ES2358408B1 - TRANSFER COUPLING OF HIGH ACTIVITY PRODUCTS AND TRANSFER PROCEDURE USING THIS COUPLING. - Google Patents

Abstract

Transfer coupling of high-activity products and transfer method using said coupling, wherein the coupling comprises an upper bushing (4) associated with a product dosing tube (1) having at least one area for arranging a upper clamping element (6) of a first and second containment bags (7, 8), and a lower bushing (5) associated with a product receiving tube (2) that has at least two areas for disposing respectively a lower holding element (9) of the first containment bag (7) and another lower holding element (10) of the second containment bag (8).

Description

solution consisting of having two valves, one co-

Transfer coupling of high-activity products and transfer procedure using said coupling. Technical sector

The present invention is related to the transfer of high activity products that in excessive doses may be harmful to health, specifically the present invention refers to a device and a method, of preferred application for the pharmaceutical industry, which allow the transfer of isolated form of high activity products that are in solid, liquid or gaseous state. State of the art

In the pharmaceutical, biotechnology, chemical or biomedical industry, we work with products of high activity, that is, products that, due to their nature or the consequences of their application, even in small doses, require a manipulation in their transfer that guarantees their containment . As a non-limiting example of a high activity product is penicillin, since the minimum contamination of an operator who is allergic to this type of product can cause anaphylaxis.

During the production of a product of this nature, it is already in a solid, liquid or gaseous state, and when transferring it from a dosing device to a receiving container, an isolated transfer must be guaranteed preventing particles from the product from being released. that can contaminate the local environment.

It is known to dispose the dosing equipment in sealed chambers under pressure, so that any product intended to escape is limited to the sealed chamber and any fi ltered equipment used; however, the product, mainly if it is a powder product, has the tendency to contaminate the room and adhere to the outer surface of the container in which the product is placed, which causes the handling of the container to be an operation delicate.

A conventional solution for the transfer of high-activity products is based on making a manual transfer inside an isolated chamber that has two inputs to which gloves are tightly attached so that the operator manipulates the product, presenting the camera also some shots for air recirculation. This solution requires the use of filters and the need to clean the inside of the chamber every time a product is changed, and it is not a valid solution when you want to transfer large quantities of product since handling is slow and tedious.

Another solution is to provide a flushed tube at the outlet of the product dosing equipment that is connected to a bag that functions as the product's final receiver. This solution does not allow a free transit of the product along the tube due to its puckered form, in addition when the transfer is finished and the tube is decoupled, the product particles that remain in the folds of the tube are released and can Contaminate the external environment, since there is no containment in the tube coupling area with the receiving bag.

To avoid that, in product transfer operations, particles of the product that are transnected to a tube that communicates with a product dosing device and another connected to another tube that communicates with a product receiving equipment. The valves are normally closed by means of a sealing cap, which on the one hand has an internal face that is in contact with the product inside the tube and on the other side has an external face that communicates with the outside.

At first, before the product transfer occurs, the valves are coupled to each other, overlapping the outer faces of both sealing caps, so that the product is never in contact with said external faces, then the caps rotate together an angle of 90º allowing the free transit of product from the tube of the dosing equipment to the tube of the receiving equipment. With this solution, only the internal faces are contaminated with the product, so that when the covers return to their sealing position and the valves are disengaged, there are no particles that contaminate the external environment.

However, this solution has the disadvantage of not being valid for products in a liquid state because it requires perfect maintenance of the valve coupling system, since any wear and tear due to its use or manipulation can lead to grooves through which the product is introduced during the transfer phase, so that when the valves are uncoupled, the surfaces of the external faces thereof have product remains, therefore the valves do not perform their function of preventing the presence of product outside the containment system.

On the other hand, the valves have a high weight that makes handling difficult, they are also expensive and they need their own anchoring system for each equipment, which forces the valves and the equipment of the same manufacturer to be arranged.

