ES2190311A1 - Gene for fructose hereditary intolerance therapy consists of a promoter linked to fructoquinase cDNA - Google Patents
Gene for fructose hereditary intolerance therapy consists of a promoter linked to fructoquinase cDNAInfo
- Publication number
- ES2190311A1 ES2190311A1 ES200002221A ES200002221A ES2190311A1 ES 2190311 A1 ES2190311 A1 ES 2190311A1 ES 200002221 A ES200002221 A ES 200002221A ES 200002221 A ES200002221 A ES 200002221A ES 2190311 A1 ES2190311 A1 ES 2190311A1
- Authority
- ES
- Spain
- Prior art keywords
- gene
- fructose
- hereditary
- fructoquinase
- intolerance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 229930091371 Fructose Natural products 0.000 title abstract 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 title abstract 4
- 239000005715 Fructose Substances 0.000 title abstract 4
- 239000002299 complementary DNA Substances 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 102000003793 Fructokinases Human genes 0.000 abstract 2
- 108090000156 Fructokinases Proteins 0.000 abstract 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 206010072104 Fructose intolerance Diseases 0.000 abstract 1
- 206010019878 Hereditary fructose intolerance Diseases 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Chimaeric gene for the development of a therapeutic approach to hereditary fructose intolerance. It consists of a promoter tied to the gene or the DNAc of fructokinase. The chimaeric gene is inserted in a liver cell, allowing the fructokinase to act. It also refers to a transgenic animal whose genome includes this chimaeric gene, with the animal developing disorders associated with hereditary intolerance to fructose after fructose, sorbitol or saccharose has been administered.< IMAGE >The gene for fructose hereditary intolerance therapy comprises a promoter linked to the gene or the cDNA of fructoquinase. It is inserted in a hepatic cell to permit expression of fructoquinase.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002221A ES2190311B1 (en) | 2000-08-31 | 2000-08-31 | CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002221A ES2190311B1 (en) | 2000-08-31 | 2000-08-31 | CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2190311A1 true ES2190311A1 (en) | 2003-07-16 |
ES2190311B1 ES2190311B1 (en) | 2004-06-16 |
Family
ID=27589265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002221A Expired - Lifetime ES2190311B1 (en) | 2000-08-31 | 2000-08-31 | CHEMICAL GENE FOR THE DEVELOPMENT OF THERAPEUTIC APPROXIMATIONS TO HEREDITARY INTOLERANCE TO FRUCTOSE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2190311B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5075229A (en) * | 1987-06-16 | 1991-12-24 | Ohio University Edison Animal Biotechnology Center | Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase |
WO1995025169A1 (en) * | 1994-03-14 | 1995-09-21 | Universitat Autonoma De Barcelona | CHIMERIC GENE USING THE GENE OR cDNA OF INSULINE, SPECIALLY FOR THE GENE THERAPY OF DIABETES |
-
2000
- 2000-08-31 ES ES200002221A patent/ES2190311B1/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5075229A (en) * | 1987-06-16 | 1991-12-24 | Ohio University Edison Animal Biotechnology Center | Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase |
WO1995025169A1 (en) * | 1994-03-14 | 1995-09-21 | Universitat Autonoma De Barcelona | CHIMERIC GENE USING THE GENE OR cDNA OF INSULINE, SPECIALLY FOR THE GENE THERAPY OF DIABETES |
Non-Patent Citations (1)
Title |
---|
HAYWARD B.E. et al: 'Structure and alternative splicing of the ketohexokinase gene', Eur. J. Biochem., Octubre 1998, Vol. 257, No. 1, paginas 85-91 * |
Also Published As
Publication number | Publication date |
---|---|
ES2190311B1 (en) | 2004-06-16 |
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