ES2294941B1 - PROCEDURE FOR OBTAINING HUMAN BEAR IMPLANTS IN BIOCOMPATIBLE MATERIALS. - Google Patents

PROCEDURE FOR OBTAINING HUMAN BEAR IMPLANTS IN BIOCOMPATIBLE MATERIALS. Download PDF

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Publication number
ES2294941B1
ES2294941B1 ES200602364A ES200602364A ES2294941B1 ES 2294941 B1 ES2294941 B1 ES 2294941B1 ES 200602364 A ES200602364 A ES 200602364A ES 200602364 A ES200602364 A ES 200602364A ES 2294941 B1 ES2294941 B1 ES 2294941B1
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Prior art keywords
interest
prototype
area
patient
virtual
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Expired - Fee Related
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ES200602364A
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Spanish (es)
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ES2294941A1 (en
Inventor
David Cano Sanz
Francisco Javie Garcia Gomez
Marina De La Fuente Gomez
Alfredo Sanchez Bustos
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Trisermedin S L
TRISERMEDIN SL
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Trisermedin S L
TRISERMEDIN SL
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Priority to ES200602364A priority Critical patent/ES2294941B1/en
Priority to PCT/ES2007/000522 priority patent/WO2008034924A1/en
Publication of ES2294941A1 publication Critical patent/ES2294941A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G09B23/30—Anatomical models
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2875—Skull or cranium
    • A61F2002/2889—Maxillary, premaxillary or molar implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds

Abstract

Procedimiento para obtener implantes óseos humanos en materiales biocompatibles; caracterizado porque comprende las etapas de: Obtener imágenes médicas de la zona interés del paciente. Procesar las imágenes obtenidas informáticamente hasta conseguir una reconstrucción virtual de la zona interés del paciente. Obtener un prototipo físico del implante utilizando técnicas de prototipado rápido en cooperación con la reconstrucción virtual de la zona de interés. Obtener el implante físico por moldeo a partir de un molde obtenido sobre el prototipo.Procedure to obtain bone implants humans in biocompatible materials; characterized in that it comprises  the stages of: Obtain medical images of the area of interest of the patient. Process the images obtained by computer until get a virtual reconstruction of the area of interest of patient. Obtain a physical prototype of the implant using rapid prototyping techniques in cooperation with reconstruction virtual area of interest. Get the physical implant by molding from a mold obtained on the prototype.

Description

Procedimiento para obtener implantes óseos humanos en materiales biocompatibles.Procedure to obtain bone implants humans in biocompatible materials.

Objeto de la invenciónObject of the invention

La presente invención se refiere a un procedimiento para obtener implantes óseos humanos en materiales biocompatibles.The present invention relates to a procedure to obtain human bone implants in materials biocompatible

Antecedentes de la invenciónBackground of the invention

En la actualidad, dentro del campo de la colocación de implantes, se emplean diversas técnicas:Currently, within the field of implant placement, various techniques are used:

Por ejemplo, en el caso de ciertas prótesis maxilofaciales, la morfología de los implantes se intenta conseguir mediante el modelado del material biocompatible antes de su polimerización. Esto ocasiona en la mayoría de los casos resultados estéticos lejos del objetivo buscado.For example, in the case of certain prostheses maxillofacials, implant morphology is attempted by modeling the biocompatible material before its polymerization. This causes in most cases results Aesthetics far from the objective sought.

Otro de los procedimientos utilizados consiste en la preselección de implantes fabricados, cuyo tamaño se aproxime al requerido (prótesis de cadera, rodilla, malares, etc.). En este caso tampoco se consiguen los requerimientos estéticos buscados.Another of the procedures used consists of in the pre-selection of manufactured implants, whose size is Approximate the required (hip, knee, malar prostheses, etc.). In this case the aesthetic requirements are not achieved Wanted.

Cuando la zona a reconstruir es muy amplia, se suelen utilizar porciones de huesos procedentes por ejemplo de la tibia. Como se puede inferir, este tipo de intervenciones somete al paciente a nuevos riesgos.When the area to rebuild is very wide, it they usually use portions of bones coming for example from the tibia. As can be inferred, this type of intervention subjects the Patient to new risks.

Todos estos inconvenientes se subsanan con la utilización del procedimiento de la invención.All these inconveniences are corrected with the use of the method of the invention.

