ES2296527A1 - Medical kit and set of instruments for performing a home test for the detection of precursor lesions of cervical cancer - Google Patents
Medical kit and set of instruments for performing a home test for the detection of precursor lesions of cervical cancer Download PDFInfo
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- ES2296527A1 ES2296527A1 ES200602056A ES200602056A ES2296527A1 ES 2296527 A1 ES2296527 A1 ES 2296527A1 ES 200602056 A ES200602056 A ES 200602056A ES 200602056 A ES200602056 A ES 200602056A ES 2296527 A1 ES2296527 A1 ES 2296527A1
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- 238000012360 testing method Methods 0.000 title claims abstract description 16
- 238000001514 detection method Methods 0.000 title claims abstract description 15
- 239000002243 precursor Substances 0.000 title claims abstract description 12
- 206010008342 Cervix carcinoma Diseases 0.000 title claims abstract description 11
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 title claims abstract description 11
- 201000010881 cervical cancer Diseases 0.000 title claims abstract description 11
- 230000003902 lesion Effects 0.000 title claims abstract description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 18
- 230000002380 cytological effect Effects 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 3
- 241000701806 Human papillomavirus Species 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 7
- 210000001215 vagina Anatomy 0.000 abstract description 6
- 210000003679 cervix uteri Anatomy 0.000 abstract description 5
- 206010028980 Neoplasm Diseases 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 201000011510 cancer Diseases 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 5
- 238000012216 screening Methods 0.000 description 3
- 241001631646 Papillomaviridae Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000009595 pap smear Methods 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 241000544076 Whipplea modesta Species 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 208000026037 malignant tumor of neck Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000009863 secondary prevention Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0074—Vaginal or cervical secretions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B2010/0216—Sampling brushes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Dispositivo aplicable a la realización de autotest para detección de lesiones precursoras de cáncer de cuello uterino.Device applicable to the realization of self-test for detection of neck cancer precursor lesions uterine.
La invención, tal como expresa el enunciado de la presente memoria descriptiva, se refiere a un dispositivo aplicable a la realización de autotest para detección de lesiones precursoras de cáncer de cuello uterino, que aporta a la función a que se destina ventajas y características, además de las inherentes a su organización y constitución, que se describirán en detalle más adelante, y que suponen una innovadora mejora a lo ya conocido en este campo.The invention, as expressed in the statement of The present specification refers to a device applicable to performing self-test for injury detection precursors of cervical cancer, which contributes to the function of that advantages and features are destined, in addition to the inherent to its organization and constitution, which will be described in detail later, and that represent an innovative improvement to what is already known in this field.
De forma más concreta, el objeto de la invención consiste en un dispositivo destinado a permitir a las mujeres realizar de forma autónoma, en su propio domicilio y de forma privada, un autotest de detección de las lesiones precursoras del cáncer de cuello uterino, estando constituido por un conjunto de elementos que permiten, de forma fácil y sencilla, la recogida de células de la vagina y de su almacenamiento en medio líquido, para su posterior estudio citológico por parte de un laboratorio apropiado.More specifically, the object of the invention consists of a device intended to allow women perform autonomously, in their own home and of privately, a self-test for detecting precursor lesions of cervical cancer, being constituted by a set of elements that allow, in an easy and simple way, the collection of cells of the vagina and their storage in liquid medium, for subsequent cytological study by a laboratory appropriate.
El campo de aplicación de la presente invención es el de la medicina preventiva, y más concretamente el de la industria dedicada a la fabricación de aparatos, elementos y dispositivos terapéuticos o de prevención.The field of application of the present invention it is that of preventive medicine, and more specifically that of industry dedicated to the manufacture of apparatus, elements and therapeutic or prevention devices.
Como es sabido, la citología cervical ha demostrado ser un método eficaz para reducir la mortalidad por cáncer de cérvix debido a que detecta lesiones precursoras del mismo.As is known, cervical cytology has proven to be an effective method to reduce mortality from cervical cancer because it detects precursor lesions of the same.
Debemos destacar, que es el tercer cáncer en frecuencia en los países desarrollados, después del de mama y el de colon, y el segundo en los países menos desarrollados.We must highlight, which is the third cancer in frequency in developed countries, after breast and colon, and the second in less developed countries.
