-1725653, SNP_A-1682533, SNP_A-2123486, SNP_A-2218387, SNP_A-2272612, SNP_A-4292663, SNP_A-1675458, SNP_A-2137704, SNP_A-4290164, SNP_A-1911062, SNP_A-1867689, SNP_A-2160826, SNP_A-8303109, SNP_A-2100278, SNP_A-4207196, SNP_A-2217596, SNP_A-2256007, SNP_A-4246219, SNP_A-2299260, SNP_A-2284824, SNP_A-2008366, SNP_A-1829511, SNP_A-2093487, SNP_A-4263284, SNP_A-1816749, SNP_A-4209249, SNP_A-4194302, SNP_A-2118731, SNP_A-1971388, SNP_A-8489070, SNP_A-2069556, SNP_A-2040964, SNP_A-1816095, SNP_A-4289813, SNP_A-1971445, SNP_A-1971452, SNP_A-1816864, SNP_A-1697774, SNP_A-1746650, SNP_A-1690306, SNP_A-1739022, SNP_A-1883382, SNP_A-4254118, SNP_A-4209275, SNP_A-2206442, SNP_A-2247453, SNP_A-1675208, SNP_A-1733021,

SNP_A-1662297, SNP_A-1682545, SNP_A-1746900, SNP_A-1723949, SNP_A-1832801, SNP_A-2292774, SNP_A-2136285, SNP_A-4256752, SNP_A-1714640, SNP_A-1647543, SNP_A-1750154, SNP_A-1788701, SNP_A-1693253, SNP_A-1718606, SNP_A-1661739, SNP_A-4230147, SNP_A-4214768, SNP_A-1911202, SNP_A-2237905, SNP_A-1792301, SNP_A-2253502, SNP_A-2190710, SNP_A-1829086, SNP_A-1912837, SNP_A-1971775, SNP_A-8363814, SNP_A-2148429, SNP_A-4243334, SNP_A-2218332, SNP_A-2107133, SNP_A-1726965, SNP_A-1839137, SNP_A-4252592, SNP_A-1897953, SNP_A-1866678, SNP_A-1718948, SNP_A-1727992, SNP_A-1655300, SNP_A-1675511, SNP_A-2129226, SNP_A-1679068, SNP_A-1655597, SNP_A-1650907, SNP_A-1641781, SNP_A-1670389, SNP_A-1713467, SNP_A-1671105, SNP_A-1678181, SNP_A-1740391, SNP_A-4204947, SNP_A-1671554, SNP_A-1721587, SNP_A-1657581, SNP_A-1713236, SNP_A-2086034, SNP_A-1824099, SNP_A-2086232, SNP_A-1800983, SNP_A-4281351, SNP_A-1862344, SNP_A-2134686, SNP_A-2282826, SNP_A-2229211, SNP_A-2113546, SNP_A-1971912, SNP_A-1971913, SNP_A-1971939, SNP_A-8707756, SNP_A-8474678, SNP_A-1925460, SNP_A-8377447, SNP_A-1972123, SNP_A-2041317, SNP_A-1972149, SNP_A-1972151, SNP_A-1960713, SNP_A-4254070, SNP_A-4294595, SNP_A-1660979, SNP_A-1645744, SNP_A-1662336, SNP_A-1743101, SNP_A-1699989, SNP_A-1717011, SNP_A-1745061, SNP_A-1746675, SNP_A-1865593, SNP_A-1896706, SNP_A-2211181, SNP_A-1972283, SNP_A-2137748, SNP_A-2228987, SNP_A-2119526, SNP_A-4274758, SNP_A-4285506, SNP_A-1972302, SNP_A-2256135, SNP_A-2055225, SNP_A-2281653, SNP_A-2008600, SNP_A-2293639, SNP_A-1886363, SNP_A-4222460, SNP_A-2284847, SNP_A-2119406, SNP_A-1871800, SNP_A-8362847, SNP_A-1842944, SNP_A-8464494, SNP_A-1888645, SNP_A-1783421, SNP_A-2068403, SNP_A-1659164, SNP_A-1757797, SNP_A-1703084, SNP_A-1683370, SNP_A-1665912, SNP_A-1725330, SNP_A-1756288, SNP_A-1697227, SNP_A-1716474, SNP_A-1724341, SNP_A-1707312, SNP_A-1643478, SNP_A-1699128, SNP_A-1740240, SNP_A-1680539, SNP_A-1685675, SNP_A-1746674, SNP_A-1682979, SNP_A-1746076, SNP_A-1653404, SNP_A-1659365, SNP_A-1666546, SNP_A-1652394, SNP_A-1649820,

SNP_A-1757529, SNP_A-1664494, SNP_A-1955211, SNP_A-8303531, SNP_A-8571690, SNP_A-2044635, SNP_A-8300665, SNP_A-4237626, SNP_A-8506292, SNP_A-2008658, SNP_A-8584270, SNP_A-2236999, SNP_A-4209429, SNP_A-1677291, SNP_A-1722715, SNP_A-1729893, SNP_A-1751038, SNP_A-1692333, SNP_A-1701008, SNP_A-1733925, SNP_A-1738814, SNP_A-4276872, SNP_A-1743698, SNP_A-1678691, SNP_A-2280133, SNP_A-2308206, SNP_A-1845673, SNP_A-1669032, SNP_A-1673129, SNP_A-1718452, SNP_A-2008664, SNP_A-1732579, SNP_A-2264826, SNP_A-2177660, SNP_A-8385010, SNP_A-4263497, SNP_A-4251350, SNP_A-8380797, SNP_A-8598267, SNP_A-2008680, SNP_A-1972637, SNP_A-1858874, SNP_A-1799208, SNP_A-1697215, SNP_A-1705272, SNP_A-1689355, SNP_A-1696899, SNP_A-1740566, SNP_A-1744028, SNP_A-1686131, SNP_A-1905818, SNP_A-2222080, SNP_A-1703525, SNP_A-1665816, SNP_A-1715983, SNP_A-1838656, SNP_A-4237759, SNP_A-1755080, SNP_A-1714669, SNP_A-1710782, SNP_A-1695241, SNP_A-1950320, SNP_A-2291973, SNP_A-1972896, SNP_A-1972912, SNP_A-2088752, SNP_A-1959809, SNP_A-2008761, SNP_A-1697471, SNP_A-1751624, SNP_A-1733421, SNP_A-1673187, SNP_A-1727778, SNP_A-1648321, SNP_A-1696863, SNP_A-1750802, SNP_A-2202851, SNP_A-4238907, SNP_A-1867267, SNP_A-2040697, SNP_A-1960341, SNP_A-2282002, SNP_A-4225714, SNP_A-1944283, SNP_A-4209540, SNP_A-1953843, SNP_A-1665192, SNP_A-1730010, SNP_A-1752585, SNP_A-1671330, SNP_A-2008844, SNP_A-2033577, SNP_A-1801903, SNP_A-2122060, SNP_A-1920456, SNP_A-2213721, SNP_A-2171521, SNP_A-4199414, SNP_A-1655121, SNP_A-1733158, SNP_A-1745530, SNP_A-1736497, SNP_A-2049125, SNP_A-2156023, SNP_A-2126685, SNP_A-2189820, SNP_A-2163208, SNP_A-2144499, SNP_A-2093564, SNP_A-4221366, SNP_A-4263621, SNP_A-1662845, SNP_A-1746205, SNP_A-2230694, SNP_A-1720793, SNP_A-2287110, SNP_A-8618619, SNP_A-1753511, SNP_A-8618620, SNP_A-1652318, SNP_A-2238104, SNP_A-1756301, SNP_A-2288929, SNP_A-2021535, SNP_A-1649341, SNP_A-2054161, SNP_A-1726912, SNP_A-1655477, SNP_A-1715495, SNP_A-1653282, SNP_A-1718106, SNP_A-1670034, SNP_A-1973558, SNP_A-4227993, SNP_A-2136270, SNP_A-4200070,

SNP_A-2203719, SNP_A-1650215, SNP_A-1651398, SNP_A-1675371, SNP_A-2262362, SNP_A-1799613, SNP_A-2233658, SNP_A-1719263, SNP_A-1732415, SNP_A-1738885, SNP_A-1697835, SNP_A-1688940, SNP_A-1708779, SNP_A-1758675, SNP_A-8460096, SNP_A-8660508, SNP_A-8334211, SNP_A-8595675, SNP_A-1715245, SNP_A-1726290, SNP_A-1642111, SNP_A-1672920, SNP_A-1731567, SNP_A-1729822, SNP_A-4216804, SNP_A-1672524, SNP_A-1654201, SNP_A-1794211, SNP_A-2194634, SNP_A-1803518, SNP_A-1674885, SNP_A-4242513, SNP_A-1745150, SNP_A-1973608, SNP_A-2103179, SNP_A-4245553, SNP_A-1949225, SNP_A-1973612, SNP_A-2126515, SNP_A-1698914, SNP_A-1709462, SNP_A-1643841, SNP_A-2137826, SNP_A-4209600, SNP_A-1689551, SNP_A-4257909, SNP_A-2116418, SNP_A-1973664, SNP_A-8353920, SNP_A-2127502, SNP_A-8505636, SNP_A-2285598, SNP_A-4232989, SNP_A-1961320, SNP_A-1845905, SNP_A-1664787, SNP_A-1665031, SNP_A-1741878, SNP_A-1743434, SNP_A-2270850, SNP_A-1674814, SNP_A-1734241, SNP_A-1668998, SNP_A-8487805, SNP_A-1677819, SNP_A-4214827, SNP_A-1973767, SNP_A-1948752, SNP_A-4209630, SNP_A-2048796, SNP_A-1955227, SNP_A-2135164, SNP_A-1918621, SNP_A-1973814, SNP_A-1973816, SNP_A-2128145, SNP_A-1973835, SNP_A-1941475, SNP_A-2079038, SNP_A-2136824, SNP_A-4232080, SNP_A-2311600, SNP_A-1681190, SNP_A-1739121, SNP_A-1705511, SNP_A-1712877, SNP_A-1687678, SNP_A-1680824, SNP_A-2108085, SNP_A-1889673, SNP_A-1827901, SNP_A-1973977, SNP_A-4224620, SNP_A-2307283, SNP_A-1666583, SNP_A-1738077, SNP_A-1742958, SNP_A-1737512, SNP_A-2266788, SNP_A-4240934, SNP_A-2123303, SNP_A-1973998, SNP_A-1677265, SNP_A-1723225, SNP_A-1728142, SNP_A-1974032, SNP_A-2027554, SNP_A-1835562, SNP_A-4217501, SNP_A-1974041, SNP_A-2175205, SNP_A-4252656, SNP_A-4291199, SNP_A-2099130, SNP_A-8619949, SNP_A-2087832, SNP_A-2181459, SNP_A-2171795, SNP_A-2043473, SNP_A-2166086, SNP_A-8696746, SNP_A-1675663, SNP_A-1703480, SNP_A-1754008, SNP_A-1643232, SNP_A-1974179, SNP_A-1682511, SNP_A-1693007, SNP_A-1742038, SNP_A-1687259, SNP_A-1974211, SNP_A-1675057, SNP_A-1689040, SNP_A-1707816, SNP_A-1733304, SNP_A-1679566,

SNP_A-1718277, SNP_A-1660495, SNP_A-2081232, SNP_A-4240599, SNP_A-2096770, SNP_A-1947157, SNP_A-1946972, SNP_A-4220619, SNP_A-1735698, SNP_A-1740900, SNP_A-1665723, SNP_A-1672875, SNP_A-1710234, SNP_A-1721272, SNP_A-1650397, SNP_A-4304718, SNP_A-8678910, SNP_A-8641220, SNP_A-1974297, SNP_A-1852945, SNP_A-2213819, SNP_A-2177508, SNP_A-2208536, SNP_A-1854255, SNP_A-2225347, SNP_A-2071322, SNP_A-4240867, SNP_A-2245553, SNP_A-1940376, SNP_A-1888066, SNP_A-1904939, SNP_A-1657490, SNP_A-1731439, SNP_A-1749959, SNP_A-1706203, SNP_A-1721812, SNP_A-1696384, SNP_A-1667682, SNP_A-1747389, SNP_A-1672794, SNP_A-1706113, SNP_A-1877855, SNP_A-2102991, SNP_A-1653403, SNP_A-1747270, SNP_A-1752684, SNP_A-1683893, SNP_A-1740142, SNP_A-1692922, SNP_A-1677560, SNP_A-1658658, SNP_A-1692418, SNP_A-1663672, SNP_A-1661496, SNP_A-2122961, SNP_A-1904868, SNP_A-2268796, SNP_A-2122695, SNP_A-1913358, SNP_A-2077016, SNP_A-4196276, SNP_A-2009150, SNP_A-2052561, SNP_A-1792360, SNP_A-4234853, SNP_A-2121803, SNP_A-4292254, SNP_A-4269384, SNP_A-4249113, SNP_A-2064337, SNP_A-2188491, SNP_A-2165995, SNP_A-1941805, SNP_A-1974593, SNP_A-1798847, SNP_A-2228992, SNP_A-1787457, SNP_A-1654126, SNP_A-1706836, SNP_A-1648555, SNP_A-1697415, SNP_A-1747694, SNP_A-1750840, SNP_A-1682635, SNP_A-1731452, SNP_A-1724764, SNP_A-1731141, SNP_A-1746936, SNP_A-1667490, SNP_A-4257699, SNP_A-1715417, SNP_A-1801378, SNP_A-1672674, SNP_A-1680412, SNP_A-2074150, SNP_A-1853989, SNP_A-4302256, SNP_A-1820244, SNP_A-1940632, SNP_A-2288958, SNP_A-1681177, SNP_A-1700733, SNP_A-1702902, SNP_A-1711631, SNP_A-1757098, SNP_A-1749098, SNP_A-1755897, SNP_A-1882225, SNP_A-1960575, SNP_A-2118450, SNP_A-1874975, SNP_A-1854128, SNP_A-2279369, SNP_A-1699064, SNP_A-1744174, SNP_A-2148973, SNP_A-2097455, SNP_A-1733277, SNP_A-1722401, SNP_A-1736048, SNP_A-2043101, SNP_A-2183034, SNP_A-1646296, SNP_A-1752865, SNP_A-1692480, SNP_A-1698023, SNP_A-1678894, SNP_A-1726900, SNP_A-4194149, SNP_A-4209778, SNP_A-2184664, SNP_A-1882464, SNP_A-1721155, SNP_A-1743363, SNP_A-2145843, SNP_A-4228938,

SNP_A-1882152, SNP_A-2279610, SNP_A-1753291, SNP_A-2251794, SNP_A-1728019, SNP_A-2171765, SNP_A-1694464, SNP_A-2277106, SNP_A-1702878, SNP_A-1852250, SNP_A-1707974, SNP_A-4209785, SNP_A-4209786, SNP_A-1907824, SNP_A-1841940, SNP_A-1974910, SNP_A-1736605, SNP_A-1699515, SNP_A-1693631, SNP_A-1699385, SNP_A-1724182, SNP_A-1701651, SNP_A-1874769, SNP_A-1693523, SNP_A-1694437, SNP_A-2157285, SNP_A-8686732, SNP_A-2221438, SNP_A-2285296, SNP_A-8628781, SNP_A-2069449, SNP_A-1838528, SNP_A-4227156, SNP_A-2192980, SNP_A-1890708, SNP_A-1731616, SNP_A-1735151, SNP_A-1743570, SNP_A-8296677, SNP_A-1756511, SNP_A-1727272, SNP_A-1669837, SNP_A-1975088, SNP_A-1736337, SNP_A-1860966, SNP_A-2039330, SNP_A-1651648, SNP_A-1758507, SNP_A-1853539, SNP_A-1975111, SNP_A-1975114, SNP_A-1683414, SNP_A-1642133, SNP_A-1669499, SNP_A-1927198, SNP_A-4206284, SNP_A-2216930, SNP_A-1930692, SNP_A-1906041, SNP_A-2100641, SNP_A-2208346, SNP_A-4218988, SNP_A-2198949, SNP_A-2027549, SNP_A-1918025, SNP_A-2215185, SNP_A-4228198, SNP_A-2229941, SNP_A-2268875, SNP_A-4214869, SNP_A-1738762, SNP_A-1745331, SNP_A-2159017, SNP_A-1830459, SNP_A-1686853, SNP_A-1744610, SNP_A-1675741, SNP_A-1688834, SNP_A-1706923, SNP_A-1708090, SNP_A-1695209, SNP_A-1688874, SNP_A-1724308, SNP_A-1738178, SNP_A-1672116, SNP_A-1975335, SNP_A-2111332, SNP_A-1945382, SNP_A-2282455, SNP_A-2197337, SNP_A-1915951, SNP_A-1740505, SNP_A-1733904, SNP_A-1751377, SNP_A-1737313, SNP_A-1658044, SNP_A-1650842, SNP_A-1682358, SNP_A-2137845, SNP_A-2009347, SNP_A-2257815, SNP_A-1698103, SNP_A-1728863, SNP_A-1734938, SNP_A-1739699, SNP_A-1650758, SNP_A-2210004, SNP_A-1684435, SNP_A-1684867, SNP_A-1975506, SNP_A-2091886, SNP_A-4224049, SNP_A-1750226, SNP_A-4195314, SNP_A-2261127, SNP_A-2090183, SNP_A-2157345, SNP_A-4209876, SNP_A-1810686, SNP_A-1691917, SNP_A-1695780, SNP_A-1737648, SNP_A-1744592, SNP_A-1749906, SNP_A-1729991, SNP_A-1730392, SNP_A-1738908, SNP_A-1863220, SNP_A-2141304, SNP_A-2116698, SNP_A-1676545, SNP_A-4258544, SNP_A-1727810, SNP_A-1936787, SNP_A-2141576, SNP_A-1734469,

SNP_A-1814831, SNP_A-1698850, SNP_A-1744176, SNP_A-1709535, SNP_A-1657273, SNP_A-1691364, SNP_A-2198327, SNP_A-4209885, SNP_A-1668362, SNP_A-1728903, SNP_A-1676204, SNP_A-1708398, SNP_A-1712213, SNP_A-1667746, SNP_A-1735318, SNP_A-1701223, SNP_A-1790988, SNP_A-2258448, SNP_A-1668188, SNP_A-8717495, SNP_A-1873294, SNP_A-1946029, SNP_A-2241839, SNP_A-1716627, SNP_A-2068710, SNP_A-1784271, SNP_A-1862411, SNP_A-1975569, SNP_A-1735478, SNP_A-2220504, SNP_A-1755646, SNP_A-1975575, SNP_A-1710784, SNP_A-4296611, SNP_A-1719660, SNP_A-2072058, SNP_A-2292149, SNP_A-1652403, SNP_A-1672386, SNP_A-1729720, SNP_A-1731052, SNP_A-1673564, SNP_A-1740491, SNP_A-1654408, SNP_A-1720914, SNP_A-1657140, SNP_A-1714656, SNP_A-1645929, SNP_A-1651167, SNP_A-1752322, SNP_A-2284074, SNP_A-2096670, SNP_A-1727230, SNP_A-1713920, SNP_A-1733892, SNP_A-1729660, SNP_A-1693767, SNP_A-1667974, SNP_A-1927396, SNP_A-1679646, SNP_A-1697923, SNP_A-2064948, SNP_A-1700293, SNP_A-1679934, SNP_A-1975682, SNP_A-1735843, SNP_A-2198811, SNP_A-1752237, SNP_A-1728405, SNP_A-1646546, SNP_A-2304567, SNP_A-2228868, SNP_A-1719351, SNP_A-1672144, SNP_A-1898920, SNP_A-1727787, SNP_A-1839079, SNP_A-1959939, SNP_A-4209909, SNP_A-1662404, SNP_A-1679710, SNP_A-8378640, SNP_A-2086326, SNP_A-2100001, SNP_A-2062267, SNP_A-2034447, SNP_A-1908818, SNP_A-1660998, SNP_A-1706456, SNP_A-1698879, SNP_A-1645390, SNP_A-1703964, SNP_A-1751214, SNP_A-1643612, SNP_A-1667988, SNP_A-1698011, SNP_A-1752633, SNP_A-1652587, SNP_A-1650217, SNP_A-1746851, SNP_A-8336740, SNP_A-2273267, SNP_A-1749184, SNP_A-4269429, SNP_A-8407873, SNP_A-8479718, SNP_A-8653964, SNP_A-1656449, SNP_A-1752539, SNP_A-1753520, SNP_A-4192885, SNP_A-4199051, SNP_A-2121818, SNP_A-2166505, SNP_A-1813834, SNP_A-2307442, SNP_A-1714312, SNP_A-1749890, SNP_A-2118325, SNP_A-2031746, SNP_A-1758420, SNP_A-1658691, SNP_A-1688876, SNP_A-1700675, SNP_A-1937237, SNP_A-2188172, SNP_A-2305493, SNP_A-4256388, SNP_A-1794637, SNP_A-2009496, SNP_A-8363601, SNP_A-8638526, SNP_A-8587696, SNP_A-2136377, SNP_A-8391427, SNP_A-4230111,

SNP_A-1822303, SNP_A-2184274, SNP_A-4284874, SNP_A-1742478, SNP_A-1743918, SNP_A-1682642, SNP_A-1749630, SNP_A-1684301, SNP_A-1733467, SNP_A-1723603, SNP_A-1811027, SNP_A-2049074, SNP_A-2072780, SNP_A-2192432, SNP_A-2224042, SNP_A-1715313, SNP_A-1739136, SNP_A-1753339, SNP_A-1713504, SNP_A-1744437, SNP_A-1741613, SNP_A-8582093, SNP_A-1738883, SNP_A-1645780, SNP_A-2073219, SNP_A-2146725, SNP_A-1685864, SNP_A-1674239, SNP_A-1697875, SNP_A-1650084, SNP_A-2058743, SNP_A-2213514, SNP_A-2247939, SNP_A-1806316, SNP_A-2233478, SNP_A-1860561, SNP_A-2009523, SNP_A-2120708, SNP_A-2244744, SNP_A-1718063, SNP_A-1646260, SNP_A-1735689, SNP_A-1751395, SNP_A-1683580, SNP_A-1758065, SNP_A-1704747, SNP_A-1706957, SNP_A-2214528, SNP_A-2110506, SNP_A-1975904, SNP_A-1648297, SNP_A-1710182, SNP_A-1646667, SNP_A-1691069, SNP_A-4229313, SNP_A-2201404, SNP_A-4276705, SNP_A-1907379, SNP_A-1685355, SNP_A-1727622, SNP_A-1732805, SNP_A-1975982, SNP_A-2270396, SNP_A-1670210, SNP_A-1719294, SNP_A-1655562, SNP_A-1669398, SNP_A-8709726, SNP_A-1976174, SNP_A-8519767, SNP_A-2203724, SNP_A-1810698, SNP_A-1976179, SNP_A-8700838, SNP_A-1706637, SNP_A-1657469, SNP_A-1734574, SNP_A-1644386, SNP_A-1733434, SNP_A-1662434, SNP_A-1729248, SNP_A-1660283, SNP_A-1673452, SNP_A-2222215, SNP_A-2279596, SNP_A-2215951, SNP_A-2108729, SNP_A-4251643, SNP_A-4193406, SNP_A-2139310, SNP_A-1878301, SNP_A-4210023, SNP_A-4302950, SNP_A-2253428, SNP_A-4280006, SNP_A-1976519, SNP_A-1852801, SNP_A-1907283, SNP_A-4210033, SNP_A-2260109, SNP_A-2045267, SNP_A-2074232, SNP_A-1896620, SNP_A-2009664, SNP_A-2277637, SNP_A-2231429, SNP_A-1976582, SNP_A-1901684, SNP_A-1824710, SNP_A-1976605, SNP_A-2238045, SNP_A-1948466, SNP_A-2052209, SNP_A-1896688, SNP_A-1754073, SNP_A-1673318, SNP_A-1685162, SNP_A-1741017, SNP_A-1681414, SNP_A-1685672, SNP_A-1733698, SNP_A-1756537, SNP_A-1697472, SNP_A-1722002, SNP_A-1698679, SNP_A-4194714, SNP_A-4219140, SNP_A-1697523, SNP_A-1650074, SNP_A-1680150, SNP_A-1684530, SNP_A-1757851, SNP_A-1722012, SNP_A-1752461, SNP_A-1668554, SNP_A-1738631,

SNP_A-1676604, SNP_A-1734386, SNP_A-1704487, SNP_A-1736817, SNP_A-1682986, SNP_A-1884157, SNP_A-1955647, SNP_A-2096183, SNP_A-1925483, SNP_A-4271458, SNP_A-1795856, SNP_A-8628931, SNP_A-2045364, SNP_A-4300479, SNP_A-4206143, SNP_A-2239622, SNP_A-8331501, SNP_A-2284718, SNP_A-8621205, SNP_A-8676586, SNP_A-8323651, SNP_A-2009764, SNP_A-4300449, SNP_A-2223673, SNP_A-1673965, SNP_A-1723049, SNP_A-1726797, SNP_A-1728346, SNP_A-1732154, SNP_A-1662871, SNP_A-1742315, SNP_A-1718759, SNP_A-1696398, SNP_A-1710387, SNP_A-1755021, SNP_A-1644154, SNP_A-1691233, SNP_A-1705687, SNP_A-1738640, SNP_A-1646016, SNP_A-1748928, SNP_A-1746741, SNP_A-1729405, SNP_A-1734487, SNP_A-1724044, SNP_A-1755458, SNP_A-1725656, SNP_A-1723387, SNP_A-2092252, SNP_A-1734028, SNP_A-1927598, SNP_A-1660315, SNP_A-1977077, SNP_A-2171410, SNP_A-4232194, SNP_A-4203929, SNP_A-1904139, SNP_A-1871411, SNP_A-2210645, SNP_A-2095729, SNP_A-4264198, SNP_A-2270717, SNP_A-2196354, SNP_A-4234643, SNP_A-2051944, SNP_A-2086717, SNP_A-2229656, SNP_A-4206279, SNP_A-4264200, SNP_A-2292329, SNP_A-1802588, SNP_A-4197746, SNP_A-2109471, SNP_A-1977105, SNP_A-2009801, SNP_A-4250201, SNP_A-1658743, SNP_A-1670843, SNP_A-1712954, SNP_A-1716492, SNP_A-1722363, SNP_A-1715570, SNP_A-1713078, SNP_A-1646005, SNP_A-1692747, SNP_A-1705134, SNP_A-1641782, SNP_A-1709814, SNP_A-1725847, SNP_A-2009816, SNP_A-4210173, SNP_A-1888174, SNP_A-2009819, SNP_A-1801683, SNP_A-1804630, SNP_A-2072548, SNP_A-1715914, SNP_A-4264220, SNP_A-4273704, SNP_A-4271752, SNP_A-4286776, SNP_A-1677846, SNP_A-1803988, SNP_A-2206950, SNP_A-2103331, SNP_A-2135812, SNP_A-4254609, SNP_A-1827592, SNP_A-1652906, SNP_A-2223370, SNP_A-4233580, SNP_A-1852386, SNP_A-1953506, SNP_A-1657433, SNP_A-2118838, SNP_A-1691987, SNP_A-1799074, SNP_A-2116746, SNP_A-1744282, SNP_A-2292416, SNP_A-1673748, SNP_A-1755782, SNP_A-1672456, SNP_A-1700149, SNP_A-8621485, SNP_A-1662768, SNP_A-1715315, SNP_A-1728436, SNP_A-1735279, SNP_A-1679747, SNP_A-1739961, SNP_A-2259194, SNP_A-1714204, SNP_A-1672808, SNP_A-1744889, SNP_A-1647368,

SNP_A-1747375, SNP_A-1737649, SNP_A-1734420, SNP_A-1658324, SNP_A-1739763, SNP_A-1736339, SNP_A-1742517, SNP_A-1726479, SNP_A-4240819, SNP_A-4218524, SNP_A-1977342, SNP_A-1671183, SNP_A-2238559, SNP_A-1819124, SNP_A-1722415, SNP_A-2077787, SNP_A-4217949, SNP_A-2194032, SNP_A-1795007, SNP_A-2059943, SNP_A-1725752, SNP_A-1730661, SNP_A-1723790, SNP_A-1658928, SNP_A-1752619, SNP_A-1676066, SNP_A-2301174, SNP_A-8429145, SNP_A-8634579, SNP_A-8620866, SNP_A-1879653, SNP_A-1959264, SNP_A-8449414, SNP_A-8372181, SNP_A-4252842, SNP_A-8390006, SNP_A-4241956, SNP_A-8429055, SNP_A-2107676, SNP_A-1871392, SNP_A-8314400, SNP_A-1898692, SNP_A-2030335, SNP_A-2151400, SNP_A-2223395, SNP_A-2121108, SNP_A-2194945, SNP_A-4229506, SNP_A-1977762, SNP_A-1734834, SNP_A-1786222, SNP_A-4235225, SNP_A-1653082, SNP_A-1676766, SNP_A-1665776, SNP_A-4264323, SNP_A-2116039, SNP_A-2009949, SNP_A-8309114, SNP_A-2134503, SNP_A-2263195, SNP_A-2312616, SNP_A-8641318, SNP_A-8507792, SNP_A-8641825, SNP_A-8409777, SNP_A-8662196, SNP_A-8410977, SNP_A-8662255, SNP_A-8695453, SNP_A-2156517, SNP_A-2312397, SNP_A-2097874, SNP_A-8364867, SNP_A-2257849, SNP_A-4247441, SNP_A-1928467, SNP_A-2171122, SNP_A-1929002, SNP_A-2189661, SNP_A-2087896, SNP_A-4294440, SNP_A-4240325, SNP_A-8508148, SNP_A-1961136, SNP_A-2207109, SNP_A-2125940, SNP_A-1933893, SNP_A-2259333, SNP_A-1909638, SNP_A-1869632, SNP_A-8497892, SNP_A-2290821, SNP_A-2026577, SNP_A-2184321, SNP_A-1820266, SNP_A-8530039, SNP_A-1895705, SNP_A-4275993, SNP_A-1978214, SNP_A-8305077, SNP_A-2048813, SNP_A-8688281, SNP_A-2179909, SNP_A-4264387, SNP_A-2248399, SNP_A-8597563, SNP_A-2285165, SNP_A-8412183, SNP_A-8652000, SNP_A-8556671, SNP_A-1833842, SNP_A-2033858, SNP_A-2263722, SNP_A-2206609, SNP_A-8294466, SNP_A-8300358, SNP_A-2070751, SNP_A-2262415, SNP_A-2170364, SNP_A-8363177, SNP_A-1842764, SNP_A-1806164, SNP_A-1978232, SNP_A-4247878, SNP_A-8533915, SNP_A-2010010, SNP_A-2297072, SNP_A-4264392, SNP_A-2038424, SNP_A-8662743, SNP_A-8396153, SNP_A-1861620, SNP_A-4206414, SNP_A-1978240, SNP_A-1978241,

SNP_A-8662751, SNP_A-8422230, SNP_A-4259300, SNP_A-8367073, SNP_A-8503971, SNP_A-8523885, SNP_A-8572099, SNP_A-1738119, SNP_A-1744572, SNP_A-1679203, SNP_A-1686411, SNP_A-1731888, SNP_A-1738976, SNP_A-1718812, SNP_A-1724241, SNP_A-1727690, SNP_A-1656752, SNP_A-1726278, SNP_A-1707679, SNP_A-1725820, SNP_A-1751813, SNP_A-1648590, SNP_A-2252163, SNP_A-2200090, SNP_A-1953409, SNP_A-1731889, SNP_A-1707557, SNP_A-1679162, SNP_A-1734134, SNP_A-1677610, SNP_A-1663322, SNP_A-1756230, SNP_A-1745454, SNP_A-1685320, SNP_A-2252897, SNP_A-4197792, SNP_A-1690760, SNP_A-1692651, SNP_A-1744880, SNP_A-1674422, SNP_A-1718724, SNP_A-1930084, SNP_A-2108500, SNP_A-4299199, SNP_A-4205604, SNP_A-1951629, SNP_A-2115932, SNP_A-4247585, SNP_A-8468660, SNP_A-8433358, SNP_A-8543168, SNP_A-1793750, SNP_A-4225986, SNP_A-8371115, SNP_A-2115482, SNP_A-4242153, SNP_A-8662422, SNP_A-2045524, SNP_A-2159496, SNP_A-4277372, SNP_A-4195751, SNP_A-1979014, SNP_A-4204820, SNP_A-4222694, SNP_A-1885084, SNP_A-1728081, SNP_A-1672216, SNP_A-1695795, SNP_A-1742137, SNP_A-1741183, SNP_A-1683798, SNP_A-1710495, SNP_A-2055998, SNP_A-8662800, SNP_A-8530949, SNP_A-2027156, SNP_A-2010191, SNP_A-8335409, SNP_A-8662802, SNP_A-8692152, SNP_A-2105230, SNP_A-1888385, SNP_A-8662807, SNP_A-8694963, SNP_A-1854790, SNP_A-8390130, SNP_A-2235329, SNP_A-4210580, SNP_A-8517065, SNP_A-8662856, SNP_A-1947475, SNP_A-8628331, SNP_A-2219817, SNP_A-2088172, SNP_A-1825150, SNP_A-1820362, SNP_A-1730944, SNP_A-1747864, SNP_A-1751646, SNP_A-1676613, SNP_A-1687467, SNP_A-2267261, SNP_A-1683486, SNP_A-1671358, SNP_A-1719657, SNP_A-1671710, SNP_A-1696600, SNP_A-1723805, SNP_A-1653135, SNP_A-1723491, SNP_A-1668329, SNP_A-1644963, SNP_A-1653699, SNP_A-1699014, SNP_A-1714746, SNP_A-1753082, SNP_A-2157138, SNP_A-2021459, SNP_A-1979310, SNP_A-2178640, SNP_A-1817980, SNP_A-4247709, SNP_A-4154924, SNP_A-8604211, SNP_A-1938046, SNP_A-1914590, SNP_A-1874482, SNP_A-2200353, SNP_A-2029775, SNP_A-8370256, SNP_A-8591191, SNP_A-2150472, SNP_A-1956828, SNP_A-4230684, SNP_A-1873019, SNP_A-2065502,

SNP_A-2240473, SNP_A-8383301, SNP_A-4264571, SNP_A-2200867, SNP_A-2200788, SNP_A-1979489, SNP_A-1932993, SNP_A-2108049, SNP_A-1676274, SNP_A-1662866, SNP_A-1693481, SNP_A-1720679, SNP_A-1734140, SNP_A-1713956, SNP_A-2084348, SNP_A-2117606, SNP_A-8613200, SNP_A-2271613, SNP_A-2152198, SNP_A-8460937, SNP_A-1735352, SNP_A-1692606, SNP_A-1676394, SNP_A-1671570, SNP_A-2277532, SNP_A-2010321, SNP_A-1755208, SNP_A-1946815, SNP_A-4303169, SNP_A-2230569, SNP_A-2135482, SNP_A-2161535, SNP_A-2101654, SNP_A-1738681, SNP_A-1736063, SNP_A-1667142, SNP_A-1669587, SNP_A-1716509, SNP_A-4201449, SNP_A-1979707, SNP_A-1979709, SNP_A-1659502, SNP_A-1651010, SNP_A-1679230, SNP_A-1721482, SNP_A-1652492, SNP_A-1732490, SNP_A-1665766, SNP_A-1726454, SNP_A-1708286, SNP_A-1755366, SNP_A-1718121, SNP_A-8306092, SNP_A-8682165, SNP_A-8582271, SNP_A-2128327, SNP_A-8662070, SNP_A-8336330, SNP_A-8662687, SNP_A-4264628, SNP_A-1801988, SNP_A-1862835, SNP_A-4219807, SNP_A-1944684, SNP_A-8432932, SNP_A-4241029, SNP_A-1841397, SNP_A-4256013, SNP_A-2132328, SNP_A-1920023, SNP_A-1756506, SNP_A-1737086, SNP_A-1746802, SNP_A-1673887, SNP_A-1719662, SNP_A-1723569, SNP_A-4274293, SNP_A-1820564, SNP_A-1884896, SNP_A-2010459, SNP_A-4215001, SNP_A-1980087, SNP_A-2066444, SNP_A-1980145, SNP_A-1693748, SNP_A-1843410, SNP_A-1747728, SNP_A-2141791, SNP_A-1679179, SNP_A-1722141, SNP_A-1660038, SNP_A-1665393, SNP_A-2237836, SNP_A-1874531, SNP_A-1893855, SNP_A-1709725, SNP_A-1674777, SNP_A-1690457, SNP_A-1717387, SNP_A-1694123, SNP_A-1687846, SNP_A-1645796, SNP_A-1757787, SNP_A-1713534, SNP_A-1742067, SNP_A-2010546, SNP_A-1708254, SNP_A-1908938, SNP_A-4282847, SNP_A-8542641, SNP_A-1682482, SNP_A-1669507, SNP_A-1708691, SNP_A-1675770, SNP_A-1664669, SNP_A-2301403, SNP_A-1675228, SNP_A-1715274, SNP_A-1647694, SNP_A-1722315, SNP_A-1729367, SNP_A-1658475, SNP_A-2193730, SNP_A-4251736, SNP_A-4232136, SNP_A-1749770, SNP_A-8432444, SNP_A-8362319, SNP_A-4236757, SNP_A-8485090, SNP_A-2280280, SNP_A-1716816, SNP_A-1811165, SNP_A-1666782, SNP_A-1668813, SNP_A-1643736,

SNP_A-1651170, SNP_A-1692535, SNP_A-1755316, SNP_A-1687890, SNP_A-2185969, SNP_A-1874194, SNP_A-2213645, SNP_A-2272681, SNP_A-2279802, SNP_A-2259204, SNP_A-1871066, SNP_A-4244100, SNP_A-1872609, SNP_A-2298408, SNP_A-1885490, SNP_A-2095499, SNP_A-2175105, SNP_A-2285943, SNP_A-2193244, SNP_A-1669859, SNP_A-1747384, SNP_A-1689409, SNP_A-1670823, SNP_A-2112999, SNP_A-2034049, SNP_A-1785688, SNP_A-1886415, SNP_A-2203054, SNP_A-8397690, SNP_A-2233098, SNP_A-2180751, SNP_A-2118190, SNP_A-1980387, SNP_A-2286514, SNP_A-1922652, SNP_A-1980413, SNP_A-1648517, SNP_A-1678607, SNP_A-1729927, SNP_A-2205397, SNP_A-1725015, SNP_A-4155814, SNP_A-1917012, SNP_A-1667565, SNP_A-1713613, SNP_A-1653311, SNP_A-1712968, SNP_A-1955958, SNP_A-1823865, SNP_A-1937910, SNP_A-4216256, SNP_A-2215327, SNP_A-1649915, SNP_A-1752642, SNP_A-1694446, SNP_A-1744976, SNP_A-1681473, SNP_A-1695648, SNP_A-1897566, SNP_A-2184513, SNP_A-2286370, SNP_A-2210869, SNP_A-2260522, SNP_A-1687276, SNP_A-1643387, SNP_A-1670351, SNP_A-1652326, SNP_A-1697959, SNP_A-1730114, SNP_A-1680513, SNP_A-1657163, SNP_A-1665337, SNP_A-1686060, SNP_A-1656088, SNP_A-1745201, SNP_A-1683655, SNP_A-2046224, SNP_A-2098728, SNP_A-1718702, SNP_A-2248841, SNP_A-1732669, SNP_A-1665441, SNP_A-1717980, SNP_A-1702512, SNP_A-1713282, SNP_A-1727147, SNP_A-1661473, SNP_A-1715334, SNP_A-4274418, SNP_A-8651876, SNP_A-1909330, SNP_A-8427561, SNP_A-2162871, SNP_A-1715549, SNP_A-8511658, SNP_A-8329689, SNP_A-1688028, SNP_A-1829082, SNP_A-1729320, SNP_A-1650504, SNP_A-8413174, SNP_A-8603700, SNP_A-1700783, SNP_A-1705823, SNP_A-8481851, SNP_A-1673802, SNP_A-2201364, SNP_A-8311030, SNP_A-1980993, SNP_A-4230550, SNP_A-1920046, SNP_A-1651860, SNP_A-1695035, SNP_A-8495041, SNP_A-1663638, SNP_A-2231493, SNP_A-1712895, SNP_A-2076496, SNP_A-2248218, SNP_A-8527640, SNP_A-1672444, SNP_A-1717767, SNP_A-2089430, SNP_A-2129969, SNP_A-4210880, SNP_A-4210881, SNP_A-1704003, SNP_A-1720627, SNP_A-1660081, SNP_A-1673276, SNP_A-1981118, SNP_A-4205427, SNP_A-2127826, SNP_A-8664442, SNP_A-1711720, SNP_A-1678668,

