ES2337758B1 - PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ANDROPENIA / ANDROPAUSIA. - Google Patents

PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ANDROPENIA / ANDROPAUSIA. Download PDF

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Publication number
ES2337758B1
ES2337758B1 ES201030083A ES201030083A ES2337758B1 ES 2337758 B1 ES2337758 B1 ES 2337758B1 ES 201030083 A ES201030083 A ES 201030083A ES 201030083 A ES201030083 A ES 201030083A ES 2337758 B1 ES2337758 B1 ES 2337758B1
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treatment
andropenia
andropause
composition
pharmaceutical composition
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ES2337758A1 (en
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Cesar Quintanilla Ripoll
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LABORATORIOS Q PHARMA SL
Q PHARMA S L LAB
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LABORATORIOS Q PHARMA SL
Q PHARMA S L LAB
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L1/302—
    • A23L1/304—
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composición farmacéutica para el tratamiento de la andropenia/andropausia.Pharmaceutical composition for the treatment of Andropenia / Andropause

La composición se materializa en un complemento o suplemento nutricional, cuya posología es de un comprimido al día y su absorción por vía oral, incorporando dicha composición micronutrientes, vitaminas y minerales, con una concentración determinada, concretamente vitaminas A, B1, B2, BP, B6, B8, B9, B12, C, D3, E y K, así como calcio, cobre, hierro, licopeno, magnesio, manganeso, fósforo, selenio y zinc. Se consigue de esta manera una composición para tratamiento de la andropenia/andropausia, que viene a ocupar un vacío en este campo, donde en la actualidad no existe ningún tratamiento estandarizado y eficaz.The composition materializes in a complement or nutritional supplement, whose dosage is one tablet per day and its absorption orally, incorporating said composition micronutrients, vitamins and minerals, with a concentration determined, specifically vitamins A, B1, B2, BP, B6, B8, B9, B12, C, D3, E and K, as well as calcium, copper, iron, lycopene, magnesium, manganese, phosphorus, selenium and zinc. You get this way a Composition for treatment of andropenia / andropause, which comes to occupy a void in this field, where there is currently no No standardized and effective treatment.

Description

Composición farmacéutica para tratamiento de la andropenia/andropausia.Pharmaceutical composition for the treatment of andropenia / andropause.

Objeto de la invenciónObject of the invention

La presente invención se refiere a mía nueva composición farmacéutica especialmente concebida como tratamiento o como atenuante en la andropenia/andropausia, también denominada "Síndrome de deficiencia androgénica del anciano".The present invention relates to mine new pharmaceutical composition specially designed as a treatment or as an attenuator in andropenia / andropause, also called "Androgenic deficiency syndrome of the elderly".

De forma mas concreta, el objeto de la invención es un método para prevenir y/o tratar los trastornos producidos por la andropenia/andropausia, mediante la administración de suplementos nutricionales, en forma de comprimidos que, tras su administración y absorción oral, mejoren o ayuden a mejorar al sujeto en cuestión, concretamente en los siguientes aspectos:More specifically, the object of the invention It is a method to prevent and / or treat disorders caused by andropenia / andropause, by supplement administration nutritional, in the form of tablets that, after administration and oral absorption, improve or help improve the subject in question, specifically in the following aspects:

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Disminución del estado de fatiga.Decreased state of fatigue.

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Mejora de la vida sexual del paciente.Improvement of the patient's sexual life.

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Mejora de su estado de ánimo.Improvement of your mood. 

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Antecedentes de la invenciónBackground of the invention

La andropenia/andropausia se caracteriza por una disminución de las hormonas sexuales masculinas a partir de cierta edad y, aunque no se encuentre claramente definida como otras patologías similares como es el caso de la menopausia, si presenta una sintomatología bien conocida. Específicamente los síntomas que aparecen causados por una disminución hormonal son los siguientes:Andropenia / andropause is characterized by a decrease in male sex hormones from certain age and, although not clearly defined as others similar pathologies such as menopause, if it presents a well known symptomatology. Specifically the symptoms that appear caused by a hormonal decrease are the following:

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Disminución de la libido o deseo sexual.Decreased libido or desire sexual.

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Reducción de la calidad de las erecciones.Reduction of the quality of erections

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Depresión del estado de ánimo.Depression of mood.

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Fatiga.Fatigue. 

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La terapia hormonal sustitutiva masculina no está muy extendida, al contrario de lo que ocurre entre respectiva para las mujeres; sin embargo puede ser de gran ayuda para aquellos hombres que conjuntamente con su médico decidan llevarla a cabo. La terapia hormonal sustitutiva a largo plazo, tiene como finalidad eliminar o amortiguar los síntomas de la andropausia, incrementar las ganas de vivir, mantener el vigor físico y la capacidad intelectual, dándole un especial enfoque a restaurar las funciones sexuales.Male hormone replacement therapy does not It is very widespread, contrary to what happens between respective for the women; however it can be a great help for those men who together with their doctor decide to carry it out. The Long-term replacement hormone therapy, is intended eliminate or cushion the symptoms of andropause, increase the desire to live, maintain physical vigor and ability intellectual, giving a special focus to restore functions sexual.

Kaufman JM et al, mediante el artículo publicado en la revista Endocrine Reviews; 26 (6): 833-876 de 2005 y cuyo título es "The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications" explica como la necesidad de tratamiento mediante terapia sustitutiva y las condiciones que el sujeto ha de cumplir para que sea susceptible de seguir dicho tratamiento.Kaufman JM et al , through the article published in the journal Endocrine Reviews; 26 (6): 833-876 of 2005 and whose title is "The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications" explains how the need for treatment by substitute therapy and the conditions that the subject has to meet for be able to follow such treatment.

