ES2354883T3 - COSMETIC PREPARATIONS IN BALL FORM FOR THE TOPICAL APPLICATION. - Google Patents

Abstract

Cosmetic and / or dermatological preparation based on an Ag / Ac emulsion in the form of stable and / or rigid balls or spheroids, semi-rigid at a temperature of 35 ° C with a volume of 0.1 to 20 ml containing basically lipids, emulsifiers, polymers natural and / or synthetic and / or mixtures thereof, characterized in that the preparation consists of a stable mixture in the form of a lipid / emulsifier, the water dispersed with a droplet size of less than 50 micrometers.

Description

The present invention includes a cosmetic or dermatological preparation for topical application based on an anhydrous emulsion in the form of stable and / or rigid balls, semi-rigid, spheroids or other bodies with a specific shape that basically contain waxes, emulsifiers, polymers and / or synthetic and / or natural mixtures. The preparation is melted when it is extended by rubbing the skin and / or hair and / or due to the shear forces, it is mixed totally or partially with the lipids of the cutaneous sebum and / or dissolved in 5 of them.

Tablets for peroral pharmaceutical application have been known since the late 19th century. They are therefore single dose rigid pharmaceutical forms that have been formed from dry powders, crystals or granules under high pressure and in the presence of auxiliary substances ( Rudolf Voigt. ”Pharmazautische Technologie”; Deutsche Apotheker Verlag, Stuttgart, 9, Edition (2000). P 163 ff.) 10

Suppositories for rectal or vaginal application have also been used for some time. These are stably preparations, which melt at body temperature or dissolve slowly in an aqueous medium (2000), p. 267 ff.). They can be manufactured by compression or casting. According to the manufacturing method, other requirements in the raw materials used are adjusted in addition to the conventional pharmaceutical requirements such as good tolerance and compatibility with the active ingredient, for example, 15 small differences between the melting point and the solidification temperature as well as between the pour point and the melting temperature of a transparent liquid and at least the kinetic stability of the first crystalline modification. Suppositories for topical application have not been described so far.

Pharmaceutical capsules, for example, hard or soft gelatin capsules, consisting of a cover of gelatin and glycerin as well as possible colorants, and a liquid, pasty or particulate filler are also known from the current art. The method for manufacturing these capsules known for many years is governed by the so-called Rotary-Die system (Seifen-Öle-Fette-Wasche, 113, Jg; Nr 3/1987, page 67 ff.) These gelatin capsules are Dissolve when ingested in the gastrointestinal tract and release its contents. Since it is possible to manufacture capsules of different sizes and shapes, their use is not only limited to peroral application forms ((Rudolf Voigt. "Pharmazautische Technologie"; Deutsche Apotheker Verlag, Stuttgart, 9, Edition (2000). P 543 ff .) An oral resorption can be achieved by means of sucking capsules, inside they are hollow and have a wall thickness three times greater than other capsules.The active ingredient is incorporated in this case in the gelatin cover. Nitroglycerin chew capsules (capsules that break with the teeth) that also facilitate a rapid resorption of the active principle by the oral mucosa.In addition, the single-dose medications can be ingested after puncturing or cutting the capsules in the form of a tube by crushing out the content for application (percutaneous application of nitroglycerin balm).

From the food sector, for example, various solid preparations are known at room temperature, which melt at body temperature. These are mostly preparations based on vegetable fat, in particular based on cocoa butter as well as Shea butter (Chocolate) or water / oil emulsions based on hardened vegetable fats and free fatty acids ( margarine). Preparations called "ice cream" are also known, in which a high enthalpy of fusion must be applied and have a cold effect on the mouth.

In the cosmetics sector, the so-called pearls for the bath are discussed, whose cover, for example, 40 gelatin dissolves without leaving residues in a hot or cold water bath and its contents, for example, surfactant preparations, emulsions, lipids , dyes and / or perfumes, is released in the water bath. Since the cover consists of gelatin, the product should not contain water because otherwise the cover would soften during storage.

A second group of cosmetic capsules encompasses all products for which the cover 45 of the capsule is only equivalent to a container for a single dose and its application and whose cover after use is left over. The drawback is that the excess cover hinders and must be removed.

Numerous cosmetic and / or dermatological active substances are not stable against certain influences such as humidity, low or high pH or light. Therefore, there is no lack of trials to try to eliminate the aforementioned undesirable environmental influences in this type of substances, but nevertheless there is always an active substance release. One way to avoid it will be the micro- or macroencapsulation of the active substances. The encapsulated material as a support system for the active substance allows it to be incorporated into the appropriate preparations protected from environmental effects, without the user having to take over or take advantage of the capsules in the application of the product. 55

An objective of said encapsulation is, for example, to manufacture wax particles containing active substance of a magnitude of micrometers (1-250 µm), which can be incorporated into pasty or liquid cosmetic preparations. At the moment it is not known how to manufacture these microcapsules as an independent or autonomous cosmetic preparation, nor how to store and use them topically.

For the encapsulation of cosmetic active substances there are several approaches or approaches. 5 For example, it is known that liposomal encapsulation of pharmaceutical products can lead to a delayed release of the active substance. Basically it is a spherical vesicle that contains active substance surrounded by phospholipids or other amphiphiles, the so-called liposomes. However, the long-term stability of this type of configuration is low.

The nanoparticles are solid particles with particle sizes between 20 and 500 nm. 10 Occasionally, larger particles with diameters of up to 1000 nm are also calculated for the nanoparticles. These types of particles are generally composed of polymers and have cavities or form a shell, so that inside they can retain host molecules, which are adsorbed or enclosed. These host molecules are released slowly when using the product that contains the nanoparticles. In a similar way, solid lipid nanoparticles behave, which contain active substances distributed in solid lipids in a matrix. The particle size is comparable to that of the nanoparticles.

Numerous methods are known for the encapsulation of the pharmaceutical or cosmetic active ingredients or substances for the control of the release of the active substances or of the stable incorporation into the preparations. twenty

European patent EP064911 or EP1064912 reports microcapsules containing active ingredients, with a diameter of 0.1 to 5 mm, so that a matrix composed of gel-forming, chitosan and active ingredient is manufactured, and this is instilled in solutions aqueous anionic polymers. This forms a membrane based on chitosan and anionic polymer, which surrounds or wraps the active ingredient solution. These microparticles are then used again as a component of the conventional cosmetic preparations. In general, chitosan encapsulation techniques are reported in the Journal of Microencapsulation 14, pages 689-711 (1997).

The mostly lipophilic active substances, encapsulated based on lipid particles, are known. Thus, patents EP 167825, DE 100 59 668, DE 199 45 203, EP 0934743, WO 94/20072, WO 00/10522 as well as WO 00/67728 describe lipid particles loaded with active substances. These 30 documents have not been able to solve the problem of preparing preparations or compounds spherically with or without cosmetic substances, which can be manufactured as an independent cosmetic preparation, which can be stored and applied topically.

At room temperature, the solid protective bars of the lips based on Ag / Ac emulsions have been described in DE 10148313. This technology described therein is the object of the present invention. The emulsions according to DE 10148313 that are rubbed or scattered on the skin are not liquid and only an abrasion of the emulsion remains in the applied area, especially on the lips. A liquefaction of the described preparations is not desired, since for the care of the lips the material that is applied if possible is kept in the place of application for a long time and should not fly away.