Tal como se conoce actualmente, aplicada a los métodos de "screening", es una prueba de bajo coste pero también de baja sensibilidad (en las mejores series alcanza un 51-59%), es decir, tiene una enorme cantidad de falsos negativos, o lo que es lo mismo, muy baja capacidad para detectar el cáncer cuando existe.As it is currently known, applied to the " screening " methods, it is a low cost test but also of low sensitivity (in the best series it reaches 51-59%), that is, it has a huge amount of false negatives, or what is the same, very low ability to detect cancer when it exists.
Los problemas del método actual son una baja sensibilidad y el difícil acceso a la población general, debido a la incomodidad que esta prueba tenga que realizarse en un centro médico y por parte de un especialista.The problems of the current method are a low sensitivity and difficult access to the general population, due to the discomfort that this test has to be done in a center doctor and by a specialist.
En una revisión hecha en el New England (revista especializada médica), del número de noviembre de 2005, se especifica el hecho de que existe aproximadamente un 40% de la población femenina que no acuda a las campañas de detección precoz del cáncer, teniendo como causas el tener que pedir una cita previa y principalmente por pudor.In a review made in the New England (specialized medical journal), dated November 2005, is specifies the fact that there is approximately 40% of the female population that does not attend early detection campaigns of cancer, having as causes to have to make an appointment and mainly for modesty.
El cáncer de cérvix tiene una incidencia en países desarrollados de entre un 4 hasta un 8 por 100.000 mujeres, no así en los países menos desarrollados, que alcanza hasta un 16 a 20 por 100.000 mujeres.Cervical cancer has an incidence in developed countries between 4 and 8 per 100,000 women, not so in less developed countries, which reaches up to 16 to 20 per 100,000 women.
Ante tal problema de salud, se plantearon campañas de detección precoz para disminuir la mortalidad producida por dicho tipo de cáncer, detectando y tratando las lesiones precursoras.Faced with such a health problem, they raised early detection campaigns to reduce the mortality produced for this type of cancer, detecting and treating the lesions precursors
Actualmente, la prueba que se emplea es la citología que realiza el ginecóloga observando con visión directa el cuello uterino y recogiendo, con un escobillón y una espátula, una muestra del endocervix y otra del extocervix respectivamente, frotándolas contra un porta de vidrio, visualizándose después al microscopio, utilizando la llamada tinción de papanicolau.Currently, the test used is the cytology performed by the gynecologist observing with direct vision the cervix and collecting, with a swab and a spatula, a sample of the endocervix and another of the extocervix respectively, rubbing them against a glass holder, then visualizing the microscope, using the so-called pap smear.
Este método ha resultado muy útil para disminuir la mortalidad, teniendo en cuenta el coste-eficacia. El único problema es la baja sensibilidad que ofrece dicha prueba, ya que tiene una sensibilidad de 51-59%, lo que significa que tiene muchos falsos negativos.This method has been very useful for decrease mortality, taking into account the cost-effectiveness The only problem is the low sensitivity offered by this test, since it has a sensitivity 51-59%, which means you have a lot of fakes negative
Para corregir este defecto, se trabajó con nuevas técnicas, como la llamada citología en medio líquido, haciendo que aumentase dicha sensibilidad.To correct this defect, we worked with new techniques, such as the so-called liquid cytology, causing that sensitivity to increase.
Otro descubrimiento crucial fue el hallazgo de la asociación causal en el 99,9% de cánceres del virus del papiloma humano o VPH; aunque no es asumible la detección del virus como método de screening, debido a la alta prevalencia de este virus en mujeres de entre 20 y 30 años.Another crucial discovery was the finding of the causal association in 99.9% of papillomavirus cancers human or HPV; although virus detection is not acceptable as screening method, due to the high prevalence of this virus in women between 20 and 30 years old.
La citología en medio líquido ha supuesto una gran mejora, ya que, aunque la toma la sigue realizando el ginecólogo, la extensión de la muestra se realiza en un recipiente con un medio líquido, consiguiendo que la muestra sea de mejor calidad, disminuyendo la cantidad de falsos negativos de forma notable, al igual que así se permite realizar la llamada prueba del VPH, que como ya se ha mencionado, es el agente causal en el 99,9% de los cánceres.Cytology in liquid medium has meant a great improvement, since, although the shot is still made by the gynecologist, sample extension is performed in a container with a liquid medium, getting the sample to be better quality, decreasing the amount of false negatives in a way remarkable, as well as allowing the so-called test of the HPV, which as already mentioned, is the causative agent in 99.9% of cancers.