SNP_A-1691592, SNP_A-1650898, SNP_A-1677388, SNP_A-1672580, SNP_A-1812330, SNP_A-1681269, SNP_A-1720518, SNP_A-1724049, SNP_A-1729333, SNP_A-1663605, SNP_A-1716118, SNP_A-1651177, SNP_A-1656248, SNP_A-1708463, SNP_A-1648375, SNP_A-1675824, SNP_A-1710527, SNP_A-1725522, SNP_A-1673094, SNP_A-1684142, SNP_A-1710590, SNP_A-1716743, SNP_A-1714903, SNP_A-1741720, SNP_A-1678297, SNP_A-1684020, SNP_A-1749041, SNP_A-2171229, SNP_A-2010860, SNP_A-2074637, SNP_A-2105012, SNP_A-1728794, SNP_A-1699509, SNP_A-1682656, SNP_A-1722961, SNP_A-1662349, SNP_A-1669094, SNP_A-1758245, SNP_A-1719990, SNP_A-1735883, SNP_A-1785206, SNP_A-1658279, SNP_A-2233888, SNP_A-2023550, SNP_A-4283934, SNP_A-4282307, SNP_A-8374306, SNP_A-4235833, SNP_A-1851485, SNP_A-2060384, SNP_A-1682798, SNP_A-1683690, SNP_A-1681834, SNP_A-1658866, SNP_A-1749029, SNP_A-2302004, SNP_A-1981615, SNP_A-4205932, SNP_A-2054574, SNP_A-2277284, SNP_A-8462077, SNP_A-4238908, SNP_A-2258765, SNP_A-1981780, SNP_A-2142698, SNP_A-1955796, SNP_A-4210979, SNP_A-2121761, SNP_A-1930543, SNP_A-4201982, SNP_A-1981870, SNP_A-8378960, SNP_A-8432947, SNP_A-8639675, SNP_A-8437376, SNP_A-8538146, SNP_A-2289275, SNP_A-2102854, SNP_A-4234376, SNP_A-2184342, SNP_A-1914683, SNP_A-1669193, SNP_A-1713904, SNP_A-1695151, SNP_A-1698849, SNP_A-1750057, SNP_A-1724316, SNP_A-8380957, SNP_A-8530720, SNP_A-1898922, SNP_A-2214843, SNP_A-1982050, SNP_A-8521285, SNP_A-8388898, SNP_A-8597681, SNP_A-2311298, SNP_A-1796622, SNP_A-1859919, SNP_A-8666295, SNP_A-1982201, SNP_A-2031578, SNP_A-4234852, SNP_A-4278438, SNP_A-8546106, SNP_A-8466053, SNP_A-8306098, SNP_A-4211061, SNP_A-1838271, SNP_A-8391648, SNP_A-2218142, SNP_A-8663793, SNP_A-1982372, SNP_A-1827719, SNP_A-2187420, SNP_A-4232591, SNP_A-1912891, SNP_A-2099367, SNP_A-1982401, SNP_A-2132350, SNP_A-1881285, SNP_A-1982404, SNP_A-4285807, SNP_A-4283561, SNP_A-2199069, SNP_A-1815391, SNP_A-4291553, SNP_A-2044506, SNP_A-2308464, SNP_A-4259618, SNP_A-2283938, SNP_A-1881789, SNP_A-1982426, SNP_A-2155589, SNP_A-1958765, SNP_A-1959803, SNP_A-1789551,

SNP_A-4205532, SNP_A-4229913, SNP_A-1982478, SNP_A-2261689, SNP_A-1948856, SNP_A-1703002, SNP_A-1754125, SNP_A-1684951, SNP_A-1691951, SNP_A-1682919, SNP_A-1728804, SNP_A-2030542, SNP_A-4236700, SNP_A-2198413, SNP_A-1941126, SNP_A-2089765, SNP_A-4211104, SNP_A-2053045, SNP_A-1669284, SNP_A-1727398, SNP_A-1657837, SNP_A-1665255, SNP_A-1679273, SNP_A-1682725, SNP_A-1691659, SNP_A-1735634, SNP_A-1781591, SNP_A-1823686, SNP_A-1797614, SNP_A-4204545, SNP_A-2080906, SNP_A-1715791, SNP_A-1719228, SNP_A-1685088, SNP_A-1715132, SNP_A-1742957, SNP_A-1740258, SNP_A-4234604, SNP_A-1883541, SNP_A-2198304, SNP_A-2249993, SNP_A-1950705, SNP_A-1699428, SNP_A-1744514, SNP_A-1691243, SNP_A-1693273, SNP_A-1673401, SNP_A-1729641, SNP_A-1739622, SNP_A-1753038, SNP_A-1689123, SNP_A-1798741, SNP_A-8357107, SNP_A-4247859, SNP_A-2131876, SNP_A-1892230, SNP_A-1982745, SNP_A-8558795, SNP_A-1718787, SNP_A-1702267, SNP_A-1720437, SNP_A-1731135, SNP_A-1669026, SNP_A-1661741, SNP_A-1710438, SNP_A-2031912, SNP_A-4265105, SNP_A-1742689, SNP_A-1645814, SNP_A-1729846, SNP_A-1665452, SNP_A-8350322, SNP_A-2074182, SNP_A-8300862, SNP_A-8544496, SNP_A-2246001, SNP_A-4195972, SNP_A-8358799, SNP_A-4265126, SNP_A-4275845, SNP_A-4265130, SNP_A-2093465, SNP_A-8666323, SNP_A-1781901, SNP_A-4225077, SNP_A-1793033, SNP_A-1727784, SNP_A-1658629, SNP_A-1671277, SNP_A-1714828, SNP_A-1707174, SNP_A-8666555, SNP_A-4194190, SNP_A-2189318, SNP_A-2233488, SNP_A-1983101, SNP_A-8335430, SNP_A-1675197, SNP_A-1744467, SNP_A-1723534, SNP_A-1706565, SNP_A-1655921, SNP_A-1729838, SNP_A-1657894, SNP_A-1680380, SNP_A-1673342, SNP_A-2132991, SNP_A-1786659, SNP_A-2303290, SNP_A-1854856, SNP_A-8491445, SNP_A-1954211, SNP_A-4247201, SNP_A-8442510, SNP_A-1740168, SNP_A-1741626, SNP_A-1737666, SNP_A-1713691, SNP_A-1717410, SNP_A-1725289, SNP_A-1710109, SNP_A-1703293, SNP_A-1728529, SNP_A-1750477, SNP_A-1683132, SNP_A-1703093, SNP_A-1725632, SNP_A-1710981, SNP_A-1745931, SNP_A-1753130, SNP_A-1660476, SNP_A-1668986, SNP_A-2193888, SNP_A-2114862, SNP_A-1644094, SNP_A-1740757,

SNP_A-1661324, SNP_A-1705453, SNP_A-1642016, SNP_A-1646209, SNP_A-1687561, SNP_A-1722096, SNP_A-1749899, SNP_A-1703390, SNP_A-1834543, SNP_A-2210260, SNP_A-1855314, SNP_A-2164573, SNP_A-2092303, SNP_A-1868450, SNP_A-2305779, SNP_A-4265261, SNP_A-2193741, SNP_A-1676812, SNP_A-4233782, SNP_A-1735578, SNP_A-1750213, SNP_A-1718335, SNP_A-1754440, SNP_A-1673208, SNP_A-2163324, SNP_A-2124947, SNP_A-1648046, SNP_A-1709975, SNP_A-1703618, SNP_A-1730374, SNP_A-1743998, SNP_A-4228563, SNP_A-1880882, SNP_A-1983822, SNP_A-1662301, SNP_A-1785166, SNP_A-2145127, SNP_A-2100411, SNP_A-1679302, SNP_A-1694513, SNP_A-1709785, SNP_A-1719933, SNP_A-1675620, SNP_A-1665038, SNP_A-1685908, SNP_A-1683886, SNP_A-1720643, SNP_A-1708086, SNP_A-1669925, SNP_A-1661125, SNP_A-1736451, SNP_A-1731031, SNP_A-1697515, SNP_A-1660309, SNP_A-1732928, SNP_A-1669471, SNP_A-1729328, SNP_A-1930139, SNP_A-1648940, SNP_A-1746312, SNP_A-1727248, SNP_A-2217370, SNP_A-1668156, SNP_A-1682248, SNP_A-1703019, SNP_A-1755780, SNP_A-1683474, SNP_A-2170969, SNP_A-2210338, SNP_A-1783629, SNP_A-1680488, SNP_A-1895638, SNP_A-1647560, SNP_A-1813438, SNP_A-1728192, SNP_A-1676237, SNP_A-1678329, SNP_A-1729375, SNP_A-8378623, SNP_A-2091282, SNP_A-1815538, SNP_A-4265321, SNP_A-1984112, SNP_A-1984125, SNP_A-2077771, SNP_A-1984172, SNP_A-1653659, SNP_A-1659015, SNP_A-2120317, SNP_A-2256044, SNP_A-1700038, SNP_A-1691435, SNP_A-1745157, SNP_A-1869133, SNP_A-4225263, SNP_A-1919454, SNP_A-2295105, SNP_A-2194798, SNP_A-4218293, SNP_A-1984249, SNP_A-2261458, SNP_A-2254850, SNP_A-1849213, SNP_A-2228163, SNP_A-1984293, SNP_A-8375335, SNP_A-4256224, SNP_A-2048052, SNP_A-2103902, SNP_A-2162461, SNP_A-1934446, SNP_A-2115695, SNP_A-2266465, SNP_A-1725897, SNP_A-1732851, SNP_A-1667279, SNP_A-1669220, SNP_A-1725397, SNP_A-1656148, SNP_A-1659749, SNP_A-2011434, SNP_A-4245990, SNP_A-8531596, SNP_A-2176563, SNP_A-1738789, SNP_A-1656549, SNP_A-1744541, SNP_A-1675904, SNP_A-1744565, SNP_A-1756256, SNP_A-2186384, SNP_A-4295469, SNP_A-1728320, SNP_A-1702626, SNP_A-1747544, SNP_A-1681001,

SNP_A-1686183, SNP_A-1679985, SNP_A-2209134, SNP_A-2096303, SNP_A-1726789, SNP_A-1685451, SNP_A-8470112, SNP_A-2209932, SNP_A-1876441, SNP_A-1984617, SNP_A-1984634, SNP_A-2224308, SNP_A-1736511, SNP_A-1665646, SNP_A-1713170, SNP_A-1735440, SNP_A-1649549, SNP_A-1680220, SNP_A-1707528, SNP_A-1675518, SNP_A-1683648, SNP_A-1689130, SNP_A-1737956, SNP_A-1708705, SNP_A-1730867, SNP_A-1720951, SNP_A-1722382, SNP_A-1743007, SNP_A-1984705, SNP_A-2241598, SNP_A-2263122, SNP_A-1675071, SNP_A-1789757, SNP_A-1654701, SNP_A-1949294, SNP_A-2248508, SNP_A-2126348, SNP_A-1889799, SNP_A-1902848, SNP_A-1697056, SNP_A-1656465, SNP_A-1731729, SNP_A-1648422, SNP_A-1730157, SNP_A-1733265, SNP_A-1680572, SNP_A-1676477, SNP_A-1699384, SNP_A-1725590, SNP_A-1646185, SNP_A-1756523, SNP_A-1683255, SNP_A-1690498, SNP_A-1736198, SNP_A-1748220, SNP_A-1676103, SNP_A-4224841, SNP_A-2156172, SNP_A-1984752, SNP_A-1718529, SNP_A-1676538, SNP_A-1648650, SNP_A-2189759, SNP_A-1784897, SNP_A-1643129, SNP_A-1740531, SNP_A-1984764, SNP_A-2102297, SNP_A-1792345, SNP_A-2232437, SNP_A-4197530, SNP_A-1984777, SNP_A-1815923, SNP_A-8635747, SNP_A-8496832, SNP_A-1872800, SNP_A-2130222, SNP_A-2197542, SNP_A-8568903, SNP_A-8580841, SNP_A-8607881, SNP_A-8611542, SNP_A-2028119, SNP_A-4237889, SNP_A-1877405, SNP_A-4276312, SNP_A-2011549, SNP_A-2021853, SNP_A-2143375, SNP_A-2142847, SNP_A-8652013, SNP_A-4204888, SNP_A-2248310, SNP_A-8431846, SNP_A-8292810, SNP_A-8715306, SNP_A-2035288, SNP_A-2011570, SNP_A-1817957, SNP_A-2208427, SNP_A-8589026, SNP_A-8354647, SNP_A-8513714, SNP_A-2242578, SNP_A-1902497, SNP_A-8446352, SNP_A-8612437, SNP_A-8667754, SNP_A-1820081, SNP_A-8480998, SNP_A-8363023, SNP_A-2177026, SNP_A-2126692, SNP_A-2112415, SNP_A-1985190, SNP_A-2029230, SNP_A-2078111, SNP_A-1915399, SNP_A-1959277, SNP_A-2086815, SNP_A-2139822, SNP_A-2241443, SNP_A-4205653, SNP_A-2042439, SNP_A-4287528, SNP_A-4281902, SNP_A-2254148, SNP_A-4304075, SNP_A-1750045, SNP_A-1644774, SNP_A-1727062, SNP_A-1753565, SNP_A-1683999, SNP_A-1689509, SNP_A-1734987, SNP_A-1746978,

SNP_A-1687201, SNP_A-1720620, SNP_A-1699051, SNP_A-1687786, SNP_A-1744783, SNP_A-1786991, SNP_A-1834929, SNP_A-1733644, SNP_A-1709641, SNP_A-1745055, SNP_A-1645990, SNP_A-1680548, SNP_A-1758485, SNP_A-1708426, SNP_A-1666360, SNP_A-1757675, SNP_A-1985556, SNP_A-4240292, SNP_A-4197063, SNP_A-4198042, SNP_A-8660483, SNP_A-8436373, SNP_A-2121087, SNP_A-2187451, SNP_A-8427588, SNP_A-1824170, SNP_A-4193499, SNP_A-8469773, SNP_A-1790799, SNP_A-2222969, SNP_A-8686195, SNP_A-2237038, SNP_A-8400374, SNP_A-1753875, SNP_A-1757811, SNP_A-1664344, SNP_A-1691556, SNP_A-1840874, SNP_A-2115862, SNP_A-4219559, SNP_A-1707513, SNP_A-2112034, SNP_A-1669117, SNP_A-1704795, SNP_A-1662894, SNP_A-1686822, SNP_A-4256303, SNP_A-2219560, SNP_A-1912779, SNP_A-1668781, SNP_A-1708412, SNP_A-1742953, SNP_A-1676458, SNP_A-1758373, SNP_A-1678196, SNP_A-1703323, SNP_A-1910668, SNP_A-2159207, SNP_A-4202000, SNP_A-1719590, SNP_A-1657797, SNP_A-1687575, SNP_A-1734881, SNP_A-1743304, SNP_A-1745301, SNP_A-1732270, SNP_A-2113351, SNP_A-2238476, SNP_A-2177235, SNP_A-1896262, SNP_A-1855859, SNP_A-2045728, SNP_A-4271898, SNP_A-2236920, SNP_A-2199335, SNP_A-2297911, SNP_A-2218998, SNP_A-2228836, SNP_A-1985829, SNP_A-2312672, SNP_A-2090229, SNP_A-2114134, SNP_A-1911954, SNP_A-2141771, SNP_A-1785735, SNP_A-1854421, SNP_A-2177059, SNP_A-4249919, SNP_A-1887999, SNP_A-1700310, SNP_A-1707538, SNP_A-1697932, SNP_A-1748380, SNP_A-2202762, SNP_A-1650815, SNP_A-2091015, SNP_A-1655496, SNP_A-2311743, SNP_A-4211608, SNP_A-1985871, SNP_A-2080920, SNP_A-1664068, SNP_A-1813951, SNP_A-4205722, SNP_A-1985885, SNP_A-1652504, SNP_A-2257829, SNP_A-2042065, SNP_A-1666104, SNP_A-2247171, SNP_A-2022164, SNP_A-1667268, SNP_A-1650198, SNP_A-1697124, SNP_A-1658404, SNP_A-1732141, SNP_A-1662816, SNP_A-2133829, SNP_A-1986045, SNP_A-2247213, SNP_A-8565557, SNP_A-4233404, SNP_A-2118525, SNP_A-8321966, SNP_A-2070464, SNP_A-1888498, SNP_A-2028464, SNP_A-1793000, SNP_A-2129426, SNP_A-1953448, SNP_A-1840574, SNP_A-2132217, SNP_A-1872730, SNP_A-1651296, SNP_A-1718801, SNP_A-1709753,

SNP_A-1712073, SNP_A-1754886, SNP_A-1744253, SNP_A-1711456, SNP_A-1712019, SNP_A-1738004, SNP_A-1659205, SNP_A-1667166, SNP_A-1682743, SNP_A-1648526, SNP_A-2229635, SNP_A-2184999, SNP_A-2075353, SNP_A-8323464, SNP_A-4265691, SNP_A-2130487, SNP_A-4299657, SNP_A-1792392, SNP_A-2084244, SNP_A-1876961, SNP_A-2098172, SNP_A-1907749, SNP_A-1808455, SNP_A-1806874, SNP_A-2054742, SNP_A-2235923, SNP_A-1900753, SNP_A-1986228, SNP_A-4248801, SNP_A-4237658, SNP_A-1724646, SNP_A-1841454, SNP_A-1730695, SNP_A-1712157, SNP_A-1748925, SNP_A-1752893, SNP_A-1698743, SNP_A-1838735, SNP_A-1722983, SNP_A-1728688, SNP_A-1735125, SNP_A-1660964, SNP_A-1726023, SNP_A-1663905, SNP_A-1679771, SNP_A-1756917, SNP_A-1695091, SNP_A-1695499, SNP_A-1729148, SNP_A-1684856, SNP_A-1758448, SNP_A-1754658, SNP_A-1738445, SNP_A-4234225, SNP_A-2312960, SNP_A-2243083, SNP_A-8555122, SNP_A-2241520, SNP_A-8464478, SNP_A-8421574, SNP_A-4231181, SNP_A-1646140, SNP_A-1692344, SNP_A-1682794, SNP_A-1922142, SNP_A-4211770, SNP_A-4232946, SNP_A-1701085, SNP_A-1879226, SNP_A-2139073, SNP_A-4257018, SNP_A-2130339, SNP_A-2274145, SNP_A-1885187, SNP_A-1914333, SNP_A-2255258, SNP_A-2268585, SNP_A-1947966, SNP_A-2233656, SNP_A-8444943, SNP_A-8463580, SNP_A-8545299, SNP_A-8523779, SNP_A-4265773, SNP_A-4253686, SNP_A-2201442, SNP_A-1937961, SNP_A-2262485, SNP_A-1986712, SNP_A-1986713, SNP_A-2252128, SNP_A-1728332, SNP_A-1730341, SNP_A-1736724, SNP_A-1668023, SNP_A-1718718, SNP_A-1734803, SNP_A-2206875, SNP_A-2281983, SNP_A-2092319, SNP_A-4216218, SNP_A-4226607, SNP_A-4211816, SNP_A-1797856, SNP_A-1815130, SNP_A-1856856, SNP_A-2086312, SNP_A-2026348, SNP_A-4296739, SNP_A-1916249, SNP_A-2140934, SNP_A-1986804, SNP_A-1946757, SNP_A-1813450, SNP_A-1706702, SNP_A-1710516, SNP_A-1645315, SNP_A-1744320, SNP_A-1680783, SNP_A-1691079, SNP_A-1682129, SNP_A-1727800, SNP_A-1739916, SNP_A-1694012, SNP_A-1708217, SNP_A-1755197, SNP_A-1909297, SNP_A-1986905, SNP_A-2070129, SNP_A-4292976, SNP_A-2091267, SNP_A-1865806, SNP_A-1843977, SNP_A-2264668, SNP_A-1927968, SNP_A-2246701,

SNP_A-4204522, SNP_A-2037706, SNP_A-8318320, SNP_A-8311112, SNP_A-8424646, SNP_A-4211868, SNP_A-8543403, SNP_A-4238620, SNP_A-1952132, SNP_A-1905093, SNP_A-2076079, SNP_A-4203004, SNP_A-2178008, SNP_A-1948488, SNP_A-1987043, SNP_A-1987046, SNP_A-2125742, SNP_A-2274921, SNP_A-4239751, SNP_A-1650591, SNP_A-1694048, SNP_A-1748062, SNP_A-1753900, SNP_A-1700499, SNP_A-1754567, SNP_A-1746506, SNP_A-1649602, SNP_A-1727459, SNP_A-1692518, SNP_A-1670007, SNP_A-1683080, SNP_A-4211884, SNP_A-1653558, SNP_A-1701217, SNP_A-1673655, SNP_A-1678869, SNP_A-1687697, SNP_A-1672751, SNP_A-1987160, SNP_A-1674724, SNP_A-1672279, SNP_A-1854372, SNP_A-2213700, SNP_A-1720270, SNP_A-1710222, SNP_A-1721148, SNP_A-1712790, SNP_A-1643813, SNP_A-1692603, SNP_A-1698000, SNP_A-1701624, SNP_A-1835854, SNP_A-1723591, SNP_A-2281941, SNP_A-2155351, SNP_A-1682844, SNP_A-1753105, SNP_A-1712583, SNP_A-1731005, SNP_A-1758788, SNP_A-1707766, SNP_A-2152211, SNP_A-4236860, SNP_A-1925274, SNP_A-2257509, SNP_A-1948490, SNP_A-1987300, SNP_A-2233516, SNP_A-2302435, SNP_A-2146355, SNP_A-4201673, SNP_A-1850499, SNP_A-8700132, SNP_A-8517502, SNP_A-8408705, SNP_A-4211929, SNP_A-1987381, SNP_A-8418400, SNP_A-1698920, SNP_A-1647991, SNP_A-1666937, SNP_A-1677943, SNP_A-1733889, SNP_A-1661044, SNP_A-1664663, SNP_A-1792210, SNP_A-1837549, SNP_A-1711155, SNP_A-1642140, SNP_A-1646371, SNP_A-1694818, SNP_A-1702076, SNP_A-1747166, SNP_A-1690568, SNP_A-1737674, SNP_A-1987489, SNP_A-1899901, SNP_A-2214428, SNP_A-2027191, SNP_A-2168374, SNP_A-1892433, SNP_A-2026998, SNP_A-2087900, SNP_A-8558432, SNP_A-2158603, SNP_A-2265016, SNP_A-8669968, SNP_A-8670226, SNP_A-2162196, SNP_A-4211968, SNP_A-2062201, SNP_A-1952671, SNP_A-8547464, SNP_A-1875817, SNP_A-2112563, SNP_A-2289815, SNP_A-8670553, SNP_A-8552165, SNP_A-1818867, SNP_A-2240961, SNP_A-1987684, SNP_A-4211992, SNP_A-1707993, SNP_A-1987746, SNP_A-1701914, SNP_A-1710444, SNP_A-1645111, SNP_A-1697425, SNP_A-1706388, SNP_A-1750182, SNP_A-2156123, SNP_A-1892600, SNP_A-2277332, SNP_A-4256489, SNP_A-2035854, SNP_A-2073748,

SNP_A-1987789, SNP_A-1920919, SNP_A-1675030, SNP_A-1682363, SNP_A-1731526, SNP_A-1670627, SNP_A-1660114, SNP_A-1663425, SNP_A-1662715, SNP_A-2239509, SNP_A-2258624, SNP_A-1801053, SNP_A-1797814, SNP_A-1987906, SNP_A-4238866, SNP_A-1927125, SNP_A-4217319, SNP_A-2012127, SNP_A-1884706, SNP_A-2224709, SNP_A-4195393, SNP_A-4215174, SNP_A-2266222, SNP_A-2138457, SNP_A-2042585, SNP_A-4212034, SNP_A-4206228, SNP_A-1660332, SNP_A-1709124, SNP_A-1647113, SNP_A-1654092, SNP_A-1805827, SNP_A-2144266, SNP_A-1928090, SNP_A-8416833, SNP_A-8529811, SNP_A-8693075, SNP_A-2238574, SNP_A-4236492, SNP_A-2098057, SNP_A-2308715, SNP_A-2066660, SNP_A-1832721, SNP_A-2210173, SNP_A-2031564, SNP_A-1791333, SNP_A-1726710, SNP_A-1723826, SNP_A-1667080, SNP_A-1741721, SNP_A-1721998, SNP_A-1857374, SNP_A-1727695, SNP_A-1718229, SNP_A-1721444, SNP_A-1678442, SNP_A-8525723, SNP_A-1652442, SNP_A-1683320, SNP_A-1718770, SNP_A-1653411, SNP_A-1660302, SNP_A-1988209, SNP_A-1871277, SNP_A-1707991, SNP_A-1753724, SNP_A-1653215, SNP_A-1643616, SNP_A-1697488, SNP_A-1714055, SNP_A-4266043, SNP_A-2276361, SNP_A-1645158, SNP_A-1683492, SNP_A-1740699, SNP_A-1701225, SNP_A-1738092, SNP_A-1725058, SNP_A-1704367, SNP_A-1668700, SNP_A-1703773, SNP_A-1758913, SNP_A-1652984, SNP_A-1687034, SNP_A-1752517, SNP_A-1650378, SNP_A-1650706, SNP_A-2250462, SNP_A-2222115, SNP_A-1939299, SNP_A-1870456, SNP_A-4251098, SNP_A-4296921, SNP_A-1988306, SNP_A-2012210, SNP_A-1988313, SNP_A-1731735, SNP_A-1741895, SNP_A-1727343, SNP_A-1667938, SNP_A-1699779, SNP_A-2265485, SNP_A-1669899, SNP_A-1698723, SNP_A-2100560, SNP_A-1948487, SNP_A-1725232, SNP_A-1685936, SNP_A-8506674, SNP_A-1850808, SNP_A-1656069, SNP_A-1648118, SNP_A-1685580, SNP_A-1831715, SNP_A-1944780, SNP_A-4212106, SNP_A-2022921, SNP_A-1794809, SNP_A-1936106, SNP_A-2251710, SNP_A-2278912, SNP_A-2126978, SNP_A-2280956, SNP_A-2105871, SNP_A-2236653, SNP_A-2078944, SNP_A-1743601, SNP_A-1711074, SNP_A-1757991, SNP_A-1708336, SNP_A-1691218, SNP_A-1685004, SNP_A-4222994, SNP_A-2050561, SNP_A-1742053, SNP_A-2311141,

SNP_A-8535822, SNP_A-2272562, SNP_A-1668476, SNP_A-1650200, SNP_A-1753067, SNP_A-1711226, SNP_A-1684198, SNP_A-1722886, SNP_A-1701155, SNP_A-1988490, SNP_A-2301662, SNP_A-1859100, SNP_A-1714969, SNP_A-1744953, SNP_A-1712555, SNP_A-1734058, SNP_A-1742739, SNP_A-1646686, SNP_A-4281498, SNP_A-2059688, SNP_A-1643679, SNP_A-1692675, SNP_A-1745207, SNP_A-1683537, SNP_A-1899581, SNP_A-1746333, SNP_A-2306129, SNP_A-2099121, SNP_A-4218315, SNP_A-1901868, SNP_A-1729805, SNP_A-1662465, SNP_A-1665695, SNP_A-1694775, SNP_A-1743824, SNP_A-1751054, SNP_A-1726888, SNP_A-1757877, SNP_A-1726933, SNP_A-2012315, SNP_A-2114223, SNP_A-2135401, SNP_A-4266109, SNP_A-1721260, SNP_A-8539824, SNP_A-8439312, SNP_A-2182558, SNP_A-1733255, SNP_A-1665883, SNP_A-1678414, SNP_A-1724159, SNP_A-4283560, SNP_A-2198814, SNP_A-2155782, SNP_A-2226790, SNP_A-1653557, SNP_A-1655805, SNP_A-1647507, SNP_A-1804711, SNP_A-1703202, SNP_A-1753756, SNP_A-1693316, SNP_A-1732550, SNP_A-4279994, SNP_A-4240505, SNP_A-2224980, SNP_A-1852388, SNP_A-2184053, SNP_A-2099272, SNP_A-2298382, SNP_A-2207332, SNP_A-1906265, SNP_A-2174071, SNP_A-2037189, SNP_A-1933052, SNP_A-8405428, SNP_A-2082762, SNP_A-1790893, SNP_A-2040687, SNP_A-2093556, SNP_A-1894780, SNP_A-4229406, SNP_A-2037665, SNP_A-2232684, SNP_A-1802051, SNP_A-1934003, SNP_A-2215692, SNP_A-1988661, SNP_A-1817407, SNP_A-1752039, SNP_A-1734268, SNP_A-1657572, SNP_A-1667308, SNP_A-1711993, SNP_A-1691336, SNP_A-1861297, SNP_A-1818925, SNP_A-1935106, SNP_A-2219459, SNP_A-8678719, SNP_A-1935473, SNP_A-8603709, SNP_A-1731400, SNP_A-1658671, SNP_A-1711409, SNP_A-1720522, SNP_A-1656746, SNP_A-8381356, SNP_A-1748697, SNP_A-1694971, SNP_A-1738385, SNP_A-1725600, SNP_A-1735088, SNP_A-1757845, SNP_A-1748655, SNP_A-1723722, SNP_A-1714296, SNP_A-1672486, SNP_A-1649926, SNP_A-1839826, SNP_A-4203639, SNP_A-1730496, SNP_A-1735930, SNP_A-1663213, SNP_A-1677097, SNP_A-1655518, SNP_A-2273385, SNP_A-1749750, SNP_A-1684811, SNP_A-1696581, SNP_A-1745623, SNP_A-1728375, SNP_A-1648396, SNP_A-1717235, SNP_A-1701683, SNP_A-1706791,

SNP_A-1852133, SNP_A-8354904, SNP_A-8481594, SNP_A-2249778, SNP_A-1989340, SNP_A-4198615, SNP_A-2175332, SNP_A-2132880, SNP_A-4266261, SNP_A-1723646, SNP_A-1738797, SNP_A-1733518, SNP_A-1652644, SNP_A-1751135, SNP_A-1683894, SNP_A-1723440, SNP_A-1735743, SNP_A-2182672, SNP_A-4203762, SNP_A-1669354, SNP_A-1716464, SNP_A-1722049, SNP_A-1729323, SNP_A-1666975, SNP_A-1709146, SNP_A-1719604, SNP_A-1705258, SNP_A-1668349, SNP_A-1720040, SNP_A-1750574, SNP_A-1654380, SNP_A-1708537, SNP_A-1728717, SNP_A-1669275, SNP_A-1756681, SNP_A-1678972, SNP_A-1711909, SNP_A-1708360, SNP_A-1655739, SNP_A-1678766, SNP_A-1657798, SNP_A-1690938, SNP_A-1714499, SNP_A-1648608, SNP_A-1731461, SNP_A-2191626, SNP_A-2093084, SNP_A-1652284, SNP_A-1675029, SNP_A-1675043, SNP_A-1708102, SNP_A-1717859, SNP_A-1704215, SNP_A-1739293, SNP_A-1750255, SNP_A-1658170, SNP_A-1659868, SNP_A-1656713, SNP_A-1680880, SNP_A-8304784, SNP_A-8485151, SNP_A-1691373, SNP_A-1698336, SNP_A-1679907, SNP_A-1692305, SNP_A-1739264, SNP_A-1744246, SNP_A-4212351, SNP_A-1695542, SNP_A-1701278, SNP_A-1744432, SNP_A-1745936, SNP_A-1657624, SNP_A-1723732, SNP_A-1652298, SNP_A-1669678, SNP_A-1680219, SNP_A-1748719, SNP_A-1644691, SNP_A-1713666, SNP_A-1699197, SNP_A-1892278, SNP_A-4212356, SNP_A-2050951, SNP_A-4216528, SNP_A-2257644, SNP_A-1663872, SNP_A-1652724, SNP_A-1695907, SNP_A-2041709, SNP_A-2234583, SNP_A-2182141, SNP_A-2090418, SNP_A-2012555, SNP_A-1905809, SNP_A-1900185, SNP_A-4229699, SNP_A-1989801, SNP_A-1786515, SNP_A-1823216, SNP_A-1704506, SNP_A-1661901, SNP_A-1730353, SNP_A-1656344, SNP_A-2284470, SNP_A-1846427, SNP_A-1756377, SNP_A-1673552, SNP_A-1731327, SNP_A-1755452, SNP_A-1745804, SNP_A-1780760, SNP_A-1952179, SNP_A-2176560, SNP_A-2044199, SNP_A-1715947, SNP_A-1731745, SNP_A-1665070, SNP_A-1745284, SNP_A-1665955, SNP_A-1716382, SNP_A-1648041, SNP_A-1703666, SNP_A-2135758, SNP_A-1645545, SNP_A-1665150, SNP_A-1700913, SNP_A-1659334, SNP_A-1727797, SNP_A-1819858, SNP_A-1755626, SNP_A-1742101, SNP_A-1662936, SNP_A-1711120, SNP_A-1672030, SNP_A-1945250,

SNP_A-4252465, SNP_A-4297192, SNP_A-1730685, SNP_A-1660885, SNP_A-1753895, SNP_A-1714871, SNP_A-1672754, SNP_A-1660377, SNP_A-1643033, SNP_A-1693563, SNP_A-1704614, SNP_A-1646556, SNP_A-1921244, SNP_A-1891352, SNP_A-1745851, SNP_A-1687771, SNP_A-1693125, SNP_A-1668709, SNP_A-1677324, SNP_A-1989928, SNP_A-1671953, SNP_A-1858079, SNP_A-1720079, SNP_A-1665922, SNP_A-1707274, SNP_A-1723634, SNP_A-1746855, SNP_A-1735070, SNP_A-2012599, SNP_A-4260134, SNP_A-1682521, SNP_A-1666383, SNP_A-1719018, SNP_A-4228676, SNP_A-1690074, SNP_A-1747534, SNP_A-2071784, SNP_A-1951942, SNP_A-1959144, SNP_A-1731300, SNP_A-1931935, SNP_A-1669492, SNP_A-1699763, SNP_A-1854071, SNP_A-1662147, SNP_A-1752271, SNP_A-1697245, SNP_A-4222430, SNP_A-4251211, SNP_A-4236336, SNP_A-2104918, SNP_A-2199649, SNP_A-1733275, SNP_A-1667777, SNP_A-1705083, SNP_A-1929325, SNP_A-2252531, SNP_A-4289596, SNP_A-1680490, SNP_A-1950742, SNP_A-8454840, SNP_A-4212394, SNP_A-2307296, SNP_A-1715735, SNP_A-1688825, SNP_A-1692676, SNP_A-1707872, SNP_A-1920080, SNP_A-2158027, SNP_A-1864517, SNP_A-2120187, SNP_A-4220616, SNP_A-1712836, SNP_A-1989988, SNP_A-1952822, SNP_A-2212413, SNP_A-1733237, SNP_A-2291453, SNP_A-2214778, SNP_A-1656324, SNP_A-1701033, SNP_A-8487875, SNP_A-2202119, SNP_A-8322420, SNP_A-2120438, SNP_A-1646204, SNP_A-1758297, SNP_A-1650790, SNP_A-2022175, SNP_A-1711400, SNP_A-1731679, SNP_A-1696540, SNP_A-1677597, SNP_A-8354466, SNP_A-1750191, SNP_A-4273287, SNP_A-4293028, SNP_A-1662727, SNP_A-4237155, SNP_A-2272468, SNP_A-4236711, SNP_A-2092846, SNP_A-1945822, SNP_A-1827669, SNP_A-1877225, SNP_A-8669724, SNP_A-8672373, SNP_A-2090785, SNP_A-8369954, SNP_A-1727637, SNP_A-1875983, SNP_A-2198939, SNP_A-1665247, SNP_A-4293303, SNP_A-1674061, SNP_A-1656697, SNP_A-1990025, SNP_A-1670704, SNP_A-1956721, SNP_A-2124888, SNP_A-2096689, SNP_A-1704848, SNP_A-2077493, SNP_A-1951810, SNP_A-2186745, SNP_A-2184693, SNP_A-2149123, SNP_A-1857820, SNP_A-1858707, SNP_A-1928723, SNP_A-4266388, SNP_A-2090577, SNP_A-1958297, SNP_A-1697230, SNP_A-2139373, SNP_A-2143171,

SNP_A-1824636, SNP_A-1990039, SNP_A-2102801, SNP_A-1863418, SNP_A-2072097, SNP_A-1941251, SNP_A-2157281, SNP_A-2146465, SNP_A-2103135, SNP_A-2031401, SNP_A-4227637, SNP_A-2142316, SNP_A-1990058, SNP_A-2115750, SNP_A-2056336, SNP_A-1990073, SNP_A-1868726, SNP_A-2279925, SNP_A-1951268, SNP_A-1655250, SNP_A-1674764, SNP_A-1676759, SNP_A-1683569, SNP_A-1685709, SNP_A-4218410, SNP_A-1794154, SNP_A-4215237, SNP_A-1667161, SNP_A-4220775, SNP_A-1681509, SNP_A-1732378, SNP_A-1665141, SNP_A-1990139, SNP_A-2181655, SNP_A-1698319, SNP_A-1721033, SNP_A-1731410, SNP_A-1670773, SNP_A-1741137, SNP_A-1727344, SNP_A-1664913, SNP_A-1700324, SNP_A-1710196, SNP_A-1719514, SNP_A-1655598, SNP_A-1663879, SNP_A-1692988, SNP_A-1699760, SNP_A-2223556, SNP_A-1844238, SNP_A-4235099, SNP_A-2083523, SNP_A-1675353, SNP_A-1655511, SNP_A-1757973, SNP_A-1990174, SNP_A-2023512, SNP_A-1990187, SNP_A-2152259, SNP_A-1694844, SNP_A-1709112, SNP_A-1743040, SNP_A-1882063, SNP_A-4298282, SNP_A-1753460, SNP_A-1755513, SNP_A-1681549, SNP_A-1949414, SNP_A-2200323, SNP_A-1740134, SNP_A-1674514, SNP_A-1725919, SNP_A-1990324, SNP_A-1721622, SNP_A-1700805, SNP_A-1647502, SNP_A-1666730, SNP_A-1724504, SNP_A-4201867, SNP_A-2177994, SNP_A-1897981, SNP_A-2240107, SNP_A-4194392, SNP_A-1990396, SNP_A-1990398, SNP_A-2289496, SNP_A-4294880, SNP_A-1680699, SNP_A-1725009, SNP_A-1732070, SNP_A-1690947, SNP_A-1751862, SNP_A-1684791, SNP_A-1686651, SNP_A-2152642, SNP_A-4212488, SNP_A-2230076, SNP_A-2086208, SNP_A-1990467, SNP_A-1958267, SNP_A-2145063, SNP_A-1948789, SNP_A-2231608, SNP_A-1932808, SNP_A-1718304, SNP_A-1655880, SNP_A-1661547, SNP_A-1706538, SNP_A-1715760, SNP_A-1646594, SNP_A-1677552, SNP_A-1745934, SNP_A-1661312, SNP_A-1673172, SNP_A-1826967, SNP_A-4212509, SNP_A-2215494, SNP_A-2078008, SNP_A-4298007, SNP_A-2191087, SNP_A-4300812, SNP_A-4240028, SNP_A-1645970, SNP_A-1696918, SNP_A-1695417, SNP_A-1732113, SNP_A-1702333, SNP_A-1745312, SNP_A-1990597, SNP_A-1696916, SNP_A-2187783, SNP_A-1694643, SNP_A-4215247, SNP_A-1694061, SNP_A-4212522, SNP_A-1990622,