The purpose of the present invention is therefore to achieve a cosmetic preparation that is present as a stable ball so that it can be applied to the skin as a single piece. So you should not leave residues, capsule material etc ... that must be removed in a special way or that are visible on the skin. In particular, the purpose of the present invention is to achieve a cosmetic preparation that corresponds to a new form of cosmetic product and offers the user a new field or application experience and broadens the application spectrum of skin care products and / or hair Four. Five

All this is achieved by a cosmetic preparation that meets the main claims. The preferred claims of the preparation are reported in the subclaims. The invention also includes the method for the application of the preparation on the skin and / or on the hair, the use and the combination with an alveolar or blister pack and boxes.

The expert has been particularly surprised that the proposed tasks have been solved by means of a cosmetic and / or dermatological preparation based on an Ag / Ac emulsion in the form of balls or spheroid stable and / or rigid, semi-rigid at a temperature 35º, with a volume of 0.1 to 20 ml, which basically contain waxes, lipids, emulsifiers, natural and / or synthetic polymers and / or mixtures thereof, so that the preparation consists of a mixture of lipid / emulsifier stable in shape, containing dispersed water with a droplet size of less than 50 micrometers. Below storage conditions, that is, at a temperature below room temperature, the preparations are totally or partially solid.

The advantage and at the same time the characteristic according to the invention of the capsule preparation is that

- when scrubbing and / or distributing the capsule through the skin and / or hair it melts and / or

- due to the shear forces, it is totally or partially liquefied and / or

- it dissolves in the filler and / or the skin sebum lipids or by mixing with the filler and the cover material

and in this way it is not perceptible by the user, as something special other than the filling of the preparation itself.

That is, preferably in the application on the skin or hair the capsule is completely detached if leaving residues.

Compared to the known cosmetic capsules, whose cover is after application, the ball described here is totally different. Therefore, the entire ball constitutes an active contribution or contribution for the care of the skin and / or hair in the cosmetic and dermatological preparation. Many terms such as "balls" or "capsules" can be used to describe the preparation according to the invention, but these terms according to the circumstances have different meanings. Thus the terms "Chocolate" or "suppository" are really not very cosmetic. fifteen

Let's join the types of application. The term "ball" or "capsule" to describe the preparation according to the invention is not limited to its mathematical meaning, but encompasses any exact or approximately regular or irregular body, ball-shaped, spherical, round, oval, ellipsoid, as well as those with corners and edges, such as parallelepipeds, squares, stars, hearts, cubes and the like.

The preparation according to the invention encompasses cosmetic products previously distributed in 20 doses, stable in form, at room temperature (RT), which when rubbed and / or distributed through the skin and / or hair, melt or liquefy or else dissolves This ensures that the cosmetic can be applied to the skin or hair without leaving annoying residue.

In the face of the capsule preparations currently known, there is no material residue left unused on the skin, which may be visible and that leads to unnecessary expenses and environmental charges since its elimination by the user is necessary after the application of the product . Preparations known today that have no capsule form such as chocolate or suppositories are not suitable for topical application, since they first have a poor melting temperature (the skin temperature is essentially below normal body temperature) and secondly they cannot be applied by rubbing. Thirdly, it is not about emulsions (with the exception of 30 margarine) and when the water is lacking they produce an unpleasant sensation on the skin, nothing cosmetic. For example, in the case of margarine, a lack of form stability during storage prevents an application within the meaning of the present invention.

The balls according to the invention have a size, that is, an average diameter, between 3 and 40 mm. The preparations according to the invention can have any type of shape. However, they are spherical with a volume between 0.1 and 20 ml. Therefore the balls can be applied and handled by themselves. The preparations are stable in form such as dragees, balls, spheroids, ellipsoids or other bodies, during storage and removal of the wrapper and when rubbing and scrubbing the skin and / or hair are liquefied. This is achieved, for example, by the special composition of the lipid phase of the Ag / Ac emulsion.

The ball-shaped preparation according to the invention must be rigid and stable in shape in the storage conditions to which its cosmetic products are normally exposed, that is, the shape of the balls according to the invention cannot be altered during storage or by the action of gravitation or temperature up to 35 ° C. Ideally, the balls do not stick during storage, even when two balls touch each other for a long time. Where appropriate, it is preferable to line each of the balls of a cover that improves the stability of the shape, prevents or decreases the bonding of each of the balls and / or reduces or prevents weight loss by evaporation of water and / or other easily volatile components.

The ball material of the compound according to the invention is completely on the skin without leaving insignificant residues. The preparation according to the invention therefore has the preferred properties of the known cream, cosmetic lotion etc. It is of great importance that all raw materials, from 50 of which the ball is constructed, are really well tolerated by the skin. Ideally they contribute to skin care so that they reinforce the skin's natural barriers and protect it from dryness.

The composition of the ball also has a significant influence on the user's skin sensation at

apply the product according to the invention. Therefore it is preferable that the ball is composed of those substances that provide a pleasant sensation.

The technical and sensory requirements described herein on the preparation according to the invention clearly exceed the conventional spectrum of use of known cosmetic preparations. It is therefore surprising that the preparation according to the invention can be manufactured with raw materials such as those already known to the technicians and are already used in cosmetics.

The following principles are taken into account. 5

On the one hand, lipids, whose melting point approaches the skin temperature of 32 ° C, that is between 30 ° C and 40 ° C, can be used for the manufacture of a preparation according to the invention. On the other hand, a thixotropic preparation can be manufactured using the waxes, the polymeric thickener and / or suitable gel-forming agents from fluid lipid systems with a high fluidity limit, which satisfies the requirements of the described preparation. It is clear to the expert that the aforementioned preparations, the use of 10 lipids with preferred melting points and the use of thixotropic systems with an adequate fluidity limit, can be combined in any way to optimize the properties of the preparation.

The preparation consists of a stable mixture in the form of a lipid / emulsifier, which contains the dispersed water with a particle size of less than 50 micrometers.

With the help of these advantages, the expert may be able to manage them to make a preparation according to the invention. The preparation is therefore characterized by the fact that

- when rubbing and / or spreading it through the skin and / or the hair melts and / or

- thanks to the shear forces it is partially or totally liquid and / or

- It is mixed with the lipids of the skin sebum and / or dissolved in them.

According to the invention, the cosmetic is applied to the skin and / or hair without leaving any residue. Without residues 20 it is equivalent to that visually no residues can be perceived on the skin or in the hair.

 Several balls according to the invention can be stored together in a paper-based container, metal or plastic, etc ... by means of thin containers similar to the paper of the chocolate or stored separately in a blister pack.

 In particular, the combination of the preparations according to the invention with a blister pack 25 is preferred, which during storage separates each of the balls and prevents them from joining together. This can be achieved by wrapping each of the balls with a thin sheet of paper, metal or plastic. In addition, the preparations can be packaged in tubes, for example, of polystyrene, or in sheets. You can use sheets of cellophane, aluminum and paper as well as plastic. In general, PE (polymerization degree of 3000-4000) serves as a material for this type of packaging. Other possibilities are the 30 pressure containers, in which a plastic sheet is used, for example, a sealed aluminum sheet. The preparations can, for example, be placed in folded boxes, cardboard boxes or plastic casts.

 The extraction of each of the balls according to the invention can be carried out in a simple way by hand. The balls have a manageable size according to the invention. But it is also possible to easily extract the preparation by means of a suitable dispensing system. For example, by activating a simple mechanism, the dispensing system can release each of the balls. Examples are the dispensing systems for chocolates and other sweet items of the company PEZ International AG under the brand "PEZ".

 But dispensing systems are also preferred in which the 40 balls of a helical round disk are stored in cavities and extracted individually by means of a metering mechanism. Especially preferred are those models that by their external form recall known cosmetic products, for example, the well-known NIVEA canister, since this reduces the danger of a mistake with food.

