ES2352101T3 - USE OF 25-HYDROXY-VITAMIN TO D3, TO IMPROVE THE VITALITY OF ANIMALS. - Google Patents

Abstract

The use of 25-hydroxy-Vitamin D3 in the manufacture of a feed supplement to increase the number per litter and the vitality of young animals in animal husbandry and to provide better body structure and increase loin fat gain during pregnancy, reduce the loss of fat from the loin during lactation and increase the intake of feed during lactation of female animals.

Description

Use of 25-hydroxy-vitamin D 3 for Improve the vitality of animals.

The present invention relates to the use of 25-hydroxy-Vitamin D 3 for improve the general state of health of female animals during pregnancy and / or lactation.

The present invention also relates to the use of 25-hydroxy-Vitamin D 3 in Animal reproduction More particularly, the invention is refers to the use of 25-hydroxy-Vitamin D 3 for increase the number of piglets per litter and the vitality of piglets in pig farming and to provide better structure body and increase loin fat gain during gestation, reduce loin fat loss during breastfeeding and increase feed intake during breastfeeding Marrana and young sows.

The main purpose of pig farming is produce the maximum number of piglets weaned per pig and per year at minimum cost. Any small increase in productivity of the marrana will have a significant significant positive impact on the reproductive efficiency of the total breeding herd and on the overall profitability of the pig company. For example, a simple increase of 0.2 piglets weaned by marrana and per year translates into an additional contribution of 200 market piglets in a scenario of 1000 parrots until the end of the operation.

It is fully recognized that there is a wide variation of the productivity of the pigs in the herds of pig farming within and between countries and regions. From piaras low to high productivity, the number per litter of live born piglets ranges from 7 to 13 and the number per litter of weaned piglets between 5 and 12. Therefore, there is considerable potential to improve the productivity of the pigs.

Reproductive efficiency is influenced notably because of the very variable loss of potential piglets during the course of pregnancy. 15 to 20% of fetuses are they lose between days 30 and 50 of gestation and there is a loss additional 5 to 10% from day 90 to 114. Losses in the initial part of pregnancy can be precipitated by factors that influence implantation (interaction between the embryo and the uterus), while those corresponding to the final part of the pregnancy are limited by available uterine space by piglet, which is more likely a limiting factor in the pigs younger.

The number per litter is the fundamental parameter which affects the number of piglets born alive and weaned by Marrana and per year. Genetic improvements, the new management of Young bristles and modern production management techniques they are practical approaches that are used to increase the number by litter and productivity of breeding herds. From the point of view of reproductive physiology, a rational approach to increase the number per litter in piglets has to be compatible with successful implementation and sustainable pregnancy and an increase in uterine capacity by way of increased length of the uterine tubes during the course of pregnancy. Additionally, the pigs that produce litters of greater number they must have satisfactory milk production characteristics to be able to raise additional piglets and keep them nutritionally in terms of health and development during the course of breastfeeding so that the increase in the number of pigs weaned per litter.

Uses of Vitamin D3 to improve reproduction in the Animals are described in US 4970203 and JP 2005/192514

The present invention is defined by the claims.

In accordance with the present invention, it has been found that the administration of 25-hydroxy-Vitamin D 3 at female animals, for example pigs and young sows, increases the number per litter of live-born piglets and piglets weaned and therefore improves the vitality of piglets produced from pregnant pigs and young sows as well fed. Vitality is reflected in the increase in the number by litter by an increase in the number of piglets born alive and the number of weaned piglets. In another aspect, the use of 25-hydroxy-Vitamin D 3 gives as result the production of healthier piglets that survive better than those of the pigs fed without 25-hydroxy-Vitamin D 3, as it is evidenced by a reduced mortality of piglets during lactation. It has also been found that the administration of 25-hydroxy-Vitamin D 3 at young pigs and pigs, respectively, provides better body structure and increases loin fat gain during pregnancy reduces fat loss during breastfeeding and increases feed intake during breastfeeding and young sows.

Thus, in one aspect, the invention relates to to the use of 25-hydroxy-Vitamin D_ {3} in the manufacture of a food supplement for increase the number per litter in animal reproduction, for example in pig farming. In another aspect, the invention relates to use of 25-hydroxy-Vitamin D 3 in the manufacture of a food supplement to increase the vitality of young animals, for example piglets, by administration of an effective amount of 25-hydroxy-Vitamin D 3 at Marranas and young sows.