Cabe destacar que se ha trabajado en mayor o menor medida, por parte de muchos especialistas, para procurar los progresos de la ciencia en este último siglo, en el campo del cáncer cervical.It should be noted that it has worked in greater or lesser extent, by many specialists, to procure the progress of science in this last century, in the field of cervical cancer.
Al trabajo pionero de Schauta y Werthein, sobre el tratamiento quirúrgico, siguieron las aportaciones de Hinselman y Papanicolau, que sentaron las bases de la prevención secundaria del cáncer, mediante la detección, diagnóstico y tratamiento de las lesiones pre-invasivas o micro-invasivas.To the pioneering work of Schauta and Werthein, about the surgical treatment, followed Hinselman's contributions and Pap smear, which laid the foundations for secondary prevention of cancer, through the detection, diagnosis and treatment of pre-invasive lesions or micro-invasive
Sin embargo, a pesar de los programas de cribado, se siguen diagnosticando cánceres de cuello uterino en estadio avanzado.However, despite the programs of screening, cervical cancers are still diagnosed in advanced stage
El descubrimiento de la asociación del papilomavirus y su confirmación en la etiología por Zur Handerson ha supuesto un gran cambio en la estrategia diagnóstica.The discovery of the association of papillomavirus and its confirmation in etiology by Zur Handerson It has meant a great change in the diagnostic strategy.
Visto lo anterior, se deduce, que la mejor manera de prevenir el tipo de cáncer que aquí concierne, sería que todas las mujeres en edad de riesgo, pudieran someterse regularmente a controles ginecológicos, y dado que ello está lejos de la realidad, el objeto de la presente invención consiste, precisamente, en acercar esta posibilidad al mayor número posible de mujeres en todo el mundo, independientemente de su situación económica, o geográfica, mediante la creación del dispositivo aplicable a la realización de autotest para detección de lesiones precursoras de cáncer de cuello uterino y procedimiento para el mismo que preconiza, del cual, cabe mencionar, por otra parte, que el peticionario desconoce la existencia de cualquier otro que presente unas características técnicas, estructurales y constitutivas semejantes, y cuyo objetivo, tal como se ha mencionado, consiste en solventar la problemática anteriormente descrita que presentan los sistemas conocidos actualmente para el mismo fin.Given the above, it follows, that the best way to prevent the type of cancer that concerns here, would be that all women of risk age could undergo regularly to gynecological controls, and since that is far of reality, the object of the present invention consists, precisely, in bringing this possibility as close as possible of women around the world, regardless of their situation economic, or geographical, by creating the device applicable to performing self-test for injury detection cervical cancer precursors and procedure for same that advocates, of which, it is worth mentioning, on the other hand, that the petitioner is unaware of the existence of any other who present technical, structural and constitutive similar, and whose objective, as it has been mentioned, is to solve the problem above described that presently known systems present for the same end.
Así, el dispositivo aplicable a la realización de autotest para detección de lesiones precursoras de cáncer de cuello uterino que la invención propone, constituye por sí solo una evidente novedad dentro de su campo de aplicación, ya que a tenor de su utilización se consigue de forma taxativa un medio práctico y sobretodo eficaz para procurar el control ginecológico a un número de mujeres considerablemente mucho más amplio.Thus, the device applicable to the realization of self-test for detection of cancer precursor lesions of cervix that the invention proposes, constitutes by itself a evident novelty within its field of application, since under of its use a practical means is achieved in a taxative way and especially effective to provide gynecological control to a number of women considerably much wider.
De forma concreta, el dispositivo se configura como un "set" o caja, en cuyo interior incorpora un frasco y un cepillo que a su vez se encuentra alojado en una vaina exterior.Specifically, the device is configured as a "set" or box, inside which incorporates a jar and a brush that in turn is housed in a pod Exterior.
Dicho cepillo, será utilizado por la mujer que, a modo de tampón vaginal, se lo introducirá haciéndolo rotar como un lápiz de labios, empujando así un émbolo con el extremo de forma semiesférica, que en el fondo de la vagina, permite la recogida de células que serán utilizadas para el estudio citológico, así como para la detección de ADN del virus del papiloma humano.Said brush will be used by the woman who, as a vaginal tampon, it will be introduced by rotating it as a lipstick, thus pushing a plunger with the shape end hemispherical, which at the bottom of the vagina, allows the collection of cells that will be used for cytological study, as well as for the detection of human papillomavirus DNA.
