ES2193601T3 - Utilizacion de peptidos de citrulina derivados a la filagrina en el marco del tratamiento de enfermedades autoinmunes. - Google Patents
Utilizacion de peptidos de citrulina derivados a la filagrina en el marco del tratamiento de enfermedades autoinmunes.Info
- Publication number
- ES2193601T3 ES2193601T3 ES98964537T ES98964537T ES2193601T3 ES 2193601 T3 ES2193601 T3 ES 2193601T3 ES 98964537 T ES98964537 T ES 98964537T ES 98964537 T ES98964537 T ES 98964537T ES 2193601 T3 ES2193601 T3 ES 2193601T3
- Authority
- ES
- Spain
- Prior art keywords
- filagrine
- citruline
- framework
- treatment
- autoimmune diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 102100028314 Filaggrin Human genes 0.000 abstract 1
- 101710088660 Filaggrin Proteins 0.000 abstract 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229960002173 citrulline Drugs 0.000 abstract 1
- 235000013477 citrulline Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Rehabilitation Therapy (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Utilización de un antígeno peptídico reconocido específicamente por los autoanticuerpos antifilagrina presentes en el suero de pacientes que padecen poliartritis reumatoide, constituido por un péptido que comprende la unidad tripeptídica Ser-Cit-His, en la que Cit representa un residuo de citrulina, el cual se deriva de toda o de parte de la secuencia de una unidad de filagrina por sustitución de la menos un residuo de arginina por un residuo de citrulina, para la obtención de un medicamento destinado al tratamiento de una patología que implica una respuesta autoinmune respecto de epitopes de citrulina reconocidos por dichos anticuerpos antifilagrina, con la excepción de la utilización de un péptido de secuencia: Gln Gly Ser Cit His Gln Gln Ala Arg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9716672A FR2773078B1 (fr) | 1997-12-30 | 1997-12-30 | Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2193601T3 true ES2193601T3 (es) | 2003-11-01 |
Family
ID=9515271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98964537T Expired - Lifetime ES2193601T3 (es) | 1997-12-30 | 1998-12-29 | Utilizacion de peptidos de citrulina derivados a la filagrina en el marco del tratamiento de enfermedades autoinmunes. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1041997B1 (es) |
| JP (1) | JP4557421B2 (es) |
| AT (1) | ATE237345T1 (es) |
| AU (1) | AU1971899A (es) |
| CA (1) | CA2315294C (es) |
| DE (1) | DE69813620T2 (es) |
| DK (1) | DK1041997T3 (es) |
| ES (1) | ES2193601T3 (es) |
| FR (1) | FR2773078B1 (es) |
| WO (1) | WO1999034819A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2900657B1 (fr) | 2006-05-03 | 2009-04-17 | Univ Toulouse | Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide |
| FR2908134B1 (fr) * | 2007-12-04 | 2012-10-12 | Univ Toulouse 3 Paul Sabatier | Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3307636B2 (ja) * | 1990-01-31 | 2002-07-24 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ オクラホマ | 自己免疫疾患のためのアッセイおよび治療 |
| JP4162259B2 (ja) * | 1991-04-26 | 2008-10-08 | ビオメリュー・ソシエテ・アノニム | リウマチ性関節炎抗体により認識される抗原、抗原製剤及びその適用方法 |
| WO1994017411A1 (en) * | 1993-01-27 | 1994-08-04 | Duke University | Methods and agents for the diagnosis and treatment of rheumatoid arthritis |
| FR2752842B1 (fr) * | 1996-08-30 | 1998-11-06 | Biomerieux Sa | Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide |
| NL1004539C2 (nl) * | 1996-11-15 | 1998-05-20 | Stichting Tech Wetenschapp | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
| AU2155899A (en) * | 1997-11-28 | 1999-06-16 | Innogenetics N.V. | Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment |
| FR2773157B1 (fr) * | 1997-12-30 | 2001-10-05 | Bio Merieux | Epitopes peptidiques reconnus par des auto-anticorps antifilaggrine presents dans le serum des patients atteints de polyarthrite rhumatoide |
-
1997
- 1997-12-30 FR FR9716672A patent/FR2773078B1/fr not_active Expired - Fee Related
-
1998
- 1998-12-29 DE DE69813620T patent/DE69813620T2/de not_active Expired - Lifetime
- 1998-12-29 WO PCT/FR1998/002900 patent/WO1999034819A2/fr active IP Right Grant
- 1998-12-29 AU AU19718/99A patent/AU1971899A/en not_active Abandoned
- 1998-12-29 ES ES98964537T patent/ES2193601T3/es not_active Expired - Lifetime
- 1998-12-29 JP JP2000527267A patent/JP4557421B2/ja not_active Expired - Fee Related
- 1998-12-29 DK DK98964537T patent/DK1041997T3/da active
- 1998-12-29 EP EP98964537A patent/EP1041997B1/fr not_active Expired - Lifetime
- 1998-12-29 CA CA2315294A patent/CA2315294C/fr not_active Expired - Fee Related
- 1998-12-29 AT AT98964537T patent/ATE237345T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2315294C (fr) | 2012-07-03 |
| JP2002500195A (ja) | 2002-01-08 |
| EP1041997A2 (fr) | 2000-10-11 |
| FR2773078A1 (fr) | 1999-07-02 |
| DE69813620D1 (de) | 2003-05-22 |
| WO1999034819A3 (fr) | 1999-11-04 |
| DE69813620T2 (de) | 2004-02-12 |
| JP4557421B2 (ja) | 2010-10-06 |
| AU1971899A (en) | 1999-07-26 |
| WO1999034819A2 (fr) | 1999-07-15 |
| DK1041997T3 (da) | 2003-08-04 |
| EP1041997B1 (fr) | 2003-04-16 |
| ATE237345T1 (de) | 2003-05-15 |
| FR2773078B1 (fr) | 2000-05-26 |
| CA2315294A1 (fr) | 1999-07-15 |
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