SNP_A-1990625, SNP_A-2066932, SNP_A-1825442, SNP_A-2115651, SNP_A-2012727, SNP_A-1801924, SNP_A-1916829, SNP_A-2212265, SNP_A-1712814, SNP_A-1645729, SNP_A-1656580, SNP_A-1706658, SNP_A-1690038, SNP_A-1695320, SNP_A-1751148, SNP_A-1724059, SNP_A-1650999, SNP_A-1663293, SNP_A-1665251, SNP_A-1714083, SNP_A-1657268, SNP_A-1697433, SNP_A-1662406, SNP_A-1734918, SNP_A-1690133, SNP_A-1654923, SNP_A-1675531, SNP_A-1757545, SNP_A-1753795, SNP_A-1706659, SNP_A-4255637, SNP_A-2100932, SNP_A-8397273, SNP_A-1935821, SNP_A-4303358, SNP_A-8591302, SNP_A-2292454, SNP_A-2164689, SNP_A-4298962, SNP_A-1747083, SNP_A-1736043, SNP_A-2033595, SNP_A-1739263, SNP_A-1990744, SNP_A-1721353, SNP_A-1751019, SNP_A-1756228, SNP_A-1727367, SNP_A-2218749, SNP_A-2285987, SNP_A-1716173, SNP_A-1651472, SNP_A-1723124, SNP_A-1681382, SNP_A-1663975, SNP_A-1671031, SNP_A-1706436, SNP_A-1713715, SNP_A-1646647, SNP_A-1705894, SNP_A-1747684, SNP_A-1753116, SNP_A-1800120, SNP_A-1953659, SNP_A-1749393, SNP_A-1739587, SNP_A-1717381, SNP_A-1990899, SNP_A-1663156, SNP_A-1671296, SNP_A-1699573, SNP_A-1657059, SNP_A-1714793, SNP_A-1698773, SNP_A-2248686, SNP_A-1794178, SNP_A-2029040, SNP_A-1990946, SNP_A-1990948, SNP_A-1681953, SNP_A-1724315, SNP_A-1665427, SNP_A-1668856, SNP_A-1672347, SNP_A-1676143, SNP_A-1682541, SNP_A-1684515, SNP_A-1695094, SNP_A-1738836, SNP_A-1675306, SNP_A-1742890, SNP_A-1677641, SNP_A-1719538, SNP_A-1721735, SNP_A-2148921, SNP_A-1842321, SNP_A-1852884, SNP_A-1990973, SNP_A-2054811, SNP_A-2062247, SNP_A-1990974, SNP_A-2069463, SNP_A-1812106, SNP_A-2025238, SNP_A-2057797, SNP_A-2136860, SNP_A-8421338, SNP_A-4219920, SNP_A-1816918, SNP_A-2198659, SNP_A-2230799, SNP_A-1647056, SNP_A-1697078, SNP_A-1875645, SNP_A-1748735, SNP_A-1661155, SNP_A-2142458, SNP_A-1680976, SNP_A-1713037, SNP_A-1673239, SNP_A-1653039, SNP_A-1658329, SNP_A-4244803, SNP_A-1709210, SNP_A-1714385, SNP_A-1719904, SNP_A-1701354, SNP_A-1665811, SNP_A-4272206, SNP_A-1960545, SNP_A-2031021, SNP_A-4212619, SNP_A-1991087, SNP_A-1991088, SNP_A-4212621, SNP_A-1720228,

SNP_A-1698272, SNP_A-1701814, SNP_A-1712644, SNP_A-1643783, SNP_A-1650635, SNP_A-1745008, SNP_A-1753674, SNP_A-1684797, SNP_A-1688717, SNP_A-1724607, SNP_A-1662313, SNP_A-1670626, SNP_A-1654755, SNP_A-1723166, SNP_A-1750157, SNP_A-1712083, SNP_A-1743859, SNP_A-1752597, SNP_A-1694629, SNP_A-1733574, SNP_A-1662718, SNP_A-2279165, SNP_A-1991225, SNP_A-4230911, SNP_A-2202008, SNP_A-1821187, SNP_A-4236650, SNP_A-2012886, SNP_A-1816080, SNP_A-1914405, SNP_A-2121665, SNP_A-2159554, SNP_A-2297448, SNP_A-4301310, SNP_A-8425104, SNP_A-1834435, SNP_A-8549107, SNP_A-2297353, SNP_A-2276341, SNP_A-2034694, SNP_A-1883437, SNP_A-1865376, SNP_A-1662338, SNP_A-1662992, SNP_A-1661083, SNP_A-1734620, SNP_A-1658484, SNP_A-1683324, SNP_A-1718185, SNP_A-1648964, SNP_A-1706829, SNP_A-1758214, SNP_A-1661037, SNP_A-1751821, SNP_A-1670023, SNP_A-1711378, SNP_A-1673871, SNP_A-1684737, SNP_A-1739124, SNP_A-1808641, SNP_A-2212656, SNP_A-2147761, SNP_A-1991456, SNP_A-1812411, SNP_A-1847921, SNP_A-4252544, SNP_A-1956253, SNP_A-8422060, SNP_A-8516494, SNP_A-8494437, SNP_A-2236442, SNP_A-4257462, SNP_A-1867218, SNP_A-2083165, SNP_A-4228118, SNP_A-1878826, SNP_A-2182975, SNP_A-1991600, SNP_A-1935469, SNP_A-1991630, SNP_A-2056365, SNP_A-1991635, SNP_A-1719453, SNP_A-1741085, SNP_A-1732486, SNP_A-1698839, SNP_A-1658766, SNP_A-1660697, SNP_A-1745610, SNP_A-1710708, SNP_A-1708811, SNP_A-1722554, SNP_A-1756931, SNP_A-1653298, SNP_A-1741341, SNP_A-1659436, SNP_A-2023778, SNP_A-2199497, SNP_A-2026129, SNP_A-1641821, SNP_A-1723690, SNP_A-1680486, SNP_A-1756120, SNP_A-1703245, SNP_A-1707912, SNP_A-1681910, SNP_A-1687956, SNP_A-1698401, SNP_A-2202651, SNP_A-1883435, SNP_A-4249393, SNP_A-1818278, SNP_A-1811254, SNP_A-2194926, SNP_A-1784202, SNP_A-1899610, SNP_A-1736364, SNP_A-1737346, SNP_A-1754689, SNP_A-1644127, SNP_A-1750948, SNP_A-1757632, SNP_A-1738271, SNP_A-1750627, SNP_A-1653132, SNP_A-1735491, SNP_A-1721850, SNP_A-1703989, SNP_A-1721860, SNP_A-1701749, SNP_A-1754544, SNP_A-1714671, SNP_A-1751578, SNP_A-1689521, SNP_A-1696589, SNP_A-1889139,

SNP_A-1685900, SNP_A-1728811, SNP_A-1737321, SNP_A-1737737, SNP_A-1707643, SNP_A-1714663, SNP_A-1712848, SNP_A-1754556, SNP_A-2234683, SNP_A-2279310, SNP_A-2268877, SNP_A-1674211, SNP_A-4219305, SNP_A-1961456, SNP_A-8325516, SNP_A-1666777, SNP_A-1668752, SNP_A-1721917, SNP_A-1738100, SNP_A-1666898, SNP_A-1696909, SNP_A-2219768, SNP_A-1668155, SNP_A-4218120, SNP_A-4202475, SNP_A-1932500, SNP_A-2170597, SNP_A-2291357, SNP_A-1991874, SNP_A-2179773, SNP_A-4297467, SNP_A-4243910, SNP_A-2042708, SNP_A-2270148, SNP_A-8517133, SNP_A-2260478, SNP_A-1680361, SNP_A-1751856, SNP_A-1648077, SNP_A-1719870, SNP_A-1704816, SNP_A-1728514, SNP_A-1674698, SNP_A-1875174, SNP_A-2028682, SNP_A-1992172, SNP_A-1842388, SNP_A-2310766, SNP_A-2297430, SNP_A-4252271, SNP_A-8567771, SNP_A-1697560, SNP_A-1747988, SNP_A-1686291, SNP_A-1733761, SNP_A-1671437, SNP_A-1677043, SNP_A-1940108, SNP_A-4238298, SNP_A-2013201, SNP_A-2013202, SNP_A-4221580, SNP_A-1797122, SNP_A-2040716, SNP_A-4217309, SNP_A-1751924, SNP_A-1681635, SNP_A-1693744, SNP_A-1739392, SNP_A-1748118, SNP_A-1679465, SNP_A-1672915, SNP_A-1940142, SNP_A-1651801, SNP_A-1655480, SNP_A-1740692, SNP_A-1746165, SNP_A-1673909, SNP_A-1665835, SNP_A-1673033, SNP_A-1722613, SNP_A-1827611, SNP_A-2314211, SNP_A-2311977, SNP_A-4253715, SNP_A-2109814, SNP_A-1724835, SNP_A-1664373, SNP_A-1675146, SNP_A-1719002, SNP_A-1729793, SNP_A-1656914, SNP_A-1695476, SNP_A-8339571, SNP_A-2026785, SNP_A-2044441, SNP_A-2114884, SNP_A-1737103, SNP_A-1732151, SNP_A-1755904, SNP_A-1735170, SNP_A-2031501, SNP_A-1898968, SNP_A-2302216, SNP_A-2053466, SNP_A-4203661, SNP_A-1860103, SNP_A-2216591, SNP_A-2194785, SNP_A-1992722, SNP_A-8627896, SNP_A-2313035, SNP_A-8326991, SNP_A-2095660, SNP_A-2257668, SNP_A-1992835, SNP_A-1660864, SNP_A-1667643, SNP_A-1713439, SNP_A-1752022, SNP_A-1679855, SNP_A-2294971, SNP_A-8452434, SNP_A-8469451, SNP_A-1992892, SNP_A-4223097, SNP_A-1729417, SNP_A-1653177, SNP_A-1662115, SNP_A-1708886, SNP_A-1903022, SNP_A-1691319, SNP_A-2052324, SNP_A-1738670, SNP_A-1741820, SNP_A-1743948,

SNP_A-1750804, SNP_A-1653061, SNP_A-1658167, SNP_A-1697289, SNP_A-1993021, SNP_A-1756097, SNP_A-1695804, SNP_A-1701248, SNP_A-1704704, SNP_A-1757386, SNP_A-1690086, SNP_A-1697241, SNP_A-2165813, SNP_A-1879028, SNP_A-1755019, SNP_A-1736932, SNP_A-1680061, SNP_A-1701068, SNP_A-4222779, SNP_A-8364034, SNP_A-2151622, SNP_A-2293205, SNP_A-2052037, SNP_A-2189110, SNP_A-2036008, SNP_A-1722154, SNP_A-1677982, SNP_A-1718101, SNP_A-1662516, SNP_A-1727002, SNP_A-1660843, SNP_A-1676521, SNP_A-1701679, SNP_A-1680017, SNP_A-1736200, SNP_A-1664983, SNP_A-1670729, SNP_A-1677585, SNP_A-1741725, SNP_A-1680274, SNP_A-1668131, SNP_A-1669828, SNP_A-1646237, SNP_A-2197371, SNP_A-2276295, SNP_A-1655244, SNP_A-1800296, SNP_A-2131476, SNP_A-1993155, SNP_A-1705702, SNP_A-1726190, SNP_A-2116315, SNP_A-4206776, SNP_A-1993169, SNP_A-1993173, SNP_A-2236251, SNP_A-2194729, SNP_A-1993185, SNP_A-2306170, SNP_A-8553009, SNP_A-4234559, SNP_A-8283753, SNP_A-1837350, SNP_A-4218799, SNP_A-8472389, SNP_A-8514744, SNP_A-4266943, SNP_A-8283768, SNP_A-8588706, SNP_A-2290217, SNP_A-8364447, SNP_A-1707478, SNP_A-1712412, SNP_A-1717808, SNP_A-1649113, SNP_A-1712128, SNP_A-1650269, SNP_A-2133028, SNP_A-1888699, SNP_A-4288127, SNP_A-4231723, SNP_A-2268879, SNP_A-1786064, SNP_A-2013456, SNP_A-2196527, SNP_A-8370991, SNP_A-8688979, SNP_A-2285175, SNP_A-4281937, SNP_A-1902342, SNP_A-2255595, SNP_A-4266984, SNP_A-1754011, SNP_A-1648672, SNP_A-1694585, SNP_A-1663376, SNP_A-1731855, SNP_A-2057660, SNP_A-2068632, SNP_A-8477010, SNP_A-8434562, SNP_A-2147879, SNP_A-8297603, SNP_A-8622697, SNP_A-4223561, SNP_A-1846546, SNP_A-8523549, SNP_A-2194566, SNP_A-1832289, SNP_A-1807998, SNP_A-1993725, SNP_A-2161273, SNP_A-4194261, SNP_A-2145517, SNP_A-1899335, SNP_A-4228721, SNP_A-2084395, SNP_A-4238025, SNP_A-1993757, SNP_A-2026255, SNP_A-1710256, SNP_A-1645121, SNP_A-1698870, SNP_A-1642698, SNP_A-1666929, SNP_A-1723669, SNP_A-2309884, SNP_A-1841840, SNP_A-1711802, SNP_A-1753237, SNP_A-1694425, SNP_A-1755564, SNP_A-1643960, SNP_A-1993903, SNP_A-1668524, SNP_A-1647686,

SNP_A-1658454, SNP_A-8518178, SNP_A-8372986, SNP_A-2163227, SNP_A-1993963, SNP_A-8585953, SNP_A-8498813, SNP_A-8341038, SNP_A-8489418, SNP_A-4229544, SNP_A-4194194, SNP_A-2244933, SNP_A-1715877, SNP_A-1647036, SNP_A-1728099, SNP_A-1686914, SNP_A-1659364, SNP_A-1668841, SNP_A-1796570, SNP_A-1660653, SNP_A-8282949, SNP_A-8373536, SNP_A-1827717, SNP_A-8462631, SNP_A-1812906, SNP_A-4232184, SNP_A-2111534, SNP_A-2231809, SNP_A-8651371, SNP_A-8411343, SNP_A-8284188, SNP_A-4298211, SNP_A-8459023, SNP_A-1677670, SNP_A-1711258, SNP_A-1734212, SNP_A-1711158, SNP_A-1676676, SNP_A-1751629, SNP_A-1687066, SNP_A-1725882, SNP_A-1727539, SNP_A-1643101, SNP_A-1698159, SNP_A-1741851, SNP_A-2086074, SNP_A-2013649, SNP_A-8697323, SNP_A-4269942, SNP_A-1994401, SNP_A-1844869, SNP_A-4271750, SNP_A-1674835, SNP_A-1678756, SNP_A-1714260, SNP_A-1673432, SNP_A-1667820, SNP_A-1663592, SNP_A-1888317, SNP_A-1685903, SNP_A-1734937, SNP_A-1737040, SNP_A-1666079, SNP_A-4206860, SNP_A-1994550, SNP_A-2051893, SNP_A-2150783, SNP_A-1920359, SNP_A-2108480, SNP_A-2063686, SNP_A-2269049, SNP_A-2292759, SNP_A-2220852, SNP_A-1875634, SNP_A-4269947, SNP_A-2236809, SNP_A-1938792, SNP_A-1994651, SNP_A-1691083, SNP_A-1696745, SNP_A-1741950, SNP_A-1748752, SNP_A-1675128, SNP_A-1737634, SNP_A-1741048, SNP_A-1737773, SNP_A-1744654, SNP_A-1672457, SNP_A-1684669, SNP_A-1726751, SNP_A-1739072, SNP_A-1673631, SNP_A-1726263, SNP_A-1671399, SNP_A-1719062, SNP_A-1723217, SNP_A-1731454, SNP_A-2134989, SNP_A-1838830, SNP_A-1939501, SNP_A-1994719, SNP_A-4224553, SNP_A-1693746, SNP_A-1742770, SNP_A-1675120, SNP_A-4215373, SNP_A-1994749, SNP_A-2090572, SNP_A-1928975, SNP_A-1667557, SNP_A-4213184, SNP_A-1839213, SNP_A-4219294, SNP_A-2283836, SNP_A-4216931, SNP_A-2162868, SNP_A-1721265, SNP_A-1741681, SNP_A-1696860, SNP_A-1721670, SNP_A-1653356, SNP_A-1702651, SNP_A-1714791, SNP_A-1756967, SNP_A-1750811, SNP_A-1645138, SNP_A-4294975, SNP_A-1705794, SNP_A-1727796, SNP_A-1679600, SNP_A-1728005, SNP_A-1650329, SNP_A-1698988, SNP_A-1706410, SNP_A-1745817, SNP_A-1753522,

SNP_A-1994833, SNP_A-1657747, SNP_A-1701456, SNP_A-1650081, SNP_A-1690254, SNP_A-1691773, SNP_A-2066991, SNP_A-4235355, SNP_A-1745493, SNP_A-1677225, SNP_A-1709242, SNP_A-1752538, SNP_A-1651137, SNP_A-1703190, SNP_A-1755547, SNP_A-1643076, SNP_A-1686289, SNP_A-8459547, SNP_A-1679411, SNP_A-1727151, SNP_A-1732002, SNP_A-1673467, SNP_A-1724391, SNP_A-1726497, SNP_A-1731714, SNP_A-4207147, SNP_A-8689378, SNP_A-2196495, SNP_A-2104115, SNP_A-2050697, SNP_A-4168485, SNP_A-1995113, SNP_A-1792414, SNP_A-2013839, SNP_A-2097726, SNP_A-4241515, SNP_A-2056011, SNP_A-1995165, SNP_A-1995167, SNP_A-1929557, SNP_A-1846024, SNP_A-1908113, SNP_A-2013868, SNP_A-1896987, SNP_A-4267263, SNP_A-2013883, SNP_A-2189012, SNP_A-2135940, SNP_A-4224175, SNP_A-4207099, SNP_A-2312515, SNP_A-1821538, SNP_A-2281698, SNP_A-4302033, SNP_A-4213283, SNP_A-1647204, SNP_A-1741229, SNP_A-2251579, SNP_A-1699069, SNP_A-1731645, SNP_A-1696124, SNP_A-1659262, SNP_A-1815343, SNP_A-1670943, SNP_A-1926670, SNP_A-2192183, SNP_A-8548090, SNP_A-1678719, SNP_A-1661285, SNP_A-1669880, SNP_A-1713413, SNP_A-1724269, SNP_A-1660732, SNP_A-1705706, SNP_A-1714740, SNP_A-1646163, SNP_A-2191324, SNP_A-1925872, SNP_A-1708589, SNP_A-2228472, SNP_A-1717507, SNP_A-1674926, SNP_A-1736583, SNP_A-1713926, SNP_A-2306290, SNP_A-1667381, SNP_A-1673312, SNP_A-1734073, SNP_A-1794496, SNP_A-2223000, SNP_A-2290415, SNP_A-1720920, SNP_A-1695955, SNP_A-1689758, SNP_A-2082234, SNP_A-2056382, SNP_A-4237319, SNP_A-1909439, SNP_A-8413169, SNP_A-2076308, SNP_A-1780706, SNP_A-2026635, SNP_A-1708129, SNP_A-1642938, SNP_A-1807666, SNP_A-1645391, SNP_A-1670854, SNP_A-4284502, SNP_A-1757485, SNP_A-1746180, SNP_A-2060546, SNP_A-2059659, SNP_A-1696655, SNP_A-2046970, SNP_A-2247723, SNP_A-1705064, SNP_A-1750162, SNP_A-1953688, SNP_A-1833047, SNP_A-1995566, SNP_A-4225506, SNP_A-1695818, SNP_A-1684879, SNP_A-1735579, SNP_A-1675366, SNP_A-1684027, SNP_A-1725711, SNP_A-1659847, SNP_A-1681221, SNP_A-1733921, SNP_A-1742148, SNP_A-1749618, SNP_A-1685961, SNP_A-1676437, SNP_A-1729070, SNP_A-1664827,

SNP_A-2119834, SNP_A-2051555, SNP_A-1995658, SNP_A-8657686, SNP_A-1853335, SNP_A-1705054, SNP_A-1680929, SNP_A-1732975, SNP_A-4207092, SNP_A-1660548, SNP_A-1718584, SNP_A-1654774, SNP_A-2205940, SNP_A-1757166, SNP_A-1646941, SNP_A-1699234, SNP_A-2209642, SNP_A-4238938, SNP_A-2068223, SNP_A-2205223, SNP_A-2117072, SNP_A-1649519, SNP_A-2048676, SNP_A-2259217, SNP_A-1659096, SNP_A-2172773, SNP_A-2111314, SNP_A-1653148, SNP_A-1714729, SNP_A-1728773, SNP_A-1746044, SNP_A-1754910, SNP_A-1695175, SNP_A-1643206, SNP_A-1650421, SNP_A-1700820, SNP_A-1709416, SNP_A-1756578, SNP_A-1704084, SNP_A-1641900, SNP_A-1687393, SNP_A-1739870, SNP_A-1743030, SNP_A-1748408, SNP_A-1681709, SNP_A-1701202, SNP_A-1704576, SNP_A-1648051, SNP_A-1702208, SNP_A-1756265, SNP_A-1682395, SNP_A-1687247, SNP_A-1689321, SNP_A-1748114, SNP_A-1674346, SNP_A-1678037, SNP_A-1654865, SNP_A-1741775, SNP_A-1698677, SNP_A-1662098, SNP_A-1682499, SNP_A-1726967, SNP_A-1735934, SNP_A-1844548, SNP_A-1677493, SNP_A-1665960, SNP_A-1746050, SNP_A-1725852, SNP_A-2116480, SNP_A-2311941, SNP_A-2131975, SNP_A-1706465, SNP_A-1812747, SNP_A-1995872, SNP_A-2146204, SNP_A-1716217, SNP_A-1656162, SNP_A-1677247, SNP_A-1797956, SNP_A-1687916, SNP_A-1659856, SNP_A-2172728, SNP_A-1995879, SNP_A-2249333, SNP_A-1757323, SNP_A-1731263, SNP_A-1724832, SNP_A-1661437, SNP_A-1672005, SNP_A-1728290, SNP_A-1655106, SNP_A-1709914, SNP_A-1715288, SNP_A-1644507, SNP_A-1949290, SNP_A-1721901, SNP_A-1664743, SNP_A-2156081, SNP_A-1995932, SNP_A-1714556, SNP_A-1701226, SNP_A-1720546, SNP_A-1665431, SNP_A-1669046, SNP_A-1712674, SNP_A-1718010, SNP_A-1730783, SNP_A-1708871, SNP_A-1642671, SNP_A-2141077, SNP_A-1652250, SNP_A-1724425, SNP_A-1701852, SNP_A-1643659, SNP_A-1647357, SNP_A-2265088, SNP_A-2201263, SNP_A-1685035, SNP_A-1691811, SNP_A-1707177, SNP_A-1665243, SNP_A-1648909, SNP_A-1688162, SNP_A-1753544, SNP_A-1737441, SNP_A-1691531, SNP_A-1702290, SNP_A-1689096, SNP_A-1741448, SNP_A-1752536, SNP_A-1996016, SNP_A-1646135, SNP_A-1701868, SNP_A-2212185, SNP_A-1755951, SNP_A-1647323,

SNP_A-2183160, SNP_A-2073742, SNP_A-4249460, SNP_A-2090397, SNP_A-1711270, SNP_A-1692340, SNP_A-2014079, SNP_A-1750623, SNP_A-2307667, SNP_A-1735682, SNP_A-1689762, SNP_A-1736461, SNP_A-1703565, SNP_A-1682600, SNP_A-1669395, SNP_A-1753740, SNP_A-1695867, SNP_A-1650489, SNP_A-1693848, SNP_A-2043728, SNP_A-1712409, SNP_A-2112366, SNP_A-1644397, SNP_A-1699973, SNP_A-1717893, SNP_A-1746746, SNP_A-2261661, SNP_A-8419431, SNP_A-2103901, SNP_A-1788688, SNP_A-1691297, SNP_A-1699996, SNP_A-1690364, SNP_A-1735938, SNP_A-1745891, SNP_A-1751312, SNP_A-1740738, SNP_A-1678849, SNP_A-1733383, SNP_A-1659057, SNP_A-1687648, SNP_A-1750869, SNP_A-1758902, SNP_A-1662480, SNP_A-1702930, SNP_A-1738435, SNP_A-1684493, SNP_A-1703229, SNP_A-1746464, SNP_A-1669765, SNP_A-1665158, SNP_A-4230643, SNP_A-1665803, SNP_A-1729127, SNP_A-1742743, SNP_A-1709019, SNP_A-1698787, SNP_A-1661878, SNP_A-1748873, SNP_A-1644002, SNP_A-4237968, SNP_A-1663040, SNP_A-1693967, SNP_A-1662858, SNP_A-2308261, SNP_A-2271813, SNP_A-8639723, SNP_A-1724369, SNP_A-1726231, SNP_A-4201797, SNP_A-2069249, SNP_A-2185962, SNP_A-1748501, SNP_A-1720180, SNP_A-1658154, SNP_A-1654434, SNP_A-1740473, SNP_A-1689938, SNP_A-1736802, SNP_A-1742353, SNP_A-1668031, SNP_A-1678391, SNP_A-1996156, SNP_A-1662091, SNP_A-1816517, SNP_A-1674508, SNP_A-1789209, SNP_A-2042602, SNP_A-1666675, SNP_A-1714363, SNP_A-1854008, SNP_A-1725742, SNP_A-1697163, SNP_A-1696660, SNP_A-1706426, SNP_A-1715617, SNP_A-1650672, SNP_A-2099988, SNP_A-1678079, SNP_A-2096605, SNP_A-1955248, SNP_A-2014124, SNP_A-1953151, SNP_A-1690746, SNP_A-1732821, SNP_A-1874342, SNP_A-1996195, SNP_A-4257390, SNP_A-2231845, SNP_A-2313641, SNP_A-1780398, SNP_A-2238547, SNP_A-1996198, SNP_A-4260334, SNP_A-1654954, SNP_A-1664259, SNP_A-1662852, SNP_A-1818832, SNP_A-1956312, SNP_A-4270002, SNP_A-4302861, SNP_A-1842798, SNP_A-1782101, SNP_A-2076778, SNP_A-4296020, SNP_A-4213420, SNP_A-1712923, SNP_A-1830886, SNP_A-2041797, SNP_A-1900181, SNP_A-8491068, SNP_A-2039610, SNP_A-1846786, SNP_A-8384292, SNP_A-8592617, SNP_A-2032731,

SNP_A-4215414, SNP_A-2084612, SNP_A-1736064, SNP_A-1780608, SNP_A-1708103, SNP_A-4257605, SNP_A-1705734, SNP_A-1696541, SNP_A-1702196, SNP_A-1747246, SNP_A-1675881, SNP_A-1673761, SNP_A-1642262, SNP_A-1818680, SNP_A-2130261, SNP_A-1655684, SNP_A-1664547, SNP_A-2228702, SNP_A-1875262, SNP_A-4286259, SNP_A-1812345, SNP_A-2127563, SNP_A-2108225, SNP_A-2159895, SNP_A-2194795, SNP_A-4270004, SNP_A-2028533, SNP_A-2066135, SNP_A-2079387, SNP_A-2056910, SNP_A-2161096, SNP_A-1840233, SNP_A-2026266, SNP_A-2089121, SNP_A-1645003, SNP_A-1690480, SNP_A-1699414, SNP_A-1747848, SNP_A-1642548, SNP_A-2131972, SNP_A-2231030, SNP_A-1717532, SNP_A-1646891, SNP_A-1943883, SNP_A-1661972, SNP_A-1693720, SNP_A-2085917, SNP_A-1692638, SNP_A-4275635, SNP_A-1747149, SNP_A-1744545, SNP_A-2222663, SNP_A-1657183, SNP_A-4204662, SNP_A-1930816, SNP_A-1650584, SNP_A-1996316, SNP_A-4203806, SNP_A-1681872, SNP_A-1752918, SNP_A-1682429, SNP_A-1676322, SNP_A-1731638, SNP_A-1693583, SNP_A-1750547, SNP_A-2059260, SNP_A-1742021, SNP_A-1737907, SNP_A-1688259, SNP_A-1700577, SNP_A-1703774, SNP_A-1754529, SNP_A-1737636, SNP_A-1742608, SNP_A-1729983, SNP_A-1741828, SNP_A-2286294, SNP_A-1686299, SNP_A-1693107, SNP_A-1745619, SNP_A-1678967, SNP_A-1684051, SNP_A-2303217, SNP_A-1660690, SNP_A-1711459, SNP_A-1815095, SNP_A-1739856, SNP_A-1754167, SNP_A-1739680, SNP_A-2062562, SNP_A-1725231, SNP_A-1707862, SNP_A-1735555, SNP_A-1675010, SNP_A-1726213, SNP_A-8327611, SNP_A-1896857, SNP_A-2203081, SNP_A-1996424, SNP_A-1746778, SNP_A-1685063, SNP_A-1693514, SNP_A-1747854, SNP_A-1698657, SNP_A-1913629, SNP_A-1680819, SNP_A-1730472, SNP_A-1735746, SNP_A-1738890, SNP_A-1671407, SNP_A-1683925, SNP_A-1667599, SNP_A-1723983, SNP_A-4244298, SNP_A-4242883, SNP_A-1718460, SNP_A-2279224, SNP_A-1880274, SNP_A-1996476, SNP_A-8516889, SNP_A-1665455, SNP_A-1669478, SNP_A-4216606, SNP_A-2304674, SNP_A-1661831, SNP_A-1709767, SNP_A-1649111, SNP_A-2158822, SNP_A-1659405, SNP_A-1689749, SNP_A-1996490, SNP_A-4292246, SNP_A-4248677, SNP_A-2100053, SNP_A-1667421, SNP_A-1694435,

SNP_A-2212903, SNP_A-4207744, SNP_A-2180964, SNP_A-1901772, SNP_A-1710731, SNP_A-1723267, SNP_A-1693705, SNP_A-1716381, SNP_A-1651626, SNP_A-4267451, SNP_A-1661304, SNP_A-1748956, SNP_A-1641832, SNP_A-4247735, SNP_A-1673355, SNP_A-1722731, SNP_A-1716662, SNP_A-1699423, SNP_A-2021921, SNP_A-4227110, SNP_A-2038145, SNP_A-1757564, SNP_A-4303524, SNP_A-1651203, SNP_A-1663113, SNP_A-1706580, SNP_A-1714217, SNP_A-2086934, SNP_A-1699104, SNP_A-1949837, SNP_A-2076362, SNP_A-2110687, SNP_A-2252410, SNP_A-1645963, SNP_A-1757256, SNP_A-2119680, SNP_A-1695711, SNP_A-2216009, SNP_A-1684470, SNP_A-1643071, SNP_A-1705211, SNP_A-1702762, SNP_A-1698329, SNP_A-1670474, SNP_A-1752506, SNP_A-1743213, SNP_A-1756080, SNP_A-1695574, SNP_A-1701120, SNP_A-1696066, SNP_A-2143565, SNP_A-4267463, SNP_A-1745096, SNP_A-1671748, SNP_A-1748679, SNP_A-1719981, SNP_A-1706079, SNP_A-4259978, SNP_A-1719673, SNP_A-1857199, SNP_A-2062926, SNP_A-2071898, SNP_A-4267465, SNP_A-2185401, SNP_A-1751286, SNP_A-1729260, SNP_A-1692733, SNP_A-1850861, SNP_A-2100618, SNP_A-2253542, SNP_A-1878227, SNP_A-1683543, SNP_A-1896616, SNP_A-2314420, SNP_A-2140527, SNP_A-1737865, SNP_A-1677813, SNP_A-1717742, SNP_A-2223826, SNP_A-4267470, SNP_A-1694556, SNP_A-4218660, SNP_A-4219146, SNP_A-4217326, SNP_A-1730754, SNP_A-2069277, SNP_A-1845505, SNP_A-2270529, SNP_A-2152532, SNP_A-1673567, SNP_A-1675470, SNP_A-1679115, SNP_A-8282177, SNP_A-1785600, SNP_A-8703549, SNP_A-1865257, SNP_A-8317139, SNP_A-8555632, SNP_A-8642200, SNP_A-1913609, SNP_A-1882540, SNP_A-2114350, SNP_A-2058721, SNP_A-2123733, SNP_A-1702709, SNP_A-1734391, SNP_A-2120239, SNP_A-2044358, SNP_A-2157284, SNP_A-1996665, SNP_A-1880369, SNP_A-1905107, SNP_A-8536910, SNP_A-8523913, SNP_A-8464963, SNP_A-8282625, SNP_A-8541505, SNP_A-8488816, SNP_A-1663711, SNP_A-8496956, SNP_A-8549416, SNP_A-1678200, SNP_A-2014238, SNP_A-4240731, SNP_A-2044788, SNP_A-4280160, SNP_A-8651618, SNP_A-8674269, SNP_A-8539604, SNP_A-4225691, SNP_A-8715909, SNP_A-8360464, SNP_A-8703798, SNP_A-8609219, SNP_A-8686491, SNP_A-8486607,

SNP_A-8414468, SNP_A-8321638, SNP_A-1812761, SNP_A-2116261, SNP_A-1718910, SNP_A-4297380, SNP_A-1674989, SNP_A-1702090, SNP_A-2094410, SNP_A-1699859, SNP_A-2210017, SNP_A-1749575, SNP_A-4219605, SNP_A-4227266, SNP_A-1665500, SNP_A-1705022, SNP_A-1750424, SNP_A-2190345, SNP_A-1820570, SNP_A-2293213, SNP_A-1695082, SNP_A-1700489, SNP_A-1720544, SNP_A-2077592, SNP_A-2118460, SNP_A-1920222, SNP_A-1869890, SNP_A-4194853, SNP_A-1996717, SNP_A-2175620, SNP_A-1789269, SNP_A-1927266, SNP_A-2053900, SNP_A-2046288, SNP_A-2310161, SNP_A-1996724, SNP_A-1749704, SNP_A-1805349, SNP_A-2072835, SNP_A-1752828, SNP_A-1682191, SNP_A-1705274, SNP_A-1710430, SNP_A-1717644, SNP_A-1656176, SNP_A-1704590, SNP_A-1644245, SNP_A-4303197, SNP_A-1747392, SNP_A-1687165, SNP_A-1825552, SNP_A-1996823, SNP_A-1738622, SNP_A-1750318, SNP_A-1683667, SNP_A-1689079, SNP_A-1672161, SNP_A-2219968, SNP_A-1669318, SNP_A-1671623, SNP_A-1715450, SNP_A-1704230, SNP_A-1707686, SNP_A-1745747, SNP_A-1741906, SNP_A-1680145, SNP_A-1725961, SNP_A-1736302, SNP_A-1662127, SNP_A-1665545, SNP_A-1717726, SNP_A-1718402, SNP_A-1713759, SNP_A-1678073, SNP_A-1732200, SNP_A-1672089, SNP_A-1719020, SNP_A-1658799, SNP_A-1662669, SNP_A-1707817, SNP_A-1652834, SNP_A-1656589, SNP_A-1734826, SNP_A-1725510, SNP_A-1744561, SNP_A-1706155, SNP_A-1653252, SNP_A-1723310, SNP_A-1708832, SNP_A-1712736, SNP_A-1721118, SNP_A-1655458, SNP_A-1655520, SNP_A-1659165, SNP_A-1702842, SNP_A-1715162, SNP_A-1646615, SNP_A-1654500, SNP_A-1662957, SNP_A-1722571, SNP_A-1660324, SNP_A-1707694, SNP_A-1716320, SNP_A-1645619, SNP_A-1693754, SNP_A-1745957, SNP_A-1748376, SNP_A-1642448, SNP_A-1691335, SNP_A-1743686, SNP_A-1753836, SNP_A-1684827, SNP_A-1690682, SNP_A-1739326, SNP_A-1753196, SNP_A-1731636, SNP_A-1673815, SNP_A-1683971, SNP_A-1726459, SNP_A-1664495, SNP_A-1669820, SNP_A-1682733, SNP_A-1737016, SNP_A-1737410, SNP_A-1669836, SNP_A-1675500, SNP_A-1719412, SNP_A-1723303, SNP_A-1660726, SNP_A-1665981, SNP_A-1692837, SNP_A-1709518, SNP_A-1655294, SNP_A-1693265, SNP_A-1703830, SNP_A-1690812,

SNP_A-1887072, SNP_A-1725246, SNP_A-1735514, SNP_A-1754219, SNP_A-1696117, SNP_A-1661119, SNP_A-1738924, SNP_A-4297878, SNP_A-1667977, SNP_A-4285993, SNP_A-2293861, SNP_A-1812256, SNP_A-1755044, SNP_A-1914044, SNP_A-1832436, SNP_A-1674857, SNP_A-1695540, SNP_A-2190574, SNP_A-2292355, SNP_A-4232685, SNP_A-1663982, SNP_A-2076117, SNP_A-1740172, SNP_A-1641775, SNP_A-1685257, SNP_A-1734451, SNP_A-1677795, SNP_A-1684887, SNP_A-1682319, SNP_A-1730674, SNP_A-1662909, SNP_A-1684211, SNP_A-1737042, SNP_A-1672929, SNP_A-1739280, SNP_A-1673785, SNP_A-1835855, SNP_A-1807235, SNP_A-2039154, SNP_A-2242784, SNP_A-1718996, SNP_A-1648753, SNP_A-1650531, SNP_A-1701018, SNP_A-1754773, SNP_A-1668621, SNP_A-1759044, SNP_A-1732942, SNP_A-1751519, SNP_A-1677802, SNP_A-1757804, SNP_A-1722089, SNP_A-1651197, SNP_A-1702385, SNP_A-1735012, SNP_A-1648207, SNP_A-1690132, SNP_A-2144445, SNP_A-1651997, SNP_A-2314604, SNP_A-1653063, SNP_A-1643008, SNP_A-8635230, SNP_A-1693758, SNP_A-1697453, SNP_A-1700988, SNP_A-8492442, SNP_A-1803650, SNP_A-1785519, SNP_A-1997357, SNP_A-4304767, SNP_A-2121786, SNP_A-2211282, SNP_A-1681319, SNP_A-1690118, SNP_A-1734065, SNP_A-1884778, SNP_A-1744260, SNP_A-1928851, SNP_A-1697676, SNP_A-1699556, SNP_A-1751508, SNP_A-2208765, SNP_A-1662524, SNP_A-1706599, SNP_A-1735484, SNP_A-1643660, SNP_A-1675089, SNP_A-1707687, SNP_A-1704163, SNP_A-1701729, SNP_A-1683858, SNP_A-1679111, SNP_A-1728280, SNP_A-1735357, SNP_A-1669844, SNP_A-1716636, SNP_A-1663441, SNP_A-1937288, SNP_A-1828231, SNP_A-1664229, SNP_A-1951512, SNP_A-1710915, SNP_A-1720592, SNP_A-4249263, SNP_A-1725933, SNP_A-1658505, SNP_A-1650361, SNP_A-1655710, SNP_A-2073662, SNP_A-1997539, SNP_A-1693904, SNP_A-1699646, SNP_A-1719170, SNP_A-1730021, SNP_A-1657374, SNP_A-1664011, SNP_A-1709988, SNP_A-1718826, SNP_A-1651383, SNP_A-1656884, SNP_A-1710700, SNP_A-1754633, SNP_A-1694072, SNP_A-1749912, SNP_A-1740506, SNP_A-1752882, SNP_A-1672143, SNP_A-1668965, SNP_A-1684090, SNP_A-1724812, SNP_A-1743757, SNP_A-1846653, SNP_A-1714339, SNP_A-1647283, SNP_A-1652293,

SNP_A-2215164, SNP_A-1698300, SNP_A-1705050, SNP_A-1750542, SNP_A-1754098, SNP_A-1727114, SNP_A-1755784, SNP_A-1688224, SNP_A-1735823, SNP_A-1744833, SNP_A-1731673, SNP_A-1701043, SNP_A-2205903, SNP_A-1799431, SNP_A-2149757, SNP_A-4267677, SNP_A-1748238, SNP_A-1752036, SNP_A-1757038, SNP_A-1688107, SNP_A-2014478, SNP_A-1691485, SNP_A-2093507, SNP_A-2094086, SNP_A-1745665, SNP_A-1718071, SNP_A-1727675, SNP_A-1732875, SNP_A-1744924, SNP_A-1755492, SNP_A-1727711, SNP_A-1895176, SNP_A-1693206, SNP_A-1669175, SNP_A-1689691, SNP_A-1997736, SNP_A-4257067, SNP_A-1669213, SNP_A-1668875, SNP_A-2294389, SNP_A-1751079, SNP_A-1904175, SNP_A-1694065, SNP_A-1663319, SNP_A-1646745, SNP_A-1652083, SNP_A-1706260, SNP_A-1669024, SNP_A-1672639, SNP_A-1717946, SNP_A-1657543, SNP_A-1712044, SNP_A-2156608, SNP_A-1721380, SNP_A-4258075, SNP_A-4289886, SNP_A-2287444, SNP_A-1643236, SNP_A-1693778, SNP_A-1642256, SNP_A-1684389, SNP_A-1694978, SNP_A-1721471, SNP_A-1673573, SNP_A-1658907, SNP_A-1707568, SNP_A-1644149, SNP_A-1651501, SNP_A-1958879, SNP_A-2152770, SNP_A-2236074, SNP_A-2303983, SNP_A-1710845, SNP_A-1752560, SNP_A-1645187, SNP_A-1650747, SNP_A-1702824, SNP_A-1708899, SNP_A-1718241, SNP_A-1652530, SNP_A-1646854, SNP_A-4224684, SNP_A-1889337, SNP_A-4213646, SNP_A-1698434, SNP_A-1752362, SNP_A-1654966, SNP_A-1693894, SNP_A-1697355, SNP_A-1696473, SNP_A-1743472, SNP_A-1679849, SNP_A-1729129, SNP_A-1725367, SNP_A-1732853, SNP_A-1684467, SNP_A-1959451, SNP_A-1695212, SNP_A-1908828, SNP_A-2167167, SNP_A-4225324, SNP_A-4201641, SNP_A-1685577, SNP_A-1887030, SNP_A-1736440, SNP_A-1718037, SNP_A-1642959, SNP_A-2194724, SNP_A-4267733, SNP_A-4289563, SNP_A-4267734, SNP_A-1749683, SNP_A-2244882, SNP_A-1723369, SNP_A-1724842, SNP_A-1740372, SNP_A-1743624, SNP_A-1704407, SNP_A-1660275, SNP_A-1741212, SNP_A-1809561, SNP_A-4280111, SNP_A-2258810, SNP_A-4292500, SNP_A-4267740, SNP_A-2240641, SNP_A-2288695, SNP_A-2021516, SNP_A-1902628, SNP_A-1919287, SNP_A-4196806, SNP_A-2070915, SNP_A-1653355, SNP_A-2236890, SNP_A-1940748, SNP_A-1701384,

