ES2180417B1 - NEW OVEREXPRESSED PROTEIN IN CANCER DE PROSTATA. - Google Patents
NEW OVEREXPRESSED PROTEIN IN CANCER DE PROSTATA.Info
- Publication number
- ES2180417B1 ES2180417B1 ES200100592A ES200100592A ES2180417B1 ES 2180417 B1 ES2180417 B1 ES 2180417B1 ES 200100592 A ES200100592 A ES 200100592A ES 200100592 A ES200100592 A ES 200100592A ES 2180417 B1 ES2180417 B1 ES 2180417B1
- Authority
- ES
- Spain
- Prior art keywords
- protein
- overexpressed
- new
- cancer
- prostate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
Abstract
Nueva proteína sobreexpresada en cáncer de próstata. Un nuevo gen y proteína sobreexpresado en cáncer de próstata ha sido identificado y secuenciado. En la presente invención se demuestra que se sobreexpresa en adenocarcinoma de próstata mediante la técnica RT-PCR y western-blot. La expresión de esta proteína está correlacionada con la proliferación de tumores. Han sido generados anticuerpos específicos que detectan específicamente la proteína tanto en líneas celulares como en tejidos humanos normales y tumorales usando métodos inmunológicos. Empleando estos anticuerpos, demostramos que la proteína se sobreexpresa en la mayoría de los adenocarcinomas de próstata humanos, por lo que la detección de este transcrito y proteína constituye un nuevo marcador de este tipo de tumores, con potencial utilidad en su diagnóstico. Esta proteína es además una proteína diana la identificación de compuestos para terapias antitumorales.New protein overexpressed in prostate cancer. A new gene and protein overexpressed in prostate cancer has been identified and sequenced. The present invention demonstrates that it is overexpressed in prostate adenocarcinoma using the RT-PCR and western-blot technique. The expression of this protein is correlated with the proliferation of tumors. Specific antibodies have been generated that specifically detect the protein both in cell lines and in normal and tumor human tissues using immunological methods. Using these antibodies, we demonstrate that the protein is overexpressed in most human prostate adenocarcinomas, so the detection of this transcript and protein constitutes a new marker of this type of tumors, with potential utility in its diagnosis. This protein is also a target protein identifying compounds for antitumor therapies.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100592A ES2180417B1 (en) | 2001-03-14 | 2001-03-14 | NEW OVEREXPRESSED PROTEIN IN CANCER DE PROSTATA. |
PCT/ES2002/000122 WO2002072633A1 (en) | 2001-03-14 | 2002-03-14 | Novel overexpressed protein in prostate cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100592A ES2180417B1 (en) | 2001-03-14 | 2001-03-14 | NEW OVEREXPRESSED PROTEIN IN CANCER DE PROSTATA. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2180417A1 ES2180417A1 (en) | 2003-02-01 |
ES2180417B1 true ES2180417B1 (en) | 2004-05-16 |
Family
ID=8497077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100592A Expired - Fee Related ES2180417B1 (en) | 2001-03-14 | 2001-03-14 | NEW OVEREXPRESSED PROTEIN IN CANCER DE PROSTATA. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2180417B1 (en) |
WO (1) | WO2002072633A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004067560A2 (en) * | 2003-01-27 | 2004-08-12 | Gsf - Forschungszentrum Für Umwelt Und Gesundheit, Gmbh | Herpes simplex vp16 protein binding polypeptides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003506020A (en) * | 1999-07-21 | 2003-02-18 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 25 human prostate proteins and prostate cancer-related proteins |
GB9917725D0 (en) * | 1999-07-28 | 1999-09-29 | Medical Res Council | Peptides |
-
2001
- 2001-03-14 ES ES200100592A patent/ES2180417B1/en not_active Expired - Fee Related
-
2002
- 2002-03-14 WO PCT/ES2002/000122 patent/WO2002072633A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2002072633A1 (en) | 2002-09-19 |
ES2180417A1 (en) | 2003-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20030201 Kind code of ref document: A1 |
|
FG2A | Definitive protection |
Ref document number: 2180417B1 Country of ref document: ES |
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FD2A | Announcement of lapse in spain |
Effective date: 20180807 |