Al extraerse el descrito elemento de la vagina, se aplicará su extremo distal en el interior de un frasco con una solución de metanol, depositándose en él la recogida celular.When the described element of the vagina is removed, its distal end will be applied inside a jar with a methanol solution, depositing cell collection in it.
El frasco será posteriormente remitido a un laboratorio de referencia, donde se realizará la lectura de dicha muestra (siendo dicha lectura ventajosamente realizada con el sistema de citología en medio líquido, que ha resultado ser mucho más eficaz que la citología convencional), recibiendo la usuaria el resultado, a partir del cual deberá realizar, o no, ulteriores controles o visitas a especialistas para someterse a tratamiento, en función de los resultados obtenidos.The bottle will then be sent to a reference laboratory, where the reading of said laboratory will be carried out sample (said reading being advantageously performed with the cytology system in liquid medium, which has turned out to be a lot more effective than conventional cytology), receiving the user the result, from which you must carry out, or not, further controls or visits to specialists to undergo treatment, depending on the results obtained.
Así pues, la invención presenta notables ventajas tanto para las mujeres en particular como para el sistema sanitario en general, ya que con dicho sistema, se puede conseguir por una parte que un mayor número de mujeres se sometan a control citológico regular, pues resulta un método cómodo, y económico que además no resta tiempo a la usuaria para acudir a la consulta, con la consecuente pérdida de horas de trabajo que por ejemplo le puede acarrear, y por otra parte, se puede evitar la saturación de consultas médicas con fines preventivos por esta causa, ya que únicamente acudirán a las consultas aquellas mujeres con patología.Thus, the invention presents remarkable advantages for both women in particular and for the system sanitary in general, since with this system, you can get on the one hand that a greater number of women are put under control Regular cytological, as it is a convenient, and economical method that In addition there is no time left for the user to attend the consultation, with the consequent loss of working hours that for example can carry, and on the other hand, saturation of medical consultations for preventive purposes for this cause, since Only those women with pathology.
El nuevo dispositivo aplicable a la realización de autotest para detección de lesiones precursoras de cáncer de cuello uterino representa, por consiguiente, una estructura innovadora de características estructurales y constitutivas desconocidas hasta ahora para tal fin, razones que unidas a su utilidad práctica, la dotan de fundamento suficiente para obtener el privilegio de exclusividad que se solicita.The new device applicable to the realization of self-test for detection of cancer precursor lesions of cervix therefore represents a structure Innovative structural and constitutive features unknown so far for that purpose, reasons that together with its practical utility, provide it with sufficient foundation to obtain the privilege of exclusivity that is requested.
Para complementar la descripción que se está realizando y con objeto de ayudar a una mejor comprensión de las características de la invención, se acompaña a la presente memoria descriptiva, como parte integrante de la misma, de un juego de planos, en los que con carácter ilustrativo y no limitativo se ha representado lo siguiente:To complement the description that is being performing and in order to help a better understanding of the characteristics of the invention, is attached herein descriptive, as an integral part of it, of a game of planes, in which with an illustrative and non-limiting nature, represented the following:
La figura número 1.- Muestra una vista en planta de un ejemplo de realización del dispositivo objeto de la invención, en la que se aprecian los principales elementos que comprende así como la configuración de los mismos.Figure number 1.- Shows a view in plan of an embodiment of the device object of the invention, in which the main elements that It also includes their configuration.
La figura número 2.- Muestra una vista en alzado lateral del ejemplo del dispositivo representado en la figura anterior.Figure number 2.- Shows a view in side elevation of the example of the device represented in the previous figure.
La figura número 3.- Muestra una vista en detalle del extremo del cepillo.Figure number 3.- Shows a view in Brush end detail.
A la vista de las mencionadas figuras y de acuerdo con la numeración adoptada, se puede observar en ellas un ejemplo de realización preferente del dispositivo aplicable a la realización de autotest para detección de lesiones precursoras de cáncer de cuello uterino, el cual comprende las partes y pasos que se indican y describen a continuación.In view of the aforementioned figures and of according to the numbering adopted, you can see in them a preferred embodiment of the device applicable to the self-test for the detection of precursor lesions of cervical cancer, which includes the parts and steps that They are indicated and described below.