In US patents US 6,647,700 and US 5,740,545 another solution is shown to prevent particles of a product being transferred from contaminating the external environment, for this, once the product transfer has occurred, a plug is inserted into a disposable tube that communicates the dosing equipment with the product receiving equipment, so the cap is divided in half by a cut or similar technique, the dosing equipment being isolated from the receiving equipment by the two halves leftover cap. Object of the invention

In accordance with the present invention, a coupling is proposed for the transfer of products of high activity of those employed in the pharmaceutical, chemical, or biological industry, which allows the transfer of such products from a simple, efficient and safe way from a dispensing equipment to a reception team.

The transfer coupling of high activity products object of the invention is used in product preparation and dispensing machines that have a product dosing equipment, which is associated with a product dosing tube, and a receiving equipment. of product that is associated with a product receiving tube.

The transfer coupling is composed of an upper bushing that is attached to the product dosing tube, said upper bushing having at least one area for arranging an upper holding element of a first and a second containment bag, and is composed also by a lower bushing that is connected to the product receiving tube, said lower bushing having at least two areas for respectively having a lower holding element of the first containment bag and another lower holding element of the second storage bag. containment.

The upper and lower bushings of the product transfer coupling have an annular gasket, preferably of silicone, which is arranged in the coupling area with its respective product dosing and receiving tube, this annular gasket performs the function of sealing between the bushes. and the tubes, as well as a damping function.

According to an embodiment of the invention, the fasteners of the containment bags are accessory elastic bands. According to another embodiment of the invention, the fasteners are elastic bands that are embedded in the containment bags themselves.

With all of this, the procedure for carrying out the transfer of high activity products from the product dosing equipment to the product receiving equipment comprises the following phases:

Phase a) Arrange a first product containment bag around a coupling area established between the upper bushing that is coupled to the product dispensing tube and the lower bushing that is coupled to the product receiving tube.

Phase b) Carry out the transfer of products from the product dispensing equipment to the product receiving equipment.

Phase c) Close the first containment bag approximately in half and divide it into two halves, an upper half that insulates the upper bushing and a lower half that insulates the lower bushing.

Phase d) Remove the assembly formed by the product dosing tube, the upper bushing and the upper half of the first containment bag, and arrange another dispensing tube of a new product with its respective upper bushing.

Phase e) Arrange a second product containment bag around the coupling area established between the new upper bushing and the lower bushing.

Phase f) Withdraw to the side, inside the second containment bag, the remaining lower half of the first containment bag that insulated the lower bushing and carry out the transfer of the new product from the new product dispensing tube to the tube Product receipt.

Phase g) Close the second containment bag approximately in half and divide it into two halves, an upper half that insulates the upper bushing and a lower half that insulates the lower bushing.

Before proceeding to close the second containment bag and according to a preferred embodiment of the invention, the remaining lower half of the first containment bag is placed inside the upper half of the second containment bag. Thus, when a new product is to be dispensed, the remaining lower half of the first containment bag is removed together with the upper cap and its product dosing tube.

According to an example of embodiment of the invention, the closure and division of each containment bag is carried out by means of two closing elements, such as two flanges, which are moored approximately in the middle of the respective containment bag and subsequently carried out between said closure elements a cut that sections the respective containment bag into two halves, an upper half and a lower half.

According to another example of embodiment of the invention, the closing and division of the respective containment bag is carried out by means of a single closing element that is tied approximately by half of the respective containment bag and subsequently said closing element is sectioned by its half dividing at the same time the respective containment bag into two halves, an upper half and a lower half.

In order to prevent the remaining lower half of the first containment bag from being accidentally introduced through the product receiving tube, it is provided that the lower sleeve has a safety net that seals the entrance of the product receiving tube allowing only the Product step

A system is thus obtained which, due to its constructive and functional characteristics, is a preferred application for the function to which it is intended in relation to the isolated transfer of high activity products. Description of the fi gures

Figure 1 shows a schematic view of the transfer coupling of high activity products object of the invention, presenting an upper bushing and a lower bushing.

