ES2458921B1 - Modelo animal de déficit cognitivo, procedimiento de obtención y aplicaciones - Google Patents
Modelo animal de déficit cognitivo, procedimiento de obtención y aplicaciones Download PDFInfo
- Publication number
- ES2458921B1 ES2458921B1 ES201231533A ES201231533A ES2458921B1 ES 2458921 B1 ES2458921 B1 ES 2458921B1 ES 201231533 A ES201231533 A ES 201231533A ES 201231533 A ES201231533 A ES 201231533A ES 2458921 B1 ES2458921 B1 ES 2458921B1
- Authority
- ES
- Spain
- Prior art keywords
- applications
- cognitive deficit
- obtaining procedure
- obtaining
- model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
Abstract
Modelo animal de déficit cognitivo, procedimiento de obtención y aplicaciones.#La invención se refiere a un modelo animal de déficit cognitivo el cual presenta ausencia de megalina específicamente en el endotelio de los capilares cerebrales, así como a su procedimiento de obtención y a su uso como modelo de enfermedades neurodegenerativas, más concretamente en Alzheimer.
Description
Claims (1)
-
imagen1
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201231533A ES2458921B1 (es) | 2012-10-05 | 2012-10-05 | Modelo animal de déficit cognitivo, procedimiento de obtención y aplicaciones |
PCT/ES2013/070693 WO2014053692A1 (es) | 2012-10-05 | 2013-10-07 | Modelo animal de deficit cognitivo, procedimiento de obtención y aplicaciones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201231533A ES2458921B1 (es) | 2012-10-05 | 2012-10-05 | Modelo animal de déficit cognitivo, procedimiento de obtención y aplicaciones |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2458921A1 ES2458921A1 (es) | 2014-05-07 |
ES2458921B1 true ES2458921B1 (es) | 2015-04-01 |
Family
ID=50434399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201231533A Expired - Fee Related ES2458921B1 (es) | 2012-10-05 | 2012-10-05 | Modelo animal de déficit cognitivo, procedimiento de obtención y aplicaciones |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2458921B1 (es) |
WO (1) | WO2014053692A1 (es) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090156525A1 (en) * | 2005-11-15 | 2009-06-18 | Zlokovic Berislav V | Low-Density Lipoprotein Receptor-Related Protein 2 Clears Amyloid-Beta Peptide A cross the Blood-Brain Barrier via Apolipoprotein J |
-
2012
- 2012-10-05 ES ES201231533A patent/ES2458921B1/es not_active Expired - Fee Related
-
2013
- 2013-10-07 WO PCT/ES2013/070693 patent/WO2014053692A1/es active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2458921A1 (es) | 2014-05-07 |
WO2014053692A1 (es) | 2014-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 2458921 Country of ref document: ES Kind code of ref document: B1 Effective date: 20150401 |
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FD2A | Announcement of lapse in spain |
Effective date: 20211004 |