SNP_A-1661357, SNP_A-4270060, SNP_A-2237595, SNP_A-1654784, SNP_A-8426341, SNP_A-1699424, SNP_A-1749748, SNP_A-1864117, SNP_A-4244472, SNP_A-8636354, SNP_A-2243982, SNP_A-1717146, SNP_A-4193108, SNP_A-4213667, SNP_A-1647151, SNP_A-1648675, SNP_A-1886367, SNP_A-4220525, SNP_A-1751704, SNP_A-1886131, SNP_A-1755151, SNP_A-1998051, SNP_A-2029001, SNP_A-2124365, SNP_A-1738349, SNP_A-1728251, SNP_A-2265307, SNP_A-1877302, SNP_A-2286973, SNP_A-1686805, SNP_A-1694036, SNP_A-1756159, SNP_A-1693858, SNP_A-2205577, SNP_A-1836846, SNP_A-1730435, SNP_A-1668267, SNP_A-4259081, SNP_A-2199607, SNP_A-1913728, SNP_A-1744773, SNP_A-1695856, SNP_A-4207402, SNP_A-1905039, SNP_A-1740378, SNP_A-1685049, SNP_A-1758598, SNP_A-2283398, SNP_A-1692185, SNP_A-1819381, SNP_A-2215838, SNP_A-1887485, SNP_A-4193222, SNP_A-2174923, SNP_A-4252063, SNP_A-8614426, SNP_A-4276909, SNP_A-8435658, SNP_A-8694229, SNP_A-1887881, SNP_A-2282433, SNP_A-4294555, SNP_A-1900448, SNP_A-2156633, SNP_A-2058855, SNP_A-1707234, SNP_A-1672880, SNP_A-1680664, SNP_A-1735146, SNP_A-2106754, SNP_A-2307100, SNP_A-1991855, SNP_A-1757259, SNP_A-1823427, SNP_A-4224486, SNP_A-2078004, SNP_A-2110572, SNP_A-1855787, SNP_A-4233573, SNP_A-4290374, SNP_A-2150564, SNP_A-2176989, SNP_A-1842375, SNP_A-1725523, SNP_A-1754733, SNP_A-1743448, SNP_A-1797402, SNP_A-1677023, SNP_A-1992552, SNP_A-2087964, SNP_A-1645751, SNP_A-1689147, SNP_A-1699704, SNP_A-1752088, SNP_A-1686989, SNP_A-1695284, SNP_A-1740582, SNP_A-1675713, SNP_A-8628340, SNP_A-8513099, SNP_A-2063874, SNP_A-1952704, SNP_A-2054079, SNP_A-1915531, SNP_A-1940377, SNP_A-2155676, SNP_A-1689303, SNP_A-1699950, SNP_A-1705158, SNP_A-1657354, SNP_A-1661016, SNP_A-1709862, SNP_A-1716736, SNP_A-1718806, SNP_A-1654750, SNP_A-1690348, SNP_A-1747824, SNP_A-1717508, SNP_A-1659271, SNP_A-1704358, SNP_A-2093475, SNP_A-1694030, SNP_A-1751960, SNP_A-1686793, SNP_A-1692177, SNP_A-1835365, SNP_A-4247135, SNP_A-1735273, SNP_A-2241656, SNP_A-4221843, SNP_A-2094862, SNP_A-1690426, SNP_A-1735844, SNP_A-1746085, SNP_A-1730009, SNP_A-1738480,

SNP_A-1665849, SNP_A-1704390, SNP_A-2215782, SNP_A-1679521, SNP_A-1725419, SNP_A-1666621, SNP_A-1670212, SNP_A-1719078, SNP_A-1694006, SNP_A-1746113, SNP_A-1674073, SNP_A-1677979, SNP_A-1740744, SNP_A-2284822, SNP_A-4213345, SNP_A-2115864, SNP_A-1961274, SNP_A-1996671, SNP_A-1801837, SNP_A-1996672, SNP_A-4301722, SNP_A-1931908, SNP_A-2112231, SNP_A-8496548, SNP_A-8376893, SNP_A-4220232, SNP_A-8582211, SNP_A-8696763, SNP_A-1880393, SNP_A-2031860, SNP_A-8411329, SNP_A-2273859, SNP_A-2286570, SNP_A-1997184, SNP_A-2156843, SNP_A-1737044, SNP_A-1737949, SNP_A-1667321, SNP_A-2199669, SNP_A-1835771, SNP_A-1830008, SNP_A-2183004, SNP_A-4231706, SNP_A-1672967, SNP_A-1674914, SNP_A-1672367, SNP_A-1723417, SNP_A-1728802, SNP_A-1662977, SNP_A-1720556, SNP_A-8606228, SNP_A-4207392, SNP_A-4282621, SNP_A-1665693, SNP_A-1679843, SNP_A-1734185, SNP_A-1659745, SNP_A-1666747, SNP_A-1672001, SNP_A-1715566, SNP_A-1721226, SNP_A-1699794, SNP_A-1703278, SNP_A-1648317, SNP_A-1658013, SNP_A-4226048, SNP_A-4224042, SNP_A-1724635, SNP_A-1694484, SNP_A-1746634, SNP_A-1757502, SNP_A-1695766, SNP_A-1713793, SNP_A-1726471, SNP_A-1647249, SNP_A-1704502, SNP_A-1709800, SNP_A-1648787, SNP_A-1698786, SNP_A-1706088, SNP_A-1682629, SNP_A-1687893, SNP_A-1740208, SNP_A-1746918, SNP_A-1652661, SNP_A-1702994, SNP_A-1713661, SNP_A-1646973, SNP_A-1642487, SNP_A-1682940, SNP_A-1758939, SNP_A-1648762, SNP_A-1755634, SNP_A-1645524, SNP_A-1736024, SNP_A-1742956, SNP_A-1681019, SNP_A-1722785, SNP_A-1665683, SNP_A-1670899, SNP_A-1654076, SNP_A-1706516, SNP_A-1707907, SNP_A-1716360, SNP_A-1648181, SNP_A-1705218, SNP_A-2174376, SNP_A-1746137, SNP_A-1999715, SNP_A-2086472, SNP_A-2283682, SNP_A-8290587, SNP_A-4194262, SNP_A-2047650, SNP_A-4286419, SNP_A-1650824, SNP_A-1714028, SNP_A-1671398, SNP_A-1712767, SNP_A-1718739, SNP_A-1748375, SNP_A-1731190, SNP_A-1665785, SNP_A-1709492, SNP_A-1719900, SNP_A-1649395, SNP_A-1700020, SNP_A-1644363, SNP_A-1667273, SNP_A-1671081, SNP_A-1713000, SNP_A-1665203, SNP_A-1714087, SNP_A-2270400, SNP_A-1697095, SNP_A-1703176,

SNP_A-1757094, SNP_A-1693129, SNP_A-1752604, SNP_A-1662417, SNP_A-1715215, SNP_A-1645767, SNP_A-2309568, SNP_A-8333403, SNP_A-8568052, SNP_A-8298556, SNP_A-2164079, SNP_A-4260136, SNP_A-2083746, SNP_A-1802611, SNP_A-1734135, SNP_A-1695273, SNP_A-1687993, SNP_A-1740250, SNP_A-2265770, SNP_A-1885534, SNP_A-2035886, SNP_A-1690736, SNP_A-1836648, SNP_A-1933140, SNP_A-1741030, SNP_A-1859208, SNP_A-1738320, SNP_A-1674734, SNP_A-2098914, SNP_A-1660351, SNP_A-1743237, SNP_A-1675062, SNP_A-1685583, SNP_A-2037611, SNP_A-1650738, SNP_A-1713244, SNP_A-2136453, SNP_A-4204317, SNP_A-2130603, SNP_A-8413607, SNP_A-4218550, SNP_A-4229168, SNP_A-2104735, SNP_A-2109347, SNP_A-2150485, SNP_A-1710837, SNP_A-2044920, SNP_A-4272283, SNP_A-1693716, SNP_A-1744300, SNP_A-2153878, SNP_A-1943332, SNP_A-1686089, SNP_A-1745419, SNP_A-1697089, SNP_A-1943576, SNP_A-2194164, SNP_A-1794400, SNP_A-1872716, SNP_A-2063073, SNP_A-1900666, SNP_A-2143370, SNP_A-2303552, SNP_A-2286186, SNP_A-1898806, SNP_A-1841452, SNP_A-1845131, SNP_A-1945600, SNP_A-1880462, SNP_A-1700714, SNP_A-1642116, SNP_A-1689113, SNP_A-1689863, SNP_A-1711336, SNP_A-1758324, SNP_A-1737548, SNP_A-1673581, SNP_A-1678927, SNP_A-1737699, SNP_A-1733864, SNP_A-1697679, SNP_A-1758436, SNP_A-1715581, SNP_A-1706701, SNP_A-1734238, SNP_A-1713079, SNP_A-1661816, SNP_A-1687962, SNP_A-1669705, SNP_A-1665464, SNP_A-1733612, SNP_A-1757051, SNP_A-1683149, SNP_A-1688275, SNP_A-1735377, SNP_A-1670196, SNP_A-1706986, SNP_A-1648554, SNP_A-1684872, SNP_A-1731813, SNP_A-1697597, SNP_A-1740219, SNP_A-1698123, SNP_A-1690956, SNP_A-1717564, SNP_A-1918265, SNP_A-1730219, SNP_A-1671029, SNP_A-1649715, SNP_A-1658235, SNP_A-1706714, SNP_A-1717794, SNP_A-1648535, SNP_A-1655604, SNP_A-1673783, SNP_A-1729895, SNP_A-1736732, SNP_A-1673333, SNP_A-1716840, SNP_A-1654908, SNP_A-1666977, SNP_A-2290694, SNP_A-4268324, SNP_A-2001911, SNP_A-2239947, SNP_A-1671170, SNP_A-1687156, SNP_A-1688472, SNP_A-1681158, SNP_A-1845577, SNP_A-4223596, SNP_A-8367468, SNP_A-8513754, SNP_A-2257246, SNP_A-2261823, SNP_A-2265162,

SNP_A-2126155, SNP_A-1675078, SNP_A-1683511, SNP_A-1732653, SNP_A-1665033, SNP_A-1668641, SNP_A-1696941, SNP_A-1751046, SNP_A-1642142, SNP_A-1647627, SNP_A-1689125, SNP_A-1701586, SNP_A-1688707, SNP_A-1801007, SNP_A-1677473, SNP_A-2198642, SNP_A-1791653, SNP_A-1666923, SNP_A-1747124, SNP_A-1674934, SNP_A-1729287, SNP_A-4214175, SNP_A-1725081, SNP_A-1726049, SNP_A-1649477, SNP_A-2118158, SNP_A-2030391, SNP_A-1830359, SNP_A-1816036, SNP_A-2053558, SNP_A-1696573, SNP_A-1700343, SNP_A-1718268, SNP_A-1659689, SNP_A-1715338, SNP_A-4207042, SNP_A-4214220, SNP_A-1648679, SNP_A-1798791, SNP_A-2107194, SNP_A-1864822, SNP_A-1697974, SNP_A-2125669, SNP_A-1748530, SNP_A-4268479, SNP_A-1735772, SNP_A-1669988, SNP_A-1728120, SNP_A-1644951, SNP_A-1736610, SNP_A-2258016, SNP_A-2173492, SNP_A-2244118, SNP_A-1741978, SNP_A-1713150, SNP_A-1665773, SNP_A-1673013, SNP_A-1680157, SNP_A-1659909, SNP_A-1668868, SNP_A-1704210, SNP_A-1816078, SNP_A-4235610, SNP_A-2003222, SNP_A-4214265, SNP_A-2003252, SNP_A-1949189, SNP_A-4240871, SNP_A-1668013, SNP_A-1670585, SNP_A-1716042, SNP_A-1717806, SNP_A-1721569, SNP_A-1726631, SNP_A-1723316, SNP_A-1672180, SNP_A-2039535, SNP_A-1685734, SNP_A-1671284, SNP_A-1687373, SNP_A-2159597, SNP_A-1734501, SNP_A-1746596, SNP_A-1647103, SNP_A-1697085, SNP_A-1708089, SNP_A-1645811, SNP_A-1705280, SNP_A-1755829, SNP_A-2291637, SNP_A-1690570, SNP_A-1729753, SNP_A-1734121, SNP_A-1739470, SNP_A-2178333, SNP_A-8519025, SNP_A-1747584, SNP_A-2031093, SNP_A-1728002, SNP_A-1664019, SNP_A-8497094, SNP_A-1940745, SNP_A-2076854, SNP_A-8395670, SNP_A-8527007, SNP_A-8290177, SNP_A-1704363, SNP_A-2200276, SNP_A-1757944, SNP_A-1700544, SNP_A-1743429, SNP_A-1752883, SNP_A-2279052, SNP_A-4227006, SNP_A-2003720, SNP_A-4244780, SNP_A-1674009, SNP_A-1897116, SNP_A-1726727, SNP_A-2178906, SNP_A-2065025, SNP_A-1740098, SNP_A-1745022, SNP_A-4194701, SNP_A-4229643, SNP_A-2077682, SNP_A-2075168, SNP_A-1787662, SNP_A-1864264, SNP_A-1900945, SNP_A-2001332, SNP_A-1754930, SNP_A-1744055, SNP_A-1710125, SNP_A-1742615, SNP_A-1715161,

SNP_A-1888855, SNP_A-1722648, SNP_A-2170540, SNP_A-8415484, SNP_A-1675333, SNP_A-1740047, SNP_A-1752023, SNP_A-1758393, SNP_A-1901213, SNP_A-8432483, SNP_A-2003986, SNP_A-1961462, SNP_A-8288867, SNP_A-1915064, SNP_A-1754412, SNP_A-1755432, SNP_A-4286790, SNP_A-1660121, SNP_A-8288870, SNP_A-8566602, SNP_A-2046389, SNP_A-1852747, SNP_A-1741248, SNP_A-1744414, SNP_A-1748162, SNP_A-1753502, SNP_A-1757232, SNP_A-1718230, SNP_A-1656304, SNP_A-1659753, SNP_A-1661755, SNP_A-1709122, SNP_A-1644003, SNP_A-1687617, SNP_A-1696331, SNP_A-4253484, SNP_A-1740252, SNP_A-1745060, SNP_A-1678237, SNP_A-2004173, SNP_A-2004178, SNP_A-1691451, SNP_A-1705440, SNP_A-1745507, SNP_A-1749550, SNP_A-1697749, SNP_A-1649298, SNP_A-1755946, SNP_A-1757975, SNP_A-1722712, SNP_A-1713478, SNP_A-1705844, SNP_A-1661163, SNP_A-1750752, SNP_A-1754339, SNP_A-1756502, SNP_A-1690933, SNP_A-1684507, SNP_A-1732258, SNP_A-1737564, SNP_A-1744048, SNP_A-1720043, SNP_A-1747741, SNP_A-1690944, SNP_A-1710716, SNP_A-1682220, SNP_A-1725589, SNP_A-1748318, SNP_A-1757202, SNP_A-1694788, SNP_A-1695210, SNP_A-1696959, SNP_A-1742134, SNP_A-1673511, SNP_A-1685757, SNP_A-2294258, SNP_A-1739786, SNP_A-1684727, SNP_A-8332290, SNP_A-1720980, SNP_A-1729835, SNP_A-1702828, SNP_A-1744450, SNP_A-1748080, SNP_A-1648961, SNP_A-1650295, SNP_A-1678591, SNP_A-1728300, SNP_A-1675068, SNP_A-1722679, SNP_A-1729637, SNP_A-1712606, SNP_A-1716128, SNP_A-4272842, SNP_A-1871948, SNP_A-1708133, SNP_A-1733449, SNP_A-1671093, SNP_A-1718236, SNP_A-1664807, SNP_A-1719160, SNP_A-1724831, SNP_A-1655874, SNP_A-1713100, SNP_A-2005234, SNP_A-2233896, SNP_A-4201570, SNP_A-1791355, SNP_A-4214467, SNP_A-1935737, SNP_A-1728932, SNP_A-1661343, SNP_A-1666663, SNP_A-1712016, SNP_A-1722739, SNP_A-1726277, SNP_A-1883805, SNP_A-1676549, SNP_A-1685631, SNP_A-2185649, SNP_A-1661615, SNP_A-1717636, SNP_A-1698898, SNP_A-1647911, SNP_A-1705382, SNP_A-8556798, SNP_A-2078740, SNP_A-8683526, SNP_A-2112732, SNP_A-2023557, SNP_A-1802166, SNP_A-8521789, SNP_A-4239122, SNP_A-8334127, SNP_A-2269896, SNP_A-2309990,

SNP_A-2001519, SNP_A-2006237, SNP_A-2100920, SNP_A-2173712, SNP_A-2166547, SNP_A-2204538, SNP_A-8581503, SNP_A-2139668, SNP_A-1740605, SNP_A-1653182, SNP_A-1695121, SNP_A-1653638, SNP_A-1702981, SNP_A-1746987, SNP_A-1680064, SNP_A-1666184, SNP_A-1652621, SNP_A-1752458, SNP_A-1645245, SNP_A-1691955, SNP_A-1706112, SNP_A-8299248, SNP_A-4195666, SNP_A-8365080, SNP_A-8534689, SNP_A-1660838, SNP_A-1710024, SNP_A-1712012, SNP_A-1678534, SNP_A-1698776, SNP_A-1644032, SNP_A-1671608, SNP_A-1659438, SNP_A-1672560, SNP_A-1663312, SNP_A-1656223, SNP_A-1731543, SNP_A-4300197, SNP_A-1795194, SNP_A-4260942, SNP_A-1751224, SNP_A-1714063, SNP_A-1715167, SNP_A-1658687, SNP_A-1682350, SNP_A-1714644, SNP_A-1643811, SNP_A-1650953, SNP_A-1668348, SNP_A-1652639, SNP_A-1889948, SNP_A-1692867, SNP_A-2006783, SNP_A-1880749, SNP_A-1699168, SNP_A-1703733, SNP_A-1655642, SNP_A-1930010, SNP_A-1745906, SNP_A-2096098, SNP_A-8300213, SNP_A-2078668, SNP_A-2188173, SNP_A-1841926, SNP_A-1695098, SNP_A-1754573, SNP_A-4291712, SNP_A-1649540, SNP_A-1733458, SNP_A-4302062, SNP_A-1752733, SNP_A-1861793, SNP_A-1642499, SNP_A-1685192, SNP_A-2243779, SNP_A-1878356, SNP_A-1675997, SNP_A-1863349, SNP_A-2001636, SNP_A-2151748, SNP_A-2066655, SNP_A-2007042, SNP_A-2213893, SNP_A-2081233, SNP_A-1687444, SNP_A-1673649, SNP_A-2001647, SNP_A-2007214, SNP_A-8471173, SNP_A-4269135, SNP_A-1737070, SNP_A-1740478, SNP_A-1722501, SNP_A-1655384, SNP_A-8336664, SNP_A-8472433, SNP_A-1741152, SNP_A-1752134, SNP_A-1680035, SNP_A-1703362, SNP_A-1752584, SNP_A-1754589, SNP_A-1689329, SNP_A-1692693, SNP_A-8651405, SNP_A-8563209, SNP_A-2055118, SNP_A-2092675, SNP_A-2007599, SNP_A-4200001, SNP_A-1839459, SNP_A-1730544, SNP_A-8433400, SNP_A-1699006, SNP_A-1744296, SNP_A-1755209, SNP_A-1679309, SNP_A-1681179, SNP_A-1676859, SNP_A-1732895, SNP_A-1736450, SNP_A-1663461, SNP_A-1676009, SNP_A-1683157, SNP_A-1723239, SNP_A-1734999, SNP_A-1664497, SNP_A-1729481, SNP_A-1705306, SNP_A-1714145, SNP_A-1716140, SNP_A-8436719, SNP_A-2149468, SNP_A-2007849, SNP_A-1664283, SNP_A-1715172,

SNP_A-1720972, SNP_A-1652205, SNP_A-1649331, SNP_A-1657509, SNP_A-1666127, SNP_A-1713687, SNP_A-1755101, SNP_A-1657022, SNP_A-1668990, SNP_A-1720194, SNP_A-1756844, SNP_A-1653337, SNP_A-1695228, SNP_A-1699100, SNP_A-1705710, SNP_A-1652529, SNP_A-1695995, SNP_A-1744606, SNP_A-1745133, SNP_A-1753758, SNP_A-1645001, SNP_A-1737546, SNP_A-1747736, SNP_A-4290284, SNP_A-1680609, SNP_A-8428116, SNP_A-8334829, SNP_A-1900853, SNP_A-2050422, SNP_A-2306099, SNP_A-1788163, SNP_A-2008213, SNP_A-1808480, SNP_A-1866310, SNP_A-2045823, SNP_A-2027811, SNP_A-2284136, SNP_A-2001788, SNP_A-1717284, SNP_A-1724485, SNP_A-1648331, SNP_A-1659013, SNP_A-1908577, SNP_A-1702308, SNP_A-1714990, SNP_A-1731096, SNP_A-4269290, SNP_A-1905454, SNP_A-2199367, SNP_A-4298850, SNP_A-1892776, SNP_A-1746124, SNP_A-2150398, SNP_A-1702275, SNP_A-2243830, SNP_A-2312786, SNP_A-4214786, SNP_A-2258230, SNP_A-1717448, SNP_A-1646999, SNP_A-1654090, SNP_A-1700776, SNP_A-1858640, SNP_A-1735665, SNP_A-1749574, SNP_A-1687773, SNP_A-1693388, SNP_A-1741908, SNP_A-1750740, SNP_A-1743150, SNP_A-1683289, SNP_A-1730456, SNP_A-1735736, SNP_A-1660108, SNP_A-1668780, SNP_A-4200113, SNP_A-2009225, SNP_A-2309960, SNP_A-2061877, SNP_A-2297824, SNP_A-2009268, SNP_A-1701021, SNP_A-1722530, SNP_A-1695739, SNP_A-1736747, SNP_A-1746911, SNP_A-1892129, SNP_A-2259254, SNP_A-4276329, SNP_A-1813459, SNP_A-1815514, SNP_A-2062954, SNP_A-4230856, SNP_A-2273982, SNP_A-4193588, SNP_A-2086205, SNP_A-1739151, SNP_A-4232160, SNP_A-1717779, SNP_A-2009748, SNP_A-1723082, SNP_A-1753475, SNP_A-2208548, SNP_A-4226115, SNP_A-2207811, SNP_A-1955172, SNP_A-1796374, SNP_A-1643388, SNP_A-1701158, SNP_A-1709820, SNP_A-1727338, SNP_A-1659823, SNP_A-1658959, SNP_A-1660408, SNP_A-1691123, SNP_A-1658981, SNP_A-1664145, SNP_A-1667717, SNP_A-2232065, SNP_A-1665169, SNP_A-1705436, SNP_A-1654598, SNP_A-4269539, SNP_A-1710136, SNP_A-1870333, SNP_A-1693422, SNP_A-1700727, SNP_A-1746055, SNP_A-1751406, SNP_A-1658647, SNP_A-1665377, SNP_A-1718650, SNP_A-1725855, SNP_A-1707146, SNP_A-1713991, SNP_A-1717738,

SNP_A-1647367, SNP_A-1655552, SNP_A-1957837, SNP_A-1704426, SNP_A-1753992, SNP_A-1685427, SNP_A-1694058, SNP_A-1646707, SNP_A-1643118, SNP_A-1645259, SNP_A-1650487, SNP_A-1701364, SNP_A-1703918, SNP_A-1695694, SNP_A-2241622, SNP_A-2148416, SNP_A-1726715, SNP_A-1902049, SNP_A-1679857, SNP_A-2125241, SNP_A-1679666, SNP_A-1729266, SNP_A-1645880, SNP_A-1677680, SNP_A-1650720, SNP_A-1729265, SNP_A-8701903, SNP_A-1746726, SNP_A-1683079, SNP_A-1939085, SNP_A-1877953, SNP_A-1681170, SNP_A-1687317, SNP_A-2010799, SNP_A-2054107, SNP_A-1738576, SNP_A-1956307, SNP_A-1674464, SNP_A-2314972, SNP_A-1842829, SNP_A-4269596, SNP_A-1805415, SNP_A-4207458, SNP_A-2128547, SNP_A-2010975, SNP_A-2237882, SNP_A-1897021, SNP_A-2155507, SNP_A-1709380, SNP_A-1756221, SNP_A-1643971, SNP_A-1697880, SNP_A-1782562, SNP_A-2038289, SNP_A-1657777, SNP_A-1814403, SNP_A-2234258, SNP_A-2138158, SNP_A-1722254, SNP_A-8614886, SNP_A-8440401, SNP_A-1735639, SNP_A-2041992, SNP_A-1646156, SNP_A-1713800, SNP_A-1704907, SNP_A-1701584, SNP_A-1756033, SNP_A-1686861, SNP_A-1692121, SNP_A-1697520, SNP_A-1713587, SNP_A-1697650, SNP_A-1683493, SNP_A-1739468, SNP_A-1744542, SNP_A-1646821, SNP_A-1658985, SNP_A-1709184, SNP_A-1642110, SNP_A-1749414, SNP_A-1682887, SNP_A-1706168, SNP_A-2197268, SNP_A-2123098, SNP_A-4282025, SNP_A-1854249, SNP_A-1789006, SNP_A-2214515, SNP_A-2234594, SNP_A-4219245, SNP_A-2075344, SNP_A-4216625, SNP_A-2291812, SNP_A-1662971, SNP_A-1669044, SNP_A-1688719, SNP_A-2258670, SNP_A-1943854, SNP_A-1747840, SNP_A-1675607, SNP_A-1733625, SNP_A-1743668, SNP_A-2215006, SNP_A-2116875, SNP_A-8460829, SNP_A-1756962, SNP_A-1691793, SNP_A-1732132, SNP_A-1669964, SNP_A-2114330, SNP_A-1646513, SNP_A-1688175, SNP_A-4246981, SNP_A-1721330, SNP_A-1707961, SNP_A-2040451, SNP_A-1696167, SNP_A-1752112, SNP_A-1940620, SNP_A-1751138, SNP_A-1688907, SNP_A-1875050, SNP_A-1656934, SNP_A-1647553, SNP_A-2253724, SNP_A-1683963, SNP_A-1703510, SNP_A-8638520, SNP_A-8658432, SNP_A-4260235, SNP_A-2069966, SNP_A-4244727, SNP_A-1689982, SNP_A-1666833, SNP_A-1673557,

SNP_A-2002011, SNP_A-1688913, SNP_A-1861915, SNP_A-1700888, SNP_A-1741284, SNP_A-1749732, SNP_A-1738462, SNP_A-1737530, SNP_A-2178708, SNP_A-4226375, SNP_A-4206057, SNP_A-2304936, SNP_A-1737845, SNP_A-1665343, SNP_A-4254427, SNP_A-1836344, SNP_A-2191118, SNP_A-4296960, SNP_A-1659309, SNP_A-4275540, SNP_A-2231367, SNP_A-1706518, SNP_A-4238239, SNP_A-4215155, SNP_A-1742844, SNP_A-2051146, SNP_A-1686501, SNP_A-1664621, SNP_A-2276579, SNP_A-1711637, SNP_A-1649499, SNP_A-1672717, SNP_A-4269740, SNP_A-1715276, SNP_A-1721024, SNP_A-1707244, SNP_A-1817208, SNP_A-4198061, SNP_A-1898557, SNP_A-2012072, SNP_A-2113250, SNP_A-2171506, SNP_A-1943806, SNP_A-2101232, SNP_A-2036668, SNP_A-2274212, SNP_A-1875364, SNP_A-2133255, SNP_A-2240274, SNP_A-2271177, SNP_A-2157075, SNP_A-1961164, SNP_A-4223028, SNP_A-2175742, SNP_A-1707662, SNP_A-1704646, SNP_A-1712184, SNP_A-2050322, SNP_A-4235104, SNP_A-1752298, SNP_A-1757586, SNP_A-2301794, SNP_A-8322534, SNP_A-1798736, SNP_A-4231951, SNP_A-4215218, SNP_A-2080659, SNP_A-4227653, SNP_A-2106459, SNP_A-2194981, SNP_A-1645839, SNP_A-1656554, SNP_A-1707226, SNP_A-1688597, SNP_A-1701240, SNP_A-1717536, SNP_A-2228398, SNP_A-4226483, SNP_A-1682032, SNP_A-1657646, SNP_A-1687872, SNP_A-1655851, SNP_A-1657155, SNP_A-8645859, SNP_A-8388180, SNP_A-4236267, SNP_A-8660455, SNP_A-1875792, SNP_A-2014061, SNP_A-2146044, SNP_A-1877865, SNP_A-2201883, SNP_A-1685432, SNP_A-1727118, SNP_A-1749237, SNP_A-1684900, SNP_A-1705399, SNP_A-2181881, SNP_A-2205730, SNP_A-4215444, SNP_A-1699842, SNP_A-1754000, SNP_A-1697297, SNP_A-1741584, SNP_A-8544448, SNP_A-2224845, SNP_A-4243781, SNP_A-8676373, SNP_A-2014769, SNP_A-8408874, SNP_A-1951849, SNP_A-2224764, SNP_A-4217700, SNP_A-1736388, SNP_A-1738694, SNP_A-1743050, SNP_A-1750544, SNP_A-1681571, SNP_A-1715096, SNP_A-1644321, SNP_A-1654902, SNP_A-2222044, SNP_A-2139945, SNP_A-1890873, SNP_A-2063862, SNP_A-1957825, SNP_A-2265710, SNP_A-2016997, SNP_A-1716058, SNP_A-1742110, SNP_A-4215783, SNP_A-1746139, SNP_A-1753070, SNP_A-1679145, SNP_A-2017559, SNP_A-2183343,

SNP_A-2176709, SNP_A-1671173, SNP_A-1676401, SNP_A-4248252, SNP_A-8531302, SNP_A-2130392, SNP_A-1907225, SNP_A-1840652, SNP_A-4302747, SNP_A-8356780, SNP_A-4253189, SNP_A-1811523, SNP_A-4252234, SNP_A-4236382, SNP_A-1887751, SNP_A-2256031, SNP_A-1689334, SNP_A-1660349, SNP_A-1670313, SNP_A-1691379, SNP_A-1737364, SNP_A-1675322, SNP_A-1808856, SNP_A-2165055, SNP_A-1701806, SNP_A-1710492, SNP_A-1712414, SNP_A-2102399, SNP_A-1651993, SNP_A-1851069, SNP_A-2303462, SNP_A-1724587, SNP_A-1795525, SNP_A-2041439, SNP_A-1693976, SNP_A-2208856, SNP_A-1789060, SNP_A-1742118, SNP_A-1678643, SNP_A-1737863, SNP_A-2230045, SNP_A-1728496, SNP_A-1814373, SNP_A-2280211, SNP_A-2234194, SNP_A-4222056, SNP_A-1681647, SNP_A-1655978, SNP_A-1662505, SNP_A-1708287, SNP_A-1702302, SNP_A-1643985, SNP_A-1727950, SNP_A-1667076, SNP_A-1646314, SNP_A-1732413, SNP_A-2021247, SNP_A-2101929, SNP_A-1656941, SNP_A-1690723, SNP_A-1693244, SNP_A-1690667, SNP_A-1660995, SNP_A-1703069, SNP_A-1741088, SNP_A-1710471, SNP_A-1698525, SNP_A-1731956, SNP_A-1741980, SNP_A-1758091, SNP_A-1736107, SNP_A-1724314, SNP_A-1750799, SNP_A-1727899, SNP_A-1727717, SNP_A-1675986, SNP_A-1658882, SNP_A-1749749, SNP_A-1679167, SNP_A-1728746, SNP_A-1737292, SNP_A-1666493, SNP_A-1676783, SNP_A-1703590, SNP_A-1643362, SNP_A-1688811, SNP_A-1748849, SNP_A-1742684, SNP_A-1748196, SNP_A-1657570, SNP_A-1653668, SNP_A-1674869, SNP_A-1729224, SNP_A-1642247, SNP_A-1740314, SNP_A-1722153, SNP_A-2059971, SNP_A-1744688, SNP_A-1669370, SNP_A-8519878, SNP_A-1741458, SNP_A-1753866, SNP_A-2057515, SNP_A-2272062, SNP_A-1686621, SNP_A-1732775, SNP_A-1738338, SNP_A-1741804, SNP_A-1727334, SNP_A-1732434, SNP_A-8518150, SNP_A-2002417, SNP_A-1855519, SNP_A-2268988, SNP_A-2198394, SNP_A-4280241, SNP_A-1788476, SNP_A-1662948, SNP_A-1651518, SNP_A-1704061, SNP_A-2070639, SNP_A-4204830, SNP_A-1683552, SNP_A-1686952, SNP_A-1682795, SNP_A-1735401, SNP_A-2261213, SNP_A-1676901, SNP_A-1681861, SNP_A-1750641, SNP_A-1714220, SNP_A-1674328, SNP_A-1653274, SNP_A-2147832, SNP_A-1719888, SNP_A-1726775,

SNP_A-2303655, SNP_A-4229927, SNP_A-4214186, SNP_A-1786474, SNP_A-8434276, SNP_A-1647812, SNP_A-2079609, SNP_A-1848098, SNP_A-1669702, SNP_A-2028803, SNP_A-1652659, SNP_A-1825551, SNP_A-1704067, SNP_A-1700436, SNP_A-1677732, SNP_A-1663469, SNP_A-1687068, SNP_A-1735913, SNP_A-1699473, SNP_A-1725287, SNP_A-1727225, SNP_A-1712054, SNP_A-1720872, SNP_A-1651883, SNP_A-1854576, SNP_A-1702496, SNP_A-1645879, SNP_A-1649083, SNP_A-2129573, SNP_A-2306676, SNP_A-2225104, SNP_A-4231318, SNP_A-2206586, SNP_A-2243728, SNP_A-1807996, SNP_A-1907059, SNP_A-1936708, SNP_A-2259243, SNP_A-2238996, SNP_A-2292104, SNP_A-2291359, SNP_A-1851832, SNP_A-1806490, SNP_A-4194042, SNP_A-1669438, SNP_A-1706668, SNP_A-1644621, SNP_A-1650025, SNP_A-1698464, SNP_A-1700709, SNP_A-1705836, SNP_A-2028276, SNP_A-1820024, SNP_A-1750630, SNP_A-1681969, SNP_A-1666957, SNP_A-1673809, SNP_A-1682805, SNP_A-1731886, SNP_A-4293010, SNP_A-4255820, SNP_A-1725220, SNP_A-1942689, SNP_A-1733340, SNP_A-1642455, SNP_A-2293258, SNP_A-1664350, SNP_A-1680736, SNP_A-4243111, SNP_A-1740908, SNP_A-1726511, SNP_A-1684692, SNP_A-1708394, SNP_A-1720870, SNP_A-1742553, SNP_A-1732649, SNP_A-1712882, SNP_A-4274322, SNP_A-2260696, SNP_A-2092848, SNP_A-4217006, SNP_A-4299235, SNP_A-4290689, SNP_A-2051312, SNP_A-2002530, SNP_A-1920115, SNP_A-2032447, SNP_A-4272185, SNP_A-2302204, SNP_A-4259590, SNP_A-4276753, SNP_A-2246369, SNP_A-8352613, SNP_A-4272261, SNP_A-4301905, SNP_A-1957628, SNP_A-4274312, SNP_A-2214350, SNP_A-2265834, SNP_A-1730725, SNP_A-1714935, SNP_A-1646082, SNP_A-1700765, SNP_A-1698491, SNP_A-1747709, SNP_A-1751619, SNP_A-1693477, SNP_A-1681532, SNP_A-1744165, SNP_A-1758944, SNP_A-4259107, SNP_A-1789469, SNP_A-2171848, SNP_A-8289818, SNP_A-4272834, SNP_A-8599058, SNP_A-1728416, SNP_A-1649489, SNP_A-8683803, SNP_A-1658207, SNP_A-1706676, SNP_A-1643048, SNP_A-1669780, SNP_A-1724507, SNP_A-1665439, SNP_A-1723475, SNP_A-1662917, SNP_A-1670042, SNP_A-1708505, SNP_A-1840301, SNP_A-1653503, SNP_A-4273033, SNP_A-2031032, SNP_A-2100316, SNP_A-4193179, SNP_A-4199203,

SNP_A-2084703, SNP_A-2135435, SNP_A-2002597, SNP_A-1721003, SNP_A-1749495, SNP_A-1758572, SNP_A-1730569, SNP_A-1724448, SNP_A-1880561, SNP_A-1684738, SNP_A-1736095, SNP_A-2031713, SNP_A-1729098, SNP_A-1656331, SNP_A-1667084, SNP_A-1650468, SNP_A-1668226, SNP_A-1870219, SNP_A-2188260, SNP_A-4285322, SNP_A-2050405, SNP_A-2262887, SNP_A-2223938, SNP_A-1751371, SNP_A-1678270, SNP_A-1727771, SNP_A-1668825, SNP_A-1739981, SNP_A-1648874, SNP_A-1857075, SNP_A-2042849, SNP_A-2037950, SNP_A-1725218, SNP_A-1693859, SNP_A-1696480, SNP_A-1746929, SNP_A-1737720, SNP_A-2119457, SNP_A-1676693, SNP_A-1685203, SNP_A-1729493, SNP_A-1733043, SNP_A-1739550, SNP_A-1667441, SNP_A-1677929, SNP_A-1726087, SNP_A-1785937, SNP_A-2252377, SNP_A-1668075, SNP_A-2239290, SNP_A-1712904, SNP_A-1742678, SNP_A-1658501, SNP_A-1710725, SNP_A-1647567, SNP_A-1710378, SNP_A-1650281, SNP_A-1900741, SNP_A-1919267, SNP_A-1818748, SNP_A-1723980, SNP_A-1729420, SNP_A-1655089, SNP_A-1744585, SNP_A-1717291, SNP_A-1757914, SNP_A-1663892, SNP_A-1743278, SNP_A-4253184, SNP_A-1705633, SNP_A-2091688, SNP_A-1857197, SNP_A-2125420, SNP_A-2113848, SNP_A-1720289, SNP_A-4278076, SNP_A-4274337, SNP_A-1755369, SNP_A-1736121, SNP_A-1676898, SNP_A-1685483, SNP_A-1716969, SNP_A-1672383, SNP_A-1728628, SNP_A-4218694, SNP_A-2252945, SNP_A-1957879, SNP_A-4192497, SNP_A-1695616, SNP_A-2279647, SNP_A-1947195, SNP_A-1744170, SNP_A-1753304, SNP_A-2051303, SNP_A-1679739, SNP_A-1873479, SNP_A-4216220, SNP_A-1693314, SNP_A-2051358, SNP_A-4245926, SNP_A-2176097, SNP_A-1923298, SNP_A-4274475, SNP_A-1665881, SNP_A-2022182, SNP_A-1720636, SNP_A-1870592, SNP_A-1882797, SNP_A-1746786, SNP_A-1789642, SNP_A-4218850, SNP_A-1715612, SNP_A-1722705, SNP_A-1696169, SNP_A-1748612, SNP_A-1644799, SNP_A-1714924, SNP_A-1723969, SNP_A-1656702, SNP_A-1663731, SNP_A-1668970, SNP_A-1734910, SNP_A-1700574, SNP_A-1735044, SNP_A-1724210, SNP_A-1753405, SNP_A-1684354, SNP_A-1759009, SNP_A-1681732, SNP_A-1667564, SNP_A-1738246, SNP_A-1644376, SNP_A-1695586, SNP_A-1648109, SNP_A-1709368, SNP_A-1718530,