Figure 2 shows the arrangement of a first containment bag over the coupling bushings.

Figure 3 shows the joining of the upper and lower bushings to carry out the transfer of a first product.

Figure 4 shows the coupling of the invention after the transfer of the first product has occurred.

Figure 5 shows the closure of the first containment bag.

Figure 6 shows the division of the first containment bag into an upper half and a lower half, for the removal of the upper bushing.

Figure 7 shows the arrangement of a second containment bag to carry out the transfer of a second product onto the coupling bushes.

Figure 8 shows the withdrawal to the side of the lower half of the first containment bag.

Figure 9 shows the joining of the upper and lower bushes to carry out the transfer of the second product.

Figure 10 shows the closure of the second containment bag and the arrangement of the remaining lower half of the first containment bag in the upper half of this second containment bag. Detailed description of the invention

The transfer coupling of high activity products object of the invention, represented in Figure 1, is used in a machine for preparing and dispensing products which, due to their nature and composition, even in small doses, can be dangerous. This machine has a product dosing equipment (not shown) associated with a dosing tube (1), and a product receiving device (not shown) associated with a product receiving tube (2). To establish the union of the tubes (1, 2) with their respective dosing equipment and product receiving equipment, two interlocking devices (3) are used, which are conventional and known to one skilled in the art.

The coupling object of the invention is constituted by an upper bushing (4) that is coupled to the free end of the product dosing tube (1) and a lower bushing (5) that is coupled to the upper end of the receiving tube (2) of product. The upper bushing (4) has at least one area to fix an upper fastening element (6) that can be used to tie a first and second containment bag (7, 8), while the lower bushing (5) has at least two zones for fi xing two lower fastening elements (9, 10) that can be used to tie the first and second containment bags (7, 8) respectively.

In the exemplary embodiment shown in the attached figures, the fasteners (6, 9, 10) are elastic bands surrounding the respective bushing (4, 5). However, the tie-up of the bags (7, 8) to the bushings (4, 5) could also be established by other fastening means, such as a heat seal, a vacuum joint, by means of fixing clamps, or similar means . It is envisaged that the placement of the fasteners (6, 9, 10) will be performed in a manual manner, however they could be placed by automatic means, without altering the concept of the invention.

The possibility is also provided that the containment bags (7, 8) themselves incorporate the fasteners (6, 9, 10) in the realization of elastic bands included in said bags (7, 8), likewise, It is planned that the containment bags (7, 8) have a pre-established cut line, so that they can be divided into two halves, as will be explained in detail below.

The bushes (4, 5) have an annular gasket (11) made of silicone or other similar material, which acts as a damping element and contact between said bushes (4, 5) and their respective tubes (1, 2).

With this mounting arrangement, the procedure for carrying out the transfer of high activity products is sequentially represented in the attached figures 2 to 10.

Figure 2 shows how the coupling area between the product dosing tube (1) and the product receiving tube (2) is isolated. The coupling area is isolated by means of a first containment bag (7) that is attached, on the one hand, to the upper bushing (4) by means of the upper holding element (6), and on the other hand to the lower bushing (5) by at least the lower clamping element (9). The part of the containment bag (7) that is attached to the lower bushing (5), can also be held simultaneously by both lower holding elements (9, 10) of said lower bushing (5).

Once the first containment bag (7) is correctly placed, as shown in Figure 3, the product transfer from the dosing equipment to the receiving equipment is carried out, by coupling the bushing (4) upper with lower bushing (5). Said coupling does not need to be airtight, since the bag (7) retains any particles of product that could escape, so it is not necessary to provide complex sealing systems.

