ES2197817A1 - Method of obtaining a buffered hypertonic solution and solution thus obtained - Google Patents
Method of obtaining a buffered hypertonic solution and solution thus obtainedInfo
- Publication number
- ES2197817A1 ES2197817A1 ES200201324A ES200201324A ES2197817A1 ES 2197817 A1 ES2197817 A1 ES 2197817A1 ES 200201324 A ES200201324 A ES 200201324A ES 200201324 A ES200201324 A ES 200201324A ES 2197817 A1 ES2197817 A1 ES 2197817A1
- Authority
- ES
- Spain
- Prior art keywords
- solution
- obtaining
- buffered
- buffered hypertonic
- hypertonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000243 solution Substances 0.000 title abstract 5
- 239000000819 hypertonic solution Substances 0.000 title abstract 2
- 229940021223 hypertonic solution Drugs 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000001488 sodium phosphate Substances 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 229910000397 disodium phosphate Inorganic materials 0.000 abstract 1
- 235000019800 disodium phosphate Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 abstract 1
- 235000019799 monosodium phosphate Nutrition 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/30—Alkali metal phosphates
- C01B25/301—Preparation from liquid orthophosphoric acid or from an acid solution or suspension of orthophosphates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a method of obtaining a buffered hypertonic solution and the solution thus obtained, said solution being of the type of saline solutions with a constant pH which can be used in therapeutics. The inventive method consists in adding phosphoric acid (3) and sodium hydroxide (4) to deionised water (2) in a reactor (1), simultaneously but at different speeds, thereby producing an aqueous solution of disodium phosphate and monosodium phosphate in a proportion of 1:2 in said solution.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200201324A ES2197817B2 (en) | 2002-06-10 | 2002-06-10 | PROCEDURE FOR OBTAINING A STAMPED HYPERTONIC SOLUTION AND OBTAINED SOLUTION. |
| PCT/ES2003/000280 WO2003104146A1 (en) | 2002-06-10 | 2003-06-10 | Method of obtaining a buffered hypertonic solution and solution thus obtained |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200201324A ES2197817B2 (en) | 2002-06-10 | 2002-06-10 | PROCEDURE FOR OBTAINING A STAMPED HYPERTONIC SOLUTION AND OBTAINED SOLUTION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2197817A1 true ES2197817A1 (en) | 2004-01-01 |
| ES2197817B2 ES2197817B2 (en) | 2004-12-16 |
Family
ID=29724721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200201324A Expired - Fee Related ES2197817B2 (en) | 2002-06-10 | 2002-06-10 | PROCEDURE FOR OBTAINING A STAMPED HYPERTONIC SOLUTION AND OBTAINED SOLUTION. |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2197817B2 (en) |
| WO (1) | WO2003104146A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES404975A1 (en) * | 1972-07-19 | 1975-07-01 | Roncales Sa | Procedure for the obtaining of a taped hypertonic solution. (Machine-translation by Google Translate, not legally binding) |
| ES8504625A2 (en) * | 1972-07-19 | 1985-05-16 | Fisons Iberica S A | Buffered hypertonic soln. |
| WO1985004552A1 (en) * | 1984-04-10 | 1985-10-24 | Baxter Travenol Laboratories, Inc. | Solutions of mitomycin |
-
2002
- 2002-06-10 ES ES200201324A patent/ES2197817B2/en not_active Expired - Fee Related
-
2003
- 2003-06-10 WO PCT/ES2003/000280 patent/WO2003104146A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES404975A1 (en) * | 1972-07-19 | 1975-07-01 | Roncales Sa | Procedure for the obtaining of a taped hypertonic solution. (Machine-translation by Google Translate, not legally binding) |
| ES8504625A2 (en) * | 1972-07-19 | 1985-05-16 | Fisons Iberica S A | Buffered hypertonic soln. |
| WO1985004552A1 (en) * | 1984-04-10 | 1985-10-24 | Baxter Travenol Laboratories, Inc. | Solutions of mitomycin |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2197817B2 (en) | 2004-12-16 |
| WO2003104146A1 (en) | 2003-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20040101 Kind code of ref document: A1 |
|
| FG2A | Definitive protection |
Ref document number: 2197817B2 Country of ref document: ES |
|
| GC2A | Exploitation certificate registered application with search report |
Effective date: 20060627 |
|
| PC2A | Transfer of patent |
Owner name: CASEN RECORDATI,S.L. Effective date: 20150803 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20220629 |