SNP_A-1654772, SNP_A-1700198, SNP_A-1755701, SNP_A-1648883, SNP_A-1699232, SNP_A-2055890, SNP_A-1958854, SNP_A-1709311, SNP_A-1719165, SNP_A-1665606, SNP_A-1663398, SNP_A-1715627, SNP_A-1677704, SNP_A-1735030, SNP_A-1726756, SNP_A-1747009, SNP_A-1675495, SNP_A-1716019, SNP_A-1666698, SNP_A-1668506, SNP_A-1714234, SNP_A-1645145, SNP_A-1687223, SNP_A-1651168, SNP_A-1669567, SNP_A-1756899, SNP_A-1723219, SNP_A-1726411, SNP_A-1732738, SNP_A-2164335, SNP_A-1655342, SNP_A-1713158, SNP_A-1723052, SNP_A-1649361, SNP_A-1651457, SNP_A-1712429, SNP_A-1708742, SNP_A-1748176, SNP_A-1799383, SNP_A-2303176, SNP_A-1740244, SNP_A-4228188, SNP_A-2103376, SNP_A-1811195, SNP_A-1748792, SNP_A-4249542, SNP_A-1749154, SNP_A-2058373, SNP_A-8528799, SNP_A-8327089, SNP_A-8403074, SNP_A-8583576, SNP_A-2058476, SNP_A-1830271, SNP_A-1931528, SNP_A-2172995, SNP_A-1913320, SNP_A-1929019, SNP_A-1880308, SNP_A-1720952, SNP_A-2033156, SNP_A-2299280, SNP_A-1825682, SNP_A-4292750, SNP_A-1812758, SNP_A-1922806, SNP_A-8639956, SNP_A-8311427, SNP_A-2203072, SNP_A-8447230, SNP_A-8531840, SNP_A-4300883, SNP_A-8553425, SNP_A-8383011, SNP_A-4244370, SNP_A-1890691, SNP_A-1833055, SNP_A-2002713, SNP_A-2224568, SNP_A-8542913, SNP_A-8494245, SNP_A-8435340, SNP_A-8493975, SNP_A-8480101, SNP_A-8444560, SNP_A-2209201, SNP_A-8610215, SNP_A-8373495, SNP_A-8379105, SNP_A-4219179, SNP_A-1852793, SNP_A-8387669, SNP_A-2264550, SNP_A-1910122, SNP_A-8523682, SNP_A-8636712, SNP_A-1938145, SNP_A-2185340, SNP_A-4253870, SNP_A-1794461, SNP_A-2088027, SNP_A-1644939, SNP_A-1869691, SNP_A-4273446, SNP_A-8423426, SNP_A-1688011, SNP_A-2144802, SNP_A-1690200, SNP_A-1883112, SNP_A-8688302, SNP_A-1737712, SNP_A-2237923, SNP_A-1704174, SNP_A-1641934, SNP_A-1645979, SNP_A-1692661, SNP_A-1701510, SNP_A-1686613, SNP_A-2209512, SNP_A-1707671, SNP_A-1666452, SNP_A-1644842, SNP_A-1929899, SNP_A-1722991, SNP_A-1956264, SNP_A-1678996, SNP_A-4276520, SNP_A-1758164, SNP_A-1678637, SNP_A-4268450, SNP_A-2275377, SNP_A-2276161, SNP_A-2153766, SNP_A-1682269, SNP_A-1731083, SNP_A-1680500,

SNP_A-1663289, SNP_A-1785518, SNP_A-8382936, SNP_A-1705615, SNP_A-1735989, SNP_A-8482847, SNP_A-1706178, SNP_A-1758640, SNP_A-2053235, SNP_A-2209186, SNP_A-4285488, SNP_A-8469772, SNP_A-4304028, SNP_A-2286875, SNP_A-2108891, SNP_A-2177109, SNP_A-1810453, SNP_A-1712172, SNP_A-1716020, SNP_A-1721535, SNP_A-1725279, SNP_A-1686056, SNP_A-1657440, SNP_A-1956361, SNP_A-1681972, SNP_A-2242788, SNP_A-1716650, SNP_A-1675187, SNP_A-1666767, SNP_A-1723411, SNP_A-1657234, SNP_A-1721308, SNP_A-1652295, SNP_A-1704636, SNP_A-1713090, SNP_A-8377218, SNP_A-1755257, SNP_A-1646325, SNP_A-1700457, SNP_A-1705738, SNP_A-2261631, SNP_A-1718203, SNP_A-2064206, SNP_A-1724667, SNP_A-1879294, SNP_A-1657934, SNP_A-2051634, SNP_A-1855252, SNP_A-1716342, SNP_A-1745900, SNP_A-4260970, SNP_A-2187058, SNP_A-2064499, SNP_A-4205425, SNP_A-2064554, SNP_A-2064569, SNP_A-2158782, SNP_A-4277892, SNP_A-1881897, SNP_A-1657363, SNP_A-2146122, SNP_A-1736531, SNP_A-1680694, SNP_A-1682070, SNP_A-1706605, SNP_A-4214222, SNP_A-4225095, SNP_A-1827197, SNP_A-8468649, SNP_A-4228922, SNP_A-1688151, SNP_A-1743662, SNP_A-1932801, SNP_A-2303016, SNP_A-2282889, SNP_A-2028443, SNP_A-4303261, SNP_A-1643418, SNP_A-2096495, SNP_A-2058386, SNP_A-1855971, SNP_A-1838243, SNP_A-1649533, SNP_A-1696249, SNP_A-2303174, SNP_A-1746754, SNP_A-1865919, SNP_A-2260554, SNP_A-4195315, SNP_A-1745943, SNP_A-1946711, SNP_A-1911416, SNP_A-1682791, SNP_A-8700577, SNP_A-1646639, SNP_A-1692107, SNP_A-1744500, SNP_A-4243735, SNP_A-1670508, SNP_A-1747048, SNP_A-1673179, SNP_A-1643413, SNP_A-1728022, SNP_A-1684698, SNP_A-1753679, SNP_A-4220148, SNP_A-1721091, SNP_A-4204615, SNP_A-2067245, SNP_A-8404557, SNP_A-1855086, SNP_A-2134095, SNP_A-1854141, SNP_A-1821721, SNP_A-1730171, SNP_A-1666035, SNP_A-1670038, SNP_A-1651737, SNP_A-1663623, SNP_A-1703734, SNP_A-1709132, SNP_A-1713004, SNP_A-1714880, SNP_A-2139201, SNP_A-1708712, SNP_A-1757598, SNP_A-1648487, SNP_A-1683563, SNP_A-1747603, SNP_A-1744430, SNP_A-1879771, SNP_A-1748018, SNP_A-2237285, SNP_A-1734444, SNP_A-1664566, SNP_A-1676654,

SNP_A-1742111, SNP_A-1817350, SNP_A-4222361, SNP_A-2065969, SNP_A-8328479, SNP_A-1677037, SNP_A-1723001, SNP_A-8416415, SNP_A-1727207, SNP_A-1657773, SNP_A-1899377, SNP_A-1800466, SNP_A-4220753, SNP_A-2027610, SNP_A-4276656, SNP_A-1869534, SNP_A-1700926, SNP_A-1704918, SNP_A-8536131, SNP_A-1733439, SNP_A-1663763, SNP_A-1670855, SNP_A-1719940, SNP_A-2047936, SNP_A-1715692, SNP_A-1650063, SNP_A-1695548, SNP_A-1708005, SNP_A-1689798, SNP_A-1650086, SNP_A-1662637, SNP_A-1642071, SNP_A-1714252, SNP_A-2071946, SNP_A-1754375, SNP_A-1647403, SNP_A-2133269, SNP_A-2059557, SNP_A-8563373, SNP_A-2002837, SNP_A-2138549, SNP_A-2289759, SNP_A-2056156, SNP_A-1700670, SNP_A-1666292, SNP_A-2072683, SNP_A-1721832, SNP_A-2238244, SNP_A-2265486, SNP_A-1758814, SNP_A-2072843, SNP_A-1756109, SNP_A-1699684, SNP_A-1744400, SNP_A-4220668, SNP_A-1677925, SNP_A-2069316, SNP_A-2093263, SNP_A-4250829, SNP_A-2308062, SNP_A-2054346, SNP_A-1807632, SNP_A-1756245, SNP_A-1642086, SNP_A-4276496, SNP_A-2259488, SNP_A-1692363, SNP_A-2278963, SNP_A-1681157, SNP_A-1737082, SNP_A-1749230, SNP_A-8446087, SNP_A-2168506, SNP_A-8527113, SNP_A-2178527, SNP_A-1851775, SNP_A-2269762, SNP_A-4201303, SNP_A-1844786, SNP_A-1820079, SNP_A-4229324, SNP_A-4217212, SNP_A-1930797, SNP_A-2065540, SNP_A-1824583, SNP_A-1943873, SNP_A-1650757, SNP_A-1750105, SNP_A-1693186, SNP_A-1728487, SNP_A-1753464, SNP_A-1642650, SNP_A-1718937, SNP_A-1747267, SNP_A-1728781, SNP_A-1753716, SNP_A-1693526, SNP_A-1700433, SNP_A-1684379, SNP_A-1691207, SNP_A-1735383, SNP_A-1687932, SNP_A-4193966, SNP_A-1951730, SNP_A-2150798, SNP_A-1673800, SNP_A-1697933, SNP_A-1688732, SNP_A-1675816, SNP_A-1705603, SNP_A-1672528, SNP_A-1649714, SNP_A-1665233, SNP_A-1748870, SNP_A-1645273, SNP_A-1746061, SNP_A-1743354, SNP_A-1669750, SNP_A-8315382, SNP_A-4231633, SNP_A-2067575, SNP_A-2062855, SNP_A-2021816, SNP_A-1896188, SNP_A-2123338, SNP_A-4286429, SNP_A-1924681, SNP_A-1902189, SNP_A-4304144, SNP_A-1794020, SNP_A-2080577, SNP_A-2059806, SNP_A-2086552, SNP_A-4222246, SNP_A-2086626, SNP_A-1643681,

SNP_A-1687603, SNP_A-1691315, SNP_A-1698266, SNP_A-1743504, SNP_A-1857700, SNP_A-4278367, SNP_A-2152611, SNP_A-2314215, SNP_A-2125459, SNP_A-4222042, SNP_A-4225548, SNP_A-1676277, SNP_A-1668289, SNP_A-1724583, SNP_A-2200603, SNP_A-4254340, SNP_A-2054984, SNP_A-2127056, SNP_A-1755074, SNP_A-1899321, SNP_A-1693315, SNP_A-4222344, SNP_A-4228436, SNP_A-1758559, SNP_A-1647698, SNP_A-1687570, SNP_A-1678450, SNP_A-1727210, SNP_A-1933120, SNP_A-2221317, SNP_A-1704324, SNP_A-4229475, SNP_A-2003001, SNP_A-2067190, SNP_A-2094058, SNP_A-1704762, SNP_A-1754789, SNP_A-1665516, SNP_A-1722642, SNP_A-1698615, SNP_A-1662800, SNP_A-1653034, SNP_A-1642865, SNP_A-1755688, SNP_A-1740669, SNP_A-2208701, SNP_A-1718426, SNP_A-1720022, SNP_A-1730380, SNP_A-1657913, SNP_A-1715602, SNP_A-1648663, SNP_A-2239662, SNP_A-1659035, SNP_A-1685125, SNP_A-4278489, SNP_A-4272432, SNP_A-1675899, SNP_A-1723289, SNP_A-4282689, SNP_A-2308436, SNP_A-1734734, SNP_A-1687810, SNP_A-1711880, SNP_A-1751581, SNP_A-1757669, SNP_A-1751487, SNP_A-4247940, SNP_A-4279990, SNP_A-1646775, SNP_A-2217134, SNP_A-1691334, SNP_A-1895311, SNP_A-1741053, SNP_A-2072257, SNP_A-1713117, SNP_A-1742451, SNP_A-1677150, SNP_A-2210830, SNP_A-1789489, SNP_A-1665690, SNP_A-2107809, SNP_A-1745642, SNP_A-1931591, SNP_A-1712599, SNP_A-1753274, SNP_A-1665210, SNP_A-1733746, SNP_A-1642399, SNP_A-1671719, SNP_A-1680718, SNP_A-1734855, SNP_A-1729112, SNP_A-1655216, SNP_A-1700872, SNP_A-1744198, SNP_A-1673417, SNP_A-1689696, SNP_A-1698602, SNP_A-1700142, SNP_A-1741702, SNP_A-1750594, SNP_A-1682005, SNP_A-2175633, SNP_A-2090955, SNP_A-2136652, SNP_A-1732887, SNP_A-1734655, SNP_A-1734875, SNP_A-1669020, SNP_A-1697138, SNP_A-1662864, SNP_A-1644470, SNP_A-1717867, SNP_A-1880400, SNP_A-2149960, SNP_A-2215394, SNP_A-1792409, SNP_A-4274264, SNP_A-2212402, SNP_A-4246405, SNP_A-2200366, SNP_A-2257453, SNP_A-2052878, SNP_A-4220419, SNP_A-2309607, SNP_A-2277712, SNP_A-2049262, SNP_A-1929900, SNP_A-1868378, SNP_A-8658932, SNP_A-8448762, SNP_A-8531775, SNP_A-2168423, SNP_A-1867229, SNP_A-1793840,

SNP_A-1888303, SNP_A-8652698, SNP_A-2222201, SNP_A-1814651, SNP_A-4296322, SNP_A-2277744, SNP_A-1749584, SNP_A-1698258, SNP_A-1743502, SNP_A-1752644, SNP_A-1646871, SNP_A-1653441, SNP_A-1702744, SNP_A-1711517, SNP_A-1751680, SNP_A-1691327, SNP_A-1703672, SNP_A-1755527, SNP_A-1740936, SNP_A-1744424, SNP_A-1673833, SNP_A-1700246, SNP_A-1707670, SNP_A-8298348, SNP_A-1950323, SNP_A-1802982, SNP_A-8695024, SNP_A-1833083, SNP_A-1644668, SNP_A-8553045, SNP_A-1686026, SNP_A-1664915, SNP_A-1678162, SNP_A-1748582, SNP_A-1757410, SNP_A-1665802, SNP_A-1738548, SNP_A-2102566, SNP_A-8598621, SNP_A-1676396, SNP_A-2103264, SNP_A-1673544, SNP_A-1729803, SNP_A-8476794, SNP_A-2024969, SNP_A-1674352, SNP_A-1717842, SNP_A-1740765, SNP_A-1654370, SNP_A-1712619, SNP_A-1720640, SNP_A-1844384, SNP_A-1754879, SNP_A-4246672, SNP_A-4252317, SNP_A-2243966, SNP_A-1752937, SNP_A-1668134, SNP_A-1673768, SNP_A-1666710, SNP_A-2270461, SNP_A-2106414, SNP_A-1956718, SNP_A-2133938, SNP_A-2114870, SNP_A-2222275, SNP_A-2261166, SNP_A-2111749, SNP_A-2096743, SNP_A-2197959, SNP_A-4240403, SNP_A-4258572, SNP_A-4279255, SNP_A-2123734, SNP_A-2210609, SNP_A-2132771, SNP_A-4249846, SNP_A-1865507, SNP_A-1749830, SNP_A-1755567, SNP_A-4218931, SNP_A-1941792, SNP_A-1736201, SNP_A-2268866, SNP_A-1714691, SNP_A-2292640, SNP_A-8636578, SNP_A-8503000, SNP_A-8453514, SNP_A-8444034, SNP_A-1810225, SNP_A-4293859, SNP_A-1711573, SNP_A-1663499, SNP_A-4231321, SNP_A-4214257, SNP_A-2040890, SNP_A-1655914, SNP_A-1711391, SNP_A-1720720, SNP_A-1757776, SNP_A-1695402, SNP_A-1751700, SNP_A-1647977, SNP_A-1667489, SNP_A-1645871, SNP_A-1692577, SNP_A-1712626, SNP_A-1750218, SNP_A-1644739, SNP_A-2280413, SNP_A-2296371, SNP_A-1872845, SNP_A-2287451, SNP_A-2264077, SNP_A-4239684, SNP_A-1877433, SNP_A-1719247, SNP_A-1727873, SNP_A-1647750, SNP_A-1699305, SNP_A-1646062, SNP_A-1709073, SNP_A-2258004, SNP_A-4204717, SNP_A-1900784, SNP_A-1727984, SNP_A-1660320, SNP_A-1662559, SNP_A-1671003, SNP_A-1725312, SNP_A-1707910, SNP_A-1659805, SNP_A-1706686, SNP_A-1697490, SNP_A-1704616,

SNP_A-1756696, SNP_A-1691169, SNP_A-1666255, SNP_A-1717250, SNP_A-1694009, SNP_A-1724424, SNP_A-1709023, SNP_A-1696810, SNP_A-1667710, SNP_A-1703405, SNP_A-1733174, SNP_A-1729826, SNP_A-1758319, SNP_A-1701816, SNP_A-1716216, SNP_A-1709604, SNP_A-2123048, SNP_A-1872037, SNP_A-1691307, SNP_A-1740474, SNP_A-1683783, SNP_A-1739790, SNP_A-1678055, SNP_A-4282775, SNP_A-1752936, SNP_A-1649701, SNP_A-8460091, SNP_A-8703582, SNP_A-2231686, SNP_A-1951787, SNP_A-1949449, SNP_A-1914522, SNP_A-2282561, SNP_A-2141756, SNP_A-2133279, SNP_A-2227461, SNP_A-1666388, SNP_A-1643453, SNP_A-1673360, SNP_A-1685446, SNP_A-1660597, SNP_A-1663728, SNP_A-1658049, SNP_A-1662113, SNP_A-1668585, SNP_A-1719454, SNP_A-1654082, SNP_A-1708189, SNP_A-2123364, SNP_A-1693913, SNP_A-1817087, SNP_A-1698669, SNP_A-1655573, SNP_A-1860917, SNP_A-1703483, SNP_A-1794300, SNP_A-1650501, SNP_A-1716536, SNP_A-1724185, SNP_A-1666693, SNP_A-1712220, SNP_A-1719500, SNP_A-1701264, SNP_A-8643903, SNP_A-1648720, SNP_A-1645620, SNP_A-1755862, SNP_A-1691136, SNP_A-1646220, SNP_A-1693288, SNP_A-1721311, SNP_A-2249802, SNP_A-4214269, SNP_A-2177532, SNP_A-1884431, SNP_A-1825651, SNP_A-2049328, SNP_A-1683729, SNP_A-2029898, SNP_A-1738321, SNP_A-2116244, SNP_A-1672715, SNP_A-8481458, SNP_A-1662923, SNP_A-1720624, SNP_A-1653305, SNP_A-1665763, SNP_A-1666047, SNP_A-1690478, SNP_A-1743058, SNP_A-1671892, SNP_A-1658818, SNP_A-1929546, SNP_A-1663282, SNP_A-1731987, SNP_A-4225898, SNP_A-1919581, SNP_A-8431116, SNP_A-8314063, SNP_A-1814420, SNP_A-8544705, SNP_A-2103971, SNP_A-8288353, SNP_A-2135654, SNP_A-2118000, SNP_A-1697365, SNP_A-1706550, SNP_A-1749826, SNP_A-1644437, SNP_A-1690222, SNP_A-1749376, SNP_A-1752960, SNP_A-1756608, SNP_A-1684299, SNP_A-1692873, SNP_A-1737052, SNP_A-1745631, SNP_A-1752299, SNP_A-1671656, SNP_A-1732947, SNP_A-1682440, SNP_A-1738621, SNP_A-1742673, SNP_A-1672883, SNP_A-1684848, SNP_A-1743270, SNP_A-1674848, SNP_A-1685303, SNP_A-1732625, SNP_A-1737672, SNP_A-1664927, SNP_A-2133407, SNP_A-1813991, SNP_A-2142761, SNP_A-2142774, SNP_A-2142793,

SNP_A-1822623, SNP_A-1654215, SNP_A-1712669, SNP_A-1678858, SNP_A-1655269, SNP_A-1731271, SNP_A-1696546, SNP_A-1663490, SNP_A-1858606, SNP_A-1861345, SNP_A-4297376, SNP_A-2145034, SNP_A-1679740, SNP_A-1729636, SNP_A-1663640, SNP_A-1710459, SNP_A-1741119, SNP_A-1689791, SNP_A-1698656, SNP_A-1747276, SNP_A-1680067, SNP_A-1683909, SNP_A-1739530, SNP_A-1749910, SNP_A-1675999, SNP_A-2146528, SNP_A-1686819, SNP_A-4194014, SNP_A-1879100, SNP_A-1678478, SNP_A-1749121, SNP_A-1684654, SNP_A-1684076, SNP_A-1743767, SNP_A-1655479, SNP_A-1745258, SNP_A-1753473, SNP_A-1694653, SNP_A-1711198, SNP_A-1683728, SNP_A-1723200, SNP_A-1661504, SNP_A-1642031, SNP_A-4301065, SNP_A-1782807, SNP_A-2125645, SNP_A-4286013, SNP_A-1848629, SNP_A-4277636, SNP_A-1899184, SNP_A-1922576, SNP_A-4227748, SNP_A-2199672, SNP_A-2154718, SNP_A-1877117, SNP_A-2155093, SNP_A-2186444, SNP_A-4200678, SNP_A-8561158, SNP_A-2156862, SNP_A-1785571, SNP_A-1814688, SNP_A-2277766, SNP_A-2060031, SNP_A-2159886, SNP_A-2305592, SNP_A-2271229, SNP_A-4200517, SNP_A-2133597, SNP_A-2271251, SNP_A-8583284, SNP_A-8352819, SNP_A-8365944, SNP_A-8447667, SNP_A-8640927, SNP_A-1734615, SNP_A-1744974, SNP_A-1677995, SNP_A-1737781, SNP_A-1673637, SNP_A-1755978, SNP_A-1755136, SNP_A-1738851, SNP_A-1709643, SNP_A-1743791, SNP_A-1656019, SNP_A-1713226, SNP_A-1654844, SNP_A-1743672, SNP_A-1737993, SNP_A-1732223, SNP_A-1669338, SNP_A-1739533, SNP_A-1742375, SNP_A-1748005, SNP_A-4261038, SNP_A-2250549, SNP_A-1656187, SNP_A-4201055, SNP_A-1657827, SNP_A-1704922, SNP_A-1755677, SNP_A-1688221, SNP_A-1693293, SNP_A-2166374, SNP_A-2093405, SNP_A-1699382, SNP_A-1747644, SNP_A-4232260, SNP_A-2081415, SNP_A-2239206, SNP_A-1688089, SNP_A-1747002, SNP_A-1680143, SNP_A-1685391, SNP_A-1869474, SNP_A-1739590, SNP_A-1672595, SNP_A-1733917, SNP_A-4218464, SNP_A-2117759, SNP_A-8644091, SNP_A-2071870, SNP_A-8583792, SNP_A-8413830, SNP_A-2230210, SNP_A-1948765, SNP_A-4258389, SNP_A-8660562, SNP_A-1901877, SNP_A-2172711, SNP_A-1848570, SNP_A-2161986, SNP_A-8580110, SNP_A-8501318, SNP_A-8655843,

SNP_A-1646998, SNP_A-1890703, SNP_A-1670824, SNP_A-4205596, SNP_A-1688202, SNP_A-1710167, SNP_A-8699449, SNP_A-1670686, SNP_A-1707934, SNP_A-8439322, SNP_A-8655204, SNP_A-4200560, SNP_A-8585544, SNP_A-1887302, SNP_A-2064152, SNP_A-1672867, SNP_A-1742274, SNP_A-1731854, SNP_A-4202625, SNP_A-1699934, SNP_A-4253913, SNP_A-1838533, SNP_A-4304126, SNP_A-2066550, SNP_A-2296578, SNP_A-1656996, SNP_A-1837485, SNP_A-1837153, SNP_A-1665795, SNP_A-1860514, SNP_A-1707861, SNP_A-1711509, SNP_A-2003506, SNP_A-2069495, SNP_A-1746095, SNP_A-1738594, SNP_A-2125469, SNP_A-1663581, SNP_A-1723705, SNP_A-1652691, SNP_A-1950693, SNP_A-1818904, SNP_A-2177630, SNP_A-2258862, SNP_A-1790759, SNP_A-2269520, SNP_A-1883647, SNP_A-4303964, SNP_A-2003519, SNP_A-2243115, SNP_A-2189920, SNP_A-2179099, SNP_A-1693099, SNP_A-1696641, SNP_A-1743612, SNP_A-2179977, SNP_A-4230045, SNP_A-1735085, SNP_A-4227272, SNP_A-2180929, SNP_A-1938804, SNP_A-1868499, SNP_A-1939793, SNP_A-2220405, SNP_A-8463965, SNP_A-4192750, SNP_A-1693413, SNP_A-1653382, SNP_A-1697881, SNP_A-2071197, SNP_A-1830980, SNP_A-2066021, SNP_A-1799280, SNP_A-1718662, SNP_A-1658772, SNP_A-1680252, SNP_A-1649686, SNP_A-1662320, SNP_A-1671524, SNP_A-1664646, SNP_A-1679711, SNP_A-1690406, SNP_A-1733799, SNP_A-1682711, SNP_A-1669728, SNP_A-1731136, SNP_A-1733229, SNP_A-1717864, SNP_A-1659653, SNP_A-1705116, SNP_A-1711833, SNP_A-2168822, SNP_A-2298447, SNP_A-1736253, SNP_A-1693235, SNP_A-1711691, SNP_A-1715644, SNP_A-1671510, SNP_A-1758595, SNP_A-1786967, SNP_A-2003598, SNP_A-1798391, SNP_A-4293082, SNP_A-1677437, SNP_A-1934822, SNP_A-8681445, SNP_A-1716851, SNP_A-2253413, SNP_A-8587371, SNP_A-1782466, SNP_A-1745948, SNP_A-8699244, SNP_A-1837486, SNP_A-2147430, SNP_A-1744958, SNP_A-1859045, SNP_A-1677577, SNP_A-2275327, SNP_A-1728271, SNP_A-4299851, SNP_A-2191167, SNP_A-1693300, SNP_A-1731254, SNP_A-8554981, SNP_A-8599359, SNP_A-1812098, SNP_A-2101351, SNP_A-4275742, SNP_A-2118632, SNP_A-2107366, SNP_A-4247379, SNP_A-2003613, SNP_A-1781421, SNP_A-2003617, SNP_A-2266542, SNP_A-2061490,

SNP_A-4235803, SNP_A-1831970, SNP_A-2021632, SNP_A-2106011, SNP_A-8639879, SNP_A-2036194, SNP_A-1752014, SNP_A-1677461, SNP_A-1684549, SNP_A-1709504, SNP_A-1651111, SNP_A-1694174, SNP_A-1708732, SNP_A-2202511, SNP_A-2178665, SNP_A-4239881, SNP_A-2049273, SNP_A-4268590, SNP_A-1789577, SNP_A-1679548, SNP_A-1748559, SNP_A-1698045, SNP_A-1731905, SNP_A-1755194, SNP_A-1756651, SNP_A-1660643, SNP_A-1808242, SNP_A-1745457, SNP_A-1649389, SNP_A-1657859, SNP_A-8588209, SNP_A-2284743, SNP_A-1884388, SNP_A-2259059, SNP_A-2205225, SNP_A-8593837, SNP_A-1949885, SNP_A-8290190, SNP_A-4290519, SNP_A-8649369, SNP_A-8382811, SNP_A-8326514, SNP_A-4299248, SNP_A-1835770, SNP_A-1872014, SNP_A-4222292, SNP_A-2112599, SNP_A-4207055, SNP_A-2033005, SNP_A-4298226, SNP_A-1915528, SNP_A-4238139, SNP_A-2208574, SNP_A-4255024, SNP_A-1706784, SNP_A-1710318, SNP_A-1757468, SNP_A-1648723, SNP_A-1641976, SNP_A-1663411, SNP_A-2054734, SNP_A-1710571, SNP_A-1961421, SNP_A-2210998, SNP_A-2172877, SNP_A-2003697, SNP_A-4232612, SNP_A-1653180, SNP_A-1648754, SNP_A-1750655, SNP_A-1708602, SNP_A-1716213, SNP_A-2210648, SNP_A-1701975, SNP_A-4202324, SNP_A-2118782, SNP_A-2210687, SNP_A-1682195, SNP_A-1687569, SNP_A-1738458, SNP_A-1670951, SNP_A-1672825, SNP_A-1697958, SNP_A-1642566, SNP_A-1803211, SNP_A-1696991, SNP_A-4232740, SNP_A-2296692, SNP_A-1820141, SNP_A-1852093, SNP_A-2230667, SNP_A-2170871, SNP_A-1959942, SNP_A-2248729, SNP_A-2211481, SNP_A-4293520, SNP_A-2206666, SNP_A-1873653, SNP_A-1751184, SNP_A-1686163, SNP_A-1665931, SNP_A-2212184, SNP_A-1896784, SNP_A-1902857, SNP_A-4244926, SNP_A-2212289, SNP_A-4300194, SNP_A-1759043, SNP_A-1709961, SNP_A-1688594, SNP_A-1752171, SNP_A-1645382, SNP_A-4238055, SNP_A-2073539, SNP_A-1913602, SNP_A-2213267, SNP_A-1663303, SNP_A-1719146, SNP_A-1673600, SNP_A-1666075, SNP_A-1711467, SNP_A-1646423, SNP_A-1717771, SNP_A-1675912, SNP_A-1737573, SNP_A-1933466, SNP_A-4273690, SNP_A-4294257, SNP_A-4278854, SNP_A-1924125, SNP_A-1862887, SNP_A-2003735, SNP_A-2193251, SNP_A-1874956, SNP_A-4292476, SNP_A-2227358,

SNP_A-1679943, SNP_A-2142603, SNP_A-1683757, SNP_A-4233138, SNP_A-4231579, SNP_A-2261118, SNP_A-2242119, SNP_A-1657220, SNP_A-4233154, SNP_A-1705736, SNP_A-2003742, SNP_A-2310220, SNP_A-1890553, SNP_A-4244125, SNP_A-8442424, SNP_A-1710005, SNP_A-2060267, SNP_A-1701197, SNP_A-4249185, SNP_A-2289845, SNP_A-1714943, SNP_A-1684876, SNP_A-1751061, SNP_A-4293583, SNP_A-1781627, SNP_A-2308493, SNP_A-1796171, SNP_A-1954329, SNP_A-4192911, SNP_A-1793761, SNP_A-4230460, SNP_A-1668363, SNP_A-1721559, SNP_A-1652079, SNP_A-1680599, SNP_A-1739936, SNP_A-1661054, SNP_A-1886539, SNP_A-1860562, SNP_A-2164183, SNP_A-2087940, SNP_A-2077729, SNP_A-2294300, SNP_A-2023627, SNP_A-8638025, SNP_A-2250360, SNP_A-2223910, SNP_A-8321954, SNP_A-1758000, SNP_A-1736949, SNP_A-1741423, SNP_A-1731265, SNP_A-1644814, SNP_A-2182939, SNP_A-1698261, SNP_A-2168236, SNP_A-1914795, SNP_A-4206217, SNP_A-1900050, SNP_A-1687273, SNP_A-4243946, SNP_A-1733165, SNP_A-1736654, SNP_A-1676453, SNP_A-1725463, SNP_A-1732180, SNP_A-8713428, SNP_A-2003794, SNP_A-1830559, SNP_A-4293919, SNP_A-1669217, SNP_A-1708703, SNP_A-1745336, SNP_A-1723372, SNP_A-1754866, SNP_A-1656955, SNP_A-1746799, SNP_A-1712517, SNP_A-4207552, SNP_A-4223907, SNP_A-2117672, SNP_A-2247459, SNP_A-2107071, SNP_A-2072564, SNP_A-1863335, SNP_A-1904923, SNP_A-1864727, SNP_A-2118670, SNP_A-4222630, SNP_A-2161711, SNP_A-2258493, SNP_A-4234294, SNP_A-4225163, SNP_A-2243212, SNP_A-4197584, SNP_A-2228714, SNP_A-1907307, SNP_A-4282618, SNP_A-2246845, SNP_A-1821032, SNP_A-2160954, SNP_A-2259085, SNP_A-2235593, SNP_A-2151569, SNP_A-4295259, SNP_A-2228280, SNP_A-1786048, SNP_A-8500688, SNP_A-2172524, SNP_A-1905727, SNP_A-2042348, SNP_A-8370036, SNP_A-2243076, SNP_A-8291047, SNP_A-1836488, SNP_A-1852644, SNP_A-2241728, SNP_A-1842531, SNP_A-1819968, SNP_A-1784946, SNP_A-2194481, SNP_A-4231390, SNP_A-2296032, SNP_A-1829562, SNP_A-8654519, SNP_A-1683501, SNP_A-1692483, SNP_A-1741162, SNP_A-2235022, SNP_A-1670487, SNP_A-1673951, SNP_A-1736918, SNP_A-1671255, SNP_A-1706776, SNP_A-2027685, SNP_A-1861826,

SNP_A-2082609, SNP_A-1862397, SNP_A-2077209, SNP_A-4235027, SNP_A-2310086, SNP_A-4235096, SNP_A-8608885, SNP_A-8328631, SNP_A-8635738, SNP_A-2003892, SNP_A-8649337, SNP_A-1677356, SNP_A-1752569, SNP_A-1757021, SNP_A-1646552, SNP_A-1746488, SNP_A-1749791, SNP_A-1713859, SNP_A-1643056, SNP_A-1653559, SNP_A-1643772, SNP_A-1756812, SNP_A-1691835, SNP_A-1730449, SNP_A-1693036, SNP_A-1643250, SNP_A-1751190, SNP_A-1685949, SNP_A-1696377, SNP_A-1740022, SNP_A-1743242, SNP_A-1752348, SNP_A-1731148, SNP_A-1713442, SNP_A-1659080, SNP_A-1685100, SNP_A-1729450, SNP_A-1693805, SNP_A-1731044, SNP_A-1661673, SNP_A-1668956, SNP_A-1645077, SNP_A-1692039, SNP_A-1701132, SNP_A-1740667, SNP_A-1751751, SNP_A-1649082, SNP_A-1689274, SNP_A-1645964, SNP_A-1699001, SNP_A-1662182, SNP_A-1642985, SNP_A-1663924, SNP_A-1934157, SNP_A-1958998, SNP_A-1786279, SNP_A-1911914, SNP_A-2119013, SNP_A-1645868, SNP_A-1674591, SNP_A-1683482, SNP_A-1674219, SNP_A-1651192, SNP_A-1750381, SNP_A-1749795, SNP_A-1646680, SNP_A-1695189, SNP_A-1732532, SNP_A-1746639, SNP_A-1672070, SNP_A-2245572, SNP_A-4203764, SNP_A-1907424, SNP_A-2120298, SNP_A-4226532, SNP_A-2270743, SNP_A-1803452, SNP_A-1665471, SNP_A-1705858, SNP_A-1707919, SNP_A-1659637, SNP_A-2158819, SNP_A-1808416, SNP_A-1880587, SNP_A-2256059, SNP_A-1920515, SNP_A-4240242, SNP_A-4233609, SNP_A-2222896, SNP_A-1737977, SNP_A-1741132, SNP_A-1675965, SNP_A-1801983, SNP_A-1725887, SNP_A-1755347, SNP_A-1644903, SNP_A-1695278, SNP_A-1700385, SNP_A-2111346, SNP_A-2255765, SNP_A-4285448, SNP_A-1692721, SNP_A-2223927, SNP_A-1894977, SNP_A-1715763, SNP_A-2175419, SNP_A-1695325, SNP_A-1711749, SNP_A-1753270, SNP_A-2051090, SNP_A-1672332, SNP_A-1672758, SNP_A-1716521, SNP_A-1682624, SNP_A-1732522, SNP_A-1744053, SNP_A-1697773, SNP_A-1679742, SNP_A-1652345, SNP_A-4244846, SNP_A-1651770, SNP_A-2214465, SNP_A-2129687, SNP_A-1814529, SNP_A-1680594, SNP_A-1757048, SNP_A-1645252, SNP_A-1743782, SNP_A-1756366, SNP_A-1685419, SNP_A-2301423, SNP_A-2052933, SNP_A-1705772, SNP_A-2199851, SNP_A-1884987, SNP_A-1756287,

SNP_A-2251584, SNP_A-1654316, SNP_A-4236114, SNP_A-2251623, SNP_A-2154649, SNP_A-1874919, SNP_A-4272534, SNP_A-4274049, SNP_A-1735031, SNP_A-1808988, SNP_A-1681437, SNP_A-1706278, SNP_A-2189384, SNP_A-1756688, SNP_A-2211185, SNP_A-1691643, SNP_A-4192836, SNP_A-2131743, SNP_A-4236185, SNP_A-2153359, SNP_A-2190012, SNP_A-4236218, SNP_A-2029506, SNP_A-1654451, SNP_A-1699767, SNP_A-1731697, SNP_A-1659989, SNP_A-1718151, SNP_A-1801859, SNP_A-2070089, SNP_A-4291564, SNP_A-8360959, SNP_A-8582191, SNP_A-1902122, SNP_A-8677900, SNP_A-1649941, SNP_A-4268635, SNP_A-2184071, SNP_A-1712890, SNP_A-8485793, SNP_A-1734911, SNP_A-1655892, SNP_A-1658019, SNP_A-1738294, SNP_A-8329047, SNP_A-1677364, SNP_A-1755850, SNP_A-1674177, SNP_A-1861061, SNP_A-1940180, SNP_A-4193810, SNP_A-4233864, SNP_A-2053310, SNP_A-1870603, SNP_A-1864783, SNP_A-4221522, SNP_A-4207524, SNP_A-1659209, SNP_A-1730777, SNP_A-1694223, SNP_A-1656946, SNP_A-1701913, SNP_A-1893368, SNP_A-1708467, SNP_A-4244365, SNP_A-1646607, SNP_A-4241630, SNP_A-2296084, SNP_A-2219629, SNP_A-2255702, SNP_A-1909104, SNP_A-4298404, SNP_A-4290507, SNP_A-1860023, SNP_A-1909412, SNP_A-4227184, SNP_A-1869059, SNP_A-1930159, SNP_A-2228752, SNP_A-1695161, SNP_A-2258761, SNP_A-1687995, SNP_A-1713834, SNP_A-2215350, SNP_A-1887529, SNP_A-4236863, SNP_A-1669336, SNP_A-1671133, SNP_A-1674900, SNP_A-1659962, SNP_A-4272254, SNP_A-2254867, SNP_A-2074644, SNP_A-4253593, SNP_A-2067183, SNP_A-2090337, SNP_A-2158790, SNP_A-4206179, SNP_A-1940442, SNP_A-4199000, SNP_A-2261480, SNP_A-2089036, SNP_A-2080959, SNP_A-1896155, SNP_A-2004029, SNP_A-2143687, SNP_A-1929689, SNP_A-2071063, SNP_A-2088596, SNP_A-1922387, SNP_A-2197976, SNP_A-1753381, SNP_A-1646672, SNP_A-1652025, SNP_A-1657172, SNP_A-1708745, SNP_A-1753891, SNP_A-1806549, SNP_A-1955093, SNP_A-1643945, SNP_A-1649935, SNP_A-4196271, SNP_A-1957719, SNP_A-1705542, SNP_A-1906765, SNP_A-1752570, SNP_A-2186013, SNP_A-4216646, SNP_A-2277202, SNP_A-2263094, SNP_A-1713265, SNP_A-1653624, SNP_A-1717591, SNP_A-1758538, SNP_A-8396010, SNP_A-8408599,

