ES2195200T3 - Construccion de peptidos de rama multiples. - Google Patents
Construccion de peptidos de rama multiples.Info
- Publication number
- ES2195200T3 ES2195200T3 ES97953934T ES97953934T ES2195200T3 ES 2195200 T3 ES2195200 T3 ES 2195200T3 ES 97953934 T ES97953934 T ES 97953934T ES 97953934 T ES97953934 T ES 97953934T ES 2195200 T3 ES2195200 T3 ES 2195200T3
- Authority
- ES
- Spain
- Prior art keywords
- cellular
- peptides
- hiv
- fusion
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNAS CONSTRUCCIONES DE PEPTIDOS DE RAMIFICACIONES MULTIPLES, FORMADAS A PARTIR DE PEPTIDOS DERIVADOS DE LA GLICOPROTEINA DE TRANSMEMBRANA QUE FORMAN UNA ENVOLTURA GP41 DEL VIH E INCLUYEN LA SECUENCIA DE CONSENSO RQGY, PRECEDIDA DE 0 A 4 RESIDUOS DE ACIDOS AMINADOS, Y SEGUIDA DE 2 A 4 RESIDUOS DE ACIDOS AMINADOS, PREFERENTEMENTE, RQGYSPL. ESTAS CONSTRUCCIONES MUESTRAN UNA AFINIDAD DE RECEPTOR INCREMENTADA E IMPIDEN LA FUSION DE UNA CELULA A OTRA. EJERCEN UN EFECTO VIROSTATICO DIRECTO. POR EL HECHO DE QUE PRESENTAN LA MISMA FRECUENCIA DE PEPTIDOS VARIAS VECES, ESTOS MBPCS PUEDEN NEUTRALIZAR IN VITRO LAS DIFERENTES ETAPAS DE FUSION DE ENVOLTURA VIRAL/MEMBRANA CELULAR, Y DE FUSION DE MEMBRANA CELULAR INFECTADA/MEMBRANA CELULAR NO INFECTADA DE VARIAS CEPAS DE VIH -1 Y VIH - 2. ESTOS RESULTADOS PERMITEN UN USO POTENCIAL EN EL TRATAMIENTO DE LA INFECCION POR VIH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9627114.3A GB9627114D0 (en) | 1996-12-31 | 1996-12-31 | Multiple branch peptide constructions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195200T3 true ES2195200T3 (es) | 2003-12-01 |
Family
ID=10805139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97953934T Expired - Lifetime ES2195200T3 (es) | 1996-12-31 | 1997-12-30 | Construccion de peptidos de rama multiples. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6379679B1 (es) |
EP (1) | EP0950063B1 (es) |
AP (1) | AP9901615A0 (es) |
AT (1) | ATE235511T1 (es) |
AU (1) | AU5764898A (es) |
CA (1) | CA2274853C (es) |
DE (1) | DE69720266T2 (es) |
DK (1) | DK0950063T3 (es) |
ES (1) | ES2195200T3 (es) |
GB (1) | GB9627114D0 (es) |
PT (1) | PT950063E (es) |
WO (1) | WO1998029443A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9727424D0 (en) * | 1997-12-31 | 1998-02-25 | Armel Sa | Liposomes containing multiple branch peptide constructions for use against human immunodeficiency virus |
US7285621B2 (en) * | 1999-06-29 | 2007-10-23 | Ambrilia Biopharma | Multiple branch peptide construction |
WO2004092724A2 (en) * | 2003-04-11 | 2004-10-28 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health | Multiple antigenic peptide assay for detection of hiv or siv type retroviruses |
US20060229433A1 (en) * | 2003-05-20 | 2006-10-12 | Cellpep Sa | Modified antiviral peptides with increased activity and cell membrane affinity |
WO2008094222A2 (en) * | 2006-10-06 | 2008-08-07 | Trustees Of Princeton | Porphyrin catalysts and methods of use thereof |
AU2017259821A1 (en) | 2016-05-04 | 2018-12-13 | Abilita Bio, Inc. | Methods and platform for preparing multispanning membrane proteins |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229490A (en) * | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
WO1993003766A1 (en) * | 1991-08-13 | 1993-03-04 | Repligen Corporation | Multiple antigen peptides for use as hiv vaccines |
US5556744A (en) * | 1992-05-29 | 1996-09-17 | The Trustees Of The University Of Pennsylvania | Methods and compositions for diagnosing and treating certain HIV infected patients |
IL110929A0 (en) * | 1993-09-13 | 1994-11-28 | Armel Sa | Multiple branch peptide constructions and pharmaceutical compositions containing them |
-
1996
- 1996-12-31 GB GBGB9627114.3A patent/GB9627114D0/en active Pending
-
1997
- 1997-12-30 CA CA002274853A patent/CA2274853C/en not_active Expired - Fee Related
- 1997-12-30 DK DK97953934T patent/DK0950063T3/da active
- 1997-12-30 DE DE69720266T patent/DE69720266T2/de not_active Expired - Fee Related
- 1997-12-30 PT PT97953934T patent/PT950063E/pt unknown
- 1997-12-30 AT AT97953934T patent/ATE235511T1/de not_active IP Right Cessation
- 1997-12-30 AU AU57648/98A patent/AU5764898A/en not_active Abandoned
- 1997-12-30 AP APAP/P/1999/001615A patent/AP9901615A0/en unknown
- 1997-12-30 EP EP97953934A patent/EP0950063B1/en not_active Expired - Lifetime
- 1997-12-30 WO PCT/EP1997/007334 patent/WO1998029443A1/en active IP Right Grant
- 1997-12-30 ES ES97953934T patent/ES2195200T3/es not_active Expired - Lifetime
-
1999
- 1999-06-29 US US09/342,847 patent/US6379679B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0950063T3 (da) | 2003-06-23 |
US6379679B1 (en) | 2002-04-30 |
WO1998029443A1 (en) | 1998-07-09 |
CA2274853C (en) | 2007-05-29 |
AU5764898A (en) | 1998-07-31 |
AP9901615A0 (en) | 1999-09-30 |
EP0950063B1 (en) | 2003-03-26 |
GB9627114D0 (en) | 1997-02-19 |
ATE235511T1 (de) | 2003-04-15 |
EP0950063A1 (en) | 1999-10-20 |
DE69720266T2 (de) | 2003-12-04 |
DE69720266D1 (de) | 2003-04-30 |
PT950063E (pt) | 2003-07-31 |
CA2274853A1 (en) | 1998-07-09 |
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