ES2231007B2 - CREAM FOR THE TREATMENT OF PSORIASIS. - Google Patents

Abstract

Cream for the treatment of psoriasis, comprising: hydrophilic ointment, urea, salicylic acid, tardoak, gentamicin sulfate acetonide triamcinolone, ammonium lactate, diethanolamine of coconut acids (cocamide), said hydrophilic ointment consisting of: lanette-N wax, petrolatum filament, sodium lauryl sulfate, propylene glycol, distilled water, nipagin cs. The method for making the cream is also claimed. Application in the manufacture of a cream against psoriasis.

Description

Cream for the treatment of psoriasis.

The technical sector of this invention is the of the creams and formulas that have as purpose the application dermatological for the elimination of symptoms and manifestations of the said disease.

Indication of the prior art. Psoriasis is considered a disease that, due to its characteristics, is more annoying than serious, since only the pustular and erythrodermic varieties of the patient are considered serious
piss

This disease is related to the response Immune and 1 inflammation. New cells of normal skin it takes about 1 month to migrate from the most layers deep from the skin to the surface; in psoriasis, this process only takes a few days, so that there is a constant replacement of cells, dead cells cannot slowly peel and they persist forming large scales.

It manifests through plates that appear on certain parts of the body which can spread, grow older, and reduce according to circumstances not clearly known, and among which the toxins influence, and therefore it is relevant state of nervousness of the patient, the characteristics of your food intake, alcohol consumption, and other factors such as room temperature, sunstroke and even of the quality of the air breathed or the proper functioning of the Airways of the individual. Medication can also influence to Cure other diseases. You have genetic family disease of hereditary type and it seems that the immune system of Each person is decisive for its appearance.

Psoriasis has been treated primarily by two systems. One of them, by ingesting orally administered drugs (etretinate, methotrexate, cyclosporine), are aggressive drugs with significant side effects and should therefore be used only in very important psoriasis and under strict control.
doctor.

Another is the treatment based on creams, ointments and hair lotions with different active ingredients (calcipotriol, corticosteroids, ditranol, salicylic acid). Is the most widely used and indicated treatment form that the affectation is less than 35% of the body surface.

A third system complementary to any of the Previous is phototherapy. It usually has side effects to long term.

The usual treatment applied by doctors includes options for anti-psoriatic treatments, including local agents (steroids, tar, anthraline and calcipotriol), phototherapy (UVB, PUVA), and systemic treatments (methotrexate, cyclosporine and etretinate). A combination of treatment modalities is often necessary to achieve clinical success. Unfortunately, phototherapy modalities can be laborious and uncomfortable. Systemic treatments have important adverse effects. A preparation containing zinc pyrithione (0.25%) is also used in a vehicle with isopropyl myristate to treat certain cases of
psoriasis.

The present invention aims at a cream for the treatment of psoriasis that is based on a set of active ingredients arranged in an excipient and which together they reach to produce beneficial effects for the patient, until the Total disappearance of disease symptoms.

This formula consists of:

ointment hydrophilic 51.8% urea 15.0% acid salicylic 5.0% tardoak 6.0% gentamicin sulfate 0.1% triamcinolone acetonide 0.1% lactate ammonium 12.0% acid diethanolamine coconut fatty (cocamide) 10.0% 100.0%

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The hydrophilic ointment is composed of:

wax lanette-N 25.0% vaseline upright 25.0% lauryl sulfate sodium  \; 1.0% propylene glycol 12.0% distilled water 36.9% nipagin cs  \; 0.1% 100.0%

These amounts may suffer small variations based on specific needs, based on the specific need to combat disease symptoms to Certain varieties of it.

An embodiment has been clearly indicated.

The elaboration of said cream takes place through a method for which it is required:

- beakers

- rod

- mortar - pistil

- means to submit to a water bath.

Form of preparation

1) In a beaker (A) the Fat phase components, consisting of:

- wax lanette-n

- petroleum jelly

- tardoak

- coconut fatty acid dietanol amine (cocamida)

In another beaker (B) the Water phase components, consisting of:

- sodium lauryl sulfate

- propylene glycol

- distilled water

- nipagin

urea

Both glasses are taken to the water bath until the fat phase content (vessel A) has passed into the form liquid

2) The vessels are removed from the water bath, and in the glass B - still hot - the gentamicin is incorporated until its dissolution.

3) Subsequently B is poured over A and stir with rod until homogenization and take body.

4) Ammonium lactate is added until complete homogenization

5) In a mortar the salicylic acid and Triamcinolone It is emulsified with a little propylene glycol and it is incorporate the previous mixture. Remove until homogenized completely.

6) Packaged in jar protected from light.

It is susceptible of industrial application, in the manufacture of a cream against psoriasis.

Claims (2)

1. Cream for the treatment of psoriasis characterized in that it comprises: ointment hydrophilic 51.8% urea 15.0% acid salicylic  \; 5.0% tardoak  \; 6.0% gentamicin sulfate  \; 0.1% acetonide triamcinolone  \; 0.1% lactate ammonium 12.0% Acid diethanolamine coconut (cocamida) 10.0% Said hydrophilic ointment formed by: wax lanette-N 25.0% vaseline upright 25.0% lauryl sulfate sodium  \; 1.0% propylene glycol 12.0% Water distilled 36.9% nipagin cs  \; 0.1% 2. Method for making cream for the treatment of psoriasis, according to the formula set forth in claim 1 characterized in that it comprises the following phases: 1) In a beaker (A) the Fat phase components, consisting of: - wax lanette-N - petroleum jelly - tardoak - coconut fatty acid dietanol amine (cocamida) In another beaker (B) the Water phase components, consisting of: - sodium lauryl sulfate - propylene glycol - distilled water - nipagin urea Both glasses are taken to the water bath until the fat phase content (vessel A) has passed into the form liquid 2) The vessels are removed from the water bath, and in the glass B - still hot - the gentamicin is incorporated until its dissolution. 3) Subsequently B is poured over A and stir with rod until homogenization and take body. 4) Ammonium lactate is added until complete homogenization 5) In a mortar the salicylic acid and Triamcinolone It is emulsified with a little propylene glycol and it is incorporate the previous mixture. Remove until homogenized completely. 6) Packaged in jar protected from light.