SNP_A-1875326, SNP_A-2062230, SNP_A-1877168, SNP_A-8494101, SNP_A-8701222, SNP_A-4272723, SNP_A-8695583, SNP_A-8304218, SNP_A-8494972, SNP_A-1901797, SNP_A-2295533, SNP_A-2211184, SNP_A-1841234, SNP_A-4228760, SNP_A-1792086, SNP_A-4297021, SNP_A-4280128, SNP_A-2252258, SNP_A-8313205, SNP_A-8651681, SNP_A-4199994, SNP_A-2221244, SNP_A-4203488, SNP_A-8688717, SNP_A-2247657, SNP_A-1818439, SNP_A-1717180, SNP_A-1722903, SNP_A-1746928, SNP_A-1856057, SNP_A-1685489, SNP_A-1796403, SNP_A-1799898, SNP_A-1734427, SNP_A-1685229, SNP_A-1730842, SNP_A-1670164, SNP_A-1794862, SNP_A-1842875, SNP_A-1738658, SNP_A-1668659, SNP_A-4198733, SNP_A-1755463, SNP_A-1755948, SNP_A-1676895, SNP_A-1714725, SNP_A-1725607, SNP_A-1884573, SNP_A-1644486, SNP_A-1666706, SNP_A-1668370, SNP_A-1700649, SNP_A-1699304, SNP_A-1662193, SNP_A-1718124, SNP_A-1722207, SNP_A-1654900, SNP_A-1743477, SNP_A-1739613, SNP_A-1729668, SNP_A-1735763, SNP_A-1665990, SNP_A-1642135, SNP_A-1691582, SNP_A-1661420, SNP_A-1716729, SNP_A-1747423, SNP_A-1646010, SNP_A-1729972, SNP_A-2152829, SNP_A-2270956, SNP_A-1688864, SNP_A-1659726, SNP_A-1740931, SNP_A-1702269, SNP_A-1725130, SNP_A-1714016, SNP_A-1734540, SNP_A-2227198, SNP_A-1957993, SNP_A-1724274, SNP_A-1747021, SNP_A-1664754, SNP_A-1755504, SNP_A-1694179, SNP_A-1755682, SNP_A-1749501, SNP_A-1734656, SNP_A-1679512, SNP_A-1749267, SNP_A-1752695, SNP_A-1648552, SNP_A-1753128, SNP_A-1644545, SNP_A-1798645, SNP_A-1698738, SNP_A-1703844, SNP_A-1677793, SNP_A-1684741, SNP_A-1741956, SNP_A-1682015, SNP_A-8599836, SNP_A-8585244, SNP_A-4274863, SNP_A-2271650, SNP_A-1927308, SNP_A-2053947, SNP_A-4279608, SNP_A-2050239, SNP_A-1910129, SNP_A-1837942, SNP_A-8452349, SNP_A-8659837, SNP_A-8655394, SNP_A-2107404, SNP_A-1803678, SNP_A-2241497, SNP_A-2260934, SNP_A-2107138, SNP_A-4220913, SNP_A-4192611, SNP_A-1943511, SNP_A-2271541, SNP_A-2302007, SNP_A-1895409, SNP_A-2276141, SNP_A-4205575, SNP_A-1724085, SNP_A-2249771, SNP_A-1663369, SNP_A-1644867, SNP_A-1660834, SNP_A-1757056, SNP_A-1653475, SNP_A-1692797, SNP_A-1949916,

SNP_A-2303893, SNP_A-1646462, SNP_A-1642793, SNP_A-1665082, SNP_A-1680440, SNP_A-1707855, SNP_A-2278861, SNP_A-2278928, SNP_A-1694328, SNP_A-2279022, SNP_A-2145386, SNP_A-2197294, SNP_A-1684949, SNP_A-1690588, SNP_A-1731530, SNP_A-1739962, SNP_A-1669236, SNP_A-2161033, SNP_A-2004150, SNP_A-1924334, SNP_A-4238431, SNP_A-2188681, SNP_A-1823808, SNP_A-1805160, SNP_A-2137077, SNP_A-4249012, SNP_A-2139148, SNP_A-2280926, SNP_A-1792502, SNP_A-2217721, SNP_A-4197583, SNP_A-4193113, SNP_A-1900621, SNP_A-2282501, SNP_A-1742265, SNP_A-1656419, SNP_A-1690315, SNP_A-1698887, SNP_A-1642995, SNP_A-1705205, SNP_A-4227599, SNP_A-1723691, SNP_A-1654596, SNP_A-8379472, SNP_A-1704814, SNP_A-8629588, SNP_A-1646427, SNP_A-1653839, SNP_A-1751000, SNP_A-1645599, SNP_A-1697610, SNP_A-1685697, SNP_A-1691275, SNP_A-2134684, SNP_A-1709254, SNP_A-1716400, SNP_A-1721873, SNP_A-1649325, SNP_A-2145245, SNP_A-1796785, SNP_A-1650083, SNP_A-1704048, SNP_A-1694734, SNP_A-1739994, SNP_A-4219143, SNP_A-1642035, SNP_A-1698957, SNP_A-1675969, SNP_A-1720831, SNP_A-1733469, SNP_A-1755689, SNP_A-1690290, SNP_A-1828036, SNP_A-8353363, SNP_A-1780318, SNP_A-1719705, SNP_A-1830167, SNP_A-1699419, SNP_A-1721361, SNP_A-1749329, SNP_A-1740187, SNP_A-1753505, SNP_A-1658686, SNP_A-1724894, SNP_A-1644490, SNP_A-1686476, SNP_A-2143175, SNP_A-1809314, SNP_A-1671256, SNP_A-1711480, SNP_A-1736597, SNP_A-1685028, SNP_A-4194050, SNP_A-1680742, SNP_A-1705627, SNP_A-1733894, SNP_A-8589108, SNP_A-2161867, SNP_A-8646076, SNP_A-8546462, SNP_A-2204354, SNP_A-8611779, SNP_A-2044541, SNP_A-2068993, SNP_A-2230075, SNP_A-1807305, SNP_A-1907177, SNP_A-8705851, SNP_A-2088324, SNP_A-8549755, SNP_A-8404193, SNP_A-2268652, SNP_A-2292795, SNP_A-1853662, SNP_A-2113545, SNP_A-1694850, SNP_A-1738686, SNP_A-2297978, SNP_A-2103808, SNP_A-1681559, SNP_A-1727680, SNP_A-1653415, SNP_A-1681724, SNP_A-1695779, SNP_A-1668490, SNP_A-1689604, SNP_A-1755010, SNP_A-1645064, SNP_A-2294589, SNP_A-2098040, SNP_A-2294613, SNP_A-4220830, SNP_A-1647503, SNP_A-1675727, SNP_A-2295375, SNP_A-1681123,

SNP_A-1689844, SNP_A-2138126, SNP_A-1669810, SNP_A-1675398, SNP_A-1731946, SNP_A-1715458, SNP_A-1719456, SNP_A-1653389, SNP_A-2080116, SNP_A-1665949, SNP_A-1642378, SNP_A-1678007, SNP_A-8603610, SNP_A-4294246, SNP_A-2247324, SNP_A-1705556, SNP_A-8678524, SNP_A-2297195, SNP_A-2119713, SNP_A-1875176, SNP_A-4291364, SNP_A-2274166, SNP_A-4303571, SNP_A-4239917, SNP_A-2229983, SNP_A-1881293, SNP_A-1754054, SNP_A-1658517, SNP_A-1649085, SNP_A-1704862, SNP_A-1746742, SNP_A-2115973, SNP_A-1738834, SNP_A-1750860, SNP_A-1693490, SNP_A-1739344, SNP_A-1683879, SNP_A-1664421, SNP_A-2300038, SNP_A-1749864, SNP_A-2150130, SNP_A-1835534, SNP_A-1684683, SNP_A-1670348, SNP_A-1716918, SNP_A-1661743, SNP_A-2237814, SNP_A-2300545, SNP_A-2191074, SNP_A-2127030, SNP_A-4218584, SNP_A-2036576, SNP_A-1674852, SNP_A-1727752, SNP_A-1668728, SNP_A-2022716, SNP_A-2098932, SNP_A-1649641, SNP_A-1652997, SNP_A-1665309, SNP_A-1703626, SNP_A-1656118, SNP_A-1646285, SNP_A-1670961, SNP_A-1661849, SNP_A-1716002, SNP_A-1721338, SNP_A-1649487, SNP_A-1645031, SNP_A-1650297, SNP_A-4290485, SNP_A-1724236, SNP_A-1661986, SNP_A-1757899, SNP_A-1719651, SNP_A-1666906, SNP_A-1647914, SNP_A-1757957, SNP_A-1693184, SNP_A-1646106, SNP_A-1803051, SNP_A-2004353, SNP_A-2167560, SNP_A-2096906, SNP_A-2310697, SNP_A-1882336, SNP_A-2286219, SNP_A-1870902, SNP_A-1911984, SNP_A-1864187, SNP_A-8536662, SNP_A-1749234, SNP_A-1737917, SNP_A-1752072, SNP_A-1737514, SNP_A-1734345, SNP_A-1702368, SNP_A-1749602, SNP_A-1717497, SNP_A-1704361, SNP_A-2092059, SNP_A-1653602, SNP_A-1661852, SNP_A-1684610, SNP_A-1676790, SNP_A-1650612, SNP_A-1669889, SNP_A-1740827, SNP_A-2306335, SNP_A-4240608, SNP_A-1740512, SNP_A-1648890, SNP_A-1688450, SNP_A-1734659, SNP_A-1667369, SNP_A-1676193, SNP_A-1728916, SNP_A-1666789, SNP_A-1708624, SNP_A-1719616, SNP_A-1715811, SNP_A-1725626, SNP_A-1723056, SNP_A-1750281, SNP_A-1697757, SNP_A-1721217, SNP_A-1712817, SNP_A-1715532, SNP_A-1743443, SNP_A-1665637, SNP_A-1720368, SNP_A-1645695, SNP_A-1709175, SNP_A-1685262, SNP_A-1732003, SNP_A-1696222,

SNP_A-1755032, SNP_A-1656282, SNP_A-1697161, SNP_A-1705968, SNP_A-1642452, SNP_A-1687897, SNP_A-1738378, SNP_A-1716874, SNP_A-2004422, SNP_A-2004424, SNP_A-4200916, SNP_A-1704952, SNP_A-1750396, SNP_A-1645381, SNP_A-1660996, SNP_A-1720786, SNP_A-1714772, SNP_A-1696101, SNP_A-1755345, SNP_A-1686439, SNP_A-1665450, SNP_A-1678647, SNP_A-1691964, SNP_A-1642687, SNP_A-1746734, SNP_A-1662790, SNP_A-4214392, SNP_A-1700643, SNP_A-2234859, SNP_A-2311259, SNP_A-1831243, SNP_A-1838272, SNP_A-2082512, SNP_A-1888934, SNP_A-1647533, SNP_A-1807459, SNP_A-1865048, SNP_A-2085566, SNP_A-1699137, SNP_A-2078251, SNP_A-2160811, SNP_A-1863339, SNP_A-2124970, SNP_A-1670051, SNP_A-1675615, SNP_A-1642177, SNP_A-1707139, SNP_A-2048656, SNP_A-2107791, SNP_A-8712170, SNP_A-1676421, SNP_A-1706415, SNP_A-4228536, SNP_A-1714070, SNP_A-1659615, SNP_A-8512887, SNP_A-8659089, SNP_A-8648051, SNP_A-4279942, SNP_A-1702141, SNP_A-1732380, SNP_A-1938127, SNP_A-1666748, SNP_A-2072540, SNP_A-4291807, SNP_A-2070028, SNP_A-2298910, SNP_A-2280154, SNP_A-2040259, SNP_A-4251244, SNP_A-4289342, SNP_A-4304829, SNP_A-2004494, SNP_A-2245094, SNP_A-2186761, SNP_A-4247524, SNP_A-1878820, SNP_A-1811406, SNP_A-2275258, SNP_A-4196139, SNP_A-4236673, SNP_A-1695832, SNP_A-1750040, SNP_A-2200656, SNP_A-1664031, SNP_A-2275408, SNP_A-1671189, SNP_A-1663327, SNP_A-1687538, SNP_A-2162733, SNP_A-1680862, SNP_A-2046382, SNP_A-1698513, SNP_A-1702468, SNP_A-1714856, SNP_A-2111539, SNP_A-1718057, SNP_A-1676032, SNP_A-2123184, SNP_A-1752479, SNP_A-1758604, SNP_A-1674347, SNP_A-1644276, SNP_A-1684064, SNP_A-1785048, SNP_A-4235389, SNP_A-2238097, SNP_A-2080102, SNP_A-4229316, SNP_A-1904684, SNP_A-1898748, SNP_A-2174427, SNP_A-4250639, SNP_A-2070584, SNP_A-1752371, SNP_A-4296938, SNP_A-1665490, SNP_A-1649502, SNP_A-1654973, SNP_A-1651174, SNP_A-1741571, SNP_A-1717233, SNP_A-1739135, SNP_A-1757009, SNP_A-1719857, SNP_A-1645612, SNP_A-1692088, SNP_A-4285269, SNP_A-4233131, SNP_A-4193033, SNP_A-1787889, SNP_A-4193040, SNP_A-4271730, SNP_A-8587466, SNP_A-4203480, SNP_A-2298229,

SNP_A-8581513, SNP_A-4234885, SNP_A-1726446, SNP_A-1728389, SNP_A-1659548, SNP_A-1672482, SNP_A-1749371, SNP_A-8437621, SNP_A-1698233, SNP_A-8380303, SNP_A-1660633, SNP_A-2094138, SNP_A-1876725, SNP_A-1794747, SNP_A-1835529, SNP_A-1683412, SNP_A-1704717, SNP_A-1644398, SNP_A-1736151, SNP_A-1743093, SNP_A-1693142, SNP_A-1681628, SNP_A-1719043, SNP_A-1739593, SNP_A-1715241, SNP_A-1667484, SNP_A-2252831, SNP_A-8613256, SNP_A-8583563, SNP_A-8429138, SNP_A-1672185, SNP_A-1725059, SNP_A-1730011, SNP_A-1718512, SNP_A-1727642, SNP_A-1668912, SNP_A-1712262, SNP_A-1721228, SNP_A-2027999, SNP_A-2112310, SNP_A-2169720, SNP_A-1900528, SNP_A-1667087, SNP_A-1647399, SNP_A-1700984, SNP_A-1710346, SNP_A-4194060, SNP_A-1792477, SNP_A-2235527, SNP_A-1883740, SNP_A-2109317, SNP_A-2123200, SNP_A-1650177, SNP_A-1664327, SNP_A-2286920, SNP_A-1800720, SNP_A-1825022, SNP_A-2042064, SNP_A-2071600, SNP_A-2222978, SNP_A-1814643, SNP_A-1794701, SNP_A-1740509, SNP_A-1756157, SNP_A-1643705, SNP_A-1751811, SNP_A-1818620, SNP_A-1645445, SNP_A-1682563, SNP_A-1666689, SNP_A-1653480, SNP_A-1725342, SNP_A-1855208, SNP_A-1673711, SNP_A-8401370, SNP_A-8403439, SNP_A-1705117, SNP_A-1850293, SNP_A-2265529, SNP_A-2139570, SNP_A-1660306, SNP_A-2268601, SNP_A-1697998, SNP_A-4214404, SNP_A-1805615, SNP_A-2306691, SNP_A-2004671, SNP_A-2035527, SNP_A-4232858, SNP_A-8350504, SNP_A-4205291, SNP_A-8504692, SNP_A-2127774, SNP_A-8331141, SNP_A-2046913, SNP_A-1745037, SNP_A-2052380, SNP_A-1734013, SNP_A-2076856, SNP_A-1663401, SNP_A-1670066, SNP_A-1743163, SNP_A-1715788, SNP_A-1728975, SNP_A-1679126, SNP_A-1658999, SNP_A-1655423, SNP_A-1797989, SNP_A-1664115, SNP_A-2049198, SNP_A-1795050, SNP_A-2141059, SNP_A-1713377, SNP_A-2034271, SNP_A-1647141, SNP_A-1702718, SNP_A-1731160, SNP_A-1663841, SNP_A-1672275, SNP_A-2084132, SNP_A-1841044, SNP_A-1837574, SNP_A-2208962, SNP_A-4193877, SNP_A-2072879, SNP_A-1808387, SNP_A-1929272, SNP_A-1951796, SNP_A-1799671, SNP_A-4222333, SNP_A-4192781, SNP_A-2157973, SNP_A-2292926, SNP_A-2279648, SNP_A-1921677, SNP_A-2096370,

SNP_A-1960242, SNP_A-1747520, SNP_A-1742846, SNP_A-2267922, SNP_A-1682917, SNP_A-1725479, SNP_A-1733827, SNP_A-8529117, SNP_A-4233297, SNP_A-1921742, SNP_A-1668371, SNP_A-1720828, SNP_A-2111731, SNP_A-1865177, SNP_A-1929912, SNP_A-2247916, SNP_A-4236931, SNP_A-4244073, SNP_A-2259134, SNP_A-2037440, SNP_A-8366470, SNP_A-4258044, SNP_A-4207457, SNP_A-1714265, SNP_A-2004736, SNP_A-1756708, SNP_A-1732136, SNP_A-1657677, SNP_A-1671537, SNP_A-1715812, SNP_A-1721138, SNP_A-2314533, SNP_A-8323516, SNP_A-1804779, SNP_A-8408734, SNP_A-4256449, SNP_A-8366301, SNP_A-2227539, SNP_A-1827845, SNP_A-2004753, SNP_A-1919920, SNP_A-4196146, SNP_A-1835380, SNP_A-2199128, SNP_A-2079650, SNP_A-1890751, SNP_A-1818267, SNP_A-2103044, SNP_A-2254741, SNP_A-2116587, SNP_A-4257505, SNP_A-1809191, SNP_A-2190270, SNP_A-2004784, SNP_A-1720096, SNP_A-1727316, SNP_A-1653143, SNP_A-1709246, SNP_A-1719592, SNP_A-1654200, SNP_A-1673385, SNP_A-1733395, SNP_A-1665679, SNP_A-1727273, SNP_A-1728980, SNP_A-1732294, SNP_A-1670086, SNP_A-1811302, SNP_A-4299613, SNP_A-1698671, SNP_A-4286127, SNP_A-1651948, SNP_A-8563890, SNP_A-1741687, SNP_A-1706397, SNP_A-2072861, SNP_A-1759010, SNP_A-1705029, SNP_A-1734894, SNP_A-1722114, SNP_A-1805576, SNP_A-1821013, SNP_A-2062415, SNP_A-1866309, SNP_A-1939367, SNP_A-2135197, SNP_A-2249033, SNP_A-4260557, SNP_A-2214759, SNP_A-4300601, SNP_A-2253258, SNP_A-8402476, SNP_A-8291071, SNP_A-8686552, SNP_A-1854494, SNP_A-1900074, SNP_A-8616578, SNP_A-2149277, SNP_A-2157543, SNP_A-2124731, SNP_A-8625667, SNP_A-2214673, SNP_A-1723135, SNP_A-1726833, SNP_A-1664617, SNP_A-1709636, SNP_A-2280865, SNP_A-4196344, SNP_A-2205844, SNP_A-2276600, SNP_A-2264250, SNP_A-1815898, SNP_A-2178028, SNP_A-1832997, SNP_A-1874537, SNP_A-1791198, SNP_A-1824415, SNP_A-1918540, SNP_A-2243186, SNP_A-2170496, SNP_A-1750321, SNP_A-1664262, SNP_A-1694439, SNP_A-1663970, SNP_A-1687612, SNP_A-1698036, SNP_A-1712170, SNP_A-1737354, SNP_A-1740402, SNP_A-1655255, SNP_A-1699485, SNP_A-1737097, SNP_A-1718102, SNP_A-1706822, SNP_A-4235301, SNP_A-1652012,

SNP_A-1738665, SNP_A-1684846, SNP_A-1677048, SNP_A-4246807, SNP_A-1747301, SNP_A-1737111, SNP_A-1702003, SNP_A-1900824, SNP_A-1697048, SNP_A-1722340, SNP_A-1720397, SNP_A-1865990, SNP_A-1757972, SNP_A-1708709, SNP_A-1736479, SNP_A-2192882, SNP_A-1673938, SNP_A-1675596, SNP_A-1673860, SNP_A-1659486, SNP_A-1711514, SNP_A-1660109, SNP_A-1758475, SNP_A-1720999, SNP_A-1689574, SNP_A-1747837, SNP_A-1650226, SNP_A-1649852, SNP_A-4276462, SNP_A-1716439, SNP_A-2158708, SNP_A-2306790, SNP_A-1721563, SNP_A-1734261, SNP_A-1707810, SNP_A-2024761, SNP_A-1726943, SNP_A-1664347, SNP_A-2311980, SNP_A-1692732, SNP_A-1745812, SNP_A-1657675, SNP_A-1700233, SNP_A-1664324, SNP_A-1734092, SNP_A-2245335, SNP_A-1650195, SNP_A-4274710, SNP_A-1667383, SNP_A-1725341, SNP_A-2293077, SNP_A-1753185, SNP_A-1835847, SNP_A-2088563, SNP_A-1933153, SNP_A-8398136, SNP_A-2251706, SNP_A-1928242, SNP_A-2160809, SNP_A-2115350, SNP_A-1751708, SNP_A-1688778, SNP_A-1752055, SNP_A-1716810, SNP_A-1698493, SNP_A-1705294, SNP_A-1759020, SNP_A-1653957, SNP_A-1703006, SNP_A-2111908, SNP_A-1906259, SNP_A-1875782, SNP_A-1857203, SNP_A-1689024, SNP_A-4297635, SNP_A-1939715, SNP_A-1833672, SNP_A-1798460, SNP_A-1862736, SNP_A-1854968, SNP_A-1833939, SNP_A-2212271, SNP_A-1883575, SNP_A-1847789, SNP_A-4236325, SNP_A-4203247, SNP_A-2106028, SNP_A-1850669, SNP_A-2118867, SNP_A-4221198, SNP_A-2234364, SNP_A-2158776, SNP_A-1902898, SNP_A-8582700, SNP_A-8373718, SNP_A-2214038, SNP_A-2154493, SNP_A-8406188, SNP_A-1689066, SNP_A-1743191, SNP_A-1684528, SNP_A-1713370, SNP_A-1668492, SNP_A-1719313, SNP_A-8696776, SNP_A-1735316, SNP_A-8659897, SNP_A-8364096, SNP_A-1723220, SNP_A-8470039, SNP_A-2025385, SNP_A-2070247, SNP_A-4242389, SNP_A-4233346, SNP_A-1660418, SNP_A-1657831, SNP_A-1648513, SNP_A-1666775, SNP_A-1675695, SNP_A-1727952, SNP_A-1659277, SNP_A-1708055, SNP_A-1709876, SNP_A-2054674, SNP_A-1923022, SNP_A-1799789, SNP_A-2026973, SNP_A-1862762, SNP_A-1847734, SNP_A-2032854, SNP_A-1815188, SNP_A-1909423, SNP_A-1712223, SNP_A-1670906, SNP_A-1753575, SNP_A-1718533,

SNP_A-1711524, SNP_A-1653568, SNP_A-1677682, SNP_A-1730433, SNP_A-1694763, SNP_A-1714455, SNP_A-1649568, SNP_A-1724848, SNP_A-1719505, SNP_A-1711076, SNP_A-1685394, SNP_A-1690529, SNP_A-1740719, SNP_A-1752119, SNP_A-2141857, SNP_A-1704648, SNP_A-1684580, SNP_A-1669263, SNP_A-1696420, SNP_A-1758929, SNP_A-1688502, SNP_A-1743201, SNP_A-1734921, SNP_A-1741520, SNP_A-2269705, SNP_A-4248305, SNP_A-1865131, SNP_A-1695390, SNP_A-1750962, SNP_A-1642404, SNP_A-1692865, SNP_A-1740212, SNP_A-1746826, SNP_A-1753998, SNP_A-2279744, SNP_A-4196563, SNP_A-1884616, SNP_A-1681605, SNP_A-1651318, SNP_A-1642027, SNP_A-1682290, SNP_A-1706787, SNP_A-1682211, SNP_A-1735106, SNP_A-1671009, SNP_A-1673189, SNP_A-8311353, SNP_A-1842767, SNP_A-1681021, SNP_A-2159467, SNP_A-2302387, SNP_A-2096398, SNP_A-4250734, SNP_A-4243156, SNP_A-1720420, SNP_A-1727704, SNP_A-1653007, SNP_A-1660282, SNP_A-1663747, SNP_A-1653885, SNP_A-8679786, SNP_A-8361531, SNP_A-4290890, SNP_A-2038598, SNP_A-4288097, SNP_A-8423424, SNP_A-8437457, SNP_A-8622447, SNP_A-2120285, SNP_A-4300664, SNP_A-1844527, SNP_A-4251479, SNP_A-2081065, SNP_A-1672170, SNP_A-2177133, SNP_A-1757260, SNP_A-1922491, SNP_A-1646389, SNP_A-2207936, SNP_A-1755627, SNP_A-1755750, SNP_A-1683657, SNP_A-1661366, SNP_A-4248775, SNP_A-8374394, SNP_A-8517050, SNP_A-1694768, SNP_A-2267915, SNP_A-2260545, SNP_A-1801062, SNP_A-1727710, SNP_A-1827792, SNP_A-1944894, SNP_A-1681041, SNP_A-2149440, SNP_A-1672678, SNP_A-2252396, SNP_A-1722667, SNP_A-1724223, SNP_A-2191282, SNP_A-2165131, SNP_A-1952627, SNP_A-1661405, SNP_A-2049570, SNP_A-1664579, SNP_A-1834330, SNP_A-1904902, SNP_A-2145569, SNP_A-1717130, SNP_A-2113064, SNP_A-4223296, SNP_A-1852694, SNP_A-1644371, SNP_A-2204445, SNP_A-1745410, SNP_A-8357982, SNP_A-8486574, SNP_A-8319357, SNP_A-2212975, SNP_A-1795259, SNP_A-1689008, SNP_A-1660907, SNP_A-1699087, SNP_A-4250879, SNP_A-1698647, SNP_A-1748427, SNP_A-2073904, SNP_A-1689777, SNP_A-4247875, SNP_A-2176536, SNP_A-2027813, SNP_A-2179958, SNP_A-1648384, SNP_A-1701556, SNP_A-1745602, SNP_A-1704392,

SNP_A-1692789, SNP_A-1721869, SNP_A-1728906, SNP_A-1654330, SNP_A-1657741, SNP_A-4234608, SNP_A-2289953, SNP_A-4203326, SNP_A-1847689, SNP_A-2026942, SNP_A-1898649, SNP_A-4216119, SNP_A-2172972, SNP_A-1873397, SNP_A-1819036, SNP_A-4252000, SNP_A-4248130, SNP_A-4246527, SNP_A-2183298, SNP_A-1892854, SNP_A-1726468, SNP_A-1685490, SNP_A-1720687, SNP_A-1675225, SNP_A-1742545, SNP_A-1644288, SNP_A-2145640, SNP_A-4299232, SNP_A-1744478, SNP_A-1849790, SNP_A-2005143, SNP_A-4205260, SNP_A-1750708, SNP_A-1673371, SNP_A-2090991, SNP_A-1676967, SNP_A-2307676, SNP_A-1680651, SNP_A-1687289, SNP_A-1665875, SNP_A-1676583, SNP_A-1731028, SNP_A-1644562, SNP_A-1658100, SNP_A-1700409, SNP_A-2086566, SNP_A-1740700, SNP_A-1651870, SNP_A-2310304, SNP_A-2090300, SNP_A-8624766, SNP_A-4194109, SNP_A-4232768, SNP_A-1735570, SNP_A-1690968, SNP_A-1716045, SNP_A-1746390, SNP_A-1678758, SNP_A-1754001, SNP_A-1705605, SNP_A-1682922, SNP_A-2242850, SNP_A-1885717, SNP_A-2054110, SNP_A-1757409, SNP_A-1684071, SNP_A-4278344, SNP_A-1724991, SNP_A-2264040, SNP_A-4235936, SNP_A-1954688, SNP_A-2005155, SNP_A-1910492, SNP_A-1720794, SNP_A-2138860, SNP_A-1915932, SNP_A-2274795, SNP_A-1738376, SNP_A-8355783, SNP_A-8683400, SNP_A-4296415, SNP_A-1732134, SNP_A-8511192, SNP_A-8446759, SNP_A-1731414, SNP_A-1955613, SNP_A-1644216, SNP_A-1645794, SNP_A-1741973, SNP_A-1716895, SNP_A-1696594, SNP_A-1645275, SNP_A-1671611, SNP_A-1852994, SNP_A-1663046, SNP_A-1709147, SNP_A-1737910, SNP_A-1710259, SNP_A-1694463, SNP_A-1746885, SNP_A-1701579, SNP_A-4192755, SNP_A-1868452, SNP_A-2180105, SNP_A-4240621, SNP_A-4199749, SNP_A-4195857, SNP_A-2148860, SNP_A-1847585, SNP_A-4246116, SNP_A-8660035, SNP_A-8582980, SNP_A-2293901, SNP_A-8410451, SNP_A-2169640, SNP_A-4203320, SNP_A-2201934, SNP_A-2165576, SNP_A-1930336, SNP_A-4242758, SNP_A-1851304, SNP_A-1862708, SNP_A-1935311, SNP_A-1960132, SNP_A-1901709, SNP_A-1741892, SNP_A-8689569, SNP_A-8423814, SNP_A-1735770, SNP_A-1741100, SNP_A-2069996, SNP_A-2174835, SNP_A-1696725, SNP_A-1894450, SNP_A-2106664, SNP_A-1904893,

SNP_A-1687221, SNP_A-1697828, SNP_A-4247687, SNP_A-2083201, SNP_A-4247472, SNP_A-1744776, SNP_A-1836455, SNP_A-1751828, SNP_A-1728204, SNP_A-1786341, SNP_A-1704004, SNP_A-1749832, SNP_A-1668166, SNP_A-1647184, SNP_A-4195635, SNP_A-2087283, SNP_A-1744881, SNP_A-2132974, SNP_A-4205966, SNP_A-2046005, SNP_A-1856397, SNP_A-1921687, SNP_A-1668295, SNP_A-2173143, SNP_A-1834766, SNP_A-1730261, SNP_A-2144306, SNP_A-1752921, SNP_A-1856617, SNP_A-1716610, SNP_A-1666840, SNP_A-1898866, SNP_A-2212725, SNP_A-2199095, SNP_A-2136616, SNP_A-1856763, SNP_A-1751910, SNP_A-1695060, SNP_A-2257051, SNP_A-2296701, SNP_A-8500120, SNP_A-8312135, SNP_A-8396391, SNP_A-1827800, SNP_A-1876168, SNP_A-8710562, SNP_A-1857282, SNP_A-2051266, SNP_A-1781535, SNP_A-2292565, SNP_A-4206462, SNP_A-2240790, SNP_A-8486047, SNP_A-1793824, SNP_A-2100267, SNP_A-8567918, SNP_A-2022502, SNP_A-2228763, SNP_A-1858399, SNP_A-1861772, SNP_A-2043762, SNP_A-1787565, SNP_A-2021023, SNP_A-2205482, SNP_A-1817705, SNP_A-4199052, SNP_A-4221115, SNP_A-2048766, SNP_A-4253387, SNP_A-1859328, SNP_A-4247505, SNP_A-1708567, SNP_A-1712110, SNP_A-1742195, SNP_A-1742119, SNP_A-1697264, SNP_A-1699157, SNP_A-1657154, SNP_A-1699440, SNP_A-1697605, SNP_A-1688140, SNP_A-2237499, SNP_A-1859841, SNP_A-1883153, SNP_A-2212222, SNP_A-1747153, SNP_A-1694497, SNP_A-1646617, SNP_A-1757818, SNP_A-1664802, SNP_A-1656472, SNP_A-2026839, SNP_A-2173464, SNP_A-8468300, SNP_A-2311766, SNP_A-2214884, SNP_A-2204435, SNP_A-8395199, SNP_A-8395909, SNP_A-2047041, SNP_A-8402273, SNP_A-8707733, SNP_A-4250616, SNP_A-1681916, SNP_A-1737507, SNP_A-1723926, SNP_A-1690151, SNP_A-1694935, SNP_A-2038632, SNP_A-1754292, SNP_A-1862636, SNP_A-4251305, SNP_A-1655977, SNP_A-1742660, SNP_A-1670730, SNP_A-1663708, SNP_A-1711682, SNP_A-1715749, SNP_A-1694504, SNP_A-1748768, SNP_A-2102588, SNP_A-1692037, SNP_A-1701921, SNP_A-1749804, SNP_A-1655469, SNP_A-1675211, SNP_A-2096949, SNP_A-2242238, SNP_A-1915127, SNP_A-2099053, SNP_A-2181339, SNP_A-2151862, SNP_A-1730696, SNP_A-1866191, SNP_A-1665339, SNP_A-2242012,

SNP_A-1674736, SNP_A-1678485, SNP_A-1679955, SNP_A-1738127, SNP_A-1677323, SNP_A-1682911, SNP_A-1648429, SNP_A-1650123, SNP_A-1669440, SNP_A-2309791, SNP_A-4243701, SNP_A-4244679, SNP_A-4279365, SNP_A-1866397, SNP_A-1912906, SNP_A-1660514, SNP_A-1652427, SNP_A-1731118, SNP_A-1689217, SNP_A-2061016, SNP_A-1643138, SNP_A-1699730, SNP_A-1695888, SNP_A-2255094, SNP_A-1935828, SNP_A-2289526, SNP_A-8651927, SNP_A-8408358, SNP_A-2240932, SNP_A-2060532, SNP_A-4201798, SNP_A-2081967, SNP_A-1914091, SNP_A-1947916, SNP_A-1706815, SNP_A-1711674, SNP_A-2163257, SNP_A-1746198, SNP_A-1732558, SNP_A-1682228, SNP_A-1745304, SNP_A-1657818, SNP_A-2242179, SNP_A-8716235, SNP_A-8308644, SNP_A-8573375, SNP_A-8541698, SNP_A-1677898, SNP_A-8399802, SNP_A-2112946, SNP_A-2115385, SNP_A-2188508, SNP_A-4260262, SNP_A-4226164, SNP_A-1865755, SNP_A-8388028, SNP_A-1665348, SNP_A-1670644, SNP_A-4199913, SNP_A-1646978, SNP_A-1727925, SNP_A-1694703, SNP_A-1728345, SNP_A-1869819, SNP_A-1750765, SNP_A-1694421, SNP_A-1686212, SNP_A-1730657, SNP_A-1727625, SNP_A-1644516, SNP_A-8658782, SNP_A-1657778, SNP_A-1688096, SNP_A-1653619, SNP_A-2105003, SNP_A-1667449, SNP_A-4200002, SNP_A-4200005, SNP_A-1704294, SNP_A-1746109, SNP_A-1751610, SNP_A-1745909, SNP_A-1680957, SNP_A-2281893, SNP_A-2051876, SNP_A-1746988, SNP_A-1676559, SNP_A-1682091, SNP_A-1685429, SNP_A-1688899, SNP_A-2315010, SNP_A-8318321, SNP_A-1659305, SNP_A-1667823, SNP_A-8455325, SNP_A-1720460, SNP_A-8643578, SNP_A-1726057, SNP_A-1651499, SNP_A-2112814, SNP_A-1747748, SNP_A-1682641, SNP_A-1728034, SNP_A-1735111, SNP_A-1666129, SNP_A-1732232, SNP_A-4200687, SNP_A-4233963, SNP_A-2005294, SNP_A-2251997, SNP_A-2176667, SNP_A-1872494, SNP_A-2081620, SNP_A-2168042, SNP_A-2290495, SNP_A-2238422, SNP_A-8360764, SNP_A-8521397, SNP_A-8433251, SNP_A-4253734, SNP_A-8396763, SNP_A-1873719, SNP_A-8414088, SNP_A-2223891, SNP_A-2264408, SNP_A-1908087, SNP_A-2152263, SNP_A-4198664, SNP_A-4235381, SNP_A-1795972, SNP_A-8362020, SNP_A-1663467, SNP_A-1715580, SNP_A-8558721, SNP_A-1719574, SNP_A-1751240,

SNP_A-1753162, SNP_A-2179348, SNP_A-4196593, SNP_A-1755839, SNP_A-8680511, SNP_A-2265558, SNP_A-1895369, SNP_A-1741767, SNP_A-1656605, SNP_A-1809735, SNP_A-1651966, SNP_A-4240033, SNP_A-1894284, SNP_A-2106093, SNP_A-2231978, SNP_A-2209402, SNP_A-1839322, SNP_A-1783956, SNP_A-4294606, SNP_A-1683281, SNP_A-1717593, SNP_A-4295365, SNP_A-8645106, SNP_A-1671619, SNP_A-2301425, SNP_A-4281325, SNP_A-1671992, SNP_A-4199117, SNP_A-1753675, SNP_A-1756387, SNP_A-1743752, SNP_A-2306504, SNP_A-2093288, SNP_A-2069138, SNP_A-1952129, SNP_A-2310566, SNP_A-1699035, SNP_A-1755526, SNP_A-1924531, SNP_A-2259235, SNP_A-8358806, SNP_A-8496414, SNP_A-8447927, SNP_A-8484472, SNP_A-4249338, SNP_A-4282185, SNP_A-1647264, SNP_A-2112041, SNP_A-1757273, SNP_A-1751176, SNP_A-1752922, SNP_A-1668514, SNP_A-1716427, SNP_A-1731420, SNP_A-2053450, SNP_A-2217855, SNP_A-1683153, SNP_A-1725477, SNP_A-1732302, SNP_A-1661347, SNP_A-1669776, SNP_A-1787964, SNP_A-1897753, SNP_A-2161089, SNP_A-2182436, SNP_A-2180532, SNP_A-1700022, SNP_A-1688565, SNP_A-1668665, SNP_A-1677371, SNP_A-1836575, SNP_A-1873712, SNP_A-2166402, SNP_A-2126465, SNP_A-1817323, SNP_A-2005389, SNP_A-1819323, SNP_A-1720222, SNP_A-1652921, SNP_A-1646367, SNP_A-1669616, SNP_A-2073842, SNP_A-1665159, SNP_A-1675733, SNP_A-1717856, SNP_A-2005407, SNP_A-1666771, SNP_A-1671579, SNP_A-4200812, SNP_A-1740697, SNP_A-1741299, SNP_A-1880426, SNP_A-1747547, SNP_A-1715845, SNP_A-1690356, SNP_A-1751193, SNP_A-1681550, SNP_A-2029198, SNP_A-1900351, SNP_A-1724572, SNP_A-1647257, SNP_A-1741195, SNP_A-1750067, SNP_A-1717302, SNP_A-1757881, SNP_A-1698505, SNP_A-1696849, SNP_A-1754220, SNP_A-1754691, SNP_A-1647607, SNP_A-1690822, SNP_A-1920645, SNP_A-1890869, SNP_A-1707915, SNP_A-8521678, SNP_A-1647747, SNP_A-1656734, SNP_A-1907445, SNP_A-1728281, SNP_A-1705988, SNP_A-1684497, SNP_A-1955418, SNP_A-1691537, SNP_A-1678318, SNP_A-1662562, SNP_A-4228026, SNP_A-1688923, SNP_A-1744163, SNP_A-1709365, SNP_A-2233617, SNP_A-1709220, SNP_A-1654699, SNP_A-1694270, SNP_A-1699450, SNP_A-1727841, SNP_A-1714406,

SNP_A-1686919, SNP_A-1692309, SNP_A-1692688, SNP_A-1737624, SNP_A-1664180, SNP_A-1678887, SNP_A-1737216, SNP_A-1667799, SNP_A-1669089, SNP_A-1691892, SNP_A-1674881, SNP_A-1700521, SNP_A-1659624, SNP_A-1754130, SNP_A-1730339, SNP_A-1749130, SNP_A-4201096, SNP_A-1738486, SNP_A-1744772, SNP_A-1748552, SNP_A-1674480, SNP_A-1673795, SNP_A-2064076, SNP_A-1729999, SNP_A-1671113, SNP_A-1714984, SNP_A-1651505, SNP_A-1660040, SNP_A-1748826, SNP_A-1683199, SNP_A-1736182, SNP_A-1680743, SNP_A-1686295, SNP_A-1735035, SNP_A-1665666, SNP_A-2168411, SNP_A-1753553, SNP_A-1698925, SNP_A-1654055, SNP_A-1667550, SNP_A-1732391, SNP_A-1672071, SNP_A-1710464, SNP_A-1724815, SNP_A-1680181, SNP_A-1734635, SNP_A-1738135, SNP_A-1741634, SNP_A-1677703, SNP_A-1683209, SNP_A-1734109, SNP_A-1666573, SNP_A-1655248, SNP_A-1886228, SNP_A-8681355, SNP_A-1656274, SNP_A-1659893, SNP_A-8532588, SNP_A-8330811, SNP_A-1943233, SNP_A-1910820, SNP_A-4297945, SNP_A-2059676, SNP_A-1655490, SNP_A-1901966, SNP_A-1714952, SNP_A-1646179, SNP_A-1700154, SNP_A-1706824, SNP_A-1646817, SNP_A-1662711, SNP_A-1666299, SNP_A-1667423, SNP_A-1756234, SNP_A-1647947, SNP_A-1662999, SNP_A-1724000, SNP_A-1717324, SNP_A-1646661, SNP_A-2243875, SNP_A-2116009, SNP_A-1885732, SNP_A-8289609, SNP_A-1709726, SNP_A-1654548, SNP_A-1692140, SNP_A-1708242, SNP_A-4245852, SNP_A-4228059, SNP_A-1888628, SNP_A-1888647, SNP_A-1644935, SNP_A-4235841, SNP_A-4234962, SNP_A-8654183, SNP_A-8423087, SNP_A-8488001, SNP_A-4249981, SNP_A-1753444, SNP_A-4285658, SNP_A-1657854, SNP_A-4225295, SNP_A-8514517, SNP_A-1747394, SNP_A-1677145, SNP_A-4223468, SNP_A-1731955, SNP_A-1733223, SNP_A-1667271, SNP_A-1646396, SNP_A-1836464, SNP_A-2005492, SNP_A-2147683, SNP_A-4276052, SNP_A-2071754, SNP_A-1658490, SNP_A-4214496, SNP_A-8355633, SNP_A-1732796, SNP_A-1866352, SNP_A-2035575, SNP_A-1901841, SNP_A-2133261, SNP_A-4224934, SNP_A-1833911, SNP_A-2154281, SNP_A-1870572, SNP_A-2173250, SNP_A-1891741, SNP_A-1858576, SNP_A-1930174, SNP_A-1824446, SNP_A-2047975, SNP_A-2270299, SNP_A-1669068, SNP_A-1714432,

