ES2364110B1 - PROCEDURE TO ELIMINATE TYRAMINE FROM DIFFERENT SOURCES. - Google Patents
PROCEDURE TO ELIMINATE TYRAMINE FROM DIFFERENT SOURCES. Download PDFInfo
- Publication number
- ES2364110B1 ES2364110B1 ES200803451A ES200803451A ES2364110B1 ES 2364110 B1 ES2364110 B1 ES 2364110B1 ES 200803451 A ES200803451 A ES 200803451A ES 200803451 A ES200803451 A ES 200803451A ES 2364110 B1 ES2364110 B1 ES 2364110B1
- Authority
- ES
- Spain
- Prior art keywords
- tyramine
- procedure
- dopamine
- enzymes
- eliminate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- DZGWFCGJZKJUFP-UHFFFAOYSA-N tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 229960003732 tyramine Drugs 0.000 title abstract 5
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 6
- DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 229960003638 dopamine Drugs 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- IPRPPFIAVHPVJH-UHFFFAOYSA-N (4-hydroxyphenyl)acetaldehyde Chemical compound OC1=CC=C(CC=O)C=C1 IPRPPFIAVHPVJH-UHFFFAOYSA-N 0.000 abstract 2
- CFFZDZCDUFSOFZ-UHFFFAOYSA-N 3,4-Dihydroxy-phenylacetic acid Chemical compound OC(=O)CC1=CC=C(O)C(O)=C1 CFFZDZCDUFSOFZ-UHFFFAOYSA-N 0.000 abstract 2
- IADQVXRMSNIUEL-UHFFFAOYSA-N 3,4-dihydroxyphenylacetaldehyde Chemical compound OC1=CC=C(CC=O)C=C1O IADQVXRMSNIUEL-UHFFFAOYSA-N 0.000 abstract 2
- XQXPVVBIMDBYFF-UHFFFAOYSA-N 4-hydroxyphenylacetic acid Chemical compound OC(=O)CC1=CC=C(O)C=C1 XQXPVVBIMDBYFF-UHFFFAOYSA-N 0.000 abstract 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 241000589776 Pseudomonas putida Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 108091008053 gene clusters Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229940107700 pyruvic acid Drugs 0.000 abstract 1
- 239000001384 succinic acid Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/25—Removal of unwanted matter, e.g. deodorisation or detoxification using enzymes
-
- A23L1/0153—
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Procedimiento para eliminar tiramina de diferentes fuentes. El procedimiento se basa en las reacciones catalizadas por los genes presentes en las agrupaciones génicas tyn y hpa de Pseudomonas putida U, partiendo de transformar tiramina y dopamina en 4-hidroxifenilacetaldehído y 3,4-dihidroxifenilacetaldehído, reacción que puede continuarse a los ácidos 4-hidroxifenilacético y 3,4-dihidroxifenilacético respectivamente, mediante las enzimas del cluster tyn y que, si se complementa con las enzimas del cluster hpa, permite la degradación y tiramina y dopamina en ácido pirúvico y ácido succínico. La invención se refiere además a las enzimas que catalizan el proceso, moléculas de ácido nucleico que las codifican, vectores que permitan su expresión y, especialmente a microorganismos recombinantes transformados con dichos vectores. Además, la invención se refiere al uso de microorganismos que posean los genes adecuados para expresar las proteínas implicadas en el proceso para reducir la tiramina y dopamina de alimentos.Procedure to eliminate tyramine from different sources. The procedure is based on the reactions catalyzed by the genes present in the tyn and hpa gene clusters of Pseudomonas putida U, starting from transforming tyramine and dopamine into 4-hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde, reaction that can be continued to acids 4- hydroxyphenylacetic and 3,4-dihydroxyphenylacetic acid respectively, through the enzymes of the tyn cluster and which, if complemented with the enzymes of the hpa cluster, allows degradation and tyramine and dopamine in pyruvic acid and succinic acid. The invention further relates to the enzymes that catalyze the process, nucleic acid molecules that encode them, vectors that allow their expression and, especially to recombinant microorganisms transformed with said vectors. In addition, the invention relates to the use of microorganisms that possess the appropriate genes to express the proteins involved in the process to reduce the tyramine and food dopamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200803451A ES2364110B1 (en) | 2008-12-04 | 2008-12-04 | PROCEDURE TO ELIMINATE TYRAMINE FROM DIFFERENT SOURCES. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200803451A ES2364110B1 (en) | 2008-12-04 | 2008-12-04 | PROCEDURE TO ELIMINATE TYRAMINE FROM DIFFERENT SOURCES. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2364110A1 ES2364110A1 (en) | 2011-08-25 |
| ES2364110B1 true ES2364110B1 (en) | 2012-06-27 |
Family
ID=44359156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200803451A Expired - Fee Related ES2364110B1 (en) | 2008-12-04 | 2008-12-04 | PROCEDURE TO ELIMINATE TYRAMINE FROM DIFFERENT SOURCES. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2364110B1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH641644A5 (en) * | 1978-09-04 | 1984-03-15 | Underberg Emil | METHOD FOR PRODUCING HISTAMINE ARMS, OR HISTAMINE-FREE FOODSTUFFS, FOODSTUFFS AND FEEDSTUFFS AND PRODUCTS MADE THEREFOR. |
| GB8319540D0 (en) * | 1983-07-20 | 1983-08-24 | Bovril Ltd | Amine removal |
-
2008
- 2008-12-04 ES ES200803451A patent/ES2364110B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2364110A1 (en) | 2011-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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| FD2A | Announcement of lapse in spain |
Effective date: 20240327 |