Este tratamiento conlleva unos riesgos que quedan claramente definidos en el artículo escrito por Gruenewald DA et al, denominado "Testosterone supplementation therapy for older men: potential benefits and risks" de J Am Geriatr Soc. 2003 Jan; 51(1):101-15; discussion 115.This treatment involves risks that are clearly defined in the article written by Gruenewald DA et al , called "Testosterone supplementation therapy for older men: potential benefits and risks" by J Am Geriatr Soc. 2003 Jan; 51 (1): 101-15; discussion 115.

Mediante estos artículos queda demostrado la necesidad de buscar un tratamiento coadyudante, en algunos casos severos, o principal en casos donde el sujeto no tenga una disminución importante de las hormonas sexuales.Through these articles the need to seek an adjunctive treatment, in some cases severe, or principal in cases where the subject does not have a significant decrease in sex hormones. 

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Descripción de la invenciónDescription of the invention

La invención propuesta pretende, no establecer los niveles hormonales, sino que pretende tratar la sintomatología resultante del déficit de testosterona. Los componentes que forman parte de la invención propuesta, junto con el licopeno, tienen una acción antioxidante, la cual minimizará el desgaste fisiológico, ayudando a que el sujeto no se encuentre en un estado de fatiga y/o depresión de ánimo que aparecen en hombre con andropenia/andropausia.The proposed invention aims not to establish hormonal levels, but aims to treat symptomatology resulting from testosterone deficit. The components that form part of the proposed invention, together with lycopene, have a antioxidant action, which will minimize physiological wear, helping the subject is not in a state of fatigue and / or mood depression that appear in men with andropenia / andropause.

Como hemos citado anteriormente, uno de los trastornos relacionados con la andropenia/andropausia es la fatiga. La invención propuesta aporta una serie de nutrientes necesarios, que junto a los nutrientes obtenidos a través de la dieta diaria, ayudan a tratar dicho trastorno que puede ser causado por una disminución de la actividad hormonal o por la edad.As we mentioned above, one of the Andropenia / Andropause related disorders is fatigue. The proposed invention provides a series of necessary nutrients, that together with the nutrients obtained through the daily diet, they help treat such a disorder that can be caused by a decreased hormonal activity or age.

Ya existen otros complementos vitamínicos que se utilizan como aporte nutricional, sin embargo, la invención propuesta está diseñada para aportar las vitaminas, minerales y otros componentes específicos que necesitaría un sujeto que padece andropenia/andropausia.There are already other vitamin supplements that are they use the invention as a nutritional contribution, however proposal is designed to provide vitamins, minerals and other specific components that a subject suffering from would need andropenia / andropause.

De forma mas concreta se trata de una composición, utilizable como un complemento o suplemento nutricional, composición que alberga desde micronutrientes a vitaminas y minerales, en una proporción determinada, para el tratamiento de los trastornos anteriormente citados y relacionados con la andropenia/andropausia.More specifically it is a composition, usable as a supplement or supplement nutritional, composition that houses from micronutrients to vitamins and minerals, in a certain proportion, for the treatment of the aforementioned and related disorders with andropenia / andropause.

Específicamente el citado complemento o suplemento nutricional está destinado a ser consumido en forma de comprimido, con una posología de un comprimido/día y cuya absorción es por vía oral.Specifically the aforementioned complement or Nutritional supplement is intended to be consumed in the form of tablet, with a dosage of one tablet / day and whose absorption It is oral.

Los componentes de la composición farmacéutica y la cantidad de cada uno de ellos que participa en cada comprimido, con rango comprendido entre valores máximos y mínimos, viene detallada en la siguiente tabla:The components of the pharmaceutical composition and the amount of each of them participating in each tablet, with a range between maximum and minimum values, it comes detailed in the following table: 

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1one 

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Ejemplo de realización prácticaExample of practical realization

De acuerdo con un ejemplo preferente de realización, en un comprimido de la aludida composición farmacéutica participan los siguientes compuestos en las cantidades que se reflejan y con sus respectivos índices CDR (Cantidad Diaria Recomendada).According to a preferred example of embodiment, in a tablet of said pharmaceutical composition the following compounds participate in the amounts that are reflect and with their respective CDR indices (Daily Amount Recommended)

22

Claims (1)

1. Composición farmacéutica para tratamiento de la andropenia/andropausia, que constituyendo un complemento o suplemento nutricional cuya posología es de un comprimido al día y su absorción es por vía oral, se caracteriza porque en cada comprimido participan los siguientes compuestos en las siguientes cantidades:1. Pharmaceutical composition for the treatment of andropenia / andropause, which constitutes a nutritional supplement or supplement whose dosage is one tablet per day and its absorption is oral, characterized in that the following compounds participate in each tablet in the following amounts: 33
ES201030083A 2010-01-25 2010-01-25 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ANDROPENIA / ANDROPAUSIA. Active ES2337758B1 (en)

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ES201030083A ES2337758B1 (en) 2010-01-25 2010-01-25 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ANDROPENIA / ANDROPAUSIA.

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ES201030083A ES2337758B1 (en) 2010-01-25 2010-01-25 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ANDROPENIA / ANDROPAUSIA.

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ES2337758B1 true ES2337758B1 (en) 2011-02-10

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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571441A (en) * 1994-11-01 1996-11-05 The Procter & Gamble Company Nutrient supplement compositions providing physiologic feedback
DK1155620T3 (en) * 2000-05-18 2005-12-05 Mega Healthcare As Q Dietary supplement with vitamins, minerals and polyunsaturated fatty acids
US7332181B1 (en) * 2003-09-05 2008-02-19 Glu-Pro, Inc. Composition for managing diabetes, obesity, and hyperlipidemia and associated methods
US8491937B2 (en) * 2007-02-15 2013-07-23 Wyeth Llc Stability in vitamin and mineral supplements

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