Descripción de la invenciónDescription of the invention

El procedimiento de la invención sirve una manera óptima para fabricar implantes óseos humanos personalizados en materiales biocompatibles, ya que no sería necesario fabricarlos o seleccionarlos durante la operación. El tiempo, y por tanto los costes, así como el riesgo de la intervención se reducen considerablemente. Además la invención contempla igualmente la fabricación de un modelo de la zona de interés del paciente, además de la propia prótesis o implante, de forma que el médico puede planificar y entrenar la operación con antelación. Esto coopera en reducir aún más el tiempo y costes de la intervención, mejorar los resultados estéticos y facilitar la recuperación. Además, otra ventaja asociada a la invención es que, debido la posibilidad de poder planificar y entrenar la intervención con antelación, se pueden detectar y corregir errores no detectados previamente, y que durante la intervención tiene una solución más comprometida.The process of the invention serves a Optimal way to manufacture custom human bone implants in biocompatible materials, since it would not be necessary to manufacture them or select them during the operation. The weather, and therefore the costs, as well as the risk of intervention are reduced considerably. Furthermore, the invention also contemplates the manufacture of a model of the area of interest of the patient, in addition  of the prosthesis itself or implant, so that the doctor can Plan and train the operation in advance. This cooperates in further reduce the time and costs of the intervention, improve aesthetic results and facilitate recovery. In addition, another advantage associated with the invention is that, due to the possibility of be able to plan and train the intervention in advance, it they can detect and correct errors not previously detected, and that During the intervention you have a more compromised solution.

De acuerdo con la invención, el procedimiento comprenden las siguientes etapas:According to the invention, the procedure They comprise the following stages:

- Obtener imágenes médicas de la zona de interés del paciente. Esta etapa se lleva a cabo mediante diversas técnicas médicas conocidas o que puedan ser desarrolladas en el futuro, y típicamente mediante la realización de una tomografía axial computerizada y/o resonancia magnética.- Obtain medical images of the area of interest of the patient. This stage is carried out by various known medical techniques or that can be developed in the future, and typically by performing a tomography computerized axial and / or magnetic resonance.

- Procesado mediante ordenador de las imágenes obtenidas hasta conseguir una reconstrucción virtual de la zona interés del paciente.- Computer processing of images obtained until a virtual reconstruction of the area is achieved patient interest

- Obtención de un diseño o prototipo del implante. Esta etapa puede materializarse principalmente de dos formas: o bien mediante el diseño virtual del prototipo sobre la reconstrucción virtual de la zona de interés, y su posterior modelado físico mediante técnicas de prototipado rápido; o bien mediante el modelado físico mediante técnicas de prototipado rápido de la zona interés del cliente, y el modelado manual sobre ésta reproducción de la zona de interés del prototipo. También pueden combinarse estas dos formas de trabajar.- Obtaining a design or prototype of the implant. This stage can materialize mainly from two forms: either through the virtual design of the prototype on the virtual reconstruction of the area of interest, and its subsequent physical modeling by rapid prototyping techniques; O well through physical modeling using rapid prototyping techniques of the client's area of interest, and manual modeling on it Reproduction of the area of interest of the prototype. They can also combine these two ways of working.

En algunos casos este modelado manual se realiza con materiales que son deformables o flexibles, y que por lo tanto a la hora de confeccionar el molde definitivo para el implante su deformación podría originar imprecisiones o imperfecciones. En estos casos la invención contempla la toma de imágenes mediante tomografía axial computerizada del modelo obtenido manualmente en material deformable y/o flexible y el procesado mediante ordenador de las imágenes obtenidas, análogamente a como se ha descrito en etapas anteriores, para obtener un diseño virtual del implante, y a partir de éste su modelado por técnicas de prototipado rápido en materiales de consistencia adecuada para resistir la fabricación del molde.In some cases this manual modeling is done  with materials that are deformable or flexible, and therefore when making the final mold for the implant your deformation could cause inaccuracies or imperfections. In these cases the invention contemplates the taking of images by computerized axial tomography of the model obtained manually in deformable and / or flexible material and computer processing of the images obtained, analogously as described in previous stages, to obtain a virtual implant design, and to from this its modeling by rapid prototyping techniques in materials of adequate consistency to resist manufacturing of the mold.