To carry out the coupling of the bushings (4, 5) there are several possibilities, such as the upper bushing (4) descending, the dosing tube (1) descending together with the bushing (4), which ascends the bushing ( 5) bottom, which ascends the tube

(2) of reception together with the lower bushing (5), or that simultaneous movements of ascent and descent are made according to any of the aforementioned circumstances.

As can be seen in Figure 4, once the product transfer from the dosing equipment to the receiving equipment has been carried out, the upper and lower caps (4, 5) are decoupled in any of the ways indicated above. .

In Figures 5 and 6 it is shown how to proceed with the closure of the containment bag (7) approximately by means of parting and splitting into two halves that isolate the upper bushing (4) from the lower bushing (5). This closing and separation procedure of the containment bag (7) can be carried out manually or by means of an automatic anchoring and cutting system.

A preferred embodiment for carrying out the closing and division of the containment bag (7), is based on having two closing elements (12), such as two flanges, which are tied approximately in the middle of the bag (7) and between which a cut is made that cuts the containment bag (7) into two halves, an upper half and a lower half. Thus, the upper bushing (4) is insulated by the upper half of the containment bag (7), which above is tied to said bushing

(4)

by means of the upper clamping element (6) and below it is closed by one of the elements

(12)

closing, while the lower bushing (5) is insulated by the lower half of the containment bag (7), which is tied to said bushing

(5)

lower by means of the lower clamping element (9) and above is closed by the other element

(12)

of closing.

Another solution for carrying out the closure and division of the containment bag (7), is based on having approximately one half of the bag (7) about a single closing element (12) with a sufficient width so that it can be sectioned in half. In this way, both the bag (7) and the closure element (12) are divided into two halves that isolate, respectively, the upper bushing (4) and the lower bushing (5). Another solution is based on applying a seal in the area of division of the bag (7), thereby improving the tightness of the division of the bag. This last solution could be applied alone or in combination with the use of the closure elements (12).

After the transfer of a product is completed and the upper and lower bushings (4 and 5) are isolated, the product dosing tube (1) with its respective containment bag half (7) is removed and a new tube (1) is placed ) with a new product to be dosed.

Thus, as shown in Figure 7, the new coupling area between the upper bushing (4) of the new dosing tube (1) and the lower bushing (5) is isolated by a second containment bag (8) which it is tied, on the one hand, to the upper bushing (4) by means of a new upper clamping element (6), and on the other hand to the lower bushing (5) by the lower clamping element (10) that is located below the other lower clamping element (9).

Then, as shown in Figures 8 and 9, the lower clamping element (9) and the lower half of the first containment bag (7) which isolated the receiving tube (2), this lower half of the remaining The first containment bag (7) and its lower holding element (9) are placed on the side of the bushings (4, 5), so that when the coupling of the same occurs, the transfer of product is not hindered. Withdrawal to the side of the remaining lower half of the first containment bag (7) and its lower holding element (9) can be carried out manually by an operator, but it is planned to provide automatic means for Carry out this function, such as for example clamps located at one end of the lower bushing (5).

Finally, the procedure is repeated again by closing the second containment bag (8) approximately after its half and dividing it into two halves, so that the upper half of said second containment bag (8) isolates the upper bushing (4) and the other lower half isolates the lower bushing (5). Before proceeding with the closure of the second bag (8), the remaining lower half of the first containment bag (7) and its lower holding element (9) are placed in the upper half of the second containment bag (8) , so that when the tube is removed

(one)

If the product is dosed with its respective upper half of the second containment bag (8), the remaining lower half of the first containment bag (7) and its lower holding element (9) are carried.

The possibility of the bushing is planned

(5)

In the lower part there is a net, preferably in the outermost area, which allows the product to flow smoothly, but which prevents an accidental fall of the remaining lower half of the first containment bag (7) and its lower holding element (9), towards inside the tube (2) for receiving the product.

Claims (10)

one.