 In use, each of the balls is removed and the skin is rubbed with them. The product is not very viscous and is well distributed and dissolves through the skin or hair, when melting, cracking or dissolving the solid components of the product. It is clear to the expert that the preparation according to the invention may contain solid components, which will dissolve during application, that is, solid substances such as those used in conventional cosmetics, regardless of how they are found. Examples of this are fillers, dyes and photoprotective pigments. fifty

 The user removes one or several balls and rubs the skin with them as he would with a skin cream from a tube. However, it is preferable that he can use a previously parceled amount without waste and packaging.

 The advantage of the preparation according to the invention is the simple, comfortable individual application. In the same way that the lips are made up or greased it is possible to apply a cream or take care of the skin. In addition the 5 user can offer some balls to other users. This is certainly also possible in conventional cosmetic products, but the common use, for example, of a cream from the same jar, physiologically resembles body contact. Therefore there is a threshold or barrier of inhibition, which is eliminated by the present invention.

 It is also possible to offer in a package the balls according to the invention with different properties 10 (for example, perfume, color, skin sensation, photoprotective factor, active ingredients and combinations of these properties, which is not possible with care products of conventional skin.

 Another advantage is that the use of the balls according to the invention is more fun for some users like children than the use of the conventional cosmetic product. This can make it easier for parents to protect their children from dangerous environmental influences such as UV radiation. The expert knows that it is a big problem to protect cosmetic products against fungi, bacteria, germs that pass to the product during use. This occurs especially when the product is seized during the extraction process. It is clear that the balls according to the invention have another advantage here, since the user only touches those balls that he will use immediately. The rest of the balls are kept protected from microbial attack thanks to the fact that compared to conventional cosmetic products 20, for which reason they can be handled with lower contents in the preservation media, compared to conventional cosmetic products. Since the preservation media are part of the less tolerated cosmetic raw materials, greater product tolerance is achieved, which is another advantage of the present invention.

 The ball-shaped preparation may be composed of waxes, greases, oils, silicone oils, water, glycerin and other polyols, as well as other water or oil soluble additives. The ball has satisfactory shock stability, capable of withstanding mechanical loads during manufacturing and storage, and is thin enough to be able to be quickly distributed through the skin in the application.

 The lipid phase of the balls is preferably formed by waxes such as ceresin, ozokerite, waxes based on esters, waxes based on glycerides and / or fatty alcohols as well as solid emulsifiers and their mixtures. The waxes can be, by their origin, natural waxes, modified natural waxes, partially or totally synthetic waxes.

 All components are chosen to guarantee the required stability in terms of shape and temperature, prevent evaporation drying and quickly melt in the application, due to their partial or total liquefaction by shear forces or their dissolution in the Filling material. 35

 To optimize the elastic properties polymers can be incorporated into the preparation. Suitable polymers are cellulose ether, polyvinylpyrrolidone and its derivatives, polyacrylates or polymethacrylates, as well as Eudragit.

 The balls according to the invention are preferably composed of waxes from the group of

- natural waxes, in particular Carnauba wax, Candelila wax, lacquer wax, 40 berry wax (Rhus Verniciflura), Shea butter (Butyrospermum Parkii), hydrated vegetable oils, such as palm or rapeseed oil, wax of bees, whole wax (Eucerit)

- Mono-, Di- and triglycerides of highly saturated fatty acids with 10-30 carbon atoms or mixtures thereof, in particular glyceryl tripalmitate (Dynasan 116) and / or glyceryl stearate, glyceryl tribehenate (Syncrowax HRC ). Four. Five

- highly saturated fatty alcohols, in particular those with 14-30 carbon atoms, especially stearyl and / or behenyl and / or cetyl alcohol are preferred

- synthetic ester, preferably C16-36 alkylhydroxyetearoyl stearate, stearyl stearate, cetearyl behenate, C20-40 alkyl stearate, in particular, cetyl palmitate, methyl palmitate, myristyl myristate, cetyl ricinoleate 50

- polymeric waxes, preferably polyethylene, polypropylene, polyvinyl ether, polydecene, in particular polyvinyl stearyl ether and hydrated polydecene

- copolymers, preferably those of ethylene acetate and vinyl as well as

polyvinylpyrrolidone and hexadecene

- carbon hydrocarbons / paraffin waxes, in particular Microcrystalline Wax, Paraffin Wax, Ceresin, Ozokerite

- Silicone waxes

- Chemically modified waxes

- any mixture of waxes from the groups mentioned 5

Especially preferred waxes according to the invention for the preparation of the preparation according to the invention are cetyl palmitate, cetyl ricinoleate, beeswax, hydrated cocoglyceride, methyl palmitate, Candelilla wax, Carnauba wax, paraffin, ceresin, ozokerite, myristyl myristate, tripalmitin, tribehenin, glyceryl palmitosterate, hydrated rapeseed oil, and C15-40 alkyl stearyrate stearate. 10

 The balls according to the invention may contain the conventional additives and auxiliary substances that are well known to those skilled in the art and normally used in cosmetics. For example, preservatives, bactericides, substances with deodorant action, antiperspirants, insect repellents, vitamins, means to avoid foam, colorants, pigments with coloring action, taste substances, denaturing agents, perfumes, thickeners, softening substances, wetting substances and / or that contain moisture, antioxidants, UV filter substances, sensory additives, film formers, surfactants, emulsifiers, fats, oils, waxes, active ingredients or other common components of a cosmetic formula such as alcohols, polyols, stabilizing polymers , foam stabilizers, electrolytes, organic solvents or silicone derivatives.

Preferred Ag / Ac emulsifiers may be used: fatty alcohols with 8 to 30 carbon atoms, sanitized and / or unsaturated, branched or unbranched alkanocarboxylic acid monoglycerin esters of a chain length of 8 to 24, in particular from 12 to 20 carbon atoms, diglycerin ester of saturated and / or unsaturated alkanocarboxylic acids, branched or unbranched chain lengths from 8 to 24, in particular from 12 to 20 hydrocarbon atoms, monoglycerin ether of saturated alcohols and / or unsaturated, branched or unbranched of a chain length from 8 to 25 24, in particular from 12 to 20 carbon atoms, diglycerin ether of saturated and / or unsaturated, branched or unbranched alcohols of a chain length from 8 to 24, in particular from 12 to 20 carbon atoms, polypropylene glycol ester of saturated and / or unsaturated, branched or unbranched alkanocarboxylic acids of a chain length of 8 to 24, in particular 12 to 20 carbon atoms, polyglyceryl ester of saturated and / or unsaturated alkanocarboxylic acids, branched or unbranched 30 of a chain length of 8 to 24, in particular 12 up to 20 carbon atoms, sorbitan ester of saturated and / or unsaturated alkanocarboxylic acids, branched or unbranched with a chain length of 8 to 24, in particular 12 to 20 carbon atoms.

Preferred Ag / Ac emulsifiers are polyglyceryl 3 diiso stearate, polyglyceryl 4 isostearate, polyglyceryl dipolyhydroxystearate 2, cetyl dimethicone PEG / PPG-10-1, PEG-35 30 dipolyhydroxystearate, sorbitanimethyrateimethyl copolyol, copolyol cetyl ketone hydrochloride PEG-7 hydrogenated beaver, PEG 45 / dodecyl glycol copolymer, PEG 22 / dodecylglycol copolymer, pentaerythrityl iso stearate, isostearyldiglyceryl succinate, sorbitan isostearate, polyglyceryl sesquisoarate 2, sorbitan sorbrate hydratearate stearate, hydroxy stearate hydrochloride PEG-25, sorbitan peroxide PEG-40, sorbitan oleate, sorbitan perisoesterate PEG-40, polyglyceryl-3 oleate, polyglyceryl-2 sesquioleate and 40 polyglyceryl-4 isostearate.