En cualquier caso, la invención también contempla el modelado por técnicas de prototipado rápido de la zona de interés del paciente para entrenar la operación o comprobar el buen ajuste del implante obtenido por los procedimientos anteriormente mencionados, directamente por reconstrucción virtual y prototipado rápido.In any case, the invention also includes modeling by rapid prototyping techniques in the area of interest of the patient to train the operation or check the good adjustment of the implant obtained by the procedures previously mentioned, directly by virtual reconstruction and rapid prototyping.

- Obtención del implante físico a partir del prototipo obtenido según la etapa anterior, realizando un molde sobre éste, y generando en el molde la prótesis o implante definitivo.- Obtaining the physical implant from prototype obtained according to the previous stage, making a mold on it, and generating in the mold the prosthesis or implant definitive.

- Esterilización de la prótesis o implante conseguido.- Sterilization of the prosthesis or implant got.

Descripción de una realización práctica de la invenciónDescription of a practical embodiment of the invention

El procedimiento de la invención comprenden las siguientes etapas:The process of the invention comprises the following stages:

1. Obtener una imagen médica de la zona de interés del paciente, en la cual se localiza el defecto que hay que subsanar mediante el implante resultado final del procedimiento de la invención. Estas imágenes se pueden obtener por cualquiera de las técnicas conocidas o que se puedan desarrollar en el futuro, y típicamente mediante tomografía axial computerizada o resonancia magnética.1. Obtain a medical image of the area of patient interest, in which the defect is located that must be remedy through the implant the final result of the procedure the invention. These images can be obtained by any of the techniques known or that may be developed in the future, and typically by computerized tomography or resonance magnetic

2. Procesar las imágenes obtenidas mediante computadora hasta obtener una reconstrucción virtual de la zona interés del paciente.2. Process the images obtained by computer until you get a virtual reconstruction of the area patient interest

3. Obtener un prototipo del implante. Esta etapa se puede materializar de dos formas:3. Obtain a prototype of the implant. This stage It can be materialized in two ways:

- Mediante el diseño virtual del implante utilizando técnicas informáticas, según las cuales por ejemplo se puede obtener el diseño de una parte ósea desaparecida como réplica especular de su simétrica en la propia anatomía del paciente. A partir del diseño virtual, y mediante técnicas de prototipado rápido con la participación de maquinaria adecuada, se obtiene el prototipo físico.- Through virtual implant design using computer techniques, according to which for example you can get the design of a missing bone part as a replica mirror your symmetric in the patient's own anatomy. TO starting from virtual design, and using prototyping techniques fast with the participation of suitable machinery, you get the physical prototype

- En casos complejos, mediante la fabricación por prototipado rápido de una reproducción de la zona de interés del paciente, ya que está capturada en el ordenador, y la fabricación manual sobre ésta de un modelo de la prótesis, que si se realiza en materiales consistentes podría constituirse en el prototipo definitivo. No obstante lo cual, y dado que este modelo manual muchas veces se realiza en materiales deformables no susceptibles de mantener su forma en la fabricación del molde, en estos casos es necesario realizar una tomografía axial computerizada de este modelo consiguiendo su captura virtual, y a partir de esta captura obtener el prototipo definitivo en materiales de consistencia adecuada utilizando técnicas de prototipado rápido.- In complex cases, by manufacturing by rapid prototyping of a reproduction of the area of interest of the patient, since it is captured on the computer, and the manual manufacturing of this model of the prosthesis, which if It is made of consistent materials could become the definitive prototype However, and given that this model manual is often performed on deformable materials not likely to maintain its shape in the manufacture of the mold, in these cases it is necessary to perform a computerized axial tomography of this model getting its virtual capture, and from this capture get the definitive prototype in materials from adequate consistency using prototyping techniques Quick.

4. Obtener el implante físico, realizando en primer lugar un molde de colada a partir del prototipo, y después moldeando el implante definitivo.4. Obtain the physical implant, performing in first a casting mold from the prototype, and then molding the definitive implant.

5. Esterilizar el implante obtenido, con lo cual estará preparado para su implantación en el paciente.5. Sterilize the implant obtained, thereby  will be prepared for implantation in the patient.

Descrita suficientemente la naturaleza de la invención, así como la manera de realizarse en la práctica, debe hacerse constar que las disposiciones anteriormente indicadas son susceptibles de modificaciones de detalle en cuanto no alteren el principio fundamental.Describe sufficiently the nature of the invention, as well as how to perform it in practice, should be noted that the provisions indicated above are susceptible to detail modifications as soon as they do not alter the fundamental principle.

