ES2198203B1 - NEW ANALYTICAL METHODS BASED ON THE EXPRESSION OF CERTAIN NK CELL RECEPTORS IN CD8 T-CELLS. - Google Patents

NEW ANALYTICAL METHODS BASED ON THE EXPRESSION OF CERTAIN NK CELL RECEPTORS IN CD8 T-CELLS.

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Publication number
ES2198203B1
ES2198203B1 ES200200447A ES200200447A ES2198203B1 ES 2198203 B1 ES2198203 B1 ES 2198203B1 ES 200200447 A ES200200447 A ES 200200447A ES 200200447 A ES200200447 A ES 200200447A ES 2198203 B1 ES2198203 B1 ES 2198203B1
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ES
Spain
Prior art keywords
expression
cells
certain
cell receptors
analytical methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200200447A
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Spanish (es)
Other versions
ES2198203A1 (en
Inventor
Rafael Solana Lara
Jose Peña Martinez
Raquel Tarazona Lafarga
Maria Dolores Galiani Ramos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Cordoba
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Universidad de Cordoba
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Publication date
Application filed by Universidad de Cordoba filed Critical Universidad de Cordoba
Priority to ES200200447A priority Critical patent/ES2198203B1/en
Publication of ES2198203A1 publication Critical patent/ES2198203A1/en
Application granted granted Critical
Publication of ES2198203B1 publication Critical patent/ES2198203B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Nuevos métodos analíticos basados en la expresión de determinados receptores de células NK en células T CD8. Dichos métodos analíticos se basan esencialmente en la medida del nivel de expresión de determinados receptores de células NK en células T CD8 mediante técnicas de inmunofluorescencia y citometría de flujo. Estos métodos tienen importantes aplicaciones en medicina para la detección, seguimiento y evolución de enfermedades con repercusiones inmunológicas, especialmente SIDA.New analytical methods based on the expression of certain NK cell receptors in CD8 T cells. Such analytical methods are essentially based on the measurement of the level of expression of certain NK cell receptors in CD8 T cells by immunofluorescence techniques and flow cytometry. These methods have important applications in medicine for the detection, monitoring and evolution of diseases with immunological repercussions, especially AIDS.

ES200200447A 2002-02-25 2002-02-25 NEW ANALYTICAL METHODS BASED ON THE EXPRESSION OF CERTAIN NK CELL RECEPTORS IN CD8 T-CELLS. Expired - Fee Related ES2198203B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200200447A ES2198203B1 (en) 2002-02-25 2002-02-25 NEW ANALYTICAL METHODS BASED ON THE EXPRESSION OF CERTAIN NK CELL RECEPTORS IN CD8 T-CELLS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200200447A ES2198203B1 (en) 2002-02-25 2002-02-25 NEW ANALYTICAL METHODS BASED ON THE EXPRESSION OF CERTAIN NK CELL RECEPTORS IN CD8 T-CELLS.

Publications (2)

Publication Number Publication Date
ES2198203A1 ES2198203A1 (en) 2004-01-16
ES2198203B1 true ES2198203B1 (en) 2005-04-01

Family

ID=30470530

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200200447A Expired - Fee Related ES2198203B1 (en) 2002-02-25 2002-02-25 NEW ANALYTICAL METHODS BASED ON THE EXPRESSION OF CERTAIN NK CELL RECEPTORS IN CD8 T-CELLS.

Country Status (1)

Country Link
ES (1) ES2198203B1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006459A (en) * 1986-03-31 1991-04-09 T Cell Sciences, Inc. Therapeutic and diagnostic methods using soluble T cell surface molecules
ES2051651B1 (en) * 1992-12-10 1995-01-01 Univ Salamanca PROCEDURE FOR THE SIMULTANEOUS QUANTIFICATION, IN A SINGLE MEASUREMENT, OF THE MAIN TYPES OF HUMAN LYMPHOCYTES AND THEIR SUB-POPULATIONS.
JPH11271304A (en) * 1998-03-24 1999-10-08 Jcr Pharmaceuticals Co Ltd Hiv infection diagnosing method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AHMAD et al. Modulation of expression of the MHC class I-binding natural killer cell receptors, and NK activity in relation to viral load in HIV-infected/AIDS patients. J. Med. Virol. Noviembre 2001, Vol. 65, Nº 3, páginas 431-40. *
LUCIA B. et al. Evidence of a selective depletion of a CD16+, CD56+, CD8+ natural killer cell subset during HIV infection. Cytometry. Marzo 1995, Vol. 22, Nº 1, páginas 10-15. *
TARAZONA et al. NK-associated receptors on CD8 T cells from treatment-naive HIV-infected individuals: defective expression of CD56. AIDS. Enero 2002, Vol. 16, Nº 2, páginas 197-200. *

Also Published As

Publication number Publication date
ES2198203A1 (en) 2004-01-16

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