ES2200622B1 - ANALYTICAL METHOD FOR THE DIAGNOSIS OF AIDS AND USE OF RELATED MONOCLONAL ANTIBODIES. - Google Patents
ANALYTICAL METHOD FOR THE DIAGNOSIS OF AIDS AND USE OF RELATED MONOCLONAL ANTIBODIES.Info
- Publication number
- ES2200622B1 ES2200622B1 ES200100333A ES200100333A ES2200622B1 ES 2200622 B1 ES2200622 B1 ES 2200622B1 ES 200100333 A ES200100333 A ES 200100333A ES 200100333 A ES200100333 A ES 200100333A ES 2200622 B1 ES2200622 B1 ES 2200622B1
- Authority
- ES
- Spain
- Prior art keywords
- aids
- diagnosis
- monoclonal antibodies
- analytical method
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Método analítico para el diagnóstico del sida y uso de anticuerpos monoclonales relacionados. Dicho método analítico está basado en el diferente nivel de expresión de la molécula de antígeno HLA-G que tiene lugar en la superficie de los monocitos y linfocitos de la sangre periférica de individuos sanos e individuos infectados con HIV-1, y comprende la evaluación mediante citometría de flujo del porcentaje de dichos monocitos y/o linfocitos que expresan dicha molécula de antígeno HLA-G en el individuo objeto de análisis. Además, el uso de anticuerpos monoclonales específicos contra la molécula de HLA-G para sensibilizar dichos monocitos y/o linfocitos de los pacientes de SIDA, frente a las células citotóxicas del sistema inmune. Aplicación en el diagnóstico y tratamiento del SIDA.Analytical method for the diagnosis of AIDS and the use of related monoclonal antibodies. Said analytical method is based on the different level of expression of the HLA-G antigen molecule that takes place on the surface of the monocytes and lymphocytes of the peripheral blood of healthy individuals and individuals infected with HIV-1, and comprises evaluation by Flow cytometry of the percentage of said monocytes and / or lymphocytes expressing said HLA-G antigen molecule in the individual under analysis. In addition, the use of specific monoclonal antibodies against the HLA-G molecule to sensitize said monocytes and / or lymphocytes of AIDS patients, against the cytotoxic cells of the immune system. Application in the diagnosis and treatment of AIDS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100333A ES2200622B1 (en) | 2001-02-14 | 2001-02-14 | ANALYTICAL METHOD FOR THE DIAGNOSIS OF AIDS AND USE OF RELATED MONOCLONAL ANTIBODIES. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100333A ES2200622B1 (en) | 2001-02-14 | 2001-02-14 | ANALYTICAL METHOD FOR THE DIAGNOSIS OF AIDS AND USE OF RELATED MONOCLONAL ANTIBODIES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2200622A1 ES2200622A1 (en) | 2004-03-01 |
ES2200622B1 true ES2200622B1 (en) | 2005-05-16 |
Family
ID=31970569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100333A Expired - Fee Related ES2200622B1 (en) | 2001-02-14 | 2001-02-14 | ANALYTICAL METHOD FOR THE DIAGNOSIS OF AIDS AND USE OF RELATED MONOCLONAL ANTIBODIES. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2200622B1 (en) |
-
2001
- 2001-02-14 ES ES200100333A patent/ES2200622B1/en not_active Expired - Fee Related
Non-Patent Citations (4)
Title |
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BLASCHITZ A. et al. Comparative patterns of monoclonal antibodies to HLA-G in human tissues and on cell lines: a comparative study. Human Immunology, 2000, 61, páginas 1074-1085. * |
MOREAU P. et al. IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes. International Immunology, 1999, Vol. 11, nº 5, páginas 803-811. \\ X 8-10 * |
ONNO M. et al. Modulation of HLA-g antigens expression by Human Cytomegalovirus: Specific induction in activated macrophagues harboring Human Cytomegalovirus infection. J. Immunol., 2000, 164: 6426-6434. \\ X 8-10 * |
PUPPO F. et al. Increased level of seum HLA Class I Antigens in HIV infection. Human Immunology, 1994, 40, 259-266. * |
Also Published As
Publication number | Publication date |
---|---|
ES2200622A1 (en) | 2004-03-01 |
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