Especially preferred Ag / Ac emulsifiers are the polyethylene glycol-45 / dodecylglycol copolymer, the polyglyceryl-3 diisoestearate, the PEG-30 dipolyhydroxystearate, sorbitan isoestearate, sorbitan stearate, glyceryl isostearate, glyceryl oleate stearate.

It is also possible to give up reducing the surface energy limit by emulsifiers or surfactants and instead stabilize the boundary surface by storing insoluble particles in both phases. Natural or artificial polymers (polyethylene, nylon, starch and its derivatives) or inorganic particles (TiO2, Al2O3, BaSO4, BN, silicates, alumina silicates, SiO2, aerosol) can be used for this.

The oleic phase, the lipids of the formulas according to the invention, which are preferably chosen from the group of polar oils, for example, from the group of lecithins and triglycerides of fatty acids, that is, from the triglycerin ester of saturated alkanocarboxylic acids and / or unsaturated, branched and / or unbranched are from the group of synthetic, semi-synthetic and natural oils, such as coconut glyceride, olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil , almond oil, oil

palm, coconut oil, castor oil, wheat germ oil, grape seed oil, thistle oil, macadamia nut oil, evening primrose oil and the like.

Other preferred polar oleic components of the present invention may be chosen from the group of saturated and / or unsaturated, branched and / or unbranched alkanocarboxylic acid esters of a chain length of 3 to 30 C atoms and from the group of saturated and / or unsaturated alcohols, 5 branched and / or unbranched chain lengths of 3 to 30 C atoms as well as the group of esters of aromatic carboxylic acids and saturated and / or unsaturated alcohols, branched and / or unbranched with a chain length of 3 to 30 C atoms. Said sterols may preferably be selected from the group of octyl palmitate, octyl cocoate, octyl isostearate, octyldodecyl myristate, octyldodecanol, cetearyl isononanoate, isopropyl myristate , isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, stearat or isononyl, isononyl nonanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, stearyl heptanoate, oleyl oleate, oleyl erucate, erucyl erucium belching, tridecyl stearate, tridecyl trimethylate, as well as synthetic, semi-synthetic and natural mixtures of such esters, such as jojoba oil. fifteen

In addition, the oleic phase can be chosen from the group of dialkyl ethers and carbonates, and dicaprilyl ether (Cetiol OE) and / or dicaprilyl carbonate are preferred, for example, which is known as Cetiol CC.

Also preferred are the oleic components of the isoeicosan group, neopentyl glycol diheptanoate, propylene glycol dicaprilate / dicaprate, caprylic / caprylic acid triglycerides, caprylic / capric diglyceryl succinate, butylene glycol dicaprate dicaprate, C12 lactate, 12 -13-alkyl, triisoestearin, dipentaerythrityl hexacaprilate / hexacaprate, propylene glycol monoisoestearate, tricapriline, dimethyl isosorbide. In particular, it is preferred that the oleic phase of the formulas according to the invention have a C12-15 alkyl benzoate content or its total content.

Preferred oleic components are also, for example, butyloctyl salicylate (for example, known as Hallbrite BHB), hexadecyl benzoate and butyloctyl benzoate and mixtures thereof (Hallstar AB) and / or naphthalate diethylhexyl Hallbrite TQ or Corapan TQ from H&R).

Any mixture of said oil and wax components can also be used within the meaning of the present invention.

In addition, the oleic phase may contain non-polar oils, for example, those selected from the group of branched and unbranched hydrocarbons and waxes, in particular mineral oil, petrolatum (Petrolatum), paraffin oil, squalane and squalene, polyolefins, hydrogenated polyisobutene and isohexadecane. Among the polyolefins, polyidecenes of the preferred substances are known.

Preferably the oleic phase can have a content in cyclic or linear silicone oils or consist entirely of said oils but in general an additional content of 35 other components of oleic phases in addition to the silicone oil or silicone oils is preferred.

Silicone oils are synthetic polymeric compounds of high molecular weight, in which silicon atoms are joined by oxygen atoms and the remaining valences of silicon are saturated by hydrocarbon radicals (mainly methyl, ethyl, propyl, phenyl, among others). Silicone oils are systematically known as polyorganosiloxanes. Polyorganosiloxanes with a substituted methyl group, which represent the majority of significant compounds in this group and are characterized by the following structural formula

image 1

 Four. Five

and are known as polydimethylsiloxane or dimethicone (INCI). Dimethicone exists in different chain lengths or with different molecular weights. fifty

 Especially preferred polyorganosiloxanes within the meaning of the present invention are, by

example, dimethylpolysiloxanes (poly (dimethylsiloxane)), which are known under the trade name of Abil 10 to 10,000 in Th. Goldschmidt. In addition, phenylmethyl polysiloxanes (INCI: Phenyldimethicone, Phenyltrimethicone), cyclic silicones (octamethylcyclotetrasiloxane or decamethylcyclopentasiloxane) which according to INCI are also known as cyclomethicone, aminomodified silicones (INCI: amodimethiclimea, copolymethyl ester, silicone example) are preferred. -polyalkylene (INCI: Stearyl dimethicone and 5-cetyl dimethicone) and dialkoxidimethyl polysiloxane (Stearoxidimethicone and behenoxy stearyl dimethicone) which are obtained in Th. Goldschmidt as different types of Abil wax. But it is also preferred to employ other silicone oils within the meaning of the present invention, for example cetyl dimethicone, hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

 It is also preferred to add conventional antioxidants to the preparations within the meaning of the present invention. According to the invention, all conventional antioxidants used in cosmetic and / or dermatological applications can be used as favorable antioxidants.

 Antioxidants from the group consisting of amino acids (for example, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazole (for example, urocaninic acid) and their derivatives, peptides such as D, L-Carnosine, D-Carnosine are preferred , L-Carnosine and its derivatives (for example, Anserine), Carotinoids, Carotins (for example, alpha-carotine, beta-carotine, lycopene) and their derivatives, retinoids such as, for example, Retinol, Retinal and / or retinic acid and the corresponding esters, alpha-liponic acid and its derivatives (for example, dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (for example, thioredoxin, glutathione, cysteine, cystine, cystamine and their N-acetyl, methyl, ethyl esters , propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl) as well as their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximin compounds (for example, butioninsulfoximin, homocysteinsulfoximin, butioninsulfone, penta-, hexa-, heptationinsulfoximin) in very low tolerable doses (for example, pmol to µmol / kg), in addition to metal chelates (for example, fatty α-hydroxy acids, palmitic acid, lactoferrin), α-hydroxy acids (for example, citric acid, lactic acid, malic acid), huminic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, IDS, EGTA and its derivatives, unsaturated fatty acids and their derivatives (eg, γ-linolenic, linoleic, oleic acid), folic acid and its derivatives, 2-aminopropionic acid, flavonoids, polyphenols, alpha-glucosylrutin, propyl gallate, catechin, ubiquinone and ubiquinol and its derivatives, vitamin C and derivatives (for example, ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (for example, ac vitamin E ethate), as well as 30 coniferyl benzoate of benzol resin, rutinic acid and its derivatives, ferulic acid and its derivatives, butylhydroxytoluol, butylhydroxyanisole, nordihydroguayaric acid resin, nordihydroguayaric acid, trihydroxybutyrophenone, uric acid and its derivatives mannose and its derivatives, zinc and its derivatives (for example, ZnO, ZnSO4), selenium and its derivatives (for example, selenium methionine), stilbene and its derivatives (for example, stilbene oxide, trans-stilbene oxide) and Suitable derivatives according to the invention (salts, esters, sugar, nucleotides, nucleosides, peptides and lipids) of these mentioned active substances.