SNP_A-1704778, SNP_A-1713605, SNP_A-2062856, SNP_A-2260082, SNP_A-1751384, SNP_A-1684693, SNP_A-1719744, SNP_A-1649761, SNP_A-1659994, SNP_A-1694180, SNP_A-1739614, SNP_A-1679703, SNP_A-1688581, SNP_A-2228341, SNP_A-1820250, SNP_A-8474819, SNP_A-4281242, SNP_A-8406100, SNP_A-4202188, SNP_A-2048929, SNP_A-1671125, SNP_A-1678585, SNP_A-1734565, SNP_A-1721406, SNP_A-1662561, SNP_A-2053300, SNP_A-1751776, SNP_A-1642678, SNP_A-1697121, SNP_A-2176708, SNP_A-1743702, SNP_A-4207428, SNP_A-1750852, SNP_A-1676939, SNP_A-1684013, SNP_A-1743416, SNP_A-1747138, SNP_A-1682027, SNP_A-1685547, SNP_A-1727518, SNP_A-1739306, SNP_A-1642376, SNP_A-1687725, SNP_A-1740494, SNP_A-1683041, SNP_A-1675629, SNP_A-1715918, SNP_A-1893035, SNP_A-1666195, SNP_A-1682075, SNP_A-1677721, SNP_A-1730938, SNP_A-1658595, SNP_A-2311400, SNP_A-1664629, SNP_A-1718534, SNP_A-1655270, SNP_A-1649289, SNP_A-1703388, SNP_A-1729923, SNP_A-1666039, SNP_A-1713355, SNP_A-1659899, SNP_A-1661929, SNP_A-1701792, SNP_A-1756009, SNP_A-1647769, SNP_A-1825745, SNP_A-1697722, SNP_A-1686709, SNP_A-1695490, SNP_A-1806508, SNP_A-1751484, SNP_A-2252811, SNP_A-2287881, SNP_A-4255059, SNP_A-4247637, SNP_A-1697251, SNP_A-1749506, SNP_A-1738412, SNP_A-1643701, SNP_A-1656102, SNP_A-1699298, SNP_A-1693091, SNP_A-1683873, SNP_A-4223320, SNP_A-1732848, SNP_A-2036778, SNP_A-1700081, SNP_A-1903756, SNP_A-1706737, SNP_A-1682870, SNP_A-1704051, SNP_A-1745434, SNP_A-1683646, SNP_A-1704875, SNP_A-1679119, SNP_A-1739000, SNP_A-1676843, SNP_A-1754105, SNP_A-1688478, SNP_A-1698934, SNP_A-1682720, SNP_A-1647268, SNP_A-1709979, SNP_A-1758554, SNP_A-1665262, SNP_A-1650614, SNP_A-4196338, SNP_A-2104652, SNP_A-4197173, SNP_A-1710281, SNP_A-1650716, SNP_A-1744315, SNP_A-1732338, SNP_A-1712524, SNP_A-1717498, SNP_A-1652287, SNP_A-1661194, SNP_A-1684185, SNP_A-1667610, SNP_A-1651756, SNP_A-1739339, SNP_A-1745856, SNP_A-1652102, SNP_A-1739153, SNP_A-1906609, SNP_A-1649086, SNP_A-1661245, SNP_A-1675176, SNP_A-1724793, SNP_A-1956506, SNP_A-1907327, SNP_A-2107375, SNP_A-8399680, SNP_A-1852440,

SNP_A-4297909, SNP_A-8519074, SNP_A-2030704, SNP_A-2122191, SNP_A-1909234, SNP_A-2162153, SNP_A-2280033, SNP_A-4254703, SNP_A-2107068, SNP_A-2171068, SNP_A-1789579, SNP_A-1888655, SNP_A-1838597, SNP_A-1836819, SNP_A-4257526, SNP_A-1855785, SNP_A-2284356, SNP_A-8561216, SNP_A-2203275, SNP_A-8672213, SNP_A-8702305, SNP_A-8435301, SNP_A-1941039, SNP_A-1916061, SNP_A-1698832, SNP_A-4256758, SNP_A-1753004, SNP_A-8522055, SNP_A-1787919, SNP_A-2073348, SNP_A-2247294, SNP_A-2031461, SNP_A-1944924, SNP_A-4268886, SNP_A-2005711, SNP_A-1918911, SNP_A-2070372, SNP_A-2140501, SNP_A-8568186, SNP_A-8497629, SNP_A-1919330, SNP_A-1648688, SNP_A-1657249, SNP_A-1658860, SNP_A-1651622, SNP_A-1756791, SNP_A-1697677, SNP_A-1695708, SNP_A-1682877, SNP_A-1735305, SNP_A-1739514, SNP_A-1668746, SNP_A-1837099, SNP_A-2053948, SNP_A-1857952, SNP_A-1925462, SNP_A-1827599, SNP_A-1830253, SNP_A-4257657, SNP_A-1823379, SNP_A-1829586, SNP_A-1875028, SNP_A-1709068, SNP_A-1754477, SNP_A-1696339, SNP_A-1723715, SNP_A-1722074, SNP_A-1687542, SNP_A-1656361, SNP_A-2167458, SNP_A-2031100, SNP_A-2129594, SNP_A-1850617, SNP_A-2025334, SNP_A-1685575, SNP_A-1736260, SNP_A-1746471, SNP_A-1752228, SNP_A-1678229, SNP_A-1719187, SNP_A-1656821, SNP_A-1679366, SNP_A-1645148, SNP_A-1721039, SNP_A-1679626, SNP_A-1689799, SNP_A-1669551, SNP_A-1680408, SNP_A-1933165, SNP_A-1894522, SNP_A-1648298, SNP_A-1708637, SNP_A-1652030, SNP_A-1935243, SNP_A-1704041, SNP_A-2216448, SNP_A-2029601, SNP_A-4205811, SNP_A-4201806, SNP_A-8644360, SNP_A-1871088, SNP_A-1752531, SNP_A-4258524, SNP_A-1686931, SNP_A-1746537, SNP_A-1658693, SNP_A-1665769, SNP_A-1658182, SNP_A-1647465, SNP_A-1713966, SNP_A-1646587, SNP_A-1702800, SNP_A-1912822, SNP_A-1684153, SNP_A-1694610, SNP_A-1652184, SNP_A-1704674, SNP_A-1748003, SNP_A-1679792, SNP_A-1654959, SNP_A-1717645, SNP_A-2115822, SNP_A-2032186, SNP_A-1875897, SNP_A-1784097, SNP_A-1679530, SNP_A-1686044, SNP_A-1694301, SNP_A-1720413, SNP_A-1692546, SNP_A-1668412, SNP_A-1707747, SNP_A-1685710, SNP_A-1715903, SNP_A-2199328, SNP_A-1742852,

SNP_A-1756653, SNP_A-1743183, SNP_A-4223695, SNP_A-1757216, SNP_A-1729341, SNP_A-2215253, SNP_A-1711154, SNP_A-1668579, SNP_A-1677241, SNP_A-1657620, SNP_A-2099368, SNP_A-1874512, SNP_A-1659221, SNP_A-2146029, SNP_A-1664125, SNP_A-8509279, SNP_A-4242445, SNP_A-1788376, SNP_A-2228209, SNP_A-2306324, SNP_A-1878513, SNP_A-2039520, SNP_A-2233178, SNP_A-1657667, SNP_A-1715362, SNP_A-1705593, SNP_A-2023432, SNP_A-1914276, SNP_A-4259059, SNP_A-1702852, SNP_A-4278466, SNP_A-2096459, SNP_A-1721414, SNP_A-2079792, SNP_A-2063652, SNP_A-2173616, SNP_A-4233938, SNP_A-1676844, SNP_A-1792488, SNP_A-1720032, SNP_A-1727605, SNP_A-1690484, SNP_A-1697936, SNP_A-1758880, SNP_A-1725387, SNP_A-1727534, SNP_A-1652775, SNP_A-1864543, SNP_A-1820156, SNP_A-1937678, SNP_A-1752051, SNP_A-1727040, SNP_A-1662532, SNP_A-1745101, SNP_A-1723549, SNP_A-1653105, SNP_A-1832467, SNP_A-1914434, SNP_A-4229265, SNP_A-1867027, SNP_A-4289288, SNP_A-2134977, SNP_A-2124117, SNP_A-2104501, SNP_A-1883518, SNP_A-1834452, SNP_A-1695988, SNP_A-1940393, SNP_A-1898491, SNP_A-2239226, SNP_A-4198917, SNP_A-1874251, SNP_A-2051235, SNP_A-1687507, SNP_A-2150128, SNP_A-2247869, SNP_A-1896614, SNP_A-1753028, SNP_A-1644359, SNP_A-1689656, SNP_A-1750892, SNP_A-2289580, SNP_A-2021427, SNP_A-2117341, SNP_A-2101950, SNP_A-2192947, SNP_A-4297829, SNP_A-1812367, SNP_A-4301596, SNP_A-1800760, SNP_A-2049426, SNP_A-1790539, SNP_A-2260465, SNP_A-4232819, SNP_A-2155070, SNP_A-2246120, SNP_A-1943740, SNP_A-1684761, SNP_A-4288399, SNP_A-4245667, SNP_A-2212873, SNP_A-2150556, SNP_A-2278558, SNP_A-4277992, SNP_A-1716183, SNP_A-1655367, SNP_A-2312685, SNP_A-8497182, SNP_A-2005887, SNP_A-1955669, SNP_A-2228115, SNP_A-2080894, SNP_A-4245481, SNP_A-2089778, SNP_A-1738114, SNP_A-2149322, SNP_A-2021394, SNP_A-4292557, SNP_A-2279700, SNP_A-1796023, SNP_A-1780401, SNP_A-2081064, SNP_A-1683610, SNP_A-2177148, SNP_A-1750747, SNP_A-1690537, SNP_A-1738142, SNP_A-1680722, SNP_A-1743997, SNP_A-1738306, SNP_A-4226947, SNP_A-1946519, SNP_A-4199168, SNP_A-1900238, SNP_A-1900095, SNP_A-2090195,

SNP_A-1666632, SNP_A-2197258, SNP_A-1737347, SNP_A-1666484, SNP_A-1674108, SNP_A-2234716, SNP_A-1899437, SNP_A-2262872, SNP_A-4294347, SNP_A-1903576, SNP_A-2300910, SNP_A-2101686, SNP_A-2303508, SNP_A-2097961, SNP_A-1720055, SNP_A-2063078, SNP_A-2173507, SNP_A-1806970, SNP_A-1848692, SNP_A-1752909, SNP_A-1683302, SNP_A-1748399, SNP_A-1663486, SNP_A-1669441, SNP_A-2106406, SNP_A-2295704, SNP_A-4216622, SNP_A-2285116, SNP_A-4242689, SNP_A-2283623, SNP_A-1646064, SNP_A-1734538, SNP_A-1655566, SNP_A-1662145, SNP_A-1729902, SNP_A-1682581, SNP_A-4224717, SNP_A-1648482, SNP_A-1653046, SNP_A-1667839, SNP_A-2205167, SNP_A-1723130, SNP_A-2288961, SNP_A-1671448, SNP_A-1756551, SNP_A-1712335, SNP_A-1646418, SNP_A-1650774, SNP_A-1758362, SNP_A-1663769, SNP_A-4223322, SNP_A-2239931, SNP_A-1706650, SNP_A-1721273, SNP_A-2296975, SNP_A-1717562, SNP_A-1646531, SNP_A-1695074, SNP_A-1713189, SNP_A-1736617, SNP_A-4283613, SNP_A-4242847, SNP_A-2088126, SNP_A-1672930, SNP_A-1705085, SNP_A-4286302, SNP_A-2095049, SNP_A-1797799, SNP_A-1877961, SNP_A-1713229, SNP_A-1723540, SNP_A-1644402, SNP_A-1669813, SNP_A-1736347, SNP_A-1645604, SNP_A-1666276, SNP_A-2263193, SNP_A-1724294, SNP_A-2231708, SNP_A-1681886, SNP_A-1713167, SNP_A-1667748, SNP_A-1740951, SNP_A-4233470, SNP_A-1715787, SNP_A-1667456, SNP_A-1696852, SNP_A-1666054, SNP_A-1792316, SNP_A-2176834, SNP_A-1833116, SNP_A-1743303, SNP_A-1684056, SNP_A-1739349, SNP_A-2070323, SNP_A-1678144, SNP_A-1733284, SNP_A-1937436, SNP_A-2169876, SNP_A-2041862, SNP_A-2115324, SNP_A-1865619, SNP_A-1955626, SNP_A-4217070, SNP_A-2150973, SNP_A-1717007, SNP_A-4207232, SNP_A-2191007, SNP_A-1871081, SNP_A-2167434, SNP_A-1940529, SNP_A-1956434, SNP_A-1663830, SNP_A-1698697, SNP_A-1692334, SNP_A-1702237, SNP_A-1713490, SNP_A-4246590, SNP_A-2141716, SNP_A-4294254, SNP_A-2230690, SNP_A-1961195, SNP_A-4271854, SNP_A-2177278, SNP_A-1847808, SNP_A-4234917, SNP_A-1794306, SNP_A-4228935, SNP_A-2195267, SNP_A-2146654, SNP_A-2108737, SNP_A-8304979, SNP_A-8564067, SNP_A-1898329, SNP_A-1878385, SNP_A-1787142,

SNP_A-1893970, SNP_A-8627555, SNP_A-2175951, SNP_A-8543685, SNP_A-1807215, SNP_A-2246371, SNP_A-2183305, SNP_A-2191595, SNP_A-2087148, SNP_A-2263288, SNP_A-2167765, SNP_A-2048981, SNP_A-2196426, SNP_A-1906659, SNP_A-2150726, SNP_A-1694367, SNP_A-2182802, SNP_A-1696942, SNP_A-1701735, SNP_A-1650678, SNP_A-1722466, SNP_A-1667768, SNP_A-1664674, SNP_A-1697102, SNP_A-2114627, SNP_A-4284443, SNP_A-4261348, SNP_A-2285867, SNP_A-2108061, SNP_A-2181803, SNP_A-2289478, SNP_A-4201380, SNP_A-2078460, SNP_A-1661091, SNP_A-2005988, SNP_A-1846920, SNP_A-1811871, SNP_A-1736971, SNP_A-1658782, SNP_A-4223809, SNP_A-1743639, SNP_A-1654585, SNP_A-1710455, SNP_A-1717833, SNP_A-1705587, SNP_A-1714683, SNP_A-1946842, SNP_A-4290591, SNP_A-1730763, SNP_A-2216251, SNP_A-1877275, SNP_A-2082607, SNP_A-2238609, SNP_A-1679035, SNP_A-4257553, SNP_A-2050306, SNP_A-2308145, SNP_A-4300123, SNP_A-2234073, SNP_A-4292851, SNP_A-2063509, SNP_A-4275423, SNP_A-1654653, SNP_A-1945141, SNP_A-1732206, SNP_A-1675452, SNP_A-8554796, SNP_A-1680821, SNP_A-2144795, SNP_A-1873371, SNP_A-8419960, SNP_A-1961664, SNP_A-2089221, SNP_A-1735099, SNP_A-1743362, SNP_A-1734069, SNP_A-1722933, SNP_A-2229856, SNP_A-2045559, SNP_A-2222661, SNP_A-1660098, SNP_A-1668978, SNP_A-4230722, SNP_A-4222845, SNP_A-2220960, SNP_A-2311777, SNP_A-1914058, SNP_A-1840239, SNP_A-1663755, SNP_A-2254286, SNP_A-8611335, SNP_A-8326674, SNP_A-2222254, SNP_A-1835728, SNP_A-2289010, SNP_A-1841906, SNP_A-1736968, SNP_A-1664343, SNP_A-2188127, SNP_A-1661939, SNP_A-1665677, SNP_A-2201682, SNP_A-1697187, SNP_A-1744618, SNP_A-4200487, SNP_A-1751766, SNP_A-1948379, SNP_A-2121939, SNP_A-1816161, SNP_A-1927622, SNP_A-1827575, SNP_A-1961713, SNP_A-1809429, SNP_A-2263070, SNP_A-4227728, SNP_A-2245131, SNP_A-2201527, SNP_A-2269750, SNP_A-1709657, SNP_A-1662036, SNP_A-1717823, SNP_A-8334383, SNP_A-1717901, SNP_A-1646906, SNP_A-1681394, SNP_A-1871847, SNP_A-2225929, SNP_A-2288951, SNP_A-2284411, SNP_A-1912934, SNP_A-2212655, SNP_A-1805122, SNP_A-2162637, SNP_A-1662908, SNP_A-8687084, SNP_A-8435048,

SNP_A-8469848, SNP_A-1901165, SNP_A-1808126, SNP_A-1801723, SNP_A-4239165, SNP_A-4207791, SNP_A-1817332, SNP_A-1671467, SNP_A-1715270, SNP_A-2160506, SNP_A-1838343, SNP_A-1661199, SNP_A-4193549, SNP_A-2221680, SNP_A-1705388, SNP_A-1705976, SNP_A-4202400, SNP_A-1673886, SNP_A-1697743, SNP_A-1706627, SNP_A-1645690, SNP_A-4251057, SNP_A-1815062, SNP_A-1884262, SNP_A-1733468, SNP_A-1718444, SNP_A-1748725, SNP_A-1733064, SNP_A-2245014, SNP_A-1658206, SNP_A-1709256, SNP_A-1819136, SNP_A-4277292, SNP_A-2218994, SNP_A-4299905, SNP_A-2276373, SNP_A-1854033, SNP_A-8559313, SNP_A-2168395, SNP_A-2276280, SNP_A-1669428, SNP_A-4238000, SNP_A-1730843, SNP_A-4296198, SNP_A-1655167, SNP_A-1702909, SNP_A-1659077, SNP_A-2311692, SNP_A-1654694, SNP_A-1809989, SNP_A-1715626, SNP_A-1646717, SNP_A-1655716, SNP_A-1678257, SNP_A-1660338, SNP_A-2304181, SNP_A-1719826, SNP_A-2193570, SNP_A-4248673, SNP_A-2107037, SNP_A-1646447, SNP_A-1650069, SNP_A-1698440, SNP_A-1703676, SNP_A-1843100, SNP_A-2060360, SNP_A-1647343, SNP_A-1699664, SNP_A-1706526, SNP_A-1664109, SNP_A-4247152, SNP_A-1673331, SNP_A-2069295, SNP_A-2239790, SNP_A-4204071, SNP_A-1782210, SNP_A-2294539, SNP_A-4280073, SNP_A-1780487, SNP_A-4269113, SNP_A-4233112, SNP_A-2030069, SNP_A-1731032, SNP_A-2219702, SNP_A-1716148, SNP_A-8433799, SNP_A-1877888, SNP_A-4274417, SNP_A-2107990, SNP_A-1725623, SNP_A-2152469, SNP_A-1659863, SNP_A-1719620, SNP_A-1650469, SNP_A-1651549, SNP_A-1691367, SNP_A-1701904, SNP_A-1744980, SNP_A-8395361, SNP_A-1757716, SNP_A-1685511, SNP_A-1749994, SNP_A-1655282, SNP_A-8697656, SNP_A-2056367, SNP_A-1755841, SNP_A-1695756, SNP_A-1702884, SNP_A-1753888, SNP_A-2113809, SNP_A-8556776, SNP_A-2090485, SNP_A-4195229, SNP_A-1787520, SNP_A-2219262, SNP_A-1680452, SNP_A-1727122, SNP_A-1668478, SNP_A-1726100, SNP_A-1706835, SNP_A-1657009, SNP_A-1655813, SNP_A-1724222, SNP_A-1690513, SNP_A-1701319, SNP_A-1644144, SNP_A-1714398, SNP_A-1729676, SNP_A-1704945, SNP_A-1757816, SNP_A-1644520, SNP_A-1726944, SNP_A-1685392, SNP_A-1746174, SNP_A-1755882, SNP_A-1684174,

SNP_A-1753921, SNP_A-1715157, SNP_A-8335853, SNP_A-1967739, SNP_A-8331001, SNP_A-8577715, SNP_A-8362035, SNP_A-1820687, SNP_A-1643693, SNP_A-1710186, SNP_A-1691735, SNP_A-1728670, SNP_A-1739310, SNP_A-1668491, SNP_A-1701672, SNP_A-1705652, SNP_A-1711865, SNP_A-1655428, SNP_A-1709446, SNP_A-1654272, SNP_A-2007392, SNP_A-4225456, SNP_A-8567326, SNP_A-8517108, SNP_A-1704930, SNP_A-1752194, SNP_A-1874112, SNP_A-1683613, SNP_A-1744548, SNP_A-1691265, SNP_A-1738370, SNP_A-1755863, SNP_A-1701136, SNP_A-1643128, SNP_A-1739018, SNP_A-1678797, SNP_A-1737987, SNP_A-1744418, SNP_A-1675707, SNP_A-1684503, SNP_A-1668191, SNP_A-1678877, SNP_A-1662953, SNP_A-1655226, SNP_A-1659017, SNP_A-1680341, SNP_A-1680881, SNP_A-2096082, SNP_A-1722473, SNP_A-4282023, SNP_A-1812829, SNP_A-1647189, SNP_A-1732829, SNP_A-2225117, SNP_A-1934192, SNP_A-1792143, SNP_A-2152908, SNP_A-1645708, SNP_A-2198071, SNP_A-1654405, SNP_A-1667370, SNP_A-1705967, SNP_A-1742509, SNP_A-1677980, SNP_A-2287747, SNP_A-1722130, SNP_A-1696380, SNP_A-1694518, SNP_A-1642861, SNP_A-1681866, SNP_A-1664235, SNP_A-1671275, SNP_A-1696186, SNP_A-1704441, SNP_A-1748235, SNP_A-2224435, SNP_A-1730945, SNP_A-1709836, SNP_A-1642524, SNP_A-1698268, SNP_A-1748846, SNP_A-2026590, SNP_A-1726155, SNP_A-1648103, SNP_A-2091783, SNP_A-1660652, SNP_A-1642028, SNP_A-1647589, SNP_A-1752096, SNP_A-1757524, SNP_A-8314011, SNP_A-1695206, SNP_A-8655605, SNP_A-4241264, SNP_A-2097463, SNP_A-8569540, SNP_A-2263320, SNP_A-1968161, SNP_A-2262848, SNP_A-8440876, SNP_A-1686219, SNP_A-1693187, SNP_A-1748574, SNP_A-1678387, SNP_A-1734237, SNP_A-1786600, SNP_A-1679043, SNP_A-1679509, SNP_A-1730331, SNP_A-1749852, SNP_A-1690838, SNP_A-1671320, SNP_A-1683786, SNP_A-1688066, SNP_A-1644140, SNP_A-1681152, SNP_A-1656913, SNP_A-1716827, SNP_A-1736667, SNP_A-1667937, SNP_A-1721196, SNP_A-1968211, SNP_A-1643157, SNP_A-1728378, SNP_A-4287424, SNP_A-1745256, SNP_A-1683645, SNP_A-1716873, SNP_A-1903595, SNP_A-8628692, SNP_A-8488531, SNP_A-8649812, SNP_A-1968227, SNP_A-1645640, SNP_A-2089685, SNP_A-1756411,

SNP_A-1739983, SNP_A-1652982, SNP_A-2220088, SNP_A-2314783, SNP_A-1655822, SNP_A-4304444, SNP_A-1741909, SNP_A-1645373, SNP_A-1734459, SNP_A-1650951, SNP_A-2222914, SNP_A-1843999, SNP_A-1803380, SNP_A-2121443, SNP_A-2282290, SNP_A-2231443, SNP_A-1661675, SNP_A-1719304, SNP_A-4276380, SNP_A-8635668, SNP_A-2102560, SNP_A-4242979, SNP_A-4246010, SNP_A-8356994, SNP_A-8611599, SNP_A-4297036, SNP_A-4280289, SNP_A-8521838, SNP_A-4251722, SNP_A-1649874, SNP_A-1954515, SNP_A-1894039, SNP_A-2007601, SNP_A-1694469, SNP_A-1713732, SNP_A-1722812, SNP_A-1941535, SNP_A-1650254, SNP_A-1656989, SNP_A-4224410, SNP_A-1654359, SNP_A-1789855, SNP_A-2054336, SNP_A-1691812, SNP_A-1666438, SNP_A-2041883, SNP_A-1746801, SNP_A-2274321, SNP_A-1844073, SNP_A-1704439, SNP_A-1732884, SNP_A-1698217, SNP_A-1671446, SNP_A-1738957, SNP_A-1669783, SNP_A-1659020, SNP_A-1735691, SNP_A-1917817, SNP_A-1732772, SNP_A-1859061, SNP_A-2241981, SNP_A-1659628, SNP_A-1670596, SNP_A-1698573, SNP_A-1813379, SNP_A-1684592, SNP_A-2007647, SNP_A-2045150, SNP_A-1665546, SNP_A-2173314, SNP_A-2156645, SNP_A-1927805, SNP_A-2037240, SNP_A-2277585, SNP_A-1959229, SNP_A-1683250, SNP_A-1655467, SNP_A-2191860, SNP_A-1670269, SNP_A-2280053, SNP_A-1689731, SNP_A-1758772, SNP_A-1929751, SNP_A-1701299, SNP_A-1721924, SNP_A-1644636, SNP_A-1666344, SNP_A-1880210, SNP_A-1711374, SNP_A-1833357, SNP_A-2114025, SNP_A-2202877, SNP_A-1968507, SNP_A-1864897, SNP_A-1704671, SNP_A-1688774, SNP_A-1678370, SNP_A-8484850, SNP_A-1954855, SNP_A-2093922, SNP_A-2068424, SNP_A-1718025, SNP_A-8551751, SNP_A-1937797, SNP_A-1739967, SNP_A-1887283, SNP_A-2125065, SNP_A-1958348, SNP_A-1745940, SNP_A-1728465, SNP_A-1655735, SNP_A-2189674, SNP_A-1968566, SNP_A-4257745, SNP_A-2007723, SNP_A-2109269, SNP_A-2174132, SNP_A-4200236, SNP_A-8320526, SNP_A-1968583, SNP_A-1854899, SNP_A-1855282, SNP_A-8625918, SNP_A-2007739, SNP_A-1941446, SNP_A-4229517, SNP_A-2144305, SNP_A-2226955, SNP_A-4222435, SNP_A-2068112, SNP_A-4300462, SNP_A-8486717, SNP_A-2184716, SNP_A-1743963, SNP_A-4293777, SNP_A-1664572,

SNP_A-4232264, SNP_A-1751601, SNP_A-1705409, SNP_A-1679336, SNP_A-1711302, SNP_A-1758073, SNP_A-1739947, SNP_A-1663721, SNP_A-1677485, SNP_A-2081258, SNP_A-4197768, SNP_A-1705014, SNP_A-1754171, SNP_A-2310589, SNP_A-8434103, SNP_A-1644079, SNP_A-1691343, SNP_A-1703514, SNP_A-1683391, SNP_A-1693994, SNP_A-1742612, SNP_A-1674526, SNP_A-4220271, SNP_A-1717807, SNP_A-1728137, SNP_A-1730451, SNP_A-1698025, SNP_A-1722858, SNP_A-1693809, SNP_A-1692802, SNP_A-1676106, SNP_A-1677440, SNP_A-1716137, SNP_A-1757871, SNP_A-1731599, SNP_A-1735866, SNP_A-1674047, SNP_A-1714361, SNP_A-1666097, SNP_A-2296198, SNP_A-1644171, SNP_A-1656458, SNP_A-1925263, SNP_A-1677029, SNP_A-2264720, SNP_A-2007808, SNP_A-1656636, SNP_A-1704844, SNP_A-1752548, SNP_A-1645401, SNP_A-1718924, SNP_A-2194042, SNP_A-1660574, SNP_A-2067396, SNP_A-1869509, SNP_A-1751394, SNP_A-1698862, SNP_A-1755939, SNP_A-1690845, SNP_A-1660774, SNP_A-2007841, SNP_A-2159370, SNP_A-1789298, SNP_A-1645387, SNP_A-4299800, SNP_A-1903193, SNP_A-1968847, SNP_A-1681043, SNP_A-1737028, SNP_A-1738916, SNP_A-1680099, SNP_A-1648559, SNP_A-1688627, SNP_A-1653314, SNP_A-1758473, SNP_A-1703755, SNP_A-1695261, SNP_A-1678512, SNP_A-1730895, SNP_A-4287186, SNP_A-1654448, SNP_A-1677458, SNP_A-1684579, SNP_A-1686263, SNP_A-1688363, SNP_A-1674859, SNP_A-2285054, SNP_A-1748779, SNP_A-4201267, SNP_A-2195244, SNP_A-8564963, SNP_A-1692074, SNP_A-1702295, SNP_A-1749637, SNP_A-1660585, SNP_A-2206351, SNP_A-1757091, SNP_A-2267168, SNP_A-1652917, SNP_A-1658181, SNP_A-2223324, SNP_A-1698559, SNP_A-4241259, SNP_A-1866638, SNP_A-2178933, SNP_A-2194757, SNP_A-1758391, SNP_A-2208037, SNP_A-1968935, SNP_A-2007909, SNP_A-8340055, SNP_A-2015118, SNP_A-8340065, SNP_A-1644380, SNP_A-2015124, SNP_A-4215521, SNP_A-2015126, SNP_A-4270134, SNP_A-2015139, SNP_A-4270136, SNP_A-4270137, SNP_A-1728394, SNP_A-1664767, SNP_A-4270141, SNP_A-1707818, SNP_A-1649176, SNP_A-2015284, SNP_A-1755856, SNP_A-1678280, SNP_A-1756445, SNP_A-1731086, SNP_A-1679429, SNP_A-4215557, SNP_A-2015464, SNP_A-1723659, SNP_A-2015476,

SNP_A-1969111, SNP_A-1677609, SNP_A-2015503, SNP_A-2015504, SNP_A-1731920, SNP_A-1721020, SNP_A-1723241, SNP_A-1691030, SNP_A-1672756, SNP_A-1662781, SNP_A-2015621, SNP_A-2015632, SNP_A-2015711, SNP_A-4270195, SNP_A-2015718, SNP_A-2015722, SNP_A-1741685, SNP_A-1649382, SNP_A-1719627, SNP_A-1722950, SNP_A-1733838, SNP_A-1679544, SNP_A-2015906, SNP_A-2015935, SNP_A-1647104, SNP_A-1755326, SNP_A-1730869, SNP_A-1673061, SNP_A-1706509, SNP_A-1729303, SNP_A-1650602, SNP_A-1665157, SNP_A-1671877, SNP_A-1730111, SNP_A-1752994, SNP_A-1731367, SNP_A-1683723, SNP_A-1659202, SNP_A-1716865, SNP_A-1666584, SNP_A-1728301, SNP_A-1662583, SNP_A-1665369, SNP_A-1692261, SNP_A-2016304, SNP_A-1969383, SNP_A-1656417, SNP_A-1672816, SNP_A-1738132, SNP_A-2016493, SNP_A-2016523, SNP_A-1969476, SNP_A-2016598, SNP_A-2016626, SNP_A-1969573, SNP_A-4215724, SNP_A-1726192, SNP_A-1722528, SNP_A-1705913, SNP_A-1647874, SNP_A-1736677, SNP_A-1692573, SNP_A-1742952, SNP_A-1748156, SNP_A-1674612, SNP_A-1666761, SNP_A-1718224, SNP_A-1722359, SNP_A-1659875, SNP_A-1687948, SNP_A-4270315, SNP_A-4270317, SNP_A-1688738, SNP_A-1754542, SNP_A-1687674, SNP_A-1733344, SNP_A-1660399, SNP_A-1742241, SNP_A-1969686, SNP_A-1664149, SNP_A-1720318, SNP_A-1730868, SNP_A-1717734, SNP_A-1961269, SNP_A-1732711, SNP_A-1682840, SNP_A-1734500, SNP_A-1698155, SNP_A-1660105, SNP_A-1749203, SNP_A-1733538, SNP_A-1659138, SNP_A-1667152, SNP_A-1758611, SNP_A-1688166, SNP_A-1744963, SNP_A-1706187, SNP_A-1732676, SNP_A-4270356, SNP_A-2017586, SNP_A-8338792, SNP_A-4270365, SNP_A-2017703, SNP_A-2017750, SNP_A-1969983, SNP_A-2018004, SNP_A-2280651, SNP_A-8341239, SNP_A-2018102, SNP_A-8497775, SNP_A-8438311, SNP_A-2018159, SNP_A-2018168, SNP_A-2018169, SNP_A-2018181, SNP_A-1658047, SNP_A-1716992, SNP_A-2018213, SNP_A-1655456, SNP_A-1665839, SNP_A-1732202, SNP_A-1736362, SNP_A-1728116, SNP_A-8342744, SNP_A-8578510, SNP_A-1970081, SNP_A-2018388, SNP_A-1923354, SNP_A-1674574, SNP_A-4214730, SNP_A-1683267, SNP_A-2008055, SNP_A-2018403, SNP_A-2018407, SNP_A-1737626, SNP_A-1673769,

SNP_A-1715992, SNP_A-1719670, SNP_A-1655956, SNP_A-1664401, SNP_A-2018475, SNP_A-4263047, SNP_A-2018481, SNP_A-2018491, SNP_A-2018493, SNP_A-2018632, SNP_A-2018638, SNP_A-2018645, SNP_A-8339511, SNP_A-1694216, SNP_A-2018757, SNP_A-1754127, SNP_A-1644967, SNP_A-1687133, SNP_A-8339854, SNP_A-4215889, SNP_A-2008070, SNP_A-2018808, SNP_A-2018824, SNP_A-4303085, SNP_A-8340225, SNP_A-1970243, SNP_A-1970244, SNP_A-1693852, SNP_A-1642330, SNP_A-1694482, SNP_A-1743446, SNP_A-1676595, SNP_A-1670096, SNP_A-1726525, SNP_A-1733465, SNP_A-1669456, SNP_A-1674608, SNP_A-1722285, SNP_A-1684259, SNP_A-1694934, SNP_A-1745553, SNP_A-1723932, SNP_A-1748929, SNP_A-1699457, SNP_A-1718399, SNP_A-1719567, SNP_A-1664244, SNP_A-2019401, SNP_A-2019403, SNP_A-2019410, SNP_A-2019414, SNP_A-1664794, SNP_A-1750268, SNP_A-1678045, SNP_A-1687089, SNP_A-1693992, SNP_A-2019503, SNP_A-1673097, SNP_A-1725867, SNP_A-1738529, SNP_A-1691700, SNP_A-1755022, SNP_A-1729473, SNP_A-1731448, SNP_A-1667192, SNP_A-1677176, SNP_A-2019715, SNP_A-1712494, SNP_A-1739092, SNP_A-1741976, SNP_A-4215966, SNP_A-1726017, SNP_A-1721789, SNP_A-1662883, SNP_A-1705048, SNP_A-1717234, SNP_A-1735817, SNP_A-1682512, SNP_A-1716894, SNP_A-1655030, SNP_A-1754354, SNP_A-1645229, SNP_A-2020206, SNP_A-1699116, SNP_A-2020210, SNP_A-2120280, SNP_A-1683706, SNP_A-1750873, SNP_A-1687757, SNP_A-1743789, SNP_A-1642129, SNP_A-1756960, SNP_A-1758903, SNP_A-1694876, SNP_A-1679874, SNP_A-1687715, SNP_A-1737068, SNP_A-1660603, SNP_A-2020368, SNP_A-2020390, SNP_A-1658680, SNP_A-4270708, SNP_A-1677576, SNP_A-1656861, SNP_A-2020544, SNP_A-2020568, SNP_A-1732766, SNP_A-1669096, SNP_A-2020616, SNP_A-1721548, SNP_A-1661128, SNP_A-1663886, SNP_A-1663462, SNP_A-2020699, SNP_A-1680685, SNP_A-4263139, SNP_A-8326837, SNP_A-1665631, SNP_A-1725741, SNP_A-1692062, SNP_A-2020783, SNP_A-1660031, SNP_A-1970638, SNP_A-1713751, SNP_A-2020803, SNP_A-1970645, SNP_A-1755352, SNP_A-1715645, SNP_A-1651743, SNP_A-1663971, SNP_A-1696207, SNP_A-4273852, SNP_A-1921629, SNP_A-4269252, SNP_A-2037079, SNP_A-2308659,

SNP_A-2120950, SNP_A-2233321, SNP_A-1885747, SNP_A-2301854, SNP_A-1911390, SNP_A-1670378, SNP_A-1723363, SNP_A-1727123, SNP_A-1730275, SNP_A-1741582, SNP_A-2300564, SNP_A-2118341, SNP_A-2008195, SNP_A-1731830, SNP_A-1668045, SNP_A-1720934, SNP_A-1970726, SNP_A-4235384, SNP_A-2110718, SNP_A-1785624, SNP_A-2248591, SNP_A-2150279, SNP_A-1815943, SNP_A-1712444, SNP_A-1718206, SNP_A-1702890, SNP_A-2115484, SNP_A-1721058, SNP_A-2295799, SNP_A-1662241, SNP_A-1652945, SNP_A-1753616, SNP_A-1643084, SNP_A-1695236, SNP_A-1737656, SNP_A-1739404, SNP_A-1744382, SNP_A-1655052, SNP_A-1703658, SNP_A-1704606, SNP_A-2115802, SNP_A-4230344, SNP_A-1752490, SNP_A-4204831, SNP_A-1797548, SNP_A-2106853, SNP_A-1686021, SNP_A-1706186, SNP_A-1648730, SNP_A-1701029, SNP_A-1727996, SNP_A-1748539, SNP_A-1819389, SNP_A-1815376, SNP_A-1913468, SNP_A-4250760, SNP_A-1920582, SNP_A-1727997, SNP_A-1661947, SNP_A-1677718, SNP_A-2205128, SNP_A-1939913, SNP_A-2271712, SNP_A-1676865, SNP_A-2090302, SNP_A-2224808, SNP_A-1930191, SNP_A-1666021, SNP_A-1709100, SNP_A-2184799, SNP_A-1735808, SNP_A-4192708, SNP_A-1871982, SNP_A-1806029, SNP_A-1913725, SNP_A-1970815, SNP_A-2068453, SNP_A-4275762, SNP_A-2272953, SNP_A-1657370, SNP_A-1654836, SNP_A-1696772, SNP_A-1734852, SNP_A-2106654, SNP_A-1703703, SNP_A-1689354, SNP_A-1700434, SNP_A-1970855, SNP_A-2091597, SNP_A-1755812, SNP_A-2181087, SNP_A-1744429, SNP_A-1970871, SNP_A-1682582, SNP_A-1758634, SNP_A-2209882, SNP_A-1720707, SNP_A-1708909, SNP_A-1690718, SNP_A-1663835, SNP_A-1667693, SNP_A-1652671, SNP_A-1658271, SNP_A-1705464, SNP_A-1715830, SNP_A-1756239, SNP_A-1647387, SNP_A-1650985, SNP_A-1694108, SNP_A-1701270, SNP_A-1809022, SNP_A-2214308, SNP_A-1935950, SNP_A-1806825, SNP_A-4196469, SNP_A-4214741, SNP_A-4233918, SNP_A-1806960, SNP_A-2093800, SNP_A-1970923, SNP_A-2008247, SNP_A-2039567, SNP_A-2272295, SNP_A-2109223, SNP_A-2125044, SNP_A-4245943, SNP_A-1870701, SNP_A-2183515, SNP_A-1876330, SNP_A-1783481, SNP_A-2108220, SNP_A-1829575, SNP_A-2171853, SNP_A-1736296, SNP_A-1742942, SNP_A-1795014,