Claims (6)

1. Procedimiento para obtener implantes óseos humanos en materiales biocompatibles; caracterizado porque comprende las etapas de:1. Procedure to obtain human bone implants in biocompatible materials; characterized in that it comprises the stages of: - Obtener imágenes médicas de la zona interés del paciente.- Obtain medical images of the area of interest of the patient. - Procesar las imágenes obtenidas informáticamente hasta conseguir una reconstrucción virtual de la zona interés del paciente.- Process the images obtained informatically until a virtual reconstruction of the patient interest zone. - Obtener un prototipo físico del implante utilizando técnicas de prototipado rápido en cooperación con la reconstrucción virtual de la zona de interés.- Obtain a physical prototype of the implant using rapid prototyping techniques in cooperation with the Virtual reconstruction of the area of interest. - Obtener el implante físico por moldeo a partir de un molde obtenido sobre el prototipo.- Obtain the physical implant by molding from of a mold obtained on the prototype. - Esterilizar el implante obtenido.- Sterilize the implant obtained. 2. Procedimiento según reivindicación 1 caracterizado porque la obtención de imágenes médicas se realiza preferentemente por tomografía axial computerizada y/o resonancia magnética.2. Method according to claim 1 characterized in that the medical imaging is preferably performed by computerized axial tomography and / or magnetic resonance imaging. 3. Procedimiento según reivindicación 1 caracterizado porque la obtención del prototipo físico se realiza mediante su modelado virtual directamente en la reconstrucción virtual de la zona de interés del paciente, y su materialización por técnicas de prototipado rápido.3. Method according to claim 1 characterized in that the obtaining of the physical prototype is carried out by means of its virtual modeling directly in the virtual reconstruction of the area of interest of the patient, and its materialization by rapid prototyping techniques. 4. Procedimiento según reivindicación 1 caracterizado porque en casos complejos la obtención del prototipo se realiza mediante su modelado manual sobre una reproducción de la zona de interés del paciente obtenida por técnicas de prototipado rápido.4. Method according to claim 1 characterized in that in complex cases the obtaining of the prototype is carried out by means of its manual modeling on a reproduction of the area of interest of the patient obtained by rapid prototyping techniques. 5. Procedimiento según reivindicación 4 caracterizado porque en casos donde el modelado manual sobre la reproducción de la zona interés se realice en materiales deformables durante la fabricación del molde, se realiza una tomografía axial computarizada de dicho modelado para obtener una captura virtual del mismo, y a partir de la misma la obtención del prototipo en materiales de consistencia adecuada utilizando técnicas de prototipado rápido.5. Method according to claim 4 characterized in that in cases where manual modeling on the reproduction of the area of interest is performed on deformable materials during the manufacture of the mold, a computerized axial tomography of said modeling is performed to obtain a virtual capture thereof, and From it, obtaining the prototype in materials of adequate consistency using rapid prototyping techniques. 6. Procedimiento según reivindicación 3 caracterizado porque en el modelado virtual del prototipo para implantes destinados a reparar zonas óseas desaparecidas se replica especularmente la parte simétrica de la anatomía del paciente.6. Method according to claim 3 characterized in that in the virtual modeling of the prototype for implants intended to repair missing bone areas, the symmetrical part of the patient's anatomy is replicated specularly.
ES200602364A 2006-09-18 2006-09-18 PROCEDURE FOR OBTAINING HUMAN BEAR IMPLANTS IN BIOCOMPATIBLE MATERIALS. Expired - Fee Related ES2294941B1 (en)

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ES200602364A ES2294941B1 (en) 2006-09-18 2006-09-18 PROCEDURE FOR OBTAINING HUMAN BEAR IMPLANTS IN BIOCOMPATIBLE MATERIALS.
PCT/ES2007/000522 WO2008034924A1 (en) 2006-09-18 2007-09-18 Method for obtaining human osseous implants in biocompatible materials

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ES200602364A ES2294941B1 (en) 2006-09-18 2006-09-18 PROCEDURE FOR OBTAINING HUMAN BEAR IMPLANTS IN BIOCOMPATIBLE MATERIALS.

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ES2294941B1 true ES2294941B1 (en) 2009-09-28

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