High-activity product transfer coupling, which is used in a product preparation and dispensing machine that has a product dosing equipment associated with a product dosing tube (1), and an associated product receiving equipment to a product receiving tube (2), characterized in that it comprises an upper bushing (4) which has at least one area for arranging an upper fastening element (6) of a first and a second bag (7, 8) of containment, and a lower bushing (5) having at least two zones for respectively disposing a lower holding element (9) of the first containment bag (7) and another lower holding element (10) of the second containment bag (8).

2.

Transfer coupling of high activity products, according to the first claim, characterized in that the upper and lower bushings (4, 5) have a respective coupling ring (11) in relation to the dosing tubes (1,2) and product reception.

3.

Transfer coupling of high activity products, according to the first claim, characterized in that the fasteners (6, 9, 10) are elastic bands.

Four.

Transfer coupling of high activity products, according to the first claim, characterized in that the fasteners (6, 9, 10) are elastic bands that are included in the first and second containment bags (7, 8).

5.

Transfer coupling of high activity products, according to the first claim, characterized in that the lower bushing (5) has a safety net that seals the entrance of the product receiving tube (2) allowing only the passage of product.

6.

Procedure for transferring high activity products using the device of the first claim, characterized in that it comprises the following phases:

Phase a) Arrange a first product containment bag (7) around a coupling area established between an upper bushing (4) that is coupled to a product dispensing tube (1) and a lower bushing (5) coupled to a tube

(2)

of product receipt.

Phase b) Carry out the product transfer from the product dispensing tube (1) to the tube

(2)

of product receipt.

Phase c) Close the first containment bag (7) approximately in half and divide it into two halves, an upper half that insulates the upper bushing (4) and a lower half that insulates the lower bushing (5). Phase d) Remove the assembly formed by the tube (1) dispensing, the upper bushing (4) and the upper half of the first containment bag (7), and arranging another dispensing tube (1) of a new product with its respective upper bushing (4). Phase e) Arrange a second product containment bag (8) around the coupling area established between the new upper bushing (4) and the lower bushing (5). Phase f) Withdraw to the side, inside the second containment bag (8), the remaining lower half of the first containment bag (7) that insulated the lower bushing (5) and carry out the transfer of the new product from the new product dispensing tube (1) to the product receiving tube (2). Phase g) Close the second containment bag (8) approximately in half and divide it into two halves, an upper half that insulates the upper bushing (4) and a lower half that insulates the lower bushing (5).

7.

Procedure for transferring high-activity products, according to the sixth claim, characterized in that in Phase c) and in Phase g) the closure and division of each containment bag (7, 8) is carried out by two elements (12 ) of closure that are tied approximately by half of the respective containment bag (7, 8) and a cut is made between the two closing elements (12), sectioning the respective containment bag (7, 8) into two halves , an upper half and a lower half.

8.

Procedure for transferring high-activity products, according to the sixth claim, characterized in that in Phase c) and in Phase g) the closure and division of the respective containment bag (7, 8) is carried out by means of an element ( 12) of closure that is tied approximately by half of the respective bag (7, 8) to section said element

(12) closing in half, dividing the respective containment bag (7, 8) into two halves, an upper half and a lower half. 9. Method of transferring high-activity products, according to the sixth claim, characterized in that between Phase f) and Phase g) the remaining lower half of the first containment bag (7) is placed inside the upper half of the second containment bag (8). SPANISH OFFICE OF THE PATENTS AND BRAND Application no .: 201001649 SPAIN Date of submission of the application: 12-30-2010 Priority Date: REPORT ON THE STATE OF THE TECHNIQUE 51 Int. Cl.: B65G69 / 18 (2006.01) RELEVANT DOCUMENTS

Category

Documents cited Claims Affected

X

GB 2465180 A (HANLEY NEAL et al.) 12.05.2010, description; Figures 1-13. 1-4

Y

5-9

Y

GB 2291863 A (EXTRACT TECHNOLOGY LTD) 07.02.1996, description; Figures 1-24. 6-9

Y

WO 2010134102 A1 (ABC PHARMATECH S R L et al.) 25.11.2010, description; Figures 1-13. 5

