ES2200706B1 - DERIVATIVES OF 4-4'-BIPIRIDIL-2-2'-BISOXAZOLES AND 4-4'-BIPIRIDIL-2-2'-BISTIAZOLES AS ANTINEOPLASICAL AGENTS. - Google Patents

DERIVATIVES OF 4-4'-BIPIRIDIL-2-2'-BISOXAZOLES AND 4-4'-BIPIRIDIL-2-2'-BISTIAZOLES AS ANTINEOPLASICAL AGENTS.

Info

Publication number
ES2200706B1
ES2200706B1 ES200201938A ES200201938A ES2200706B1 ES 2200706 B1 ES2200706 B1 ES 2200706B1 ES 200201938 A ES200201938 A ES 200201938A ES 200201938 A ES200201938 A ES 200201938A ES 2200706 B1 ES2200706 B1 ES 2200706B1
Authority
ES
Spain
Prior art keywords
bipiridil
bistiazoles
bisoxazoles
derivatives
bipyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200201938A
Other languages
Spanish (es)
Other versions
ES2200706A1 (en
Inventor
Yolanda Martin Sanchez Cantalejo
Maria Jesus Villa Hormaeche
Beatriz Saez Pizarro
Javier Soto Romero
Miguel Fernandez Braña
Juan Carlos Lacal Sanjuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Europea de Madrid SA
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Europea de Madrid SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad Europea de Madrid SA filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES200201938A priority Critical patent/ES2200706B1/en
Priority to PCT/ES2003/000424 priority patent/WO2004016622A1/en
Priority to AU2003260515A priority patent/AU2003260515A1/en
Publication of ES2200706A1 publication Critical patent/ES2200706A1/en
Application granted granted Critical
Publication of ES2200706B1 publication Critical patent/ES2200706B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de 4-4''-Bipiridil-2-2''-bisoxazoles y 4-4''-bipiridil-2- 2''-bistiazoles como agentes antineoplásicos. La presente invención presenta nuevos derivados de 4-4''-bipiridil-2-2''- bisoxazoles y 4-4''-bipiridil-2-2''-bistiazoles de fórmula general I con actividad antiproliferativa, y concretamente, de células malignas como HT-29. Por otro lado, se indica en la presente patente el mecanismo de su producción industrial y su uso para el desarrollo de compuestos a farmacéuticos para el tratamiento de tumores humanos.Derivatives of 4-4 '' - Bipyridyl-2-2 '' - bisoxazoles and 4-4 '' - bipyridyl-2- 2 '' - bistiazoles as antineoplastic agents. The present invention presents new derivatives of 4-4 '' - bipyridyl-2-2 '' - bisoxazoles and 4-4 '' - bipyridyl-2-2 '' - bistiazoles of general formula I with antiproliferative activity, and specifically, of malignant cells like HT-29. On the other hand, the mechanism of its industrial production and its use for the development of compounds to pharmacists for the treatment of human tumors is indicated in the present patent.

ES200201938A 2002-08-16 2002-08-16 DERIVATIVES OF 4-4'-BIPIRIDIL-2-2'-BISOXAZOLES AND 4-4'-BIPIRIDIL-2-2'-BISTIAZOLES AS ANTINEOPLASICAL AGENTS. Expired - Fee Related ES2200706B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200201938A ES2200706B1 (en) 2002-08-16 2002-08-16 DERIVATIVES OF 4-4'-BIPIRIDIL-2-2'-BISOXAZOLES AND 4-4'-BIPIRIDIL-2-2'-BISTIAZOLES AS ANTINEOPLASICAL AGENTS.
PCT/ES2003/000424 WO2004016622A1 (en) 2002-08-16 2003-08-14 Derivatives of 4-4'-bipyridyl-2-2'-bisoxazoles and 4-4'-bipyridyl-2-2'-bistiazoles as antineoplasic agents
AU2003260515A AU2003260515A1 (en) 2002-08-16 2003-08-14 Derivatives of 4-4'-bipyridyl-2-2'-bisoxazoles and 4-4'-bipyridyl-2-2'-bistiazoles as antineoplasic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200201938A ES2200706B1 (en) 2002-08-16 2002-08-16 DERIVATIVES OF 4-4'-BIPIRIDIL-2-2'-BISOXAZOLES AND 4-4'-BIPIRIDIL-2-2'-BISTIAZOLES AS ANTINEOPLASICAL AGENTS.

Publications (2)

Publication Number Publication Date
ES2200706A1 ES2200706A1 (en) 2004-03-01
ES2200706B1 true ES2200706B1 (en) 2005-06-01

Family

ID=31725576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200201938A Expired - Fee Related ES2200706B1 (en) 2002-08-16 2002-08-16 DERIVATIVES OF 4-4'-BIPIRIDIL-2-2'-BISOXAZOLES AND 4-4'-BIPIRIDIL-2-2'-BISTIAZOLES AS ANTINEOPLASICAL AGENTS.

Country Status (3)

Country Link
AU (1) AU2003260515A1 (en)
ES (1) ES2200706B1 (en)
WO (1) WO2004016622A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2344780B1 (en) * 2009-03-03 2011-07-22 Universidad De Barcelona USEFUL BISTIAZOLIC COMPOUNDS FOR THE TREATMENT OF CANCER.
ES2543918T3 (en) 2010-09-02 2015-08-25 Universitat De Barcelona Fluorinated thiazoles useful for cancer treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3148194A (en) * 1961-07-03 1964-09-08 Arapahoe Chemicals Inc Certain 1, 4-bis[2(4-substituted, 5-phenyloxazolyl)] benzenes
FR2066252A5 (en) * 1970-10-20 1971-08-06 Sumitomo Chemical Co Oxazolyl optical brighteners for textiles and plastics
DD260698A1 (en) * 1986-11-27 1988-10-05 Tech Hochschule C Schorlemmer METHOD FOR THE PRODUCTION OF BIS-OXAZOLIUM SALTS
JP2000318313A (en) * 1999-05-07 2000-11-21 Mitsui Chemicals Inc Optical recording medium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RICE, C. et al.: New multidentate ligands for supramolecular coordination chemistry: double and triple helical complexes of ligands containing pyridil and thiazol donor units. J. Chem. Society, Dalton Transactions, 2001, Vol. 5, páginas 550-559. Página 551, conjunto L3. *

Also Published As

Publication number Publication date
AU2003260515A1 (en) 2004-03-03
AU2003260515A8 (en) 2004-03-03
ES2200706A1 (en) 2004-03-01
WO2004016622A1 (en) 2004-02-26

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