In another aspect, the invention relates to the use of 25-hydroxy-Vitamin D 3 in the manufacture of a food supplement to improve the state general health of female animals at least during pregnancy and / or lactation, which means providing better body structure and / or increase loin fat gain during pregnancy, and / or reduce loin fat loss during breastfeeding and / or increase feed intake during Lactation of female animals.

In the context of the invention, the term "animals" means animals including mammals, examples of which include humans. Preferred examples of mammals in addition to humans are ruminant and non-ruminant animals, for example cattle, pets such as dogs and cats, horses, camels, sheep, goats and
pigs

The term "marranas" as used in this memory includes young sows, that is female pigs that they are destined to be fertilized and have never been pregnant by the male pig, as well as parity sows 1, which can be done reference also as primiparous maran; and multiparous pigs, that is, pigs that have given birth to more than one litter.

The term "best body structure" denotes an increase in the number of young sows that satisfy the standard body condition after the efficiency test and evaluation as measured by the registration system for evaluation of the structure of the legs and legs according to the "Guidelines for Uniform Swine Improvement Programs" (National Swine Improvement Federation, NSIF, 1996), evaluation from "Feet and Leg Soundness in Swine" (Pork Industry Handbook, PIH 101) and the evaluation of the sizes of the toes of the legs and The hooves.

As used herein, the term food product refers to any suitable feed or feed  for consumption by humans or animals. The food product can be a product prepared and packaged for human consumption or feed supplement or animal feed (e.g. animal feed extruded and pelletized, coarse grain mixed feed or composition for pet food). The term I think also includes feed as both solid and liquid as well as drinking liquids such Like drinking water

For human consumption in order to improve the general state of health of a mother during pregnancy and / or the breastfeeding, a food supplement can be administered according with the invention in the form of unit doses, for example tablets, capsules, dosed powders, or liquid portions dosed, which may, if desired, be carbonated. Additionally, food supplements of the invention can contain inert and physiologically conventional vehicles acceptable, flavoring agents, coloring agents and calcium. By example, a tablet can be supplemented with 25-hydroxy-Vitamin D 3 in a amount that satisfies a daily dose of 25-hydroxy-Vitamin D 3 from approximately 5 to 15 mcg per kg of body weight, the dose being Usual daily one or two tablets.

In the following the invention is described with greater detail with reference to animal reproduction.

For the purposes of the invention, conveniently manage 25-hydroxy-Vitamin D3 as feed supplement. The feed can be supplemented by incorporation of 25-hydroxy-Vitamin  D_ {3}, e.g., as a commercial formulation as it is available under the trademark ROVIMIX® Hy-D® 1.25% to normal feed or by first preparation of a premix of a feed component and 25-hydroxy-Vitamin D 3 and subsequent mixing of the premix with other components of the I think. The feed can be any conventional feed for pigs The term I think as used herein includes solid and liquid feed as well as drinking fluids such like drinking water Particularly, the 25-hydroxy-Vitamin D 3 can be added as a formulated powder to a premix containing other minerals, vitamins, amino acids and trace elements, premix that it is added to the normal feeding of the animals and mixed conscientiously to achieve a uniform distribution in the same.

For the purposes of the invention, the 25-hydroxy-Vitamin D 3 se administered at least one stage of the reproductive cycle (pregnancy and lactation) and is conveniently administered also in the development of young replacement sows, that is the development of female pigs selected to replace the sows slaughtered in the breeding herd.

Generally the 25-hydroxy-Vitamin D 3 se add to the feed of the pigs in an amount required to administer from about 0.1 mcg to about 3.0 mcg, especially about 0.5 mcg to about 2.0 mcg of 25-hydroxy-Vitamin D 3 per kg of body weight of an individual animal per day.

More specifically, in the manufacture of a I think for young / brown bristles according to the invention, it conveniently added from about 10 mcg / kg to approximately 100 mcg / kg of 25-hydroxy-Vitamin D 3 al I think normal pigs. Alternatively, a feed premix based on normal components of the I think by adding active ingredients to these components of the I think in greater concentration, e.g. in a concentration of about 10 mg / kg to about 100 mg / kg of 25-hydroxy-Vitamin D 3. Whether add 1 kg of this premix per 1000 kg of normal feed, would typically meet the individual need of the animal for normal feed intake.