TO

1-4.6-9

TO

US 2008 145198 A1 (MULTER STEVEN et al.) 06.19.2008, description; Figures 1-14. 6

Category of the documents cited X: of particular relevance Y: of particular relevance combined with other / s of the same category A: reflects the state of the art O: refers to unwritten disclosure P: published between the priority date and the date of priority submission of the application E: previous document, but published after the date of submission of the application

This report has been prepared • for all claims • for claims no:

Date of realization of the report 04.24.2011

Examiner J. Moreno Rodríguez Page 1/5

REPORT OF THE STATE OF THE TECHNIQUE Minimum documentation searched (classification system followed by classification symbols) B65G Electronic databases consulted during the search (name of the database and, if possible, terms of search used) INVENES, EPODOC  WRITTEN OPINION Date of Written Opinion: 04.24.2011 Statement

Novelty (Art. 6.1 LP 11/1986)

Claims Claims 1-9 IF NOT

Inventive activity (Art. 8.1 LP11 / 1986)

Claims Claims 1-9 IF NOT

The application is considered to comply with the industrial application requirement. This requirement was evaluated during the formal and technical examination phase of the application (Article 31.2 Law 11/1986).  Opinion Base.- This opinion has been made on the basis of the patent application as published.  WRITTEN OPINION 1. Documents considered.- The documents belonging to the state of the art taken into consideration for the realization of this opinion are listed below.