Así, tal como se aprecia en dichas figuras, el dispositivo en cuestión está constituido esencialmente a partir de una caja o envase (1) en cuyo interior se alojan, adecuadamente dispuestas para permitir su correcto traslado y almacenamiento, así como su posterior envío, una vez utilizado, a un laboratorio en condiciones seguras, un frasco de metanol (2) y un cepillo (3), el cual se encuentra introducido en una vaina exterior (4) por la que se desliza a modo de émbolo, disponiendo el cepillo (3) en su extremo distal de una cabeza (5) compuesta por un conjunto de cerdas dispuestas en forma semiesférica, y existiendo así mismo, en la parte central de la vaina exterior (4) un ensanchamiento circular (6).Thus, as can be seen in these figures, the device in question is essentially constituted from a box or container (1) inside which they are housed, properly arranged to allow proper transport and storage, as well as its subsequent shipment, once used, to a laboratory in safe conditions, a bottle of methanol (2) and a brush (3), the which is inserted in an outer sheath (4) by which it slides like a piston, arranging the brush (3) in its distal end of a head (5) composed of a set of bristles arranged in hemispherical form, and existing likewise, in the central part of the outer sheath (4) a widening circular (6).
Por su parte, el procedimiento a seguir para la realización del autotest con el dispositivo de la invención, consiste en que el descrito cepillo (3), será utilizado por la mujer que, a modo de tampón vaginal, se lo introducirá haciéndolo rotar en el interior del cuello uterino, empujando, mediante la sujeción de la vaina externa (4) por el ensanchamiento (6) el émbolo con la cabeza de forma semiesférica (5), que en el fondo de la vagina, se impregnará de células uterinas.For its part, the procedure to follow for the realization of self-test with the device of the invention, it consists in that the described brush (3), will be used by the woman who, as a vaginal tampon, will introduce it by doing so rotate inside the cervix, pushing, using the clamping of the outer sheath (4) by widening (6) the piston with the hemispherical head (5), which at the bottom of The vagina will be impregnated with uterine cells.
Al extraerse el cepillo (3) de la vagina, se aplicará su extremo distal o cabeza (5) en el interior del frasco (2) con la solución de metanol, depositándose en él la recogida celular.When the brush (3) is removed from the vagina, apply its distal end or head (5) inside the bottle (2) with the methanol solution, the collection being deposited in it mobile.
El frasco será posteriormente remitido a un laboratorio de referencia, donde se realizará la lectura de dicha muestra (siendo dicha lectura ventajosamente realizada con el sistema de citología en medio líquido, que ha resultado ser mucho más eficaz que la citología convencional), recibiendo la usuaria el resultado, a partir del cual se procederá en consecuencia.The bottle will then be sent to a reference laboratory, where the reading of said laboratory will be carried out sample (said reading being advantageously performed with the cytology system in liquid medium, which has turned out to be a lot more effective than conventional cytology), receiving the user the result, from which it will proceed accordingly.
Descrita suficientemente la naturaleza de la invención, así como la manera de ponerla en práctica, no se considera necesario hacer más amplia su explicación para que cualquier experto en la materia comprenda su alcance y las ventajas que de ella se derivan, haciendo constar que, dentro de su esencialidad, podrá ser llevada a la práctica en otras formas de realización que difieran en detalle de la indicada a título de ejemplo, y a las cuales alcanzará igualmente la protección que se recaba siempre que no se altere, cambie o modifique su principio fundamental.Describe sufficiently the nature of the invention, as well as how to put it into practice, is not considers it necessary to broaden his explanation so that any subject matter expert understands its scope and advantages that derive from it, stating that, within its essentiality, may be implemented in other forms of embodiment that differ in detail from that indicated by way of example, and which will also achieve the protection that collects as long as it does not alter, change or modify its principle fundamental.