Based on the requirements of the sows young individuals and pregnant pigs, is administered conveniently 25-hydroxy-Vitamin  D 3 for the purposes of the invention in amounts of approximately 0.125 mcg to approximately 1,250 mcg, especially approximately 0.625 mcg to approximately 1,000 mcg per kg of body weight and per day. So, the 25-hydroxy-Vitamin D 3 se conveniently add to the feed in an amount that satisfies said dosage requirement. Typically, a feed for Young sows and pregnant pigs can contain from approximately 10 mcg to approximately 100 mcg, especially from approximately 50 mcg to approximately 80 mcg of 25-hydroxy-Vitamin D 3 per kg of feed

Additionally, based on the requirements of the individual lactating pigs, it is administered conveniently 25-hydroxy-Vitamin D 3 for the purposes of the invention in amounts of approximately 0.250 mcg at approximately 2,500 mcg, especially approximately 1,250 mcg at approximately 2,000 mcg per kg of body weight and per day. Thus, it is conveniently added 25-hydroxy-Vitamin D 3 al I think of an amount that meets that requirement of dosage. Typically, a feed for lactating pigs can contain from about 10 mcg to about 100 mcg, in special from about 50 mcg to about 80 mcg of 25-hydroxy-Vitamin D 3 per kg of feed

To calculate body weight and ingestion of I think of young sows and pregnant pigs, you can be considered an average of 200 kg of body weight and 2.5 kg of I think per day. For the calculation of body weight and ingestion of I think of lactating pigs can be considered an average of 200 kg of body weight and 5 kg of feed per day.

The efficiency of the bristle treatment young people according to the invention can be deduced from both experiments described below.

Experiment one

On a commercial swine farm, it they selected a total of 27 young replacement sows of 6 Months of age (native variety x Large White). Two followed dietary treatments at different stages of the cycle Reproductive (development of young replacement sows, pregnancy, lactation). The control diet was the standard diet of the farm without the supplement of 25-hydroxy-Vitamin D 3. The experimental diet was the standard diet of the supplemented farm with 25-hydroxy-Vitamin D 3 a 50 mcg ratio per kg of diet.

Fourteen (14) were randomly selected young sows and were assigned to the control group, and the other thirteen young sows to the ROVIMIX® Hy-D® group 1.25% Reproduction began when young sows had An age of 7 months. They put them in the stables of pregnancy after reproduction and remained in them up to 14 days before the expected date of delivery. They weighed later the bristles and they took to the birthing stables. The piglets are weaned at 28 days of age.

Experiment 2

In another commercial pig farm you they selected a total of 43 young replacement sows of 6 Months of age (native variety x Large White). Two followed dietary treatments at different stages of the cycle reproductive (reproductive development of young sows, pregnancy, lactation). The control diet was the standard diet of the farm without the supplement of 25-hydroxy-Vitamin D 3. The experimental diet was the standard diet of the supplemented farm with 25-hydroxy-Vitamin D 3 a 50 mcg ratio per kg of diet.

Twenty-two were randomly selected (22) young sows and were assigned to the control group and the other twenty one young sows to the ROVIMIX® Hy-D® group 1.25% Reproduction began when young sows had An age of 7 months. They put them in the stables of pregnancy after reproduction and remained in them up to 14 days before the expected date of delivery. They weighed later and they took to the birthing stables. The piglets weaned at 28 days old

The following data were collected in the delivery stables for experiments 1 and 2.

one.

Number per litter at birth

to.

Total born piglets

b.

Live born piglets

C.

Pigs born dead

d.

Mummified Fetuses

2.

Weight of piglets at birth

3.

Number per litter at weaning

Four.

Mortality

5.

Weight of piglets at weaning.

Table 1 (experiment 1) shows that the reproductive efficiency of primiparous piglets fed with 25-hydroxy-Vitamin D 3 had greater number per litter at birth both in terms of piglets totals born (10.46 versus 9.00; + 1.46) as piglets live births (9.77 versus 7.93 + 1.84) than young sows that had been fed with rationed feed without the 25-hydroxy-Vitamin D 3 supplementary (control). The number per litter at weaning was also larger for the group treated with 25-hydroxy-Vitamin D 3 which for the control group (9.46 vs. 7.64 + 1.82). The group of control, however, had a greater birth weight (1.64 versus 1.45 kg). Weaning weights were no different from each other. Without However, piglets of young sows fed with 25-hydroxy-Vitamin D 3 won 5.5 kg versus 5.33 kg for those of the young sows of the group of control at the time of weaning at 28 days.