 The amount of antioxidants (one or more compounds) in the preparations is preferably between 0.001 and 30% by weight, in particular between 0.05 and 20% by weight, in particular 0.1 and 10% in weight with respect to the total weight of the preparation. 40

 Whenever vitamin E and / or its derivatives are equivalent to the antioxidant (s), it is preferable that their respective concentrations are between 0.001 and 10% by weight, based on the total weight of the formula.

 In addition to the preparation according to the invention UV filter substances can be added. Therefore it is preferred to use the preparations according to the invention as photoprotective formulas.

The liquid UV filter substances at room temperature within the meaning of the present invention are preferred and these are homomethylsalicylate (INCI: homosalate), 2-ethylhexyl-2-cyano-3,3-diphenylacrylate (INCI: Octrocrylene), 2-ethylhexyl-2-hydroxybenzoate (2-methylhexylsalicylate, octylsalicylate, INCI: octyl salicylate) and cinnamic acid esters, preferably 4-methoxycinnamic acid (2-ethylhexyl-4-methoxycinnamate, INCI: octyl methoxycinnamate) and isopentyl ester of 4-methoxycinnamic acid (isopentyl-4-methoxy-cinnamate, INCI: isoamyl p-methoxycinnamate) - 50

Preferred inorganic pigments are metal oxides and / or water soluble or water insoluble metal compounds, in particular titanium oxides (TiO2), zinc (ZnO), iron (Fe2O3), zirconium (ZrO2), silicon (SiO2) , manganese (for example, MnO), aluminum (Al2O3), cerium (for example, Ce2O3), mixed oxides of the corresponding metals as well as mixtures of other oxides such as barium sulfate (BaSO4).

The pigments can be used in the sense of the present invention in the form of aqueous or oily dispersions commercially obtained. These prior dispersions will be added as dispersion and / or solubilization media.

The pigments can be treated superficially ("gecoatet", so that for example their hydrophilic, amphiphilic or hydrophobic character can be maintained. This surface treatment may consist of the pigment being coated with a thin, hydrophilic and / or inorganic organic layer. and / or hydrophobic The different surface coatings may also contain water within the meaning of the present invention.

Inorganic surface coatings within the meaning of the present invention may consist of 5 aluminum oxide (Al2O3), aluminum hydroxide Al (OH) 3 or hydrated aluminum oxide (also: aluminas, CAS-Nr.:1333-84- 2), sodium hexametaphosphate (NaPO3) 6, sodium metaphosphate (NaPO3) n, silicon dioxide (SiO2) (also silica, CAS-Nr.:7631-86-9), or ferric oxide (Fe2O3). These inorganic surface coatings may be presented alone, in combination, and / or in combination with organic coating materials. 10

Organic surface coatings within the meaning of the present invention may consist of vegetable or animal aluminum stearate, vegetable or animal stearinic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), methyl polysiloxane (methicone), simethicone (a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 units of dimethylsiloxane and silica gel) or alginic acid. These organic surface coatings may be presented alone, in combination and / or in combination with inorganic coating materials.

Suitable zinc oxide particles according to the invention and dispersions of zinc oxide particles are obtained in the following companies under the corresponding trade names:

 Tradename

 Coating

 Z-Cote HP1

 2% dimethicone

 Z-Cote

 /

 ZnO NDM

 5% dimethicone

 twenty

Suitable titanium dioxide particles and previous dispersions of titanium dioxide particles are obtained under the following trade names:

 Tradename

 Coating

 MT-100TV

 Aluminum hydroxide / stearinic acid

 MT-100Z

 Aluminum hydroxide / stearinic acid /

 Eusolex T-2000

 Alumina / simethicone

 Titanium dioxide T805 (Uvinul TiO2)

 Octyltrimethylsilane

The UV-A filter substances preferable in the sense of the present invention are those derived from dibenzoylmethane, in particular 4- (tert.-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), 25 which is marketed by Givaudan under the brand name Parsol® 1789 and under the trade name Eusolex®9020.

Also suitable UV-A filter substances are hydroxybenzophenones. These are characterized by the following structural formula:

image 1

 30

where

- R1 and R2 are equivalent to hydrogen, C1-C20-alkyl, C3-C10-cycloalkyl or C3-C10-cycloalkenyl, so that the substituents R1 and R2 together with the nitrogen atom, to which they are linked, can form a 5 or 6 ring and

- R3 is equivalent to a C1-C20-alkyl radical

An especially preferred hydroxybenzophenone within the meaning of the present invention is the hexyl ester 5 of 2- (4’-diethylamino-2’-hydroxybenzoyl) -benzoic acid (also: aminobenzophenone), which is characterized by the following structure:

image 1

 10

and you get in Fa. BASF under the name Uvinul A Plus. fifteen

 The total amount of one or more hydroxybenzophenones in cosmetic or dermatological preparations is preferably selected from the range of 0.01 to 20% by weight, preferably 0.1 to 10% by weight, based on the total weight of the preparations.

Other preferred UV filter substances within the meaning of the present invention are sulphonated water soluble UV filters, such as:

- Phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts, in particular the corresponding sodium, potassium or triethanolammonium salts, especially the phenylene-1 salt , 4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic-bis-sodium with the INCI designation Bisimidazilate CAS-No .: 180898-37-7), which is known for example under the name commercial Neo Heliopan AP;

- The salts of 2-phenylbenzimidazol-5-sulfonic acid, such as its sodium, potassium or triethanolammonium salt as well as the sulfonic acid itself with the INCI designation of Phenylbenzimidazole sulfonic acid (CAS-No. 27503-81-7), which is obtained for example under the trade name of Eusolex 232 in Merck or under the name of Neo Heliopan Hydro;

- 1,4-di (2-oxo-10-sulfo-3-bornylidenmethyl) -benzol (also: 3,3 '- (1,4-phenylenedimethylene) -bis- (7,7-dimethyl-2-oxo -bicyclo- (2.2.1) hept-1-ylmethanesulfó-nico) and its salts (in particular the corresponding 10-sulfate compounds, especially the corresponding sodium, potassium or triethanolammonium salt), which is also known as benzol acid -1,4-di (2-oxo-3-bornylidenmethyl-10-sulfonic acid) Benzol-1,4-di (2-oxo-3-bornylidenmethyl-10-sulphonic acid) has the INCI designation of Terephthalidendicanferolsulfonic acid ( CAS-Nº: 90457-82-2) and is obtained under the commercial name of Mexoryl SX; 35

- Derivatives of 3-benzylidene-camphor sulfonic acid, such as 4- (2-oxo-3-bornylidenmethyl) -benzolsulfonic acid, 2-methyl-5- (2-oxo-3-bornylidenemethyl) sulfonic acid and its salts.

Preferred UV filter substances within the meaning of the present invention are the so-called broadband filters, that is, the filter substances that absorb both UV-A and UV-B radiation.