Claims (1)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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ES200602056A ES2296527B1 (en) | 2006-07-28 | 2006-07-28 | DEVICE APPLICABLE TO THE REALIZATION OF AUTOTEST FOR DETECTION OF PRECURSOR INJURIES OF CANCER OF UTERINE NECK. |
PCT/ES2007/070134 WO2008012393A1 (en) | 2006-07-28 | 2007-07-17 | Medical kit and set of instruments for performing a home test for the detection of precursor lesions of cervical cancer |
BRPI0713816-4A BRPI0713816A2 (en) | 2006-07-28 | 2007-07-17 | medical kit for performing a self-test for the detection of cervical cancer precursor lesions and a toolkit for performing a self-test for the detection of cervical cancer precursor lesions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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ES200602056A ES2296527B1 (en) | 2006-07-28 | 2006-07-28 | DEVICE APPLICABLE TO THE REALIZATION OF AUTOTEST FOR DETECTION OF PRECURSOR INJURIES OF CANCER OF UTERINE NECK. |
Publications (2)
Publication Number | Publication Date |
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ES2296527A1 true ES2296527A1 (en) | 2008-04-16 |
ES2296527B1 ES2296527B1 (en) | 2009-03-16 |
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Application Number | Title | Priority Date | Filing Date |
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ES200602056A Expired - Fee Related ES2296527B1 (en) | 2006-07-28 | 2006-07-28 | DEVICE APPLICABLE TO THE REALIZATION OF AUTOTEST FOR DETECTION OF PRECURSOR INJURIES OF CANCER OF UTERINE NECK. |
Country Status (3)
Country | Link |
---|---|
BR (1) | BRPI0713816A2 (en) |
ES (1) | ES2296527B1 (en) |
WO (1) | WO2008012393A1 (en) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3815580A (en) * | 1972-08-31 | 1974-06-11 | C Oster | Apparatus for and method of collecting and preserving cytologic samples |
GB1394925A (en) * | 1972-06-09 | 1975-05-21 | Cabral V R | Sampling of human secretions |
US5449071A (en) * | 1993-10-28 | 1995-09-12 | Levy; Abner | Tray for medical specimen collection kit |
US5787891A (en) * | 1995-03-16 | 1998-08-04 | Sak; Robert | Method and apparatus for sampling cervical tissue |
US6346086B1 (en) * | 1998-04-23 | 2002-02-12 | Cook Urological Inc. | Endocervical and exocervical cell collection device |
US20020161313A1 (en) * | 2000-02-24 | 2002-10-31 | Sak Robert F. | Method and apparatus for sampling cervical tissue |
WO2003011144A1 (en) * | 2001-07-31 | 2003-02-13 | Private Concepts, Inc. | Intra-vaginal self-administered cell collecting device and method |
ES2187553T3 (en) * | 1993-05-11 | 2003-06-16 | Gynetech Inc | CERVICAL FABRIC SAMPLING DEVICE. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6343086B1 (en) * | 1996-09-09 | 2002-01-29 | Natural Microsystems Corporation | Global packet-switched computer network telephony server |
-
2006
- 2006-07-28 ES ES200602056A patent/ES2296527B1/en not_active Expired - Fee Related
-
2007
- 2007-07-17 BR BRPI0713816-4A patent/BRPI0713816A2/en not_active Application Discontinuation
- 2007-07-17 WO PCT/ES2007/070134 patent/WO2008012393A1/en active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1394925A (en) * | 1972-06-09 | 1975-05-21 | Cabral V R | Sampling of human secretions |
US3815580A (en) * | 1972-08-31 | 1974-06-11 | C Oster | Apparatus for and method of collecting and preserving cytologic samples |
ES2187553T3 (en) * | 1993-05-11 | 2003-06-16 | Gynetech Inc | CERVICAL FABRIC SAMPLING DEVICE. |
US5449071A (en) * | 1993-10-28 | 1995-09-12 | Levy; Abner | Tray for medical specimen collection kit |
US5787891A (en) * | 1995-03-16 | 1998-08-04 | Sak; Robert | Method and apparatus for sampling cervical tissue |
US6346086B1 (en) * | 1998-04-23 | 2002-02-12 | Cook Urological Inc. | Endocervical and exocervical cell collection device |
US20020161313A1 (en) * | 2000-02-24 | 2002-10-31 | Sak Robert F. | Method and apparatus for sampling cervical tissue |
WO2003011144A1 (en) * | 2001-07-31 | 2003-02-13 | Private Concepts, Inc. | Intra-vaginal self-administered cell collecting device and method |
Also Published As
Publication number | Publication date |
---|---|
BRPI0713816A2 (en) | 2012-11-06 |
ES2296527B1 (en) | 2009-03-16 |
WO2008012393A1 (en) | 2008-01-31 |
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