Document

Publication or Identification Number publication date

D01

GB 2465180 A (HANLEY NEAL et al.) 12.05.2010

D02

GB 2291863 A (EXTRACT TECHNOLOGY LTD) 07.02.1996

D03

WO 2010134102 A1 (ABC PHARMATECH S R L et al.) 11.25.2010

D04

US 2008 145198 A1 (MULTER STEVEN et al.) 06.19.2008

2. Statement motivated according to articles 29.6 and 29.7 of the Regulations for the execution of Law 11/1986, of March 20, on Patents on novelty and inventive activity; quotes and explanations in support of this statement The object of the invention set forth in independent claim 1 is a high-activity product transfer coupling, which is used in a product preparation and dispensing machine that has a product dosing equipment associated with a dosing tube of product, and a product receiving equipment associated with a product receiving tube, the coupling comprising an upper bushing having at least one area for arranging an upper holding element of a first and a second containment bag and a lower bushing which has at least two zones for respectively disposing a lower holding element of the first containment bag and another lower holding element of the second containing bag. Document D01 discloses a transfer coupling (10) of material that cannot be exposed to external exposure, which is used to transfer this material from a dispensing container (100) of the material through a dosing tube ( 104) towards a receiving vessel (200) associated with a receiving tube (204), the coupling comprising an upper bushing (106) integrated in the dosing tube (104) which has two zones (108a and 108b) for arranging a holding element (16) of a first and a second containment bag (10) and a lower bushing (206) having two zones (108a and 108b) to respectively dispose a lower fastener (18) of the first bag (10) and the second containment bag (10). The fasteners (16 and 18) are hoops that are placed on the ends of the containment bags (10) and are wrapped by them, and in addition clamps (20) are used in the junction of the containment bags (10) with the upper and lower bushings (106 and 206 respectively) (description and figures 1-13). The fact that the upper and lower bushings are coupled to the dosing and receiving tubes by means of annular joints or are integrated in the tubes themselves is a difference that does not imply a novel contribution to the state of the art nor does it present a novel technical effect, Therefore, it is considered devoid of inventive activity. In view of this document D01, claims 1-4 lack inventive activity. The difference between what is disclosed in document D01 and claim 5 is that in the coupling disclosed therein, the inclusion of the filling of the receiving tube is not considered. The technical problem associated with this difference is that the rest of the containment bag (10) could fall, when it is removed (as explained later in reference to claim 5), within said tube of reception. However, this difference, as well as the technical effect associated with it, are included in document D03. This document discloses an apparatus for the transfer of pharmaceutical products in powder form, which has a system consisting of two ends (30a and 30b), through which in the process of replacing the containment bag (4), Remains of the bag to be replaced (4b) are hooked to the new containment bag (4), so that such debris (4b) is prevented from falling into the receiving tube (5) of the disclosed transfer apparatus (description and figures 113). The fact that a network is not used for sealing, but this system based on anchoring through ends (30a and 30b), for the resolution of the same technical problem, does not imply inventive activity. It would be clear to a person skilled in the art the combination of documents D01 and D03, it being in the light of said combination that claim 5 is lacking inventive activity. The object of the invention set forth in independent claim 6 is a method of transferring high-activity products using the device claimed in the first claim comprising the phases of arranging a first product containment bag around an established coupling zone between the upper and lower bush, transfer the product, close the first containment bag in half and divide it into two halves, an upper one that insulates the upper sleeve and a lower half that insulates the lower sleeve, remove the assembly formed by the upper tube, the upper bushing and the upper half of the first containment bag and disposing of a new assembly such as that mentioned, arranging a second product containment bag around the coupling area between the new upper bushing and the lower bushing, remove halfway into the second containment bag half lower left over of the first containment bag, and carry out a new product transfer, closing the second containment bag in half, dividing it into two halves, an upper one that insulates the upper bushing and a lower half that insulates the lower bushing .  WRITTEN OPINION Document D01 discloses a material transfer procedure that cannot be subjected to exposure to the outside using the device disclosed in this same document, which consists of the phases of arranging a containment bag (10) around the upper bushes (106 ) and lower (206), carry out the transfer of the material from the dosing tube (104) to the receiving tube (204) of the material, close the first containment bag (10) by two points, generating three zones, one central (62) and two ends (60) in contact with the upper and lower bushings and insulating them, removing the central area (62), remove the assembly formed by the dosing tube (104), the upper bushing (106) and the upper of the two extreme halves (60) into which the first containment bag (10) was divided in the previous step, arrange a second containment bag (10) around the upper bushes (106) and bottom (206), remove the bottom of the two extreme halves (60) to one side within the second containment bag (10) into which the first containment bag (10) was divided in the previous step and carry out a new material transfer, then closing the second containment bag (10) by two points, generating three zones, a central (62) and two extremes (60) in contact with the upper and lower bushings and isolating them. The way in which the closing and division phase of the containment bags is carried out turns out to be only a design option with no associated novel technical effect, and lacking inventive activity. The difference between the procedure disclosed in document D01 and that set forth in claim 5 is that in the case of the procedure disclosed in D01, physical contact between the lower and upper bushing is not established, the product being discharged along of the containment bag. The technical problem associated with this difference is that on the one hand, when this contact does not occur, part of the transferred material can be retained in the containment bag, assuming the loss of the same and on the other it is forced to eliminate the central fragment of the containment bag, which in this case will be impregnated with transferred material, independently, increasing the risk of exposure to the outside of the transferred material. However, this difference as well as the associated technical effect are included in document D02, in which it discloses an apparatus by means of which the transfer of a product is carried out, not allowing its exposure to the outside during the transfer. Said product is collected within a deposit (90), the transfer of which is carried out by means of a system (10), by direct contact between the deposit (90) of the product and a reception system (cone 51), being protected this connection by an external bag (92) that covers the union of both elements (description and figures 1-24). For an expert in the field it would be obvious, in view of document D02 to establish direct contact between the upper bushing (106) and the lower bushing (206) to minimize the loss of product in the transfer made, as well as the risk of exposure outside the transferred matter. Therefore, and in view of this combination of documents D01 and D02, claims 6-9 lack inventive activity.