Preferred broadband filters or UV-B filters are, for example, triazine derivatives, such as for example

- 2,4-bis- [4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: Aniso Triazine), which is obtained under the trade name of Tinosorb® S;

- Diethylhexylbutylamidotriazone (INCI: diethylhexylbutamidotriazone), which is obtained under the trade name UVASORB HEB; Four. Five

- 4,4 ', 4' '- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic-tris (2-ethylhexyl ester), also: 2,4,6-tris- ( anilino- (p-carbo-2'-ethyl-1'-hexyloxy)) - 1,3,5-triazine (INCI: octyltriazone), which is marketed by BASF

Aktiengesellschaft under the trade name UVINUL® T 150.

A preferred broadband filter within the meaning of the present invention is also 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl ) -phenol), which is obtained under the trade name of Tinosorb® M.

The preferred broadband filter within the meaning of the present invention is also 2- (2H-5 benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- (1,3,3,3 -tetramethyl-1 - ((trimethylsilyl) oxy) disiloxanyl) propyl] -phenol (CAS-Nr.:155633-54-8) under the INCI designation of drometrizol trisiloxane, which is obtained under the trade name Mexoryl® XL.

The following UV filter substances can be soluble in oil or water. Preferred oil soluble filter substances are, for example:

- Derivatives of 3-benzylidene camphor, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidenecamphor;

- Derivatives of 4-aminobenzoic acid, preferably 2- (ethylhexyl) ester of 4- (dimethylamino) benzoic acid, amyl ester of 4-dimethyl aminobenzoic acid;

- Benzophenone derivatives, preferably 2-hydroxy-4-methoxybenzophenone, 2-15 hydroxy-4-methoxy-4’-methylbenzophenone, 2,2’-dihydroxy-4-methoxybenzoenophenone

- UV filters attached to the polymer,

- the 3- (4- (2,2-bis-ethoxycarbonylvinyl) -phenoxy) propenyl) -methoxysiloxane / dimethylsiloxane copolymer, which is known under the trade name of Parsol® SLX.

It is also preferred to add to the preparations within the meaning of the present invention, the conventional antioxidants. According to the invention, all conventional antioxidants for cosmetic and / or dermatological applications can be used as favorable antioxidants.

The amount of antioxidants (one or more compounds) in the preparations preferably ranges from 0.001 to 30% by weight, in particular between 0.05 and 20% by weight, especially between 1 and 10% by weight with respect to the total weight of the prepared. 25

Provided that the cosmetic or dermatological preparation is equivalent to a solution or emulsion or dispersion within the meaning of the present invention, it can be used as solvents:

The preferred water soluble filter substances are, for example:

Sulfonic acid derivatives of 3-benzylidenecamphor, such as 4- (2-oxo-3-bornylidenmethyl) benzolsulfonic acid, 2-methyl-5- (2-oxo-3-bornylidenmethyl) sulfonic acid and its salts. 30

Another photoprotective filter substance which is preferably used in accordance with the invention is ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrilen), which is obtained under the name Uvinul® N 539.

Especially preferred preparations within the meaning of the present invention, which are characterized by high protection against UV-A and UV-B rays in addition to the filter substances according to the invention other broadband and / or UV-ray filters A, in particular, the dibenzoylmethane derivatives (for example, 4- (tert.-butyl) -4'-methoxydibenzoylmethane), phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5 , 5'-tetrasulfonic acid and / or its salts, 1,4-di (2-oxo-10-sulfo-3-bornidylenmethyl) -benzol and / or its salts and / or 2,4-bis - {[4 - (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine, respectively alone or in any combination.

The list of the mentioned UV filters that can be used in the sense of the present invention should not be limited. 40

The preparations according to the invention preferably contain the substances that absorb UV radiation in the UV-A and / or UV-B field, in a total amount of, for example, 0.1% by weight to 30% by weight, preferably from 0.5 to 20% by weight, in particular from 1.0 to 15.0% by weight, with respect to the total weight of the preparations, to have cosmetic preparations that protect the skin from the entire field of ultraviolet radiation . They can also serve as a protective means of hair. Four. Five

Preparations presented as emulsions especially contain one or more hydrocolloids. These hydrocolloids can preferably be chosen from the group of gums, polysaccharides, cellulose derivatives, silica and aerosols, layer silicates, polyacrylates and / or other polymers.

Among the gums is the sap, which hardens with air and forms resins or extracts from aquatic plants. From this group within the meaning of the present invention, for example, gum arabic, locust bean flour or tragacanth, karaya, guar gum, pectin, Gelan gum, carrageenan, agar, algina, chondrus, xanthan gum can be chosen.

The use of derivatized gums, such as hydroxypropyl guar (Jaguar® HP 8), is preferable. 5

 Among the polysaccharides and derivatives are, for example, hyaluronic acid, chitin and chitosan, chondroitin sulfate, starch and starch derivatives.

Cellulose derivatives include, for example, methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose.

Among the layer silicates are synthetic and naturally occurring clays such as, for example, Montmorillonite, Bentonite, Hectorite, Laponite, magnesium aluminum silicate such as Veegum®. These can be used as such or in a modified form such as, for example, stearalkonium hectorite.

The silicic acid gels can also be used, for which manufacture, for example, pyrogenic silicic acid (for example, Aerosil 200, 300, 800, R 812 or R 972 types) can be used.

In addition, Taurates are preferred, for example, the ammonium acryloxy dimethyl taurate / VP 15 copolymer

 Among the polyacrylates are, for example, the Carbopol types (Carbopol 980, 981, 1382, 5984, 2984, EDT 2001, ETD 2020, ETD 2050, Ultrez-10 or Pemulen TR1 & TR2).

 Among the polymers are polyacrylamides (Seppigel 305), polyvinyl alcohols, PVP, PVP / VA copolymer, polyglycols.

 The aqueous phase of the preparations according to the present invention may contain preferred conventional cosmetic auxiliary substances such as, for example, alcohols, in particular those of low carbon numbers, preferably ethanol and / or isopropanol, diols or number polyols low carbons and their ethers, preferably propylene glycol, glycerin, butylene glycol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether, ethylhexyglycerol polymers, stabilizer, polyether polymers electrolytes such as, for example, sodium chloride or magnesium sulfate as well as in particular one or more thickeners, which may preferably be selected from the group of silicon dioxide, aluminum silicate, polysaccharides or their derivatives, for example, hyaluronic acid, gum xanthan, hydroxypropylmethyl cellulose, in particular those of the polyacrylate group, preferably a polyacrylate of the so-called carbopoly group, for example carbophores of types 980, 981, 984, 1342, 1382, 2984 and 30 5984, also types ETD 2001, 2020, 2050 and Carbopol Ultrez 10, alone or in combination.

 The preparations according to the invention may preferably contain self-tanning substances, such as dihydroxyacetone and / or melanin derivatives in concentrations of 0.1 to 10% by weight with respect to the total weight of the preparation.

