ES245808A1 - A procedure for the obtaining of a new complex salt of estreptomycin (Machine-translation by Google Translate, not legally binding)
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A procedure for the obtaining of a new complex salt of estreptomycin (Machine-translation by Google Translate, not legally binding)
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
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Abstract
A process for obtaining a new complex salt of streptomycin, characterized in that the cold solution of streptomycin is added a small amount of 30 g or its alkaline salts with a very small amount of alpha-thioglycolic acid or its salts alkaline, achieved which, ie the stable solution of the antibiotic, is transformed into pantothenate dissolved streptomycin sulfate, adding first the sufficient amount of pantothenic acid and successively a hot alcoholic solution of benzidine, then proceeding to the separation of the precipitate of benzidine sulfate, by suitable means, and reacting the streptomycin pantothenate obtained with the Isionazide, which is verified in a few minutes, proceeding to cool at room temperature the solution containing the streptomynaliden-isonicotinyl-hydrazide pantothenate, and make it react with a concentrated solution and fr Calcium Heptagluconate, whereby, finally, the new complex salt of streptomycin is obtained, which once to the resulting solution, has been evaporated the alcohol present therein, under reduced pressure, corresponding capacity, and sterilization, can to be employed directly for injectable use, alone or associated with streptomycin sulfate or dihydrostreptomycin, as appropriate, or on the contrary, the complex salt can be obtained to the solid state by any convenient process, such as that of lyophilization. (Machine-translation by Google Translate, not legally binding)
ES0245808A1958-12-051958-12-05A procedure for the obtaining of a new complex salt of estreptomycin (Machine-translation by Google Translate, not legally binding)
ExpiredES245808A1
(en)
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