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TABLE 1 Reproductive efficiency of primiparous pigs fed with 25-hydroxy-Vitamin D 3 (experiment 1)

one

LSBT = Number per litter of total piglets at birth; LSBA = Number per litter of total piglets born alive BWT = Body weight of piglets at birth; LSW = Number total pigs weaned at weaning at 28 days; WWT = Weight body weaning at 28 days.

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TABLE 2 Reproductive efficiency of primiparous pigs fed with 25-hydroxy-Vitamin D 3 (experiment 2)

2

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Table 2 (experiment 2) shows that the reproductive efficiency of primiparous piglets fed with 25-hydroxy-Vitamin D 3 had higher number per litter of live-born piglets (9.62 versus 9.18; + 0.44) than those that were fed a ration that lacked of 25-hydroxy-Vitamin D 3 supplementary (control). The number per litter at weaning was also larger for the group treated with 25-hydroxy-Vitamin D 3 which for the control group (8.48 vs. 7.82 + 0.66).

The invention is further illustrated by the Examples that follow.

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Example one

A feed that understood the components that shown in Table 3 below is supplemented with 50 to 80 mcg of 25-hydroxy-Vitamin D 3 per kg of feed

3

4

A feed like the one specified above is Supplement with 25-hydroxy-Vitamin D 3 per mixture of 50 to 80 mg of 25-hydroxy-Vitamin D 3 (4 a 6.4 g of ROVIMIX® Hy-D® 1.25% as it is supplied by DSM Nutritional Products, Kaiseraugst, Switzerland) along with the remaining elements of the feed. I think pasta obtained can be pelletized, if necessary.

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Example 2

A feed is prepared as indicated in the Example 1, except that approximately 50 to 80 mg of 25-hydroxy-Vitamin D 3 per kg of premix of Vitamins and minerals.

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Example 3

A feed premix can be prepared to feeding of young or brown bristles it contains 25-hydroxy-Vitamin D 3, as follow:

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5

6

All ingredients are mixed together carefully and 0.5% (5 kg / 1000 kg of feed) is added to this premix to a conventional feed for pigs or sows young boys.

Alternatively, it can also be added 25-hydroxy-Vitamin D 3 in a 1% diluted premix, which contains a suitable vehicle. Saying vehicle can be wheat flour, wheat rind, carozos de corn, rice husk, almond husks or carbonate calcium alone or in variable mixtures of several of these vehicles. A typical formulation is:

7

All ingredients are mixed carefully each other and add 0.05% (0.5 kg / 1000 kg of feed) of this premix to a conventional feed for pigs or young sows, thus providing 50 mcg of 25-hydroxy-Vitamin D 3 per kg of feed

Claims (8)

1. The use of 25-hydroxy-Vitamin D 3 in the manufacture of a feed supplement to increase the number by litter and vitality of young animals in animal husbandry and to provide better body structure and increase the loin fat gain during pregnancy, reduce loss of loin fat during breastfeeding and increase ingestion of I think while breastfeeding female animals. 2. The use of 25-hydroxy-Vitamin D 3 in the manufacture of a feed supplement in accordance with the claim 1, to increase the number per litter and vitality of piglets in pig farming and to provide better body structure and increase loin fat gain during gestation, reduce loin fat loss during breastfeeding and increase feed intake during breastfeeding Marranas and young sows. 3. The use of 25-hydroxy-Vitamin D 3 of according to claim 2 to increase the number per litter and the vitality of piglets in pig farming. 4. The use according to claim 2 or 3 in which it is administered 25-hydroxy-Vitamin D 3 a Marranas or young sows as a feed supplement. 5. The use according to claim 4 in which is added 25-hydroxy-Vitamin  D_ {3} to feed in an amount required to administer from about 0.1 mcg to about 3.0 mcg, especially approximately 0.5 mcg to approximately 2.0 mcg of 25-hydroxy-Vitamin D 3 per kg of body weight of an individual animal per day. 6. The use according to claim 4 in which is added 25-hydroxy-Vitamin  D 3 to feed in an amount of approximately 10 mcg at approximately 100 mcg, especially from approximately 50 mcg to approximately 80 mcg per kg of feed. 7. Use in accordance with any one of the claims 2-6 in which the marrana is a Young sow or pregnant pig. 8. Use in accordance with any one of the claims 2-6 in which the marrana is a lactating marrana