 Furthermore, the preparations may preferably contain, according to the invention, repellents to protect against flies, ticks and spiders and the like. Preferred are, for example, N, N-diethyl-3-methylbenzamide (trade name: Metadelphen, "DEET"), dimethyl phthalate (trade name: Palatinol M, DMP) as well as the 3- (ethyl ester of acid ( -n-butyl-N-acetyl-amino) -propionic (under the trade name of Insekt Repellent® 3535). Repellents can be used alone or in combination. Aromatic oils or the like can also be used. 40

 As moisturizing media and / or substances that moisturize the skin are known substances or mixtures of substances that give cosmetic or dermatological preparations the property of reducing moisture release from the corneal layer (also called transepidermal water loss (TEWL) and / or positively influence the hydration of the cornea layer, after application or distribution on the surface of the skin.The preferred humectants within the meaning of the present invention are, for example, glycerin, lactic acid and / or lactates, in particular, sodium lactate, butylene glycol, propylene glycol, panthenol, fucogel, glycine soy, ethylhexylglycerin, pyrrolidoncarboxylic acid and its derivatives, as well as urea, and polymeric humectants of the water-soluble and / or water-swellable polysaccharides group are also preferred. and / or gellable with the aid of water, in particular, for example, hyaluronic acid, chitosan and / or a polysaccharide ri co in fucose, which is found in the Chemical Abstracts under registration number 178463-23-50 5 and, for example, are obtained under the name Fucogel® 1000. The humectants can preferably be used as anti-wrinkle active ingredients for prophylaxis and the treatment of cosmetic or dermatological skin disorders, such as those that appear as the skin ages.

The cosmetic or dermatological preparations according to the invention may also preferably contain, although not necessarily, fillers, which improve the sensory and cosmetic properties of the formulas and provide, for example, a silky and velvety feel.

or reinforce that feeling on the skin. Preferred fillers in the sense of the present invention are starch, starch derivatives (for example, tapioca starch, starch phosphate, aluminum or sodium starch octenyl succinate 5 and the like), pigments, which either have a coloring effect or act as a UV filter (such as boron nitride etc ...) and / or Aerosiles® (CAS-Nr. 7631-86-9).

 For its application, ball-shaped preparations are applied and rubbed on the skin and / or hair following the usual method of cosmetics.

The cosmetic and dermatological preparations according to the invention may be composed of 10 usual cosmetic and / or dermatological preparations in addition to the components according to the invention, and serve for cosmetic and / or dermatological photoprotection, to modify or influence certain states of the skin, in addition to treatment, skin and / or hair care and as a makeup product in decorative cosmetics.

 According to the topical cosmetic and / or dermatological compositions within the meaning of the present invention and according to their structure, they will be used, for example, as skin care products, skin protective products, sun protection products, hair treatments , day and night care, care of certain areas of the skin such as hands, face, feet, etc ...

 The use of cosmetic preparations in the form of a ball according to the invention also applies to the prophylaxis and treatment of skin aging symptoms, to avoid and reduce the formation and development of wrinkles and folds as well as for the treatment and aged skin care. Thus, a single ball containing ubiquinone, ubiquinol, retinol and derivatives, dehydroepiandrosterone (DHEA), isoflavonoids (insbes, gesinstein, daidzein), creatine, phytoestrogens, estrogens, ostradiol and derivatives, niacinamide, polyphenols (alpha-glucosyl) or other substances effective against wrinkles. 25

 In addition, the use of cosmetic preparations in the form of a ball according to the invention is preferred for the prophylaxis and treatment of dry skin symptoms. The active ingredients suitable for this purpose are: natural oils (soybean oil, evening primrose oil, jojoba oil, macadamia oil, castor oil), ceramides, in particular, Ceramide I, III and VI, cholesterol, phytosterols, acids fatty acids with a chain length of C 16-26, in particular linoleic acid, carnitine and its derivatives, urea, polyols such as glycerin, butylene glycol, propylene glycol and dihydropropylene glycol, pseudoceramides; electrolytes such as sodium chloride and taurine, fatty alcohols as well as waxes.

 In addition, the use of cosmetic preparations in the form of a ball according to the invention is preferable for the prophylaxis and treatment of symptoms of sensitive or inflamed skin. Preferred active ingredients for this purpose are: Milk thistle substances, in particular silymarin, witch hazel extract, chamomile extract, substances inside the sweet stick plant (glycerrhino acid, acetylsalicylic acid, diclofenac, pentacyclic triterpene ( Sericosides, urcolic acid), licochalconas and panthenol.

 In addition, it is preferable to use cosmetic preparations in the form of a ball according to the invention for the prophylaxis and treatment of symptoms of poorly pigmented skin. Preferred active ingredients for this purpose are: tyrosine inhibitors, hydroquinone derivatives, dioic acid, liponic acid and its derivatives as well as kojic acid.

 It is also possible and an advantage to use the compounds according to the invention as the basis of pharmaceutical formulas. The use of cosmetic preparations in the form of a ball according to the invention is preferred for the prophylaxis and treatment of symptoms of diseased skin. Relevant but not exclusively diseased skin conditions are psoriasis, acne, neurodermatitis and other atopic diseases 45 such as atopic dermatitis, skin cancer or melanoma, herpes, mycosis, ichthyosis, pityriasis, seborrhoea, pellagra, eczema of contact and allergies The active ingredients suitable for such application purposes are antibiotics such as fusidinic acid, erythromycin, sulfadiazine, clindamycin, tetracycline, thyrotricine aminoglycoside, bacitracin, chlorophenyl, virustatic (for example, acyclovir, idoxuridine, penciclovir), for example, antifungal niastatina, amphotericin, clotrimazole, econazole, ketoconazole, naftifine, terbinafine), 50 allethrin, cytostatics (5-fluorouracil), antiphlogistics (hydrocortisone, betamethasone, prednisolone, triamcinoloacetónico, dexamethasone, diclofenac, bufexamac), immunosuppressants (cyclosporin A, beta-interferon ), antipsoriatics (ditranol, psoralen, tazarotene), means for acne (retinic acid, isotretinoin, benzoyl peroxide, adapalene); capsaicin, azelaine acid, keratolytics (salicylic acid, lactic acid), antihistamines (azelastine, levocabastine, disodium chromoglycine); antipsoriatics (ditranol, calcitrol, 55 psoralen) and vitamins (in particular, vitamins A, B and C).

 A possible and especially preferred application is to offer in a container the balls with different application purposes, for example, for day and night care, balls with different colors, flavors, different photoprotection intensity factors or different active principles . In said application it is preferable to differentiate the balls of different composition by different shapes.

 Finally, we will not talk about the use of cosmetic preparations in the form of a ball according to the invention for the prophylaxis and treatment of impure skin as well as cellulite.

 The manufacture of ball-shaped preparations according to the invention has been described by way of examples and initially consists in the manufacture of an Ag / Ac emulsion from the essential components of the invention with a method determined according to the application.

 The manufacture of emulsions based on mixed lipid and aqueous phases is well known and is usually carried out by applying mechanical energy and using the appropriate stirring means and homogenizers. Since the emulsions according to the invention are solid at room temperature, all working stages (addition and mixing of substances, homogenization, eventual defoaming by introducing vacuum) must be carried out at temperatures higher than the melting point of the lipid phase. . In general this does not matter if the lipid phase is added initially or the aqueous phase first. If non-optimized installations are used, it is preferable that the lipid phase is placed first for the manufacture of an Ag / Ac emulsion.

 Thus the formula described as example 1 can be manufactured as follows: Ceresin, methyl palmitate, polyethylene, copolymer of PEG-45 / dodecylglycol, polyglyceryl-3 diisoestearate, dimethicone, phenoxyethanol and hexamidine diisethionate are melted and heated to 70 ° C (lipid phase). twenty

Na-EDTA, alpha-glucosylrutin, glycerin, ascorbyl palmitate, dye and citric acid are dissolved in water and the solution is heated to 70 ° C (aqueous phase).

 The aqueous phase is then added by stirring to the lipid phase so that an Ag / Ac emulsion is formed. This sse is cooled by stirring again and gives rise to the perfume at approximately 50 ° C. The stirring is adjusted to approximately 45 ° C and the emulsion is allowed to cool until it finally solidifies. This is the case in the circumstances of a long wait at room temperature since the emulsions according to the invention show tendencies to form a subcooled melt.