SNP_A-1681395, SNP_A-4258490, SNP_A-2227996, SNP_A-1707812, SNP_A-1730074, SNP_A-2150176, SNP_A-1744738, SNP_A-1753788, SNP_A-1681619, SNP_A-1698395, SNP_A-1745808, SNP_A-1682119, SNP_A-1740056, SNP_A-1723563, SNP_A-1729195, SNP_A-1725248, SNP_A-1749042, SNP_A-1664322, SNP_A-1677481, SNP_A-1733529, SNP_A-1737428, SNP_A-1664419, SNP_A-4260962, SNP_A-1717202, SNP_A-1800409, SNP_A-1664023, SNP_A-1667295, SNP_A-1650797, SNP_A-1659565, SNP_A-1680953, SNP_A-1669084, SNP_A-1804613, SNP_A-1711656, SNP_A-1746861, SNP_A-1752425, SNP_A-1743045, SNP_A-1704939, SNP_A-1680034, SNP_A-1729990, SNP_A-1732890, SNP_A-1749634, SNP_A-1754865, SNP_A-1691105, SNP_A-1734997, SNP_A-1743412, SNP_A-1676279, SNP_A-2192108, SNP_A-1689720, SNP_A-1669970, SNP_A-1675028, SNP_A-1667395, SNP_A-1740792, SNP_A-2103130, SNP_A-2102323, SNP_A-2091768, SNP_A-1920225, SNP_A-1890352, SNP_A-1691277, SNP_A-1815604, SNP_A-4299992, SNP_A-1747108, SNP_A-4257665, SNP_A-2220141, SNP_A-1783792, SNP_A-1806351, SNP_A-1729451, SNP_A-1665383, SNP_A-1674055, SNP_A-1726721, SNP_A-1647727, SNP_A-1660178, SNP_A-1681127, SNP_A-1667121, SNP_A-4224161, SNP_A-2224737, SNP_A-1831811, SNP_A-4288380, SNP_A-4201068, SNP_A-1655916, SNP_A-1733665, SNP_A-1666135, SNP_A-1719816, SNP_A-1652679, SNP_A-1701916, SNP_A-1709286, SNP_A-1848682, SNP_A-1842270, SNP_A-2310415, SNP_A-1905280, SNP_A-4255317, SNP_A-1753298, SNP_A-2086907, SNP_A-4275655, SNP_A-4288953, SNP_A-2199835, SNP_A-2008307, SNP_A-2059035, SNP_A-4245775, SNP_A-2091285, SNP_A-2310550, SNP_A-2202743, SNP_A-1850911, SNP_A-4249717, SNP_A-1796392, SNP_A-4246808, SNP_A-2293911, SNP_A-2026978, SNP_A-4231463, SNP_A-2205277, SNP_A-1808939, SNP_A-2146140, SNP_A-4242932, SNP_A-2192073, SNP_A-2264812, SNP_A-1971149, SNP_A-4240035, SNP_A-1793193, SNP_A-4298731, SNP_A-4255042, SNP_A-2258329, SNP_A-4274157, SNP_A-1692809, SNP_A-1889235, SNP_A-2284753, SNP_A-4223629, SNP_A-2025698, SNP_A-1737488, SNP_A-2300476, SNP_A-1907606, SNP_A-2077989, SNP_A-1732757, SNP_A-1749332, SNP_A-1684313, SNP_A-1678161, SNP_A-1742254, SNP_A-1670499,

SNP_A-1827017, SNP_A-2236762, SNP_A-1805818, SNP_A-4250682, SNP_A-2080202, SNP_A-2279940, SNP_A-2108173, SNP_A-1806209, SNP_A-4239647, SNP_A-1807290, SNP_A-8544221, SNP_A-1825582, SNP_A-1897203, SNP_A-1955034, SNP_A-8627932, SNP_A-4246152, SNP_A-8299685, SNP_A-8483731, SNP_A-8717239, SNP_A-8694590, SNP_A-8605863, SNP_A-1885524, SNP_A-4224828, SNP_A-1812589, SNP_A-1664084, SNP_A-2167400, SNP_A-2175177, SNP_A-1722344, SNP_A-2097661, SNP_A-1719133, SNP_A-1692099, SNP_A-1726747, SNP_A-1732096, SNP_A-1651039, SNP_A-1704908, SNP_A-1746738, SNP_A-1710085, SNP_A-1861664, SNP_A-4255004, SNP_A-2082372, SNP_A-4259973, SNP_A-4209234, SNP_A-8420477, SNP_A-4261647, SNP_A-8527413, SNP_A-4207841, SNP_A-8573367, SNP_A-8573209, SNP_A-4207752, SNP_A-4261659, SNP_A-4207887, SNP_A-4207767, SNP_A-4207806, SNP_A-1666553, SNP_A-1715750, SNP_A-4261587, SNP_A-1726331, SNP_A-1685712, SNP_A-1735899, SNP_A-4207823, SNP_A-4207892, SNP_A-1726272, SNP_A-1660936, SNP_A-1680848, SNP_A-1643847, SNP_A-1646007, SNP_A-1715285, SNP_A-1708565, SNP_A-4207827, SNP_A-1688287, SNP_A-1656924, SNP_A-1667173, SNP_A-1709020, SNP_A-1714355, SNP_A-1649173, SNP_A-2171450, SNP_A-2158252, SNP_A-2259168, SNP_A-1653395, SNP_A-1750936, SNP_A-1643633, SNP_A-1692639, SNP_A-8401743, SNP_A-8395497, SNP_A-8472391, SNP_A-2138007, SNP_A-1797683, SNP_A-4205940, SNP_A-1885223, SNP_A-1913592, SNP_A-8414083, SNP_A-8281357, SNP_A-8281362, SNP_A-8590296, SNP_A-8659190, SNP_A-8372680, SNP_A-8311543, SNP_A-2062151, SNP_A-8604368, SNP_A-8435500, SNP_A-8281803, SNP_A-8440961, SNP_A-4303359, SNP_A-8406566, SNP_A-8282242, SNP_A-8282243, SNP_A-8697424, SNP_A-1932696, SNP_A-8366871, SNP_A-8484396, SNP_A-8681160, SNP_A-8282684, SNP_A-1998287, SNP_A-8282685, SNP_A-4217780, SNP_A-8420105, SNP_A-8488612, SNP_A-2160571, SNP_A-8282709, SNP_A-8296545, SNP_A-8525896, SNP_A-8572486, SNP_A-4216090, SNP_A-2283155, SNP_A-8427715, SNP_A-8597855, SNP_A-8282725, SNP_A-8384745, SNP_A-8342171, SNP_A-8652267, SNP_A-8342173, SNP_A-8415201, SNP_A-8500975, SNP_A-1945234, SNP_A-8442081, SNP_A-8499838,

SNP_A-2064954, SNP_A-8328897, SNP_A-2075482, SNP_A-8673956, SNP_A-2286540, SNP_A-1820196, SNP_A-8484831, SNP_A-4282631, SNP_A-8686874, SNP_A-1998346, SNP_A-4267793, SNP_A-8645877, SNP_A-8394458, SNP_A-1998349, SNP_A-2127376, SNP_A-4235844, SNP_A-8367990, SNP_A-1668037, SNP_A-1721104, SNP_A-1705790, SNP_A-1642316, SNP_A-1656482, SNP_A-1699896, SNP_A-1754070, SNP_A-1814225, SNP_A-1878593, SNP_A-1998387, SNP_A-1846559, SNP_A-2102372, SNP_A-2133294, SNP_A-1998414, SNP_A-2140895, SNP_A-2145900, SNP_A-1695294, SNP_A-1751242, SNP_A-1739712, SNP_A-1670545, SNP_A-1674578, SNP_A-1753318, SNP_A-1647723, SNP_A-2126607, SNP_A-1830643, SNP_A-4196480, SNP_A-2309296, SNP_A-1868201, SNP_A-1998468, SNP_A-2120968, SNP_A-1712879, SNP_A-1660547, SNP_A-1656443, SNP_A-1747975, SNP_A-1643654, SNP_A-1757693, SNP_A-1684736, SNP_A-1690521, SNP_A-1744115, SNP_A-1749349, SNP_A-1680732, SNP_A-1724601, SNP_A-1732089, SNP_A-1737685, SNP_A-1649146, SNP_A-1676912, SNP_A-1695561, SNP_A-1739435, SNP_A-1734478, SNP_A-1749065, SNP_A-1665266, SNP_A-1665130, SNP_A-1710848, SNP_A-1688698, SNP_A-1738503, SNP_A-1845848, SNP_A-2014744, SNP_A-4287833, SNP_A-1998656, SNP_A-2150517, SNP_A-1817785, SNP_A-1799859, SNP_A-2197287, SNP_A-2266776, SNP_A-1998679, SNP_A-1786499, SNP_A-4238094, SNP_A-1843181, SNP_A-1842207, SNP_A-4234400, SNP_A-2078743, SNP_A-4221859, SNP_A-1681342, SNP_A-4295808, SNP_A-1688306, SNP_A-1644100, SNP_A-4202664, SNP_A-1649882, SNP_A-1662748, SNP_A-1727877, SNP_A-1748453, SNP_A-1680908, SNP_A-1687262, SNP_A-1646758, SNP_A-1648238, SNP_A-4230703, SNP_A-1687215, SNP_A-2054360, SNP_A-1659245, SNP_A-1668113, SNP_A-1795001, SNP_A-1658397, SNP_A-1663793, SNP_A-1737352, SNP_A-1739558, SNP_A-1844534, SNP_A-1747822, SNP_A-1881976, SNP_A-2014783, SNP_A-2026108, SNP_A-2104870, SNP_A-4238669, SNP_A-4261141, SNP_A-2072299, SNP_A-4231205, SNP_A-2193997, SNP_A-1860880, SNP_A-4279622, SNP_A-1801921, SNP_A-2098022, SNP_A-1865750, SNP_A-1956348, SNP_A-4267846, SNP_A-1855568, SNP_A-2287926, SNP_A-2168711, SNP_A-1732563, SNP_A-1998725, SNP_A-1663021,

SNP_A-1666631, SNP_A-1724897, SNP_A-1715028, SNP_A-1729443, SNP_A-1654574, SNP_A-1656474, SNP_A-1663259, SNP_A-4201876, SNP_A-8683448, SNP_A-2237476, SNP_A-8480912, SNP_A-8359336, SNP_A-4267856, SNP_A-2164102, SNP_A-8543903, SNP_A-8304523, SNP_A-2231066, SNP_A-1793622, SNP_A-2174052, SNP_A-8519950, SNP_A-8672187, SNP_A-8280993, SNP_A-8359758, SNP_A-8595933, SNP_A-8592654, SNP_A-1831148, SNP_A-8626836, SNP_A-8503148, SNP_A-8613138, SNP_A-8300905, SNP_A-8701615, SNP_A-1948403, SNP_A-8713677, SNP_A-4300994, SNP_A-2262347, SNP_A-8708376, SNP_A-8300789, SNP_A-2200648, SNP_A-8448700, SNP_A-8429831, SNP_A-8571725, SNP_A-8589997, SNP_A-8298112, SNP_A-4213750, SNP_A-2237226, SNP_A-2180812, SNP_A-8632969, SNP_A-1782913, SNP_A-4251425, SNP_A-4278864, SNP_A-2014811, SNP_A-8463009, SNP_A-8467063, SNP_A-8526684, SNP_A-8552827, SNP_A-4245060, SNP_A-8527339, SNP_A-8707771, SNP_A-2304338, SNP_A-2233417, SNP_A-1835372, SNP_A-2247194, SNP_A-4259371, SNP_A-1817494, SNP_A-2153816, SNP_A-4260463, SNP_A-2051523, SNP_A-1844503, SNP_A-8583104, SNP_A-8476978, SNP_A-1953540, SNP_A-8392710, SNP_A-8545364, SNP_A-8318880, SNP_A-8423201, SNP_A-1998944, SNP_A-1931630, SNP_A-8517235, SNP_A-8360741, SNP_A-2070428, SNP_A-4275879, SNP_A-8415246, SNP_A-2198187, SNP_A-1866297, SNP_A-8696895, SNP_A-1999031, SNP_A-8674924, SNP_A-4241695, SNP_A-8397090, SNP_A-1941946, SNP_A-8338631, SNP_A-8446973, SNP_A-8624336, SNP_A-8358961, SNP_A-8283633, SNP_A-8552059, SNP_A-8493025, SNP_A-1999035, SNP_A-8659634, SNP_A-2148389, SNP_A-8546438, SNP_A-8690440, SNP_A-8521736, SNP_A-1896112, SNP_A-2062292, SNP_A-4267897, SNP_A-8709382, SNP_A-2048848, SNP_A-4250703, SNP_A-8431013, SNP_A-1907325, SNP_A-4273283, SNP_A-1786253, SNP_A-2068741, SNP_A-2140780, SNP_A-2243723, SNP_A-1796711, SNP_A-1658086, SNP_A-1656953, SNP_A-1696560, SNP_A-1701433, SNP_A-1657950, SNP_A-1728195, SNP_A-1653230, SNP_A-1838510, SNP_A-1662700, SNP_A-1725662, SNP_A-1753701, SNP_A-1715445, SNP_A-4249944, SNP_A-1704085, SNP_A-1662546, SNP_A-1662732, SNP_A-1710277, SNP_A-2206146, SNP_A-8466510,

SNP_A-8387816, SNP_A-1928903, SNP_A-8561650, SNP_A-2129892, SNP_A-2121116, SNP_A-1999112, SNP_A-2045158, SNP_A-8284488, SNP_A-8466035, SNP_A-8552789, SNP_A-8478606, SNP_A-1999200, SNP_A-4213815, SNP_A-2232706, SNP_A-1934972, SNP_A-1999205, SNP_A-4278796, SNP_A-1999222, SNP_A-8534239, SNP_A-8524428, SNP_A-8402224, SNP_A-8368652, SNP_A-8365921, SNP_A-1904144, SNP_A-8422693, SNP_A-1803002, SNP_A-1807774, SNP_A-1794280, SNP_A-8511388, SNP_A-8395074, SNP_A-8364362, SNP_A-8339010, SNP_A-2289004, SNP_A-2294894, SNP_A-8339012, SNP_A-4258830, SNP_A-8415403, SNP_A-8560109, SNP_A-8295607, SNP_A-1925581, SNP_A-8707577, SNP_A-8457730, SNP_A-1819433, SNP_A-8371452, SNP_A-8444954, SNP_A-8404355, SNP_A-8347422, SNP_A-1816939, SNP_A-8701490, SNP_A-8636942, SNP_A-8686027, SNP_A-8588654, SNP_A-4275330, SNP_A-8515981, SNP_A-8545994, SNP_A-1999339, SNP_A-8476777, SNP_A-8659418, SNP_A-2014995, SNP_A-1879371, SNP_A-1807606, SNP_A-1999362, SNP_A-1949726, SNP_A-4200237, SNP_A-4201430, SNP_A-8659473, SNP_A-8632188, SNP_A-8317046, SNP_A-8407779, SNP_A-4278391, SNP_A-2090479, SNP_A-8636869, SNP_A-8539189, SNP_A-8522950, SNP_A-8528654, SNP_A-8588202, SNP_A-2288892, SNP_A-8298162, SNP_A-8717065, SNP_A-8453689, SNP_A-8404129, SNP_A-8527985, SNP_A-8561778, SNP_A-8406249, SNP_A-8534438, SNP_A-8417025, SNP_A-8317827, SNP_A-2107495, SNP_A-1902828, SNP_A-4267961, SNP_A-2066611, SNP_A-2116814, SNP_A-4283931, SNP_A-4248439, SNP_A-1999435, SNP_A-1942771, SNP_A-8567172, SNP_A-8485774, SNP_A-8598290, SNP_A-8411592, SNP_A-8425085, SNP_A-2113831, SNP_A-8561551, SNP_A-8486299, SNP_A-8461926, SNP_A-4222502, SNP_A-2188088, SNP_A-8554041, SNP_A-2148928, SNP_A-2213048, SNP_A-2167146, SNP_A-2081649, SNP_A-2208903, SNP_A-1746146, SNP_A-1742691, SNP_A-1689025, SNP_A-1738081, SNP_A-1647690, SNP_A-1723584, SNP_A-1699941, SNP_A-1738469, SNP_A-1757735, SNP_A-1697982, SNP_A-1751992, SNP_A-1737366, SNP_A-1815133, SNP_A-1678725, SNP_A-1680547, SNP_A-1959009, SNP_A-1715623, SNP_A-2308823, SNP_A-4239450, SNP_A-1999633, SNP_A-2057467, SNP_A-1864168, SNP_A-4304694,

SNP_A-4260595, SNP_A-2108728, SNP_A-1999636, SNP_A-1870919, SNP_A-2128033, SNP_A-1957192, SNP_A-2069036, SNP_A-4267990, SNP_A-2283915, SNP_A-8573210, SNP_A-8655052, SNP_A-8531037, SNP_A-8469844, SNP_A-8289944, SNP_A-8696345, SNP_A-8304442, SNP_A-8543775, SNP_A-8497077, SNP_A-8327985, SNP_A-8289987, SNP_A-8438520, SNP_A-8431909, SNP_A-8513100, SNP_A-8497683, SNP_A-8494982, SNP_A-8409837, SNP_A-8652810, SNP_A-8696561, SNP_A-8531226, SNP_A-8290004, SNP_A-8521579, SNP_A-8550793, SNP_A-8353823, SNP_A-8361499, SNP_A-8518383, SNP_A-8502405, SNP_A-8652403, SNP_A-8568099, SNP_A-8649666, SNP_A-8360329, SNP_A-8383167, SNP_A-8713092, SNP_A-8566304, SNP_A-8589367, SNP_A-8290007, SNP_A-8372352, SNP_A-8611867, SNP_A-8511719, SNP_A-8330416, SNP_A-8627092, SNP_A-8290012, SNP_A-8308145, SNP_A-8537348, SNP_A-8535072, SNP_A-8333138, SNP_A-8676343, SNP_A-8581506, SNP_A-8536948, SNP_A-8632067, SNP_A-8531760, SNP_A-8293961, SNP_A-8498269, SNP_A-8584255, SNP_A-8640091, SNP_A-8396630, SNP_A-8550103, SNP_A-8570506, SNP_A-8634599, SNP_A-8290019, SNP_A-8707909, SNP_A-8640704, SNP_A-8507820, SNP_A-8487177, SNP_A-8290264, SNP_A-8633789, SNP_A-8290267, SNP_A-8708617, SNP_A-8642739, SNP_A-8607809, SNP_A-8418205, SNP_A-8688109, SNP_A-8290277, SNP_A-8290278, SNP_A-8705225, SNP_A-8653199, SNP_A-8417266, SNP_A-8417375, SNP_A-8295972, SNP_A-8439392, SNP_A-8372528, SNP_A-8332143, SNP_A-8400249, SNP_A-8352188, SNP_A-8486463, SNP_A-8550815, SNP_A-8369683, SNP_A-8348747, SNP_A-8290283, SNP_A-8521142, SNP_A-8346444, SNP_A-8474444, SNP_A-8407770, SNP_A-8290290, SNP_A-8525311, SNP_A-8539904, SNP_A-8303472, SNP_A-8390603, SNP_A-8290291, SNP_A-8290292, SNP_A-8290293, SNP_A-8371607, SNP_A-8635714, SNP_A-8365189.

Se compararon los perfiles obtenidos en cada cromosoma (Figura 1 y 2) con arrays comerciales en series amplias de muestras (Tabla 6), tanto de nuestro laboratorio como de arrays de otros grupos, observándose la identificación de las alteraciones numéricas detectadas (Figura 3 y 4 número de copias analizadas en muestras de

meningiomas y análisis de muestras de gliomas y perfiles con el número de copias de diversos cromosomas, Figuras 5, 6, 7 y 8).

Tabla 6. Series de arrays analizados para establecer el contenido de nuestra invención (donde: ND es no depositado; Glioma (incluye bajo y alto grado), GBM es glioblastoma, SMD es síndrome mielodisplásico, LLC es leucemia linfática crónica, LLA: leucemia linfoblástica aguda y MM: mieloma múltiple).

PATOLOGIA

BASE INTERN. ARRAY MUESTRAS REFERENCIA

1 Meningioma

ND 500K 6.0SNP 50&7 Tabernero et al.Genes Chromosome&Cancer 2012,51:606

2 Meningioma

GSE16583 100K 82 Lee Y et al. Brain Pathol 2010,20(4):751

3 GBM

ND 500K 6.0SNP 35&26 Crespo et al. J Mol Diagn 2011,13,6:634. Plos One 2012,7(9):e46088

4 Glioma

ND 500K 28 Bralten LB et al.Genes Chromosome&Cancer 2010,49:509

5 GBM

GSE19612 250K 24 Chen R et al. Cancer Cell 2010,17:362

6 GBM

GSE19399 250K 19 Beroukhim R et al. Nature 2010,463:899

7 GBM

GSE14804 50K 12 Hodgson JG et al. NeuroOncology 2009;11(5):477

8 GBM

E-MEXP-1330 50K 500K 19&5 Yin D et al. Mol Cancer Res 2009,7:665

9 GBM

GSE10922 50K 14 Kuga D et al. NeuroOncology 2008,10(6):995

10 GBM

GSE13021 250K 30 Solomon DA et al. Cancer Res 2008,68(24):10300

12 Colon

GSE16125 250K 41 Reid JF et al. Genes Chromosome&Cancer 2009,48(11):953

13 Pulmón

GSE 34140 250K 17 Huang Y et al.

14 Mama

GSE7545 500K 15 Haverty PM et al. ChromosomesCancer 2008,47(6):530

15 Próstata

GSE18333 6.0SNP 5 Mao X et al.

Cancer Res 2010,70(13):5207

16 SMD

GSE19399 250K 6 Kilpivaara O et al. NatGenet 2009,41: 455

17 LLC

GSE16406 250K 164 Gunnarsson R et al. Leukemia 2010,24(1):211

18 LLA

GSE20353/ GSE9611 250K 500k 2/25 Kuiper RP et al/Paulsson K et al. Leukemia 2010, 24(7): 1258/ProcNatlAcadSci 2008,105(18):6708

19 MM

GSE31339 6.0SNP 34 Sarasquete M et al.

Base Intern.: Base internacional

MATERIALES Y MÉTODOS

5 El análisis del número de copias de muestras tumorales para conocer las alteraciones genéticas se realizo con ADN genómico (250ng) hibridado sobre arrays comerciales de la casa Affymetrix (Affymetrix Inc, Santa Clara, CA, USA) en dos series de enfermos de nuestro laboratorio: 50 pacientes con meningiomas y 35 glioblastomas con GeneChip Human Mapping 500K Array Set y 7 meningiomas y 26 GBM con

10 Genome-Wide Human SNP 6.0 Array. Además se analizó series de arrays de otros autores todos ellos con un porcentaje de llamadas mayor al 92%: 82 meningiomas (GSE 16583, que suman junto a nuestra serie un total de 139 arrays analizados), 8 series con gliomas (bajo y alto grado) (212 arrays), 78 arrays de 4 series de tumores sólidos (colon, pulmón, mama y próstata) y 231 tumores hematológicos: síndrome

15 mielodísplásico (SMD), leucemia linfática crónica (LLC), leucemia linfoblástica aguda (LLA) y mieloma múltiple (MM) (Tabla 6), depositados en repositorios públicos [Gene ExpressionOmnibus (GEO) del National Center of Biotechnology, USA y ArrayExpress Archive del European Molecular Biology Laboratory (EMBL) & European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, UK].

Los arrays utilizados (Affymetrix) y sus números de catálogo fueron: el GeneChip® Mapping 100K Set que contiene 100.000 sondas distribuidas en dos arrays, 520043 GeneChip Human Mapping 50K Array Xba y el 520044 GeneChip Human Mapping 50K Array Hind. El GeneChip Human Mapping 500K Array Set con información de 25 >500.000 sondas distribuidas en dos chips el GeneChip Human Mapping 250K Nsp Array referencia 900767 y 520331 GeneChip Human Mapping 250K Sty Array y

Genome-Wide Human SNP Array 6.0 con referencia 901182 que contiene más de 1,8 millones de sondas polimórficas y no polimórficas.

Los arrays se realizaron según el protocolo recomendado por el fabricante y conocido por el experto en la materia. Tras la hibridación, se lavaron los chips, se marcaron con biotina (GeneChip® DNA LabelingReagent), se escanearon usando GeneChip Scanner 3000 y 3000 G7 (Affymetrix Inc.) y se generaron los ficheros (.CEL que contienen la intensidad de cada sonda) con los programa Affymetrix® GeneChip® Operating Software (GCOS) y Affymetrix Command Console® Software (AGCC).

Los programa informáticos utilizados para el análisis fueron: GenotypingConsole software (versión 4.1.1.834; Affymetrix Inc.) y DNA-Chip Analyzer (dChip) software 2010, del Dana Farber Institute, Harvard, MA, USA para el cálculo de los valores del número de copias y su representación de acuerdo a la localización cromosómica. Los datos para cada sonda fueron extraídos del archivo CEL y convertidos en archivos CHP conocido por el experto en la materia. Se utilizaron los siguientes puntos de corte: para la pérdida de material genético valores ≤ 1,30 y para las ganancias cromosómicas valores ≥ 2,50. Las amplificaciones y deleciones homocigotas se establecieron cuando el número de copias era >5 para la amplificación génica y <0,8 copias para la deleción homocigota. En la construcción de los perfiles del número de copias y los idiogramas de cada cromosoma también se utilizó la versión 2.13.1 del programa R (software libre y lenguaje de programación para análisis estadístico y gráfico con comandos escritos ejecutados directamente y funciones estadísticas específicas para el análisis de arrays, contenidas dichas funciones en las llamadas librerías) y las herramientas de Bioconductor 2.8, ambos software libres y disponibles en la web. Se estableció el número de copias de cada cromosoma en los 139 arrays con meningiomas, 212 arrays con gliomas, 78 arrays de otros tumores sólidos y 231 tumores hematológicos (Tabla 6), detectando el tipo y extensión de las pérdidas y ganancias de material genético que afectaban a la totalidad de un cromosoma, uno de sus brazos, o deleciones intersticiales (homocigotas y/o heterocigotas) así como amplificaciones génicas.

Para identificar el menor número de sondas necesarias para nuestra invención, se utilizó el programa Copy Number Analyzer for Genechip (CNAG) 3.3.0.1(Beta),

Genome Laboratory, Universidad de Tokio-Japón siguiendo los siguientes pasos (Figura 9):

1)-Se localizaron todas las alteraciones y su extensión en cada cromosoma comenzando por las amplificaciones génicas y las deleciones homocigotas, seguidamente las deleciones heterocigotas y cualquier ganancia o pérdida intersticial y sus posiciones concretas en las regiones implicadas en enfermedades diferentes (Figura 2 y Tabla 6). Se seleccionaron las posiciones más distales de las regiones afectadas y los distintos tamaños de cada alteración para cubrir con sondas todas las regiones alteradas, que se localizaban dentro de genes y se evitaron las sondas redundantes. Las herramientas del programa nos muestran las posiciones físicas (inicio y fin) y las sondas implicadas.

2)-Se eliminaron sondas sin información incluidas en los arrays (sondas sin información de la posición física en ese cromosoma o sin gen asignado).

3)-Se eliminaron sondas de las regiones teloméricas y pericentroméricas para evitar hibridación cruzada entre los cromosomas 1, 5 y 19; el cromosoma 13 con el cromosoma 21; y el cromosoma 14 con el cromosoma 22.

4)-Se eliminaron las sondas con número de copias 2 (sondas sin alteraciones), como no informativas.

5)-Se seleccionaron sondas en todas las bandas cromosómicas para completar el perfil del cromosoma en toda su extensión.

6)-Finalmente, se confirmaron los resultados del array nuevo diseñado con representaciones graficas de los ideogramas de cada cromosoma comparando las sondas del nuevo diseño versus los dos arrays de alta densidad (más de 500.00 sondas) utilizados. Para ello se utilizó el programa R, versión 2.13.1 y la librería “quantsmooth” (librerías o paquete de funciones para el análisis y visualización de los idiogramas y las copias de cada sonda a lo largo de los cromosomas) disponible en el repositorio de Bioconductor que permite visualizar los datos del número de copias de forma gráfica en los cromosomas.

RESULTADOS

Los resultados mostraron que el método de la invención aún teniendo menor número

5 de sondas que los arrays comerciales de alta densidad, muestra igual resultado (detectamos las mismas alteraciones numéricas, ganancias y pérdidas de distintos tipos y extensión en los tumores recogidos en la tabla 6). Se identificaron las aneuploidías de cada cromosoma (cambios en el número de cromosomas) que afectaban a cromosomas completos monosomias y trisomías. Hemos establecido las

10 alteraciones recurrentes, definido sus características y establecido su impacto en el pronóstico tumoral. Encontramos que las monosomias, deleciones y ganancias aparecen en tumores benignos y malignos localizándose en los cromosomas 22, 1, 14, 6, 7 y 18 en los meningiomas y en los gliomas son más frecuentes las ganancias del cromosoma 7 con o sin amplificación del gen EGFR (existen 2 grupos de tumores

15 según presenten o no amplificación de este gen), con pérdidas simultaneas a nivel de 9p (homocigotas y heterocigotas) y pérdidas de cromosoma 10, alteraciones raramente encontradas en gliomas benignos; así como deleciones heterocigotas y otras amplificaciones génicas de distintas extensiones y localizaciones cromosómicas tanto en tumores sólidos como en neoplasias hematológicas, habiéndose conseguido

20 así un método más simple y optimizado que mantiene la especificidad y que resulta informativo para los 24 cromosomas de forma simultánea. Nuestros resultados avalan el método de la invención en diversas enfermedades genéticas: tumores del sistema nervioso, así como en otros tumores sólidos y hematológicos. La comparación del array específico diseñado versus arrays de alta densidad muestra todas las

25 alteraciones encontradas con arrays de mayor tamaño (Figura 10).

El análisis de varias series de tumores permitió identificar sus alteraciones genéticas, confirmando los grupos de alteraciones, sus posiciones físicas (especialmente aquellas que son recurrentes), así como los genes que contienen, por tanto los

30 cambios numéricos (pérdidas y ganancias) serían útiles en la clasificación de estas patologías. El array se diseñó con el número mínimo de secuencias sin sondas redundantes, evitado las sondas situadas en regiones pericentroméricas y en los extremos cromosómicos y se registró la marca “FullChromaArray”® para nuestro diseño.

Claims (36)

1. REIVINDICACIONES

   1.

   Método in vitro de obtención de datos útiles para la detección y/o cuantificación de al menos una ganancia y/o pérdida cromosómica en una muestra aislada de un sujeto con una enfermedad genética, donde la detección se realiza en las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23, 1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25, 3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12,, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11, 6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14, 11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11, 16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11.

2. 2.

   Método según la reivindicación 1 donde la enfermedad genética es cáncer o una enfermedad congénita.

3. 3.

   Método según la reivindicación 2 donde el cáncer es cáncer del sistema nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemias linfáticas crónicas, leucemias linfáticas agudas, mieloma múltiple o un síndrome mielodisplásico.

4. 4.

   Método según la reivindicación 3 donde el cáncer del sistema nervioso central es glioma, meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme.

5. 5.

   Método según la reivindicación 2 donde la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.

6. 6.

   Método in vitro para el diagnóstico o pronóstico de una enfermedad genética o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética caracterizado por comprender los siguientes pasos:

   a. detectar y/o cuantificar al menos una ganancia y/o pérdida cromosómica en las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23, 1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25, 3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11, 6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14,

   11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11, 16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11 en una muestra aislada de un sujeto;

   b.

   comparar el número de copias de las regiones cromosómicas detectadas y/o cuantificadas en el paso (a) con niveles estándar;

   c.

   encontrar al menos una diferencia significativa en la comparación del paso (b);

   d.

   asociar la diferencia significativa del paso (c) a una ganancia o a una pérdida genética; y

   e.

   asociar las ganancias o pérdidas genéticas del paso (d) a una enfermedad genética.

7. 7.

   Método según la reivindicación 6 donde en el paso (d) y el paso (e) la ganancia o pérdida genética es una pérdida o ganancia de al menos un cromosoma entero, de al menos uno de los brazos de un cromosoma o de al menos una región cromosómica de al menos uno de los brazos de un cromosoma, donde la región cromosómica comprende al menos un gen.

8. 8.

   Método según cualquiera de las reivindicaciones 6 o 7 donde la detección y/o cuantificación del paso (a) se realiza mediante la detección y/o cuantificación de al menos un gen que se encuentre localizado en las regiones cromosómicas descritas en el paso (a).

9. 9.

   Método según la reivindicación 8 donde la detección y/o cuantificación del paso (a) se realiza mediante la detección y/o cuantificación de los genes de la tabla 1.
10. 10. Método según cualquiera de las reivindicaciones 6 a 9 donde la enfermedad

    genética es cáncer o una enfermedad congénita. 5
11. 11. Método según la reivindicación 10 donde el cáncer es cáncer del sistema nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemia linfática crónica, leucemia linfática aguda, mieloma múltiple o un síndrome mielodisplásico.
12. 12. Método según la reivindicación 11 donde el cáncer del sistema nervioso central es glioma, meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme.

    15 13. Método según la reivindicación 10 donde la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.
13. 14. Método según cualquiera de las reivindicaciones 1 a 13 donde la detección de la

    ganancia y/o pérdida cromosómica se realiza mediante hibridación con sondas de 20 ácido desoxirribonucléico.
14. 15. Método según la reivindicación 14 donde el número de sondas se sitúa entre
15. 10.000 y 20.000.

    25 16. Método según la reivindicación 15 donde el número de sondas se sitúa entre
16. 14.000 y 15.000.
17. 17. Método según cualquiera de las reivindicaciones 14 a 16 donde las sondas tienen

    entre 20 y 200 pares de bases. 30

18. 18.

    Método según cualquiera de las reivindicaciones 14 a 17 donde las sondas se sitúan en un soporte sólido.

19. 19.

    Método según la reivindicación 18 donde las sondas están marcadas con fluorocromos.

20. 20.

    Método según cualquiera de las reivindicaciones 1 a 19 donde la muestra se selecciona de la lista que comprende tejido, líquido cefalorraquídeo, mucosa oral, sangre, plasma, suero, linfa, liquido pleural y orina.

21. 21.

    Método según cualquiera de las reivindicaciones 1 a 20 donde el sujeto es un humano.

22. 22.

    Uso in vitro del número de copias de las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23, 1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25, 3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11, 6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14, 11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11,

    16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11 como marcador diagnóstico o pronóstico de enfermedades genéticas o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética.

23. 23.

    Uso según la reivindicación 22 donde la enfermedad genética es cáncer o una enfermedad congénita.

24. 24.

    Uso según la reivindicación 23 donde el cáncer es cáncer del sistema nervioso central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemia linfática crónica, leucemia linfática aguda, mieloma múltiple o un síndrome mielodisplásico.

25. 25.

    Uso según la reivindicación 24 donde el cáncer del sistema nervioso central es glioma, meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme.

26. 26.

    Uso según la reivindicación 23 donde la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.

27. 27.

    Array que comprende sondas que detectan ganancias y/o pérdidas de las regiones cromosómicas 1p36, 1p35, 1p34, 1p33, 1p32, 1p31, 1p22, 1p21, 1p13, 1p12, 1p11, 1q21, 1q22, 1q23, 1q24, 1q25, 1q31, 1q32, 1q41, 1q42, 1q43. 1q44, 2p25, 2p24, 2p23, 2p22, 2p21, 2p16, 2p15, 2p14, 2p13, 2p12, 2p11, 2q11, 2q12, 2q13, 2q14, 2q21, 2q22, 2q23, 2q24, 2q31, 2q32, 2q33, 2q34, 2q35, 2q36, 2q37, 3p26, 3p25, 3p24, 3p23, 3p22, 3p21, 3p14, 3p13, 3p12, 3p11, 3q11, 3q12, 3q13, 3q21, 3q22, 3q23, 3q24, 3q25, 3q26, 3q27, 3q28, 3q 29, 4p16, 4p15, 4p14, 4p13, 4p12, 4q12, 4q13, 4q21, 4q22, 4q23, 4q24, 4q25, 4q26, 4q27, 4q28, 4q31, 4q32, 4q33, 4q34, 4q35, 5p15, 5p14, 5p13, 5p12, 5q11, 5q12, 5q13, 5q14, 5q15, 5q21, 5q22, 5q23, 5q31, 5q32, 5q33, 5q34, 5q35, 6p25, 6p24, 6p23, 6p22, 6p21, 6p12, 6p11,

    6q11, 6q12, 6q13, 6q14, 6q15, 6q16, 6q21, 6q22, 6q23, 6q24, 6q25, 6q26, 6q27, 7p22, 7p21, 7p15, 7p14, 7p13, 7p12, 7p11, 7q11, 7q21, 7q22, 7q31, 7q32, 7q33, 7q34, 7q35, 7q36, 8p23, 8p22, 8p21, 8p12, 8p11, 8q11, 8q12, 8q13, 8q21, 8q22, 8q23, 8q24, 9p24, 9p23, 9p22, 9p21, 9p13, 9p12, 9p11, 9q12, 9q13, 9q21, 9q22, 5 9q31, 9q32, 9q33, 9q34, 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, 10q26, 11p15, 11p14, 11p13, 11p12, 11p11, 11q12, 11q13, 11q14, 11q21, 11q22, 11q23, 11q24, 11q25, 12p13, 12p12, 12p11, 12q12, 12q13, 12q14, 12q15, 12q21, 12q22, 12q23, 12q24, 13q12, 13q13, 13q14, 13q21, 13q22, 13q31, 13q32, 13q33, 13q34, 14q11, 14q12, 14q13, 14q21, 14q22, 14q23, 10 14q24, 14q31, 14q32, 15q11, 15q12, 15q13, 15q14, 15q15, 15q21, 15q22, 15q23, 15q24, 15q25, 15q26, 16p13, 16p12, 16p11, 16q11, 16q12, 16q13, 16q21, 16q22, 16q23, 16q24, 17p13, 17p12, 17p11, 17q11, 17q12, 17q21, 17q22, 17q23, 17q24, 17q25, 18p11, 18q11, 18q12, 18q21, 18q22, 18q23, 19p13, 19p12, 19q12, 19q13, 20p13, 20p12, 20p11, 20q11, 20q12, 20q13, 21q11, 21q21, 21q22, 22q11, 22q12, 15 22q13, Xp22, Xp21, Xp11, Xq11, Xq12, Xq13, Xq21, Xq22, Xq23, Xq24, Xq25, Xq26, Xq27, Xq28, Yp11 y Yq11 donde el número de dichas sondas se sitúa entre
28. 10.000 y 20.000; donde dichas sondas comprenden las sondas descritas en la tabla 5.

    20 28. Array según la reivindicación 27 donde el número de las sondas se sitúa entre
29. 12.000 y 15.000.
30. 29. Array según cualquiera de las reivindicaciones 27 a 28 donde las sondas se sitúan

    en un soporte sólido. 25

31. 30.

    Array según cualquiera de las reivindicaciones 27 a 29 donde las sondas detectan los genes de la tabla 1.

32. 31.

    Uso del array según cualquiera de las reivindicaciones 27 a 30 para el diagnóstico

    30 o pronóstico de enfermedades genéticas o para el diseño de un tratamiento personalizado en un sujeto con una enfermedad genética.

33. 32.

    Uso según la reivindicación 31 donde la enfermedad genética es cáncer o una enfermedad congénita.

34. 33.

    Uso según la reivindicación 32 donde el cáncer es cáncer del sistema nervioso

    5 central, cáncer de colon, cáncer de pulmón, cáncer de mama, cáncer de próstata, cáncer de vejiga, leucemia linfática crónica, leucemia linfática aguda, mieloma múltiple o un síndrome mielodisplásico.
35. 34. Uso según la reivindicación 33 donde el cáncer del sistema nervioso central es

    10 glioma, meningioma benigno, meningioma maligno, oligodendroglioma o glioblastoma multiforme.
36. 35. Uso según la reivindicación 32 donde la enfermedad congénita es síndrome de Down, síndrome de Edwards o síndrome de Patau.

    DIBUJOS

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