ES2180893T3 - BENZOTIOPHENES, COMPOSITIONS THAT CONTAIN THEM AND PROCEDURES. - Google Patents

BENZOTIOPHENES, COMPOSITIONS THAT CONTAIN THEM AND PROCEDURES.

Info

Publication number
ES2180893T3
ES2180893T3 ES97303090T ES97303090T ES2180893T3 ES 2180893 T3 ES2180893 T3 ES 2180893T3 ES 97303090 T ES97303090 T ES 97303090T ES 97303090 T ES97303090 T ES 97303090T ES 2180893 T3 ES2180893 T3 ES 2180893T3
Authority
ES
Spain
Prior art keywords
sub
sup
benzotiophenes
procedures
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97303090T
Other languages
Spanish (es)
Inventor
Michael Paul Clay
Charles Alan Frolik
Charles David Jones
Terry Donald Lindstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2180893T3 publication Critical patent/ES2180893T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

ESTA INVENCION PROPORCIONA COMPUESTOS DE FORMULA I DONDE R[SUP,1} ES HIDROGENO, HIDROXI, ALCOXI C{SUB,1} OO(ALQUILO C{SUB,1} }), -OCOAR DONDE A ES FENILO O FENILO OPCIONALMENTE SUSTITUIDO, -OSO{SUB,2}(ALQUILO DE CADENA LINEAL C{SUB,4} C{SUB,6}), O OSO{SUB,3}H; R{SUP,2} ES R{SUP,1}, CL O F; CON LA CONDICION DE QUE AL MENOS UNO DE R{SUP,1} O R{SUP,2} SEA UP,3} ES 1 IDINILO, DIMETIL O, DIETILAMINO, DIISOPROPILAMINO, O 1 HEXAMETILENIMINO; Y N ES 2 O 3; O UNA SAL FARMACEUTICAMENTE ACEPTABLE O SOLVATO DE LA MISMA.THIS INVENTION PROVIDES FORMULA I COMPOUNDS WHERE R [SUP, 1} IS HYDROGEN, HYDROXY, ALCOXI C {SUB, 1} OO (RENT C {SUB, 1}}), -OCOAR WHERE IT IS PHENYLL OR PHENYL OPTIONALLY REPLACED, - BEAR {SUB, 2} (LINEAR CHAIN RENT C {SUB, 4} C {SUB, 6}), OR BEAR {SUB, 3} H; R {SUP, 2} ES R {SUP, 1}, CL O F; WITH THE CONDITION THAT AT LEAST ONE OF R {SUP, 1} OR R {SUP, 2} BE UP, 3} IS 1 IDINYL, DIMETHYL, DIETILAMINE, DIISOPROPILAMINE, OR 1 HEXAMETILENIMINE; AND N IS 2 OR 3; OR A PHARMACEUTICALLY ACCEPTABLE OR SOLVATE SALT OF THE SAME.

ES97303090T 1996-05-09 1997-05-06 BENZOTIOPHENES, COMPOSITIONS THAT CONTAIN THEM AND PROCEDURES. Expired - Lifetime ES2180893T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1711096P 1996-05-09 1996-05-09

Publications (1)

Publication Number Publication Date
ES2180893T3 true ES2180893T3 (en) 2003-02-16

Family

ID=21780779

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97303090T Expired - Lifetime ES2180893T3 (en) 1996-05-09 1997-05-06 BENZOTIOPHENES, COMPOSITIONS THAT CONTAIN THEM AND PROCEDURES.

Country Status (9)

Country Link
US (1) US5843984A (en)
EP (1) EP0806420B1 (en)
JP (1) JP2000511515A (en)
AR (1) AR007012A1 (en)
AU (1) AU2932197A (en)
CA (1) CA2253858A1 (en)
DE (1) DE69714504T2 (en)
ES (1) ES2180893T3 (en)
WO (1) WO1997041851A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653297B1 (en) * 1997-07-03 2003-11-25 Medical College Of Hampton Roads Control of selective estrogen receptor modulators
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
PT1175433E (en) 1999-05-04 2005-11-30 Strakan Int Ltd ANDROGEN GLYCOSITES AND ITS ANDROGENIC ACTIVITY
HU230543B1 (en) * 1999-07-06 2016-11-28 Endorecherche, Inc. Medicament useful for treating and/or suppressing weight gain
US6605605B2 (en) * 2000-11-13 2003-08-12 Milton Hammerly Estrogenic substances combined with cruciferous indole compounds
AU2002235348A1 (en) * 2001-01-17 2002-07-30 Praecis Pharmaceuticals Inc. Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators
WO2003011282A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
EP1601669B1 (en) 2003-03-07 2008-12-24 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
JP2006519869A (en) * 2003-03-07 2006-08-31 シェーリング　コーポレイション Substituted azetidinone compounds, processes for preparing substituted azetidinone compounds, their formulations and uses
ES2311806T3 (en) 2003-03-07 2009-02-16 Schering Corporation AZETIDINONA COMPOSITE SUBSTITUTED, FORNULATIONS AND USES OF THE SAME FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA.
US7655700B2 (en) 2005-08-25 2010-02-02 Michigan State University Transgenic mouse model and methods for treatment of neuro muscular disease by interfering with androgen-androgen receptor interaction in skeletal muscles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600714A (en) * 1984-04-26 1986-07-15 Smithkline Beckman Corporation Fenoldopam 4',8-bis-hydrogen sulfate and dopaminergic use thereof
CA2041280A1 (en) * 1990-05-10 1991-11-11 Yosuke Sawada Arylsulfatase
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists

Also Published As

Publication number Publication date
EP0806420B1 (en) 2002-08-07
DE69714504D1 (en) 2002-09-12
WO1997041851A1 (en) 1997-11-13
US5843984A (en) 1998-12-01
AU2932197A (en) 1997-11-26
EP0806420A1 (en) 1997-11-12
JP2000511515A (en) 2000-09-05
CA2253858A1 (en) 1997-11-13
AR007012A1 (en) 1999-10-13
DE69714504T2 (en) 2003-04-03

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