 The remaining examples are manufactured in the corresponding way.

  For storage and / or transport, the emulsion thus manufactured can be solidified and then melted again. For the molding of the balls according to the invention, the emulsion melts above its melting point 30 in the corresponding molds or forms and solidifies there, or it is compressed in the pressure molds below its melting temperature.

 The preparation according to the invention has very improved sensory properties that could not be expected from current preparations containing wax. A better distribution, extraction capacity, consistency, sliding through the skin and less adhesion are achieved. With regard to the appropriate methods for determining these parameters, the knowledge of the expert is sought.

 Parameters such as the diameter of the balls will be understood as the diameter in the direction of the longitudinal extent of the ball.

 The following examples clarify the preparations according to the invention. The percentages therefore refer, as long as the opposite is not indicated, to the total mass of the preparations. 40

Example 1

 Ceresina

 6%

 Methyl palmitate

 twenty-one%

 Polyethylene

 3%

 PEG-45 / Dodecyl Glycol Copolymer

 2.5%

 Polyglyceryl-3 Diisoesterate

 1.5%

 Simethicone

 0.5

 Phenoxyethanol

 0.5%

 Hexamidine diisethionate

 0.08%

 EDTA, sodium salt

 0.2%

 alpha-glucosylroutine

 0.2%

 glycerin

 5%

 Ascorbyl palmitate

 0.1

 Colorant

 c.s.

 citric acid

 c.s.

 Fragrance

 c.s.

 Water

 up to 100

Example 2

 Ozokerite

 3%

 Shea butter

 twenty-one%

 Polyethylene

 3%

 PEG-45 / Dodecyl Glycol Copolymer

 one%

 Polyglyceryl-3 Diisoesterate

 one%

 Bis-ethylhexyloxyphenol methoxyphenyl triazine

 2%

 Octylmethoxycinnamate

 5%

 Simethicone

 0.5

 Phenoxyethanol

 0.5%

 Paraben

 0.08%

 Urea

 3%

 Glycerin

 6%

 Lactic acid

 c.s.

 Colorant

 c.s.

 Fragrance

 c.s.

 Water

 up to 100

Example 3

 Hydrated Coconut Glyceride

 10%

 Capryl / caprinyl triglycerides

 25%

 Polyethylene

 3%

 Eucerit

 3.0%

 TiO2

 2%

 Aerosil R 812

 one%

 Dekaben LMB

 0.5%

 Phenoxyethanol

 0.3%

 Ubiquinone

 0.1%

 Butylene glycol

 3.0%

 Glycerin

 4%

 Panthenol

 3.0%

 Citric acid

 c.s.

 NaOH

 c.s.

 Fragrance

 c.s.

 Water

 up to 100

Example 4

 Myristyl myristate

 fifteen%

 Cetyl Ricinoleate

 twenty%

 Ceresina

 5%

 Polyglyceryl-3 Diisoesterate

 1.5%

 Polyglyceryl Dipolyhydroxystearate-2

 1.5%

 Mica

 2%

 DMDM hydantoin

 0.2%

 Phenoxyethanol

 0.4%

 Creatine

 0.3%

 Creatinine

 0.1%

 Niacinamide

 0.2%

 Glycerin

 5%

 Fragrance

 c.s.

 Water

 up to 100

Example 5

 Liquid paraffin

 fifteen%

 Hydrated vegetable fat

 fifteen%

 Microcrystalline wax

 10%

 Eucerit

 one%

 Polyglyceryl Dipolyhydroxystearate-2

 1.5%

 Nylon

 2%

 Magnesium stearate

 0.5%

 Ethylhexyloxyglycerin

 0.5%

 Phenoxyethanol

 0.5%

 Paraben

 0.6%

 Retinyl palmitate

 0.2%

 Panthenol

 one%

 Glycerin

 5%

 Fragrance

 c.s.

 Water

 up to 100

Example 6

 Liquid paraffin

 fifteen%

 Hydrated vegetable fat

 fifteen%

 Microcrystalline wax

 10%

 Polyglyceryl-3 Diisoesterate

 one%

 PEG-45 / Dodecyl Glycol Copolymer

 2%

 Starch octenyl succinate

 one%

 Magnesium stearate

 0.5%

 Methylpropanediol

 0.5%

 Phenoxyethanol

 0.3%

 Paraben

 0.3%

 Creatine

 0.2%

 Tocopheryl acetate

 0.5%

 Glycerin

 5%

 Ferric oxide pigment

 one%

 Fragrance

 c.s.

 Water

 up to 100

Claims (15)

1. Cosmetic and / or dermatological preparation based on an Ag / Ac emulsion in the form of stable and / or rigid balls or spheroids, semi-rigid at a temperature of 35 ° C with a volume of 0.1 to 20 ml containing basically lipids, emulsifiers , natural and / or synthetic polymers and / or mixtures thereof, characterized in that the preparation consists of a stable mixture in the form of a lipid / emulsifier, the dispersed water with a droplet size of less than 50 micrometers. 5

2. Prepared according to claim 1, characterized in that the waxes are chosen from the group of cetyl palmitate, cetyl ricinoleate, beeswax, hydrated cocoglyceride, methyl palmitate, Candelilla wax, Carnauba wax, paraffin wax , ceresin, ozokerite, myristyl myristate, tripalmitin, tribehenin, glyceryl palmitosterate, hydrated rapeseed oil, and C15-40 alkylstearyl stearate.

3. Prepared according to one of claims 1 or 2, characterized in that the preparation 10 contains waxes that are chosen from microcrystalline waxes, paraffin waxes, ester waxes, glyceride waxes, as well as fatty alcohols and solid emulsifiers and their mixtures

4. Prepared according to one of the preceding claims, characterized in that it has an average diameter of 3 to 40 mm.

5. Prepared according to one of the preceding claims, characterized in that it also contains auxiliary substances, UV filters, pigments, active substances, colorants, sensory additives, thickeners, gel-forming agents, preservative media, antioxidants, complexing agents. , taste substances, denaturants, active ingredients and / or perfume.

6. Prepared according to one of the preceding claims, characterized in that each of the preparations in the form of balls is coated in an envelope with an outer packaging cover. twenty

7. Prepared according to one of the preceding claims, characterized in that the ball-shaped preparations are individually packaged or several in paper, metal or plastic packaging.

8. Prepared according to one of the preceding claims, characterized in that the preparations in the form of balls are individually packaged or several packaged in the form of paper, metal or plastic blister packs. 25

9. Prepared according to one of the preceding claims with a blister pack for the individual extraction of each of the preparations in the form of balls.

10. Use of the preparation according to one of the preceding claims for topical application on the skin and / or hair.

11. Use of the preparation according to claim 10 to apply the cosmetics without leaving residues. 30

12. Use of the preparation according to claim 10 or 11 for individual application.

13. Method for the application of cosmetic and / or dermatological preparations according to one of claims 1 to 9 for topical application, so that the preparations when rubbing and spreading through the skin and / or hair

- merge and / or 35

- due to the shear forces they are totally or partially liquefied and / or

- they dissolve completely or partially in the skin sebum lipids.

14. Method for applying cosmetic and / or dermatological preparations according to claim 13 so that one or more ball-shaped preparations are removed from a container and applied by rubbing the skin and / or hair. 40

15. A combination consisting of several ball-shaped preparations according to one of claims 1 to 9, characterized in that at least two of the ball-shaped preparations differ in appearance, have different contents and / or serve to different purposes